diff --git a/server/data_files/GDC/model-3.3.0/_definitions.yaml b/server/data_files/GDC/model-3.3.0/_definitions.yaml new file mode 100644 index 0000000..d4a9574 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/_definitions.yaml @@ -0,0 +1,256 @@ +id: _definitions + +uuid: + $ref: "_terms.yaml#/uuid" + type: string + pattern: "^[a-fA-F0-9]{8}-[a-fA-F0-9]{4}-[a-fA-F0-9]{4}-[a-fA-F0-9]{4}-[a-fA-F0-9]{12}$" + systemAlias: node_id + +parent_uuids: + type: array + minItems: 1 + items: + $ref: "#/uuid" + uniqueItems: true + +foreign_key_project: + type: object + # Allow true here because we can have other unique keys defined on + # a target type + additionalProperties: True + # Can either use 'id' which are GDC IDs (uuid) or 'submitter_id' + # which are user defined IDs ("submitter IDs in the backend") + properties: + id: + $ref: "#/uuid" + submitter_id: + type: string + +to_one_project: + anyOf: + - type: array + items: + $ref: "#/foreign_key_project" + minItems: 1 + maxItems: 1 + - $ref: "#/foreign_key_project" + +to_many_project: + anyOf: + - type: array + items: + $ref: "#/foreign_key_project" + minItems: 1 + - $ref: "#/foreign_key_project" + +foreign_key: + type: object + # Allow true here because we can have other unique keys defined on + # a target type + additionalProperties: True + # Can either use 'id' which are GDC IDs (uuid) or 'submitter_id' + # which are user defined IDs ("submitter IDs in the backend") + properties: + id: + $ref: "#/uuid" + submitter_id: + type: string + +to_one: + anyOf: + - type: array + items: + $ref: "#/foreign_key" + minItems: 1 + maxItems: 1 + - $ref: "#/foreign_key" + +to_many: + anyOf: + - type: array + items: + $ref: "#/foreign_key" + minItems: 1 + - $ref: "#/foreign_key" + +datetime: + $ref: "_terms.yaml#/datetime" + oneOf: + - type: string + format: date-time + - type: 'null' + +file_name: + $ref: "_terms.yaml#/file_name/common" + type: string + +file_size: + $ref: "_terms.yaml#/file_size/common" + type: integer + +file_format: + $ref: "_terms.yaml#/file_format" + type: string + +md5sum: + $ref: "_terms.yaml#/md5sum/common" + type: string + pattern: "^[a-f0-9]{32}$" + +release_state: + description: >- + Release state of an entity. + default: unreleased + enum: + - unreleased + - released + - redacted + +data_bundle_state: + description: >- + State of a data bundle. + default: submitted + enum: + - submitted + - validated + - error + - released + - suppressed + - redacted + +data_file_error_type: + $ref: "_terms.yaml#/data_file_error_type" + enum: + - file_size + - file_format + - md5sum + +state: + $ref: "_terms.yaml#/state" + default: validated + downloadable: + - uploaded + - md5summed + - validating + - validated + - error + - invalid + - released + public: + - live + oneOf: + - enum: #This list covers legacy data + - uploading + - uploaded + - md5summing + - md5summed + - validating + - error + - invalid + - suppressed + - redacted + - live + - enum: #This list covers all future data 1/15/16 + - validated + - submitted + - released + +file_state: + $ref: "_terms.yaml#/file_state" + default: registered + enum: + - registered + - uploading + - uploaded + - validating + - validated + - submitted + - processing + - processed + - released + - error + - deleted + +qc_metrics_state: + $ref: "_terms.yaml#/qc_metric_state" + enum: + - FAIL + - PASS + - WARN + - Unknown + - Not Reported + +project_id: + $ref: "_terms.yaml#/project_id" + type: string + +data_file_properties: + $ref: "#/ubiquitous_properties" + + file_name: + $ref: "#/file_name" + + file_size: + $ref: "#/file_size" + + md5sum: + $ref: "#/md5sum" + + file_state: + $ref: "#/file_state" + + error_type: + $ref: "#/data_file_error_type" + + state_comment: + description: >- + Optional comment about why the file is in the current state, mainly for invalid state. + type: string + +workflow_properties: + $ref: "#/ubiquitous_properties" + + workflow_link: + $ref: "_terms.yaml#/workflow_link/common" + type: string + + workflow_version: + $ref: "_terms.yaml#/workflow_version/common" + type: string + + workflow_start_datetime: + $ref: "#/datetime" + + workflow_end_datetime: + $ref: "#/datetime" + +ubiquitous_properties: + type: + type: string + + id: + $ref: "#/uuid" + + submitter_id: + description: >- + A project-specific identifier for a node. This property is the calling card/nickname/alias + for a unit of submission. It can be used in place of the uuid for identifying + or recalling a node. + type: string + + batch_id: + description: >- + GDC submission batch indicator. It is unique within the context of a project. + type: integer + + state: + $ref: "#/state" + + project_id: + $ref: "#/project_id" + + created_datetime: + $ref: "#/datetime" + + updated_datetime: + $ref: "#/datetime" diff --git a/server/data_files/GDC/model-3.3.0/_terms.yaml b/server/data_files/GDC/model-3.3.0/_terms.yaml new file mode 100644 index 0000000..0a42187 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/_terms.yaml @@ -0,0 +1,7809 @@ + +id: _terms + +a260_a280_ratio: + common: + description: >- + Numeric value that represents the sample ratio of nucleic acid absorbance at + 260 nm and 280 nm, used to determine a measure of DNA purity. + termDef: + term: >- + Nucleic Acid Absorbance at 260 And Absorbance at 280 DNA Purity Ratio Value + source: caDSR + cde_id: 5432595 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432595%20and%20ver_nr=1.0" + +aa_change: + common: + description: >- + Alphanumeric value used to describe the amino acid change for a specific genetic + variant. Example: R116Q. + termDef: + term: >- + Molecular Laboratory Procedure Amino Acid Change Text + source: caDSR + cde_id: 6142508 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142508%20and%20ver_nr=1.0" + +adapter_name: + common: + description: >- + Name of the sequencing adapter. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +adapter_sequence: + common: + description: >- + Base sequence of the sequencing adapter. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +additional_pathology_findings: + common: + description: >- + A section header that includes additional pathologic findings. + termDef: + term: >- + Additional Pathologic Findings + source: NCIt + cde_id: C158809 + cde_version: 20.10d + term_url: + term_id: C158809 + term_version: 20.10d + +adrenal_hormone: + common: + description: >- + Indicates the presence of the adrenal hormone. The adrenal hormone is made from + cholesterol and protein produced by the adrenal glands and regulate electrolyte + balance, blood pressure, inflammation, blood sugar balance, and immune system + control. + termDef: + term: >- + Adrenal Hormone + source: NCIt + cde_id: C2264 + cde_version: 21.04d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2264" + +adverse_event: + common: + description: >- + Text that represents the Common Terminology Criteria for Adverse Events low + level term name for an adverse event. + termDef: + term: >- + Common Terminology Criteria for Adverse Events Version 4.0 Low Level Term + Name + source: caDSR + cde_id: 3125302 + cde_version: 1.1 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3125302%20and%20ver_nr=1.1" + +adverse_event_grade: + common: + description: >- + Numeric representation of the intensity/severity of an unfavorable and unintended + sign (including an abnormal laboratory finding), symptom, syndrome, or disease, + temporally associated with the use of a medical product or procedure, regardless + of whether or not it is considered related to the product or procedure (attribution + of unrelated, unlikely, possible, probable, or definite). + termDef: + term: >- + Adverse Event Severity Grade + source: caDSR + cde_id: 2944515 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2944515%20and%20ver_nr=1.0" + +age_at_diagnosis: + common: + description: >- + Age at the time of diagnosis expressed in number of days since birth. + termDef: + term: >- + Patient Diagnosis Age Day Value + source: caDSR + cde_id: 3225640 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3225640%20and%20ver_nr=2.0" + +age_at_index: + common: + description: >- + The patient's age (in years) on the reference or anchor date used during date + obfuscation. + termDef: + term: >- + Patient Age at Index + source: caDSR + cde_id: 6028530 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6028530%20and%20ver_nr=1.0" + +age_at_last_exposure: + common: + description: >- + The study participant's age at the time they were last exposed. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +age_at_onset: + common: + description: >- + Numeric value used to represent the age of the patient when exposure to a specific + environmental factor began. + termDef: + term: >- + Patient Environmental Exposure Onset Age Day Value + source: + cde_id: + cde_version: + term_url: + +age_is_obfuscated: + common: + description: >- + The age or other properties related to the patient's age have been modified + for compliance reasons. The actual age may differ from what was reported in + order to comply with the Health Insurance Portability and Accountability Act + (HIPAA). + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +aids_risk_factors: + common: + description: >- + The text term used to describe a risk factor of the acquired immunodeficiency + syndrome (AIDS) that the patient either had at the time of the study or experienced + in the past. + termDef: + term: >- + AIDS Risk Factor Text Name + source: + cde_id: + cde_version: + term_url: + +ajcc_clinical_m: + common: + description: >- + Extent of the distant metastasis for the cancer based on evidence obtained from + clinical assessment parameters determined prior to treatment. + termDef: + term: >- + Neoplasm American Joint Committee on Cancer Clinical Distant Metastasis M + Stage + source: caDSR + cde_id: 3440331 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440331%20and%20ver_nr=1.0" + +ajcc_clinical_n: + common: + description: >- + Extent of the regional lymph node involvement for the cancer based on evidence + obtained from clinical assessment parameters determined prior to treatment. + termDef: + term: >- + Neoplasm American Joint Committee on Cancer Clinical Regional Lymph Node N + Stage + source: caDSR + cde_id: 3440330 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440330%20and%20ver_nr=1.0" + +ajcc_clinical_stage: + common: + description: >- + Stage group determined from clinical information on the tumor (T), regional + node (N) and metastases (M) and by grouping cases with similar prognosis for + cancer. + termDef: + term: >- + Neoplasm American Joint Committee on Cancer Clinical Group Stage + source: caDSR + cde_id: 3440332 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440332%20and%20ver_nr=1.0" + +ajcc_clinical_t: + common: + description: >- + Extent of the primary cancer based on evidence obtained from clinical assessment + parameters determined prior to treatment. + termDef: + term: >- + Neoplasm American Joint Committee on Cancer Clinical Primary Tumor T Stage + source: caDSR + cde_id: 3440328 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440328%20and%20ver_nr=1.0" + +ajcc_pathologic_m: + common: + description: >- + Code to represent the defined absence or presence of distant spread or metastases + (M) to locations via vascular channels or lymphatics beyond the regional lymph + nodes, using criteria established by the American Joint Committee on Cancer + (AJCC). + termDef: + term: >- + American Joint Committee on Cancer Metastasis Stage Code + source: caDSR + cde_id: 3045439 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3045439%20and%20ver_nr=1.0" + +ajcc_pathologic_n: + common: + description: >- + The codes that represent the stage of cancer based on the nodes present (N stage) + according to criteria based on multiple editions of the AJCC's Cancer Staging + Manual. + termDef: + term: >- + Neoplasm Disease Lymph Node Stage American Joint Committee on Cancer Code + source: caDSR + cde_id: 3203106 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3203106%20and%20ver_nr=1.0" + +ajcc_pathologic_stage: + common: + description: >- + The extent of a cancer, especially whether the disease has spread from the original + site to other parts of the body based on AJCC staging criteria. + termDef: + term: >- + Neoplasm Disease Stage American Joint Committee on Cancer Code + source: caDSR + cde_id: 3203222 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3203222%20and%20ver_nr=1.0" + +ajcc_pathologic_t: + common: + description: >- + Code of pathological T (primary tumor) to define the size or contiguous extension + of the primary tumor (T), using staging criteria from the American Joint Committee + on Cancer (AJCC). + termDef: + term: >- + American Joint Committee on Cancer Tumor Stage Code + source: caDSR + cde_id: 3045435 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3045435%20and%20ver_nr=1.0" + +ajcc_staging_system_edition: + common: + description: >- + The text term used to describe the version or edition of the American Joint + Committee on Cancer Staging Handbooks, a publication by the group formed for + the purpose of developing a system of staging for cancer that is acceptable + to the American medical profession and is compatible with other accepted classifications. + termDef: + term: >- + American Joint Committee on Cancer Publication Version Type + source: caDSR + cde_id: 2722309 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2722309%20and%20ver_nr=1.0" + +alcohol_days_per_week: + common: + description: >- + Numeric value used to describe the average number of days each week that a person + consumes an alcoholic beverage. + termDef: + term: >- + Alcohol Consumption Weekly Days Usage Number + source: caDSR + cde_id: 3114013 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3114013%20and%20ver_nr=1.0" + +alcohol_drinks_per_day: + common: + description: >- + Numeric value used to describe the average number of alcoholic beverages a person + consumes per day. + termDef: + term: >- + Person Daily Alcohol Consumption Count + source: caDSR + cde_id: 3124961 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3124961%20and%20ver_nr=1.0" + +alcohol_frequency: + common: + description: >- + Describes how often the subject drinks alcohol. + termDef: + term: >- + Alcohol Frequency + source: + cde_id: + cde_version: + term_url: + +alcohol_history: + common: + description: >- + A response to a question that asks whether the participant has consumed at least + 12 drinks of any kind of alcoholic beverage in their lifetime. + termDef: + term: >- + Alcohol Lifetime History Indicator + source: caDSR + cde_id: 2201918 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2201918%20and%20ver_nr=1.0" + +alcohol_intensity: + common: + description: >- + Category to describe the patient's current level of alcohol use as self-reported + by the patient. + termDef: + term: >- + Person Self-Report Alcoholic Beverage Exposure Category + source: caDSR + cde_id: 3457767 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3457767%20and%20ver_nr=1.0" + +alcohol_type: + common: + description: >- + A specific type of alcohol. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +aliquot_quantity: + common: + description: >- + The quantity in micrograms (ug) of the aliquot(s) derived from the analyte(s) + shipped for sequencing and characterization. + termDef: + term: >- + Biospecimen Aliquot Quantity + source: + cde_id: + cde_version: + term_url: + +aliquot_volume: + common: + description: >- + The volume in microliters (ul) of the aliquot(s) derived from the analyte(s) + shipped for sequencing and characterization. + termDef: + term: >- + Biospecimen Aliquot Volume + source: + cde_id: + cde_version: + term_url: + +amount: + common: + description: >- + Weight in grams or volume in mL. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +analyte_quantity: + common: + description: >- + The quantity in micrograms (ug) of the analyte(s) derived from the analyte(s) + shipped for sequencing and characterization. + termDef: + term: >- + Biospecimen Analyte Quantity + source: + cde_id: + cde_version: + term_url: + +analyte_type: + common: + description: >- + Text term that represents the kind of molecular specimen analyte. + termDef: + term: >- + Molecular Specimen Type Text Name + source: caDSR + cde_id: 2513915 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2513915%20and%20ver_nr=2.0" + +analyte_type_id: + common: + description: >- + A single letter code used to identify a type of molecular analyte. + termDef: + term: >- + Molecular Analyte Identification Code + source: caDSR + cde_id: 5432508 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432508%20and%20ver_nr=1.0" + +analyte_volume: + common: + description: >- + The volume in microliters (ul) of the aliquot(s) derived from the analyte(s) + shipped for sequencing and characterization. + termDef: + term: >- + Biospecimen Analyte Volume + source: + cde_id: + cde_version: + term_url: + +anaplasia_present: + common: + description: >- + Yes/no/unknown/not reported indicator used to describe whether anaplasia was + present at the time of diagnosis. + termDef: + term: >- + Anaplastic Lesion Present Indicator + source: caDSR + cde_id: 6059599 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6059599%20and%20ver_nr=1.0" + +anaplasia_present_type: + common: + description: >- + The text term used to describe the morphologic findings indicating the presence + of a malignant cellular infiltrate characterized by the presence of large pleomorphic + cells, necrosis, and high mitotic activity in a tissue sample. + termDef: + term: >- + Anaplastic Lesion Classification Category + source: caDSR + cde_id: 4925534 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4925534%20and%20ver_nr=1.0" + +aneuploidy: + common: + description: >- + A chromosomal abnormality in which there is an addition or loss of chromosomes + within a set (e.g., 23 + 22 or 23 + 24). + termDef: + term: >- + Aneuploidy + source: NCIt + cde_id: C2873 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2873" + +ann_arbor_b_symptoms: + common: + description: >- + Text term to signify whether lymphoma B-symptoms are present as noted in the + patient's medical record. + termDef: + term: >- + Lymphoma B-Symptoms Medical Record Documented Indicator + source: caDSR + cde_id: 2902402 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2902402%20and%20ver_nr=1.0" + +ann_arbor_b_symptoms_described: + common: + description: >- + Text describing the specific lymphoma B-symptoms present. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +ann_arbor_clinical_stage: + common: + description: >- + The text term used to describe the clinical classification of lymphoma, as defined + by the Ann Arbor Lymphoma Staging System. + termDef: + term: >- + Ann Arbor Clinical Stage + source: caDSR + cde_id: 5615604 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5615604%20and%20ver_nr=1.0" + +ann_arbor_extranodal_involvement: + common: + description: >- + Indicator that identifies whether a patient with malignant lymphoma has lymphomatous + involvement of an extranodal site. + termDef: + term: >- + Lymphomatous Extranodal Site Involvement Indicator + source: caDSR + cde_id: 3364582 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3364582%20and%20ver_nr=1.0" + +ann_arbor_pathologic_stage: + common: + description: >- + The text term used to describe the pathologic classification of lymphoma, as + defined by the Ann Arbor Lymphoma Staging System. + termDef: + term: >- + Ann Arbor Pathologic Stage + source: caDSR + cde_id: 5615605 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5615605%20and%20ver_nr=1.0" + +antigen: + common: + description: >- + The text term used to describe an antigen included in molecular testing. + termDef: + term: >- + Molecular Laboratory Procedure Antigen Name + source: caDSR + cde_id: 6142523 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142523%20and%20ver_nr=1.0" + +asbestos_exposure: + common: + description: >- + The yes/no/unknown indicator used to describe whether the patient was exposed + to asbestos. + termDef: + term: >- + Asbestos Exposure Ind-3 + source: caDSR + cde_id: 1253 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=1253%20and%20ver_nr=3.0" + +asbestos_exposure_type: + common: + description: >- + The type of asbestos exposure the study participant experienced. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +average_base_quality: + common: + description: >- + Average base quality collected from samtools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +average_insert_size: + common: + description: >- + Average insert size collected from samtools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +average_read_length: + common: + description: >- + Average read length collected from samtools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +barretts_esophagus_goblet_cells_present: + common: + description: >- + The yes/no/unknown indicator used to describe whether goblet cells were determined + to be present in a patient diagnosed with Barrett's esophagus. + termDef: + term: >- + Barrett's Esophagus Diagnosis Goblet Cell Present Indicator + source: caDSR + cde_id: 3440216 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440216%20and%20ver_nr=1.0" + +base_caller_name: + common: + description: >- + Name of the base caller. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +base_caller_version: + common: + description: >- + Version of the base caller. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +best_overall_response: + common: + description: >- + The best improvement achieved throughout the entire course of protocol treatment. + termDef: + term: >- + Best Response Assessment Type + source: caDSR + cde_id: 2003324 + cde_version: 4.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2003324%20and%20ver_nr=4.0" + +biospecimen_anatomic_site: + common: + description: >- + Text term that represents the name of the organ or tissue site of the submitted + sample. + termDef: + term: >- + Submitted Tumor Sample Primary Anatomic Site + source: caDSR + cde_id: 4742851 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4742851%20and%20ver_nr=1.0" + +biospecimen_laterality: + common: + description: >- + For tumors in paired organs, designates the side on which the specimen was obtained. + termDef: + term: >- + Specimen Laterality + source: caDSR + cde_id: 2007875 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2007875%20and%20ver_nr=1.0" + +biospecimen_type: + common: + description: >- + The text term used to describe the biological material used for testing, diagnostic, + treatment or research purposes. + termDef: + term: >- + Biospecimen Type + source: caBIG + cde_id: + cde_version: + term_url: + +biospecimen_volume: + common: + description: >- + The volume of the biospecimen. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +blood_test_normal_range_lower: + common: + description: >- + Numeric value used to describe the lower limit of the normal range used to describe + a healthy individual at the institution where the test was completed. + termDef: + term: >- + Laboratory Procedure Lower Limit of Normal Value + source: caDSR + cde_id: 6142571 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142571%20and%20ver_nr=1.0" + +blood_test_normal_range_upper: + common: + description: >- + Numeric value used to describe the upper limit of the normal range used to describe + a healthy individual at the institution where the test was completed. + termDef: + term: >- + Laboratory Procedure Upper Limit of Normal Value + source: caDSR + cde_id: 6142535 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142535%20and%20ver_nr=1.0" + +bmi: + common: + description: >- + A calculated numerical quantity that represents an individual's weight to height + ratio. + termDef: + term: >- + Body Mass Index Value + source: caDSR + cde_id: 2006410 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2006410%20and%20ver_nr=3.0" + +body_surface_area: + common: + description: >- + Numeric value used to represent the two-dimensional extent of the body surface + relating height to weight. + termDef: + term: >- + Person Body Surface Area Value + source: caDSR + cde_id: 653 + cde_version: 6.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=653%20and%20ver_nr=6.0" + +bone_marrow_malignant_cells: + common: + description: >- + The text term used to indicate whether there are malignant cells in the bone + marrow. + termDef: + term: >- + Malignant Bone Marrow Indicator + source: + cde_id: + cde_version: + term_url: + +breslow_thickness: + common: + description: >- + The number that describes the distance, in millimeters, between the upper layer + of the epidermis and the deepest point of tumor penetration. + termDef: + term: >- + Breslow Depth Measurement + source: caDSR + cde_id: 64809 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=64809%20and%20ver_nr=3.0" + +burkitt_lymphoma_clinical_variant: + common: + description: >- + Burkitt's lymphoma categorization based on clinical features that differ from + other forms of the same disease. + termDef: + term: >- + Burkitt Lymphoma Clinical Variant Type + source: caDSR + cde_id: 3770421 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3770421%20and%20ver_nr=1.0" + +cancer_detection_method: + common: + description: >- + The method used to detect disease. + termDef: + term: >- + Cancer Detection Type + source: + cde_id: + cde_version: + term_url: + +catalog_reference: + common: + description: >- + HCMI catalog reference number for cancer model. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +cause_of_death: + common: + description: >- + Text term to identify the cause of death for a patient. + termDef: + term: >- + Patient Death Reason + source: caDSR + cde_id: 2554674 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2554674%20and%20ver_nr=3.0" + +cause_of_death_source: + common: + description: >- + The text term used to describe the source used to determine the patient's cause + of death. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +cause_of_response: + common: + description: >- + The text term used to describe the suspected cause or reason for the patient + disease response. + termDef: + term: >- + Disease Response Reason Text + source: caDSR + cde_id: 6161025 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161025%20and%20ver_nr=1.0" + +cd4_count: + common: + description: >- + The text term used to describe the outcome of the procedure to determine the + amount of the CD4 expressing cells in a sample. + termDef: + term: >- + Laboratory Procedure CD4 Expressing Cell Count Outcome + source: caDSR + cde_id: 4182751 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4182751%20and%20ver_nr=1.0" + +cdc_hiv_risk_factors: + common: + description: >- + The text term used to describe a risk factor for human immunodeficiency virus, + as described by the Centers for Disease Control. + termDef: + term: >- + CDC HIV Risk Factor Text Term + source: + cde_id: + cde_version: + term_url: + +cell_count: + common: + description: >- + Numeric value used to describe the number of cells used for molecular testing. + termDef: + term: >- + Molecular Laboratory Procedure Cell Count + source: caDSR + cde_id: 6142528 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142528%20and%20ver_nr=1.0" + +channel: + common: + description: >- + The corresponding color channel used to generate this data file. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +chemical_exposure_type: + common: + description: >- + The specific type of contact with a chemical substance through touch, inhalation, + or ingestion. + termDef: + term: >- + Chemical Exposure + source: NCIt + cde_id: C36290 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36290" + +chemo_concurrent_to_radiation: + common: + description: >- + The text term used to describe whether the patient was receiving chemotherapy + concurrent to radiation. + termDef: + term: >- + Chemotherapy Given Concurrent to Radiation + source: + cde_id: + cde_version: + term_url: + +child_pugh_classification: + common: + description: >- + The text term used to describe the classification used in the prognosis of chronic + liver disease, mainly cirrhosis. + termDef: + term: >- + Child-Pugh Classification Grade + source: caDSR + cde_id: 2931791 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2931791%20and%20ver_nr=1.0" + +chip_id: + common: + description: >- + User specified identifier for the chip used to perform the methylation microarray. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +chip_position: + common: + description: >- + User specified identifier for the specific position on the chip that the sample + was loaded into to perform the methylation microarray. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +chipseq_antibody: + common: + description: >- + The antibody used in the ChIP-Seq assay. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +chipseq_target: + common: + description: >- + Antibody target of the ChIP-Seq assay + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +chromosomal_translocation: + common: + description: >- + A genetic exchange where a piece of one chromosome is transferred to another + chromosome. + termDef: + term: >- + Chromosomal Translocation + source: NCIt + cde_id: C3420 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3420" + +chromosome: + common: + description: >- + The text term used to describe a chromosome targeted or included in molecular + testing. If a specific genetic variant is being reported, this property can + be used to capture the chromosome where that variant is located. + termDef: + term: >- + Molecular Laboratory Procedure Chromosome Name + source: caDSR + cde_id: 6142404 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142404%20and%20ver_nr=1.0" + +chromosome_arm: + common: + description: >- + Under the microscope chromosomes appear as thin, thread-like structures. They + all have a short arm and long arm separated by a primary constriction called + the centromere. The short arm is designated as p and the long arm as q. + termDef: + term: >- + Chromosome Arm + source: NCIt + cde_id: C13355 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13355" + +cigarettes_per_day: + common: + description: >- + The average number of cigarettes smoked per day. + termDef: + term: >- + Smoking Use Average Number + source: caDSR + cde_id: 2001716 + cde_version: 4.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2001716%20and%20ver_nr=4.0" + +circumferential_resection_margin: + common: + description: >- + Numeric value used to describe the non-peritonealised bare area of rectum, comprising + anterior and posterior segments, when submitted as a surgical specimen resulting + from excision of cancer of the rectum. + termDef: + term: >- + Circumferential Resection Margin Measurement + source: caDSR + cde_id: 6161030 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161030%20and%20ver_nr=1.0" + +classification_of_tumor: + common: + description: >- + Text that describes the kind of disease present in the tumor specimen as related + to a specific timepoint. + termDef: + term: >- + Tumor Tissue Disease Description Type + source: caDSR + cde_id: 3288124 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3288124%20and%20ver_nr=1.0" + +clinical_trial_indicator: + common: + description: >- + Indicator used to describe whether the treatment was part of a clinical trial. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +clonality: + common: + description: >- + The text term used to describe whether a genomic variant is related by descent + from a single progenitor cell. + termDef: + term: >- + Clonality + source: NCIt + cde_id: C18304 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18304" + term_id: C18304 + term_version: 19.12e + +coal_dust_exposure: + common: + description: >- + The yes/no/unknown indicator used to describe whether a patient was exposed + to fine powder derived by the crushing of coal. + termDef: + term: >- + Person Coal Dust Exposure Indicator + source: caDSR + cde_id: + cde_version: + term_url: + +cog_liver_stage: + common: + description: >- + The text term used to describe the staging classification of liver tumors, as + defined by the Children's Oncology Group (COG). This staging system specifically + describes the extent of the primary tumor prior to treatment. + termDef: + term: >- + PRETEXT Staging System Primary Childhood Malignant Liver Tumor Stage + source: caDSR + cde_id: 6013618 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6013618%20and%20ver_nr=1.0" + +cog_neuroblastoma_risk_group: + common: + description: >- + Text term that represents the categorization of patients on the basis of prognostic + factors per a system developed by Children's Oncology Group (COG). Risk level + is used to assign treatment intensity. + termDef: + term: >- + Children's Oncology Group Neuroblastoma Risk Group Assignment Category + source: caDSR + cde_id: 4616452 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4616452%20and%20ver_nr=1.0" + +cog_renal_stage: + common: + description: >- + The text term used to describe the staging classification of renal tumors, as + defined by the Children's Oncology Group (COG). + termDef: + term: >- + SIOP/COG/NWTSG Staging System Wilms Tumor Stage + source: caDSR + cde_id: 6013641 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6013641%20and%20ver_nr=1.0" + +cog_rhabdomyosarcoma_risk_group: + common: + description: >- + Text term used to describe the classification of rhabdomyosarcoma, as defined + by the Children's Oncology Group (COG). + termDef: + term: >- + Rhabdomyosarcoma Children's Oncology Group Risk Assessment Category + source: caDSR + cde_id: 6133604 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6133604%20and%20ver_nr=1.0" + +columnar_mucosa_present: + common: + description: >- + Indicator noting whether columnar mucosa was present within the tissue. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +comorbidities: + common: + description: >- + The text term used to describe a patient with one or more diseases or conditions, + which coexist with the patient's malignant disease at the same time. + termDef: + term: >- + Index Date To Comorbidity Day Count + source: caDSR + cde_id: 2970715 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2970715%20and%20ver_nr=1.0" + +comorbidity: + common: + description: >- + The text term used to describe a comorbidity disease, which coexists with the + patient's malignant disease. + termDef: + term: >- + Index Date To Comorbidity Day Count + source: caDSR + cde_id: 2970715 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2970715%20and%20ver_nr=1.0" + +comorbidity_method_of_diagnosis: + common: + description: >- + The text term used to describe the method used to diagnose the patient's comorbid + disease. + termDef: + term: >- + Comorbidity Disease Diagnosis Method Type + source: caDSR + cde_id: 6142386 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142386%20and%20ver_nr=1.0" + +composition: + common: + description: >- + Text term that represents the cellular composition of the sample. + termDef: + term: >- + Biospecimen Cellular Composition Type + source: caDSR + cde_id: 5432591 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432591%20and%20ver_nr=1.0" + +concentration: + common: + description: >- + Numeric value that represents the concentration of an analyte or aliquot extracted + from the sample or sample portion, measured in milligrams per milliliter. + termDef: + term: >- + Biospecimen Analyte or Aliquot Extracted Concentration Milligram per Milliliter + Value + source: caDSR + cde_id: 5432594 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432594%20and%20ver_nr=1.0" + +consent_type: + common: + description: >- + The text term used to describe the type of consent obtain from the subject for + participation in the study. + termDef: + term: >- + Subject Consent Type + source: + cde_id: + cde_version: + term_url: + +consistent_pathology_review: + common: + description: >- + Indicates whether a recent review of tissue is consistent with a prior pathology + review. + termDef: + term: >- + Consistent Pathology Review + source: + cde_id: + cde_version: + term_url: + +contamination: + common: + description: >- + Fraction of reads coming from cross-sample contamination collected from GATK4. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +contamination_error: + common: + description: >- + Estimation error of cross-sample contamination collected from GATK4. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +copy_number: + common: + description: >- + Numeric value used to describe the number of times a section of the genome is + repeated or copied within an insertion, duplication or deletion variant. + termDef: + term: >- + Molecular Laboratory Procedure Copy Number Count + source: caDSR + cde_id: 6142519 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142519%20and%20ver_nr=1.0" + +country_of_residence_at_enrollment: + common: + description: >- + The text term used to describe the patient's country of residence at the time + they were enrolled in the study. + termDef: + term: >- + Country of Residence + source: caDSR + cde_id: 7050286 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=7050286%20and%20ver_nr=1.0" + +course_number: + common: + description: >- + The number assigned to a course of therapeutic agent administration, indicating + where a particular course of treatment falls within a sequence of treatments. + termDef: + term: + source: NCIt + cde_id: C166235 + cde_version: 22.05e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166235" + +creation_datetime: + common: + description: >- + The datetime of portion creation encoded as seconds from epoch. + termDef: + term: >- + Biospecimen Portion Creation Seconds Date/Time + source: caDSR + cde_id: 5432592 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432592%20and%20ver_nr=1.0" + +current_weight: + common: + description: >- + Numeric value that represents the current weight of the sample, measured in + milligrams. + termDef: + term: >- + Tissue Sample Current Weight Milligram Value + source: caDSR + cde_id: 5432606 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432606%20and%20ver_nr=1.0" + +cytoband: + common: + description: >- + Alphanumeric value used to describe the cytoband or chromosomal location targeted + or included in molecular analysis. If a specific genetic variant is being reported, + this property can be used to capture the cytoband where the variant is located. + Format: [chromosome][chromosome arm].[band+sub-bands]. Example: 17p13.1. + termDef: + term: >- + Molecular Laboratory Procedure Cytoband Text + source: caDSR + cde_id: 6142405 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142405%20and%20ver_nr=1.0" + +data_category: + common: + description: >- + Broad categorization of the contents of the data file. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +data_file_error_type: + common: + description: >- + Type of error for the data file object. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +data_format: + common: + description: >- + Format of the data files. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +data_type: + common: + description: >- + Specific content type of the data file. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +datetime: + common: + description: >- + A combination of date and time of day in the form [-]CCYY-MM-DDThh:mm:ss[Z|(+|-)hh:mm] + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +days_to_adverse_event: + common: + description: >- + Number of days between the date used for index and the date of the patient's + adverse event. + termDef: + term: >- + Index Date To Adverse Event Day Count + source: caDSR + cde_id: 6154728 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154728%20and%20ver_nr=1.0" + +days_to_best_overall_response: + common: + description: >- + Number of days between the date used for index and the date of the patient was + thought to have the best overall response to their disease. + termDef: + term: >- + Index Date To Overall Best Response Day Count + source: caDSR + cde_id: 6154732 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154732%20and%20ver_nr=1.0" + +days_to_birth: + common: + description: >- + Number of days between the date used for index and the date from a person's + date of birth represented as a calculated negative number of days. + termDef: + term: >- + Index Date To Birth Day Count + source: caDSR + cde_id: 6154723 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154723%20and%20ver_nr=1.0" + +days_to_collection: + common: + description: >- + The number of days from the index date to the date a sample was received by + the Biospecimen Core Resource (BCR) or other center for processing. + termDef: + term: >- + Biospecimen Collection Date Less Initial Pathologic Diagnosis Date Calculated + Day Value + source: caDSR + cde_id: 3008340 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3008340%20and%20ver_nr=1.0" + +days_to_comorbidity: + common: + description: >- + Number of days between the date used for index and the date the patient was + diagnosed with a comorbidity. + termDef: + term: >- + Index Date To Comorbidity Day Count + source: caDSR + cde_id: 6154729 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154729%20and%20ver_nr=1.0" + +days_to_consent: + common: + description: >- + Number of days between the date used for index and the date the subject consent + was obtained for participation in the study. + termDef: + term: >- + Index Date to Consent Day Count + source: + cde_id: + cde_version: + term_url: + +days_to_death: + common: + description: >- + Number of days between the date used for index and the date from a person's + date of death represented as a calculated number of days. + termDef: + term: >- + Index Date to Death Day Count + source: caDSR + cde_id: 6154724 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154724%20and%20ver_nr=1.0" + +days_to_diagnosis: + common: + description: >- + Number of days between the date used for index and the date the patient was + diagnosed with the malignant disease. + termDef: + term: >- + Index Date To Disease Diagnosis Day Count + source: caDSR + cde_id: 6154733 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154733%20and%20ver_nr=1.0" + +days_to_first_event: + common: + description: >- + The number of days from the index date to the date of the first event. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +days_to_follow_up: + common: + description: >- + Number of days between the date used for index and the date of the patient's + last follow-up appointment or contact. + termDef: + term: >- + Index Date To Follow-up Day Count + source: caDSR + cde_id: 6154727 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154727%20and%20ver_nr=1.0" + +days_to_imaging: + common: + description: >- + Number of days between the date used for index and the date the imaging or scan + was performed on the patient. + termDef: + term: >- + Index Date To Imaging Day Count + source: + cde_id: + cde_version: + term_url: + +days_to_last_follow_up: + common: + description: >- + Time interval from the date of last follow up to the date of initial pathologic + diagnosis, represented as a calculated number of days. + termDef: + term: >- + Last Communication Contact Less Initial Pathologic Diagnosis Date Calculated + Day Value + source: caDSR + cde_id: 3008273 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3008273%20and%20ver_nr=1.0" + +days_to_last_known_disease_status: + common: + description: >- + Number of days between the date used for index and the date the patient's disease + status was known. + termDef: + term: >- + Last Communication Contact Less Initial Pathologic Diagnosis Date Calculated + Day Value + source: caDSR + cde_id: 3008273 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3008273%20and%20ver_nr=1.0" + +days_to_lost_to_followup: + common: + description: >- + The number of days between the date used for index and to the date the patient + was lost to follow-up. + termDef: + term: >- + Index Date To Lost To Follow-up Day Count + source: caDSR + cde_id: 6154721 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154721%20and%20ver_nr=1.0" + +days_to_progression: + common: + description: >- + Number of days between the date used for index and the date the patient's disease + progressed. + termDef: + term: >- + Index Date To Progression Day Count + source: caDSR + cde_id: 6154730 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154730%20and%20ver_nr=1.0" + +days_to_progression_free: + common: + description: >- + Number of days between the date used for index and the date the patient's disease + was formally confirmed as progression-free. + termDef: + term: >- + Index Date To Progression Free Day Count + source: caDSR + cde_id: + cde_version: + term_url: + +days_to_recurrence: + common: + description: >- + Number of days between the date used for index and the date the patient's disease + recurred. + termDef: + term: >- + Index Date To Recurrence Day Count + source: caDSR + cde_id: 6154731 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154731%20and%20ver_nr=1.0" + +days_to_risk_factor: + common: + description: >- + The number of days from the index date to the date the patient was diagnosed + with a specific risk factor. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +days_to_sample_procurement: + common: + description: >- + The number of days from the index date to the date a patient underwent a procedure + (e.g. surgical resection) to yield or remove from the patient a sample that + was eventually used for research. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +days_to_sequencing: + common: + description: >- + Number of days between the date used for index and the date the read group was + sequenced. + termDef: + term: >- + Days to Sequencing + source: + cde_id: + cde_version: + term_url: + +days_to_test: + common: + description: >- + Number of days between the date used for index and the date of the laboratory + test. + termDef: + term: >- + Index Date to Laboratory Test + source: + cde_id: + cde_version: + term_url: + +days_to_treatment_end: + common: + description: >- + Number of days between the date used for index and the date the treatment ended. + termDef: + term: >- + Index Date To Treatment End Day Count + source: caDSR + cde_id: 6154725 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154725%20and%20ver_nr=1.0" + +days_to_treatment_start: + common: + description: >- + Number of days between the date used for index and the date the treatment started. + termDef: + term: >- + Index Date To Treatment Start Day Count + source: caDSR + cde_id: 6154726 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154726%20and%20ver_nr=1.0" + +diabetes_treatment_type: + common: + description: >- + Text term used to describe the types of treatment used to manage diabetes. + termDef: + term: >- + Diabetes Mellitus Treatment Type + source: caDSR + cde_id: 3587247 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3587247%20and%20ver_nr=1.0" + +diagnosis_is_primary_disease: + common: + description: >- + Indicates whether this specific diagnosis represents the disease that was the + primary focus of the study. Additionally, this diagnosis is reflected at the + case level, which is captured using the case.disease_type property. + termDef: + term: >- + Is Diagnosis Primary Disease + source: + cde_id: + cde_version: + term_url: + +diagnosis_pathologically_confirmed: + common: + description: >- + The histologic description of tissue or cells confirmed by a pathology review + of frozen or formalin fixed slide(s) completed after the diagnostic pathology + review of the tumor sample used to extract analyte(s). + termDef: + term: >- + Post-Diagnostic Pathology Review Confirmation + source: + cde_id: + cde_version: + term_url: + +disease_response: + common: + description: >- + Code assigned to describe the patient's response or outcome to the disease. + termDef: + term: >- + Disease Response Code + source: caDSR + cde_id: 5750671 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5750671%20and%20ver_nr=1.0" + +disease_type: + common: + description: >- + The text term used to describe the type of malignant disease, as categorized + by the World Health Organization's (WHO) International Classification of Diseases + for Oncology (ICD-O). + termDef: + term: >- + ICD-O Disease Diagnosis Category + source: caDSR + cde_id: 6161017 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161017%20and%20ver_nr=1.0" + +distance_normal_to_tumor: + common: + description: >- + Text term to signify the distance between the tumor tissue and the normal control + tissue that was procured for matching normal DNA. + termDef: + term: >- + Tumor To Normal Control Tissue DNA Distance Category + source: caDSR + cde_id: 3088708 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3088708%20and%20ver_nr=1.0" + +distributor_reference: + common: + description: >- + Distributor reference number for cancer model. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +dlco_ref_predictive_percent: + common: + description: >- + The value, as a percentage of predicted lung volume, measuring the amount of + carbon monoxide detected in a patient's lungs. + termDef: + term: >- + Lung Carbon Monoxide Diffusing Capability Test Assessment Predictive Value + Percentage Value + source: caDSR + cde_id: 2180255 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2180255%20and%20ver_nr=1.0" + +double_expressor_lymphoma: + common: + description: >- + An immunohistochemical finding indicating the presence of double expression + of MYC and BCL2 proteins in the neoplastic cells of a tumor sample. + termDef: + term: + source: NCIt + cde_id: C138900 + cde_version: 22.05e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C138900" + +double_hit_lymphoma: + common: + description: >- + A rare B-cell non-Hodgkin lymphoma that is characterized by the abnormal rearrangement + of two genes, MYC gene and either BCL2 or BCL6 genes. Patients with this type + of lymphoma usually respond poorly to standard treatments and have a poor prognosis. + termDef: + term: + source: NCIt + cde_id: C125904 + cde_version: 22.05e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125904" + +drug_category: + common: + description: >- + A broad categorization of the type of drug administered. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +dysplasia_degree: + common: + description: >- + The degree to which dysplasia was involved. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +dysplasia_type: + common: + description: >- + The type of dysplasia involved. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +ecog_performance_status: + common: + description: >- + The ECOG functional performance status of the patient/participant. + termDef: + term: >- + Performance Status Assessment Eastern Cooperative Oncology Group Scale + source: caDSR + cde_id: 88 + cde_version: 5.1 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=88%20and%20ver_nr=5.1" + +eln_risk_classification: + common: + description: >- + A recommended risk stratification system used to provide prognostic information + in AML patients undergoing chemotherapy as well as allogeneic hematopoietic + stem cell transplantation. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +embolic_agent: + common: + description: >- + A substance used to block an artery, thereby eliminating the blood flow to a + specific part of an organ. An embolic agent may cause permanent or temporary + blockage depending on the nature of the material used. + termDef: + term: + source: NCIt + cde_id: C97229 + cde_version: 22.05e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97229" + +encoding: + common: + description: >- + The version of ASCII used to encode the read group quality control data. + termDef: + term: >- + ASCII Encoding Version for Read Group QC + source: NCIt + cde_id: C181705 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C181705" + term_id: C181705 + term_version: 23.11d + +enneking_msts_grade: + common: + description: >- + The text term used to describe the surgical grade of the musculoskeletal sarcoma, + using the Enneking staging system approved by the Musculoskeletal Tumor Society + (MSTS). + termDef: + term: >- + Enneking Musculoskeletal Tumor Society System Surgical Grade + source: caDSR + cde_id: 6003955 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6003955%20and%20ver_nr=2.0" + +enneking_msts_metastasis: + common: + description: >- + Text term and code that represents the metastatic stage of the musculoskeletal + sarcoma, using the Enneking staging system approved by the Musculoskeletal Tumor + Society (MSTS). + termDef: + term: >- + Enneking Musculoskeletal Tumor Society Staging System Metastasis Stage + source: caDSR + cde_id: 6003958 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6003958%20and%20ver_nr=1.0" + +enneking_msts_stage: + common: + description: >- + Text term used to describe the stage of the musculoskeletal sarcoma, using the + Enneking staging system approved by the Musculoskeletal Tumor Society (MSTS). + termDef: + term: >- + Enneking Musculoskeletal Tumor Society Staging System Stage + source: caDSR + cde_id: 6060045 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6060045%20and%20ver_nr=1.0" + +enneking_msts_tumor_site: + common: + description: >- + Text term and code that represents the tumor site of the musculoskeletal sarcoma, + using the Enneking staging system approved by the Musculoskeletal Tumor Society + (MSTS). + termDef: + term: >- + Enneking Musculoskeletal Tumor Society Staging System Tumor Stage + source: caDSR + cde_id: 6003957 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6003957%20and%20ver_nr=1.0" + +environmental_tobacco_smoke_exposure: + common: + description: >- + The yes/no/unknown indicator used to describe whether a patient was exposed + to smoke that is emitted from burning tobacco, including cigarettes, pipes, + and cigars. This includes tobacco smoke exhaled by smokers. + termDef: + term: >- + Person Environmental Tobacco Smoke Exposure Indicator + source: caDSR + cde_id: + cde_version: + term_url: + +esophageal_columnar_dysplasia_degree: + common: + description: >- + Text term to describe the amount of dysplasia found within the benign esophageal + columnar mucosa. + termDef: + term: >- + Non-cancerous Esophageal Columnar Mucosa Dysplasia Grade Result + source: caDSR + cde_id: 3440917 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440917%20and%20ver_nr=1.0" + +esophageal_columnar_metaplasia_present: + common: + description: >- + The yes/no/unknown indicator used to describe whether esophageal columnar metaplasia + was determined to be present. + termDef: + term: >- + Esophageal Columnar Metaplasia Present Indicator + source: caDSR + cde_id: 3440218 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440218%20and%20ver_nr=1.0" + +ethnicity: + common: + description: >- + An individual's self-described social and cultural grouping, specifically whether + an individual describes themselves as Hispanic or Latino. The provided values + are based on the categories defined by the U.S. Office of Management and Business + and used by the U.S. Census Bureau. + termDef: + term: >- + Ethnic Group Category Text + source: caDSR + cde_id: 2192217 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2192217%20and%20ver_nr=2.0" + +evidence_of_progression_type: + common: + description: >- + The text term used to describe the type of evidence used to determine whether + the patient's disease progressed. + termDef: + term: >- + Progression Evidence Type + source: + cde_id: + cde_version: + term_url: + +evidence_of_recurrence_type: + common: + description: >- + The text term used to describe the type of evidence used to determine whether + the patient's disease recurred. + termDef: + term: >- + Recurrence Evidence Type + source: + cde_id: + cde_version: + term_url: + +exon: + common: + description: >- + Exon number targeted or included in a molecular analysis. If a specific genetic + variant is being reported, this property can be used to capture the exon where + that variant is located. + termDef: + term: >- + Molecular Laboratory Procedure Exon Identification Number + source: caDSR + cde_id: 6142411 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142411%20and%20ver_nr=1.0" + +experiment_name: + common: + description: >- + Submitter-defined name for the experiment. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +experimental_protocol_type: + common: + description: >- + The type of experiment used to extract the analyte. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +experimental_strategy: + common: + description: >- + The sequencing strategy used to generate the data file. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +exposure_duration: + common: + description: >- + Text term used to describe the length of time the patient was exposed to an + environmental factor. + termDef: + term: >- + Patient Exposure Duration + source: + cde_id: + cde_version: + term_url: + +exposure_duration_years: + common: + description: >- + The period of time from start to finish of exposure, in years. + termDef: + term: >- + Exposure Duration + source: NCIt + cde_id: C83280 + cde_version: 21.04d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C83280" + +exposure_source: + common: + description: >- + The source or location where the patient was exposed. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +exposure_type: + common: + description: >- + The text term used to describe the type of environmental exposure. + termDef: + term: >- + Patient Exposure Type + source: + cde_id: + cde_version: + term_url: + +extracapsular_extension: + common: + description: >- + The extension of malignant tissue situated outside of a specific capsule. + termDef: + term: >- + Extracapsular + source: NCIt + cde_id: C25502 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25502" + +extranodal_extension: + common: + description: >- + Extension of a malignant neoplasm beyond the lymph node capsule. + termDef: + term: >- + Extranodal Involvement + source: NCIt + cde_id: C117309 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C117309" + +extrascleral_extension: + common: + description: >- + Spread of uveal melanoma beyond the sclera. + termDef: + term: >- + Extrascleral Extension of Uveal Melanoma + source: NCIt + cde_id: C111028 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111028" + +eye_color: + common: + description: >- + The color of the iris of the eye + termDef: + term: >- + Eye Color + source: NCIt + cde_id: C157437 + cde_version: 21.04d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157437" + +fab_morphology_code: + common: + description: >- + A classification system for acute myeloid leukemias, acute lymphoblastic leukemias, + and myelodysplastic syndromes. It is based on the morphologic and cytochemical + evaluation of bone marrow and peripheral blood smears. + termDef: + term: >- + French-American-British Classification + source: NCIt + cde_id: C91220 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111028" + +fastq_name: + common: + description: >- + Names of FASTQs. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +fev1_fvc_post_bronch_percent: + common: + description: >- + Percentage value to represent result of Forced Expiratory Volume in 1 second + (FEV1) divided by the Forced Vital Capacity (FVC) post-bronchodilator. + termDef: + term: >- + Post Bronchodilator FEV1/FVC Percent Value + source: caDSR + cde_id: 3302956 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3302956%20and%20ver_nr=1.0" + +fev1_fvc_pre_bronch_percent: + common: + description: >- + Percentage value to represent result of Forced Expiratory Volume in 1 second + (FEV1) divided by the Forced Vital Capacity (FVC) pre-bronchodilator. + termDef: + term: >- + Pre Bronchodilator FEV1/FVC Percent Value + source: caDSR + cde_id: 3302955 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3302955%20and%20ver_nr=1.0" + +fev1_ref_post_bronch_percent: + common: + description: >- + The percentage comparison to a normal value reference range of the volume of + air that a patient can forcibly exhale from the lungs in one second post-bronchodilator. + termDef: + term: >- + Post Bronchodilator Lung Forced Expiratory Volume 1 Test Lab Percentage Value + source: caDSR + cde_id: 3302948 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3302948%20and%20ver_nr=1.0" + +fev1_ref_pre_bronch_percent: + common: + description: >- + The percentage comparison to a normal value reference range of the volume of + air that a patient can forcibly exhale from the lungs in one second pre-bronchodilator. + termDef: + term: >- + Pre Bronchodilator Lung Forced Expiratory Volume 1 Test Lab Percentage Value + source: caDSR + cde_id: 3302947 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3302947%20and%20ver_nr=1.0" + +figo_stage: + common: + description: >- + The extent of a cervical or endometrial cancer within the body, especially whether + the disease has spread from the original site to other parts of the body, as + described by the International Federation of Gynecology and Obstetrics (FIGO) + stages. + termDef: + term: >- + Gynecologic Tumor Grouping Cervical Endometrial FIGO 2009 Stage + source: caDSR + cde_id: 3225684 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3225684%20and%20ver_nr=1.0" + +figo_staging_edition_year: + common: + description: >- + The text term used to describe the edition year of the FIGO staging system used + to stage the patient's gynecologic tumor. + termDef: + term: >- + FIGO + source: + cde_id: + cde_version: + term_url: + +file_name: + common: + description: >- + The name (or part of a name) of a file (of any type). + termDef: + term: >- + Electronic File Name + source: NCIt + cde_id: C171191 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171191" + term_id: C171191 + term_version: 23.11d + +file_size: + common: + description: >- + The size of the data file (object) in bytes. + termDef: + term: >- + Electronic File Size + source: NCIt + cde_id: C171192 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171192" + term_id: C171192 + term_version: 23.11d + +file_state: + common: + description: >- + The current state of the data file object. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +first_event: + common: + description: >- + Describes the patient's first event after initial treatment. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +first_symptom_prior_to_diagnosis: + common: + description: >- + Text term used to describe the patient's first symptom experienced prior to + diagnosis and thought to be related to the disease. + termDef: + term: >- + DiseaseFirst Symptom Type + source: caDSR + cde_id: 6133605 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6133605%20and%20ver_nr=1.0" + +flow_cell_barcode: + common: + description: >- + Flow cell barcode. Wrong or missing information may affect analysis results. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +fragment_maximum_length: + common: + description: >- + Maximum length of the sequenced fragments (e.g., as predicted by Agilent Bioanalyzer). + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +fragment_mean_length: + common: + description: >- + Mean length of the sequenced fragments (e.g., as predicted by Agilent Bioanalyzer). + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +fragment_minimum_length: + common: + description: >- + Minimum length of the sequenced fragments (e.g., as predicted by Agilent Bioanalyzer). + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +fragment_standard_deviation_length: + common: + description: >- + Standard deviation of the sequenced fragments length (e.g., as predicted by + Agilent Bioanalyzer). + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +fragmentation_enzyme: + common: + description: >- + The restriction enzyme used for nucleotide fragmentation. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +freezing_method: + common: + description: >- + Text term that represents the method used for freezing the sample. + termDef: + term: >- + Tissue Sample Freezing Method Type + source: caDSR + cde_id: 5432607 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432607%20and%20ver_nr=1.0" + +gastric_esophageal_junction_involvement: + common: + description: >- + The yes/no/unknown/not reported indicator used to describe whether the tumor + is located across the gastroesophageal junction. + termDef: + term: >- + Esophageal Tumor Across Gastroesophageal Junction Indicator + source: caDSR + cde_id: 6059632 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6059632%20and%20ver_nr=1.0" + +gender: + common: + description: >- + Text designations that identify gender. Gender is described as the assemblage + of properties that distinguish people on the basis of their societal roles. + [Explanatory Comment 1: Identification of gender is based upon self-report and + may come from a form, questionnaire, interview, etc.] + termDef: + term: >- + Person Gender Text Type + source: caDSR + cde_id: 2200604 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2200604%20and%20ver_nr=3.0" + +gene_symbol: + common: + description: >- + The text term used to describe a gene targeted or included in molecular analysis. + For rearrangements, this should be used to represent the reference gene. + termDef: + term: >- + Molecular Analysis Gene Symbol Code + source: caDSR + cde_id: 6142392 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142392%20and%20ver_nr=1.0" + +gleason_grade_group: + common: + description: >- + The text term used to describe the overall grouping of grades defined by the + Gleason grading classification, which is used to determine the aggressiveness + of prostate cancer. Note that this grade describes the entire prostatectomy + specimen and is not specific to the sample used for sequencing. + termDef: + term: >- + Gleason Score Grading System Group Category + source: caDSR + cde_id: 5918370 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5918370%20and%20ver_nr=1.0" + +gleason_grade_tertiary: + common: + description: >- + The text term used to describe the tertiary pattern as described by the Gleason + Grading System. + termDef: + term: >- + Gleason Tertiary Score For Prostate Cancer Category + source: NCIt + cde_id: C48605 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48605" + term_id: C48605 + term_version: 19.12e + +gleason_patterns_percent: + common: + description: >- + Numeric value that represents the percentage of Patterns 4 and 5, which is used + when the Gleason score is greater than 7 to predict prognosis. + termDef: + term: >- + Gleason Pattern Percent For Prostate Cancer Category + source: + cde_id: + cde_version: + term_url: + +gleason_score: + common: + description: >- + The score derived from universally embraced prostate cancer grading system developed + by Dr. Donald F. Gleason in 1977. The system provides a reproducible description + of the glandular architecture of prostate tissue to which a pathologist assigns + a score depending primarily on the microscopic patterns of cancerous glands + and cell morphology + termDef: + term: >- + Gleason Score for Prostate Cancer + source: NCIt + cde_id: C28084 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28084" + +goblet_cells_columnar_mucosa_present: + common: + description: >- + The yes/no/unknown indicator used to describe whether goblet cells were determined + to be present in the esophageal columnar mucosa. + termDef: + term: >- + Esophageal Columnar Mucosa Goblet Cell Present Indicator + source: caDSR + cde_id: 3440219 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440219%20and%20ver_nr=1.0" + +greatest_tumor_dimension: + common: + description: >- + Numeric value that represents the measurement of the widest portion of the tumor + in centimeters. + termDef: + term: >- + Tumor Longest Dimension Centimeters Measurement + source: NCIt + cde_id: C157135 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157135" + term_id: C157135 + term_version: 19.12e + +gross_tumor_weight: + common: + description: >- + Numeric value used to describe the gross pathologic tumor weight, measured in + grams. + termDef: + term: >- + Tumor Tissue Weight Number + source: caDSR + cde_id: 6133606 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6133606%20and%20ver_nr=1.0" + +growth_rate: + common: + description: >- + Rate at which the model grows, measured as hours to time to split. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +haart_treatment_indicator: + common: + description: >- + The text term used to indicate whether the patient received Highly Active Antiretroviral + Therapy (HAART). + termDef: + term: >- + HAART Therapy Indicator + source: + cde_id: + cde_version: + term_url: + +height: + common: + description: >- + The height of the patient in centimeters. + termDef: + term: >- + Patient Height Measurement + source: caDSR + cde_id: 649 + cde_version: 4.1 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=649%20and%20ver_nr=4.1" + +hepatitis_sustained_virological_response: + common: + description: >- + An indication as to whether sustained virological response was obtained in responses + to viral hepatitis treatment. + termDef: + term: >- + Viral Hepatitis Sustained Virologic Response Post Treatment Indicator + source: caDSR + cde_id: 6423783 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6423783%20and%20ver_nr=1.0" + +histone_family: + common: + description: >- + The text term used to describe the family, or classification of a group of basic + proteins found in chromatin, called histones. + termDef: + term: >- + Molecular Laboratory Procedure Histone Family Category + source: caDSR + cde_id: 6142511 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142511%20and%20ver_nr=1.0" + +histone_variant: + common: + description: >- + The text term used to describe a specific histone variants, which are proteins + that substitute for the core canonical histones. + termDef: + term: >- + Molecular Laboratory Procedure Histone Family Variant Type + source: caDSR + cde_id: 6142515 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142515%20and%20ver_nr=1.0" + +history_of_tumor: + common: + description: >- + Indicates whether patient has a history of tumors. + termDef: + term: >- + History of Tumor + source: + cde_id: + cde_version: + term_url: + +history_of_tumor_type: + common: + description: >- + Describes the type of the patient's prior diagnosed tumor. + termDef: + term: >- + Type of Prior Tumor + source: + cde_id: + cde_version: + term_url: + +hiv_viral_load: + common: + description: >- + Numeric value that represents the concentration of an analyte or aliquot extracted + from the sample or sample portion, measured in milligrams per milliliter. + termDef: + term: >- + Human Immunodeficiency Virus Viral Load Value + source: caDSR + cde_id: 2649682 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2649682%20and%20ver_nr=1.0" + +hormonal_contraceptive_type: + common: + description: >- + The specific type of hormonal contraceptives used by the subject. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +hormonal_contraceptive_use: + common: + description: >- + The text term used to indicate whether the patient used hormonal contraceptives. + termDef: + term: >- + Hormonal Contraceptive Use Text Term + source: + cde_id: + cde_version: + term_url: + +hormone_replacement_therapy_type: + common: + description: >- + The specific type of hormone replacement therapy received by the patient. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +hpv_positive_type: + common: + description: >- + Text classification to represent the strain or type of human papillomavirus + identified in an individual. + termDef: + term: >- + Human Papillomavirus Type + source: caDSR + cde_id: 2922649 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2922649%20and%20ver_nr=1.0" + +hpv_strain: + common: + description: >- + The specific hpv strain being tested. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +hysterectomy_margins_involved: + common: + description: >- + The text term used to indicate whether the patient's disease was determined + to be involved based on the surgical margins of the hysterectomy. + termDef: + term: >- + Hysterectomy Margins Involved + source: + cde_id: + cde_version: + term_url: + +hysterectomy_type: + common: + description: >- + The text term used to describe the type of hysterectomy the patient had. + termDef: + term: >- + Patient Hysterectomy Type + source: + cde_id: + cde_version: + term_url: + +icd_10_code: + common: + description: >- + Alphanumeric value used to describe the disease code from the tenth version + of the International Classification of Disease (ICD-10). + termDef: + term: >- + International Classification of Disease, Tenth Revision Code + source: caDSR + cde_id: 3226287 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3226287%20and%20ver_nr=2.0" + +igcccg_stage: + common: + description: >- + The text term used to describe the International Germ Cell Cancer Collaborative + Group (IGCCCG), a grouping used to further classify metastatic testicular tumors. + termDef: + term: >- + IGCCCG Stage Group + source: caDSR + cde_id: + cde_version: + term_url: + +imaging_anatomic_site: + common: + description: >- + The named location(s) within the body where an image was taken. + termDef: + term: >- + Anatomic Site + source: NCIt + cde_id: C13717 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13717" + +imaging_findings: + common: + description: >- + Recorded findings noted during the review of a specific medical image. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +imaging_result: + common: + description: >- + The text term used to describe the result of the imaging or scan performed on + the patient. + termDef: + term: >- + Imaging Result + source: + cde_id: + cde_version: + term_url: + +imaging_suv: + common: + description: >- + The standardized update value (SUV) is the effectively dimensionless measure + of regional tracer uptake calculated as the activity concentration within a + 2D region of interest (ROI) or 3D volume of interest (VOI) measured on a PET + image (nCi1mL) / [injected dose (nCi) / body weight (g)]. + termDef: + term: >- + Standardized Uptake Value + source: NCIt + cde_id: C69310 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C69310" + +imaging_suv_max: + common: + description: >- + The standardized update value (SUV) is the effectively dimensionless measure + of regional tracer uptake calculated as the activity concentration within a + 2D region of interest (ROI) or 3D volume of interest (VOI) measured on a PET + image (nCi1mL) / [injected dose (nCi) / body weight (g)]. Specifically, the + maximum SUV recorded for a patient. + termDef: + term: >- + Standardized Uptake Value + source: NCIt + cde_id: C69310 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C69310" + +imaging_type: + common: + description: >- + The text term used to describe the type of imaging or scan performed on the + patient. + termDef: + term: >- + Imaging Type + source: + cde_id: + cde_version: + term_url: + +immunosuppressive_treatment_type: + common: + description: >- + The text term used to describe the type of immunosuppressive treatment the patient + received. + termDef: + term: >- + Immunosuppresive Treatment Type + source: + cde_id: + cde_version: + term_url: + +includes_spike_ins: + common: + description: >- + Spike-in included? + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +index_date: + common: + description: >- + The text term used to describe the reference or anchor date used when for date + obfuscation, where a single date is obscurred by creating one or more date ranges + in relation to this date. + termDef: + term: >- + Index Date Type + source: caDSR + cde_id: 6154722 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6154722%20and%20ver_nr=1.0" + +initial_disease_status: + common: + description: >- + The text term used to describe the status of the patient's malignancy when the + treatment began. + termDef: + term: >- + Initial Disease Status Type + source: caBIG + cde_id: + cde_version: + term_url: + +initial_weight: + common: + description: >- + Numeric value that represents the initial weight of the sample, measured in + milligrams. + termDef: + term: >- + Tissue Sample Initial Weight Milligram Value + source: caDSR + cde_id: 5432605 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432605%20and%20ver_nr=1.0" + +inpc_grade: + common: + description: >- + Text term used to describe the classification of neuroblastic differentiation + within neuroblastoma tumors, as defined by the International Neuroblastoma Pathology + Classification (INPC). + termDef: + term: >- + International Neuroblastoma Pathology Classification Grade Category + source: caDSR + cde_id: 6133602 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6133602%20and%20ver_nr=1.0" + +inpc_histologic_group: + common: + description: >- + The text term used to describe the classification of neuroblastomas distinguishing + between favorable and unfavorable histologic groups. The histologic score, defined + by the International Neuroblastoma Pathology Classification (INPC), is based + on age, mitosis-karyorrhexis index (MKI), stromal content and degree of tumor + cell differentiation. + termDef: + term: >- + International Neuroblastoma Pathology Classification Histology Score Category + source: caDSR + cde_id: 4616372 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4616372%20and%20ver_nr=1.0" + +inrg_stage: + common: + description: >- + The text term used to describe the staging classification of neuroblastic tumors, + as defined by the International Neuroblastoma Risk Group (INRG). + termDef: + term: >- + Patient International Neuroblastoma Risk Group Classification System Stage + source: caDSR + cde_id: 5777238 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5777238%20and%20ver_nr=1.0" + +inss_stage: + common: + description: >- + Text term used to describe the staging classification of neuroblastic tumors, + as defined by the International Neuroblastoma Staging System (INSS). + termDef: + term: >- + International Neuroblastoma Staging System Stage + source: caDSR + cde_id: 6133603 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6133603%20and%20ver_nr=1.0" + +instrument_model: + common: + description: >- + Specific model of sequencing instrument used. + termDef: + term: >- + Tissue Sample Intermediate Dimension Millimeter Measurement + source: caDSR + cde_id: 5432604 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432604%20and%20ver_nr=1.0" + +intermediate_dimension: + common: + description: >- + Intermediate dimension of the sample, in millimeters. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +international_prognostic_index: + common: + description: >- + The text term used to describe the International Prognostic Index, which classifies + the prognosis of patients with aggressive non-Hodgkin's lymphoma. + termDef: + term: >- + Patient International Prognostic Index Risk Category + source: caDSR + cde_id: 2500234 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2500234%20and%20ver_nr=1.0" + +intron: + common: + description: >- + Intron number targeted or included in molecular analysis. If a specific genetic + variant is being reported, this property can be used to capture the intron where + that variant is located. + termDef: + term: >- + Molecular Laboratory Procedure Intron Identifier + source: caDSR + cde_id: 6514355 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6514355%20and%20ver_nr=1.0" + +irs_group: + common: + description: >- + Text term used to describe the classification of rhabdomyosarcoma tumors, as + defined by the Intergroup Rhabdomyosarcoma Study (IRS). + termDef: + term: >- + Intergroup Rhabdomyosarcoma Study Group Stage + source: caDSR + cde_id: 6141658 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6141658%20and%20ver_nr=1.0" + +irs_stage: + common: + description: >- + The text term used to describe the classification of rhabdomyosarcoma tumors, + as defined by the Intergroup Rhabdomyosarcoma Study (IRS). + termDef: + term: >- + Rhabdomyosarcoma Diagnosis Assessment Stage + source: caDSR + cde_id: 5162089 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5162089%20and%20ver_nr=1.0" + +is_ffpe: + common: + description: >- + Indicator to signify whether or not the tissue sample was fixed in formalin + and embedded in paraffin (FFPE). + termDef: + term: >- + Specimen Processing Formalin Fixed Paraffin Embedded Tissue Indicator + source: caDSR + cde_id: 4170557 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4170557%20and%20ver_nr=1.0" + +is_paired_end: + common: + description: >- + Are the reads paired end? + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +ishak_fibrosis_score: + common: + description: >- + The text term used to describe the classification of the histopathologic degree + of liver damage. + termDef: + term: >- + Liver Fibrosis Ishak Score Category + source: caDSR + cde_id: 3182621 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3182621%20and%20ver_nr=1.0" + +iss_stage: + common: + description: >- + The multiple myeloma disease stage at diagnosis. + termDef: + term: >- + Multiple Myeloma Disease Stage Diagnosis Status + source: caDSR + cde_id: 2465385 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2465385%20and%20ver_nr=1.0" + +karnofsky_performance_status: + common: + description: >- + Text term used to describe the classification used of the functional capabilities + of a person. + termDef: + term: >- + Karnofsky Performance Status Score + source: caDSR + cde_id: 2003853 + cde_version: 4.2 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2003853%20and%20ver_nr=4.2" + +laboratory_test: + common: + description: >- + The text term used to describe the medical testing used to diagnose, treat or + further understand a patient's disease. + termDef: + term: >- + Laboratory Test Type + source: caBIG + cde_id: + cde_version: + term_url: + +lane_number: + common: + description: >- + The basic machine unit for sequencing. For Illumina machines, this reflects + the physical lane number. Wrong or missing information may affect analysis results. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +largest_extrapelvic_peritoneal_focus: + common: + description: >- + The text term used to describe the diameter of the largest focus originating + outside of the pelvic peritoneal region. + termDef: + term: >- + Neoplasm Largest External Pelvic Peritoneal Focus Diameter Measurement + source: caDSR + cde_id: 6690680 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6690680%20and%20ver_nr=1.0" + +last_known_disease_status: + common: + description: >- + Text term that describes the last known state or condition of an individual's + neoplasm. + termDef: + term: >- + Person Last Known Neoplasm Status + source: caDSR + cde_id: 5424231 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5424231%20and%20ver_nr=1.0" + +laterality: + common: + description: >- + For tumors in paired organs, designates the side on which the cancer originates. + termDef: + term: >- + Primary Tumor Laterality + source: caDSR + cde_id: 827 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=827%20and%20ver_nr=3.0" + +lesions_treated_number: + common: + description: >- + The number of lesions treated. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +library_name: + common: + description: >- + Name of the library. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +library_preparation_kit_catalog_number: + common: + description: >- + Catalog of Library Preparation Kit + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +library_preparation_kit_name: + common: + description: >- + Name of Library Preparation Kit + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +library_preparation_kit_vendor: + common: + description: >- + Vendor of Library Preparation Kit + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +library_preparation_kit_version: + common: + description: >- + Version of Library Preparation Kit + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +library_selection: + common: + description: >- + Library Selection Method + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +library_strand: + common: + description: >- + Library stranded-ness. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +library_strategy: + common: + description: >- + Library strategy. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +loci_abnormal_count: + common: + description: >- + Numeric value used to describe the number of loci determined to be abnormal. + termDef: + term: >- + Abnormal Locus Testing Count + source: caDSR + cde_id: 6074182 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6074182%20and%20ver_nr=1.0" + +loci_count: + common: + description: >- + Numeric value used to describe the number of loci tested. + termDef: + term: >- + Locus Testing Count + source: caDSR + cde_id: 6074183 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6074183%20and%20ver_nr=1.0" + +locus: + common: + description: >- + The position of a gene or a chromosomal marker on a chromosome; also, a stretch + of DNA at a particular place on a particular chromosome. The use of locus is + sometimes restricted to mean regions of DNA that are expressed. + termDef: + term: >- + Locus + source: NCIt + cde_id: C45822 + cde_version: 22.04d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=22.04d&ns=ncit&code=C45822&key=1930938629&b=1&n=null" + +longest_dimension: + common: + description: >- + Numeric value that represents the longest dimension of the sample, measured + in millimeters. + termDef: + term: >- + Tissue Sample Longest Dimension Millimeter Measurement + source: caDSR + cde_id: 5432602 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432602%20and%20ver_nr=1.0" + +lost_to_followup: + common: + description: >- + The yes/no/unknown indicator used to describe whether a patient was unable to + be contacted or seen for follow-up information. + termDef: + term: >- + Patient Lost Follow-up Indicator + source: caDSR + cde_id: 6161018 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161018%20and%20ver_nr=1.0" + +lymph_node_dissection_method: + common: + description: >- + The method employed to remove a lymph nodes(s) + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +lymph_node_dissection_site: + common: + description: >- + The named location(s) within the body where a lymph node(s) were removed. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +lymph_node_involved_site: + common: + description: >- + The text term used to describe the anatomic site of lymph node involvement. + termDef: + term: >- + Lymph Node Involved Site + source: NCIt + cde_id: C33027 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33027" + term_id: C33027 + term_version: 19.12e + +lymph_node_involvement: + common: + description: >- + Indicator noting whether lymph nodes were involved. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +lymph_nodes_positive: + common: + description: >- + The number of lymph nodes involved with disease as determined by pathologic + examination. + termDef: + term: >- + Lymph Node(s) Positive Number + source: caDSR + cde_id: 89 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=89%20and%20ver_nr=3.0" + +lymph_nodes_removed: + common: + description: >- + The number of lymph nodes removed during a biopsy or surgical procedure. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +lymph_nodes_tested: + common: + description: >- + The number of lymph nodes tested to determine whether lymph nodes were involved + with disease as determined by a pathologic examination. + termDef: + term: >- + Lymph Node Examined Count + source: caDSR + cde_id: 3 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3%20and%20ver_nr=3.0" + +lymphatic_invasion_present: + common: + description: >- + A yes/no indicator to ask if small or thin-walled vessel invasion is present, + indicating lymphatic involvement + termDef: + term: >- + Lymphatic/Small vessel Invasion Ind + source: caDSR + cde_id: 64171 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=64171%20and%20ver_nr=3.0" + +margin_distance: + common: + description: >- + Numeric value that represents the distance between the tumor and the surgical + margin + termDef: + term: >- + Distance to Margin Measurement + source: NCIt + cde_id: C137815 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137815" + term_id: C137815 + term_version: 19.12e + +margin_status: + common: + description: >- + The determination of the presence of actual or potential neoplastic tissue which + has been left outside the boundary of a resected specimen within the patient. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +margins_involved_site: + common: + description: >- + The text term used to describe the anatomic sites that were involved in the + survival margins. + termDef: + term: >- + Surgical Margins Involved Site + source: + cde_id: + cde_version: + term_url: + +marijuana_use_per_week: + common: + description: >- + Numeric value that represents the number of times the patient uses marijuana + each day. + termDef: + term: >- + Daily Marijuana Use Count + source: + cde_id: + cde_version: + term_url: + +masaoka_stage: + common: + description: >- + The text term used to describe the Masaoka staging system, a classification + that defines prognostic indicators for thymic malignancies and predicts tumor + recurrence. + termDef: + term: >- + Thymoma Masaoka Stage + source: caDSR + cde_id: 3952848 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3952848%20and%20ver_nr=1.0" + +max_tumor_bulk_site: + common: + description: >- + The site of the tumor where the dimension or diameter is larger than any other + part of the tumor. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +md5sum: + common: + description: >- + The 128-bit hash value expressed as a 32 digit hexadecimal number (in lower + case) used as a file's digital fingerprint. + termDef: + term: >- + MD5 Checksum + source: NCIt + cde_id: C171276 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171276" + term_id: C171276 + term_version: 23.11d + +mean_coverage: + common: + description: >- + Mean coverage for whole genome sequencing, or mean target coverage for whole + exome and targeted sequencing, collected from Picard Tools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +medulloblastoma_molecular_classification: + common: + description: >- + The text term used to describe the classification of medulloblastoma tumors + based on molecular features. + termDef: + term: >- + Medulloblastoma Genetic Finding Subclass Category + source: caDSR + cde_id: 6002209 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6002209%20and%20ver_nr=1.0" + +menopause_status: + common: + description: >- + Text term used to describe the patient's menopause status. + termDef: + term: >- + Patient Menopause Status + source: caDSR + cde_id: 2434914 + cde_version: 1.1 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2434914%20and%20ver_nr=1.1" + +metaplasia_present: + common: + description: >- + Indicator noting whether metaplasia was present. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +metastasis_at_diagnosis: + common: + description: >- + The text term used to describe the extent of metastatic disease present at diagnosis. + termDef: + term: >- + Metastatic Disease at Diagnosis Indicator + source: caDSR + cde_id: 6133614 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6133614%20and%20ver_nr=1.0" + +metastasis_at_diagnosis_site: + common: + description: >- + Text term to identify an anatomic site in which metastatic disease involvement + is found. + termDef: + term: >- + Metastatic Disease Anatomic Site Name + source: caDSR + cde_id: 3029815 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3029815%20and%20ver_nr=1.0" + +method_of_diagnosis: + common: + description: >- + Text term used to describe the method used to confirm the patients malignant + diagnosis. + termDef: + term: >- + Disease Method of Diagnosis Type + source: caDSR + cde_id: 6161031 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161031%20and%20ver_nr=1.0" + +method_of_sample_procurement: + common: + description: >- + The method used to procure the sample used to extract analyte(s). + termDef: + term: >- + Method of Sample Procurement + source: + cde_id: + cde_version: + term_url: + +micropapillary_features: + common: + description: >- + The yes/no/unknown indicator used to describe whether micropapillary features + were determined to be present. + termDef: + term: >- + Tumor Micropapillary Features Present Status + source: caDSR + cde_id: 6068784 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6068784%20and%20ver_nr=1.0" + +mismatch_repair_mutation: + common: + description: >- + The yes/no/unknown indicator used to describe whether the mutation included + in molecular testing was known to have an affect on the mismatch repair process. + termDef: + term: >- + Gene Mutation Mismatch Repair Indicator + source: caDSR + cde_id: 6142534 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142534%20and%20ver_nr=1.0" + +mitosis_karyorrhexis_index: + common: + description: >- + Text term that represents the component of the International Neuroblastoma Pathology + Classification (INPC) for mitosis-karyorrhexis index (MKI). + termDef: + term: >- + International Neuroblastoma Pathology Classification Mitosis Karyorrhexis + Index Category + source: caDSR + cde_id: 4616412 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4616412%20and%20ver_nr=1.0" + +mitotic_count: + common: + description: >- + The number of mitoses identified under the microscope in tumors. The method + of counting varies, according to the specific tumor examined. Usually, the mitotic + count is determined based on the number of mitoses per high power field (40X) + or 10 high power fields. + termDef: + term: >- + Mitotic Count + source: NCIt + cde_id: C47864 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47864" + +mitotic_total_area: + common: + description: >- + The total area reviewed when calculating the mitotic index ratio. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +molecular_analysis_method: + common: + description: >- + The text term used to describe the method used for molecular analysis. + termDef: + term: >- + Molecular Laboratory Procedure Method Name + source: caDSR + cde_id: 6142401 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142401%20and%20ver_nr=1.0" + +molecular_consequence: + common: + description: >- + The text term used to describe the molecular consequence of genetic variation. + termDef: + term: >- + Molecular Laboratory Procedure Outcome Consequence Type + source: caDSR + cde_id: 6142403 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142403%20and%20ver_nr=1.0" + +morphologic_architectural_pattern: + common: + description: >- + A specific morphologic or pathologic architectural pattern was discovered within + the sample studied. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +morphology: + common: + description: >- + The third edition of the International Classification of Diseases for Oncology, + published in 2000 used principally in tumor and cancer registries for coding + the site (topography) and the histology (morphology) of neoplasms. The study + of the structure of the cells and their arrangement to constitute tissues and, + finally, the association among these to form organs. In pathology, the microscopic + process of identifying normal and abnormal morphologic characteristics in tissues, + by employing various cytochemical and immunocytochemical stains. A system of + numbered categories for representation of data. + termDef: + term: >- + International Classification of Diseases for Oncology, Third Edition ICD-O-3 + Histology Code + source: caDSR + cde_id: 3226275 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3226275%20and%20ver_nr=1.0" + +multiplex_barcode: + common: + description: >- + The barcode/index sequence used. Wrong or missing information may affect analysis + results. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +mutation_codon: + common: + description: >- + The codon where a change in the nucleotide sequence is occurring and causing + an error. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +nadir_cd4_count: + common: + description: >- + Numeric value that represents the lowest point to which the CD4 count has dropped + (nadir). + termDef: + term: >- + CD4 Nadir Count + source: + cde_id: + cde_version: + term_url: + +necrosis_percent: + common: + description: >- + A quantitative measurement of the percent of cells undergoing necrosis compared + to the number of total cells present in a sample. + termDef: + term: >- + Percent of Necrosis + source: NCIt + cde_id: C159481 + cde_version: 20.10d + term_url: + term_id: C159481 + term_version: 20.10d + +necrosis_present: + common: + description: >- + Indicator describing whether the presence of necrosis was confirmed. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +no_matched_normal_low_pass_wgs: + common: + description: >- + There will be no matched normal low pass WGS aliquots for this case that can + be used for variant calling purposes. The GDC may elect to use a single tumor + calling pipeline to process this data. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +no_matched_normal_targeted_sequencing: + common: + description: >- + There will be no matched normal Targeted Sequencing aliquots for this case that + can be used for variant calling purposes. The GDC may elect to use a single + tumor calling pipeline to process this data. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +no_matched_normal_wgs: + common: + description: >- + There will be no matched normal WGS aliquots for this case that can be used + for variant calling purposes. The GDC may elect to use a single tumor calling + pipeline to process this data. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +no_matched_normal_wxs: + common: + description: >- + There will be no matched normal WXS aliquots for this case that can be used + for variant calling purposes. The GDC may elect to use a single tumor calling + pipeline to process this data. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +non_nodal_regional_disease: + common: + description: >- + The text term used to describe whether the patient had non-nodal regional disease. + termDef: + term: + source: caDSR + cde_id: + cde_version: + term_url: + +non_nodal_tumor_deposits: + common: + description: >- + The yes/no/unknown indicator used to describe the presence of tumor deposits + in the pericolic or perirectal fat or in adjacent mesentery away from the leading + edge of the tumor. + termDef: + term: >- + Resected Biospecimen NonNodal Tumor Deposits Indicator + source: caDSR + cde_id: 3107051 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3107051%20and%20ver_nr=1.0" + +normal_tumor_genotype_snp_match: + common: + description: >- + Text term that represents whether or not the genotype of the normal tumor matches + or if the data is not available. + termDef: + term: >- + Normal Tumor Genotype Match Indicator + source: caDSR + cde_id: 4588156 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4588156%20and%20ver_nr=1.0" + +number_expect_cells: + common: + description: >- + Expected number of recovered cells in droplet-based single-cell libraries. + termDef: + term: >- + Expected Cells Count + source: + cde_id: + cde_version: + term_url: + +number_of_cycles: + common: + description: >- + The numeric value used to describe the number of cycles of a specific treatment + or regimen the patient received. + termDef: + term: >- + Treatment Number of Cycles Count + source: + cde_id: + cde_version: + term_url: + +number_of_fractions: + common: + description: >- + The total number of divided radiation doses received. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +number_proliferating_cells: + common: + description: >- + Numeric value that represents the count of proliferating cells determined during + pathologic review of the sample slide(s). + termDef: + term: >- + Pathology Review Slide Proliferating Cell Count + source: caDSR + cde_id: 5432636 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432636%20and%20ver_nr=1.0" + +occupation_duration_years: + common: + description: >- + The number of years a patient worked in a specific occupation. + termDef: + term: >- + Person Occupation Years Number + source: caDSR + cde_id: 2435424 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2435424%20and%20ver_nr=1.0" + +occupation_type: + common: + description: >- + A categorization of the principal activity that a person does to earn money, + as defined by the International Classification of Occupation (ISCO). + termDef: + term: >- + Occupation + source: NCIt + cde_id: C25193 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25193" + +oct_embedded: + common: + description: >- + Indicator of whether or not the sample was embedded in Optimal Cutting Temperature + (OCT) compound. + termDef: + term: >- + Tissue Sample Optimal Cutting Temperature Compound Embedding Indicator + source: caDSR + cde_id: 5432538 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432538%20and%20ver_nr=1.0" + +ovarian_specimen_status: + common: + description: >- + The text term used to describe the physical condition of the involved ovary. + termDef: + term: >- + Ovarian Specimen Integrity Status + source: caDSR + cde_id: 6690671 + cde_version: + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6690671%20and%20ver_nr=" + +ovarian_surface_involvement: + common: + description: >- + The text term that describes whether the surface tissue (outer boundary) of + the ovary shows evidence of involvement or presence of cancer. + termDef: + term: >- + Ovary Surface Involvement Indicator + source: caDSR + cde_id: 6690674 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6690674%20and%20ver_nr=1.0" + +pack_years_smoked: + common: + description: >- + Numeric computed value to represent lifetime tobacco exposure defined as number + of cigarettes smoked per day x number of years smoked divided by 20. + termDef: + term: >- + Person Cigarette Smoking History Pack Year Value + source: caDSR + cde_id: 2955385 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2955385%20and%20ver_nr=1.0" + +pairs_on_diff_chr: + common: + description: >- + Pairs on different chromosomes collected from samtools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +pancreatitis_onset_year: + common: + description: >- + Numeric value to represent the year that the patient was diagnosed with clinical + chronic pancreatitis. + termDef: + term: >- + Chronic Pancreatitis Diagnosis Year Number + source: caDSR + cde_id: 3457763 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3457763%20and%20ver_nr=1.0" + +papillary_renal_cell_type: + common: + description: >- + The text term used to describe the type of papillary renal cell carcinoma characterized + by the presence of papillae covered by small cells with scant amount of cytoplasm. + termDef: + term: >- + Papillary Renal Cell Type Category + source: + cde_id: + cde_version: + term_url: + +parent_with_radiation_exposure: + common: + description: >- + Indicates whether the patient's parent(s) were exposed to radiation + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +passage_count: + common: + description: >- + Number of passages (splits) between the original tissue and this model. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +pathogenicity: + common: + description: >- + The text used to describe a variant's level of involvement in the cause of the + patient's disease according to the standards outlined by the American College + of Medical Genetics and Genomics (ACMG). + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +pediatric_kidney_staging: + common: + description: >- + A modified version of the Children's Oncology Group (COG) National Wilms Tumor + Study Group (NWTS) staging system. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +percent_eosinophil_infiltration: + common: + description: >- + Numeric value to represent the percentage of infiltration by eosinophils in + a tumor sample or specimen. + termDef: + term: >- + Specimen Eosinophilia Percentage Value + source: caDSR + cde_id: 2897700 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2897700%20and%20ver_nr=2.0" + +percent_follicular_component: + common: + description: >- + Numeric value that represents the percentage of follicular features found in + a specific tissue sample. + termDef: + term: >- + Specimen Follicular Features Percentage Value + source: + cde_id: + cde_version: + term_url: + +percent_gc_content: + common: + description: >- + The overall %GC of all bases in all sequences. + termDef: + term: >- + %GC + source: NCIt + cde_id: C181848 + cde_version: + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C181848" + +percent_granulocyte_infiltration: + common: + description: >- + Numeric value to represent the percentage of infiltration by granulocytes in + a tumor sample or specimen. + termDef: + term: >- + Specimen Granulocyte Infiltration Percentage Value + source: caDSR + cde_id: 2897705 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2897705%20and%20ver_nr=2.0" + +percent_inflam_infiltration: + common: + description: >- + Numeric value to represent local response to cellular injury, marked by capillary + dilatation, edema and leukocyte infiltration; clinically, inflammation is manifest + by reddness, heat, pain, swelling and loss of function, with the need to heal + damaged tissue. + termDef: + term: >- + Specimen Inflammation Change Percentage Value + source: caDSR + cde_id: 2897695 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2897695%20and%20ver_nr=1.0" + +percent_lymphocyte_infiltration: + common: + description: >- + Numeric value to represent the percentage of infiltration by lymphocytes in + a solid tissue sample or specimen. + termDef: + term: >- + Specimen Lymphocyte Infiltration Percentage Value + source: caDSR + cde_id: 2897710 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2897710%20and%20ver_nr=2.0" + +percent_monocyte_infiltration: + common: + description: >- + Numeric value to represent the percentage of monocyte infiltration in a sample + or specimen. + termDef: + term: >- + Specimen Monocyte Infiltration Percentage Value + source: caDSR + cde_id: 5455535 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5455535%20and%20ver_nr=1.0" + +percent_necrosis: + common: + description: >- + Numeric value to represent the percentage of cell death in a malignant tumor + sample or specimen. + termDef: + term: >- + Malignant Neoplasm Necrosis Percentage Value + source: caDSR + cde_id: 2841237 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2841237%20and%20ver_nr=1.0" + +percent_neutrophil_infiltration: + common: + description: >- + Numeric value to represent the percentage of infiltration by neutrophils in + a tumor sample or specimen. + termDef: + term: >- + Malignant Neoplasm Neutrophil Infiltration Percentage Cell Value + source: caDSR + cde_id: 2841267 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2841267%20and%20ver_nr=1.0" + +percent_normal_cells: + common: + description: >- + Numeric value to represent the percentage of normal cell content in a malignant + tumor sample or specimen. + termDef: + term: >- + Malignant Neoplasm Normal Cell Percentage Value + source: caDSR + cde_id: 2841233 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2841233%20and%20ver_nr=1.0" + +percent_rhabdoid_features: + common: + description: >- + Numeric value that represents the percentage of rhabdoid features found in a + specific tissue sample. + termDef: + term: >- + Specimen Rhabdoid Features Percentage Value + source: caDSR + cde_id: 6790120 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6790120%20and%20ver_nr=1.0" + +percent_sarcomatoid_features: + common: + description: >- + Numeric value that represents the percentage of sarcomatoid features found in + a specific tissue sample. + termDef: + term: >- + Specimen Sarcomatoid Features Percentage Value + source: caDSR + cde_id: 2429786 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2429786%20and%20ver_nr=1.0" + +percent_stromal_cells: + common: + description: >- + Numeric value to represent the percentage of reactive cells that are present + in a malignant tumor sample or specimen but are not malignant such as fibroblasts, + vascular structures, etc. + termDef: + term: >- + Malignant Neoplasm Stromal Cell Percentage Value + source: caDSR + cde_id: 2841241 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2841241%20and%20ver_nr=1.0" + +percent_tumor_cells: + common: + description: >- + Numeric value that represents the percentage of infiltration by tumor cells + in a sample. + termDef: + term: >- + Specimen Tumor Cell Percentage Value + source: caDSR + cde_id: 5432686 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432686%20and%20ver_nr=1.0" + +percent_tumor_invasion: + common: + description: >- + The percentage of tumor cells spread locally in a malignant neoplasm through + infiltration or destruction of adjacent tissue. + termDef: + term: + source: caDSR + cde_id: + cde_version: + term_url: + +percent_tumor_nuclei: + common: + description: >- + Numeric value to represent the percentage of tumor nuclei in a malignant neoplasm + sample or specimen. + termDef: + term: >- + Malignant Neoplasm Neoplasm Nucleus Percentage Cell Value + source: caDSR + cde_id: 2841225 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2841225%20and%20ver_nr=1.0" + +perineural_invasion_present: + common: + description: >- + a yes/no indicator to ask if perineural invasion or infiltration of tumor or + cancer is present. + termDef: + term: >- + Tumor Perineural Invasion Ind + source: caDSR + cde_id: 64181 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=64181%20and%20ver_nr=3.0" + +peripancreatic_lymph_nodes_positive: + common: + description: >- + Enumerated numeric value or range of values used to describe the number of peripancreatic + lymph nodes determined to be positive. + termDef: + term: >- + Peripancreatic Lymph Node Positive Finding Range + source: caDSR + cde_id: 5983082 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5983082%20and%20ver_nr=2.0" + +peripancreatic_lymph_nodes_tested: + common: + description: >- + The total number of peripancreatic lymph nodes tested for the presence of pancreatic + cancer cells. + termDef: + term: >- + Peripancreatic Lymph Node Examined Count + source: caDSR + cde_id: 6050944 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6050944%20and%20ver_nr=1.0" + +peritoneal_fluid_cytological_status: + common: + description: >- + The text term used to describe the malignant status of the peritoneal fluid + determined by cytologic testing. + termDef: + term: >- + Peritoneal Ascites Cytological Procedure Status + source: caDSR + cde_id: 6690681 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6690681%20and%20ver_nr=1.0" + +peritoneal_washing_results: + common: + description: >- + The results from this minimally invasive procedure that permits sampling of + peritoneal fluid for cytopathologic analysis. + termDef: + term: >- + Peritoneal Lavage + source: NCIt + cde_id: C159340 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C159340" + +plate_name: + common: + description: >- + User specified identifier of the plate used to prepare the sample for analysis. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +plate_well: + common: + description: >- + User specified identifier for the specific well of the plate used to prepare + the sample for analysis. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +platform: + common: + description: >- + Name of the platform used to obtain data. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +ploidy: + common: + description: >- + Text term used to describe the number of sets of homologous chromosomes. + termDef: + term: >- + Molecular Laboratory Procedure Ploidy Result Type + source: caDSR + cde_id: 6142527 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142527%20and%20ver_nr=1.0" + +portion_number: + common: + description: >- + Numeric value that represents the sequential number assigned to a portion of + the sample. + termDef: + term: >- + Biospecimen Portion Sequence Number + source: caDSR + cde_id: 5432711 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432711%20and%20ver_nr=1.0" + +portion_weight: + common: + description: >- + Numeric value that represents the sample portion weight, measured in milligrams. + termDef: + term: >- + Biospecimen Portion Weight Milligram Value + source: caDSR + cde_id: 5432593 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432593%20and%20ver_nr=1.0" + +pregnancy_count: + common: + description: >- + The number of times an individual has become pregnant. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +pregnancy_outcome: + common: + description: >- + The text term used to describe the type of pregnancy the patient had. + termDef: + term: >- + Patient Pregnancy Type + source: + cde_id: + cde_version: + term_url: + +pregnant_at_diagnosis: + common: + description: >- + The text term used to indicate whether the patient was pregnant at the time + they were diagnosed. + termDef: + term: >- + Pregnant at Diagnosis Indicator + source: + cde_id: + cde_version: + term_url: + +premature_at_birth: + common: + description: >- + The yes/no/unknown indicator used to describe whether the patient was premature + (less than 37 weeks gestation) at birth. + termDef: + term: >- + Premature Infant Birth Status Indicator + source: caDSR + cde_id: 6010765 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6010765%20and%20ver_nr=1.0" + +prescribed_dose: + common: + description: >- + A quantity of an agent prescribed to the study participant. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +preservation_method: + common: + description: >- + Text term that represents the method used to preserve the sample. + termDef: + term: >- + Tissue Sample Preservation Method Type + source: caDSR + cde_id: 5432521 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432521%20and%20ver_nr=1.0" + +primary_diagnosis: + common: + description: >- + Text term used to describe the patient's histologic diagnosis, as described + by the World Health Organization's (WHO) International Classification of Diseases + for Oncology (ICD-O). + termDef: + term: >- + ICD-O Primary Disease Diagnosis Type + source: caDSR + cde_id: 6161032 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161032%20and%20ver_nr=1.0" + +primary_disease: + common: + description: >- + Indicates whether the specific diagnosis represents the disease that was the + primary focus of the study. + termDef: + term: >- + Primary Disease + source: + cde_id: + cde_version: + term_url: + +primary_gleason_grade: + common: + description: >- + The text term used to describe the primary Gleason score, which describes the + pattern of cells making up the largest area of the tumor. The primary and secondary + Gleason pattern grades are combined to determine the patient's Gleason grade + group, which is used to determine the aggresiveness of prostate cancer. Note + that this grade describes the entire prostatectomy specimen and is not specific + to the sample used for sequencing. + termDef: + term: >- + Gleason Primary Score For Prostate Cancer Category + source: caDSR + cde_id: 5936800 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5936800%20and%20ver_nr=1.0" + +primary_site: + common: + description: >- + The text term used to describe the primary site of disease, as categorized by + the World Health Organization's (WHO) International Classification of Diseases + for Oncology (ICD-O). This categorization groups cases into general categories. + Reference tissue_or_organ_of_origin on the diagnosis node for more specific + primary sites of disease. + termDef: + term: >- + ICD-O Primary Anatomic Site Category + source: caDSR + cde_id: 6161019 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161019%20and%20ver_nr=1.0" + +prior_malignancy: + common: + description: >- + The yes/no/unknown indicator used to describe the patient's history of prior + cancer diagnosis. + termDef: + term: >- + Prior Cancer Diagnosis Occurrence Description Text + source: caDSR + cde_id: 3382736 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3382736%20and%20ver_nr=2.0" + +prior_treatment: + common: + description: >- + A yes/no/unknown/not applicable indicator related to the administration of therapeutic + agents received before the body specimen was collected. + termDef: + term: >- + Therapeutic Procedure Prior Specimen Collection Administered Yes No Unknown + Not Applicable Indicator + source: caDSR + cde_id: 4231463 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4231463%20and%20ver_nr=1.0" + +proc_internal: + common: + description: >- + Internal data processing flag + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +procedures_performed: + common: + description: >- + The type of procedures performed on the patient. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +progression_or_recurrence: + common: + description: >- + Indicates whether a patient has a progression or recurrence after initial treatment. + This can include local, regional, or metastatic disease. + termDef: + term: >- + New Neoplasm Event Post Initial Therapy Indicator + source: caDSR + cde_id: 3121376 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3121376%20and%20ver_nr=1.0" + +progression_or_recurrence_anatomic_site: + common: + description: >- + The text term used to describe the anatomic site of the progressive or recurrent + disease. + termDef: + term: >- + Progression or Recurrence Anatomic Site Category + source: caDSR + cde_id: 6161026 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161026%20and%20ver_nr=1.0" + +progression_or_recurrence_type: + common: + description: >- + The text term used to describe the type of progressive or recurrent disease + or relapsed disease. + termDef: + term: >- + Progression or Recurrence Description Type + source: caDSR + cde_id: 6142385 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142385%20and%20ver_nr=1.0" + +project_id: + common: + description: >- + Unique ID for any specific defined piece of work that is undertaken or attempted + to meet a single requirement. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +proportion_base_mismatch: + common: + description: >- + Proportion of mismatched bases collected from samtools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +proportion_coverage_10x: + common: + description: >- + Proportion of all reference bases for whole genome sequencing, or targeted bases + for whole exome and targeted sequencing, that achieves 10X or greater coverage + from Picard Tools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +proportion_coverage_30x: + common: + description: >- + Proportion of all reference bases for whole genome sequencing, or targeted bases + for whole exome and targeted sequencing, that achieves 30X or greater coverage + from Picard Tools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +proportion_reads_duplicated: + common: + description: >- + Proportion of duplicated reads collected from samtools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +proportion_reads_mapped: + common: + description: >- + Proportion of mapped reads collected from samtools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +proportion_targets_no_coverage: + common: + description: >- + Proportion of targets that did not reach 1X coverage over any base from Picard + Tools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +prostatic_chips_positive_count: + common: + description: >- + The text term used to describe the number of positive prostatic chips, which + are generated from transurethral resection of the prostate (TURP) procedures + and are generally used for relieving urinary obstruction due to nodular hyperplasia + of the prostate (benign prostatic hyperplasia). + termDef: + term: >- + Prostate Chips Positive Count + source: + cde_id: + cde_version: + term_url: + +prostatic_chips_total_count: + common: + description: >- + The text term used to describe the total number of prostatic chips, which are + generated from transurethral resection of the prostate (TURP) procedures and + are generally used for relieving urinary obstruction due to nodular hyperplasia + of the prostate (benign prostatic hyperplasia). + termDef: + term: >- + Prostate Chips Total Count + source: + cde_id: + cde_version: + term_url: + +prostatic_involvement_percent: + common: + description: >- + Numeric value that represents the percentage of prostatic involvement found + in a specific tissue sample. + termDef: + term: >- + Specimen Prostatic Involvement Percentage Value + source: + cde_id: + cde_version: + term_url: + +protocol_identifier: + common: + description: >- + A sequence of letters, numbers, or other characters that uniquely identifies + a study protocol. + termDef: + term: + source: NCIt + cde_id: C132299 + cde_version: 22.05e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132299" + +qc_metric_state: + common: + description: >- + State classification given by FASTQC for the metric. Metric specific details + about the states are available on their website. + termDef: + term: >- + QC Metric State + source: FastQC + cde_id: + cde_version: + term_url: "http://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/3%20Analysis%20Modules/" + +race: + common: + description: >- + An arbitrary classification of a taxonomic group that is a division of a species. + It usually arises as a consequence of geographical isolation within a species + and is characterized by shared heredity, physical attributes and behavior, and + in the case of humans, by common history, nationality, or geographic distribution. + The provided values are based on the categories defined by the U.S. Office of + Management and Business and used by the U.S. Census Bureau. + termDef: + term: >- + Race Category Text + source: caDSR + cde_id: 2192199 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2192199%20and%20ver_nr=1.0" + +radon_exposure: + common: + description: >- + The yes/no/unknown indicator used to describe whether the patient was exposed + to radon. + termDef: + term: >- + Person Lifetime Risk Radon Exposure Indicator + source: caDSR + cde_id: 2816352 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2816352%20and%20ver_nr=1.0" + +read_group_name: + common: + description: >- + The name of the read group. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +read_length: + common: + description: >- + The length of the reads. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +read_pair_number: + common: + description: >- + Denotes whether a submitted FASTQ file contains forward (R1) or reverse (R2) + reads for paired-end sequencing. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +reason_treatment_ended: + common: + description: >- + The text term used to describe the reason a specific treatment or regimen ended. + termDef: + term: >- + Treatment Ended Reason + source: + cde_id: + cde_version: + term_url: + +recist_targeted_regions_number: + common: + description: >- + Numeric value that represents the number of baseline target lesions, as described + by the Response Evaluation Criteria in Solid Tumours (RECIST) criteria. + termDef: + term: >- + RECIST Targeted Regions Value + source: + cde_id: + cde_version: + term_url: + +recist_targeted_regions_sum: + common: + description: >- + Numeric value that represents the sum of baseline target lesions, as described + by the Response Evaluation Criteria in Solid Tumours (RECIST) criteria. + termDef: + term: >- + RECIST Targeted Regions Sum + source: + cde_id: + cde_version: + term_url: + +reflux_treatment_type: + common: + description: >- + Text term used to describe the types of treatment used to manage gastroesophageal + reflux disease (GERD). + termDef: + term: >- + Gastroesophageal Reflux Disease Treatment Type + source: caDSR + cde_id: 3440206 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3440206%20and%20ver_nr=1.0" + +regimen_or_line_of_therapy: + common: + description: >- + The text term used to describe the regimen or line of therapy. + termDef: + term: >- + Regimen or Line of Therapy Text + source: caDSR + cde_id: 6161024 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161024%20and%20ver_nr=1.0" + +relationship_age_at_diagnosis: + common: + description: >- + The age (in years) when the patient's relative was first diagnosed. + termDef: + term: >- + Relative Diagnosis Age Value + source: caDSR + cde_id: 5300571 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5300571%20and%20ver_nr=1.0" + +relationship_gender: + common: + description: >- + The text term used to describe the gender of the patient's relative with a history + of cancer. + termDef: + term: >- + Relative Gender Type + source: caDSR + cde_id: 6161021 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161021%20and%20ver_nr=1.0" + +relationship_primary_diagnosis: + common: + description: >- + The text term used to describe the malignant diagnosis of the patient's relative + with a history of cancer. + termDef: + term: >- + Relative Malignant Diagnosis Name + source: caDSR + cde_id: 6161022 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161022%20and%20ver_nr=1.0" + +relationship_type: + common: + description: >- + The subgroup that describes the state of connectedness between members of the + unit of society organized around kinship ties. + termDef: + term: >- + Family Member Relationship Type + source: caDSR + cde_id: 2690165 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2690165%20and%20ver_nr=2.0" + +relative_with_cancer_history: + common: + description: >- + The yes/no/unknown indicator used to describe whether any of the patient's relatives + have a history of cancer. + termDef: + term: >- + Relative Malignant Diagnosis Indicator + source: caDSR + cde_id: 6161023 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161023%20and%20ver_nr=1.0" + +relatives_with_cancer_history_count: + common: + description: >- + The number of relatives the patient has with a known history of cancer. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +residual_disease: + common: + description: >- + Tumor cells that remain in the body following cancer treatment. + termDef: + term: >- + Surgical Margin Resection Status + source: NCIt + cde_id: C4809 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4809" + +residual_tumor: + common: + description: >- + Tumor cells that remain in the body following cancer treatment. + termDef: + term: >- + Residual Disease + source: NCIt + cde_id: C4809 + cde_version: 21.04d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4809" + +residual_tumor_measurement: + common: + description: >- + A measurement of the tumor cells that remain in the body following cancer treatment. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +respirable_crystalline_silica_exposure: + common: + description: >- + The yes/no/unknown indicator used to describe whether a patient was exposed + to respirable crystalline silica, a widespread, naturally occurring, crystalline + metal oxide that consists of different forms including quartz, cristobalite, + tridymite, tripoli, ganister, chert, and novaculite. + termDef: + term: >- + Person Respirable Cystalline Silica Exposure Indicator + source: caDSR + cde_id: + cde_version: + term_url: + +rhabdoid_percent: + common: + description: >- + Numeric value that represents the percentage of rhabdoid features found in a + specific tissue sample. + termDef: + term: >- + Specimen Rhabdoid Features Percentage Value + source: caDSR + cde_id: 6790120 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6790120%20and%20ver_nr=1.0" + +rhabdoid_present: + common: + description: >- + Indicator describing whether rhabdoid features were present. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +ribosomal_rna_28s_16s_ratio: + common: + description: >- + The 28S/18S ribosomal RNA band ratio used to assess the quality of total RNA. + termDef: + term: >- + 28s/18s Ribosomal RNA Ratio + source: + cde_id: + cde_version: + term_url: + +rin: + common: + description: >- + A numerical assessment of the integrity of RNA based on the entire electrophoretic + trace of the RNA sample including the presence or absence of degradation products. + termDef: + term: >- + Biospecimen RNA Integrity Number Value + source: caDSR + cde_id: 5278775 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5278775%20and%20ver_nr=1.0" + +risk_factor: + common: + description: >- + The text term used to describe a risk factor the patient had at the time of + or prior to their diagnosis. + termDef: + term: >- + Risk Factor Description Type + source: caDSR + cde_id: 6142389 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142389%20and%20ver_nr=1.0" + +risk_factors: + common: + description: >- + The text term used to describe a risk factor the patient had at the time of + or prior to their diagnosis. + termDef: + term: >- + Risk Factor Description Type + source: caDSR + cde_id: 6142389 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142389%20and%20ver_nr=1.0" + +risk_factor_method_of_diagnosis: + common: + description: >- + The clinical or laboratory procedure(s) used in the determination of a diagnosis + described in this context as a risk factor. + termDef: + term: >- + Diagnostic Method + source: NCIt + cde_id: C177576 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C177576" + +risk_factor_treatment: + common: + description: >- + The yes/no/unknown indicator used to describe whether the patient received treatment + for a risk factor the patient had at the time of or prior to their diagnosis. + termDef: + term: >- + Risk Factor Treatment Indicator + source: caDSR + cde_id: 6514356 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6514356%20and%20ver_nr=1.0" + +rna_integrity_number: + common: + description: >- + A numerical assessment of the integrity of RNA based on the entire electrophoretic + trace of the RNA sample, including the presence or absence of degradation products. + termDef: + term: >- + RNA Integrity Number + source: NCIt + cde_id: C63637 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63637" + term_id: C63637 + term_version: 20.10d + +route_of_administration: + common: + description: >- + The pathway by which a substance is administered in order to reach the site + of action in the body. + termDef: + term: >- + Route of Administration + source: NCIt + cde_id: C38114 + cde_version: 21.04d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38114" + +sample_ordinal: + common: + description: >- + A number describing the samples place in an ordered sequence. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +sample_type: + common: + description: >- + Text term to describe the source of a biospecimen used for a laboratory test. + termDef: + term: >- + Specimen Type Collection Biospecimen Type + source: caDSR + cde_id: 3111302 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3111302%20and%20ver_nr=2.0" + +sample_type_id: + common: + description: >- + The accompanying sample type id for the sample type. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +sarcomatoid_percent: + common: + description: >- + Numeric value that represents the percentage of sarcomatoid features found in + a specific tissue sample. + termDef: + term: >- + Specimen Sarcomatoid Features Percentage Value + source: caDSR + cde_id: 2429786 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2429786%20and%20ver_nr=1.0" + +sarcomatoid_present: + common: + description: >- + Indicator describing whether sarcomatoid features were present. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +satellite_nodule_present: + common: + description: >- + Indicator noting whether a nodule or tumor is located within a small distance + (e.g. 2cm) of the primary tumor. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +scan_tracer_used: + common: + description: >- + The text term used to describe the type of tracer used during the imaging or + scan of the patient. + termDef: + term: >- + Imaging Tracer Used + source: + cde_id: + cde_version: + term_url: + +second_exon: + common: + description: >- + The second exon number involved in molecular variation. If a specific genetic + variant is being reported, this property can be used to capture the second exon + where that variant is located. This property is typically used for a translocation + where two different locations are involved in the variation. + termDef: + term: >- + Molecular Laboratory Procedure Exon Identification Number + source: caDSR + cde_id: + cde_version: + term_url: + +second_gene_symbol: + common: + description: >- + The text term used to describe a secondary gene targeted or included in molecular + analysis. For rearrangements, this should represent the location of the variant. + termDef: + term: >- + Molecular Analysis Secondary Gene Symbol Code + source: caDSR + cde_id: 6142393 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142393%20and%20ver_nr=1.0" + +secondary_gleason_grade: + common: + description: >- + The text term used to describe the secondary Gleason score, which describes + the pattern of cells making up the second largest area of the tumor. The primary + and secondary Gleason pattern grades are combined to determine the patient's + Gleason grade group, which is used to determine the aggresiveness of prostate + cancer. Note that this grade describes the entire prostatectomy specimen and + is not specific to the sample used for sequencing. + termDef: + term: >- + Gleason Secondary Score For Prostate Cancer Category + source: caDSR + cde_id: 5936802 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5936802%20and%20ver_nr=1.0" + +secondhand_smoke_as_child: + common: + description: >- + The text term used to indicate whether the patient was exposed to secondhand + smoke as a child. + termDef: + term: >- + Smoking History Secondhand Smoke Exposure Indicator + source: caDSR + cde_id: 6841888 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6841888%20and%20ver_nr=1.0" + +section_location: + common: + description: >- + Tissue source of the slide. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +selected_normal_low_pass_wgs: + common: + description: >- + Denotes which low-pass WGS normal aliquot the submitter prefers to use for variant + calling. Only one normal per experimental strategy per case can be selected. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +selected_normal_targeted_sequencing: + common: + description: >- + Denotes which targeted_sequencing normal aliquot the submitter prefers to use + for variant calling. Only one normal per experimental strategy per case can + be selected. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +selected_normal_wgs: + common: + description: >- + Denotes which WGS normal aliquot the submitter prefers to use for variant calling. + Only one normal per experimental strategy per case can be selected. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +selected_normal_wxs: + common: + description: >- + Denotes which WXS normal aliquot the submitter prefers to use for variant calling. + Only one normal per experimental strategy per case can be selected. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +sequencing_center: + common: + description: >- + Name of the center that provided the sequence files. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +shortest_dimension: + common: + description: >- + Numeric value that represents the shortest dimension of the sample, measured + in millimeters. + termDef: + term: >- + Tissue Sample Short Dimension Millimeter Measurement + source: caDSR + cde_id: 5432603 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432603%20and%20ver_nr=1.0" + +single_cell_library: + common: + description: >- + Library preparation strategy that distinguishes different single-cell assays. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +site_of_resection_or_biopsy: + common: + description: >- + The text term used to describe the anatomic site of origin, of the patient's + malignant disease, as described by the World Health Organization's (WHO) International + Classification of Diseases for Oncology (ICD-O). + termDef: + term: >- + ICD-O Origin of Disease Anatomic Site + source: caDSR + cde_id: 6161034 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161034%20and%20ver_nr=1.0" + +sites_of_involvement: + common: + description: >- + The anatomic sites of disease involvement in addition to the primary anatomic + site. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +sites_of_involvement_count: + common: + description: >- + The number of anatomic sites of disease. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +size_extraocular_nodule: + common: + description: >- + The size of the nodule that is outside the eye. + termDef: + term: >- + Extraocular Nodule Size + source: NCIt + cde_id: C185261 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C185261" + term_id: C185261 + term_version: 24.07e + +size_selection_range: + common: + description: >- + Range of size selection. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +smokeless_tobacco_quit_age: + common: + description: >- + The age the subject quit smoking tobacco. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +smoking_frequency: + common: + description: >- + The text term used to generally describe how often the patient smokes. + termDef: + term: >- + Person Smoking Frequency + source: caDSR + cde_id: + cde_version: + term_url: + +source_center: + common: + description: >- + Name of the center that provided the item. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +specialized_molecular_test: + common: + description: >- + Text term used to describe a specific test that is not covered in the list of + molecular analysis methods. + termDef: + term: >- + Molecular Laboratory Procedure Specialized Text + source: caDSR + cde_id: 6142526 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142526%20and%20ver_nr=1.0" + +specimen_type: + common: + description: >- + The type of a material sample taken from a biological entity for testing, diagnostic, + propagation, treatment or research purposes. This includes particular types + of cellular molecules, cells, tissues, organs, body fluids, embryos, and body + excretory substances. + termDef: + term: >- + Biospecimen Type + source: NCIt + cde_id: C70713 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70713" + +spectrophotometer_method: + common: + description: >- + Name of the method used to determine the concentration of purified nucleic acid + within a solution. + termDef: + term: >- + Purification Nucleic Acid Solution Concentration Determination Method Type + source: caDSR + cde_id: 3008378 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3008378%20and%20ver_nr=1.0" + +spike_ins_concentration: + common: + description: >- + Spike in concentration. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +spike_ins_fasta: + common: + description: >- + Name of the FASTA file that contains the spike-in sequences. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +stain_type: + common: + description: >- + The text term used to describe the type of stain used on a slide. + termDef: + term: >- + Tissue Slide Stain Type + source: + cde_id: + cde_version: + term_url: + +state: + common: + description: >- + The current state of the object. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +supratentorial_localization: + common: + description: >- + Text term to specify the location of the supratentorial tumor. + termDef: + term: >- + Tumor Location Central Nervous System Tissue Type + source: caDSR + cde_id: 3133891 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3133891%20and%20ver_nr=1.0" + +synchronous_malignancy: + common: + description: >- + A yes/no/unknown indicator used to describe whether the patient had an additional + malignant diagnosis at the same time the tumor used for sequencing was diagnosed. + If both tumors were sequenced, both tumors would have synchronous malignancies. + termDef: + term: >- + Malignant Disease Diagnosis Synchronous Indicator + source: caDSR + cde_id: 6142390 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142390%20and%20ver_nr=1.0" + +target_capture_kit: + common: + description: >- + Description that can uniquely identify a target capture kit. Suggested value + is a combination of vendor, kit name, and kit version. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +target_capture_kit_catalog_number: + common: + description: >- + Catalog of Target Capture Kit. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +target_capture_kit_name: + common: + description: >- + Name of Target Capture Kit. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +target_capture_kit_target_region: + common: + description: >- + Target Capture Kit BED file. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +target_capture_kit_vendor: + common: + description: >- + Vendor of Target Capture Kit. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +target_capture_kit_version: + common: + description: >- + Version of Target Capture Kit. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +test_analyte_type: + common: + description: >- + The text term used to describe the type of analyte used for molecular testing. + termDef: + term: >- + Molecular Laboratory Procedure Analyte Type + source: caDSR + cde_id: 6142394 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142394%20and%20ver_nr=1.0" + +test_result: + common: + description: >- + The text term used to describe the result of the molecular test. If the test + result was a numeric value see test_value. + termDef: + term: >- + Molecular Laboratory Procedure Outcome + source: caDSR + cde_id: 6142397 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142397%20and%20ver_nr=1.0" + +test_units: + common: + description: >- + The text term used to describe the units of the test value for a molecular test. + This property is used in conjunction with test_value. + termDef: + term: >- + Molecular Laboratory Procedure Outcome Unit of Measure + source: caDSR + cde_id: 6142525 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142525%20and%20ver_nr=1.0" + +test_value: + common: + description: >- + The text term or numeric value used to describe a specific result of a molecular + test. + termDef: + term: >- + Molecular Laboratory Procedure Outcome Text + source: caDSR + cde_id: 6142524 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142524%20and%20ver_nr=1.0" + +test_value_range: + common: + description: >- + The range of values within which the subject's results fall. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +therapeutic_agents: + common: + description: >- + Text identification of the individual agent(s) used as part of a treatment regimen. + termDef: + term: >- + Prior Therapy Regimen Text + source: caDSR + cde_id: 2975232 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2975232%20and%20ver_nr=1.0" + +therapeutic_level_achieved: + common: + description: >- + Indicates a target level of treatment was reached, according to the patient's + treatment plan. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +therapeutic_target_level: + common: + description: >- + Describes a specific target for an administered treatment. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +time_between_clamping_and_freezing: + common: + description: >- + Numeric representation of the elapsed time between the surgical clamping of + blood supply and freezing of the sample, measured in minutes. + termDef: + term: >- + Tissue Sample Clamping and Freezing Elapsed Minute Time + source: caDSR + cde_id: 5432611 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432611%20and%20ver_nr=1.0" + +time_between_excision_and_freezing: + common: + description: >- + Numeric representation of the elapsed time between the excision and freezing + of the sample, measured in minutes. + termDef: + term: >- + Tissue Sample Excision and Freezing Elapsed Minute Time + source: caDSR + cde_id: 5432612 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432612%20and%20ver_nr=1.0" + +time_between_waking_and_first_smoke: + common: + description: >- + The text term used to describe the approximate amount of time elapsed between + the time the patient wakes up in the morning to the time they smoke their first + cigarette. + termDef: + term: >- + Person Smoking Frequency + source: caDSR + cde_id: 3279220 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3279220%20and%20ver_nr=1.0" + +timepoint_category: + common: + description: >- + Category describing a specific point in the time continuum, including those + established relative to an event. + termDef: + term: >- + Timepoint + source: NCIt + cde_id: C68568 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68568" + +tissue_collection_type: + common: + description: >- + The text term used to describe the type of collection used to obtain tissue. + termDef: + term: >- + Tissue Collection Type + source: + cde_id: + cde_version: + term_url: + +tissue_microarray_coordinates: + common: + description: >- + The alphanumeric term used to describe the coordinates of a specific tissue + located on a tissue microarray slide. + termDef: + term: >- + Tissue Microarray Coordinates Value + source: + cde_id: + cde_version: + term_url: + +tissue_or_organ_of_origin: + common: + description: >- + The text term used to describe the anatomic site of origin, of the patient's + malignant disease, as described by the World Health Organization's (WHO) International + Classification of Diseases for Oncology (ICD-O). + termDef: + term: >- + ICD-O Origin of Disease Anatomic Site + source: caDSR + cde_id: 6161035 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6161035%20and%20ver_nr=1.0" + +tissue_type: + common: + description: >- + Text term that represents a description of the kind of tissue collected with + respect to disease status or proximity to tumor tissue. + termDef: + term: >- + Tissue Sample Description Type + source: caDSR + cde_id: 5432687 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432687%20and%20ver_nr=1.0" + +to_trim_adapter_sequence: + common: + description: >- + Does the user suggest adapter trimming? + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tobacco_smoking_onset_year: + common: + description: >- + The year in which the participant began smoking. + termDef: + term: >- + Started Smoking Year + source: caDSR + cde_id: 2228604 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2228604%20and%20ver_nr=1.0" + +tobacco_smoking_quit_year: + common: + description: >- + The year in which the participant quit smoking. + termDef: + term: >- + Stopped Smoking Year + source: caDSR + cde_id: 2228610 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2228610%20and%20ver_nr=1.0" + +tobacco_smoking_status: + common: + description: >- + Category describing current smoking status and smoking history as self-reported + by a patient. + termDef: + term: >- + Patient Smoking History Category + source: caDSR + cde_id: 2181650 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2181650%20and%20ver_nr=1.0" + +tobacco_use_per_day: + common: + description: >- + Numeric value that represents the number of times the patient uses tobacco each + day. + termDef: + term: >- + Daily Tobacco Use Count + source: + cde_id: + cde_version: + term_url: + +total_reads: + common: + description: >- + Total number of reads collected from samtools. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +total_sequences: + common: + description: >- + The total number of nucleotide sequences processed. + termDef: + term: >- + Total Number of Nucleotide Sequences Processed + source: NCIt + cde_id: C181855 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C181855" + term_id: C181855 + term_version: 23.11d + +transcript: + common: + description: >- + Alphanumeric value used to describe the transcript of a specific genetic variant. + termDef: + term: >- + Molecular Laboratory Procedure Transcript Location Text + source: caDSR + cde_id: 6142465 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142465%20and%20ver_nr=1.0" + +transglottic_extension: + common: + description: >- + The text term used to describe an extension of the tumor beyond the opening + into the ventricles and vocal cords. + termDef: + term: >- + Transglottic Extension + source: NCIt + cde_id: C160996 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C160996" + term_id: C160996 + term_version: 19.12e + +treatment_anatomic_site: + common: + description: >- + The anatomic site or field targeted by a treatment regimen or single agent therapy. + termDef: + term: >- + Treatment Anatomic Site + source: caDSR + cde_id: 5615611 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5615611%20and%20ver_nr=1.0" + +treatment_arm: + common: + description: >- + Text term used to describe the treatment arm assigned to a patient at the time + eligibility is determined. + termDef: + term: >- + Protocol Treatment Arm Text + source: caDSR + cde_id: 7068995 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=7068995%20and%20ver_nr=1.0" + +treatment_dose: + common: + description: >- + The numeric value used to describe the total dose of an agent the patient received. + termDef: + term: >- + Agent Dose + source: caDSR + cde_id: 2182728 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2182728%20and%20ver_nr=3.0" + +treatment_dose_max: + common: + description: >- + A maximum quantity of an agent administered to the study participant. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +treatment_dose_units: + common: + description: >- + The text term used to describe the dose units of an agent the patient received. + termDef: + term: >- + Agent Dose Units + source: + cde_id: + cde_version: + term_url: + +treatment_duration: + common: + description: >- + The number of days during which the treatment was given. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +treatment_effect: + common: + description: >- + The text term used to describe the pathologic effect a treatment(s) had on the + tumor. + termDef: + term: >- + Treatment Effect Type + source: caDSR + cde_id: 6514354 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6514354%20and%20ver_nr=1.0" + +treatment_effect_indicator: + common: + description: >- + The text term used to indicate whether the treatment had an effect on the patient. + termDef: + term: >- + Treatment Effect Indicator + source: + cde_id: + cde_version: + term_url: + +treatment_frequency: + common: + description: >- + The text term used to describe the frequency the patient received an agent or + regimen. + termDef: + term: >- + Treatment Frequency + source: + cde_id: + cde_version: + term_url: + +treatment_intent_type: + common: + description: >- + Text term to identify the reason for the administration of a treatment regimen. + [Manually-curated] + termDef: + term: >- + Treatment Regimen Intent Type + source: caDSR + cde_id: 2793511 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2793511%20and%20ver_nr=1.0" + +treatment_or_therapy: + common: + description: >- + A yes/no/unknown/not applicable indicator related to the administration of therapeutic + agents received. + termDef: + term: >- + Therapeutic Procedure Prior Specimen Collection Administered Yes No Unknown + Not Applicable Indicator + source: caDSR + cde_id: 4231463 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4231463%20and%20ver_nr=1.0" + +treatment_outcome: + common: + description: >- + Text term that describes the patient's final outcome after the treatment was + administered. + termDef: + term: >- + Treatment Outcome Type + source: caDSR + cde_id: 5102383 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5102383%20and%20ver_nr=1.0" + +treatment_outcome_duration: + common: + description: >- + The number of days a patient reached a specific result or effect after treatment. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +treatment_type: + common: + description: >- + Text term that describes the kind of treatment administered. + termDef: + term: >- + Treatment Method Type + source: caDSR + cde_id: 5102381 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5102381%20and%20ver_nr=1.0" + +tumor_code: + common: + description: >- + Diagnostic tumor code of the tissue sample source. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tumor_code_id: + common: + description: >- + BCR-defined id code for the tumor sample. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tumor_confined_to_organ_of_origin: + common: + description: >- + The yes/no/unknown indicator used to describe whether the tumor is confined + to the organ where it originated and did not spread to a proximal or distant + location within the body. + termDef: + term: >- + Tumor Mass Organ Origin Yes No Unknown Not Applicable Indicator + source: caDSR + cde_id: 4925494 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4925494%20and%20ver_nr=1.0" + +tumor_depth: + common: + description: >- + Numeric value that represents the depth of tumor invasion, measured in millimeters + (mm). + termDef: + term: >- + Depth of Tumor Measurement + source: + cde_id: + cde_version: + term_url: + +tumor_descriptor: + common: + description: >- + Text that describes the kind of disease present in the tumor specimen as related + to a specific timepoint. + termDef: + term: >- + Tumor Tissue Disease Description Type + source: caDSR + cde_id: 3288124 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3288124%20and%20ver_nr=1.0" + +tumor_focality: + common: + description: >- + The text term used to describe whether the patient's disease originated in a + single location or multiple locations. + termDef: + term: >- + Primary Neoplasm Focus Type + source: caDSR + cde_id: 3174022 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3174022%20and%20ver_nr=1.0" + +tumor_grade: + common: + description: >- + Numeric value to express the degree of abnormality of cancer cells, a measure + of differentiation and aggressiveness. + termDef: + term: >- + Neoplasm Histologic Grade + source: caDSR + cde_id: 2785839 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2785839%20and%20ver_nr=2.0" + +tumor_grade_category: + common: + description: >- + Describes the number of levels or 'tiers' in the system used to determine the + degree of tumor differentiation. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tumor_largest_dimension_diameter: + common: + description: >- + Numeric value used to describe the maximum diameter or dimension of the primary + tumor, measured in centimeters. + termDef: + term: >- + Tumor Largest Dimension Measurement + source: caDSR + cde_id: 64215 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=64215%20and%20ver_nr=3.0" + +tumor_level_prostate: + common: + description: >- + The level(s) of the prostate from which the tumor originated. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tumor_ploidy: + common: + description: >- + Numeric value used to describe the number of sets of chromosomes in a cell or + an organism. For example, haploid means one set and diploid means two sets. + termDef: + term: >- + Tumor Ploidy Value + source: + cde_id: + cde_version: + term_url: + +tumor_purity: + common: + description: >- + Numeric value used to describe the ratio of tumor cells compared to total cells + present in a sample. + termDef: + term: >- + Tumor Purity Ratio + source: + cde_id: + cde_version: + term_url: + +tumor_regression_grade: + common: + description: >- + A numeric value used to measure therapeutic response of the primary tumor and + predict patient outcomes based on a three-point tumor regression grading system. + termDef: + term: >- + Modified Ryan Scheme for Tumor Regression Score 3 Point Scale + source: caDSR + cde_id: 6471217 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6471217%20and%20ver_nr=1.0" + +tumor_thickness: + common: + description: >- + A measurement of the thickness of a sectioned slice (of tissue or mineral or + other substance) in millimeters (mm). + termDef: + term: >- + Section Thickness + source: NCIt + cde_id: C176286 + cde_version: 21.04d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C176286" + +type_of_smoke_exposure: + common: + description: >- + The text term used to describe the patient's specific type of smoke exposure. + termDef: + term: >- + Person Smoke Exposure Type + source: caDSR + cde_id: + cde_version: + term_url: + +type_of_tobacco_used: + common: + description: >- + The text term used to describe the specific type of tobacco used by the patient. + termDef: + term: >- + Person Tobacco Use Type + source: caDSR + cde_id: + cde_version: + term_url: + +uicc_clinical_m: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The clinical M category describes the presence or otherwise of distant + metastatic spread as determined during a clinical exam. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uicc_clinical_n: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The clinical N category describes the regional lymph node involvement + as determined during a clinical exam. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uicc_clinical_stage: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The clinical stage is based on the T, N, and M categories which + are determined during a clinical exam. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uicc_clinical_t: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The clinical T category describes the primary tumor site and size + as determined during a clinical exam. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uicc_pathologic_m: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The pathological M category describes the presence or otherwise + of distant metastatic spread as determined during a pathology review. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uicc_pathologic_n: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The pathological N category describes the regional lymph node involvement + as determined during a pathology review. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uicc_pathologic_stage: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The pathological stage is based on the T, N, and M categories which + are determined during a pathological review. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uicc_pathologic_t: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The pathological T category describes the primary tumor site and + size as determined during a pathology review. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uicc_staging_system_edition: + common: + description: >- + The UICC TNM Classification is an anatomically based system that records the + primary and regional nodal extent of the tumor and the absence or presence of + metastases. The staging edition describes the specific UICC edition used when + a patient's stage was determined. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +undescended_testis_corrected: + common: + description: >- + Indicates whether the patient's undescended testis was corrected. + termDef: + term: >- + Undescended Testis Corrected + source: + cde_id: + cde_version: + term_url: + +undescended_testis_corrected_age: + common: + description: >- + The patient's age when their undescended testis was corrected. + termDef: + term: >- + Undescended Testis Corrected Age + source: NCIt + cde_id: C181721 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C181721" + term_id: C181721 + term_version: 24.07e + +undescended_testis_corrected_laterality: + common: + description: >- + Describes the lateral location of the patient's undescended testis correction. + termDef: + term: >- + Undescended Testis Corrected Laterality + source: + cde_id: + cde_version: + term_url: + +undescended_testis_corrected_method: + common: + description: >- + Describes the method used to correct the patient's undescended testis. + termDef: + term: >- + Undescended Testis Corrected Method + source: + cde_id: + cde_version: + term_url: + +undescended_testis_history: + common: + description: >- + The persistent failure of one or both testes to descend into the scrotum. + termDef: + term: >- + Undescended Testes + source: NCIt + cde_id: C12326 + cde_version: 21.04d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12326" + +undescended_testis_history_laterality: + common: + description: >- + Describes the lateral location of the patient's undescended testis. + termDef: + term: >- + Undescended Testis Laterality + source: + cde_id: + cde_version: + term_url: + +use_per_day: + common: + description: >- + The average number of times the patient used per day. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +uuid: + common: + description: >- + A 128-bit identifier. Depending on the mechanism used to generate it, it is + either guaranteed to be different from all other UUIDs/GUIDs generated until + 3400 AD or extremely likely to be different. Its relatively small size lends + itself well to sorting, ordering, and hashing of all sorts, storing in databases, + simple allocation, and ease of programming in general. + termDef: + term: >- + Universally Unique Identifier + source: NCIt + cde_id: C54100 + cde_version: + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=16.02d&ns=NCI_Thesaurus&code=C54100" + +variant_origin: + common: + description: >- + The text term used to describe the biological origin of a specific genetic variant. + termDef: + term: >- + Genetic Variation Origin Type + source: caDSR + cde_id: + cde_version: + term_url: + +variant_type: + common: + description: >- + The text term used to describe the type of genetic variation. + termDef: + term: >- + Molecular Laboratory Procedure Genetic Variant Type + source: caDSR + cde_id: 6142402 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142402%20and%20ver_nr=1.0" + +vascular_invasion_present: + common: + description: >- + The yes/no indicator to ask if large vessel or venous invasion was detected + by surgery or presence in a tumor specimen. + termDef: + term: >- + Tumor Vascular Invasion Ind-3 + source: caDSR + cde_id: 64358 + cde_version: 3.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=64358%20and%20ver_nr=3.0" + +vascular_invasion_type: + common: + description: >- + Text term that represents the type of vascular tumor invasion. + termDef: + term: >- + Vascular Tumor Cell Invasion Type + source: caDSR + cde_id: 3168001 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3168001%20and%20ver_nr=1.0" + +viral_hepatitis_serologies: + common: + description: >- + Text term that describes the kind of serological laboratory test used to determine + the patient's hepatitis status. + termDef: + term: >- + Viral Hepatitis Laboratory Procedure Serology Test Method Type + source: caDSR + cde_id: 4395982 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4395982%20and%20ver_nr=1.0" + +vital_status: + common: + description: >- + The survival state of the person registered on the protocol. + termDef: + term: >- + Patient Vital Status + source: caDSR + cde_id: 5 + cde_version: 5.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5%20and%20ver_nr=5.0" + +weeks_gestation_at_birth: + common: + description: >- + Numeric value used to describe the number of weeks starting from the approximate + date of the biological mother's last menstrual period and ending with the birth + of the patient. + termDef: + term: >- + Pregnancy Week Number Count + source: caDSR + cde_id: 2737369 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2737369%20and%20ver_nr=1.0" + +weight: + common: + description: >- + The weight of the patient measured in kilograms. + termDef: + term: >- + Patient Weight Measurement + source: caDSR + cde_id: 651 + cde_version: 4.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=651%20and%20ver_nr=4.0" + +weiss_assessment_findings: + common: + description: >- + Histopathologic criteria to evaluate adrenocortical tumors. + termDef: + term: >- + WEISS Criteria + source: NCIt + cde_id: C104015 + cde_version: 22.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104015" + +weiss_assessment_score: + common: + description: >- + The text term used to describe the overall Weiss assessment score, a commonly + used assessment describing the malignancy of adrenocortical tumors. The Weiss + score is determined based on nine histological criteria including the following: + high nuclear grade, mitotic rate greater than five per 50 high power fields + (HPF), atypical mitotic figures, eosinophilic tumor cell cytoplasm (greater + than 75% tumor cells), diffuse architecture (greater than 33% of tumor), necrosis, + venous invasion, sinusoidal invasion, and capsular invasion. + termDef: + term: >- + Weiss System Category Assessment Total Score + source: caDSR + cde_id: 3648744 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3648744%20and%20ver_nr=1.0" + +well_number: + common: + description: >- + Numeric value that represents the well location within a plate for the analyte + or aliquot from the sample. + termDef: + term: >- + Biospecimen Analyte or Aliquot Plate Well Number + source: caDSR + cde_id: 5432613 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=5432613%20and%20ver_nr=1.0" + +who_cns_grade: + common: + description: >- + The WHO (World Health Organization) grading classification of CNS tumors, which + is based on histological characteristics such as cellularity, mitotic activity, + pleomorphism, necrosis, and endothelial proliferation (neoangiogenesis). + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +who_nte_grade: + common: + description: >- + The WHO (World Health Organization) grading classification of Neuroendocrine + Tumors. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +wilms_tumor_histologic_subtype: + common: + description: >- + The text term used to describe the classification of Wilms tumors distinguishing + between favorable and unfavorable histologic groups. + termDef: + term: >- + Disease Histology Confirmation Favorable Status + source: caDSR + cde_id: 4358735 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=4358735%20and%20ver_nr=1.0" + +workflow_type: + common: + description: >- + The name of the workflow used to process and/or analyze a data set. + termDef: + term: + source: NCIt + cde_id: C181725 + cde_version: 1.0 + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C181725" + term_id: C181725 + term_version: 23.11d + +year_of_birth: + common: + description: >- + Numeric value to represent the calendar year in which an individual was born. + termDef: + term: >- + Year Birth Date Number + source: caDSR + cde_id: 2896954 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2896954%20and%20ver_nr=1.0" + +year_of_death: + common: + description: >- + Numeric value to represent the year of the death of an individual. + termDef: + term: >- + Year Death Number + source: caDSR + cde_id: 2897030 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2897030%20and%20ver_nr=1.0" + +year_of_diagnosis: + common: + description: >- + Numeric value to represent the year of an individual's initial pathologic diagnosis + of cancer. + termDef: + term: >- + Year of initial pathologic diagnosis + source: caDSR + cde_id: 2896960 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=2896960%20and%20ver_nr=1.0" + +year_of_follow_up: + common: + description: >- + The year of the patient's last follow-up appointment or contact. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +years_smoked: + common: + description: >- + Numeric value (or unknown) to represent the number of years a person has been + smoking. + termDef: + term: >- + Person Smoking Duration Year Count + source: caDSR + cde_id: 3137957 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3137957%20and%20ver_nr=1.0" + +zone_of_origin_prostate: + common: + description: >- + The location or position of the tumor by zone of the prostate. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +zygosity: + common: + description: >- + The text term used to describe the zygosity of a specific genetic variant. + termDef: + term: >- + Molecular Laboratory Procedure Genetic Zygosity Type + source: caDSR + cde_id: 6142510 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142510%20and%20ver_nr=1.0" + +ensat_pathologic_stage: + common: + description: >- + An adrenal cancer stage defined according to the European Network for the Study + of Adrenal Tumors (ENSAT) criteria. + termDef: + term: >- + ENSAT Stage + source: NCIt + cde_id: C141099 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C141099" + term_id: C141099 + term_version: 23.03d + +ensat_pathologic_t: + common: + description: >- + A pathologic finding about one or more characteristics of adrenal cancer, following + the rules of the ENSAT staging v7 classification system as they pertain to staging + of the primary tumor. + termDef: + term: >- + Pathologic Primary Tumor ENSAT Staging Finding v7 + source: NCIt + cde_id: C104018 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104018" + term_id: C104018 + term_version: 23.03d + +ensat_pathologic_n: + common: + description: >- + A pathologic finding about one or more characteristics of adrenal cancer, following + the rules of the ENSAT staging v7 classification system as they pertain to staging + of the lymph nodes. + termDef: + term: >- + Pathologic Lymph Nodes ENSAT Staging Finding v7 + source: NCIt + cde_id: C104023 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104023" + term_id: C104023 + term_version: 23.03d + +ensat_clinical_m: + common: + description: >- + A clinical finding about one or more characteristics of adrenal cancer, following + the rules of the ENSAT staging v7 classification system as they pertain to distant + metastases. + termDef: + term: >- + Clinical Distant Metastasis ENSAT Staging Finding v7 + source: NCIt + cde_id: C104027 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104027" + term_id: C104027 + term_version: 23.03d + +discontiguous_lesion_count: + common: + description: >- + The number of the discontiguous lesions in a new tumor event. + termDef: + term: >- + Number of Discontiguous Lesions (New Tumor Event) + source: NCIt + cde_id: C158639 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C158639" + term_id: C158639 + term_version: 23.03d + +tumor_burden: + common: + description: >- + Refers to the number of cancer cells, the size of a tumor, or the amount of + cancer in the body. + termDef: + term: >- + Tumor Burden + source: NCIt + cde_id: C28384 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28384" + term_id: C28384 + term_version: 23.03d + +measurement_unit: + common: + description: >- + The type of unit of measure being used to express a length or distance. + termDef: + term: >- + Unit of Length + source: NCIt + cde_id: C42578 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C42578" + term_id: C42578 + term_version: 23.03d + +clark_level: + common: + description: >- + A morphologic finding indicating the cutaneous melanoma depth of invasion into + the dermis and subcutaneous tissue. + termDef: + term: >- + Clark Level Finding + source: NCIt + cde_id: C94811 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94811" + term_id: C94811 + term_version: 23.03d + +ulceration_indicator: + common: + description: >- + The formation or development of an ulcer. + termDef: + term: >- + Ulceration + source: NCIt + cde_id: C25757 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25757" + term_id: C25757 + term_version: 23.03d + +tumor_infiltrating_lymphocytes: + common: + description: >- + Lymphocytes that show specificity for autologous tumor cells and can infiltrate + a tumor. + termDef: + term: >- + Tumor Infiltrating Lymphocyte + source: NCIt + cde_id: C12546 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12546" + term_id: C12546 + term_version: 23.03d + +tumor_infiltrating_macrophages: + common: + description: >- + Non-neoplastic macrophages that infiltrate a tumor. + termDef: + term: >- + Tumor Infiltrating Macrophages + source: NCIt + cde_id: C111027 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111027" + term_id: C111027 + term_version: 23.03d + +education_level: + common: + description: >- + The years of schooling completed in graded public, private, or parochial schools, + and in colleges, universities, or professional schools. + termDef: + term: >- + Education Level + source: NCIt + cde_id: C17953 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17953" + term_id: C17953 + term_version: 23.03d + +marital_status: + common: + description: >- + A demographic parameter indicating a person's current conjugal status. + termDef: + term: >- + Marital Status + source: NCIt + cde_id: C25188 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25188" + term_id: C25188 + term_version: 23.03d + +relative_deceased: + common: + description: >- + The historical fact that a legal or consanguineous family member has died. + termDef: + term: >- + Deceased Family Member + source: NCIt + cde_id: C81180 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81180" + term_id: C81180 + term_version: 23.03d + +staining_intensity_scale: + common: + description: >- + The scale used by the immunohistochemistry staining rating. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +first_symptom_longest_duration: + common: + description: >- + The length of time the first presenting symptom occurred that related to the + diagnosis of the patient with cancer. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +measurement_type: + common: + description: >- + The method used to measure tumor size. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +contiguous_organ_invaded: + common: + description: >- + The organ or contiguous site the disease migrated to from the primary site. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tumor_depth_measurement: + common: + description: >- + The numerical measurement of tumor depth. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tumor_length_measurement: + common: + description: >- + The numerical measurement of tumor length. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tumor_width_measurement: + common: + description: >- + The numerical measurement of tumor width. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +tumor_depth_descriptor: + common: + description: >- + Text term for the degree to which a tumor has penetrated into organ or tissue. + termDef: + term: >- + Tumor Depth Extent Name + source: caDSR + cde_id: 3808610 + cde_version: 2.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3808610%20and%20ver_nr=2.0" + +melanoma_known_primary: + common: + description: >- + A melanoma which has metastasized from a known primary anatomic site. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +spindle_cell_percent: + common: + description: >- + A quantitative measurement of the percent of spindle-shaped melanocytes compared + to the number of total cells present in a sample. + termDef: + term: >- + Percent of Spindle-Shaped Melanocytes + source: NCIt + cde_id: C200472 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C200472" + term_id: C200472 + term_version: 24.07e + +epithelioid_cell_percent: + common: + description: >- + A quantitative measurement of the percent of epithelioid melanocytes compared + to the number of total cells present in a sample. + termDef: + term: >- + Percent of Epithelioid Melanocytes + source: NCIt + cde_id: C200471 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C200471" + term_id: C200471 + term_version: 24.07e + +tumor_shape: + common: + description: >- + Text term to represent the description of the shape of a tumor determined by + clinical or pathological techniques. + termDef: + term: >- + Tumor Shape Type + source: caDSR + cde_id: 3870445 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3870445%20and%20ver_nr=1.0" + +tumor_measurement_method: + common: + description: >- + The method used to measure tumor size. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +relative_smoker: + common: + description: >- + Indication that a legal or consanguineous family member was a smoker. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +exposure_duration_hrs_per_day: + common: + description: >- + The duration (in hours per day) that a person was exposed. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +country_of_birth: + common: + description: >- + The name of the country in which the patient is born. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +wgs_coverage: + common: + description: >- + Range of coverage values for WGS aligned reads. Each range is non-inclusive + to the lower bound. + termDef: + term: + source: + cde_id: + cde_version: + term_url: + +staining_intensity_value: + common: + description: >- + The degree or magnitude of staining by a dye or reagent within a microscopic + specimen. + termDef: + term: >- + Staining Intensity + source: NCIt + cde_id: C127762 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127762" + term_id: C127762 + term_version: 23.08d + +reason_treatment_not_given: + common: + description: >- + The reason the treatment was not administered. + termDef: + term: >- + Reason Treatment Not Administered + source: NCIt + cde_id: C102704 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102704" + term_id: C102704 + term_version: 23.08d + +myasthenia_gravis_classification: + common: + description: >- + A finding associated with a patient with myasthenia gravis that is based on + the classification system developed by the Myasthenia Gravis Foundation of America + (MGFA) for grading myasthenia gravis that divides the disease into five main + classes and several subclasses. + termDef: + term: >- + Myasthenia Gravis Foundation of America Class + source: NCIt + cde_id: C187352 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C187352" + term_id: C187352 + term_version: 23.08d + +histologic_progression_type: + common: + description: >- + Text term to describe the disease progression as determined by microscopic review + of cells and their surrounding extracellular environment in tissues. + termDef: + term: >- + Histologic Disease Progression Present Type + source: caDSR + cde_id: 3181384 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3181384%20and%20ver_nr=1" + +radiosensitizing_agent: + common: + description: >- + Indication if an agent that makes tumor cells more sensitive to radiation therapy + was used in treatment. + termDef: + term: >- + Radiosensitizing Agent + source: NCIt + cde_id: C798 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C798" + term_id: C798 + term_version: 23.08d + +therapeutic_levels_achieved: + common: + description: >- + An indication that the intended level of therapeutic agent was achieved in an + individual. + termDef: + term: >- + Therapeutic Agent Level Achieved Indicator + source: NCIt + cde_id: C198198 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C198198" + term_id: C198198 + term_version: 23.08d + +oxygen_use_type: + common: + description: >- + Text term to describe the type of oxygen the patient uses at home. + termDef: + term: >- + Patient Oxygen Use Type + source: caDSR + cde_id: 3181408 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3181408%20and%20ver_nr=1" + +oxygen_use_indicator: + common: + description: >- + An indication whether administration of oxygen to an individual occurred. + termDef: + term: >- + Oxygen Therapy Administered Indicator + source: caDSR + cde_id: 7847908 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=7847908%20and%20ver_nr=1" + +extrathyroid_extension: + common: + description: >- + Text term to describe the degree to which the primary tumor has extra thyroid + extension. + termDef: + term: >- + Extrathyroid Carcinoma Present Extension Status + source: caDSR + cde_id: 3179452 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=3179452%20and%20ver_nr=1" + +genome_doubling: + common: + description: >- + Number of genome doubling events. + termDef: + term: >- + Genome Doubling Events + source: NCIt + cde_id: C206453 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206453" + term_id: C206453 + term_version: 24.07e + +cancer_dna_fraction: + common: + description: >- + Fraction of cancer DNA in the tumor tissue. + termDef: + term: >- + Cancer DNA Fraction + source: NCIt + cde_id: C206454 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206454" + term_id: C206454 + term_version: 24.07e + +subclonal_genome_fraction: + common: + description: >- + Fraction of subclonal genome in the tumor tissue. + termDef: + term: >- + Subclonal DNA Fraction + source: NCIt + cde_id: C206455 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206455" + term_id: C206455 + term_version: 24.07e + +curated_model_index: + common: + description: >- + Index number of the curated model. + termDef: + term: >- + Curated Model Index + source: NCIt + cde_id: C206456 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206456" + term_id: C206456 + term_version: 24.07e + +workflow_link: + common: + description: >- + A URL-formatted web address for a data analysis workflow. + termDef: + term: >- + Data Analysis Workflow URL + source: NCIt + cde_id: C182116 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C182116" + term_id: C182116 + term_version: 23.11d + +workflow_version: + common: + description: >- + The version of the workflow used in data analysis. + termDef: + term: >- + Data Analysis Workflow Version + source: NCIt + cde_id: C182117 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C182117" + term_id: C182117 + term_version: 23.11d + +tumor_of_origin: + common: + description: >- + The submitter_id string of the primary diagnosis node. + termDef: + term: >- + Tumor of Origin Diagnosis Node + source: + cde_id: + cde_version: + term_url: + +prescribed_dose_units: + common: + description: >- + The units of the amount of agent or medication formally prescribed to an individual. + termDef: + term: >- + Prescribed Dose Units + source: NCIt + cde_id: C206478 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206478" + term_id: C206478 + term_version: 24.07e + +number_of_pregnancies: + common: + description: >- + A measurement of the total number of pregnancy events experienced by the female + subject. + termDef: + term: >- + Number of Pregnancies + source: NCIt + cde_id: C106551 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106551" + term_id: C106551 + term_version: 23.11d + +prcc_type: + common: + description: >- + The type of papillary renal cell carcinoma. It is classified as type 1 or 2, + based on the cytoplasmic volume and the thickness of the lining neoplastic cells. + termDef: + term: >- + Papillary Renal Cell Carcinoma + source: NCIt + cde_id: C6975 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6975" + term_id: C6975 + term_version: 23.11d + +calgb_risk_group: + common: + description: >- + A classification strategy for Acute Myeloid Leukemia (AML) developed by the + cancer research cooperative group Cancer And Leukemia Group B that assigns a + rating based on the cytogenetic and molecular features of a particular disease. + termDef: + term: >- + Cytogenetic Risk Group-CALGB Criteria for AML + source: NCIt + cde_id: C159229 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C159229" + term_id: C159229 + term_version: 23.11d + +treatment_emergent_adverse_event: + common: + description: >- + A situation that emerges during treatment, having been absent pretreatment, + or worsens relative to the pretreatment state. + termDef: + term: >- + Treatment-Emergent Adverse Event + source: NCIt + cde_id: C142733 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142733" + term_id: C142733 + term_version: 23.11d + +viral_hepatitis_serology_tests: + common: + description: >- + A set of tests that is used to determine if a subject has been or is currently + infected with a Hepatitis virus, is shedding Hepatitis virus or has immunity + to Hepatitis viruses. + termDef: + term: >- + Hepatitis Serology + source: NCIt + cde_id: C177609 + cde_version: 23.11d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C177609" + term_id: C177609 + term_version: 23.11d + +hormonal_replacement_therapy_status: + common: + description: >- + Indicates whether the patient has ever received hormone replacement therapy. + termDef: + term: >- + Hormone Replacement Therapy Status + source: NCIt + cde_id: C206479 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206479" + term_id: C206479 + term_version: 24.07e + +population_group: + common: + description: >- + A group of individuals united by a common factor (e.g., geographic location, + ethnicity, disease, age, gender). + termDef: + term: >- + Population Group + source: NCIt + cde_id: C17005 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17005" + term_id: C17005 + term_version: 24.07e + +ajcc_serum_tumor_markers: + common: + description: >- + A laboratory test result in which markers for testicular cancer are tested in + a blood sample for staging purposes. + termDef: + term: >- + Testicular Cancer Serum Markers Test Result + source: NCIt + cde_id: C111067 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111067" + term_id: C111067 + term_version: 24.07e + +histologic_progression: + common: + description: >- + The evolution of a low-grade neoplastic pathologic process to a high grade malignancy. + termDef: + term: >- + Histologic Progression + source: NCIt + cde_id: C99318 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99318" + term_id: C99318 + term_version: 24.07e + +tumor_basal_diameter: + common: + description: >- + Numeric value in millimeters for the lowest layer of a tumor. + termDef: + term: >- + Tumor Basal Diameter + source: + cde_id: + cde_version: + term_url: + +intratubular_germ_cell_neoplasia_present: + common: + description: >- + Text term to indicate whether the intratubular germ cell neoplasm is present + or absent. + termDef: + term: >- + Testicular Intratubular Germ Cell Neoplasia Indicator + source: + cde_id: + cde_version: + term_url: + +pretreatment: + common: + description: >- + Any relevant actions that were performed or occurred prior to a specific treatment. + termDef: + term: >- + Pretreatment + source: NCIt + cde_id: C103339 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C103339" + term_id: C103339 + term_version: 24.07e diff --git a/server/data_files/GDC/model-3.3.0/_terms_enum.yaml b/server/data_files/GDC/model-3.3.0/_terms_enum.yaml new file mode 100644 index 0000000..20a3857 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/_terms_enum.yaml @@ -0,0 +1,102725 @@ + +id: _terms_enum + +"0": + common: + description: >- + A mathematical element that when added to another number yields the same number; + the cardinal number meaning one less than one. + termDef: + term: >- + Zero + source: NCIt + cde_id: C70430 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70430" + term_id: C70430 + term_version: 20.05a + diagnosis: + tumor_regression_grade: + description: >- + A score on the Modified Ryan Scheme for Tumor Regression that indicates a + complete response, defined as having no viable cancer cells. + termDef: + term: >- + Tumor Regression Score 0 + source: NCIt + cde_id: C155941 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155941" + term_id: C155941 + term_version: 20.05a + +"1": + exposure: + tobacco_smoking_status: + description: >- + A person who has never smoked at the time of the interview or has smoked less + than 100 cigarettes in their life. + termDef: + term: >- + Never Smoker + source: NCIt + cde_id: C65108 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65108" + term_id: C65108 + term_version: 19.12e + diagnosis: + tumor_regression_grade: + description: >- + A score on the Modified Ryan Scheme for Tumor Regression that indicates a + near complete response, defined as the presence of single cells or rare small + groups of cancer cells. + termDef: + term: >- + Tumor Regression Score 1 + source: NCIt + cde_id: C155942 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155942" + term_id: C155942 + term_version: 20.05a + +"2": + exposure: + tobacco_smoking_status: + description: >- + An adult who has smoked 100 cigarettes in his or her lifetime and who currently + smokes cigarettes. Includes daily smokers and non-daily smokers (also known + as occasional smokers). + termDef: + term: >- + Current Smoker + source: NCIt + cde_id: C67147 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67147" + term_id: C67147 + term_version: 19.12e + diagnosis: + tumor_regression_grade: + description: >- + A score on the Modified Ryan Scheme for Tumor Regression that indicates a + partial response, defined as the presence of residual cancer with evident + tumor regression but more than single cells or rare small groups of cancer + cells. + termDef: + term: >- + Tumor Regression Score 2 + source: NCIt + cde_id: C155943 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155943" + term_id: C155943 + term_version: 20.05a + +"3": + exposure: + tobacco_smoking_status: + description: >- + An individual who stopped smoking more than 15 years prior. + termDef: + term: >- + Current Reformed Smoker, More than 15 Years + source: NCIt + cde_id: C156828 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156828" + term_id: C156828 + term_version: 19.12e + diagnosis: + tumor_regression_grade: + description: >- + A score on the Modified Ryan Scheme for Tumor Regression that indicates poor + or no response, defined as extensive residual cancer with no evident tumor + regression. + termDef: + term: >- + Tumor Regression Score 3 + source: NCIt + cde_id: C155944 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155944" + term_id: C155944 + term_version: 20.05a + +"4": + exposure: + tobacco_smoking_status: + description: >- + An individual who stopped smoking within the past 15 years. + termDef: + term: >- + Current Reformed Smoker Within Past 15 Years + source: NCIt + cde_id: C156829 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156829" + term_id: C156829 + term_version: 19.12e + +"5": + exposure: + tobacco_smoking_status: + description: >- + An individual who stopped smoking an unknown number of years prior. + termDef: + term: >- + Current Reformed Smoker, Years Unknown + source: NCIt + cde_id: C156830 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156830" + term_id: C156830 + term_version: 19.12e + +"6": + exposure: + tobacco_smoking_status: + description: >- + An indication that a person was a smoker at the time they received a pathologic + diagnosis. + termDef: + term: >- + Smoking at Diagnosis + source: NCIt + cde_id: C164079 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164079" + term_id: C164079 + term_version: 19.12e + +"7": + exposure: + tobacco_smoking_status: + description: >- + An indication that the smoking history of an individual is unavailable. + termDef: + term: >- + Smoking History Not Available + source: NCIt + cde_id: C156831 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156831" + term_id: C156831 + term_version: 19.12e + +"13": + common: + description: >- + An indication that cancer cells have been detected in one, two or three lymph + nodes. + termDef: + term: >- + One to Three Positive Lymph Nodes + source: NCIt + cde_id: C172224 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172224" + term_id: C172224 + term_version: 20.10d + +sept5: + common: + description: >- + This gene plays a role in cell division. + termDef: + term: >- + SEPTIN5 Gene + source: NCIt + cde_id: C97727 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97727" + term_id: C97727 + term_version: 20.10d + +sept6: + common: + description: >- + This gene is involved in both cytokinesis and the organization of the actin + cytoskeleton. + termDef: + term: >- + SEPTIN6 Gene + source: NCIt + cde_id: C97782 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97782" + term_id: C97782 + term_version: 20.10d + +sept9: + common: + description: >- + This gene plays a role in actin filament dynamics. + termDef: + term: >- + SEPTIN9 Gene + source: NCIt + cde_id: C97897 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97897" + term_id: C97897 + term_version: 20.10d + +"80000": + common: + description: >- + A neoplasm which is characterized by the absence of morphologic features associated + with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic + rate). Benign neoplasms remain confined to the original site of growth and do + not metastasize to other anatomic sites. + termDef: + term: >- + Benign Neoplasm + source: NCIt + cde_id: C3677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3677" + term_id: C3677 + term_version: 20.05a + +"80001": + common: + description: >- + A neoplasm which, on morphologic grounds, can not be classified with certainty + as benign or malignant. + termDef: + term: >- + Neoplasm, Uncertain Whether Benign or Malignant + source: NCIt + cde_id: C65157 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65157" + term_id: C65157 + term_version: 20.05a + +"80003": + common: + description: >- + A tumor composed of atypical neoplastic, often pleomorphic cells that invade + other tissues. Malignant neoplasms often metastasize to distant anatomic sites + and may recur after excision. The most common malignant neoplasms are carcinomas, + Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. + termDef: + term: >- + Malignant Neoplasm + source: NCIt + cde_id: 'C9305 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9305 " + term_id: 'C9305 ' + term_version: 20.05a + +"80006": + common: + description: >- + A tumor that has spread from its original (primary) site of growth to another + site, close to or distant from the primary site. Metastasis is characteristic + of advanced malignancies, but in rare instances can be seen in neoplasms lacking + malignant morphology. + termDef: + term: >- + Metastatic Neoplasm + source: NCIt + cde_id: 'C3261 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3261 " + term_id: 'C3261 ' + term_version: 20.05a + +"80009": + common: + description: >- + A malignant neoplasm in which the examined tissue can not be determined with + certainty if it represents the primary site of tumor growth or tumor spread + from another anatomic site. + termDef: + term: >- + Malignant Neoplasm, Uncertain Whether Primary or Metastatic + source: NCIt + cde_id: C65153 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65153" + term_id: C65153 + term_version: 20.05a + +"80011": + common: + description: >- + Cells of, or derived from, a tumor. + termDef: + term: >- + Neoplastic Cell + source: NCIt + cde_id: C12922 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12922" + term_id: C12922 + term_version: 20.05a + +"80013": + common: + description: >- + Cells of, or derived from, a malignant tumor. + termDef: + term: >- + Malignant Cell + source: NCIt + cde_id: C12917 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12917" + term_id: C12917 + term_version: 20.05a + +"80023": + common: + description: >- + A malignant neoplasm characterized by the presence of small atypical cells. + termDef: + term: >- + Malignant Tumor, Small Cell Type + source: NCIt + cde_id: C65154 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65154" + term_id: C65154 + term_version: 20.05a + +"80033": + common: + description: >- + A malignant neoplasm characterized by then presence of atypical giant cells. + termDef: + term: >- + Malignant Giant Cell Neoplasm + source: NCIt + cde_id: C4090 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4090" + term_id: C4090 + term_version: 20.05a + +"80043": + common: + description: >- + A malignant neoplasm characterized by the presence of atypical spindle cells. + termDef: + term: >- + Malignant Spindle Cell Neoplasm + source: NCIt + cde_id: C27091 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27091" + term_id: C27091 + term_version: 20.05a + +"80050": + common: + description: >- + A purely morphologic term that describes a neoplasm in which all or the majority + of the neoplastic cells have a clear cytoplasm, when examined under light microscopy, + using the conventional staining method (H-E). This term does not provide any + information about the nature of the neoplasm (benign or malignant), cell of + origin (e.g. epithelial versus mesenchymal versus hematopoietic), or prognosis. + Further examination using special stains and/or immunohistochemistry is required + to appropriately classify this tumor. + termDef: + term: >- + Clear Cell Neoplasm + source: NCIt + cde_id: C66752 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66752" + term_id: C66752 + term_version: 20.05a + +"80100": + common: + description: >- + A neoplasm arising from the epithelial cells. It is characterized by the absence + of morphologic features associated with malignancy (severe cytologic atypia, + tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain + confined to the original site of growth and only rarely metastasize to other + anatomic sites. + termDef: + term: >- + Benign Epithelial Neoplasm + source: NCIt + cde_id: C4092 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4092" + term_id: C4092 + term_version: 20.05a + +"80102": + common: + description: >- + A malignant epithelial neoplasm which is confined to the epithelial layer without + evidence of further tissue invasion. + termDef: + term: >- + Carcinoma In Situ + source: NCIt + cde_id: C2917 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2917" + term_id: C2917 + term_version: 20.05a + +"80103": + common: + description: >- + A malignant tumor arising from epithelial cells. Carcinomas that arise from + glandular epithelium are called adenocarcinomas, those that arise from squamous + epithelium are called squamous cell carcinomas, and those that arise from transitional + epithelium are called transitional cell carcinomas. Morphologically, the malignant + epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. + Carcinomas are graded by the degree of cellular differentiation as well, moderately, + or poorly differentiated. Carcinomas invade the surrounding tissues and tend + to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast + carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen + carcinomas. + termDef: + term: >- + Carcinoma + source: NCIt + cde_id: C2916 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2916" + term_id: C2916 + term_version: 20.05a + +"80106": + common: + description: >- + A carcinoma that has spread from its original site of growth to other anatomic + sites. + termDef: + term: >- + Metastatic Carcinoma + source: NCIt + cde_id: C3482 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3482" + term_id: C3482 + term_version: 20.05a + +"80109": + common: + description: >- + Carcinoma that has spread diffusely to an anatomic site or throughout the body. + termDef: + term: >- + Carcinomatosis + source: NCIt + cde_id: C3693 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3693" + term_id: C3693 + term_version: 20.05a + +"80110": + common: + description: >- + A neoplasm arising from the epithelial cells. It is characterized by the absence + of morphologic features associated with malignancy (severe cytologic atypia, + tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain + confined to the original site of growth and only rarely metastasize to other + anatomic sites. + termDef: + term: >- + Benign Epithelial Neoplasm + source: NCIt + cde_id: C4092 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4092" + term_id: C4092 + term_version: 20.05a + +"80113": + common: + description: >- + A benign or malignant neoplasm that arises from and is composed of epithelial + cells. This category include adenomas, papillomas, and carcinomas. + termDef: + term: >- + Epithelial Neoplasm + source: NCIt + cde_id: C3709 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3709" + term_id: C3709 + term_version: 20.05a + +"80123": + common: + description: >- + A malignant epithelial neoplasm composed of large, atypical cells. + termDef: + term: >- + Large Cell Carcinoma + source: NCIt + cde_id: C3780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3780" + term_id: C3780 + term_version: 20.05a + +"80133": + common: + description: >- + A usually aggressive carcinoma composed of large malignant cells which display + neuroendocrine characteristics. It is characterized by the presence of high + mitotic activity and necrotic changes. The vast majority of cases are positive + for neuron-specific enolase. Representative examples include lung, breast, cervical, + and thymic neuroendocrine carcinomas. + termDef: + term: >- + Large Cell Neuroendocrine Carcinoma + source: NCIt + cde_id: C6875 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6875" + term_id: C6875 + term_version: 20.05a + +"80143": + common: + description: >- + A large cell lung carcinoma characterized by the presence of rhabdoid cells. + termDef: + term: >- + Lung Large Cell Carcinoma with Rhabdoid Phenotype + source: NCIt + cde_id: C6876 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6876" + term_id: C6876 + term_version: 20.05a + +"80153": + common: + description: >- + A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm. + termDef: + term: >- + Glassy Cell Carcinoma + source: NCIt + cde_id: C65159 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65159" + term_id: C65159 + term_version: 20.05a + +"80203": + common: + description: >- + A usually aggressive malignant epithelial neoplasm composed of atypical cells + which do not display evidence of glandular, squamous, or transitional cell differentiation. + termDef: + term: >- + Undifferentiated Carcinoma + source: NCIt + cde_id: C3692 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3692" + term_id: C3692 + term_version: 20.05a + +"80213": + common: + description: >- + A usually aggressive malignant epithelial neoplasm composed of atypical cells + which do not display evidence of glandular, squamous, or transitional cell differentiation. + termDef: + term: >- + Undifferentiated Carcinoma + source: NCIt + cde_id: C3692 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3692" + term_id: C3692 + term_version: 20.05a + +"80223": + common: + description: >- + A usually aggressive malignant epithelial neoplasm composed of cells with significant + cytologic atypia and nuclear pleomorphism. + termDef: + term: >- + Pleomorphic Carcinoma + source: NCIt + cde_id: C4094 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4094" + term_id: C4094 + term_version: 20.05a + +"80233": + common: + description: >- + A rare, highly aggressive and lethal carcinoma that affects children and young + adults. It arises from midline epithelial structures, most commonly the head, + neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized + by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) + is present that results in the creation of a fusion gene involving the NUT gene, + most commonly BRD4-NUT fusion gene. + termDef: + term: >- + NUT Carcinoma + source: NCIt + cde_id: C45716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45716" + term_id: C45716 + term_version: 20.05a + +"80303": + common: + description: >- + A malignant epithelial neoplasm composed of giant, pleomorphic cells and spindle + cells. + termDef: + term: >- + Giant Cell and Spindle Cell Carcinoma + source: NCIt + cde_id: C65160 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65160" + term_id: C65160 + term_version: 20.05a + +"80313": + common: + description: >- + A malignant epithelial neoplasm composed of giant, pleomorphic cells. + termDef: + term: >- + Giant Cell Carcinoma + source: NCIt + cde_id: C3779 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3779" + term_id: C3779 + term_version: 20.05a + +"80323": + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of spindle cells + and anaplastic morphologic features. Giant cells and a sarcomatous component + may also be present. + termDef: + term: >- + Sarcomatoid Carcinoma + source: NCIt + cde_id: C27004 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27004" + term_id: C27004 + term_version: 20.05a + +"80333": + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of spindle cells + and anaplastic morphologic features. Giant cells and a sarcomatous component + may also be present. + termDef: + term: >- + Sarcomatoid Carcinoma + source: NCIt + cde_id: C27004 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27004" + term_id: C27004 + term_version: 20.05a + +"80343": + common: + description: >- + A malignant epithelial neoplasm composed of atypical polygonal cells with a + large amount of eosinophilic cytoplasm. A representative example is the fibrolamellar + hepatocellular carcinoma. + termDef: + term: >- + Polygonal Cell Carcinoma + source: NCIt + cde_id: C65161 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65161" + term_id: C65161 + term_version: 20.05a + +"80400": + common: + description: >- + A tiny localized pulmonary nodule characterized by neuroendocrine cell proliferation. + It is usually discovered as an incidental finding during routine histologic + examination of tissue sections or during radiologic examination. + termDef: + term: >- + Tumorlet + source: NCIt + cde_id: C65162 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65162" + term_id: C65162 + term_version: 20.05a + +"80413": + common: + description: >- + A neuroendocrine carcinoma composed of small malignant cells which are often + said to resemble "oat cells" under the microscope. Small cell carcinoma most + often affects the lungs. Clinically, this is often a rapidly growing cancer + that spreads to distant sites early. + termDef: + term: >- + Small Cell Carcinoma + source: NCIt + cde_id: C3915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3915" + term_id: C3915 + term_version: 20.05a + +"80423": + common: + description: >- + A neuroendocrine carcinoma composed of small malignant cells which are often + said to resemble "oat cells" under the microscope. Small cell carcinoma most + often affects the lungs. Clinically, this is often a rapidly growing cancer + that spreads to distant sites early. + termDef: + term: >- + Small Cell Carcinoma + source: NCIt + cde_id: C3915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3915" + term_id: C3915 + term_version: 20.05a + +"80433": + common: + description: >- + A neuroendocrine carcinoma composed of malignant fusiform small cells. + termDef: + term: >- + Small Cell Carcinoma, Fusiform Cell Type + source: NCIt + cde_id: C27092 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27092" + term_id: C27092 + term_version: 20.05a + +"80443": + common: + description: >- + A neuroendocrine carcinoma composed of malignant small cells of intermediate + shape. + termDef: + term: >- + Small Cell Intermediate Cell Carcinoma + source: NCIt + cde_id: C4099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4099" + term_id: C4099 + term_version: 20.05a + +"80453": + common: + description: >- + A morphologic variant of small cell lung carcinoma in combination with a non-small + cell carcinoma. + termDef: + term: >- + Combined Lung Small Cell Carcinoma + source: NCIt + cde_id: C9137 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9137" + term_id: C9137 + term_version: 20.05a + +"80463": + common: + description: >- + A malignant epithelial neoplasm characterized by the absence of neoplastic small + epithelial cells. A representative example is the lung non-small cell carcinoma. + termDef: + term: >- + Non-Small Cell Carcinoma + source: NCIt + cde_id: C65151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65151" + term_id: C65151 + term_version: 20.05a + +"80500": + common: + description: >- + A benign epithelial neoplasm that projects above the surrounding epithelial + surface and consists of villous or arborescent outgrowths of fibrovascular stroma. + termDef: + term: >- + Papilloma + source: NCIt + cde_id: C7440 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7440" + term_id: C7440 + term_version: 20.05a + +"80502": + common: + description: >- + An epithelial neoplasm with a papillary growth pattern in which the malignant + cells are confined to the epithelium, without evidence of invasion. + termDef: + term: >- + Papillary Carcinoma In Situ + source: NCIt + cde_id: C65163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65163" + term_id: C65163 + term_version: 20.05a + +"80503": + common: + description: >- + A malignant epithelial neoplasm characterized by a papillary growth pattern. + A papillary carcinoma may be composed of glandular cells (papillary adenocarcinoma), + squamous cells (papillary squamous cell carcinoma), or transitional cells (papillary + transitional cell carcinoma). Bladder carcinoma is a representative example + of papillary transitional cell carcinoma. + termDef: + term: >- + Papillary Carcinoma + source: NCIt + cde_id: C2927 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2927" + term_id: C2927 + term_version: 20.05a + +"80510": + common: + description: >- + A benign epithelial neoplasm characterized by a papillary growth pattern, lack + of significant cytologic atypia, and a wart-like appearance. + termDef: + term: >- + Verrucous Papilloma + source: NCIt + cde_id: C4101 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4101" + term_id: C4101 + term_version: 20.05a + +"80513": + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary growth + pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most + commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, + esophagus, anus, vagina, vulva, and the plantar region of the foot. + termDef: + term: >- + Verrucous Carcinoma + source: NCIt + cde_id: C3781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3781" + term_id: C3781 + term_version: 20.05a + +"80520": + common: + description: >- + A benign epithelial neoplasm characterized by a papillary growth pattern and + a proliferation of neoplastic squamous cells without morphologic evidence of + malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, + esophagus, vagina, and vulva. + termDef: + term: >- + Squamous Cell Papilloma + source: NCIt + cde_id: C3712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3712" + term_id: C3712 + term_version: 20.05a + +"80522": + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary, + exophytic growth pattern, hyperkeratosis, and absence of invasion of adjacent + tissues. + termDef: + term: >- + Non-Invasive Papillary Squamous Cell Carcinoma + source: NCIt + cde_id: C65164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65164" + term_id: C65164 + term_version: 20.05a + +"80523": + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary, + exophytic growth pattern and hyperkeratosis. The most commonly affected anatomic + sites are the larynx, penis, cervix, vagina, and vulva. + termDef: + term: >- + Papillary Squamous Cell Carcinoma + source: NCIt + cde_id: C4102 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4102" + term_id: C4102 + term_version: 20.05a + +"80530": + common: + description: >- + A benign epithelial neoplasm characterized by an endophytic growth, papillary + pattern, and proliferation of neoplastic squamous cells without morphologic + evidence of malignancy. + termDef: + term: >- + Inverted Squamous Cell Papilloma + source: NCIt + cde_id: C65165 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65165" + term_id: C65165 + term_version: 20.05a + +"80600": + common: + description: >- + A benign squamous neoplasm characterized by a papillary growth pattern, diffusely + involving a specific anatomic site. + termDef: + term: >- + Squamous Papillomatosis + source: NCIt + cde_id: 'C9009 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9009 " + term_id: 'C9009 ' + term_version: 20.05a + +"80702": + common: + description: >- + A malignant epithelial neoplasm confined to the squamous epithelium, without + invasion of the underlying tissues. + termDef: + term: >- + Stage 0 Squamous Cell Carcinoma + source: NCIt + cde_id: C27093 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27093" + term_id: C27093 + term_version: 20.05a + +"80703": + common: + description: >- + A carcinoma arising from squamous epithelial cells. Morphologically, it is + characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous + cell carcinomas are graded by the degree of cellular differentiation as well, + moderately, or poorly differentiated. Well differentiated carcinomas are usually + associated with keratin production and the presence of intercellular bridges + between adjacent cells. Representative examples are lung squamous cell carcinoma, + skin squamous cell carcinoma, and cervical squamous cell carcinoma. + termDef: + term: >- + Squamous Cell Carcinoma + source: NCIt + cde_id: C2929 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2929" + term_id: C2929 + term_version: 20.05a + +"80706": + common: + description: >- + A carcinoma that arises from squamous cells and has spread from its original + site of growth to another anatomic site. + termDef: + term: >- + Metastatic Squamous Cell Carcinoma + source: NCIt + cde_id: C4104 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4104" + term_id: C4104 + term_version: 20.05a + +"80712": + common: + description: >- + Squamous cell carcinomas with morphologically prominent production of keratin. + termDef: + term: >- + Keratinizing Squamous Cell Carcinoma + source: NCIt + cde_id: C4105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4105" + term_id: C4105 + term_version: 20.05a + +"80713": + common: + description: >- + Squamous cell carcinomas with morphologically prominent production of keratin. + termDef: + term: >- + Keratinizing Squamous Cell Carcinoma + source: NCIt + cde_id: C4105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4105" + term_id: C4105 + term_version: 20.05a + +"80723": + common: + description: >- + A squamous cell carcinoma composed of large atypical cells, without morphologic + evidence of keratin production. + termDef: + term: >- + Non-Keratinizing Large Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C65173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65173" + term_id: C65173 + term_version: 20.05a + +"80733": + common: + description: >- + A squamous cell carcinoma composed of small atypical cells, without morphologic + evidence of keratin production. + termDef: + term: >- + Non-Keratinizing Small Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C65175 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65175" + term_id: C65175 + term_version: 20.05a + +"80743": + common: + description: >- + A poorly differentiated squamous cell carcinoma characterized by the presence + of malignant cells with spindle cell features. + termDef: + term: >- + Spindle Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C27084 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27084" + term_id: C27084 + term_version: 20.05a + +"80753": + common: + description: >- + A squamous cell carcinoma characterized by the formation of gland-like structures. + termDef: + term: >- + Pseudoglandular Squamous Cell Carcinoma + source: NCIt + cde_id: C4106 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4106" + term_id: C4106 + term_version: 20.05a + +"80762": + common: + description: >- + A malignant epithelial neoplasm involving all the layers of the squamous epithelium, + but it is not certain if it is confined to the squamous epithelium or it has + invaded the basement membrane and the underlying stroma. + termDef: + term: >- + Squamous Cell Carcinoma In Situ with Questionable Stromal Invasion + source: NCIt + cde_id: C65176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65176" + term_id: C65176 + term_version: 20.05a + +"80763": + common: + description: >- + A squamous cell carcinoma with minimal stromal invasion. + termDef: + term: >- + Microinvasive Squamous Cell Carcinoma + source: NCIt + cde_id: C65178 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65178" + term_id: C65178 + term_version: 20.05a + +"80770": + common: + description: >- + A precancerous neoplastic process characterized by the presence of mild dysplastic + cytological changes which are usually present in the lower part of the squamous + epithelium. Representative examples include the low grade esophageal squamous + intraepithelial neoplasia, low grade cervical squamous intraepithelial neoplasia, + low grade vaginal intraepithelial neoplasia, and low grade vulvar intraepithelial + neoplasia. + termDef: + term: >- + Low Grade Squamous Intraepithelial Neoplasia + source: NCIt + cde_id: 'C8335 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8335 " + term_id: 'C8335 ' + term_version: 20.05a + +"80772": + common: + description: >- + A precancerous neoplastic process characterized by the presence of moderate + or severe dysplastic cytological changes which extend to the upper part of the + squamous epithelium. Maturation at the surface of the squamous epithelium may + or may not be present. Representative examples include the high grade esophageal + squamous intraepithelial neoplasia, high grade cervical squamous intraepithelial + neoplasia, high grade vaginal intraepithelial neoplasia, and high grade vulvar + intraepithelial neoplasia. + termDef: + term: >- + High Grade Squamous Intraepithelial Neoplasia + source: NCIt + cde_id: 'C8336 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8336 " + term_id: 'C8336 ' + term_version: 20.05a + +"80783": + common: + description: >- + A keratinizing squamous cell carcinoma characterized by the presence of horn + pearls. Representative examples include squamous cell carcinomas of the face + presenting as a cutaneous horn. + termDef: + term: >- + Squamous Cell Carcinoma with Horn Formation + source: NCIt + cde_id: C65179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65179" + term_id: C65179 + term_version: 20.05a + +"80802": + common: + description: >- + Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. cN0: No palpable or + visibly enlarged inguinal lymph nodes. pN0: No regional lymph node metastasis. M0: + No distant metastasis. (AJCC 7th ed.) + termDef: + term: >- + Penile Carcinoma In Situ + source: NCIt + cde_id: C27790 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27790" + term_id: C27790 + term_version: 20.05a + +"80812": + common: + description: >- + A form of squamous cell carcinoma in situ. It is a distinct clinicopathological + entity and arises from the skin or the mucocutaneous junction. It affects predominantly + white males in their 6-8th decades of life. Exposed and non-exposed skin sites + are equally affected. UV damage and ingestion of inorganic arsenic may play + a role in the development of the disease. On the skin surface, it presents as + a single or multiple erythematous, scaly, keratotic patches or plaques. The + clinical entity of erythroplasia of Queyrat is regarded as Bowen disease of + the penis and it presents as an asymptomatic, red, circumscribed plaque. Morphologically, + Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, + dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and + display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement + membrane is intact. Complete surgical removal of the lesion may be curative. + termDef: + term: >- + Bowen Disease of the Skin + source: NCIt + cde_id: C62571 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62571" + term_id: C62571 + term_version: 20.05a + +"80823": + common: + description: >- + A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but + also in the tonsils and rarely in other anatomic sites. It is characterized + by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, + syncytial growth pattern, and a lymphoplasmacytic infiltrate. + termDef: + term: >- + Nasopharyngeal-Type Undifferentiated Carcinoma + source: NCIt + cde_id: C4107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4107" + term_id: C4107 + term_version: 20.05a + +"80833": + common: + description: >- + A squamous cell carcinoma characterized by the presence of cells with hyperchromatic + nuclei, scant amount of cytoplasm, and peripheral nuclear palisading. + termDef: + term: >- + Basaloid Squamous Cell Carcinoma + source: NCIt + cde_id: C54244 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54244" + term_id: C54244 + term_version: 20.05a + +"80843": + common: + description: >- + A squamous cell carcinoma characterized by the presence of malignant cells with + clear cytoplasm. + termDef: + term: >- + Squamous Cell Carcinoma, Clear Cell Type + source: NCIt + cde_id: C65180 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65180" + term_id: C65180 + term_version: 20.05a + +"80853": + common: + description: >- + Human Papillomavirus-Related Squamous Cell Carcinoma + termDef: + term: >- + Human Papillomavirus-Related Squamous Cell Carcinoma + source: NCIt + cde_id: C27683 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27683" + term_id: C27683 + term_version: 20.05a + +"80901": + common: + description: >- + A neoplastic proliferation of basal cells in the epidermis (part of the skin) + or other anatomic sites (most frequently the salivary glands). The basal cell + neoplastic proliferation in the epidermis results in basal cell carcinomas. The + basal cell neoplastic proliferation in the salivary glands can be benign, resulting + in basal cell adenomas or malignant, resulting in basal cell adenocarcinomas. + termDef: + term: >- + Basal Cell Neoplasm + source: NCIt + cde_id: C3784 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3784" + term_id: C3784 + term_version: 20.05a + +"80903": + common: + description: >- + The most frequently seen skin cancer. It arises from basal cells of the epidermis + and pilosebaceous units. Clinically it is divided into the following types: + nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing + or morphea-like. More than 95% of these carcinomas occur in patients over 40. + They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately + 85% are found on the head and neck and the remaining 15% on the trunk and extremities. + Basal cell carcinoma usually grows in a slow and indolent fashion. However, + if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and + bone. Distant metastases are rare. Excision, curettage and irradiation cure + most basal cell carcinomas. + termDef: + term: >- + Skin Basal Cell Carcinoma + source: NCIt + cde_id: 'C2921 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2921 " + term_id: 'C2921 ' + term_version: 20.05a + +"80913": + common: + description: >- + A superficial basal cell carcinoma of the skin characterized by the presence + of lobules of basaloid cells which are separated by large distances and represent + multifocal discrete tumors. + termDef: + term: >- + Superficial Multifocal Basal Cell Carcinoma + source: NCIt + cde_id: C4108 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4108" + term_id: C4108 + term_version: 20.05a + +"80923": + common: + description: >- + A variant of basal cell carcinoma presenting as a pale, indurated plaque, usually + in the upper trunk or face. Morphologically, it is characterized by the presence + of strands, cords, and columns of basaloid cells infiltrating the dermis. Perineural + invasion may be present and the basaloid cell infiltrate may extend into deeper + tissues. + termDef: + term: >- + Skin Infiltrating Basal Cell Carcinoma + source: NCIt + cde_id: 'C27539 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27539 " + term_id: 'C27539 ' + term_version: 20.05a + +"80933": + common: + description: >- + A variant of basal cell carcinoma presenting as an elevated or erythematous + nodular lesion usually in the back. Morphologically, it is characterized by + the presence of cords of basaloid cells extending from the epidermis into the + dermis, creating a fenestrating pattern. It follows an indolent course. + termDef: + term: >- + Skin Fibroepithelial Basal Cell Carcinoma + source: NCIt + cde_id: C4109 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4109" + term_id: C4109 + term_version: 20.05a + +"80943": + common: + description: >- + A basal cell carcinoma which displays squamous differentiation. The neoplastic + cells have more abundant cytoplasm with more marked keratinization than typical + basal cell carcinomas. It usually has a more aggressive clinical course compared + to typical basal cell carcinoma, and it may produce regional or widespread metastases. + termDef: + term: >- + Skin Basosquamous Cell Carcinoma + source: NCIt + cde_id: C2922 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2922" + term_id: C2922 + term_version: 20.05a + +"80953": + common: + description: >- + A skin carcinoma displaying cytological characteristics intermediate to nodular + basal cell carcinoma and squamous cell carcinoma. + termDef: + term: >- + Skin Metatypical Carcinoma + source: NCIt + cde_id: C66903 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66903" + term_id: C66903 + term_version: 20.05a + +"80960": + common: + description: >- + A rare cutaneous lesion presenting as a scaly verrucous plaque. Morphologically, + the plaque contains nests of basaloid cells. + termDef: + term: >- + Intraepidermal Epithelioma of Jadassohn + source: NCIt + cde_id: C4110 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4110" + term_id: C4110 + term_version: 20.05a + +"80973": + common: + description: >- + A basal cell carcinoma of the skin that often appears as elevated nodules which + may become ulcerated. + termDef: + term: >- + Skin Nodular Basal Cell Carcinoma + source: NCIt + cde_id: 'C62282 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62282 " + term_id: 'C62282 ' + term_version: 20.05a + +"80983": + common: + description: >- + A variant of basal cell carcinoma morphologically characterized by the presence + of thin strands of basaloid cells forming a reticulate pattern. + termDef: + term: >- + Skin Adenoid Basal Cell Carcinoma + source: NCIt + cde_id: C27535 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27535" + term_id: C27535 + term_version: 20.05a + +"81000": + common: + description: >- + A benign hair follicle neoplasm with trichoblastic differentiation. It usually + presents as a solitary papular lesion It most often presents on the head and + neck area, but it may develop in any anatomic site containing hair follicles. + Because of its benign nature, treatment usually is not required, provided that + the diagnosis has been established with certainty. + termDef: + term: >- + Trichoblastoma + source: NCIt + cde_id: C27132 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27132" + term_id: C27132 + term_version: 20.05a + +"81010": + common: + description: >- + A skin appendage neoplasm with follicular differentiation. It usually occurs + in the head and neck region, particularly the face. It presents as a solitary + dome-shaped small lesion. The clinical course is benign. + termDef: + term: >- + Trichofolliculoma + source: NCIt + cde_id: C4112 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4112" + term_id: C4112 + term_version: 20.05a + +"81020": + common: + description: >- + A benign neoplasm arising from the outer hair sheath and infundibulum. It occurs + in the head and neck, usually on the face. It usually presents as an exophytic + wart-like lesion or a dome-shaped lesion with smooth surface. Multiple facial + lesions are usually associated with Cowden disease. + termDef: + term: >- + Trichilemmoma + source: NCIt + cde_id: C4113 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4113" + term_id: C4113 + term_version: 20.05a + +"81023": + common: + description: >- + A rare malignant tumor arising from the outer hair sheath and infundibulum on + the face. It is considered the malignant counterpart of tricholemmoma. Complete + surgical excision is required. + termDef: + term: >- + Trichilemmal Carcinoma + source: NCIt + cde_id: C43326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43326" + term_id: C43326 + term_version: 20.05a + +"81030": + common: + description: >- + A neoplasm with tricholemmal differentiation. It affects women more frequently + than men. It usually presents on the scalp as a solitary, multilobular, large, + exophytic mass. Morphologically, it may display benign cytological features + and appear as a circumscribed solid-cystic neoplasm or it may display malignant + characteristics and invasive features. Cases without malignant characteristics + usually have an indolent course. Complete surgical excision is recommended in + such cases to avoid recurrences and to allow complete examination of the specimen. + Cases with malignant characteristics may have a locally aggressive clinical + course, recur, or metastasize. + termDef: + term: >- + Proliferating Trichilemmal Tumor + source: NCIt + cde_id: C27125 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27125" + term_id: C27125 + term_version: 20.05a + +"81100": + common: + description: >- + A benign adnexal neoplasm arising from hair-bearing skin surfaces, usually the + head and neck and upper extremities. It usually presents as a solitary, slow-growing + nodular mass. Morphologically, it displays differentiation towards the matrix + and inner sheath of the normal hair follicle and the hair cortex. Complete surgical + excision is usually curative. Occasionally, it may recur. + termDef: + term: >- + Pilomatricoma + source: NCIt + cde_id: C7368 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7368" + term_id: C7368 + term_version: 20.05a + +"81103": + common: + description: >- + A very rare, locally aggressive, malignant neoplasm of the hair follicle. The + majority of the cases arise de novo, however malignant transformation from a + pre-existing pilomatricoma has been reported. It usually presents as a solitary + nodule in the head and neck, upper extremities, or buttocks. Morphologically, + it is characterized by the presence of aggregates of basaloid cells infiltrating + the dermis. Masses of ghost cells are present in the cellular aggregates. Complete + surgical excision is the treatment of choice. If it is not completely removed, + it usually recurs, but it rarely metastasizes to distant anatomic sites. + termDef: + term: >- + Pilomatrical Carcinoma + source: NCIt + cde_id: C4114 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4114" + term_id: C4114 + term_version: 20.05a + +"81200": + common: + description: >- + A benign papillary neoplasm composed of transitional cells which show preservation + of the nuclear polarity. + termDef: + term: >- + Transitional Cell Papilloma + source: NCIt + cde_id: C4115 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4115" + term_id: C4115 + term_version: 20.05a + +"81201": + common: + description: >- + A rare benign condition, characterized by a papillary growth in the urinary + tract with a central fibrovascular core. The latter is lined by normal urothelium. + termDef: + term: >- + Urothelial Papilloma + source: NCIt + cde_id: 'C3842 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3842 " + term_id: 'C3842 ' + term_version: 20.05a + +"81202": + common: + description: >- + A lesion in which the surface epithelium of the bladder or the renal pelvis + and ureter contains transitional cells which display malignant cytologic characteristics. There + is no evidence of stromal invasion. + termDef: + term: >- + Stage 0 Transitional Cell Carcinoma + source: NCIt + cde_id: C4116 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4116" + term_id: C4116 + term_version: 20.05a + +"81203": + common: + description: >- + A malignant neoplasm arising from the transitional epithelium, usually affecting + the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary + configuration. It is graded 1 to 3 or 4 according to the degree of cellular + differentiation and architectural patterns. Grade 1 transitional cell carcinoma + is histologically benign but it may recur. Transitional cell carcinomas may + also affect the upper respiratory tract and the ovaries. + termDef: + term: >- + Transitional Cell Carcinoma + source: NCIt + cde_id: 'C2930 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2930 " + term_id: 'C2930 ' + term_version: 20.05a + +"81210": + common: + description: >- + A benign neoplasm that arises from the ciliated respiratory mucosa that lines + the nasal cavity and paranasal sinuses. It is classified as inverted papilloma, + oncocytic papilloma, and exophytic papilloma. Clinical manifestations include + nasal obstruction, epistaxis, and anosmia. + termDef: + term: >- + Sinonasal Schneiderian Papilloma + source: NCIt + cde_id: 'C4117 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4117 " + term_id: 'C4117 ' + term_version: 20.05a + +"81211": + common: + description: >- + A benign papillary neoplasm composed of transitional cells and characterized + by an endophytic growth pattern. + termDef: + term: >- + Inverted Transitional Cell Papilloma + source: NCIt + cde_id: 'C4118 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4118 " + term_id: 'C4118 ' + term_version: 20.05a + +"81213": + common: + description: >- + A squamous cell carcinoma of the sinonasal tract characterized by a plexiform + or ribbon-like growth pattern, cytological atypia, and lack of histological + evidence of keratinization. + termDef: + term: >- + Non-Keratinizing Sinonasal Squamous Cell Carcinoma + source: NCIt + cde_id: C54287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54287" + term_id: C54287 + term_version: 20.05a + +"81223": + common: + description: >- + A poorly differentiated transitional cell carcinoma characterized by the presence + of malignant cells with spindle cell morphologic features. + termDef: + term: >- + Sarcomatoid Transitional Cell Carcinoma + source: NCIt + cde_id: C4120 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4120" + term_id: C4120 + term_version: 20.05a + +"81233": + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of neoplastic + cells with hyperchromatic nuclei, small amount of cytoplasm, and peripheral + nuclear palisading. + termDef: + term: >- + Basaloid Carcinoma + source: NCIt + cde_id: C4121 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4121" + term_id: C4121 + term_version: 20.05a + +"81243": + common: + description: >- + An anal carcinoma arising from the transitional zone of the anal canal. + termDef: + term: >- + Anal Canal Cloacogenic Carcinoma + source: NCIt + cde_id: C8255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8255" + term_id: C8255 + term_version: 20.05a + +"81301": + common: + description: >- + A papillary neoplasm of the urinary bladder in which the transitional cells + form papillae. The papillary structures exhibit minimal architectural distortion + and minimal atypia. Mitoses are infrequent. Patients are at an increased risk + of developing new papillary lesions. Occasionally, the new lesions are urothelial + carcinomas. + termDef: + term: >- + Bladder Papillary Urothelial Neoplasm of Low Malignant Potential + source: NCIt + cde_id: C27884 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27884" + term_id: C27884 + term_version: 20.05a + +"81302": + common: + description: >- + A transitional cell carcinoma characterized by a papillary growth pattern and + lack of stromal invasion. + termDef: + term: >- + Non-Invasive Papillary Transitional Cell Carcinoma + source: NCIt + cde_id: C65181 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65181" + term_id: C65181 + term_version: 20.05a + +"81303": + common: + description: >- + A non-invasive or invasive transitional cell carcinoma characterized by a papillary + growth pattern. It may occur in the bladder or the renal pelvis. + termDef: + term: >- + Papillary Transitional Cell Carcinoma + source: NCIt + cde_id: C4122 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4122" + term_id: C4122 + term_version: 20.05a + +"81313": + common: + description: >- + A transitional cell carcinoma characterized by a micropapillary growth pattern. + Typical example is the micropapillary variant of infiltrating bladder urothelial + carcinoma. + termDef: + term: >- + Micropapillary Transitional Cell Carcinoma + source: NCIt + cde_id: C65182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65182" + term_id: C65182 + term_version: 20.05a + +"81400": + common: + description: >- + A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated + but non-invasive. The neoplastic epithelial cells may or may not display cellular + atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes + severe it is sometimes called carcinoma in situ. Representative examples are + pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas + (or adenomatous polyps) of the gastrointestinal tract. + termDef: + term: >- + Adenoma + source: NCIt + cde_id: C2855 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2855" + term_id: C2855 + term_version: 20.05a + +"81401": + common: + description: >- + An adenoma characterized by increased cellularity and nuclear atypia without + evidence of vascular or capsular invasion. A representative example is thyroid + gland atypical follicular adenoma. + termDef: + term: >- + Atypical Adenoma + source: NCIt + cde_id: 'C7559 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7559 " + term_id: 'C7559 ' + term_version: 20.05a + +"81402": + common: + description: >- + A lesion in which the normally situated glands are partially or completely replaced + by atypical cells with malignant characteristics. + termDef: + term: >- + Adenocarcinoma In Situ + source: NCIt + cde_id: C4123 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4123" + term_id: C4123 + term_version: 20.05a + +"81403": + common: + description: >- + A common cancer characterized by the presence of malignant glandular cells. Morphologically, + adenocarcinomas are classified according to the growth pattern (e.g., papillary, + alveolar) or according to the secreting product (e.g., mucinous, serous). Representative + examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, + renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, + and prostate adenocarcinoma. + termDef: + term: >- + Adenocarcinoma + source: NCIt + cde_id: C2852 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2852" + term_id: C2852 + term_version: 20.05a + +"81406": + common: + description: >- + An adenocarcinoma that has spread from its original site of growth to another + anatomic site. + termDef: + term: >- + Metastatic Adenocarcinoma + source: NCIt + cde_id: C4124 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4124" + term_id: C4124 + term_version: 20.05a + +"81413": + common: + description: >- + An infiltrating adenocarcinoma characterized by the presence of desmoplastic + stromal reaction. + termDef: + term: >- + Scirrhous Adenocarcinoma + source: NCIt + cde_id: C2928 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2928" + term_id: C2928 + term_version: 20.05a + +"81423": + common: + description: >- + A cancer-related condition in which the gastric wall becomes thickened and rubbery + (leather-bottle stomach). It is most often associated with diffuse gastric adenocarcinomas. + termDef: + term: >- + Linitis Plastica + source: NCIt + cde_id: C3190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3190" + term_id: C3190 + term_version: 20.05a + +"81433": + common: + description: >- + An adenocarcinoma which has spread within the mucosa without further invasion + of the underlying tissues. + termDef: + term: >- + Superficial Spreading Adenocarcinoma + source: NCIt + cde_id: C4125 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4125" + term_id: C4125 + term_version: 20.05a + +"81443": + common: + description: >- + An adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. + Representative examples include gastric, gallbladder, and ampulla of Vater intestinal + type adenocarcinomas. + termDef: + term: >- + Intestinal-Type Adenocarcinoma + source: NCIt + cde_id: C4126 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4126" + term_id: C4126 + term_version: 20.05a + +"81453": + common: + description: >- + An adenocarcinoma characterized by the presence of a diffuse cellular infiltrate + which is composed of poorly cohesive cells with minimal or no glandular formations. + Representative example is the gastric diffuse adenocarcinoma. + termDef: + term: >- + Diffuse Type Adenocarcinoma + source: NCIt + cde_id: C4127 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4127" + term_id: C4127 + term_version: 20.05a + +"81460": + common: + description: >- + A benign epithelial neoplasm arising from the salivary glands. It is characterized + by the presence of a monomorphic cellular infiltrate. + termDef: + term: >- + Salivary Gland Monomorphic Adenoma + source: NCIt + cde_id: C3686 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3686" + term_id: C3686 + term_version: 20.05a + +"81470": + common: + description: >- + A benign epithelial neoplasm with a uniform, monomorphic appearance that is + dominated by basal cells forming trabecular structures. It is rare, and occurs + mostly on the parotid gland. The average age of patients has been reported to + be 58 years. Swelling is the most constant clinical finding. + termDef: + term: >- + Salivary Gland Basal Cell Adenoma + source: NCIt + cde_id: C5950 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5950" + term_id: C5950 + term_version: 20.05a + +"81473": + common: + description: >- + A rare adenocarcinoma of the major and minor salivary glands, originating from + basaloid, myoepithelial and ductal cells. While morphologically resembling + basal cell carcinomas, it is a distinct entity. The tumor is not encapsulated, + may invade locally, and less frequently may metastasize. It usually occurs + in older patients. + termDef: + term: >- + Salivary Gland Basal Cell Adenocarcinoma + source: NCIt + cde_id: C3678 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3678" + term_id: C3678 + term_version: 20.05a + +"81480": + common: + description: >- + Low Grade Glandular Intraepithelial Neoplasia + termDef: + term: >- + Low Grade Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: 'C7661 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7661 " + term_id: 'C7661 ' + term_version: 20.05a + +"81482": + common: + description: >- + This lesion shows moderate or marked architectural distortion with glandular + crowding and prominent cellular atypia. It includes moderate dysplasia and + severe dysplasia. (WHO, 2000) + termDef: + term: >- + High Grade Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: 'C7662 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7662 " + term_id: 'C7662 ' + term_version: 20.05a + +"81500": + common: + description: >- + A benign endocrine neoplasm arising from the pancreas. It is separated from + the normal pancreatic tissues by a thin collagenous capsule. It may secrete + a hormone (e.g. insulin, gastrin) or it may be non-functional. + termDef: + term: >- + Islet Cell Adenoma + source: NCIt + cde_id: C65184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65184" + term_id: C65184 + term_version: 20.05a + +"81501": + common: + description: >- + A neoplasm with neuroendocrine differentiation that arises from the pancreas. It + includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine + carcinomas (high grade). + termDef: + term: >- + Pancreatic Neuroendocrine Neoplasm + source: NCIt + cde_id: C27031 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27031" + term_id: C27031 + term_version: 20.05a + +"81503": + common: + description: >- + An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine + differentiation that arises from the pancreas. The mitotic count is more than + 20 per 10 HPF. According to the size of the malignant cells, the prominence + of the nucleoli, and the amount of cytoplasm, it is classified either as small + or large cell neuroendocrine carcinoma. + termDef: + term: >- + Pancreatic Neuroendocrine Carcinoma + source: NCIt + cde_id: C3770 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3770" + term_id: C3770 + term_version: 20.05a + +"81510": + common: + description: >- + An insulin-producing neuroendocrine tumor arising from the beta cells of the + pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate + secretion of insulin. + termDef: + term: >- + Pancreatic Insulinoma + source: NCIt + cde_id: 'C95598 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95598 " + term_id: 'C95598 ' + term_version: 20.05a + +"81513": + common: + description: >- + An insulin-producing neuroendocrine tumor arising from the beta cells of the + pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate + secretion of insulin. It displays vascular invasion and metastasizes to other + anatomic sites. + termDef: + term: >- + Malignant Pancreatic Insulinoma + source: NCIt + cde_id: C65186 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65186" + term_id: C65186 + term_version: 20.05a + +"81521": + common: + description: >- + An endocrine neoplasm producing glucagon. + termDef: + term: >- + Enteroglucagonoma + source: NCIt + cde_id: C66925 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66925" + term_id: C66925 + term_version: 20.05a + +"81523": + common: + description: >- + A glucagon-producing neuroendocrine tumor arising from the alpha cells of the + pancreas. It may be associated with necrolytic erythema migrans, diarrhea, + diabetes, glossitis, weight loss, malabsorption, and anemia. It displays vascular + invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Pancreatic Glucagonoma + source: NCIt + cde_id: 'C65187 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65187 " + term_id: 'C65187 ' + term_version: 20.05a + +"81531": + common: + description: >- + A gastrin-producing neuroendocrine tumor. It is usually located in the pancreas + but it is also found at other anatomic sites, including the stomach and small + intestine. + termDef: + term: >- + Gastrin-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C3050 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3050" + term_id: C3050 + term_version: 20.05a + +"81533": + common: + description: >- + A gastrin-producing neuroendocrine tumor. It is characterized by inappropriate + secretion of gastrin and associated with Zollinger Ellison syndrome. It displays + vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Gastrinoma + source: NCIt + cde_id: C65188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65188" + term_id: C65188 + term_version: 20.05a + +"81543": + common: + description: >- + A carcinoma that arises from the pancreas showing a mixture of ductal and neuroendocrine + malignant cells in both the primary tumor and in the metastatic sites. + termDef: + term: >- + Mixed Ductal-Neuroendocrine Carcinoma of the Pancreas + source: NCIt + cde_id: C6879 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6879" + term_id: C6879 + term_version: 20.05a + +"81551": + common: + description: >- + An often clinically aggressive neuroendocrine tumor located in the pancreas + or small intestine. It is composed of cells containing vasoactive intestinal + peptide. It may cause intractable diarrhea and metabolic disturbances. + termDef: + term: >- + VIP-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C26749 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26749" + term_id: C26749 + term_version: 20.05a + +"81553": + common: + description: >- + An aggressive neuroendocrine tumor located in the pancreas or small intestine. + It is composed of cells containing vasoactive intestinal peptide. It is associated + with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria. It displays + vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Vipoma + source: NCIt + cde_id: C65189 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65189" + term_id: C65189 + term_version: 20.05a + +"81561": + common: + description: >- + A rare, usually malignant neuroendocrine tumor arizing from delta cells. This + neoplasm produces large amounts of somatostatin, which may result in a syndrome + characterized by diarrhea, steatorrhea, weight loss, and gastric hyposecretion. + Sixty percent are found in the pancreas and 40% in the duodenum or jejunum. + The peak incidence occurs between 40 and 60 years of age; women are affected + more than men by 2:1. + termDef: + term: >- + Somatostatin-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C3379 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3379" + term_id: C3379 + term_version: 20.05a + +"81563": + common: + description: >- + A malignant neuroendocrine tumor arising from delta cells which produce somatostatin. + It displays vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Somatostatinoma + source: NCIt + cde_id: C65190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65190" + term_id: C65190 + term_version: 20.05a + +"81581": + common: + description: >- + A hormone producing endocrine neoplasm, associated with a hormonal syndrome. + termDef: + term: >- + Functioning Endocrine Neoplasm + source: NCIt + cde_id: C94759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94759" + term_id: C94759 + term_version: 20.05a + +"81600": + common: + description: >- + A benign, well-demarcated polypoid neoplasm arising from the bile duct epithelium. + According to the growth pattern, it is classified as tubular, papillary, or + tubulopapillary. Adenomas arising from the extrahepatic bile ducts usually produce + symptoms related to biliary obstruction. + termDef: + term: >- + Bile Duct Adenoma + source: NCIt + cde_id: C2942 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2942" + term_id: C2942 + term_version: 20.05a + +"81603": + common: + description: >- + A carcinoma that arises from the intrahepatic bile ducts, the hepatic ducts, + or the common bile duct distal to the insertion of the cystic duct. The vast + majority of tumors are adenocarcinomas. + termDef: + term: >- + Cholangiocarcinoma + source: NCIt + cde_id: 'C4436 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4436 " + term_id: 'C4436 ' + term_version: 20.05a + +"81610": + common: + description: >- + An epithelial, usually multiloculated neoplasm arising from the intrahepatic + or extrahepatic bile ducts. It occurs predominantly in females. Signs and symptoms + include abdominal mass, abdominal pain, and jaundice. Morphologically, the cystic + spaces are lined by columnar epithelium and contain mucinous or serous fluid. + termDef: + term: >- + Bile Duct Mucinous Cystic Neoplasm + source: NCIt + cde_id: C4129 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4129" + term_id: C4129 + term_version: 20.05a + +"81613": + common: + description: >- + A mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic + bile ducts and it is associated with an invasive carcinomatous component. + termDef: + term: >- + Bile Duct Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma + source: NCIt + cde_id: C4130 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4130" + term_id: C4130 + term_version: 20.05a + +"81623": + common: + description: >- + A carcinoma that arises from the junction, or adjacent to the junction, of the + right and left hepatic ducts. + termDef: + term: >- + Hilar Cholangiocarcinoma + source: NCIt + cde_id: C36077 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36077" + term_id: C36077 + term_version: 20.05a + +"81630": + common: + description: >- + An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized + by the presence of low grade dysplasia. + termDef: + term: >- + Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with Low Grade Dysplasia + source: NCIt + cde_id: C95914 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95914" + term_id: C95914 + term_version: 20.05a + +"81632": + common: + description: >- + An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized + by the presence of high grade dysplasia. + termDef: + term: >- + Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade + Dysplasia + source: NCIt + cde_id: C95915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95915" + term_id: C95915 + term_version: 20.05a + +"81700": + common: + description: >- + A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears + as a soft, round mass which often contains areas of hemorrhage and necrosis. + Morphologically, the neoplastic cells resemble normal hepatocytes and form plates + separated by sinusoids. Most patients have a history of contraceptive or anabolic + steroids use. + termDef: + term: >- + Hepatocellular Adenoma + source: NCIt + cde_id: C3758 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3758" + term_id: C3758 + term_version: 20.05a + +"81703": + common: + description: >- + A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is + relatively rare in the United States but very common in all African countries + south of the Sahara and in Southeast Asia. Most cases are seen in patients over + the age of 50 years, but this tumor can also occur in younger individuals and + even in children. Hepatocellular carcinoma is more common in males than females + and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. + Serum elevation of alpha-fetoprotein occurs in a large percentage of patients + with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present + as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, + there is a wide range of differentiation from tumor to tumor (well differentiated + to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize + to regional lymph nodes and lung. The overall median survival of untreated liver + cell carcinoma is about 4 months. The most effective treatment of hepatocellular + carcinoma is complete resection of the tumor. Lately, an increasing number of + tumors have been treated with liver transplantation. + termDef: + term: >- + Hepatocellular Carcinoma + source: NCIt + cde_id: C3099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3099" + term_id: C3099 + term_version: 20.05a + +"81713": + common: + description: >- + A distinctive type of liver cell carcinoma that arises in non-cirrhotic livers + and is seen predominantly in young patients. The tumor cells are polygonal + and deeply eosinophilic, and are embedded in a fibrous stroma. The prognosis + is similar to classical hepatocellular carcinoma that arises in non-cirrhotic + livers, and better than hepatocellular carcinoma that arises in cirrhotic livers. + termDef: + term: >- + Fibrolamellar Carcinoma + source: NCIt + cde_id: C4131 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4131" + term_id: C4131 + term_version: 20.05a + +"81723": + common: + description: >- + An uncommon type of hepatocelluar carcinoma, morphologically characterized by + significant fibrosis around the sinusoid-like spaces and atrophy of the tumor + trabeculae. + termDef: + term: >- + Scirrhous Hepatocellular Carcinoma + source: NCIt + cde_id: C27388 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27388" + term_id: C27388 + term_version: 20.05a + +"81803": + common: + description: >- + A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma + that are intimately admixed. This tumor should be distinguished from separate + hepatocellular carcinoma and cholangiocarcinoma arising in the same liver. The + prognosis of this tumor is poor. + termDef: + term: >- + Combined Hepatocellular Carcinoma and Cholangiocarcinoma + source: NCIt + cde_id: C3828 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3828" + term_id: C3828 + term_version: 20.05a + +"81900": + common: + description: >- + A benign epithelial neoplasm characterized by the presence of a trabecular glandular + architectural pattern. + termDef: + term: >- + Trabecular Adenoma + source: NCIt + cde_id: C3688 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3688" + term_id: C3688 + term_version: 20.05a + +"81903": + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of a trabecular + glandular architectural pattern. + termDef: + term: >- + Trabecular Adenocarcinoma + source: NCIt + cde_id: C4068 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4068" + term_id: C4068 + term_version: 20.05a + +"82000": + common: + description: >- + A benign sweat gland neoplasm usually occurring in the scalp or the face. It + may present as solitary or multiple papular or nodular lesions. It may be a + sporadic lesion or part of Brooke-Spiegler syndrome. It arises from the dermis + and has a multinodular, circumscribed appearance. The nodules contain basaloid + cells with small, dark nuclei. Complete excision is usually curative. + termDef: + term: >- + Cylindroma + source: NCIt + cde_id: 'C27094 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27094 " + term_id: 'C27094 ' + term_version: 20.05a + +"82003": + common: + description: >- + A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic + epithelial cells form cylindrical spatial configurations (cribriform or classic + type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid + cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid + cystic carcinomas mostly occur in the salivary glands. Other primary sites + of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid + cystic carcinomas spread along nerve sheaths, resulting in severe pain, and + they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread + is characteristic. + termDef: + term: >- + Adenoid Cystic Carcinoma + source: NCIt + cde_id: C2970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2970" + term_id: C2970 + term_version: 20.05a + +"82012": + common: + description: >- + A ductal carcinoma in situ of the breast characterized by the presence of a + cribriform architectural pattern. + termDef: + term: >- + Intraductal Cribriform Breast Adenocarcinoma + source: NCIt + cde_id: C5138 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5138" + term_id: C5138 + term_version: 20.05a + +"82013": + common: + description: >- + A carcinoma characterized by the presence of a cribriform architectural pattern. + Representative examples include the intraductal cribriform breast carcinoma + and invasive cribriform breast carcinoma. + termDef: + term: >- + Cribriform Carcinoma + source: NCIt + cde_id: C3680 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3680" + term_id: C3680 + term_version: 20.05a + +"82020": + common: + description: >- + A benign epithelial neoplasm characterized by a microcystic pattern. The cystic + spaces are lined by small cuboidal cells without evidence of significant cytologic + atypia. + termDef: + term: >- + Microcystic Adenoma + source: NCIt + cde_id: C3685 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3685" + term_id: C3685 + term_version: 20.05a + +"82040": + common: + description: >- + A tubular type adenoma of the breast in which, during pregnancy and lactation, + the epithelial cells show extensive secretory changes. + termDef: + term: >- + Lactating Adenoma + source: NCIt + cde_id: C9473 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9473" + term_id: C9473 + term_version: 20.05a + +"82100": + common: + description: >- + A polypoid neoplasm arising from the glandular epithelium. There is proliferation + of glandular cells which may display dysplastic cytologic features. Representative + examples include the adenomatous polyps of the colon and rectum. + termDef: + term: >- + Adenomatous Polyp + source: NCIt + cde_id: C3764 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3764" + term_id: C3764 + term_version: 20.05a + +"82102": + common: + description: >- + A non-invasive adenocarcinoma arising from the neoplastic glandular cells in + an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma In Situ in Adenomatous Polyp + source: NCIt + cde_id: 'C7678 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7678 " + term_id: 'C7678 ' + term_version: 20.05a + +"82103": + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular + cells in an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma in Adenomatous Polyp + source: NCIt + cde_id: 'C7676 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7676 " + term_id: 'C7676 ' + term_version: 20.05a + +"82110": + common: + description: >- + A usually polypoid neoplasm arising from the glandular epithelium. It is characterized + by a tubular architectural pattern. The neoplastic glandular cells have dysplastic + features. Representative examples include the tubular adenomas of the colon + and rectum. + termDef: + term: >- + Tubular Adenoma + source: NCIt + cde_id: C4133 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4133" + term_id: C4133 + term_version: 20.05a + +"82113": + common: + description: >- + An infiltrating adenocarcinoma in which the malignant cells form tubular structures. + Representative examples include the tubular breast carcinoma and the gastric + tubular adenocarcinoma. + termDef: + term: >- + Tubular Adenocarcinoma + source: NCIt + cde_id: C65192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65192" + term_id: C65192 + term_version: 20.05a + +"82120": + common: + description: >- + An adenoma of the gastrointestinal tract mucosa which grossly and morphologically + does not appear as an elevated or polypoid lesion. + termDef: + term: >- + Flat Adenoma + source: NCIt + cde_id: C65193 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65193" + term_id: C65193 + term_version: 20.05a + +"82130": + common: + description: >- + An adenoma that arises from the large intestine and the appendix. It is characterized + by prominent serration of the glands and the presence of generalized low-grade + dysplasia. + termDef: + term: >- + Traditional Serrated Adenoma + source: NCIt + cde_id: 'C38458 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38458 " + term_id: 'C38458 ' + term_version: 20.05a + +"82143": + common: + description: >- + An adenocarcinoma of the stomach arising from the parietal cells. It is characterized + by the presence of malignant cells with eosinophilic, finely granular cytoplasm. + termDef: + term: >- + Gastric Parietal Cell Adenocarcinoma + source: NCIt + cde_id: C65194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65194" + term_id: C65194 + term_version: 20.05a + +"82153": + common: + description: >- + An anal adenocarcinoma arising from the epithelium of the anal glands. The + overlying anal mucosa does not show evidence of neoplastic changes. + termDef: + term: >- + Anal Glands Adenocarcinoma + source: NCIt + cde_id: C5609 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5609" + term_id: C5609 + term_version: 20.05a + +"82200": + common: + description: >- + An autosomal dominant disorder, characterized by the presence of multiple adenomas + in the colon and rectum. It is caused by a germline mutation in the adenomatous + polyposis coli (APC) gene which is located on the long arm of chromosome 5. + The adenomas are most often tubular, and they have the tendency to progress + to adenocarcinoma. They can occur throughout the colon, but they tend to concentrate + in the rectum and sigmoid colon. The colorectal adenomas are detected during + endoscopic examination between the age of 10 and 20 years. The adenomas increase + in size and numbers with age, and there is usually progression of one or more + adenomas to adenocarcinoma. The mean age of development of adenocarcinoma is + about 40 years. Signs include rectal bleeding and mucousy diarrhea. + termDef: + term: >- + Familial Adenomatous Polyposis + source: NCIt + cde_id: C3339 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3339" + term_id: C3339 + term_version: 20.05a + +"82203": + common: + description: >- + Adenocarcinomas developing in colorectal adenomas in patients with a history + of adenomatous polyposis coli. The mean age of development of adenocarcinoma + is about 40 years. + termDef: + term: >- + Adenocarcinoma in Adenomatous Polyposis Coli + source: NCIt + cde_id: C4134 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4134" + term_id: C4134 + term_version: 20.05a + +"82210": + common: + description: >- + A condition in which multiple adenomas develop in the gastrointestinal tract. + termDef: + term: >- + Multiple Adenomatous Polyps + source: NCIt + cde_id: C4135 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4135" + term_id: C4135 + term_version: 20.05a + +"82213": + common: + description: >- + Adenocarcinomas developing in gastrointestinal tract adenomas in patients with + multiple adenomatous polyps. + termDef: + term: >- + Adenocarcinoma in Multiple Adenomatous Polyps + source: NCIt + cde_id: C4136 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4136" + term_id: C4136 + term_version: 20.05a + +"82303": + common: + description: >- + A carcinoma morphologically characterized by the presence of solid sheets of + malignant epithelial cells in tissues. + termDef: + term: >- + Solid Carcinoma + source: NCIt + cde_id: C4137 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4137" + term_id: C4137 + term_version: 20.05a + +"82313": + common: + description: >- + An undifferentiated malignant epithelial neoplasm which tends to infiltrate + the surrounding tissues and spread to other anatomic sites. + termDef: + term: >- + Carcinoma Simplex + source: NCIt + cde_id: C65195 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65195" + term_id: C65195 + term_version: 20.05a + +"82401": + common: + description: >- + A carcinoid tumor that shows atypical characteristics and has borderline malignant + potential. + termDef: + term: >- + Carcinoid Tumor of Uncertain Malignant Potential + source: NCIt + cde_id: C65196 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65196" + term_id: C65196 + term_version: 20.05a + +"82403": + common: + description: >- + A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal + cells having monotonous, centrally located nuclei and small nucleoli, infrequent + mitoses, and no necrosis. The tumor may show a variety of patterns, such as + solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical + studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology + (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, + and mitoses) can occasionally be seen. Such cases may have an aggressive clinical + course. Gastrointestinal tract and lung are common sites of involvement. + termDef: + term: >- + Carcinoid Tumor + source: NCIt + cde_id: 'C2915 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2915 " + term_id: 'C2915 ' + term_version: 20.05a + +"82421": + common: + description: >- + A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) arising + from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like + type granules in the neoplastic cells. + termDef: + term: >- + Enterochromaffin-Like Cell Neuroendocrine Tumor G1 + source: NCIt + cde_id: C27252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27252" + term_id: C27252 + term_version: 20.05a + +"82423": + common: + description: >- + A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) arising + from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like + type granules in the neoplastic cells. + termDef: + term: >- + Enterochromaffin-Like Cell Neuroendocrine Tumor G1 + source: NCIt + cde_id: C27252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27252" + term_id: C27252 + term_version: 20.05a + +"82433": + common: + description: >- + A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells + with morphologic and immunohistochemical characteristics of carcinoid tumor + and malignant glandular cells. + termDef: + term: >- + Combined Carcinoid and Adenocarcinoma + source: NCIt + cde_id: C4139 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4139" + term_id: C4139 + term_version: 20.05a + +"82443": + common: + description: >- + A carcinoma that arises from the digestive system and is characterized by the + presence of a malignant glandular epithelial component and a malignant neuroendocrine + component. At least 30% of either component should be present for the diagnosis + to be made. + termDef: + term: >- + Digestive System Mixed Adenoneuroendocrine Carcinoma + source: NCIt + cde_id: C95406 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95406" + term_id: C95406 + term_version: 20.05a + +"82453": + common: + description: >- + A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells + with morphologic and immunohistochemical characteristics of carcinoid tumor + and malignant glandular cells. + termDef: + term: >- + Combined Carcinoid and Adenocarcinoma + source: NCIt + cde_id: C4139 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4139" + term_id: C4139 + term_version: 20.05a + +"82463": + common: + description: >- + A malignant neuroendocrine neoplasm composed of cells containing secretory granules + that stain positive for NSE and chromogranin. The neoplastic cells are often + round and form clusters or trabecular sheets. Representative examples are small + cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma. + termDef: + term: >- + Neuroendocrine Carcinoma + source: NCIt + cde_id: C3773 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3773" + term_id: C3773 + term_version: 20.05a + +"82473": + common: + description: >- + A rare malignant cutaneous tumor seen in elderly patients. Its usual location + is on the head, neck and extremities. The tumor is composed of small round cells + with scanty cytoplasm arranged in a trabecular pattern, or in ill-defined nodules + or in a diffuse pattern. The tumor cells contain cytoplasmic membrane-bound + dense core granules resembling neurosecretory granules. There is strong evidence + implicating Merkel cell polyomavirus in a majority of cases of Merkel cell carcinoma. + termDef: + term: >- + Merkel Cell Carcinoma + source: NCIt + cde_id: C9231 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9231" + term_id: C9231 + term_version: 20.05a + +"82481": + common: + description: >- + A tumor made up of cells with APUD properties. + termDef: + term: >- + Neoplasm of the Diffuse Neuroendocrine System + source: NCIt + cde_id: C2879 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2879" + term_id: C2879 + term_version: 20.05a + +"82493": + common: + description: >- + A carcinoid tumor characterized by a high mitotic rate, often associated with + the presence of necrosis and nuclear pleomorphism. + termDef: + term: >- + Atypical Carcinoid Tumor + source: NCIt + cde_id: 'C72074 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C72074 " + term_id: 'C72074 ' + term_version: 20.05a + +"82501": + common: + description: >- + This is a non-human neoplastic process described in sheep. + termDef: + term: >- + Pulmonary Adenomatosis + source: NCIt + cde_id: C3763 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3763" + term_id: C3763 + term_version: 20.05a + +"82502": + common: + description: >- + Lung adenocarcinoma in situ characterized by the presence of type II pneumocyte + and/or Clara cell differentiation. Almost all cases of lung adenocarcinoma in + situ are non-mucinous. + termDef: + term: >- + Lung Non-Mucinous Adenocarcinoma In Situ + source: NCIt + cde_id: C136716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C136716" + term_id: C136716 + term_version: 20.05a + +"82503": + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +"82510": + common: + description: >- + A benign, well circumscribed lung neoplasm morphologically characterized by + the presence of cystic spaces resembling alveoli, lined by a simple cuboidal + epithelium. The cystic spaces are surrounded by a spindle cell stroma which + may show myxoid changes. It is a solitary, usually peripheral lung lesion. Patients + are usually asymptomatic and its discovery is an incidental finding during chest + X-ray examination. Surgical excision is curative. + termDef: + term: >- + Alveolar Adenoma + source: NCIt + cde_id: C4140 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4140" + term_id: C4140 + term_version: 20.05a + +"82513": + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +"82523": + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by the presence of Clara cells and/or type II cells. + termDef: + term: >- + Minimally Invasive Lung Non-Mucinous Adenocarcinoma + source: NCIt + cde_id: C7269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7269" + term_id: C7269 + term_version: 20.05a + +"82533": + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by tall columnar cells and mucin production. + termDef: + term: >- + Minimally Invasive Lung Mucinous Adenocarcinoma + source: NCIt + cde_id: C7268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7268" + term_id: C7268 + term_version: 20.05a + +"82543": + common: + description: >- + A rare morphologic variant of bronchiolo-alveolar lung carcinoma characterized + by the presence of both mucin and non-mucin producing cells. + termDef: + term: >- + Mixed Mucinous and Non-Mucinous Bronchioloalveolar Carcinoma + source: NCIt + cde_id: C7270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7270" + term_id: C7270 + term_version: 20.05a + +"82553": + common: + description: >- + A lung adenocarcinoma consisting of a bronchioloalveolar component and an invasive + adenocarcinomatous component. + termDef: + term: >- + Lung Adenocarcinoma with Mixed Bronchioloalveolar and Invasive Components + source: NCIt + cde_id: C65197 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65197" + term_id: C65197 + term_version: 20.05a + +"82563": + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by the presence of Clara cells and/or type II cells. + termDef: + term: >- + Minimally Invasive Lung Non-Mucinous Adenocarcinoma + source: NCIt + cde_id: C7269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7269" + term_id: C7269 + term_version: 20.05a + +"82573": + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by tall columnar cells and mucin production. + termDef: + term: >- + Minimally Invasive Lung Mucinous Adenocarcinoma + source: NCIt + cde_id: C7268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7268" + term_id: C7268 + term_version: 20.05a + +"82600": + common: + description: >- + Glandular Papilloma + termDef: + term: >- + Glandular Papilloma + source: NCIt + cde_id: C6880 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6880" + term_id: C6880 + term_version: 20.05a + +"82603": + common: + description: >- + A morphologic variant of adenocarcinoma. It is characterized by the presence + of a papillary growth pattern. Representative examples include thyroid gland + papillary carcinoma, invasive papillary breast carcinoma, and ovarian serous + surface papillary adenocarcinoma. + termDef: + term: >- + Papillary Adenocarcinoma + source: NCIt + cde_id: 'C2853 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2853 " + term_id: 'C2853 ' + term_version: 20.05a + +"82610": + common: + description: >- + An epithelial neoplasm morphologically characterized by the presence of a villous + architectural pattern. Most often it occurs in the large intestine, small intestine, + and the stomach in which the neoplastic epithelial cells show dysplastic features. + It may also arise in the urinary bladder, urethra, and vagina. + termDef: + term: >- + Villous Adenoma + source: NCIt + cde_id: C7399 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7399" + term_id: C7399 + term_version: 20.05a + +"82612": + common: + description: >- + A non-invasive adenocarcinoma arising from a villous adenoma. + termDef: + term: >- + Adenocarcinoma In Situ in Villous Adenoma + source: NCIt + cde_id: C8376 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8376" + term_id: C8376 + term_version: 20.05a + +"82613": + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from a villous adenoma. + termDef: + term: >- + Adenocarcinoma in Villous Adenoma + source: NCIt + cde_id: C4141 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4141" + term_id: C4141 + term_version: 20.05a + +"82623": + common: + description: >- + An adenocarcinoma characterized by the presence of a villous architectural pattern. + It may arise from a villous adenoma. + termDef: + term: >- + Villous Adenocarcinoma + source: NCIt + cde_id: C4142 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4142" + term_id: C4142 + term_version: 20.05a + +"82630": + common: + description: >- + An epithelial neoplasm morphologically characterized by the presence of a villous + and a tubular architectural pattern. Most often it occurs in the large intestine, + small intestine, and the stomach in which the neoplastic epithelial cells show + dysplastic features. + termDef: + term: >- + Tubulovillous Adenoma + source: NCIt + cde_id: C4143 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4143" + term_id: C4143 + term_version: 20.05a + +"82632": + common: + description: >- + A non-invasive adenocarcinoma arising from a tubulovillous adenoma. + termDef: + term: >- + Adenocarcinoma In Situ in Tubulovillous Adenoma + source: NCIt + cde_id: C4144 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4144" + term_id: C4144 + term_version: 20.05a + +"82633": + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from a tubulovillous adenoma. + termDef: + term: >- + Adenocarcinoma in Tubulovillous Adenoma + source: NCIt + cde_id: C4145 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4145" + term_id: C4145 + term_version: 20.05a + +"82640": + common: + description: >- + Multifocal neoplastic proliferations of the glandular epithelium displaying + a papillary pattern. + termDef: + term: >- + Glandular Papillomatosis + source: NCIt + cde_id: 'C65198 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65198 " + term_id: 'C65198 ' + term_version: 20.05a + +"82700": + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells do not stain with acidic or basic dyes. + termDef: + term: >- + Pituitary Gland Chromophobe Adenoma + source: NCIt + cde_id: C2857 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2857" + term_id: C2857 + term_version: 20.05a + +"82703": + common: + description: >- + A type of carcinoma that comprises a minority of renal cell carcinomas. It + is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics + of the neoplastic cells, this type of carcinoma is classified as classic (typical) + or eosinophilic. It has a much better prognosis than other renal cell carcinomas. + termDef: + term: >- + Chromophobe Renal Cell Carcinoma + source: NCIt + cde_id: C4146 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4146" + term_id: C4146 + term_version: 20.05a + +"82710": + common: + description: >- + An adenoma of the anterior lobe of the pituitary gland that produces prolactin. It + is the most common type of pituitary gland adenomas and it is associated with + hyperprolactinemia. Clinical manifestations include amenorrhea, galactorrhea, + impotence, headache, and visual disturbances. + termDef: + term: >- + Lactotroph Adenoma + source: NCIt + cde_id: C3342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3342" + term_id: C3342 + term_version: 20.05a + +"82720": + common: + description: >- + A non-metastasizing tumor that arises from the adenohypophysial cells of the + anterior lobe of the pituitary gland. The tumor can be hormonally functioning + or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. + Due to its location in the sella turcica, expansion of the tumor mass can impinge + on the optic chiasm or involve the temporal lobe, third ventricle and posterior + fossa A frequently associated physical finding is bitemporal hemianopsia which + may progress to further visual loss. + termDef: + term: >- + Pituitary Gland Adenoma + source: NCIt + cde_id: C3329 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3329" + term_id: C3329 + term_version: 20.05a + +"82723": + common: + description: >- + A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial + cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The + majority are hormonally functioning neoplasms, usually producing prolactin or + ACTH. The diagnosis is based on the presence of metastases. Syndromes associated + with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, + and acromegaly. + termDef: + term: >- + Pituitary Gland Carcinoma + source: NCIt + cde_id: C4536 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4536" + term_id: C4536 + term_version: 20.05a + +"82800": + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells stain positive with acidic dyes. + termDef: + term: >- + Pituitary Gland Acidophil Adenoma + source: NCIt + cde_id: C6780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6780" + term_id: C6780 + term_version: 20.05a + +"82803": + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with acidic dyes. + termDef: + term: >- + Pituitary Gland Acidophil Carcinoma + source: NCIt + cde_id: C4147 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4147" + term_id: C4147 + term_version: 20.05a + +"82810": + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells stain positive with acidic and basic dyes. + termDef: + term: >- + Pituitary Gland Mixed Acidophil-Basophil Adenoma + source: NCIt + cde_id: C4148 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4148" + term_id: C4148 + term_version: 20.05a + +"82900": + common: + description: >- + A benign neoplasm composed of large cells with abundant eosinophilic granular + cytoplasm. Representative examples include oncocytic adenomas of the thyroid + gland, parathyroid gland, and pituitary gland. + termDef: + term: >- + Oncocytic Adenoma + source: NCIt + cde_id: 'C3759 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3759 " + term_id: 'C3759 ' + term_version: 20.05a + +"82903": + common: + description: >- + An adenocarcinoma characterized by the presence of large malignant epithelial + cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative + examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast + carcinoma, and salivary gland oncocytic carcinoma. + termDef: + term: >- + Oxyphilic Adenocarcinoma + source: NCIt + cde_id: C3679 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3679" + term_id: C3679 + term_version: 20.05a + +"83000": + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells stain positive with basic dyes. + termDef: + term: >- + Pituitary Gland Basophil Adenoma + source: NCIt + cde_id: C2856 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2856" + term_id: C2856 + term_version: 20.05a + +"83003": + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with basic dyes. + termDef: + term: >- + Basophilic Adenocarcinoma + source: NCIt + cde_id: C4150 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4150" + term_id: C4150 + term_version: 20.05a + +"83100": + common: + description: >- + A benign neoplasm composed of glands containing epithelial clear cells. + termDef: + term: >- + Clear Cell Adenoma + source: NCIt + cde_id: C4151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4151" + term_id: C4151 + term_version: 20.05a + +"83103": + common: + description: >- + A malignant neoplasm composed of glandular epithelial clear cells. Various + architectural patterns may be seen, including papillary, tubulocystic, and solid. + termDef: + term: >- + Clear Cell Adenocarcinoma + source: NCIt + cde_id: C3766 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3766" + term_id: C3766 + term_version: 20.05a + +"83113": + common: + description: >- + An autosomal dominant inherited syndrome caused by germline mutations in the + FH gene. It is characterized by predisposition to renal cell carcinoma, leiomyomas + of the skin and uterus, and leiomyosarcoma of the uterus. + termDef: + term: >- + Hereditary Leiomyomatosis and Renal Cell Carcinoma + source: NCIt + cde_id: C51302 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51302" + term_id: C51302 + term_version: 20.05a + +"83123": + common: + description: >- + A carcinoma arising from the renal parenchyma. There is a strong correlation + between cigarette smoking and the development of renal cell carcinoma. The + clinical presentation includes : hematuria, flank pain and a palpable lumbar + mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound + is performed for other purposes. Radical nephrectomy is the standard intervention + procedure. Renal cell carcinoma is generally considered to be resistant to + radiation treatment and chemotherapy. + termDef: + term: >- + Renal Cell Carcinoma + source: NCIt + cde_id: 'C9385 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9385 " + term_id: 'C9385 ' + term_version: 20.05a + +"83130": + common: + description: >- + A benign or borderline neoplasm characterized by the presence of glandular structures + which contain clear cells and a fibrotic stroma. + termDef: + term: >- + Clear Cell Adenofibroma + source: NCIt + cde_id: 'C8987 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8987 " + term_id: 'C8987 ' + term_version: 20.05a + +"83143": + common: + description: >- + A carcinoma characterized by the presence of malignant epithelial cells with + clear cytoplasm which contains neutral lipids. A representative example is the + lipid-rich breast carcinoma. + termDef: + term: >- + Lipid-Rich Carcinoma + source: NCIt + cde_id: C4152 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4152" + term_id: C4152 + term_version: 20.05a + +"83153": + common: + description: >- + A carcinoma characterized by the presence of malignant epithelial cells with + abundant clear cytoplasm which contains glycogen. A representative example is + the glycogen-rich, clear cell breast carcinoma. + termDef: + term: >- + Glycogen-Rich Carcinoma + source: NCIt + cde_id: C4153 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4153" + term_id: C4153 + term_version: 20.05a + +"83173": + common: + description: >- + A type of carcinoma that comprises a minority of renal cell carcinomas. It + is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics + of the neoplastic cells, this type of carcinoma is classified as classic (typical) + or eosinophilic. It has a much better prognosis than other renal cell carcinomas. + termDef: + term: >- + Chromophobe Renal Cell Carcinoma + source: NCIt + cde_id: C4146 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4146" + term_id: C4146 + term_version: 20.05a + +"83183": + common: + description: >- + A high grade carcinoma of the kidney. It is not a distinct clinicopathological + entity and includes a diverse group of renal cell carcinomas which have been + transformed from a lower to a higher grade. + termDef: + term: >- + Sarcomatoid Renal Cell Carcinoma + source: NCIt + cde_id: C27893 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27893" + term_id: C27893 + term_version: 20.05a + +"83193": + common: + description: >- + Also known as collecting duct carcinoma, this is a rare type of renal carcinoma. + It arises from the collecting ducts of the renal medulla, and most authors suggest + that this is an aggressive tumor. + termDef: + term: >- + Collecting Duct Carcinoma + source: NCIt + cde_id: C6194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6194" + term_id: C6194 + term_version: 20.05a + +"83203": + common: + description: >- + An adenocarcinoma characterized by the presence of malignant epithelial cells + with granular cytoplasm. + termDef: + term: >- + Granular Cell Carcinoma + source: NCIt + cde_id: C3681 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3681" + term_id: C3681 + term_version: 20.05a + +"83210": + common: + description: >- + A parathyroid gland adenoma composed predominantly of neoplastic chief cells. These + cells have either slightly eosinophilic or vacuolated cytoplasm, and round nuclei. + termDef: + term: >- + Parathyroid Gland Chief Cell Adenoma + source: NCIt + cde_id: C4154 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4154" + term_id: C4154 + term_version: 20.05a + +"83220": + common: + description: >- + A rare parathyroid gland adenoma composed of neoplastic cells with abundant + cytoplasm. The cytoplasm of the neoplastic cells is usually not entirely clear, + and is often variably vacuolated, foamy, and granular. + termDef: + term: >- + Parathyroid Gland Water-Clear Cell Adenoma + source: NCIt + cde_id: C4155 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4155" + term_id: C4155 + term_version: 20.05a + +"83223": + common: + description: >- + An adenocarcinoma characterized by the presence of malignant epithelial cells + with clear, often vacuolated or foamy cytoplasm. + termDef: + term: >- + Water-Clear Cell Adenocarcinoma + source: NCIt + cde_id: C4156 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4156" + term_id: C4156 + term_version: 20.05a + +"83230": + common: + description: >- + An adenoma characterized by the presence of a mixed epithelial cell population. + termDef: + term: >- + Mixed Cell Adenoma + source: NCIt + cde_id: C4157 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4157" + term_id: C4157 + term_version: 20.05a + +"83233": + common: + description: >- + An adenocarcinoma characterized by the presence of a mixed malignant glandular + cell population. + termDef: + term: >- + Mixed Cell Adenocarcinoma + source: NCIt + cde_id: C4158 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4158" + term_id: C4158 + term_version: 20.05a + +"83240": + common: + description: >- + An adenoma in which the neoplastic epithelial cells are admixed with adipose + tissue cells. + termDef: + term: >- + Lipoadenoma + source: NCIt + cde_id: C4159 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4159" + term_id: C4159 + term_version: 20.05a + +"83250": + common: + description: >- + A benign, well-circumscribed renal cortical neoplasm affecting females more + often than males. Polycythemia has been reported in twelve-percent of patients. + termDef: + term: >- + Metanephric Adenoma + source: NCIt + cde_id: C27253 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27253" + term_id: C27253 + term_version: 20.05a + +"83301": + common: + description: >- + An encapsulated or well-circumscribed tumor composed of well-differentiated + follicular cells with well-developed or partially developed nuclear features + of papillary thyroid carcinoma and with questionable capsular or vascular invasion. + That is this is a tumor indeterminate between follicular adenoma and follicular + carcinoma. Tumors in which vascular invasion has been excluded by all means + are called non-invasive follicular thyroid neoplasms with papillary-like nuclear + features. (WHO 2017) + termDef: + term: >- + Thyroid Gland Well-Differentiated Tumor of Uncertain Malignant Potential + source: NCIt + cde_id: C27729 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27729" + term_id: C27729 + term_version: 20.05a + +"83303": + common: + description: >- + A differentiated adenocarcinoma arising from the follicular cells of the thyroid + gland. The nuclear features which characterize the thyroid gland papillary + carcinoma are absent. Radiation exposure is a risk factor and it comprises + approximately 10% to 15% of thyroid cancers. Clinically, it usually presents + as a solitary mass in the thyroid gland. It is generally unifocal and thickly + encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures + include thyroid ultrasound and fine needle biopsy. + termDef: + term: >- + Thyroid Gland Follicular Carcinoma + source: NCIt + cde_id: C8054 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8054" + term_id: C8054 + term_version: 20.05a + +"83313": + common: + description: >- + A differentiated adenocarcinoma arising from the follicular cells of the thyroid + gland. The nuclear features which characterize the thyroid gland papillary + carcinoma are absent. Radiation exposure is a risk factor and it comprises + approximately 10% to 15% of thyroid cancers. Clinically, it usually presents + as a solitary mass in the thyroid gland. It is generally unifocal and thickly + encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures + include thyroid ultrasound and fine needle biopsy. + termDef: + term: >- + Thyroid Gland Follicular Carcinoma + source: NCIt + cde_id: C8054 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8054" + term_id: C8054 + term_version: 20.05a + +"83330": + common: + description: >- + A thyroid gland adenoma composed of microfollicular structures. + termDef: + term: >- + Thyroid Gland Microfollicular Adenoma + source: NCIt + cde_id: C4160 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4160" + term_id: C4160 + term_version: 20.05a + +"83340": + common: + description: >- + A thyroid gland adenoma composed of large size follicles. + termDef: + term: >- + Thyroid Gland Macrofollicular Adenoma + source: NCIt + cde_id: C4161 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4161" + term_id: C4161 + term_version: 20.05a + +"83360": + common: + description: >- + A rare, circumscribed or encapsulated tumor arising from the follicular cells + of the thyroid gland. It is characterized by a trabecular growth pattern and + hyalinized stroma formation. The vast majority of cases have a benign clinical + course. + termDef: + term: >- + Thyroid Gland Hyalinizing Trabecular Tumor + source: NCIt + cde_id: C6846 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6846" + term_id: C6846 + term_version: 20.05a + +"83373": + common: + description: >- + An adenocarcinoma arising from the thyroid gland showing only limited evidence + of follicular cell differentiation. Microscopically, the adenocarcinoma cells + are arranged in insular, solid, and trabecular patterns. There is associated + necrosis, and vascular invasion. The prognosis depends on the tumor stage, complete + or partial surgical removal of the tumor, and the degree of response to radioactive + iodine therapy. (adapted from WHO Tumors of Endocrine Organs, IARC Press, Lyon + 2004) + termDef: + term: >- + Poorly Differentiated Thyroid Gland Carcinoma + source: NCIt + cde_id: C6040 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6040" + term_id: C6040 + term_version: 20.05a + +"83393": + common: + description: >- + An encapsulated follicular carcinoma of the thyroid gland which shows angioinvasion. + termDef: + term: >- + Thyroid Gland Follicular Carcinoma, Encapsulated Angioinvasive + source: NCIt + cde_id: C156122 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156122" + term_id: C156122 + term_version: 20.05a + +"83403": + common: + description: >- + An encapsulated or nonencapsulated variant of papillary carcinoma of the thyroid + gland characterized by the predominance of follicular structures. The malignant + follicular cells display the nuclear features that characterize the papillary + adenocarcinomas of the thyroid gland. + termDef: + term: >- + Follicular Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: 'C126594 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126594 " + term_id: 'C126594 ' + term_version: 20.05a + +"83432": + common: + description: >- + A non-invasive neoplasm of thyroid follicular cells with a follicular growth + pattern and nuclear features of papillary thyroid carcinoma that has an extremely + low malignant potential. These tumors were formerly classified as non-invasive + encapsulated follicular variant of papillary thyroid carcinoma or well-differentiated + tumor of uncertain malignant potential. (WHO 2017) + termDef: + term: >- + Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear + Features + source: NCIt + cde_id: C126598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126598" + term_id: C126598 + term_version: 20.05a + +"83443": + common: + description: >- + A morphologic variant of papillary carcinoma of the thyroid gland characterized + by the presence of pseudostratified malignant follicular cells. + termDef: + term: >- + Columnar Cell Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: 'C35830 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35830 " + term_id: 'C35830 ' + term_version: 20.05a + +"83453": + common: + description: >- + A medullary thyroid gland carcinoma characterized by the presence of amyloid + stroma. The majority of medullary carcinomas of the thyroid gland are associated + with amyloid deposits. The latter are highlighted with Congo red staining method. + termDef: + term: >- + Thyroid Gland Medullary Carcinoma with Amyloid Stroma + source: NCIt + cde_id: 'C4193 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4193 " + term_id: 'C4193 ' + term_version: 20.05a + +"83503": + common: + description: >- + A morphologic variant of papillary carcinoma of the thyroid gland that more + often affects young patients and commonly metastasizing to the lungs. It is + characterized by a diffuse infiltration of the thyroid gland by malignant follicular + cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration. + termDef: + term: >- + Diffuse Sclerosing Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C7427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7427" + term_id: C7427 + term_version: 20.05a + +"83601": + common: + description: >- + An autosomal dominant inherited neoplastic syndrome characterized by the development + of various endocrine neoplasms and abnormalities in various anatomic sites. + There are four types recognized: type 1 (MEN 1), caused by inactivation of the + tumor suppressor gene MEN-1, type 2A (MEN 2A), caused by mutation of the RET + gene, type 2B (MEN 2B) also caused by mutation of the RET gene, and type 4 (MEN + 4) caused by mutation of the CDKN1B gene. Patients with MEN 1 may develop hyperparathyroidism + and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell + neoplasms, and carcinoid tumors. Patients with MEN 2A develop medullary thyroid + carcinomas and may also develop pheochromocytomas and parathyroid gland hyperplasia. + Patients with MEN 2B develop medullary thyroid carcinomas and numerous neural + defects including neuromas. Patients with MEN 4 develop endocrine neoplasms, + particularly in the parathyroid glands, pituitary, and pancreas. + termDef: + term: >- + Multiple Endocrine Neoplasia + source: NCIt + cde_id: C6432 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6432" + term_id: C6432 + term_version: 20.05a + +"83610": + common: + description: >- + A benign, well circumscribed neoplasm arising from the cortex of the kidney. + It secrets renin and the patients usually present with severe hypertension and + marked hypokalemia. Morphologically, it is characterized by the presence of + sheets of polygonal or spindle-shaped neoplastic cells forming a hemangiopericytic + pattern. + termDef: + term: >- + Juxtaglomerular Cell Tumor + source: NCIt + cde_id: C4162 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4162" + term_id: C4162 + term_version: 20.05a + +"83700": + common: + description: >- + A benign neoplasm that can arise from any of the adrenal cortical layers. It + can be associated with the overproduction of glucocorticoids (Cushing's syndrome), + androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids + (Conn's syndrome). (Sternberg Diagnostic Surgical Pathology, 3rd ed.) + termDef: + term: >- + Adrenal Cortex Adenoma + source: NCIt + cde_id: 'C9003 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9003 " + term_id: 'C9003 ' + term_version: 20.05a + +"83703": + common: + description: >- + A rare, usually large (greater than 5cm), malignant epithelial tumor arising + from the adrenal cortical cells. Symptoms are usually related to the excessive + production of hormones, and include Cushing's syndrome and virilism in women. Common + sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced + radiologic procedures have enabled the detection of small tumors, resulting + in the improvement of the 5-year survival. + termDef: + term: >- + Adrenal Cortex Carcinoma + source: NCIt + cde_id: 'C9325 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9325 " + term_id: 'C9325 ' + term_version: 20.05a + +"83710": + common: + description: >- + An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic + cytoplasm. + termDef: + term: >- + Adrenal Cortex Compact Cell Adenoma + source: NCIt + cde_id: C4163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4163" + term_id: C4163 + term_version: 20.05a + +"83720": + common: + description: >- + A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark + brown appearance and is characterized by the presence of neoplastic cells containing + abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome. + termDef: + term: >- + Pigmented Adrenal Cortex Adenoma + source: NCIt + cde_id: C4164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4164" + term_id: C4164 + term_version: 20.05a + +"83730": + common: + description: >- + An adenoma of the adrenal cortex composed of neoplastic clear cells containing + intracytoplasmic lipid droplets. + termDef: + term: >- + Adrenal Cortex Clear Cell Adenoma + source: NCIt + cde_id: C4165 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4165" + term_id: C4165 + term_version: 20.05a + +"83740": + common: + description: >- + An adenoma of the adrenal cortex composed of neoplastic cells with cytologic + features of glomerulosa cells. + termDef: + term: >- + Adrenal Cortex Glomerulosa Cell Adenoma + source: NCIt + cde_id: C4166 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4166" + term_id: C4166 + term_version: 20.05a + +"83750": + common: + description: >- + An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, + including varying numbers of neoplastic clear and compact cells. + termDef: + term: >- + Adrenal Cortex Mixed Cell Adenoma + source: NCIt + cde_id: C4167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4167" + term_id: C4167 + term_version: 20.05a + +"83801": + common: + description: >- + An epithelial neoplasm that arises from the ovary characterized by the presence + of glandular or cystic spaces which contain atypical glandular epithelial cells + resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. + There is no evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid + Tumor + source: NCIt + cde_id: C7983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7983" + term_id: C7983 + term_version: 20.05a + +"83802": + common: + description: >- + An endometrial hyperplasia characterized by cytologic and architectural changes + which may lead to endometrial carcinoma. Despite the atypical features and + possible course, there is debate on whether to consider this a neoplasm. The + relationship with endometrial intraepithelial neoplasia is also unclear. + termDef: + term: >- + Atypical Endometrial Hyperplasia + source: NCIt + cde_id: C4654 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4654" + term_id: C4654 + term_version: 20.05a + +"83803": + common: + description: >- + An adenocarcinoma characterized by the presence of malignant glandular epithelial + cells resembling endometrial cells. It can arise from the uterine body, ovary, + fallopian tube, cervix, vagina, and uterine ligament. + termDef: + term: >- + Endometrioid Adenocarcinoma + source: NCIt + cde_id: C3769 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3769" + term_id: C3769 + term_version: 20.05a + +"83810": + common: + description: >- + A benign neoplasm of the ovary characterized by the presence of glandular structures + with endometrial-type well-differentiated cells in a fibrotic stroma. + termDef: + term: >- + Ovarian Endometrioid Adenofibroma + source: NCIt + cde_id: 'C27287 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27287 " + term_id: 'C27287 ' + term_version: 20.05a + +"83811": + common: + description: >- + An epithelial neoplasm that arises from the ovary characterized by the presence + of glandular or cystic spaces which contain atypical glandular epithelial cells + resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. + There is no evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid + Tumor + source: NCIt + cde_id: C7983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7983" + term_id: C7983 + term_version: 20.05a + +"83823": + common: + description: >- + An endometrioid adenocarcinoma arising from the endometrium. Morphologically + it is characterized by the presence of malignant glandular cells containing + glycogen vacuoles which are usually subnuclear and reminiscent of early secretory + endometrium. + termDef: + term: >- + Endometrial Endometrioid Adenocarcinoma, Secretory Variant + source: NCIt + cde_id: C27839 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27839" + term_id: C27839 + term_version: 20.05a + +"83833": + common: + description: >- + An endometrioid adenocarcinoma arising from the endometrium, in which ciliated + cells line the majority of the malignant glands. + termDef: + term: >- + Endometrial Endometrioid Adenocarcinoma, Ciliated Variant + source: NCIt + cde_id: C27848 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27848" + term_id: C27848 + term_version: 20.05a + +"83843": + common: + description: >- + An adenocarcinoma characterized by the presence of malignant glandular epithelium + resembling the endocervical epithelium. + termDef: + term: >- + Adenocarcinoma, Endocervical Type + source: NCIt + cde_id: C66951 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66951" + term_id: C66951 + term_version: 20.05a + +"83900": + common: + description: >- + A benign epithelial neoplasm arising from the sebaceous or sweat glands. Representative + examples include sebaceous adenoma, tubular apocrine adenoma, and hidradenoma. + termDef: + term: >- + Skin Appendage Adenoma + source: NCIt + cde_id: 'C7580 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7580 " + term_id: 'C7580 ' + term_version: 20.05a + +"83903": + common: + description: >- + A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. + Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine + carcinoma, and pilomatrical carcinoma. + termDef: + term: >- + Adnexal Carcinoma + source: NCIt + cde_id: C3775 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3775" + term_id: C3775 + term_version: 20.05a + +"83910": + common: + description: >- + A rare, pilar-associated mesenchyme neoplasm with follicular differentiation. + It usually occurs in the face, neck, and chest. It presents as a dome-shaped + papular lesion. It is composed of epithelial and mesenchymal cells. Patients + with Birt-Hogg-Dube syndrome may develop follicular fibromas. + termDef: + term: >- + Fibrofolliculoma + source: NCIt + cde_id: 'C43331 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43331 " + term_id: 'C43331 ' + term_version: 20.05a + +"83920": + common: + description: >- + A rare, benign eccrine neoplasm usually arising on acral areas as a solitary + papular or nodular lesion. Multiple lesions are referred as syringofibroadenomatosis. + It is characterized by the presence of epithelial cuboidal cells forming anastomosing + cords in a fibrovascular stroma. + termDef: + term: >- + Syringofibroadenoma + source: NCIt + cde_id: C43356 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43356" + term_id: C43356 + term_version: 20.05a + +"84000": + common: + description: >- + A benign epithelial neoplasm arising from the sweat glands. Representative examples + include tubular apocrine adenoma, syringofibroadenoma, and hidradenoma. + termDef: + term: >- + Sweat Gland Adenoma + source: NCIt + cde_id: 'C7560 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7560 " + term_id: 'C7560 ' + term_version: 20.05a + +"84001": + common: + description: >- + A benign or malignant neoplasm arising from the sweat glands. + termDef: + term: >- + Sweat Gland Neoplasm + source: NCIt + cde_id: C3398 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3398" + term_id: C3398 + term_version: 20.05a + +"84003": + common: + description: >- + A carcinoma arising from the sweat glands. Representative examples include tubular + carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine + carcinoma. + termDef: + term: >- + Sweat Gland Carcinoma + source: NCIt + cde_id: 'C6938 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6938 " + term_id: 'C6938 ' + term_version: 20.05a + +"84010": + common: + description: >- + A benign epithelial neoplasm arising from the apocrine sweat glands. Representative + examples include tubular apocrine adenoma and external auditory canal ceruminous + adenoma. + termDef: + term: >- + Apocrine Adenoma + source: NCIt + cde_id: 'C4168 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4168 " + term_id: 'C4168 ' + term_version: 20.05a + +"84020": + common: + description: >- + A benign epithelial neoplasm arising from the sweat glands. It presents as a + nodular lesion usually in the scalp, trunk, and proximal extremities. It is + characterized by a nodular growth pattern. Complete excision is curative. + termDef: + term: >- + Nodular Hidradenoma + source: NCIt + cde_id: 'C7568 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7568 " + term_id: 'C7568 ' + term_version: 20.05a + +"84023": + common: + description: >- + A carcinoma with apocrine and less often eccrine differentiation, arising from + the sweat glands. It usually presents as a solitary slow growing nodule in the + dermis or subcutaneous tissues. It is characterized by a nodular growth pattern + and it is often associated with necrotic changes. + termDef: + term: >- + Hidradenocarcinoma + source: NCIt + cde_id: C54664 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54664" + term_id: C54664 + term_version: 20.05a + +"84030": + common: + description: >- + A benign epithelial neoplasm with eccrine or apocrine differentiation, arising + from the sweat glands. It usually presents as a solitary, well circumscribed, + firm nodule in the face and upper trunk. It is characterized by the presence + of basaloid cells forming nodules in the dermis. Cases of carcinoma arising + from long standing spiradenomas have been reported. + termDef: + term: >- + Spiradenoma + source: NCIt + cde_id: C4170 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4170" + term_id: C4170 + term_version: 20.05a + +"84033": + common: + description: >- + A very rare, aggressive carcinoma of the sweat glands arising from malignant + transformation of a long standing spiradenoma. It usually grows in the upper + extremities, lower extremities, trunk, and head and neck. It has the tendency + to recur and metastasize most often to the lymph nodes, bones, and lungs. + termDef: + term: >- + Spiradenocarcinoma + source: NCIt + cde_id: C5117 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5117" + term_id: C5117 + term_version: 20.05a + +"84040": + common: + description: >- + A benign cystic proliferation of the sweat glands with apocrine or eccrine differentiation. + It usually presents as a dome-shaped, cystic papular or nodular lesion usually + in the face and neck. It is a unilocular or mutlilocular lesion lined by an + inner and an outer layer of epithelium. Complete excision is usually curative. + termDef: + term: >- + Hidrocystoma + source: NCIt + cde_id: 'C3760 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3760 " + term_id: 'C3760 ' + term_version: 20.05a + +"84050": + common: + description: >- + A benign neoplasm arising from the sweat glands. It presents as a slow growing + cystic nodular lesion most often in the skin of the vulva and the perianal region. + It is characterized by the presence of cystic and large papillary structures. + The papillary structures contain connective tissue and are covered by two layers + of epithelium. Complete excision is curative. + termDef: + term: >- + Hidradenoma Papilliferum + source: NCIt + cde_id: C4171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4171" + term_id: C4171 + term_version: 20.05a + +"84060": + common: + description: >- + A benign adnexal neoplasm occurring during childhood or adolescence. It usually + presents as a papular lesion or a plaque on the head and neck. It may arise + in an organoid nevus such as sebaceous. It is characterized by an endophytic + invagination of the epithelium into the dermis. There are dermal cystic spaces + present, containing villous projections. Complete excision is curative. + termDef: + term: >- + Syringocystadenoma Papilliferum + source: NCIt + cde_id: C4172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4172" + term_id: C4172 + term_version: 20.05a + +"84070": + common: + description: >- + A benign sweat gland neoplasm usually affecting the lower eyelids and upper + cheeks. The lesions are papular and are usually numerous. Morphologically, there + are nests, cords, and tubules of epithelial cells present, surrounded by a dense + stroma in the reticular dermis. + termDef: + term: >- + Syringoma + source: NCIt + cde_id: C3761 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3761" + term_id: C3761 + term_version: 20.05a + +"84073": + common: + description: >- + A low grade adenocarcinoma with ductal differentiation, arising from the sweat + glands. It presents as a scar usually in the face. It is characterized by the + formation of small ducts and it frequently involves nerves and perineural spaces. + termDef: + term: >- + Microcystic Adnexal Carcinoma + source: NCIt + cde_id: C7581 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7581" + term_id: C7581 + term_version: 20.05a + +"84080": + common: + description: >- + A benign neoplasm arising from the sweat glands. It is characterized by the + presence of eccrine ducts in the dermis containing intraluminal papillary projections. + termDef: + term: >- + Papillary Eccrine Adenoma + source: NCIt + cde_id: C4173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4173" + term_id: C4173 + term_version: 20.05a + +"84083": + common: + description: >- + An adenocarcinoma arising from the sweat glands. Most cases present as nodular + lesions on the digits, usually in the hands. It is characterized by the presence + of epithelial cells in the dermis forming nodules. Cystic structures containing + papillary projections are also present. It may recur and metastasize, most commonly + to the lungs. + termDef: + term: >- + Digital Papillary Adenocarcinoma + source: NCIt + cde_id: C27534 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27534" + term_id: C27534 + term_version: 20.05a + +"84090": + common: + description: >- + A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. + It usually presents as a solitary, dome-shaped papule, nodule, or plaque on + acral sites. It is characterized by a proliferation of uniform basaloid cells + in the dermis and it is associated with the presence of focal ductal and cystic + structures. Complete excision is curative. + termDef: + term: >- + Poroma + source: NCIt + cde_id: C27273 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27273" + term_id: C27273 + term_version: 20.05a + +"84093": + common: + description: >- + A carcinoma with eccrine differentiation arising from the sweat glands. It may + arise de novo or as a malignant transformation of a pre-existing poroma. It + usually grows in the legs, buttocks, feet, and trunk and usually presents as + an ulcerative plaque. It is characterized by the presence of intraepidermal + and dermal nests of malignant epithelial cells. It may recur after excision + and metastasize to the lymph nodes and less frequently to distal anatomic sites. + termDef: + term: >- + Porocarcinoma + source: NCIt + cde_id: C5560 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5560" + term_id: C5560 + term_version: 20.05a + +"84100": + common: + description: >- + A benign, well circumscribed neoplasm arising from the sebaceous glands. It + usually presents as a small yellowish tumor in the sun exposed skin of head + and neck. It is characterized by the presence of sebaceous cells aggregates + with a peripheral rim of basaloid cells. + termDef: + term: >- + Sebaceous Adenoma + source: NCIt + cde_id: 'C4174 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4174 " + term_id: 'C4174 ' + term_version: 20.05a + +"84103": + common: + description: >- + An adenocarcinoma with sebaceous differentiation. It presents as a painless + mass and it may be multifocal. It grows in the ocular adnexae and in the skin + of head and neck, trunk, genitals, and extremities. It is characterized by the + presence of malignant cells with multivesicular and clear cytoplasm. It may + recur and metastasize. + termDef: + term: >- + Sebaceous Carcinoma + source: NCIt + cde_id: C40310 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40310" + term_id: C40310 + term_version: 20.05a + +"84200": + common: + description: >- + A benign epithelial neoplasm derived from ceruminous glands in the external + auditory canal. It presents as a grey mass covered by skin. It is characterized + by a proliferation of glands composed of cells with abundant eosinophilic and + granular cytoplasm. + termDef: + term: >- + External Auditory Canal Ceruminous Adenoma + source: NCIt + cde_id: C6088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6088" + term_id: C6088 + term_version: 20.05a + +"84203": + common: + description: >- + An infiltrating adenocarcinoma derived from ceruminous glands in the external + auditory canal. + termDef: + term: >- + Ceruminous Adenocarcinoma + source: NCIt + cde_id: C4176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4176" + term_id: C4176 + term_version: 20.05a + +"84303": + common: + description: >- + A carcinoma morphologically characterized the presence of cuboidal mucous cells, + goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal + formation. It can occur in several anatomic sites, including parotid gland, + oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. + It is classified as low or high grade. + termDef: + term: >- + Mucoepidermoid Carcinoma + source: NCIt + cde_id: C3772 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3772" + term_id: C3772 + term_version: 20.05a + +"84400": + common: + description: >- + A benign or borderline cystic epithelial neoplasm arising from the glandular + epithelium. The epithelial cells line the cystic spaces which contain serous + or mucinous fluid. Representative examples include ovarian and pancreatic cystadenomas. + termDef: + term: >- + Cystadenoma + source: NCIt + cde_id: C2972 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2972" + term_id: C2972 + term_version: 20.05a + +"84403": + common: + description: >- + A malignant cystic epithelial neoplasm arising from the glandular epithelium. The + malignant epithelial cells invade the stroma. The cystic spaces contain serous + or mucinous fluid. Representative examples include ovarian and pancreatic cystadenocarcinomas. + termDef: + term: >- + Cystadenocarcinoma + source: NCIt + cde_id: C2971 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2971" + term_id: C2971 + term_version: 20.05a + +"84410": + common: + description: >- + A serous neoplasm in which the cysts and papillae are lined by a single layer + of cells without atypia, architectural complexity or invasion. + termDef: + term: >- + Serous Cystadenoma + source: NCIt + cde_id: C3783 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3783" + term_id: C3783 + term_version: 20.05a + +"84412": + common: + description: >- + A non-invasive serous carcinoma arising from the fallopian tube. + termDef: + term: >- + Serous Tubal Intraepithelial Carcinoma + source: NCIt + cde_id: C126449 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126449" + term_id: C126449 + term_version: 20.05a + +"84413": + common: + description: >- + A malignant serous cystic neoplasm usually involving the ovary or the pancreas. + It is characterized by the presence of invasive malignant glandular epithelial + cells which often form papillary structures. + termDef: + term: >- + Serous Cystadenocarcinoma + source: NCIt + cde_id: C3778 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3778" + term_id: C3778 + term_version: 20.05a + +"84421": + common: + description: >- + A serous cystic glandular epithelial neoplasm of low malignant potential. It + is characterized by the presence of atypical or malignant glandular epithelial + cells with an absence of stromal invasion. + termDef: + term: >- + Borderline Serous Cystadenoma + source: NCIt + cde_id: C4177 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4177" + term_id: C4177 + term_version: 20.05a + +"84500": + common: + description: >- + A serous or mucinous benign or low malignant potential cystic epithelial neoplasm. + It is characterized by the presence of glandular epithelial cells forming papillary + structures. + termDef: + term: >- + Papillary Cystadenoma + source: NCIt + cde_id: C2974 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2974" + term_id: C2974 + term_version: 20.05a + +"84503": + common: + description: >- + A malignant cystic serous or mucinous epithelial neoplasm characterized by the + presence of malignant glandular epithelial cells forming papillary structures. + Stromal invasion is present. + termDef: + term: >- + Papillary Cystadenocarcinoma + source: NCIt + cde_id: C3777 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3777" + term_id: C3777 + term_version: 20.05a + +"84511": + common: + description: >- + A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. + It is characterized by the presence of atypical or malignant glandular epithelial + cells forming papillary structures with an absence of stromal invasion. + termDef: + term: >- + Borderline Papillary Cystadenoma + source: NCIt + cde_id: C4178 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4178" + term_id: C4178 + term_version: 20.05a + +"84521": + common: + description: >- + A benign, malignant, or borderline epithelial neoplasm characterized by the + presence of papillary mucinous, serous, or clear cell structures and cystic + structures. + termDef: + term: >- + Papillary Cystic Neoplasm + source: NCIt + cde_id: C4179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4179" + term_id: C4179 + term_version: 20.05a + +"84532": + common: + description: >- + A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized + by the presence of neoplastic epithelial cells that exhibit loss of polarity, + nuclear stratification, hyperchromasia, and pleomorphism. There is severe architectural + atypia and frequent mitotic figures present. + termDef: + term: >- + Pancreatic Intraductal Papillary-Mucinous Neoplasm with High Grade Dysplasia + source: NCIt + cde_id: C41251 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C41251" + term_id: C41251 + term_version: 20.05a + +"84540": + common: + description: >- + A multicystic tumor arising in the inferior interatrial septum in the region + of the atrioventricular node. The vast majority of patients present with complete + heart block and a minority with partial heart block. Sudden death is reported + in approximately 10% of the cases. It is a morphologically benign tumor composed + of cuboidal, transitional, or squamoid cells. The cells may also show sebaceous + differentiation and originate from the endoderm. + termDef: + term: >- + Cystic Tumor of the Atrioventricular Node + source: NCIt + cde_id: C45754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45754" + term_id: C45754 + term_version: 20.05a + +"84600": + common: + description: >- + A serous benign or low malignant potential cystic epithelial neoplasm characterized + by the presence of glandular epithelial cells forming papillary structures. + termDef: + term: >- + Papillary Serous Cystadenoma + source: NCIt + cde_id: C4180 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4180" + term_id: C4180 + term_version: 20.05a + +"84602": + common: + description: >- + A non-invasive serous neoplasm that arises from the ovary and shows micropapillary + and/or cribriform architectural patterns. It is composed of round epithelial + cells with scant cytoplasm and moderate nuclear atypia. + termDef: + term: >- + Borderline Ovarian Serous Tumor-Micropapillary Variant/Non-Invasive Low Grade + Ovarian Serous Carcinoma + source: NCIt + cde_id: C122585 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122585" + term_id: C122585 + term_version: 20.05a + +"84603": + common: + description: >- + A malignant cystic serous epithelial neoplasm characterized by the presence + of malignant glandular epithelial cells forming papillary structures. Stromal + invasion is present. + termDef: + term: >- + Papillary Serous Cystadenocarcinoma + source: NCIt + cde_id: 'C8377 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8377 " + term_id: 'C8377 ' + term_version: 20.05a + +"84610": + common: + description: >- + A non-invasive papillary serous epithelial neoplasm usually arising from the + ovary. + termDef: + term: >- + Serous Surface Papilloma + source: NCIt + cde_id: C4181 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4181" + term_id: C4181 + term_version: 20.05a + +"84613": + common: + description: >- + An invasive serous adenocarcinoma arising from the ovary and rarely the peritoneum. + Morphologically, it may be a well, moderately, or poorly differentiated neoplasm. + It is characterized by a papillary growth pattern often associated with the + presence of psammoma bodies. + termDef: + term: >- + Serous Surface Papillary Carcinoma + source: NCIt + cde_id: 'C4182 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4182 " + term_id: 'C4182 ' + term_version: 20.05a + +"84621": + common: + description: >- + A low malignant potential cystic serous epithelial neoplasm arising from the + ovary. Cases with identical morphology have been described arising from the + peritoneum as well. It is characterized by an atypical epithelial proliferation + and a papillary growth pattern. There is no evidence of destructive stromal + invasion. + termDef: + term: >- + Borderline Papillary Serous Cystadenoma + source: NCIt + cde_id: C4183 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4183" + term_id: C4183 + term_version: 20.05a + +"84700": + common: + description: >- + A benign or low malignant potential cystic epithelial neoplasm composed of cells + which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, + appendix, and lung. + termDef: + term: >- + Mucinous Cystadenoma + source: NCIt + cde_id: 'C2973 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2973 " + term_id: 'C2973 ' + term_version: 20.05a + +"84703": + common: + description: >- + An invasive adenocarcinoma characterized by cystic changes and the presence + of malignant glandular cells which contain intracytoplasmic mucin. It may arise + from the ovary, pancreas, appendix, and lung. + termDef: + term: >- + Mucinous Cystadenocarcinoma + source: NCIt + cde_id: C3776 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3776" + term_id: C3776 + term_version: 20.05a + +"84710": + common: + description: >- + A usually benign and less often low malignant potential cystic epithelial neoplasm + composed of cells which contain intracytoplasmic mucin. It is characterized + by the presence of papillary structures. + termDef: + term: >- + Papillary Mucinous Cystadenoma + source: NCIt + cde_id: C4184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4184" + term_id: C4184 + term_version: 20.05a + +"84713": + common: + description: >- + An invasive adenocarcinoma characterized by cystic changes, papillary growth + pattern, and the presence of malignant glandular cells which contain intracytoplasmic + mucin. + termDef: + term: >- + Papillary Mucinous Cystadenocarcinoma + source: NCIt + cde_id: C65204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65204" + term_id: C65204 + term_version: 20.05a + +"84721": + common: + description: >- + A morphologic variant of lung adenocarcinoma characterized by the presence of + mucin pools containing islands of well differentiated adenocarcinoma cells. + termDef: + term: >- + Lung Colloid Adenocarcinoma + source: NCIt + cde_id: C45512 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45512" + term_id: C45512 + term_version: 20.05a + +"84731": + common: + description: >- + A low malignant potential cystic epithelial neoplasm usually arising from the + ovary. It is composed of glandular cells with intracytoplasmic mucin. It is + characterized by an atypical epithelial proliferation and a papillary growth + pattern. There is no evidence of destructive stromal invasion. + termDef: + term: >- + Borderline Papillary Mucinous Cystadenoma + source: NCIt + cde_id: C4186 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4186" + term_id: C4186 + term_version: 20.05a + +"84741": + common: + description: >- + A low grade, non-invasive mixed epithelial proliferative neoplasm that arises + from the ovary. It is composed predominantly of serous and endocervical-type + mucinous cells. + termDef: + term: >- + Borderline Ovarian Seromucinous Tumor/Atypical Proliferative Ovarian Seromucinous + Tumor + source: NCIt + cde_id: C7281 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7281" + term_id: C7281 + term_version: 20.05a + +"84743": + common: + description: >- + A malignant mixed epithelial neoplasm that arises from the ovary and is composed + predominantly of serous and endocervical-type mucinous epithelium. + termDef: + term: >- + Ovarian Seromucinous Carcinoma + source: NCIt + cde_id: C40090 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40090" + term_id: C40090 + term_version: 20.05a + +"84800": + common: + description: >- + A benign or low malignant potential cystic epithelial neoplasm composed of cells + which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, + appendix, and lung. + termDef: + term: >- + Mucinous Cystadenoma + source: NCIt + cde_id: C2973 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2973" + term_id: C2973 + term_version: 20.05a + +"84801": + common: + description: >- + A well differentiated mucinous adenocarcinoma that arises from the appendix. It + is characterized by slow growth and it is associated with the development of + pseudomyxoma peritonei. Unlike the high grade mucinous adenocarcinoma of the + appendix, it usually does not spread beyond the peritoneum and it does not metastasize + to distant anatomic sites. + termDef: + term: >- + Low-Grade Appendix Mucinous Neoplasm + source: NCIt + cde_id: C42598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C42598" + term_id: C42598 + term_version: 20.05a + +"84803": + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +"84806": + common: + description: >- + A usually well differentiated mucinous adenocarcinoma of the peritoneum. The + majority of cases represent tumor spread from a primary low grade mucinous neoplasm + of the appendix. Cases of pseudomyxoma peritonei associated with mucinous adenocarcinomas + of the gallbladder, stomach, colon, rectum, pancreas, lung, breast, and fallopian + tubes have also been reported. In the past, the ovary has been considered as + a common primary site associated with pseudomyxoma peritonei. However, there + is recent evidence based on immunohistochemistry and molecular genetic analysis + suggesting that most cases of pseudomyxoma peritonei probably represent metastasis + from an appendiceal and not ovarian primary. + termDef: + term: >- + Pseudomyxoma Peritonei + source: NCIt + cde_id: C3345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3345" + term_id: C3345 + term_version: 20.05a + +"84813": + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which produce + mucin. + termDef: + term: >- + Mucin-Producing Adenocarcinoma + source: NCIt + cde_id: 'C27379 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27379 " + term_id: 'C27379 ' + term_version: 20.05a + +"84823": + common: + description: >- + A mucinous adenocarcinoma characterized by the presence of malignant glandular + cells which resemble the endocervical epithelium. + termDef: + term: >- + Mucinous Adenocarcinoma, Endocervical Type + source: NCIt + cde_id: C66953 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66953" + term_id: C66953 + term_version: 20.05a + +"84903": + common: + description: >- + A usually aggressive, poorly differentiated invasive adenocarcinoma characterized + by the presence of malignant glandular cells in which the nucleus is pressed + to one side by the presence of intracytoplasmic mucus. It may arise from the + stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, + pancreas, lung, bladder, breast, and prostate gland. + termDef: + term: >- + Signet Ring Cell Carcinoma + source: NCIt + cde_id: 'C3774 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3774 " + term_id: 'C3774 ' + term_version: 20.05a + +"84906": + common: + description: >- + A signet ring cell carcinoma that has spread from its original site of growth + to another anatomic site. + termDef: + term: >- + Metastatic Signet Ring Cell Carcinoma + source: NCIt + cde_id: 'C66717 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66717 " + term_id: 'C66717 ' + term_version: 20.05a + +"85002": + common: + description: >- + A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There + is no evidence of invasion of the basement membrane. Currently, it is classified + into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade + DCIS. In this classification the DCIS grade is defined by a combination of nuclear + grade, architectural growth pattern and presence of necrosis. The size of the + lesion as well as the grade and the clearance margins play a major role in dictating + the most appropriate therapy for DCIS. + termDef: + term: >- + Ductal Breast Carcinoma In Situ + source: NCIt + cde_id: 'C2924 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2924 " + term_id: 'C2924 ' + term_version: 20.05a + +"85003": + common: + description: >- + The most common type of invasive breast carcinoma, accounting for approximately + 70% of breast carcinomas. The gross appearance is usually typical with an irregular + stellate outline. Microscopically, randomly arranged epithelial elements are + seen. When large sheets of malignant cells are present, necrosis may be seen. With + adequate tissue sampling, in situ carcinoma can be demonstrated in association + with the infiltrating carcinoma. The in situ component is nearly always ductal + but occasionally may be lobular or both. + termDef: + term: >- + Invasive Ductal Carcinoma, Not Otherwise Specified + source: NCIt + cde_id: 'C4194 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4194 " + term_id: 'C4194 ' + term_version: 20.05a + +"85013": + common: + description: >- + A high grade carcinoma characterized by the presence of comedo-type tumor cell + necrosis in which the necrotic areas are surrounded by a solid proliferation + of malignant pleomorphic cells. + termDef: + term: >- + Comedocarcinoma + source: NCIt + cde_id: C4188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4188" + term_id: C4188 + term_version: 20.05a + +"85023": + common: + description: >- + A rare, low grade invasive adenocarcinoma of the breast characterized by the + presence of cells that secrete milk-like material. Morphologically, it usually + appears as a circumscribed lesion, composed of cystic spaces, tubular structures, + and solid areas. + termDef: + term: >- + Secretory Breast Carcinoma + source: NCIt + cde_id: C4189 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4189" + term_id: C4189 + term_version: 20.05a + +"85030": + common: + description: >- + An intraluminal papillary epithelial neoplasm arising within the ducts. Representative + examples are the intraductal breast papilloma and the salivary gland intraductal + papilloma. + termDef: + term: >- + Intraductal Papilloma + source: NCIt + cde_id: 'C3785 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3785 " + term_id: 'C3785 ' + term_version: 20.05a + +"85032": + common: + description: >- + A non-invasive breast adenocarcinoma located in a distended duct. It is characterized + by the presence of papillary structures with fibrovascular stalks. In the absence + of ductal carcinoma in situ or invasive carcinoma in adjacent tissues, the prognosis + is usually favorable. + termDef: + term: >- + Intraductal Papillary Breast Carcinoma + source: NCIt + cde_id: 'C4190 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4190 " + term_id: 'C4190 ' + term_version: 20.05a + +"85033": + common: + description: >- + A breast adenocarcinoma characterized by the presence of an intraductal papillary + carcinomatous component and an invasive carcinomatous component. + termDef: + term: >- + Intraductal Papillary Adenocarcinoma with Invasion + source: NCIt + cde_id: 'C7439 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7439 " + term_id: 'C7439 ' + term_version: 20.05a + +"85040": + common: + description: >- + A papillary epithelial neoplasm arising in a cystically dilated breast duct. + termDef: + term: >- + Intracystic Papilloma + source: NCIt + cde_id: C4191 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4191" + term_id: C4191 + term_version: 20.05a + +"85042": + common: + description: >- + An intraductal breast carcinoma characterized by a papillary growth within a + large cystic duct. There is no evidence of invasion of the breast parenchyma. + termDef: + term: >- + Intracystic Papillary Breast Carcinoma + source: NCIt + cde_id: C7645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7645" + term_id: C7645 + term_version: 20.05a + +"85043": + common: + description: >- + An intraductal breast carcinoma characterized by a papillary growth within a + large cystic duct. There is no evidence of invasion of the breast parenchyma. + termDef: + term: >- + Intracystic Papillary Breast Carcinoma + source: NCIt + cde_id: C7645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7645" + term_id: C7645 + term_version: 20.05a + +"85050": + common: + description: >- + A neoplastic process characterized by the presence of multiple intraductal papillomas. + termDef: + term: >- + Intraductal Papillomatosis + source: NCIt + cde_id: C7363 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7363" + term_id: C7363 + term_version: 20.05a + +"85060": + common: + description: >- + A benign epithelial neoplasm arising from the nipple. Signs and symptoms include + serous or sanguineous nipple discharge and nipple erosion. It is characterized + by the presence of aggregates of small tubules replacing the nipple stroma. + The tubules are lined by epithelial and myoepithelial cells. + termDef: + term: >- + Nipple Adenoma + source: NCIt + cde_id: C4192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4192" + term_id: C4192 + term_version: 20.05a + +"85092": + common: + description: >- + A well circumscribed, low grade neoplasm that arises from the breast. It is + characterized by the presence of sheets of malignant epithelial cells that are + supported by fibrovascular structures. When there is an invasive component + present, it is usually a mucinous carcinoma. + termDef: + term: >- + Solid Papillary Breast Carcinoma + source: NCIt + cde_id: C6870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6870" + term_id: C6870 + term_version: 20.05a + +"85103": + common: + description: >- + A term referring to medullary carcinomas which can develop in various anatomic + sites such as the thyroid gland, breast, colon, rectum, and small intestine. + termDef: + term: >- + Medullary Carcinoma, Not Otherwise Specified + source: NCIt + cde_id: C66718 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66718" + term_id: C66718 + term_version: 20.05a + +"85192": + common: + description: >- + A recently described aggressive subtype of classic lobular breast carcinoma + in situ. It is characterized by the presence of neoplastic large cells with + irregular nuclei and prominent single or multiple nucleoli. + termDef: + term: >- + Pleomorphic Lobular Breast Carcinoma In Situ + source: NCIt + cde_id: C137839 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137839" + term_id: C137839 + term_version: 20.05a + +"85202": + common: + description: >- + A non-invasive adenocarcinoma of the breast characterized by a proliferation + of monomorphic cells completely filling the lumina. The overall lobular architecture + is preserved. It is frequently multifocal (90% in some series) and bilateral. It + seldom becomes invasive; however there is an increased risk of infiltrating + ductal adenocarcinoma. + termDef: + term: >- + Lobular Breast Carcinoma In Situ + source: NCIt + cde_id: C4018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4018" + term_id: C4018 + term_version: 20.05a + +"85203": + common: + description: >- + An adenocarcinoma of the breast arising from the lobules. This is a relatively + uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas + and is often bilateral or multifocal. + termDef: + term: >- + Lobular Breast Carcinoma + source: NCIt + cde_id: 'C3771 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3771 " + term_id: 'C3771 ' + term_version: 20.05a + +"85213": + common: + description: >- + The most common type of invasive breast carcinoma, accounting for approximately + 70% of breast carcinomas. The gross appearance is usually typical with an irregular + stellate outline. Microscopically, randomly arranged epithelial elements are + seen. When large sheets of malignant cells are present, necrosis may be seen. With + adequate tissue sampling, in situ carcinoma can be demonstrated in association + with the infiltrating carcinoma. The in situ component is nearly always ductal + but occasionally may be lobular or both. + termDef: + term: >- + Invasive Ductal Carcinoma, Not Otherwise Specified + source: NCIt + cde_id: C4194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4194" + term_id: C4194 + term_version: 20.05a + +"85222": + common: + description: >- + The co-existence of ductal and lobular carcinoma in situ in the breast, without + evidence of stromal invasion. + termDef: + term: >- + Ductal Breast Carcinoma In Situ and Lobular Carcinoma In Situ + source: NCIt + cde_id: C4195 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4195" + term_id: C4195 + term_version: 20.05a + +"85223": + common: + description: >- + An invasive ductal breast carcinoma associated with a lobular carcinomatous + component. The lobular carcinomatous component may be in situ or invasive. + termDef: + term: >- + Invasive Ductal and Lobular Carcinoma + source: NCIt + cde_id: 'C7688 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7688 " + term_id: 'C7688 ' + term_version: 20.05a + +"85403": + common: + description: >- + A malignant neoplasm in which there is infiltration of the skin overlying the + breast by neoplastic large cells with abundant pale cytoplasm and large nuclei + with prominent nucleoli (Paget cells). It is almost always associated with an + intraductal or invasive ductal carcinoma of the breast. The clinical features + include focal skin reddening, and eczema. Retraction of the nipple may sometimes + occur. + termDef: + term: >- + Paget Disease of the Breast + source: NCIt + cde_id: C47857 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47857" + term_id: C47857 + term_version: 20.05a + +"85423": + common: + description: >- + A malignant neoplasm in which there is infiltration of the skin by neoplastic + large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli + (Paget cells). It may affect the anus, penis, scrotum, and vulva. + termDef: + term: >- + Extramammary Paget Disease + source: NCIt + cde_id: C3302 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3302" + term_id: C3302 + term_version: 20.05a + +"85433": + common: + description: >- + Paget disease of the breast associated with the presence of a usually high grade + ductal carcinoma in situ in the lactiferous glands. + termDef: + term: >- + Paget Disease and Intraductal Carcinoma of the Breast + source: NCIt + cde_id: C4019 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4019" + term_id: C4019 + term_version: 20.05a + +"85500": + common: + description: >- + A benign glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. + termDef: + term: >- + Acinar Cell Adenoma + source: NCIt + cde_id: C4196 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4196" + term_id: C4196 + term_version: 20.05a + +"85501": + common: + description: >- + A benign or malignant glandular epithelial neoplasm consisting of secretory + cells forming acinar patterns. It includes the acinar cell adenoma and acinar + cell carcinoma. + termDef: + term: >- + Acinar Cell Neoplasm + source: NCIt + cde_id: 'C4197 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4197 " + term_id: 'C4197 ' + term_version: 20.05a + +"85503": + common: + description: >- + A malignant glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. Representative examples include the acinar cell carcinoma of + the pancreas and the acinar adenocarcinoma of the prostate gland. + termDef: + term: >- + Acinar Cell Carcinoma + source: NCIt + cde_id: C3768 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3768" + term_id: C3768 + term_version: 20.05a + +"85513": + common: + description: >- + A cystic adenocarcinoma characterized by the presence of relatively uniform + neoplastic cells which produce pancreatic enzymes and are arranged in acinar + patterns. Signs and symptoms include abdominal pain, weight loss, nausea, and + diarrhea. It usually has an aggressive clinical course. + termDef: + term: >- + Pancreatic Acinar Cell Cystadenocarcinoma + source: NCIt + cde_id: C5727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5727" + term_id: C5727 + term_version: 20.05a + +"85603": + common: + description: >- + An invasive carcinoma composed of malignant glandular cells and malignant squamous + cells. + termDef: + term: >- + Adenosquamous Carcinoma + source: NCIt + cde_id: C3727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3727" + term_id: C3727 + term_version: 20.05a + +"85610": + common: + description: >- + An adenoma characterized by an oncocytic, often papillary, epithelial component, + dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid + gland, and is the second most common benign parotid salivary gland tumor. A + strong association with smoking has been reported. It typically presents as + a painless swelling in the lower portion of the parotid gland. + termDef: + term: >- + Warthin Tumor + source: NCIt + cde_id: C2854 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2854" + term_id: C2854 + term_version: 20.05a + +"85623": + common: + description: >- + A malignant neoplasm which occurs mostly in the major salivary glands (most + frequently in the parotid gland), but also in the minor salivary glands of the + oral mucosa and the tracheobronchial tree. It is characterized by the presence + of ductal structures which are lined by an inner layer of cuboidal epithelial-type + cells and an outer layer of myoepithelial cells with clear or eosinophilic cytoplasm. + termDef: + term: >- + Epithelial-Myoepithelial Carcinoma + source: NCIt + cde_id: C4199 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4199" + term_id: C4199 + term_version: 20.05a + +"85703": + common: + description: >- + An invasive adenocarcinoma characterized by the presence of focal or extensive + transformation of malignant glandular cells to squamous epithelial cells. + termDef: + term: >- + Adenocarcinoma with Squamous Metaplasia + source: NCIt + cde_id: C4200 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4200" + term_id: C4200 + term_version: 20.05a + +"85713": + common: + description: >- + An invasive adenocarcinoma characterized by focal or extensive cartilage and/or + bone formation. + termDef: + term: >- + Adenocarcinoma with Cartilaginous and Osseous Metaplasia + source: NCIt + cde_id: 'C7683 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7683 " + term_id: 'C7683 ' + term_version: 20.05a + +"85723": + common: + description: >- + An invasive adenocarcinoma characterized by focal or extensive transformation + of the malignant glandular cells to spindle-shaped cells. + termDef: + term: >- + Adenocarcinoma with Spindle Cell Metaplasia + source: NCIt + cde_id: C4201 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4201" + term_id: C4201 + term_version: 20.05a + +"85733": + common: + description: >- + An invasive adenocarcinoma characterized by focal or extensive transformation + of the malignant glandular cells to cells with abundant, usually granular eosinophilic + cytoplasm. + termDef: + term: >- + Adenocarcinoma with Apocrine Metaplasia + source: NCIt + cde_id: C4202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4202" + term_id: C4202 + term_version: 20.05a + +"85743": + common: + description: >- + An invasive adenocarcinoma characterized by the presence of focal or extensive + neurosecretory cell differentiation with the formation of organoid patterns. + termDef: + term: >- + Adenocarcinoma with Neuroendocrine Differentiation + source: NCIt + cde_id: C66745 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66745" + term_id: C66745 + term_version: 20.05a + +"85753": + common: + description: >- + A general term used to describe carcinomas arising from epithelial cells that + have been transformed into another cells type (metaplastic epithelial cells). + A representative example is the adenocarcinoma arising in Barrett esophagus. + This term is also used to describe carcinomas in which the malignant epithelial + cells show differentiation towards another cell type. A representative example + of the latter is the metaplastic breast carcinoma in which the malignant glandular + cells show squamous, spindle cell, or chondroid/osseous differentiation. + termDef: + term: >- + Metaplastic Carcinoma + source: NCIt + cde_id: C27949 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27949" + term_id: C27949 + term_version: 20.05a + +"85763": + common: + description: >- + An adenocarcinoma with morphologic characteristics similar to hepatocellular + carcinoma, arising from an anatomic site other than the liver. + termDef: + term: >- + Hepatoid Adenocarcinoma + source: NCIt + cde_id: C66950 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66950" + term_id: C66950 + term_version: 20.05a + +"85800": + common: + description: >- + A thymoma that is completely surrounded by a capsule, without evidence of capsular + invasion, infiltration of the surrounding tissues, and metastases. + termDef: + term: >- + Benign Thymoma + source: NCIt + cde_id: C66746 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66746" + term_id: C66746 + term_version: 20.05a + +"85801": + common: + description: >- + A neoplasm arising from the epithelial cells of the thymus. Although thymomas + are usually encapsulated tumors, they may invade the capsule and infiltrate + the surrounding tissues or even metastasize to distant anatomic sites. The + following morphologic subtypes are currently recognized: type A, type B, type + AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas + type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually + has the most aggressive clinical course. + termDef: + term: >- + Thymoma + source: NCIt + cde_id: C3411 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3411" + term_id: C3411 + term_version: 20.05a + +"85803": + common: + description: >- + A thymoma that has an aggressive clinical course (capsular invasion, infiltration + of the surrounding tissues) and can metastasize. Although any morphologic subtype + of thymoma may eventually have a malignant clinical course, this term is most + often associated with thymoma types B3 and C. + termDef: + term: >- + Malignant Thymoma + source: NCIt + cde_id: C7612 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7612" + term_id: C7612 + term_version: 20.05a + +"85811": + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of spindle and/or + oval neoplastic epithelial cells. Lymphocytic infiltration is minimal or absent. + It may be associated with myasthenia gravis or pure red cell aplasia. The majority + of cases occur in the anterior mediastinum as Masaoka stage I tumors. Approximately + 20% of the cases occur as stage II or stage III tumors. Type A thymoma generally + behaves as a benign tumor and the overall survival is reported to be 100% at + 5 and 10 years. + termDef: + term: >- + Thymoma Type A + source: NCIt + cde_id: C6454 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6454" + term_id: C6454 + term_version: 20.05a + +"85813": + common: + description: >- + A type A thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type A Thymoma + source: NCIt + cde_id: C7999 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7999" + term_id: C7999 + term_version: 20.05a + +"85821": + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of a lymphocyte-poor + component similar to that seen in type A thymoma and a lymphocyte-rich component + which contains neoplastic small polygonal epithelial cells. It may be associated + with myasthenia gravis and pure red cell aplasia. The majority of cases occur + in the anterior mediastinum as Masaoka stage I tumors. A minority of the cases + occur as stage II or stage III tumors. The overall survival is reported to be + 80-100% at 5 and 10 years. + termDef: + term: >- + Thymoma Type AB + source: NCIt + cde_id: C6885 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6885" + term_id: C6885 + term_version: 20.05a + +"85823": + common: + description: >- + A type AB thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type AB Thymoma + source: NCIt + cde_id: C6886 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6886" + term_id: C6886 + term_version: 20.05a + +"85831": + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of expanded areas + which resemble the normal thymic cortex. The neoplastic epithelial cells are + small and scant and there is a dense T-lymphocytic component present. Areas + of medullary differentiation with or without Hassall's corpuscles are also present. + It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. + It has a low grade malignant potential. The majority of cases occur in the anterior + mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage + II tumors. + termDef: + term: >- + Thymoma Type B1 + source: NCIt + cde_id: C6887 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6887" + term_id: C6887 + term_version: 20.05a + +"85833": + common: + description: >- + A type B1 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B1 Thymoma + source: NCIt + cde_id: C7996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7996" + term_id: C7996 + term_version: 20.05a + +"85841": + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of neoplastic large, + polygonal epithelial cells with large vesicular nuclei and prominent nucleoli. + The neoplastic cells are arranged around perivascular spaces and along septa. + Immature T-lymphocytes are also present. It may be associated with myasthenia + gravis, pure red cell aplasia, and hypogammaglobulinemia. It is a tumor of moderate + malignancy. The majority of cases occur in the anterior mediastinum as Masaoka + stage I, stage II, or stage III tumors. Metastatic, stage IV tumors occur less + frequently. + termDef: + term: >- + Thymoma Type B2 + source: NCIt + cde_id: C6888 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6888" + term_id: C6888 + term_version: 20.05a + +"85843": + common: + description: >- + A type B2 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B2 Thymoma + source: NCIt + cde_id: C6889 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6889" + term_id: C6889 + term_version: 20.05a + +"85851": + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +"85853": + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +"85863": + common: + description: >- + A diverse group of carcinomas of the thymus gland, previously known as thymoma + type C. It includes morphologic variants derived from purely epithelial cells, + as well as from cells with neuroendocrine differentiation. + termDef: + term: >- + Thymic Carcinoma + source: NCIt + cde_id: C7569 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7569" + term_id: C7569 + term_version: 20.05a + +"85870": + common: + description: >- + A benign, well-circumscribed tumor of the neck occurring in adults. It is characterized + by the presence of spindle cells, epithelial islands, and adipose tissue. There + is no evidence of thymic origin or differentiation, despite the use of the term + thymoma in the literature. + termDef: + term: >- + Ectopic Hamartomatous Thymoma + source: NCIt + cde_id: C53595 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53595" + term_id: C53595 + term_version: 20.05a + +"85883": + common: + description: >- + A rare, slow growing, primary malignant tumor of the thyroid gland characterized + by a lobulated architectural pattern and the presence of a biphasic cellular + population composed of spindle epithelial cells and glandular cells. A small + number of cases are composed exclusively of spindle epithelial cells or glandular + cells. + termDef: + term: >- + Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation + source: NCIt + cde_id: C46105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46105" + term_id: C46105 + term_version: 20.05a + +"85893": + common: + description: >- + A rare primary carcinoma of the thyroid gland, composed of groups of carcinoma + cells with thymic epithelial differentiation. + termDef: + term: >- + Intrathyroid Thymic Carcinoma + source: NCIt + cde_id: C46106 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46106" + term_id: C46106 + term_version: 20.05a + +"85901": + common: + description: >- + A benign or malignant neoplasm that arises from the ovary and is composed of + granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative + examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor. + termDef: + term: >- + Ovarian Sex Cord-Stromal Tumor + source: NCIt + cde_id: 'C4862 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4862 " + term_id: 'C4862 ' + term_version: 20.05a + +"85911": + common: + description: >- + A sex cord-stromal tumor of the testis in which the neoplastic cells do not + show specific differentiation. + termDef: + term: >- + Unclassified Testicular Sex Cord-Stromal Tumor + source: NCIt + cde_id: C66748 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66748" + term_id: C66748 + term_version: 20.05a + +"85921": + common: + description: >- + A sex cord-stromal tumor of the testis which may contain any combination of + cell types, for example Sertoli cells, Leydig cells, and granulosa cells. Symptoms + include testicular swelling and gynecomastia. + termDef: + term: >- + Mixed Testicular Sex Cord-Stromal Tumor + source: NCIt + cde_id: C66991 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66991" + term_id: C66991 + term_version: 20.05a + +"85931": + common: + description: >- + A rare, benign sex cord-stromal tumor of the ovary characterized by the presence + of a fibrothecomatous stroma and scattered sex cord elements. Although it is + usually hormonally inactive, cases associated with endometrial hyperplasia or + adenocarcinoma have been reported. + termDef: + term: >- + Ovarian Stromal Tumor with Minor Sex Cord Elements + source: NCIt + cde_id: C66749 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66749" + term_id: C66749 + term_version: 20.05a + +"86000": + common: + description: >- + An ovarian or testicular stromal tumor characterized by the presence of lipid-rich + neoplastic spindle cells. In females, uterine bleeding is the most common symptom. + A minority of post-menopausal women with thecoma have an associated endometrial + adenocarcinoma or rarely a malignant mixed mullerian tumor or endometrial stromal + sarcoma. Rare cases with nuclear atypia and mitotic activity may metastasize. + In males, thecomas are rare and they usually present as slow growing, sometimes + painful masses. Metastases have not been reported. + termDef: + term: >- + Thecoma + source: NCIt + cde_id: C3405 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3405" + term_id: C3405 + term_version: 20.05a + +"86003": + common: + description: >- + A thecoma of the ovary which may metastasize to another anatomic site. It is + usually characterized by nuclear atypia and mitotic activity. Malignant thecomas + are rare. + termDef: + term: >- + Malignant Ovarian Thecoma + source: NCIt + cde_id: C6929 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6929" + term_id: C6929 + term_version: 20.05a + +"86010": + common: + description: >- + A variant of ovarian thecoma characterized by the presence of lutein cells. + It is associated with a lower frequency of estrogenic manifestations compared + to typical thecomas. In a minority of cases androgenic manifestations are present. + termDef: + term: >- + Ovarian Luteinized Thecoma + source: NCIt + cde_id: C4203 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4203" + term_id: C4203 + term_version: 20.05a + +"86020": + common: + description: >- + A benign ovarian stromal tumor characterized by the presence of cellular areas + which contain fibroblasts and round cells. The cellular areas are separated + by sclerotic or edematous hypocellular tissue. Symptoms include abdominal discomfort + and menstrual abnormalities. + termDef: + term: >- + Ovarian Sclerosing Stromal Tumor + source: NCIt + cde_id: C4204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4204" + term_id: C4204 + term_version: 20.05a + +"86100": + common: + description: >- + A benign ovarian stromal tumor in which more than 90% of the tumor cells resemble + steroid hormone-secreting cells. Crystals of Reinke are not present. It occurs + in post-menopausal women and it is usually associated with estrogenic effects. + termDef: + term: >- + Ovarian Stromal Luteoma + source: NCIt + cde_id: C3202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3202" + term_id: C3202 + term_version: 20.05a + +"86201": + common: + description: >- + A granulosa cell tumor occurring in the ovary and rarely in the testis. It is + composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic + cells may form various patterns including the microfollicular, which is characterized + by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, + and diffuse pattern. In females, it affects middle aged to post-menopausal women. + Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic + and rarely androgenic manifestations may be present. The vast majority of cases + present as stage I tumors; however, all tumors have a potential for aggressive + clinical course. In males, it is reported in the age range of 16-76 years and + the average age at presentation is 44 years. A minority of patients have gynecomastia. + Metastases have been reported in a minority of patients. + termDef: + term: >- + Adult Type Granulosa Cell Tumor + source: NCIt + cde_id: 'C66750 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66750 " + term_id: 'C66750 ' + term_version: 20.05a + +"86203": + common: + description: >- + A granulosa cell tumor which has an aggressive clinical course and metastasizes + to other anatomic sites. + termDef: + term: >- + Malignant Granulosa Cell Tumor + source: NCIt + cde_id: C4205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4205" + term_id: C4205 + term_version: 20.05a + +"86211": + common: + description: >- + A general term used to describe sex cord-stromal tumors characterized by the + presence of granulosa cells in a thecomatous/fibrothecomatous background. + termDef: + term: >- + Granulosa Cell-Theca Cell Tumor + source: NCIt + cde_id: C66751 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66751" + term_id: C66751 + term_version: 20.05a + +"86221": + common: + description: >- + A granulosa cell tumor occurring in the ovary and testis. In females it occurs + predominantly in the first three decades of life and presents unilaterally as + stage I disease in the vast majority of cases. It is characterized by the presence + of granulosa cells forming macrofollicular structures. The majority of cases + have a good prognosis. In males it represents the most frequent congenital testicular + neoplasm and the vast majority of cases occur in the perinatal period. It presents + as a scrotal or abdominal mass and it more often affects the left testis. Approximately + 20% of the patients have ambiguous external genitalia. It is characterized by + the presence of cystic spaces lined by granulosa cells and cells resembling + theca cells. Metastases have not been reported. + termDef: + term: >- + Juvenile Type Granulosa Cell Tumor + source: NCIt + cde_id: C4207 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4207" + term_id: C4207 + term_version: 20.05a + +"86300": + common: + description: >- + A Sertoli cell tumor of the testis or the ovary which remains localized and + does not metastasize to another anatomic site. + termDef: + term: >- + Benign Sertoli Cell Tumor + source: NCIt + cde_id: C67012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67012" + term_id: C67012 + term_version: 20.05a + +"86301": + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +"86303": + common: + description: >- + A Sertoli cell tumor that arises from the testis or the ovary. It is characterized + by nuclear pleomorphism, increased mitotic activity and necrotic changes. Metastases + may be present at diagnosis. + termDef: + term: >- + Malignant Sertoli Cell Tumor + source: NCIt + cde_id: C67006 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67006" + term_id: C67006 + term_version: 20.05a + +"86311": + common: + description: >- + A Sertoli-Leydig cell tumor of the ovary characterized by the presence of spindle-shaped + gonadal stromal cells and Sertoli cells, some of which are atypical. Leydig + cells are also present forming clusters at the periphery of the cellular aggregates. + Metastases have been reported in a minority of patients. + termDef: + term: >- + Moderately Differentiated Ovarian Sertoli-Leydig Cell Tumor + source: NCIt + cde_id: 'C39968 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39968 " + term_id: 'C39968 ' + term_version: 20.05a + +"86321": + common: + description: >- + A rare neoplasm arising from the ovary. Although it may occur at any age, it + is more often seen in young females. Morphologically, it is characterized by + a mixture of two cellular populations: well differentiated Sertoli cells and + granulosa cells, with the latter constituting at least ten percent of the neoplasm. + The vast majority of cases are stage I lesions at presentation and produce either + estrogenic or androgenic manifestations. Although it may present as a massive + ovarian tumor, it usually follows a benign clinical course. Very rare case reports + of testicular lesions morphologically resembling gynandroblastomas are in fact + variants of juvenile granulose cell tumor, or Sertoli cell tumor, or a combination + of both. + termDef: + term: >- + Ovarian Gynandroblastoma + source: NCIt + cde_id: C3072 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3072" + term_id: C3072 + term_version: 20.05a + +"86401": + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +"86500": + common: + description: >- + A Leydig cell tumor which does not recur or metastasize. Morphologically, there + is no evidence of cellular atypia, increased mitotic activity, necrosis, or + vascular invasion. + termDef: + term: >- + Benign Leydig Cell Tumor + source: NCIt + cde_id: C4212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4212" + term_id: C4212 + term_version: 20.05a + +"86501": + common: + description: >- + A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It + is predominantly or completely composed of Leydig cells which may contain crystals + of Reinke. In males it usually presents as a painless testicular enlargement + and it may be associated with gynecomastia and decreased libido. The majority + of the cases have a benign clinical course. Approximately 10% of the cases have + a malignant clinical course and metastasize. In females it may be associated + with androgenic manifestations and it follows a benign clinical course. + termDef: + term: >- + Leydig Cell Tumor + source: NCIt + cde_id: C3188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3188" + term_id: C3188 + term_version: 20.05a + +"86503": + common: + description: >- + A Leydig cell tumor characterized by large tumor size, the presence of cytologic + atypia, increased mitotic activity, necrosis, and vascular invasion. Approximately + 10% of the testicular Leydig cell tumors show malignant characteristics and + metastasize. Leydig cell tumors of the ovary follow a benign clinical course. + termDef: + term: >- + Malignant Leydig Cell Tumor + source: NCIt + cde_id: C4213 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4213" + term_id: C4213 + term_version: 20.05a + +"86600": + common: + description: >- + A benign Leydig cell tumor which arises in the hilar area of the ovary. + termDef: + term: >- + Ovarian Hilus Cell Tumor + source: NCIt + cde_id: C4214 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4214" + term_id: C4214 + term_version: 20.05a + +"86700": + common: + description: >- + An ovarian tumor in which the vast majority of the cells (more than 90% of the + tumor cells) resemble steroid hormone-secreting cells. It usually presents with + androgenic manifestations. Approximately one-third of the cases follow a malignant + clinical course. + termDef: + term: >- + Ovarian Steroid Cell Tumor + source: NCIt + cde_id: C4215 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4215" + term_id: C4215 + term_version: 20.05a + +"86710": + common: + description: >- + A benign, testicular or ovarian tumor, derived from adrenal embryonic rest cells. + It is composed of hyperplastic adrenal cortical tissue, and it is associated + with congenital adrenal hyperplasia. + termDef: + term: >- + Adrenal Rest Tumor + source: NCIt + cde_id: C2860 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2860" + term_id: C2860 + term_version: 20.05a + +"86800": + common: + description: >- + A paraganglioma that is confined to the site of origin, without metastatic potential. + termDef: + term: >- + Benign Paraganglioma + source: NCIt + cde_id: C48314 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48314" + term_id: C48314 + term_version: 20.05a + +"86801": + common: + description: >- + A benign or malignant neoplasm arising from paraganglia located along the sympathetic + or parasympathetic nerves. Infrequently, it may arise outside the usual distribution + of the sympathetic and parasympathetic paraganglia. Tumors arising from the + adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas + usually display a nesting (Zellballen) growth pattern. There are no reliable + morphologic criteria to distinguish between benign and malignant paragangliomas. The + only definitive indicator of malignancy is the presence of regional or distant + metastases. + termDef: + term: >- + Paraganglioma + source: NCIt + cde_id: C3308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3308" + term_id: C3308 + term_version: 20.05a + +"86803": + common: + description: >- + A paraganglioma that metastasizes to regional or distant anatomic sites. Extraadrenal + paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas. Common + sites of metastasis include the lymph nodes, lungs, bones, and liver. + termDef: + term: >- + Malignant Paraganglioma + source: NCIt + cde_id: C8559 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8559" + term_id: C8559 + term_version: 20.05a + +"86811": + common: + description: >- + A benign or malignant paraganglioma arising from the chromaffin cells of the + paraganglia that are located along the sympathetic nerves. It includes extra-adrenal + paragangliomas and paragangliomas that arise from the adrenal medulla. The + latter are commonly referred to as pheochromocytomas. Representative examples + of extra-adrenal sympathetic paragangliomas include the bladder, and superior + and inferior paraaortic paragangliomas. Clinical signs are related to the secretion + of catecholamines resulting in hypertension. + termDef: + term: >- + Sympathetic Paraganglioma + source: NCIt + cde_id: C4216 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4216" + term_id: C4216 + term_version: 20.05a + +"86821": + common: + description: >- + A benign or malignant, usually non-functioning, extra-adrenal paraganglioma + that arises from paraganglia located along the parasympathetic nerves. Representative + examples include aorticopulmonary, carotid body, jugulotympanic, and mediastinal + paragangliomas. + termDef: + term: >- + Parasympathetic Paraganglioma + source: NCIt + cde_id: C4217 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4217" + term_id: C4217 + term_version: 20.05a + +"86830": + common: + description: >- + A benign or malignant neoplasm arising from paraganglia located along the sympathetic + or parasympathetic nerves. Infrequently, it may arise outside the usual distribution + of the sympathetic and parasympathetic paraganglia. Tumors arising from the + adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas + usually display a nesting (Zellballen) growth pattern. There are no reliable + morphologic criteria to distinguish between benign and malignant paragangliomas. The + only definitive indicator of malignancy is the presence of regional or distant + metastases. + termDef: + term: >- + Paraganglioma + source: NCIt + cde_id: C3308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3308" + term_id: C3308 + term_version: 20.05a + +"86901": + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma arising from + paraganglia in the base of the skull and middle ear. + termDef: + term: >- + Jugulotympanic Paraganglioma + source: NCIt + cde_id: C3061 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3061" + term_id: C3061 + term_version: 20.05a + +"86911": + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma that arises + from paraganglia adjacent to the base of the heart and great vessels. + termDef: + term: >- + Aorticopulmonary Paraganglioma + source: NCIt + cde_id: C4218 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4218" + term_id: C4218 + term_version: 20.05a + +"86921": + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma arising from + paraganglia adjacent to or in the bifurcation of the common carotid artery. Most + patients present with a slow growing, painless mass in the neck. + termDef: + term: >- + Carotid Body Paraganglioma + source: NCIt + cde_id: C2932 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2932" + term_id: C2932 + term_version: 20.05a + +"86931": + common: + description: >- + A benign or malignant paraganglioma arising from sympathetic or parasympathetic + paraganglia outside the adrenal gland. + termDef: + term: >- + Extra-Adrenal Paraganglioma + source: NCIt + cde_id: 'C3309 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3309 " + term_id: 'C3309 ' + term_version: 20.05a + +"86933": + common: + description: >- + An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic + sites. Common sites of metastasis include the lymph nodes, lungs, bones, and + liver. + termDef: + term: >- + Malignant Extra-Adrenal Paraganglioma + source: NCIt + cde_id: C4219 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4219" + term_id: C4219 + term_version: 20.05a + +"87000": + common: + description: >- + A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system + that secretes catecholamines. It arises from the chromaffin cells of the adrenal + medulla. Clinical presentation includes headaches, palpitations, chest and + abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic + nesting (zellballen) growth pattern is usually seen. Other growth patterns + including trabecular pattern may also be present. + termDef: + term: >- + Adrenal Gland Pheochromocytoma + source: NCIt + cde_id: 'C3326 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3326 " + term_id: 'C3326 ' + term_version: 20.05a + +"87003": + common: + description: >- + A pheochromocytoma that metastasizes to other anatomic sites. Common sites + of metastasis include lymph nodes, bones, liver, and lung. Morphologic features + associated with malignant pheochromocytomas include: atypical mitotic figures, + capsular and vascular invasion, tumor cell necrosis, and high mitotic activity. + termDef: + term: >- + Malignant Adrenal Gland Pheochromocytoma + source: NCIt + cde_id: C4220 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4220" + term_id: C4220 + term_version: 20.05a + +"87103": + common: + description: >- + A very rare morphologic variant of glomus tumor with a size greater than 2 cm. The + tumor arises in subfascial or visceral tissues. It is characterized by the presence + of atypical mitotic figures, or marked nuclear atypia, or the combination of + both. It has an aggressive clinical course. + termDef: + term: >- + Malignant Glomus Tumor + source: NCIt + cde_id: C4221 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4221" + term_id: C4221 + term_version: 20.05a + +"87110": + common: + description: >- + A rare benign or malignant mesenchymal neoplasm arising from cells that resemble + the modified smooth muscle cells of the glomus body. The majority of glomus + tumors occur in the distal extremities. + termDef: + term: >- + Glomus Tumor + source: NCIt + cde_id: C3060 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3060" + term_id: C3060 + term_version: 20.05a + +"87113": + common: + description: >- + A very rare morphologic variant of glomus tumor with a size greater than 2 cm. The + tumor arises in subfascial or visceral tissues. It is characterized by the presence + of atypical mitotic figures, or marked nuclear atypia, or the combination of + both. It has an aggressive clinical course. + termDef: + term: >- + Malignant Glomus Tumor + source: NCIt + cde_id: C4221 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4221" + term_id: C4221 + term_version: 20.05a + +"87120": + common: + description: >- + A morphologic variant of the glomus tumor characterized by the presence of dilated + veins, surrounded by small clusters of glomus cells. Glomangiomas are most often + present in patients with multiple lesions. + termDef: + term: >- + Glomangioma + source: NCIt + cde_id: C4222 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4222" + term_id: C4222 + term_version: 20.05a + +"87130": + common: + description: >- + A morphologic variant of the glomus tumor with architectural features similar + to solid glomus tumor. It is characterized by the presence of elongated glomus + cells which resemble mature smooth muscle. + termDef: + term: >- + Glomangiomyoma + source: NCIt + cde_id: C4223 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4223" + term_id: C4223 + term_version: 20.05a + +"87143": + common: + description: >- + A usually large and aggressive tumor with perivascular epithelioid cell differentiation + characterized by the presence of marked nuclear atypia, pleomorphism, increased + mitotic activity, necrosis, and infiltrative margins. The most common metastatic + sites are liver, lungs, lymph nodes, and bone. + termDef: + term: >- + Malignant PEComa + source: NCIt + cde_id: C121792 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121792" + term_id: C121792 + term_version: 20.05a + +"87200": + common: + description: >- + A nevus characterised by the presence of excessive pigment. + termDef: + term: >- + Pigmented Nevus + source: NCIt + cde_id: 'C27816 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27816 " + term_id: 'C27816 ' + term_version: 20.05a + +"87202": + common: + description: >- + Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. N0: No regional lymph + node metastases. M0: No detectable evidence of distant metastases. (from AJCC + 6th and 7th Eds.) + termDef: + term: >- + Stage 0 Cutaneous Melanoma AJCC v6 and v7 + source: NCIt + cde_id: C8423 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8423" + term_id: C8423 + term_version: 20.05a + +"87203": + common: + description: >- + A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. + Most often, melanomas arise in the skin (cutaneous melanomas) and include the + following histologic subtypes: superficial spreading melanoma, nodular melanoma, + acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas + may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas + may also arise in other anatomic sites including the gastrointestinal system, + eye, urinary tract, and reproductive system. Melanomas frequently metastasize + to lymph nodes, liver, lungs, and brain. + termDef: + term: >- + Melanoma + source: NCIt + cde_id: C3224 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3224" + term_id: C3224 + term_version: 20.05a + +"87213": + common: + description: >- + An aggressive form of melanoma, frequently metastasizing to the lymph nodes. It + presents as a papular or nodular raised skin lesion. It comprises approximately + 10-15% of melanomas. Morphologically, it often displays an epithelioid appearance. + termDef: + term: >- + Cutaneous Nodular Melanoma + source: NCIt + cde_id: C4225 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4225" + term_id: C4225 + term_version: 20.05a + +"87220": + common: + description: >- + An uncommon variant of melanocytic nevus. It presents as a small pigmented skin + lesion. It is characterized by the presence of large melanocytes with clear, + foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised. + termDef: + term: >- + Balloon Cell Nevus + source: NCIt + cde_id: C4226 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4226" + term_id: C4226 + term_version: 20.05a + +"87223": + common: + description: >- + A rare variant of melanoma with a vertical growth phase. It presents as a nodular + or polypoid skin lesion. It is characterized by the presence of nodules which + contain large melanoma cells with clear, foamy or finely vacuolated cytoplasm. + The prognosis is similar to that of other melanomas matched for depth of invasion. + termDef: + term: >- + Balloon Cell Melanoma + source: NCIt + cde_id: C4227 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4227" + term_id: C4227 + term_version: 20.05a + +"87230": + common: + description: >- + A melanocytic nevus characterized by circumferential depigmentation. It is usually + associated with a brisk lymphocytic infiltrate. + termDef: + term: >- + Halo Nevus + source: NCIt + cde_id: 'C7602 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7602 " + term_id: 'C7602 ' + term_version: 20.05a + +"87233": + common: + description: >- + A skin lesion characterized by the disappearance of the melanoma cells from + the primary melanoma site. The disappearance of the malignant cells is associated + with fibroplasia of the papillary dermis. According to some authors, complete + regression of the primary melanoma may occur in 4-8% of patients. + termDef: + term: >- + Regressing Melanoma + source: NCIt + cde_id: C4228 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4228" + term_id: C4228 + term_version: 20.05a + +"87250": + common: + description: >- + An intradermal nevus characterized by the presence of nests of atrophic nevus + cells which are hyalinized and resemble nerve bundles. + termDef: + term: >- + Neuronevus + source: NCIt + cde_id: C4229 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4229" + term_id: C4229 + term_version: 20.05a + +"87260": + common: + description: >- + A benign melanocytic proliferation within or adjacent to the optic disk. It + presents as a pigmented, intraocular tumor. + termDef: + term: >- + Melanocytoma of the Eyeball + source: NCIt + cde_id: 'C4230 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4230 " + term_id: 'C4230 ' + term_version: 20.05a + +"87270": + common: + description: >- + Solitary or multiple, slightly raised pigmented melanocytic lesions with irregular + borders, usually measuring more than 0.6cm in greatest dimension. Morphologically, + there is melanocytic atypia and the differential diagnosis from melanoma may + be difficult. Patients are at an increased risk for the development of melanoma. + termDef: + term: >- + Dysplastic Nevus + source: NCIt + cde_id: C3694 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3694" + term_id: C3694 + term_version: 20.05a + +"87280": + common: + description: >- + A diffuse or multifocal proliferation of uniform nevoid polygonal cells in the + leptomeninges. Cells may spread into the Virchow-Robin spaces without frank + invasion of the brain. Diffuse melanocytosis carries a poor prognosis even in + the absence of histologic malignancy. (WHO) + termDef: + term: >- + Meningeal Melanocytosis + source: NCIt + cde_id: C6890 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6890" + term_id: C6890 + term_version: 20.05a + +"87281": + common: + description: >- + A usually well differentiated melanocytic neoplasm arising from the meninges. + It is characterized by the presence of epithelioid, fusiform, polyhedral, and + spindle melanocytes without evidence of hemorrhage, necrosis, or high mitotic + activity. Presenting symptoms include headache, vomiting, and neurological manifestations. + Complete excision is usually curative. + termDef: + term: >- + Meningeal Melanocytoma + source: NCIt + cde_id: C4662 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4662" + term_id: C4662 + term_version: 20.05a + +"87283": + common: + description: >- + A meningeal melanoma with secondary diffuse meningeal spread. (WHO) + termDef: + term: >- + Meningeal Melanomatosis + source: NCIt + cde_id: C6891 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6891" + term_id: C6891 + term_version: 20.05a + +"87300": + common: + description: >- + A benign nevus characterized by the absence of melanin pigment in the melanocytes. + termDef: + term: >- + Nonpigmented Nevus + source: NCIt + cde_id: C27095 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27095" + term_id: C27095 + term_version: 20.05a + +"87303": + common: + description: >- + A melanoma characterized by the complete absence of melanin pigment in the melanoma + cells. It occurs more frequently on the face and it is often associated with + desmoplastic reaction. + termDef: + term: >- + Amelanotic Melanoma + source: NCIt + cde_id: C3802 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3802" + term_id: C3802 + term_version: 20.05a + +"87400": + common: + description: >- + A nevus characterized by the presence of an intraepidermal proliferation of + nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. + It presents as a small, slightly raised, pigmented skin lesion. + termDef: + term: >- + Junctional Nevus + source: NCIt + cde_id: C4231 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4231" + term_id: C4231 + term_version: 20.05a + +"87403": + common: + description: >- + A melanoma arising from a melanocytic nevus which involves the dermal-epidermal + junction of the skin. + termDef: + term: >- + Melanoma in Junctional Nevus + source: NCIt + cde_id: C4232 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4232" + term_id: C4232 + term_version: 20.05a + +"87412": + common: + description: >- + Precancerous Melanosis + termDef: + term: >- + Precancerous Melanosis + source: NCIt + cde_id: C4233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4233" + term_id: C4233 + term_version: 20.05a + +"87413": + common: + description: >- + A melanoma arising from an atypical intraepithelial melanocytic hyperplasia. + termDef: + term: >- + Malignant Melanoma in Precancerous Melanosis + source: NCIt + cde_id: C66753 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66753" + term_id: C66753 + term_version: 20.05a + +"87422": + common: + description: >- + An atypical proliferation of atypical melanocytes in the dermal-epidermal junction, + without infiltration of the papillary or reticular dermis. The melanocytic proliferation + is associated with actinic damage and epidermal atrophy. It usually occurs + in the sun-exposed skin of elderly people. It is a form of melanoma in situ. + termDef: + term: >- + Lentigo Maligna + source: NCIt + cde_id: C43372 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43372" + term_id: C43372 + term_version: 20.05a + +"87423": + common: + description: >- + A melanoma of the skin characterized by single cell infiltration of the papillary + dermis by atypical melanocytes, in a background of lentigo maligna changes. + termDef: + term: >- + Lentigo Maligna Melanoma + source: NCIt + cde_id: C9151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9151" + term_id: C9151 + term_version: 20.05a + +"87433": + common: + description: >- + A type of melanoma that typically occurs in light-skinned individuals ranging + in age from young adults to the elderly. Risk factors include extensive sun + exposure during childhood, a family history of melanoma, and the presence of + dysplastic nevi. + termDef: + term: >- + Low-CSD Melanoma + source: NCIt + cde_id: C9152 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9152" + term_id: C9152 + term_version: 20.05a + +"87443": + common: + description: >- + A form of melanoma occurring most often on the plantar, palmar, subungual, and + periungual skin. It presents as a pigmented macular lesion with irregular borders. Morphologically, + it consists of atypical spindled and dendritic melanocytes. The epidermis is + often hyperplastic and there is pagetoid infiltration of the epidermis by anaplastic + cells. + termDef: + term: >- + Acral Lentiginous Melanoma + source: NCIt + cde_id: C4022 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4022" + term_id: C4022 + term_version: 20.05a + +"87453": + common: + description: >- + A melanoma of the skin characterized by a proliferation of atypical spindled + melanocytes in the dermis, in a background of abundant collagen. It usually + presents as an amelanotic raised nodular lesion. + termDef: + term: >- + Desmoplastic Melanoma + source: NCIt + cde_id: C37257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37257" + term_id: C37257 + term_version: 20.05a + +"87463": + common: + description: >- + An acral lentiginous melanoma affecting mucosal surfaces. + termDef: + term: >- + Mucosal Lentiginous Melanoma + source: NCIt + cde_id: C48622 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48622" + term_id: C48622 + term_version: 20.05a + +"87500": + common: + description: >- + A nevus characterized by the proliferation of nevus cells in the dermis without + involvement of the dermal-epidermal junction. + termDef: + term: >- + Dermal Nevus + source: NCIt + cde_id: C3804 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3804" + term_id: C3804 + term_version: 20.05a + +"87600": + common: + description: >- + A nevus composed of neoplastic melanocytes that infiltrate both the epidermis + and the dermis. + termDef: + term: >- + Compound Nevus + source: NCIt + cde_id: C3901 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3901" + term_id: C3901 + term_version: 20.05a + +"87611": + common: + description: >- + A rare melanocytic lesion occurring at birth, comprising at least 5% of the + body surface area. It usually presents as a dark brown to black hairy lesion. + Morphologically, it is characterized by the presence of a compound or intradermal + nevus. There is an increased risk of malignant transformation to melanoma, rhabdomyosarcoma, + and poorly differentiated malignant tumors. + termDef: + term: >- + Giant Congenital Nevus + source: NCIt + cde_id: C4234 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4234" + term_id: C4234 + term_version: 20.05a + +"87621": + common: + description: >- + A benign proliferation of epithelioid or spindled melanocytes usually in the + upper or mid dermis in a background of congenital melanocytic nevus. The congenital + melanocytic nevus is usually of the deep type, involving the dermis and extending + into the subcutaneous tissue. It presents as a dark plaque or nodule above a + giant congenital melanocytic nevus. + termDef: + term: >- + Proliferative Nodules in Congenital Melanocytic Nevus + source: NCIt + cde_id: C66755 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66755" + term_id: C66755 + term_version: 20.05a + +"87700": + common: + description: >- + A benign, acquired or congenital, usually single skin lesion. It can occur on + any area of the body, but most commonly occurs on the face of children and the + thighs of young females. It is characterized by a proliferation of large spindle, + oval, or large epithelioid melanocytes in the dermal-epidermal junction. The + melanocytic proliferation subsequently extends into the dermis. + termDef: + term: >- + Spitz Nevus + source: NCIt + cde_id: 'C27007 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27007 " + term_id: 'C27007 ' + term_version: 20.05a + +"87703": + common: + description: >- + A melanoma characterized by the presence of malignant large epithelioid melanocytes + and malignant spindle-shaped melanocytes. + termDef: + term: >- + Mixed Epithelioid and Spindle Cell Melanoma + source: NCIt + cde_id: C66756 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66756" + term_id: C66756 + term_version: 20.05a + +"87710": + common: + description: >- + A nevus characterized by the presence of large epithelioid melanocytes. + termDef: + term: >- + Epithelioid Cell Nevus + source: NCIt + cde_id: C66757 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66757" + term_id: C66757 + term_version: 20.05a + +"87713": + common: + description: >- + A melanoma characterized by the presence of malignant large epithelioid melanocytes. + termDef: + term: >- + Epithelioid Cell Melanoma + source: NCIt + cde_id: C4236 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4236" + term_id: C4236 + term_version: 20.05a + +"87720": + common: + description: >- + A benign, acquired or congenital, usually single skin lesion. It can occur on + any area of the body, but most commonly occurs on the face of children and the + thighs of young females. It is characterized by a proliferation of large spindle, + oval, or large epithelioid melanocytes in the dermal-epidermal junction. The + melanocytic proliferation subsequently extends into the dermis. + termDef: + term: >- + Spitz Nevus + source: NCIt + cde_id: C27007 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27007" + term_id: C27007 + term_version: 20.05a + +"87723": + common: + description: >- + A melanoma characterized by the presence of malignant spindle-shaped melanocytes. + termDef: + term: >- + Spindle Cell Melanoma + source: NCIt + cde_id: C4237 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4237" + term_id: C4237 + term_version: 20.05a + +"87733": + common: + description: >- + A melanoma characterized by the presence of malignant spindle-shaped melanocytes + with slender nuclei and no visible nucleoli. Representative example is the type + A spindle cell uveal melanoma. + termDef: + term: >- + Type A Spindle Cell Melanoma + source: NCIt + cde_id: C4238 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4238" + term_id: C4238 + term_version: 20.05a + +"87743": + common: + description: >- + A melanoma characterized by the presence of malignant spindle-shaped melanocytes + with larger nuclei and distinct nucleoli. Representative example is the type + B spindle cell uveal melanoma. + termDef: + term: >- + Type B Spindle Cell Melanoma + source: NCIt + cde_id: C4239 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4239" + term_id: C4239 + term_version: 20.05a + +"87800": + common: + description: >- + An intradermal nevus characterized by the presence of benign pigmented dendritic + spindle-shaped melanocytes. It most frequently occurs in the skin of the distal + upper extremities, followed by the lower extremities, scalp, face, and buttocks. + It usually presents as a single blue or blue-black papular lesion less than + 1cm in diameter. Simple excision is usually curative. + termDef: + term: >- + Blue Nevus + source: NCIt + cde_id: C3803 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3803" + term_id: C3803 + term_version: 20.05a + +"87803": + common: + description: >- + A rare melanoma which develops in a pre-existing blue nevus. It occurs more + frequently on the scalp, face, orbit, back, buttocks, extremities, hands, and + feet. + termDef: + term: >- + Melanoma Arising from Blue Nevus + source: NCIt + cde_id: C4240 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4240" + term_id: C4240 + term_version: 20.05a + +"87900": + common: + description: >- + A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell + architecture occupying the reticular dermis. The cellular infiltrate often extends + into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped + melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped + melanocytes. In occasional cases an increased mitotic activity, focal necrosis, + and nuclear pleomorphism may be seen. Such cases with atypical features may + have an uncertain malignant potential. + termDef: + term: >- + Cellular Blue Nevus + source: NCIt + cde_id: C4241 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4241" + term_id: C4241 + term_version: 20.05a + +"88000": + common: + description: >- + A non-metastasizing neoplasm that arises from the soft tissue. + termDef: + term: >- + Benign Soft Tissue Neoplasm + source: NCIt + cde_id: C4242 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4242" + term_id: C4242 + term_version: 20.05a + +"88003": + common: + description: >- + A usually aggressive malignant neoplasm of the soft tissue or bone. It arises + from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas + occur in both children and adults. The prognosis depends largely on the degree + of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, + leiomyosarcoma, osteosarcoma, and chondrosarcoma. + termDef: + term: >- + Sarcoma + source: NCIt + cde_id: 'C9118 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9118 " + term_id: 'C9118 ' + term_version: 20.05a + +"88009": + common: + description: >- + The occurrence of several sarcomas in different anatomic locations. + termDef: + term: >- + Sarcomatosis + source: NCIt + cde_id: C4243 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4243" + term_id: C4243 + term_version: 20.05a + +"88013": + common: + description: >- + A malignant mesenchymal neoplasm composed of spindle-shaped cells. This is + a morphologic term which can be applied to a wide range of sarcomas. + termDef: + term: >- + Spindle Cell Sarcoma + source: NCIt + cde_id: C27005 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27005" + term_id: C27005 + term_version: 20.05a + +"88023": + common: + description: >- + A sarcoma characterized by the presence of large, anaplastic malignant cells. + termDef: + term: >- + Giant Cell Sarcoma + source: NCIt + cde_id: C66759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66759" + term_id: C66759 + term_version: 20.05a + +"88033": + common: + description: >- + A sarcoma characterized by the presence of small round or elongated malignant + cells with a small amount of cytoplasm. + termDef: + term: >- + Small Cell Sarcoma + source: NCIt + cde_id: C3746 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3746" + term_id: C3746 + term_version: 20.05a + +"88043": + common: + description: >- + An aggressive malignant neoplasm of uncertain differentiation, characterized + by the presence of epithelioid cells forming nodular patterns. The nodules + often undergo central necrosis, resulting in a pseudogranulomatous growth pattern. It + usually occurs in young adults. The most common sites of involvement are the + extremities (distal-type epithelioid sarcoma), and less frequently the pelvis, + perineum, and genital organs (proximal-type epithelioid sarcoma). + termDef: + term: >- + Epithelioid Sarcoma + source: NCIt + cde_id: C3714 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3714" + term_id: C3714 + term_version: 20.05a + +"88053": + common: + description: >- + An undifferentiated soft tissue sarcoma which cannot be further characterized. + termDef: + term: >- + Undifferentiated Sarcoma, Not Otherwise Specified + source: NCIt + cde_id: C121804 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121804" + term_id: C121804 + term_version: 20.05a + +"88063": + common: + description: >- + An aggressive malignant soft tissue neoplasm of uncertain differentiation. It + is characterized by a recurrent chromosomal translocation t(11;22)(p13;q12) + and the presence of small round cells in a desmoplastic stroma. It usually + affects children and young adults. The most common site of involvement is the + abdomen. Patients usually present with abdominal distention, pain, ascites, + and a palpable abdominal mass. The prognosis is usually poor. + termDef: + term: >- + Desmoplastic Small Round Cell Tumor + source: NCIt + cde_id: C8300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8300" + term_id: C8300 + term_version: 20.05a + +"88100": + common: + description: >- + A non-metastasizing neoplasm arising from the fibrous tissue. It is characterized + by the presence of spindle-shaped fibroblasts. + termDef: + term: >- + Fibroma + source: NCIt + cde_id: C3041 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3041" + term_id: C3041 + term_version: 20.05a + +"88101": + common: + description: >- + A morphologic variant of fibroma characterized by increased cellularity. + termDef: + term: >- + Cellular Fibroma + source: NCIt + cde_id: C6892 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6892" + term_id: C6892 + term_version: 20.05a + +"88103": + common: + description: >- + A malignant mesenchymal fibroblastic neoplasm affecting the soft tissue and + bone. + termDef: + term: >- + Fibrosarcoma + source: NCIt + cde_id: C3043 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3043" + term_id: C3043 + term_version: 20.05a + +"88110": + common: + description: >- + A soft tissue tumor of uncertain lineage characterized by the presence of neoplastic + spindle-shaped to round cells in a fibromyxoid stroma. Metaplastic bone formation + may or may not be present. + termDef: + term: >- + Fibromyxoid Tumor + source: NCIt + cde_id: C66760 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66760" + term_id: C66760 + term_version: 20.05a + +"88111": + common: + description: >- + A low grade, locally aggressive, fibroblastic neoplasm that occurs primarily + in the distal extremities. It is characterized by the presence of spindle-shaped + fibroblasts, multivacuolated lipoblast-like cells, bizarre ganglion-like cells + with inclusion-like nuclei, myxoid stroma formation, and a mixture of acute + and chronic inflammatory cells. Distant metastases are very rare. + termDef: + term: >- + Myxoinflammatory Fibroblastic Sarcoma + source: NCIt + cde_id: C49025 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49025" + term_id: C49025 + term_version: 20.05a + +"88113": + common: + description: >- + A malignant fibroblastic neoplasm arising from the soft tissue. It is characterized + by the presence of spindle-shaped cells, cellular pleomorphism, thin-walled + blood vessels, fibrous septa, and myxoid stroma. + termDef: + term: >- + Myxofibrosarcoma + source: NCIt + cde_id: C6496 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6496" + term_id: C6496 + term_version: 20.05a + +"88120": + common: + description: >- + A benign fibrous neoplasm arising from the periosteal connective tissue that + surrounds a bone. + termDef: + term: >- + Periosteal Fibroma + source: NCIt + cde_id: C66761 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66761" + term_id: C66761 + term_version: 20.05a + +"88123": + common: + description: >- + A malignant fibroblastic tumor arising from the periosteal connective tissue + that surrounds a bone. + termDef: + term: >- + Periosteal Fibrosarcoma + source: NCIt + cde_id: C66763 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66763" + term_id: C66763 + term_version: 20.05a + +"88130": + common: + description: >- + A benign fibrous tumor arising from the fascial connective tissue. + termDef: + term: >- + Fascial Fibroma + source: NCIt + cde_id: C66764 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66764" + term_id: C66764 + term_version: 20.05a + +"88133": + common: + description: >- + A malignant fibroblastic neoplasm arising from the fascial connective tissue. + termDef: + term: >- + Fascial Fibrosarcoma + source: NCIt + cde_id: C66765 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66765" + term_id: C66765 + term_version: 20.05a + +"88143": + common: + description: >- + A fibrosarcoma that occurs in infants. It shares identical morphologic features + with adult fibrosarcoma but carries the t(12;15)(p13;q25) translocation that + results in ETV6-NTRK3 gene fusion. It usually affects the superficial and deep + soft tissues of the extremities. The prognosis is generally much more favorable + than for adult fibrosarcoma, and it rarely metastasizes. + termDef: + term: >- + Infantile Fibrosarcoma + source: NCIt + cde_id: C4244 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4244" + term_id: C4244 + term_version: 20.05a + +"88150": + common: + description: >- + A localized neoplasm of probable fibroblastic derivation. It is characterized + by the presence of round to spindle-shaped cells, hylanized stroma formation, + thin-walled branching blood vessels, and thin bands of collagen. + termDef: + term: >- + Solitary Fibrous Tumor + source: NCIt + cde_id: C7634 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7634" + term_id: C7634 + term_version: 20.05a + +"88151": + common: + description: >- + A solitary fibrous tumor/hemangiopericytoma that arises from the central nervous + system. It corresponds to the more cellular, less collagenous tumor with plump + cells and staghorn vasculature which was diagnosed as central nervous system + hemangiopericytoma in the past. + termDef: + term: >- + Central Nervous System Solitary Fibrous Tumor/Hemangiopericytoma, Grade 2 + source: NCIt + cde_id: C129528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129528" + term_id: C129528 + term_version: 20.05a + +"88153": + common: + description: >- + A malignant neoplasm of probable fibroblastic derivation. It is characterized + by the presence of atypical round to spindle-shaped cells, increased cellularity, + necrotic change and high mitotic activity. + termDef: + term: >- + Malignant Solitary Fibrous Tumor + source: NCIt + cde_id: C6894 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6894" + term_id: C6894 + term_version: 20.05a + +"88200": + common: + description: >- + A benign, slow-growing tumor arising from the soft tissues usually in the mid-thoracic + region of the elderly. It is characterized by the presence of paucicellular + collagenous tissue, adipocytes and a predominance of large coarse elastic fibers + arranged in globules. + termDef: + term: >- + Elastofibroma + source: NCIt + cde_id: C4245 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4245" + term_id: C4245 + term_version: 20.05a + +"88211": + common: + description: >- + An insidious, locally aggressive, poorly circumscribed neoplasm arising from + the deep soft tissues. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + It lacks metastatic potential. + termDef: + term: >- + Desmoid-Type Fibromatosis + source: NCIt + cde_id: 'C9182 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9182 " + term_id: 'C9182 ' + term_version: 20.05a + +"88221": + common: + description: >- + An insidious poorly circumscribed neoplasm arising from the deep soft tissues + of the abdomen. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + termDef: + term: >- + Abdominal (Mesenteric) Fibromatosis + source: NCIt + cde_id: C3741 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3741" + term_id: C3741 + term_version: 20.05a + +"88230": + common: + description: >- + A rare, benign, locally aggressive, osteolytic neoplasm. It is characterized + by the presence of a rich collagenous stroma and spindle cells with minimal + cellular atypia. + termDef: + term: >- + Bone Desmoplastic Fibroma + source: NCIt + cde_id: C3740 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3740" + term_id: C3740 + term_version: 20.05a + +"88240": + common: + description: >- + A benign, localized, nodular and well-circumscribed neoplasm usually seen as + a congenital neoplasm or in the first year of life. It is characterized by a + biphasic growth pattern and is composed of small, undifferentiated mesenchymal + cells associated with branching thin-walled vessels and more mature neoplastic + spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma. + termDef: + term: >- + Myofibroma + source: NCIt + cde_id: C7052 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7052" + term_id: C7052 + term_version: 20.05a + +"88241": + common: + description: >- + A benign, multifocal, nodular and well-circumscribed neoplasm usually seen as + a congenital neoplasm or in the first year of life. It is characterized by a + biphasic growth pattern and is composed of small, undifferentiated mesenchymal + cells associated with branching thin-walled vessels and more mature neoplastic + spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma. + termDef: + term: >- + Myofibromatosis + source: NCIt + cde_id: C3742 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3742" + term_id: C3742 + term_version: 20.05a + +"88250": + common: + description: >- + A benign, well circumscribed soft tissue neoplasm characterized by the presence + of spindle shaped myofibroblasts and mast cells in a collagenous stroma. + termDef: + term: >- + Myofibroblastoma + source: NCIt + cde_id: C49012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49012" + term_id: C49012 + term_version: 20.05a + +"88251": + common: + description: >- + A multinodular intermediate fibroblastic neoplasm that arises from soft tissue + or viscera, in children and young adults. It is characterized by the presence + of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory + infiltrate composed of eosinophils, lymphocytes, and plasma cells. + termDef: + term: >- + Inflammatory Myofibroblastic Tumor + source: NCIt + cde_id: C6481 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6481" + term_id: C6481 + term_version: 20.05a + +"88260": + common: + description: >- + A benign myofibroblastic neoplasm, usually arising in the pelviperineal region. + It is characterized by the presence of neoplastic spindle to round cells, dilated + thin walled vessels, and stromal edema. Most patients present with painless + circumscribed masses. + termDef: + term: >- + Angiomyofibroblastoma + source: NCIt + cde_id: C49016 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49016" + term_id: C49016 + term_version: 20.05a + +"88300": + common: + description: >- + A benign neoplasm composed of fibroblastic spindle cells in a whorled storiform + pattern. It is characterized by the presence of foam cells, inflammatory cells, + hemosiderin deposition and stromal hemorrhage. + termDef: + term: >- + Benign Fibrous Histiocytoma + source: NCIt + cde_id: C3739 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3739" + term_id: C3739 + term_version: 20.05a + +"88301": + common: + description: >- + An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, + usually affecting the actinic-damaged skin of the elderly. The tumor presents + as a single cutaneous nodule which is often ulcerated. Microscopically, it + is characterized by the presence of highly atypical cytologic features, pleomorphism + and abundant mitotic figures. The vast majority of patients have an excellent + prognosis following conservative therapy. Recurrences are infrequent, and metastasis + is rare. + termDef: + term: >- + Atypical Fibroxanthoma + source: NCIt + cde_id: C4246 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4246" + term_id: C4246 + term_version: 20.05a + +"88303": + common: + description: >- + An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic + malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma. + termDef: + term: >- + Undifferentiated Pleomorphic Sarcoma + source: NCIt + cde_id: C4247 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4247" + term_id: C4247 + term_version: 20.05a + +"88310": + common: + description: >- + A mesenchymal tumor composed of fibroblastic and histiocytic cells. + termDef: + term: >- + Histiocytoma + source: NCIt + cde_id: 'C35765 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35765 " + term_id: 'C35765 ' + term_version: 20.05a + +"88320": + common: + description: >- + A solitary, slowly growing, nodular tumor most often affecting the extremities. + It is composed of fibrous and histiocytic cells which infiltrate the dermis + and occasionally the underlying subcutaneous tissue. Usually local excision + is curative. Recurrences are reported only in a small minority of cases. + termDef: + term: >- + Skin Fibrous Histiocytoma + source: NCIt + cde_id: 'C6801 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6801 " + term_id: 'C6801 ' + term_version: 20.05a + +"88323": + common: + description: >- + A low grade fibroblastic neoplasm presenting as a nodular cutaneous mass, most + often on the trunk and the proximal extremities. The tumor diffusely infiltrates + the dermis and the subcutaneous tissues. It is considered a locally aggressive + neoplasm, which often recurs but rarely metastasizes. + termDef: + term: >- + Dermatofibrosarcoma Protuberans + source: NCIt + cde_id: C4683 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4683" + term_id: C4683 + term_version: 20.05a + +"88333": + common: + description: >- + A morphologic variant of dermatofibrosarcoma protuberans characterized by the + presence of melanin-pigmented dendritic cells. + termDef: + term: >- + Pigmented Dermatofibrosarcoma Protuberans + source: NCIt + cde_id: C9430 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9430" + term_id: C9430 + term_version: 20.05a + +"88341": + common: + description: >- + A rare, locally aggressive fibroblastic neoplasm typically affecting young patients + (predominantly boys). It manifests with painless nodules in the dermis or subcutaneous + tissues. Morphologically, it contains giant cells and wide vessel-like spaces. This + tumor can recur but metastases have not been reported. + termDef: + term: >- + Giant Cell Fibroblastoma + source: NCIt + cde_id: C4700 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4700" + term_id: C4700 + term_version: 20.05a + +"88351": + common: + description: >- + An intermediate fibrohistiocytic neoplasm of the skin that usually affects children + and young adults. It is a multinodular, poorly circumscribed tumor characterized + by the presence of multinucleated giant cells, mononuclear histiocyte-like cells, + and spindle fibroblast-like cells arranged in a plexiform pattern. + termDef: + term: >- + Plexiform Fibrohistiocytic Tumor + source: NCIt + cde_id: C6493 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6493" + term_id: C6493 + term_version: 20.05a + +"88361": + common: + description: >- + A low malignant potential soft tissue neoplasm of uncertain differentiation. It + typically affects young patients, presenting as a slowly growing nodular or + cystic tumor mass, most often in the subcutaneous tissues of the extremities. Occasionally, + patients have systemic symptoms (anemia, fever, and weight loss). This tumor + has a relatively good prognosis. A minority of patients develop local recurrences. Metastases + are rare. + termDef: + term: >- + Angiomatoid Fibrous Histiocytoma + source: NCIt + cde_id: C6494 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6494" + term_id: C6494 + term_version: 20.05a + +"88400": + common: + description: >- + A benign soft tissue neoplasm characterized by the presence of spindle and stellate + cells, lobulated growth pattern, and myxoid stroma formation. + termDef: + term: >- + Myxoma + source: NCIt + cde_id: C6577 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6577" + term_id: C6577 + term_version: 20.05a + +"88403": + common: + description: >- + An infiltrating malignant soft tissue neoplasm characterized by the presence + of immature undifferentiated cells and abundant myxoid stroma formation. + termDef: + term: >- + Myxosarcoma + source: NCIt + cde_id: C3255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3255" + term_id: C3255 + term_version: 20.05a + +"88411": + common: + description: >- + A benign soft tissue neoplasm characterized by the presence of neoplastic spindle + and stellate cells in a myxoid stroma. + termDef: + term: >- + Angiomyxoma + source: NCIt + cde_id: 'C3254 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3254 " + term_id: 'C3254 ' + term_version: 20.05a + +"88420": + common: + description: >- + A rare soft tissue tumor of uncertain lineage characterized by the presence + of neoplastic spindle to round cells forming cords in a fibromyxoid stroma. The + lesions are associated with the formation of metaplastic bone. Most patients + present with painless subcutaneous masses. Recurrences have been reported in + a minority of patients. + termDef: + term: >- + Ossifying Fibromyxoid Tumor + source: NCIt + cde_id: C6582 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6582" + term_id: C6582 + term_version: 20.05a + +"88423": + common: + description: >- + A sarcoma that arises from the lung. It is related to a bronchus and is often + predominantly endobronchial. It is characterized by the proliferation of round + and spindle cells within a myxoid stroma. It is associated with the presence + of an EWSR1-CREB1 fusion gene. + termDef: + term: >- + Pulmonary Myxoid Sarcoma with EWSR1-CREB1 Translocation + source: NCIt + cde_id: C142827 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142827" + term_id: C142827 + term_version: 20.05a + +"88500": + common: + description: >- + A benign, usually painless, well-circumscribed lipomatous tumor composed of + adipose tissue. + termDef: + term: >- + Lipoma + source: NCIt + cde_id: C3192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3192" + term_id: C3192 + term_version: 20.05a + +"88501": + common: + description: >- + An intermediate, locally aggressive lipomatous neoplasm. Microscopically, the + adipose tissue contains large and pleomorphic lipoblasts, and is dissected by + fibrous septa containing spindle cells. It requires a wide local excision, + may recur locally, but never metastasizes. + termDef: + term: >- + Atypical Lipomatous Tumor + source: NCIt + cde_id: C6505 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6505" + term_id: C6505 + term_version: 20.05a + +"88503": + common: + description: >- + A usually painless malignant tumor that arises from adipose tissue. Microscopically, + it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to + pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, + dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential + is higher in less differentiated tumors. + termDef: + term: >- + Liposarcoma + source: NCIt + cde_id: C3194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3194" + term_id: C3194 + term_version: 20.05a + +"88510": + common: + description: >- + A benign well-circumscribed tumor composed of mature adipocytes, characterized + by areas of abundant fibrous tissue. + termDef: + term: >- + Fibrolipoma + source: NCIt + cde_id: C4249 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4249" + term_id: C4249 + term_version: 20.05a + +"88513": + common: + description: >- + A locally aggressive malignant neoplasm composed of mature adipocytes showing + cell size variation and nuclear atypia. It is often associated with the presence + of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. + There are three histologic subtypes, sclerosing, inflammatory, and spindle cell + liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation. + termDef: + term: >- + Well Differentiated Liposarcoma + source: NCIt + cde_id: 'C4250 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4250 " + term_id: 'C4250 ' + term_version: 20.05a + +"88520": + common: + description: >- + A benign well-circumscribed tumor composed of mature adipocytes, characterized + by areas of abundant fibrous tissue and extensive myxoid change. + termDef: + term: >- + Fibromyxolipoma + source: NCIt + cde_id: C4251 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4251" + term_id: C4251 + term_version: 20.05a + +"88523": + common: + description: >- + A liposarcoma characterized by the presence of round non-lipogenic primitive + mesenchymal cells and small signet ring lipoblasts within a myxoid stoma with + a branching vascular pattern. This category includes hypercellular lesions + with round cell morphology, formerly known as round cell liposarcoma. + termDef: + term: >- + Myxoid Liposarcoma + source: NCIt + cde_id: C27781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27781" + term_id: C27781 + term_version: 20.05a + +"88533": + common: + description: >- + A poorly differentiated liposarcoma, characterized by the presence of solid + sheets of primitive round mesenchymal cells and the absence of myxoid stroma. + termDef: + term: >- + Round Cell Liposarcoma + source: NCIt + cde_id: C4252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4252" + term_id: C4252 + term_version: 20.05a + +"88540": + common: + description: >- + A benign circumscribed tumor characterized by small spindle cells, rounded hyperchromatic + cells and multinucleated giant cells with radially arranged nuclei. + termDef: + term: >- + Pleomorphic Lipoma + source: NCIt + cde_id: C3703 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3703" + term_id: C3703 + term_version: 20.05a + +"88543": + common: + description: >- + A liposarcoma characterized by the presence of varying proportions of pleomorphic + lipoblasts in a background that resembles undifferentiated pleomorphic sarcoma. It + is the rarest liposarcoma variant and usually has an aggressive clinical course. + termDef: + term: >- + Pleomorphic Liposarcoma + source: NCIt + cde_id: C3705 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3705" + term_id: C3705 + term_version: 20.05a + +"88553": + common: + description: >- + A malignant neoplasm characterized by the presence of a combination of liposarcomatous + morphologic subtypes: myxoid/round cell and well differentiated/dedifferentiated + liposarcoma or myxoid/round cell and pleomorphic liposarcoma. + termDef: + term: >- + Mixed Liposarcoma + source: NCIt + cde_id: C4253 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4253" + term_id: C4253 + term_version: 20.05a + +"88560": + common: + description: >- + A benign tumor, composed of mature adipocytes, that arises within skeletal muscle + fibers. + termDef: + term: >- + Intramuscular Lipoma + source: NCIt + cde_id: 'C7450 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7450 " + term_id: 'C7450 ' + term_version: 20.05a + +"88570": + common: + description: >- + A benign circumscribed tumor composed of spindled cells, adipocytes, and collagen + bundles. There is no evidence of nuclear hyperchromasia or mitotic activity. + termDef: + term: >- + Spindle Cell Lipoma + source: NCIt + cde_id: C4254 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4254" + term_id: C4254 + term_version: 20.05a + +"88573": + common: + description: >- + A liposarcoma characterized by the presence of a fibroblastic component. + termDef: + term: >- + Fibroblastic Liposarcoma + source: NCIt + cde_id: C6509 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6509" + term_id: C6509 + term_version: 20.05a + +"88583": + common: + description: >- + An atypical lipomatous tumor/well differentiated liposarcoma that shows progression + to a usually non-lipomatous, high grade sarcoma. The non-lipomatous sarcoma + component may be present in the primary lesion or at the site of recurrence. + termDef: + term: >- + Dedifferentiated Liposarcoma + source: NCIt + cde_id: C3704 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3704" + term_id: C3704 + term_version: 20.05a + +"88600": + common: + description: >- + A neoplasm with perivascular epithelioid cell differentiation often associated + with tuberous sclerosis. It is characterized by a mixture of epithelioid cells, + smooth muscle, vessels, and mature adipose tissue. The kidney is the most common + site of involvement. Other sites of involvement include the liver, lung, lymph + nodes, and retroperitoneum. The vast majority of cases follow a benign clinical + course. However, cases of metastatic angiomyolipomas with sarcomatoid features + have been described. + termDef: + term: >- + Angiomyolipoma + source: NCIt + cde_id: C3734 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3734" + term_id: C3734 + term_version: 20.05a + +"88610": + common: + description: >- + A lipoma with prominent vascularity. The vascular tissue is more abundant at + the periphery of the tumor and contains fibrin thrombi. It occurs more frequently + in younger individuals as a painful subcutaneous nodule, often on the arms. + termDef: + term: >- + Angiolipoma + source: NCIt + cde_id: C3733 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3733" + term_id: C3733 + term_version: 20.05a + +"88620": + common: + description: >- + A rare benign adipose tissue neoplasm characterized by nests and cord of abundant + univacuolated and multivacuolated lipoblasts and mature adipocytes in a prominent + myxoid to hyalinized chondroid matrix admix. It predominantly affects females. + termDef: + term: >- + Chondroid Lipoma + source: NCIt + cde_id: C6503 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6503" + term_id: C6503 + term_version: 20.05a + +"88700": + common: + description: >- + A benign soft tissue lesion arising from the adrenal gland. It is composed + of mature adipose and hematopoietic/lymphoid tissues. + termDef: + term: >- + Adrenal Gland Myelolipoma + source: NCIt + cde_id: C3736 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3736" + term_id: C3736 + term_version: 20.05a + +"88800": + common: + description: >- + A rare benign slow growing adipose tissue tumor, characterized by the presence + of polygonal brown fat cells with multivacuolated and/or granular cytoplasm. The + tumor is usually painless and is most often seen in young adults. + termDef: + term: >- + Hibernoma + source: NCIt + cde_id: C3702 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3702" + term_id: C3702 + term_version: 20.05a + +"88810": + common: + description: >- + A benign disorder characterized by the presence of multiple lipoblastomas. + termDef: + term: >- + Lipoblastomatosis + source: NCIt + cde_id: 'C4255 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4255 " + term_id: 'C4255 ' + term_version: 20.05a + +"88900": + common: + description: >- + A well-circumscribed benign smooth muscle neoplasm characterized by the presence + of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled + pattern. + termDef: + term: >- + Leiomyoma + source: NCIt + cde_id: 'C3157 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3157 " + term_id: 'C3157 ' + term_version: 20.05a + +"88901": + common: + description: >- + A condition characterized by the presence of numerous small benign smooth muscle + neoplasms located throughout the body. + termDef: + term: >- + Leiomyomatosis + source: NCIt + cde_id: C3748 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3748" + term_id: C3748 + term_version: 20.05a + +"88903": + common: + description: >- + An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring + in post-menopausal women. It is characterized by a proliferation of neoplastic + spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory + and myxoid leimyosarcomas. + termDef: + term: >- + Leiomyosarcoma + source: NCIt + cde_id: C3158 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3158" + term_id: C3158 + term_version: 20.05a + +"88910": + common: + description: >- + A benign or malignant gastrointestinal stromal tumor with epithelioid morphology. + termDef: + term: >- + Epithelioid Cell Type Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C3486 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3486" + term_id: C3486 + term_version: 20.05a + +"88913": + common: + description: >- + A morphologic variant of leiomyosarcoma characterized by the presence of epithelioid + round cells with eosinophilic to clear cytoplasm. + termDef: + term: >- + Epithelioid Leiomyosarcoma + source: NCIt + cde_id: C3700 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3700" + term_id: C3700 + term_version: 20.05a + +"88920": + common: + description: >- + A morphologic variant of classic leiomyoma characterized by a dense cellular + infiltrate composed of spindle or round cells with scant cytoplasm and a less + obvious interlacing fascicle pattern. + termDef: + term: >- + Cellular Leiomyoma + source: NCIt + cde_id: C4256 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4256" + term_id: C4256 + term_version: 20.05a + +"88930": + common: + description: >- + A morphologic variant of leiomyoma characterized by the presence of pleomorphic + muscle cells with bizarre hyperchromatic nuclei and eosinophilic cytoplasm. + termDef: + term: >- + Bizarre Leiomyoma + source: NCIt + cde_id: C4257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4257" + term_id: C4257 + term_version: 20.05a + +"88940": + common: + description: >- + A benign, slow-growing neoplasm that arises from the dermis or subcutaneous + tissue. It is characterized by the presence of well-differentiated smooth muscle + cells which are arranged around numerous vessels. + termDef: + term: >- + Angioleiomyoma + source: NCIt + cde_id: C3747 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3747" + term_id: C3747 + term_version: 20.05a + +"88943": + common: + description: >- + A malignant smooth muscle neoplasm characterized by the presence of atypical + spindle cells and formation of vascular channels. + termDef: + term: >- + Angiomyosarcoma + source: NCIt + cde_id: C66771 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66771" + term_id: C66771 + term_version: 20.05a + +"88950": + common: + description: >- + A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle + tissue. + termDef: + term: >- + Benign Muscle Neoplasm + source: NCIt + cde_id: C4882 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4882" + term_id: C4882 + term_version: 20.05a + +"88953": + common: + description: >- + A malignant neoplasm affecting the skeletal or smooth muscles. Malignant neoplasms + arising from the skeletal muscles are called rhabdomyosarcomas. Malignant neoplasms + arising from the smooth muscles are called leiomyosarcomas. + termDef: + term: >- + Malignant Muscle Neoplasm + source: NCIt + cde_id: C4883 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4883" + term_id: C4883 + term_version: 20.05a + +"88963": + common: + description: >- + A morphologic variant of leiomyosarcoma characterized by the presence of cellular + pleomorphism, malignant cells with large nuclei, and a myxoid stroma. + termDef: + term: >- + Myxoid Leiomyosarcoma + source: NCIt + cde_id: C3701 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3701" + term_id: C3701 + term_version: 20.05a + +"88971": + common: + description: >- + A benign or malignant myomatous neoplasm arising from smooth muscle. + termDef: + term: >- + Smooth Muscle Neoplasm + source: NCIt + cde_id: C3751 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3751" + term_id: C3751 + term_version: 20.05a + +"89000": + common: + description: >- + A benign mesenchymal tumor arising from skeletal or cardiac muscle. + termDef: + term: >- + Rhabdomyoma + source: NCIt + cde_id: C3358 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3358" + term_id: C3358 + term_version: 20.05a + +"89003": + common: + description: >- + A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. + It usually occurs in children and young adults. Only a small percentage of tumors + arise in the skeletal muscle of the extremities. The majority arise in other + anatomic sites. + termDef: + term: >- + Rhabdomyosarcoma + source: NCIt + cde_id: C3359 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3359" + term_id: C3359 + term_version: 20.05a + +"89013": + common: + description: >- + An aggressive rhabdomyosarcoma occurring in adults. The neoplasm is characterized + by the presence of bizarre round, spindle, and polygonal cells. Clinical presentation + includes a rapidly enlarging painful mass usually in the lower extremities. + termDef: + term: >- + Adult Pleomorphic Rhabdomyosarcoma + source: NCIt + cde_id: 'C27369 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27369 " + term_id: 'C27369 ' + term_version: 20.05a + +"89030": + common: + description: >- + A rare benign mesenchymal neoplasm arising from skeletal muscle. It is characterized + by the presence of immature spindle and polygonal cells within a scant myxoid + stroma. It usually develops in the head and neck region of young children. + termDef: + term: >- + Fetal Rhabdomyoma + source: NCIt + cde_id: C4260 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4260" + term_id: C4260 + term_version: 20.05a + +"89050": + common: + description: >- + A rare benign skeletal muscle neoplasm arising from the female genital tract. + It is characterized by the presence of small nucleated rhabdomyoblasts within + a fibrous and myxoid stroma. + termDef: + term: >- + Genital Rhabdomyoma + source: NCIt + cde_id: C6517 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6517" + term_id: C6517 + term_version: 20.05a + +"89103": + common: + description: >- + A poorly circumscribed morphologic variant of rhabdomyosarcoma. It is characterized + by the presence of primitive skeletal muscle differentiation in any stage of + myogenesis. + termDef: + term: >- + Embryonal Rhabdomyosarcoma + source: NCIt + cde_id: 'C8971 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8971 " + term_id: 'C8971 ' + term_version: 20.05a + +"89123": + common: + description: >- + An uncommon variant of rhabdomyosarcoma characterized by the presence of whorls + of spindle cells forming a storiform pattern. In children it usually arises + in the paratesticular region. In adults it usually arises from the deep soft + tissues in the head and neck. + termDef: + term: >- + Spindle Cell Rhabdomyosarcoma + source: NCIt + cde_id: C6519 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6519" + term_id: C6519 + term_version: 20.05a + +"89203": + common: + description: >- + A rapidly growing malignant mesenchymal neoplasm. It is characterized by the + presence of round cells with myoblastic differentiation and a fibrovascular + stroma resembling an alveolar growth pattern. The tumor usually presents in + the extremities. + termDef: + term: >- + Alveolar Rhabdomyosarcoma + source: NCIt + cde_id: C3749 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3749" + term_id: C3749 + term_version: 20.05a + +"89213": + common: + description: >- + An aggressive malignant mesenchymal neoplasm of the nervous system or soft tissues. + It is characterized by the presence of a sarcomatous component (most often rhabdomyosarcoma) + and a ganglionic or a neuroectodermal component. + termDef: + term: >- + Ectomesenchymoma + source: NCIt + cde_id: C4716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4716" + term_id: C4716 + term_version: 20.05a + +"89300": + common: + description: >- + A non-infiltrating, benign mesenchymal neoplasm arising from the uterine corpus. + It is characterized by the presence of neoplastic cells that resemble the cells + of the proliferative phase of endometrial stroma and numerous thin-walled small + vessels. It usually presents with abnormal uterine bleeding and menorrhagia. + termDef: + term: >- + Endometrial Stromal Nodule + source: NCIt + cde_id: C4262 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4262" + term_id: C4262 + term_version: 20.05a + +"89303": + common: + description: >- + A malignant mesenchymal neoplasm that affects the uterine corpus, and rarely, + the ovaries, cervix, and vagina. In the uterine corpus it is classified as low + grade or high grade endometrial stromal sarcoma. In the remainder of the anatomic + sites it is classified as low grade endometrioid stromal sarcoma. + termDef: + term: >- + Endometrioid Stromal Sarcoma + source: NCIt + cde_id: 'C8973 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8973 " + term_id: 'C8973 ' + term_version: 20.05a + +"89313": + common: + description: >- + An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, + and the ovary. It is characterized by the presence of oval to spindle-shape + cells that resemble the cells of the endometrial stroma, without evidence of + significant atypia and pleomorphism. Numerous small vessels are also present. + It is usually characterized by indolent growth and late recurrences. + termDef: + term: >- + Low Grade Endometrioid Stromal Sarcoma + source: NCIt + cde_id: C4263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4263" + term_id: C4263 + term_version: 20.05a + +"89320": + common: + description: >- + A benign neoplasm characterized by the presence of a glandular and a mesenchymal + (fibromyomatous) component. It occurs in the uterine corpus and the cervix. + A variant of adenomyoma associated with glandular architectural complexity is + called atypical polypoid adenomyoma. Simple polypectomy is usually curative. + Atypical polypoid adenomyoma may recur following polypectomy. + termDef: + term: >- + Adenomyoma + source: NCIt + cde_id: 'C3726 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3726 " + term_id: 'C3726 ' + term_version: 20.05a + +"89333": + common: + description: >- + A low grade malignant neoplasm characterized by the presence of a benign epithelial + component (tubular and cleft-like glands) and a low grade sarcomatous component + that contains varying amounts of fibrous and smooth muscle tissues. In a minority + of cases, the sarcomatous component contains heterologous elements including + striated muscle, cartilage, and fat. It occurs in the uterine corpus, ovary, + fallopian tube, cervix, and vagina. It may recur and in a minority of cases + may metastasize to distant anatomic sites. + termDef: + term: >- + Adenosarcoma + source: NCIt + cde_id: C9474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9474" + term_id: C9474 + term_version: 20.05a + +"89350": + common: + description: >- + A benign neoplasm composed of mesenchymal stromal cells without evidence of + cellular atypia. + termDef: + term: >- + Benign Stromal Tumor + source: NCIt + cde_id: C66772 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66772" + term_id: C66772 + term_version: 20.05a + +"89351": + common: + description: >- + A benign or malignant mesenchymal neoplasm composed of stromal cells. Representative + examples include gastrointestinal stromal tumor, endometrial stromal sarcoma, + and prostate stromal sarcoma. + termDef: + term: >- + Stromal Neoplasm + source: NCIt + cde_id: C6781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6781" + term_id: C6781 + term_version: 20.05a + +"89353": + common: + description: >- + A malignant neoplasm characterized by the presence of atypical mesenchymal-stromal + cells. Representative examples include endometrial stromal sarcoma and prostate + stromal sarcoma. + termDef: + term: >- + Stromal Sarcoma + source: NCIt + cde_id: C6926 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6926" + term_id: C6926 + term_version: 20.05a + +"89360": + common: + description: >- + Low Risk Gastrointestinal Stromal Tumor + termDef: + term: >- + Low Risk Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C27242 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27242" + term_id: C27242 + term_version: 20.05a + +"89361": + common: + description: >- + A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases + of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal + gastrointestinal stromal tumor). It is a tumor that differentiates along the + lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating + mutations. Until recently, surgery has been the only effective therapy for this + tumor. However, many patients still experience recurrence. Conventional chemotherapy + and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, + imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the + treatment of relapsed and unresectable cases. + termDef: + term: >- + Gastrointestinal Stromal Tumor + source: NCIt + cde_id: 'C3868 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3868 " + term_id: 'C3868 ' + term_version: 20.05a + +"89363": + common: + description: >- + High Risk Gastrointestinal Stromal Tumor + termDef: + term: >- + High Risk Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C27243 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27243" + term_id: C27243 + term_version: 20.05a + +"89400": + common: + description: >- + A neoplasm characterized by the presence of benign epithelial and myoepithelial + cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, + or osseous areas. It may be completely or partially encapsulated. It occurs + in the parotid gland, submandibular gland, minor salivary glands in the oral + cavity, upper respiratory tract, and nasal cavity and paranasal sinuses. It + usually presents as a slow growing painless mass. Infrequently, patients may + present with pain and facial palsy. It may recur after excision or transform + to a malignant neoplasm (carcinoma ex pleomorphic adenoma). + termDef: + term: >- + Pleomorphic Adenoma + source: NCIt + cde_id: 'C8602 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8602 " + term_id: 'C8602 ' + term_version: 20.05a + +"89403": + common: + description: >- + A malignant tumor arising from the salivary gland. It includes carcinoma ex + pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing + pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of + malignant epithelial and sarcomatous elements. + termDef: + term: >- + Malignant Mixed Tumor of the Salivary Gland + source: NCIt + cde_id: C8025 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8025" + term_id: C8025 + term_version: 20.05a + +"89413": + common: + description: >- + A carcinoma arising in a pre-existing pleomorphic adenoma. It most often occurs + in the parotid gland and less often in the submandibular gland and minor salivary + gland. Patients usually present with a history of a long-standing mass which + recently had undergone rapid growth. The prognosis depends on the invasiveness + of the malignant component. Patients with non-invasive or minimally invasive + tumors usually have a good prognosis following surgical resection. Invasive + tumors are usually aggressive and are associated with recurrences and metastases. + termDef: + term: >- + Carcinoma ex Pleomorphic Adenoma + source: NCIt + cde_id: C4397 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4397" + term_id: C4397 + term_version: 20.05a + +"89503": + common: + description: >- + A group of tumors affecting the female reproductive system, characterized by + the presence of epithelial and stromal elements. It includes the following clinicopathological + entities: adenofibroma, adenomyoma, Mullerian adenosarcoma, and malignant mixed + mesodermal (Mullerian) tumor. + termDef: + term: >- + Mixed Mesodermal (Mullerian) Tumor + source: NCIt + cde_id: C3730 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3730" + term_id: C3730 + term_version: 20.05a + +"89513": + common: + description: >- + A group of tumors affecting the female reproductive system, characterized by + the presence of epithelial and stromal elements. It includes the following clinicopathological + entities: adenofibroma, adenomyoma, Mullerian adenosarcoma, and malignant mixed + mesodermal (Mullerian) tumor. + termDef: + term: >- + Mixed Mesodermal (Mullerian) Tumor + source: NCIt + cde_id: C3730 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3730" + term_id: C3730 + term_version: 20.05a + +"89590": + common: + description: >- + A localized, well-circumscribed multilocular tumor lined by hobnail epithelium. + It was previously classified along with pediatric cystic nephroma, as a separate + entity from mixed epithelial and stromal tumors. Now it is classified within + the spectrum of the mixed epithelial and stromal tumor family. Most of these + tumors are benign. (WHO 2016). + termDef: + term: >- + Adult Cystic Nephroma + source: NCIt + cde_id: C7504 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7504" + term_id: C7504 + term_version: 20.05a + +"89591": + common: + description: >- + A variant of Wilms tumor of the kidney characterized by the presence of cystic + spaces separated by septa. The septa contain immature epithelial cells, immature + stromal cells, and blastema cells. Surgical resection is usually curative. + termDef: + term: >- + Cystic Partially Differentiated Kidney Nephroblastoma + source: NCIt + cde_id: C6897 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6897" + term_id: C6897 + term_version: 20.05a + +"89593": + common: + description: >- + A variant of Wilms tumor of the kidney characterized by the presence of cystic + spaces separated by septa. The septa contain immature epithelial cells, immature + stromal cells, and blastema cells. Surgical resection is usually curative. + termDef: + term: >- + Cystic Partially Differentiated Kidney Nephroblastoma + source: NCIt + cde_id: C6897 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6897" + term_id: C6897 + term_version: 20.05a + +"89603": + common: + description: >- + An embryonal pediatric tumor of the kidney which may also be seen rarely in + adults. The peak incidence of Wilms tumor is between the second and fifth year + of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, + stromal, and epithelial). The most common sites of metastasis include the regional + lymph nodes, lungs, and liver. + termDef: + term: >- + Kidney Wilms Tumor + source: NCIt + cde_id: 'C40407 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40407 " + term_id: 'C40407 ' + term_version: 20.05a + +"89633": + common: + description: >- + An aggressive malignant embryonal neoplasm usually occurring during childhood. It + is characterized by the presence of large cells with abundant cytoplasm, large + eccentric nucleus, and a prominent nucleolus and it is associated with abnormalities + of chromosome 22. It can arise from the central nervous system, kidney, and + the soft tissues. The prognosis is poor. + termDef: + term: >- + Rhabdoid Tumor + source: NCIt + cde_id: C3808 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3808" + term_id: C3808 + term_version: 20.05a + +"89643": + common: + description: >- + A rare pediatric sarcoma affecting the kidney. It is characterized by the presence + of epithelioid or spindle cells forming cords or nests, separated by fibrovascular + septa. It is associated with internal tandem duplications in the BCOR gene. + It metastasizes to lung, bone, brain and soft tissue. + termDef: + term: >- + Clear Cell Sarcoma of the Kidney + source: NCIt + cde_id: C4264 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4264" + term_id: C4264 + term_version: 20.05a + +"89650": + common: + description: >- + A benign, solitary, and partially cystic neoplasm arising from the kidney. It + occurs in children and adults. Presenting symptoms include hematuria and polycythemia. + It is characterized by the presence of epithelial nodules embedded in a stroma + containing spindle cells. + termDef: + term: >- + Metanephric Adenofibroma + source: NCIt + cde_id: C39812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39812" + term_id: C39812 + term_version: 20.05a + +"89703": + common: + description: >- + A malignant liver neoplasm that occurs almost exclusively in infants, although + isolated cases in older children and adults have been reported. Grossly, hepatoblastoma + is solid, well circumscribed, and more often solitary than multiple. Microscopically, + most of the tumors are composed exclusively of immature hepatocytic elements. + About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated + or develop into bone or cartilage. The treatment of choice for hepatoblastoma + is surgical excision with adjuvant therapy. Liver transplantation is being increasingly + used as well. + termDef: + term: >- + Hepatoblastoma + source: NCIt + cde_id: 'C3728 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3728 " + term_id: 'C3728 ' + term_version: 20.05a + +"89713": + common: + description: >- + A rare malignant epithelial neoplasm arising from the pancreas. The vast majority + of cases occur during childhood. It is characterized by acinar differentiation, + the formation of squamoid corpuscles, and the formation of stromal bands. Patients + may present with an abdominal mass. Symptoms include pain, weight loss, and + diarrhea. It may metastasize to lymph nodes, liver, and distant anatomic sites. + Children who do not have metastatic disease at the time of diagnosis usually + have a favorable clinical outcome when treated with a combination of surgery + and chemotherapy. However, children with metastatic disease at presentation + or adult patients usually have a poor prognosis. + termDef: + term: >- + Pancreatoblastoma + source: NCIt + cde_id: C4265 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4265" + term_id: C4265 + term_version: 20.05a + +"89723": + common: + description: >- + A biphasic tumor that consists of fetal adenocarcinoma (typically low-grade) + and primitive mesenchymal stroma. Foci of specific mesenchymal differentiation + (osteosarcoma, chondrosarcoma, or rhabdomyosarcoma) may also be present, but + are not required for the diagnosis. Most patients are smokers. The prognosis + is very poor. (WHO 2015) + termDef: + term: >- + Pulmonary Blastoma + source: NCIt + cde_id: C3732 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3732" + term_id: C3732 + term_version: 20.05a + +"89733": + common: + description: >- + A malignant neoplasm affecting the lungs and/or the pleura. Pleuropulmonary + blastoma is seen in children. Microscopically, the tumor may show features of + chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated + sarcoma. In approximately 25% of patients with pleuropulmonary blastoma, there + are other lesions or neoplasms that may affect patients or their families, including + lung or kidney cysts, and ovarian or testicular neoplasms. Heterozygous germline + mutations in DICER1 gene have been identified in families harboring pleuropulmonary + blastomas. + termDef: + term: >- + Pleuropulmonary Blastoma + source: NCIt + cde_id: C5669 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5669" + term_id: C5669 + term_version: 20.05a + +"89803": + common: + description: >- + A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. + termDef: + term: >- + Carcinosarcoma + source: NCIt + cde_id: C34448 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C34448" + term_id: C34448 + term_version: 20.05a + +"89820": + common: + description: >- + A benign or malignant tumor characterized by the presence of cells that show + myoepithelial differentiation. Based on its morphologic features, it is classified + as benign or malignant. A representative example of benign myoepithelioma is + benign salivary gland myoepithelioma. Representative examples of malignant myoepithelioma + or myoepithelial carcinoma are malignant breast myoepithelioma and salivary + gland myoepithelial carcinoma. + termDef: + term: >- + Myoepithelial Tumor + source: NCIt + cde_id: 'C40392 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40392 " + term_id: 'C40392 ' + term_version: 20.05a + +"89823": + common: + description: >- + An infiltrating malignant tumor characterized by the presence of atypical cells + with myoepithelial differentiation. Representative examples include malignant + breast myoepithelioma and salivary gland myoepithelial carcinoma. + termDef: + term: >- + Malignant Myoepithelioma + source: NCIt + cde_id: C7596 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7596" + term_id: C7596 + term_version: 20.05a + +"89900": + common: + description: >- + A term describing a benign soft tissue tumor which consists of two or more mesenchymal + lines of differentiation, excluding a fibroblastic line of differentiation. + termDef: + term: >- + Benign Mesenchymoma + source: NCIt + cde_id: C4267 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4267" + term_id: C4267 + term_version: 20.05a + +"89901": + common: + description: >- + A term describing a soft tissue tumor which consists of two or more mesenchymal + lines of differentiation, excluding a fibroblastic line of differentiation. + termDef: + term: >- + Mesenchymoma + source: NCIt + cde_id: C3233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3233" + term_id: C3233 + term_version: 20.05a + +"89903": + common: + description: >- + A term describing a malignant soft tissue tumor which consists of two or more + mesenchymal lines of differentiation, excluding a fibroblastic line of differentiation. + termDef: + term: >- + Malignant Mesenchymoma + source: NCIt + cde_id: C4268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4268" + term_id: C4268 + term_version: 20.05a + +"89913": + common: + description: >- + An aggressive malignant mesenchymal neoplasm that arises from the liver and + usually occurs in older children. It is composed of immature spindle, stellate, + polymorphous, and giant cells. + termDef: + term: >- + Undifferentiated (Embryonal) Sarcoma + source: NCIt + cde_id: C27096 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27096" + term_id: C27096 + term_version: 20.05a + +"90000": + common: + description: >- + A usually benign tumor composed of solid and cystic nests of epithelial cells + resembling transitional epithelium; it is surrounded by an abundant stromal + component that is dense and fibroblastic in nature. + termDef: + term: >- + Brenner Tumor + source: NCIt + cde_id: C39954 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39954" + term_id: C39954 + term_version: 20.05a + +"90001": + common: + description: >- + A transitional cell neoplasm of low malignant potential arising from the ovary. It + is characterized by the presence of neoplastic transitional cells with atypical + or malignant features without evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Brenner Tumor/Atypical Proliferative Ovarian Brenner Tumor + source: NCIt + cde_id: C9459 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9459" + term_id: C9459 + term_version: 20.05a + +"90003": + common: + description: >- + A malignant neoplasm that arises from the ovary and is characterized by the + presence of an invasive malignant transitional cell component and nests of benign + transitional cells in a fibrotic stroma. When the neoplasm is confined to the + ovary, the prognosis is good. + termDef: + term: >- + Malignant Ovarian Brenner Tumor + source: NCIt + cde_id: C4270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4270" + term_id: C4270 + term_version: 20.05a + +"90100": + common: + description: >- + A benign tumor of the breast characterized by the presence of stromal and epithelial + elements. It presents as a painless, solitary, slow growing, firm, and mobile + mass. It is the most common benign breast lesion. It usually occurs in women + of childbearing age. The majority of fibroadenomas do not recur after complete + excision. A slightly increased risk of developing cancer within fibroadenomas + or in the breast tissue of patients previously treated for fibroadenomas has + been reported. + termDef: + term: >- + Breast Fibroadenoma + source: NCIt + cde_id: C3744 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3744" + term_id: C3744 + term_version: 20.05a + +"90110": + common: + description: >- + A morphologic variant of breast fibroadenoma without clinical significance. + It is characterized by distortion and compression of the ducts by proliferating + stromal cells. + termDef: + term: >- + Breast Intracanalicular Fibroadenoma + source: NCIt + cde_id: C4271 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4271" + term_id: C4271 + term_version: 20.05a + +"90120": + common: + description: >- + A morphologic variant of breast fibroadenoma without clinical significance. + It is characterized by circumferential proliferation of stromal cells around + the ducts. This results in the formation of rounded ductal-epithelial structures. + termDef: + term: >- + Breast Pericanalicular Fibroadenoma + source: NCIt + cde_id: C4272 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4272" + term_id: C4272 + term_version: 20.05a + +"90130": + common: + description: >- + A benign or borderline neoplasm characterized by the presence of connective + tissue stroma and epithelial structures. It occurs in the ovary, fallopian tube, + uterine corpus, and cervix. + termDef: + term: >- + Female Reproductive System Adenofibroma + source: NCIt + cde_id: 'C8984 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8984 " + term_id: 'C8984 ' + term_version: 20.05a + +"90140": + common: + description: >- + A benign or borderline adenofibroma characterized by the presence of serous + secretory cells and minute cystic spaces filled with watery fluid. A representative + example is the ovarian serous adenofibroma. + termDef: + term: >- + Serous Adenofibroma + source: NCIt + cde_id: C67090 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67090" + term_id: C67090 + term_version: 20.05a + +"90150": + common: + description: >- + A benign or borderline adenofibroma characterized by the presence of epithelial + cells which contain intracytoplasmic mucin and a fibrotic stroma. A representative + example is the ovarian mucinous adenofibroma. + termDef: + term: >- + Mucinous Adenofibroma + source: NCIt + cde_id: 'C8978 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8978 " + term_id: 'C8978 ' + term_version: 20.05a + +"90160": + common: + description: >- + A breast fibroadenoma characterized by a very large size. This term has also + been used as a synonym for juvenile fibroadenoma by some authors. The latter + is characterized by epithelial hyperplasia and an increased stromal cellularity. + termDef: + term: >- + Breast Giant Fibroadenoma + source: NCIt + cde_id: C4273 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4273" + term_id: C4273 + term_version: 20.05a + +"90200": + common: + description: >- + A benign, circumscribed fibroepithelial neoplasm arising from the breast and + rarely the prostate gland. It is characterized by the presence of epithelial + structures which are arranged in clefts and by a hypercellular mesenchymal stroma + which is organized in leaf-like structures. There is no evidence of cellular + atypia or sarcomatous features. + termDef: + term: >- + Benign Phyllodes Tumor + source: NCIt + cde_id: C4274 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4274" + term_id: C4274 + term_version: 20.05a + +"90201": + common: + description: >- + A phyllodes tumor with morphologic characteristics which are intermediate between + a benign and a malignant phyllodes tumor. The stromal sarcomatous changes are + of low grade and are often reminiscent of low grade fibrosarcomas. + termDef: + term: >- + Borderline Phyllodes Tumor + source: NCIt + cde_id: 'C7503 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7503 " + term_id: 'C7503 ' + term_version: 20.05a + +"90203": + common: + description: >- + A phyllodes tumor with sarcomatous stroma. The sarcomatous component is usually + of the fibrosarcomatous type. Liposarcomatous, chondrosarcomatous, osteosarcomatous, + or rhabdomyosarcomatous differentiation may also occur in the stroma. It may + recur and metastasize following surgical resection. The lung and skeleton are + the anatomic sites most frequently involved by metastases. + termDef: + term: >- + Malignant Phyllodes Tumor + source: NCIt + cde_id: C4275 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4275" + term_id: C4275 + term_version: 20.05a + +"90300": + common: + description: >- + A breast fibroadenoma characterized by epithelial hyperplasia and an increased + stromal cellularity. + termDef: + term: >- + Breast Juvenile Fibroadenoma + source: NCIt + cde_id: C4276 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4276" + term_id: C4276 + term_version: 20.05a + +"90400": + common: + description: >- + A benign neoplasm arising from the synovial membrane. Examples include the + diffuse giant cell tumor of tendon sheath and localized giant cell tumor of + tendon sheath. + termDef: + term: >- + Benign Synovial Neoplasm + source: NCIt + cde_id: C3829 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3829" + term_id: C3829 + term_version: 20.05a + +"90403": + common: + description: >- + A malignant neoplasm characterized by the chromosomal translocation t(X;18)(p11;q11). It + can occur at any age, but mainly affects young adults, more commonly males. Although + any site can be affected, the vast majority of the cases arise in the deep soft + tissues of extremities, especially around the knee. Microscopically, synovial + sarcoma is classified as monophasic (with a spindle or epithelial cell component) + or biphasic (with both spindle and epithelial cell components). Synovial sarcomas + can recur or metastasize to the lungs, bones, and lymph nodes. + termDef: + term: >- + Synovial Sarcoma + source: NCIt + cde_id: C3400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3400" + term_id: C3400 + term_version: 20.05a + +"90413": + common: + description: >- + A synovial sarcoma characterized by the presence of a spindle cell component + only. + termDef: + term: >- + Spindle Cell Synovial Sarcoma + source: NCIt + cde_id: C4277 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4277" + term_id: C4277 + term_version: 20.05a + +"90423": + common: + description: >- + A synovial sarcoma characterized by the presence of an epithelial cell component + only. The epithelial cells are arranged in glandular or papillary structures. + termDef: + term: >- + Epithelial Synovial Sarcoma + source: NCIt + cde_id: C4278 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4278" + term_id: C4278 + term_version: 20.05a + +"90433": + common: + description: >- + A synovial sarcoma characterized by the presence of both an epithelial and a + spindle cell component. + termDef: + term: >- + Biphasic Synovial Sarcoma + source: NCIt + cde_id: C4279 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4279" + term_id: C4279 + term_version: 20.05a + +"90443": + common: + description: >- + A rare malignant neoplasm with melanocytic differentiation characterized by + the presence of polygonal or spindle shaped clear cells. This sarcoma usually + affects the tendons and aponeuroses and is associated with a poor prognosis + due to recurrences and metastases. + termDef: + term: >- + Clear Cell Sarcoma of Soft Tissue + source: NCIt + cde_id: C3745 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3745" + term_id: C3745 + term_version: 20.05a + +"90500": + common: + description: >- + A benign neoplasm arising from mesothelial cells. It is characterized by the + formation of glandular and tubular patterns. It can occur in several anatomic + sites including the pleura, peritoneum, and epididymis. + termDef: + term: >- + Adenomatoid Tumor + source: NCIt + cde_id: C3762 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3762" + term_id: C3762 + term_version: 20.05a + +"90503": + common: + description: >- + A malignant neoplasm that arises from mesothelial cells. It is associated with + exposure to asbestos. + termDef: + term: >- + Malignant Mesothelioma + source: NCIt + cde_id: 'C4456 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4456 " + term_id: 'C4456 ' + term_version: 20.05a + +"90510": + common: + description: >- + A localized neoplasm of probable fibroblastic derivation, that arises from the + pleura. It is characterized by the presence of round to spindle-shaped cells, + hylanized stroma formation, thin-walled branching blood vessels, and thin bands + of collagen. + termDef: + term: >- + Pleural Solitary Fibrous Tumor + source: NCIt + cde_id: C4457 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4457" + term_id: C4457 + term_version: 20.05a + +"90513": + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of spindle cells. Anaplastic morphologic features and multinucleated + malignant cells may also be seen. + termDef: + term: >- + Sarcomatoid Mesothelioma + source: NCIt + cde_id: 'C45655 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45655 " + term_id: 'C45655 ' + term_version: 20.05a + +"90520": + common: + description: >- + A benign neoplasm arising from mesothelial cells. It is characterized by the + formation of glandular and tubular patterns. It can occur in several anatomic + sites including the pleura, peritoneum, and epididymis. + termDef: + term: >- + Adenomatoid Tumor + source: NCIt + cde_id: C3762 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3762" + term_id: C3762 + term_version: 20.05a + +"90523": + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of cells with epithelioid morphology. The epithelioid cells usually + have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, + or sheet-like patterns. + termDef: + term: >- + Epithelioid Mesothelioma + source: NCIt + cde_id: C7985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7985" + term_id: C7985 + term_version: 20.05a + +"90533": + common: + description: >- + A malignant mesothelioma characterized by the presence of epithelioid and sarcomatoid + components, with each component representing at least 10% of the tumor. + termDef: + term: >- + Biphasic Mesothelioma + source: NCIt + cde_id: C4282 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4282" + term_id: C4282 + term_version: 20.05a + +"90540": + common: + description: >- + A benign neoplasm arising from mesothelial cells. It is characterized by the + formation of glandular and tubular patterns. It can occur in several anatomic + sites including the pleura, peritoneum, and epididymis. + termDef: + term: >- + Adenomatoid Tumor + source: NCIt + cde_id: C3762 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3762" + term_id: C3762 + term_version: 20.05a + +"90551": + common: + description: >- + An intermediate grade neoplasm arising from mesothelial cells. It occurs in + the peritoneum, extraperitoneal space, omentum, or pelvic or abdominal viscera. + It is characterized by the presence of multiple cysts lined by flattened or + cuboidal mesothelial cells. There is no evidence of significant cytologic atypia + or increased mitotic activity. It usually occurs in young to middle-aged women. + Patients present with abdominal or pelvic mass and pain. Approximately half + of the cases recur. The recurrences may appear several years after the initial + diagnosis. Rare cases of transformation to malignant mesothelioma have also + been described. + termDef: + term: >- + Multicystic Mesothelioma + source: NCIt + cde_id: C3765 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3765" + term_id: C3765 + term_version: 20.05a + +"90603": + common: + description: >- + A malignant germ cell tumor characterized by the presence of a monotonous primitive + germ cell population. The neoplastic cells form aggregates and have an abundant + pale cytoplasm and uniform nuclei. The aggregates of the germ cells are separated + by fibrous septa which contain inflammatory cells, mostly T-lymphocytes. It + arises primarily in the ovaries, but can occur both primarily and secondarily + at other sites, particularly the central nervous system. It responds to chemotherapy + and radiotherapy. Its prognosis is related to the tumor stage. + termDef: + term: >- + Dysgerminoma + source: NCIt + cde_id: C2996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2996" + term_id: C2996 + term_version: 20.05a + +"90613": + common: + description: >- + A radiosensitive malignant germ cell tumor found in the testis (especially undescended), + and extragonadal sites (anterior mediastinum and pineal gland). It is characterized + by the presence of uniform cells with clear or dense cytoplasm which contains + glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic + germ cells form aggregates separated by fibrous septa. The fibrous septa contain + chronic inflammatory cells, mainly lymphocytes. + termDef: + term: >- + Seminoma + source: NCIt + cde_id: C9309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9309" + term_id: C9309 + term_version: 20.05a + +"90623": + common: + description: >- + A seminoma of the testis characterized by increased cellular pleomorphism, high + mitotic activity, and a non-prominent stromal lymphocytic infiltrate. + termDef: + term: >- + Testicular Seminoma with High Mitotic Index + source: NCIt + cde_id: C39920 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39920" + term_id: C39920 + term_version: 20.05a + +"90633": + common: + description: >- + A testicular germ cell tumor derived from postpubertal-type germ cells. It is + characterized by the presence of three cell types: round cells with eosinophilic + cytoplasm, small cells with dark nucleus and a small amount of cytoplasm, and + mono-or multinucleated giant cells. The neoplastic cells are not cohesive. There + is an edematous stroma present; lymphocytic infiltrates are rarely seen. Most + patients are older males. + termDef: + term: >- + Testicular Spermatocytic Tumor + source: NCIt + cde_id: C39921 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39921" + term_id: C39921 + term_version: 20.05a + +"90643": + common: + description: >- + A malignant germ cell tumor arising in the central nervous system. It is characterized + by the presence of primitive, large malignant germ cells and lymphocytes. + termDef: + term: >- + Germinoma + source: NCIt + cde_id: 'C3753 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3753 " + term_id: 'C3753 ' + term_version: 20.05a + +"90653": + common: + description: >- + A term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, + or mixed forms of these tumors. + termDef: + term: >- + Nongerminomatous Germ Cell Tumor + source: NCIt + cde_id: C121619 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121619" + term_id: C121619 + term_version: 20.05a + +"90703": + common: + description: >- + A non-seminomatous malignant germ cell tumor characterized by the presence of + large germ cells with abundant cytoplasm resembling epithelial cells, geographic + necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures + formation. It can arise from the testis, ovary, and extragonadal sites (central + nervous system and mediastinum). + termDef: + term: >- + Embryonal Carcinoma + source: NCIt + cde_id: C3752 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3752" + term_id: C3752 + term_version: 20.05a + +"90713": + common: + description: >- + A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It + is the most common malignant germ cell tumor in the pediatric population. It + occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, + abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor + mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment + includes: surgical resection, radiation, and chemotherapy. This tumor is very + responsive to chemotherapy regimens that include cisplatinum. + termDef: + term: >- + Yolk Sac Tumor + source: NCIt + cde_id: C3011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3011" + term_id: C3011 + term_version: 20.05a + +"90731": + common: + description: >- + A mixed germ cell/sex cord-stromal tumor characterized by the presence of large + germ cells which resemble seminoma cells and small cells which resemble Sertoli + or granulosa cells. It occurs in the testis and the ovary and is identified + in children and adults. It is often associated with gonadal dysgenesis and abnormal + karyotype. + termDef: + term: >- + Gonadoblastoma + source: NCIt + cde_id: C3754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3754" + term_id: C3754 + term_version: 20.05a + +"90800": + common: + description: >- + A teratoma which may be cystic; it is composed entirely of well differentiated, + adult-type mature tissues, without evidence of fetal-type immature tissues (grade + 0 teratoma). + termDef: + term: >- + Mature Teratoma + source: NCIt + cde_id: 'C9015 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9015 " + term_id: 'C9015 ' + term_version: 20.05a + +"90801": + common: + description: >- + A non-seminomatous germ cell tumor characterized by the presence of various + tissues which correspond to the different germinal layers (endoderm, mesoderm, + and ectoderm). It occurs in the testis, ovary, and extragonadal sites including + central nervous system, mediastinum, lung, and stomach. According to the level + of differentiation of the tissues which comprise the tumor, teratomas are classified + as benign (grade 0 or 1), immature (grade 2), and malignant (grade 3). Grade + 0 teratomas contain only mature elements; grade 1 teratomas have a limited degree + of immaturity; grade 2 teratomas have a more extensive degree of immaturity; + grade 3 teratomas are composed exclusively of immature tissues. The prognosis + depends on patient age, tumor size and grade, and stage. + termDef: + term: >- + Teratoma + source: NCIt + cde_id: C3403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3403" + term_id: C3403 + term_version: 20.05a + +"90803": + common: + description: >- + A teratoma characterized by the presence of an extensive component of immature, + fetal-type tissues. + termDef: + term: >- + Immature Teratoma + source: NCIt + cde_id: C4286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4286" + term_id: C4286 + term_version: 20.05a + +"90813": + common: + description: >- + A germ cell tumor characterized by the presence of an embryonal carcinoma component + and a teratoma component. + termDef: + term: >- + Mixed Embryonal Carcinoma and Teratoma + source: NCIt + cde_id: C3756 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3756" + term_id: C3756 + term_version: 20.05a + +"90823": + common: + description: >- + A teratoma composed exclusively of immature tissues. + termDef: + term: >- + Malignant Teratoma + source: NCIt + cde_id: C4287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4287" + term_id: C4287 + term_version: 20.05a + +"90833": + common: + description: >- + An immature teratoma characterized by the presence of an intermediate amount + of undifferentiated tissues. + termDef: + term: >- + Intermediate Immature Teratoma + source: NCIt + cde_id: C4288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4288" + term_id: C4288 + term_version: 20.05a + +"90840": + common: + description: >- + A mature teratoma characterized by the presence of a cyst which is lined by + mature tissue resembling the epidermis and the epidermal appendages. It occurs + in the ovary, testis, and extragonadal sites including central nervous system + and skin. + termDef: + term: >- + Dermoid Cyst + source: NCIt + cde_id: C9011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9011" + term_id: C9011 + term_version: 20.05a + +"90843": + common: + description: >- + A teratoma which is characterized by morphologic transformation to malignancy + and an aggressive clinical course. The malignant component most often is sarcomatous + or carcinomatous. + termDef: + term: >- + Teratoma with Somatic-Type Malignancy + source: NCIt + cde_id: C4289 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4289" + term_id: C4289 + term_version: 20.05a + +"90853": + common: + description: >- + A malignant germ cell tumor characterized by the presence of at least two different + germ cell tumor components. The different germ cell tumor components include + choriocarcinoma, embryonal carcinoma, yolk sac tumor, teratoma, and seminoma. + It occurs in the ovary, testis, and extragonadal sites including central nervous + system and mediastinum. + termDef: + term: >- + Mixed Germ Cell Tumor + source: NCIt + cde_id: 'C4290 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4290 " + term_id: 'C4290 ' + term_version: 20.05a + +"90863": + common: + description: >- + An extragonadal non-seminomatous malignant germ cell tumor that arises from + the mediastinum and is associated with a hematologic malignancy. The hematologic + malignancies are clonally related to the malignant germ cell tumor and include + acute leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, and + mastocytosis. + termDef: + term: >- + Malignant Mediastinal Germ Cell Tumor with Associated Hematologic Malignancy + source: NCIt + cde_id: C45733 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45733" + term_id: C45733 + term_version: 20.05a + +"90900": + common: + description: >- + An ovarian mature teratoma characterized by the presence of aberrant thyroid + tissue. The aberrant thyroid tissue shows morphologic changes identical to thyroid + adenoma or carcinoma. Patients may present with abdominal mass and unusual symptoms + due to thyrotoxicosis, or Meigs syndrome (ascites and pleural effusion). + termDef: + term: >- + Struma Ovarii + source: NCIt + cde_id: C7468 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7468" + term_id: C7468 + term_version: 20.05a + +"90903": + common: + description: >- + An ovarian mature teratoma characterized by the presence of aberrant thyroid + tissue with morphologic changes identical to thyroid carcinoma. Patients may + present with abdominal mass and unusual symptoms due to thyrotoxicosis, or with + Meigs syndrome (ascites and pleural effusion). + termDef: + term: >- + Malignant Struma Ovarii + source: NCIt + cde_id: C4291 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4291" + term_id: C4291 + term_version: 20.05a + +"90911": + common: + description: >- + An ovarian neoplasm characterized by the presence of aberrant thyroid tissue + and a carcinoid tumor. A minority of patients develop symptoms of functioning + thyroid tissue. The neuroendocrine carcinoid cells infiltrate the aberrant thyroid + tissue and progressively replace the follicular lining cells. + termDef: + term: >- + Strumal Carcinoid + source: NCIt + cde_id: C4292 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4292" + term_id: C4292 + term_version: 20.05a + +"91000": + common: + description: >- + A gestational trophoblastic disorder characterized by marked enlargement of + the chorionic villi, hyperplasia of the villous trophoblastic cells and hydropic + changes. + termDef: + term: >- + Hydatidiform Mole + source: NCIt + cde_id: 'C3110 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3110 " + term_id: 'C3110 ' + term_version: 20.05a + +"91001": + common: + description: >- + A complete hydatidiform mole or very rarely a partial mole that invades the + myometrium. + termDef: + term: >- + Invasive Hydatidiform Mole + source: NCIt + cde_id: C6985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6985" + term_id: C6985 + term_version: 20.05a + +"91003": + common: + description: >- + An aggressive malignant tumor arising from trophoblastic cells. The vast majority + of cases arise in the uterus and represent gestational choriocarcinomas that + derive from placental trophoblastic cells. Approximately half of the cases develop + from a complete hydatidiform mole. A minority of cases arise in the testis or + the ovaries. There is often marked elevation of human chorionic gonadotropin + (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous + route; the lungs are most frequently affected. + termDef: + term: >- + Choriocarcinoma + source: NCIt + cde_id: C2948 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2948" + term_id: C2948 + term_version: 20.05a + +"91013": + common: + description: >- + A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous + component admixed with another germ cell component (e.g. embryonal carcinoma, + teratoma, or seminoma). + termDef: + term: >- + Choriocarcinoma Combined with Other Germ Cell Elements + source: NCIt + cde_id: C66777 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66777" + term_id: C66777 + term_version: 20.05a + +"91023": + common: + description: >- + A malignant germ cell tumor which metastasizes widely and produces high levels + of human chorionic gonadotropin. + termDef: + term: >- + Malignant Trophoblastic Teratoma + source: NCIt + cde_id: C66778 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66778" + term_id: C66778 + term_version: 20.05a + +"91030": + common: + description: >- + A gestational trophoblastic disorder characterized by the presence of an abnormal + fetus and two populations of chorionic villi: one population which is unremarkable + and a second one which shows hydropic changes. + termDef: + term: >- + Partial Hydatidiform Mole + source: NCIt + cde_id: C4293 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4293" + term_id: C4293 + term_version: 20.05a + +"91041": + common: + description: >- + A rare gestational trophoblastic tumor characterized by the presence of a diffuse + cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts + and by the absense of a significant population of syncytiotrophoblasts. + termDef: + term: >- + Placental-Site Gestational Trophoblastic Tumor + source: NCIt + cde_id: C3757 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3757" + term_id: C3757 + term_version: 20.05a + +"91053": + common: + description: >- + A gestational trophoblastic tumor characterized by the presence of a monomorphous + cellular population of intermediate trophoblastic cells infiltrating in a nodular + pattern. + termDef: + term: >- + Epithelioid Trophoblastic Tumor + source: NCIt + cde_id: C6900 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6900" + term_id: C6900 + term_version: 20.05a + +"91100": + common: + description: >- + A benign epithelial neoplasm of the female reproductive system arising from + mesonephric remnants. + termDef: + term: >- + Benign Mesonephroma + source: NCIt + cde_id: C4294 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4294" + term_id: C4294 + term_version: 20.05a + +"91101": + common: + description: >- + An epithelial neoplasm of the female reproductive system arising from mesonephric + remnants. + termDef: + term: >- + Mesonephric Neoplasm + source: NCIt + cde_id: C4295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4295" + term_id: C4295 + term_version: 20.05a + +"91103": + common: + description: >- + An adenocarcinoma of the cervix or the vagina arising from mesonephric remnants. + termDef: + term: >- + Mesonephric Adenocarcinoma + source: NCIt + cde_id: 'C4072 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4072 " + term_id: 'C4072 ' + term_version: 20.05a + +"91200": + common: + description: >- + A benign vascular lesion characterized by the formation of capillary-sized or + cavernous vascular channels. + termDef: + term: >- + Hemangioma + source: NCIt + cde_id: C3085 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3085" + term_id: C3085 + term_version: 20.05a + +"91203": + common: + description: >- + A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, + it is characterized by frequently open vascular anastomosing and branching channels. The + malignant cells that line the vascular channels are spindle or epithelioid and + often display hyperchromatic nuclei. Angiosarcomas most frequently occur in + the skin and breast. Patients with long-standing lymphedema are at increased + risk of developing angiosarcoma. + termDef: + term: >- + Angiosarcoma + source: NCIt + cde_id: C3088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3088" + term_id: C3088 + term_version: 20.05a + +"91210": + common: + description: >- + A hemangioma characterized by the presence of cavernous vascular spaces. + termDef: + term: >- + Cavernous Hemangioma + source: NCIt + cde_id: C3086 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3086" + term_id: C3086 + term_version: 20.05a + +"91220": + common: + description: >- + A hemangioma composed of veins. + termDef: + term: >- + Venous Hemangioma + source: NCIt + cde_id: C4296 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4296" + term_id: C4296 + term_version: 20.05a + +"91250": + common: + description: >- + A hemangioma characterized by the presence of epithelioid endothelial cells. + termDef: + term: >- + Epithelioid Hemangioma + source: NCIt + cde_id: C4298 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4298" + term_id: C4298 + term_version: 20.05a + +"91300": + common: + description: >- + A benign vascular proliferation characterized by the presence of prominent endothelial + cells and the formation of vascular channels. + termDef: + term: >- + Benign Hemangioendothelioma + source: NCIt + cde_id: C66779 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66779" + term_id: C66779 + term_version: 20.05a + +"91301": + common: + description: >- + A vascular proliferation characterized by the presence of prominent endothelial + cells and the formation of vascular channels. Hemangioendotheliomas may display + borderline or low grade characteristics. + termDef: + term: >- + Hemangioendothelioma + source: NCIt + cde_id: 'C3084 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3084 " + term_id: 'C3084 ' + term_version: 20.05a + +"91303": + common: + description: >- + A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, + it is characterized by frequently open vascular anastomosing and branching channels. The + malignant cells that line the vascular channels are spindle or epithelioid and + often display hyperchromatic nuclei. Angiosarcomas most frequently occur in + the skin and breast. Patients with long-standing lymphedema are at increased + risk of developing angiosarcoma. + termDef: + term: >- + Angiosarcoma + source: NCIt + cde_id: C3088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3088" + term_id: C3088 + term_version: 20.05a + +"91310": + common: + description: >- + A common hemangioma characterized by the presence of capillary-sized vascular + channels without prominent epithelioid endothelial cells. + termDef: + term: >- + Capillary Hemangioma + source: NCIt + cde_id: 'C7457 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7457 " + term_id: 'C7457 ' + term_version: 20.05a + +"91320": + common: + description: >- + A hemangioma arising from skeletal muscle. + termDef: + term: >- + Intramuscular Hemangioma + source: NCIt + cde_id: C3699 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3699" + term_id: C3699 + term_version: 20.05a + +"91331": + common: + description: >- + A low-grade malignant blood vessel neoplasm. It is characterized by the presence + of epithelioid endothelial cells. The neoplastic cells are arranged in cords + and nests, which are embedded in a myxoid to hyalinized stroma. + termDef: + term: >- + Epithelioid Hemangioendothelioma + source: NCIt + cde_id: C3800 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3800" + term_id: C3800 + term_version: 20.05a + +"91351": + common: + description: >- + An intermediate, rarely metastasizing blood vessel neoplasm. It is characterized + by the presence of lymphatic-like vascular channels and papillary endothelial + proliferation. + termDef: + term: >- + Papillary Intralymphatic Angioendothelioma + source: NCIt + cde_id: C7526 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7526" + term_id: C7526 + term_version: 20.05a + +"91361": + common: + description: >- + A hemangioma characterized by the presence of spindle endothelial cells. + termDef: + term: >- + Spindle Cell Hemangioma + source: NCIt + cde_id: C4754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4754" + term_id: C4754 + term_version: 20.05a + +"91373": + common: + description: >- + A malignant neoplasm arising from the large blood vessels. It is characterized + by the presence of tumor cells that grow within the lumen of the blood vessels. The + intraluminal tumor growth may result in vascular obstruction and spread of tumor + emboli to peripheral organs. The prognosis is usually poor. + termDef: + term: >- + Intimal Sarcoma + source: NCIt + cde_id: C53677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53677" + term_id: C53677 + term_version: 20.05a + +"91403": + common: + description: >- + A malignant neoplasm characterized by a vascular proliferation which usually + contains blunt endothelial cells. Erythrocyte extravasation and hemosiderin + deposition are frequently present. The most frequent site of involvement is + the skin; however it may also occur internally. It generally develops in people + with compromised immune systems including those with acquired immune deficiency + syndrome (AIDS). + termDef: + term: >- + Kaposi Sarcoma + source: NCIt + cde_id: C9087 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9087" + term_id: C9087 + term_version: 20.05a + +"91410": + common: + description: >- + A vascular lesion in the papillary dermis resulting from ectasia of pre-existing + vessels. It is associated with secondary proliferative changes in the overlying + epidermis (hyperkeratosis). It can present with widespread lesions (angiokeratoma + corporis diffusum, often associated with inborn errors of metabolism) or as + a localized lesion (angiokeratoma of Fordyce, angiokeratoma circumscriptum, + and angiokeratoma of Mibelli). + termDef: + term: >- + Angiokeratoma + source: NCIt + cde_id: C2874 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2874" + term_id: C2874 + term_version: 20.05a + +"91420": + common: + description: >- + A skin hemangioma characterized by the presence of epidermal hyperplasia. + termDef: + term: >- + Verrucous Hemangioma + source: NCIt + cde_id: C4299 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4299" + term_id: C4299 + term_version: 20.05a + +"91500": + common: + description: >- + A hemangiopericytoma without malignant morphologic or clinical characteristics. + termDef: + term: >- + Benign Hemangiopericytoma + source: NCIt + cde_id: C4300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4300" + term_id: C4300 + term_version: 20.05a + +"91501": + common: + description: >- + An antiquated term that refers to benign or malignant mesenchymal neoplasms + characterized by the presence of neoplastic spindle-shaped to round cells arranged + around thin-walled branching vascular spaces. + termDef: + term: >- + Hemangiopericytoma + source: NCIt + cde_id: C3087 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3087" + term_id: C3087 + term_version: 20.05a + +"91503": + common: + description: >- + An uncommon malignant neoplasm arising from pericytes. Distinction between + benign and malignant hemangiopericytoma may be difficult or even impossible + on morphologic grounds alone. + termDef: + term: >- + Malignant Hemangiopericytoma + source: NCIt + cde_id: C4301 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4301" + term_id: C4301 + term_version: 20.05a + +"91600": + common: + description: >- + A morphologic variant of fibroma characterized by the presence of numerous dilated + vascular channels. + termDef: + term: >- + Angiofibroma + source: NCIt + cde_id: 'C3799 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3799 " + term_id: 'C3799 ' + term_version: 20.05a + +"91611": + common: + description: >- + A WHO grade I tumor of uncertain histogenesis which is composed of stromal cells + and abundant capillaries. Approximately 25% of hemangioblastomas are associated + with Von Hippel-Lindau disease, a disease inherited through an autosomal dominant + trait and characterized by the development of hemangioblastomas of the central + nervous system and retina, clear cell renal carcinoma, pheochromocytoma, and + pancreatic and inner ear tumors. (Adapted from WHO) + termDef: + term: >- + Hemangioblastoma + source: NCIt + cde_id: C3801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3801" + term_id: C3801 + term_version: 20.05a + +"91700": + common: + description: >- + A benign lesion composed of dilated lymphatic channels. Painless swelling is + the usual clinical manifestation. + termDef: + term: >- + Lymphangioma + source: NCIt + cde_id: 'C8965 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8965 " + term_id: 'C8965 ' + term_version: 20.05a + +"91703": + common: + description: >- + A malignant neoplasm arising from the endothelial cells of the lymphatic vessels. + termDef: + term: >- + Lymphangiosarcoma + source: NCIt + cde_id: C3205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3205" + term_id: C3205 + term_version: 20.05a + +"91720": + common: + description: >- + A lymphangioma characterized by the presence of thin-walled cavernous lymphatic + spaces. + termDef: + term: >- + Cavernous Lymphangioma + source: NCIt + cde_id: C53316 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53316" + term_id: C53316 + term_version: 20.05a + +"91730": + common: + description: >- + A benign lymphatic neoplasm usually arising from the neck and characterized + by cystic dilation of the lymphatic vessels. + termDef: + term: >- + Cystic Hygroma + source: NCIt + cde_id: C3724 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3724" + term_id: C3724 + term_version: 20.05a + +"91740": + common: + description: >- + A neoplasm with perivascular epithelioid cell differentiation, often associated + with tuberous sclerosis. It is characterized by the presence of smooth muscle + and epithelioid cells and by the proliferation of lymphatic vessels. Sites of + involvement include the lymph nodes, lung, mediastinum, and retroperitoneum. + termDef: + term: >- + Lymphangioleiomyoma + source: NCIt + cde_id: C3204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3204" + term_id: C3204 + term_version: 20.05a + +"91741": + common: + description: >- + A multifocal neoplasm with perivascular epithelioid cell differentiation affecting + almost exclusively females of child-bearing age. It is characterized by the + presence of smooth muscle and epithelioid cells and by the proliferation of + lymphatic vessels. Sites of involvement include the lungs, mediastinum, and + the retroperitoneum. It usually presents with chylous pleural effusion or ascites. + termDef: + term: >- + Lymphangioleiomyomatosis + source: NCIt + cde_id: C3725 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3725" + term_id: C3725 + term_version: 20.05a + +"91750": + common: + description: >- + A hemorrhagic lymphatic lesion characterized by the presence of dilated lymphatic + spaces, extravasation of red blood cells, hemosiderin deposition, and fibrosis. + termDef: + term: >- + Hemolymphangioma + source: NCIt + cde_id: C66792 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66792" + term_id: C66792 + term_version: 20.05a + +"91800": + common: + description: >- + A benign, well-circumscribed, bone-forming neoplasm predominantly composed of + lamellar bone. It usually arises from the calvarial, facial, or jaw bones. It + is usually asymptomatic but it may cause local swelling or obstruction of the + paranasal sinuses. Asymptomatic cases have an indolent clinical course. + termDef: + term: >- + Osteoma + source: NCIt + cde_id: C3296 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3296" + term_id: C3296 + term_version: 20.05a + +"91803": + common: + description: >- + A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly + affecting adolescents and young adults. It usually involves bones and less frequently + extraosseous sites. It often involves the long bones (particularly distal femur, + proximal tibia, and proximal humerus). Pain with or without a palpable mass + is the most frequent clinical symptom. It may spread to other anatomic sites, + particularly the lungs. + termDef: + term: >- + Osteosarcoma + source: NCIt + cde_id: 'C9145 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9145 " + term_id: 'C9145 ' + term_version: 20.05a + +"91813": + common: + description: >- + An osteosarcoma characterised by the presence of atypical cartilage of variable + cellularity. It may or may not be associated with the presence of myxoid areas + or focal bone formation. + termDef: + term: >- + Chondroblastic Osteosarcoma + source: NCIt + cde_id: C4021 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4021" + term_id: C4021 + term_version: 20.05a + +"91823": + common: + description: >- + A conventional osteosarcoma characterized by the presence of spindle shaped + cells. + termDef: + term: >- + Fibroblastic Osteosarcoma + source: NCIt + cde_id: C4020 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4020" + term_id: C4020 + term_version: 20.05a + +"91833": + common: + description: >- + An osteosarcoma usually arising from the metaphysis of long bones. It is characterized + by the presence of a cystic architecture with blood-filled spaces. The prognosis + is similar to that of conventional osteosarcoma. + termDef: + term: >- + Telangiectatic Osteosarcoma + source: NCIt + cde_id: C3902 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3902" + term_id: C3902 + term_version: 20.05a + +"91853": + common: + description: >- + An osteosarcoma usually arising from the metaphysis of long bones. It is characterized + by the presence of small cells and osteoid production. The prognosis is usually + unfavorable. + termDef: + term: >- + Small Cell Osteosarcoma + source: NCIt + cde_id: C4023 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4023" + term_id: C4023 + term_version: 20.05a + +"91863": + common: + description: >- + A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. + The tumor arises from the medullary portion of the bone. It affects the long + bones and most commonly, the distal femur, proximal tibia, and proximal humerus. + Pain with or without a palpable mass is the most common clinical presentation. + It usually has an aggressive growth and may metastasize through the hematogenous + route. The lung is the most frequent site of metastasis. + termDef: + term: >- + Conventional Osteosarcoma + source: NCIt + cde_id: C35870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35870" + term_id: C35870 + term_version: 20.05a + +"91873": + common: + description: >- + A low grade osteosarcoma arising from the medullary portion of the bone. It + affects the long bones and is characterized by the presence of fibroblastic + stroma and osteoid production. Pain and swelling are the usual sign and symptom. + The prognosis is more favorable than conventional osteosarcoma. + termDef: + term: >- + Low Grade Central Osteosarcoma + source: NCIt + cde_id: C6474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6474" + term_id: C6474 + term_version: 20.05a + +"91910": + common: + description: >- + A small, benign, bone-forming neoplasm that can arise from any bone but more + frequently affects the long bones. The central portion of the neoplasm (nidus) + contains differentiated osteoblasts which produce osteoid and sometimes bone. + The lesion is usually surrounded by hypervascular sclerotic bone and has limited + growth potential. Clinical signs and symptoms include pain and localized tenderness, + at the site of the lesion. The pain may be intense but in the majority of cases + it is completely alleviated by non-steroidal anti-inflammatory drugs. Prognosis + is excellent and recurrences are rare. + termDef: + term: >- + Osteoid Osteoma + source: NCIt + cde_id: C3297 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3297" + term_id: C3297 + term_version: 20.05a + +"91923": + common: + description: >- + A low grade malignant bone-forming mesenchymal neoplasm arising from the surface + of the bone. It usually affects the distal posterior femur, the proximal tibia, + and proximal humerus. Painless swelling is the usual clinical sign. Most patients + are young adults and the prognosis is usually excellent. + termDef: + term: >- + Parosteal Osteosarcoma + source: NCIt + cde_id: C8969 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8969" + term_id: C8969 + term_version: 20.05a + +"91933": + common: + description: >- + An intermediate grade malignant bone-forming mesenchymal neoplasm with chondroblastic + differentiation. It arises from the surface of the bone and affects the diaphysis + or diaphyseal- metaphyseal portion of the long bones. A painless mass or swelling + is the most common clinical sign. It is associated with a better prognosis + than conventional osteosarcoma. + termDef: + term: >- + Periosteal Osteosarcoma + source: NCIt + cde_id: C8970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8970" + term_id: C8970 + term_version: 20.05a + +"91943": + common: + description: >- + A usually aggressive high grade malignant bone-forming mesenchymal neoplasm + arising from the surface of the bone. + termDef: + term: >- + High Grade Surface Osteosarcoma + source: NCIt + cde_id: C53958 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53958" + term_id: C53958 + term_version: 20.05a + +"91953": + common: + description: >- + A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. + The tumor arises from the medullary portion of the bone. It affects the long + bones and most commonly, the distal femur, proximal tibia, and proximal humerus. + Pain with or without a palpable mass is the most common clinical presentation. + It usually has an aggressive growth and may metastasize through the hematogenous + route. The lung is the most frequent site of metastasis. + termDef: + term: >- + Conventional Osteosarcoma + source: NCIt + cde_id: C35870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35870" + term_id: C35870 + term_version: 20.05a + +"92000": + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the spine. It is a + well-circumscribed lytic tumor that varies in size. The tumor is composed of + woven bone trabeculae and shares similar histologic characteristics with the + osteoid osteoma. Surgical curettage is the treatment of choice. The prognosis + is excellent. + termDef: + term: >- + Osteoblastoma + source: NCIt + cde_id: C3294 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3294" + term_id: C3294 + term_version: 20.05a + +"92001": + common: + description: >- + An osteoblastoma characterized by the presence of prominent epithelioid osteoblasts + and recurrences. + termDef: + term: >- + Aggressive Osteoblastoma + source: NCIt + cde_id: C66796 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66796" + term_id: C66796 + term_version: 20.05a + +"92100": + common: + description: >- + A common, benign cartiliginous neoplasm arising from the metaphysis of bone. + The tumor grows on the surface of the bone; it may be pedunculated or sessile. + It is characterized by the presence of chondrocytes, a cartilage cap, and a + fibrous perichondrium that extends to the periosteum of the bone. In some cases, + there is deletion of 8q24.1 chromosome locus. + termDef: + term: >- + Osteochondroma + source: NCIt + cde_id: C3295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3295" + term_id: C3295 + term_version: 20.05a + +"92101": + common: + description: >- + An autosomal dominant neoplastic chondrogenic process affecting multiple sites. + It is caused by mutations in the EXT1 or EXT2 genes. Grossly and microscopically, + the lesions resemble an osteochondroma. + termDef: + term: >- + Multiple Osteochondromas + source: NCIt + cde_id: C53457 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53457" + term_id: C53457 + term_version: 20.05a + +"92200": + common: + description: >- + A benign well circumscribed neoplasm of hyaline cartilage arising from bone + or soft tissue. It is characterized by the presence of chondrocytes. + termDef: + term: >- + Chondroma + source: NCIt + cde_id: 'C53459 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53459 " + term_id: 'C53459 ' + term_version: 20.05a + +"92201": + common: + description: >- + A multifocal benign neoplasm arising from bone or soft tissue. It is characterized + by the presence of chondrocytes and is composed of hyaline cartilage. + termDef: + term: >- + Chondromatosis + source: NCIt + cde_id: C35259 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35259" + term_id: C35259 + term_version: 20.05a + +"92203": + common: + description: >- + A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from + the bone and soft tissue. It usually affects middle-aged to elderly adults. The + pelvic bones, ribs, shoulder girdle, and long bones are the most common sites + of involvement. Most chondrosarcomas arise de novo, but some may develop in + a preexisting benign cartilaginous lesion. + termDef: + term: >- + Chondrosarcoma + source: NCIt + cde_id: C2946 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2946" + term_id: C2946 + term_version: 20.05a + +"92210": + common: + description: >- + A benign neoplasm of bone surface composed of hyaline cartilage. It arises + beneath the periosteum and is characterized by the presence of chondrocytes, + a lobulated growth pattern, and calcification. + termDef: + term: >- + Periosteal Chondroma + source: NCIt + cde_id: C4302 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4302" + term_id: C4302 + term_version: 20.05a + +"92213": + common: + description: >- + A chondrosarcoma arising from the surface of bone. It is characterized by a + lobulated growth pattern, high mitotic activity, myxoid stroma formation, and + necrotic changes. It occurs in adults. Clinical presentation includes pain, + and sometimes swelling. + termDef: + term: >- + Periosteal Chondrosarcoma + source: NCIt + cde_id: C7357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7357" + term_id: C7357 + term_version: 20.05a + +"92300": + common: + description: >- + A benign, chondroid-producing, well-circumscribed, lytic neoplasm usually arising + from the epiphysis of long bones. It is characterized by the presence of chondroblasts, + osteoclast-like giant cells, chondroid formation, calcification, and mitotic + activity. In aggressive cases, there is rearrangement of the 8q21 chromosome + band. It occurs most frequently in children and young adults and rarely metastasizes. + termDef: + term: >- + Chondroblastoma + source: NCIt + cde_id: C2945 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2945" + term_id: C2945 + term_version: 20.05a + +"92313": + common: + description: >- + A chondrosarcoma characterized by the presence of myxoid changes. + termDef: + term: >- + Myxoid Chondrosarcoma + source: NCIt + cde_id: C4303 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4303" + term_id: C4303 + term_version: 20.05a + +"92403": + common: + description: >- + A morphologic variant of chondrosarcoma arising from bone and soft tissue. It + is characterized by the presence of malignant small round cells, biphasic growth + pattern, and well differentiated hyaline cartilage. Clinical presentation includes + pain and swelling. The clinical course is aggressive, with local recurrences + and distant metastases. + termDef: + term: >- + Mesenchymal Chondrosarcoma + source: NCIt + cde_id: C3737 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3737" + term_id: C3737 + term_version: 20.05a + +"92410": + common: + description: >- + An uncommon benign cartilaginous neoplasm arising from the bone. It is characterized + by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth + pattern, myxoid stroma formation, and sometimes multinucleated giant cells. + It has been associated with chromosomal rearrangement of 6q13 and 6q25 bands. + The most common clinical symptom is mild, localized pain. + termDef: + term: >- + Chondromyxoid Fibroma + source: NCIt + cde_id: C3830 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3830" + term_id: C3830 + term_version: 20.05a + +"92423": + common: + description: >- + A rare, usually low grade chondrosarcoma characterized by the presence of tumor + cells with clear cytoplasm. It usually arises in the epiphyseal ends of long + bones. + termDef: + term: >- + Clear Cell Chondrosarcoma + source: NCIt + cde_id: C6475 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6475" + term_id: C6475 + term_version: 20.05a + +"92433": + common: + description: >- + An aggressive morphologic variant of chondrosarcoma. It is composed of a low + grade chondrosarcoma and a high grade non-cartilagenous sarcomatous component. + Due to the aggressive nature of the disease, its prognosis is poor. + termDef: + term: >- + Dedifferentiated Chondrosarcoma + source: NCIt + cde_id: C6476 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6476" + term_id: C6476 + term_version: 20.05a + +"92501": + common: + description: >- + A benign but locally aggressive tumor that arises from the bone and is composed + of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It + usually arises from the ends of long bones or the vertebrae. Clinical presentation + includes pain, edema, and decreased range of motion in the affected joint. + termDef: + term: >- + Giant Cell Tumor of Bone + source: NCIt + cde_id: C121932 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121932" + term_id: C121932 + term_version: 20.05a + +"92503": + common: + description: >- + A malignant tumor that arises from the bone. It is characterized by the presence + of an area of high grade sarcoma in an otherwise typical giant cell tumor (primary + malignancy in giant cell tumor), or the presence of sarcoma in which the pre-existing + giant cell tumor may or may not be apparent (secondary malignancy in giant cell + tumor). + termDef: + term: >- + Malignancy in Giant Cell Tumor of Bone + source: NCIt + cde_id: 'C4304 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4304 " + term_id: 'C4304 ' + term_version: 20.05a + +"92511": + common: + description: >- + A painless, well circumscribed tumor arising in soft tissue, usually of the + upper and lower extremities. Morphologically, it is characterized by a multinodular + growth pattern. The cellular infiltrate is composed of mononuclear round or + oval cells and multinucleated osteoclast-like giant cells, in a rich vascular + stroma. It rarely metastasizes. + termDef: + term: >- + Giant Cell Tumor of Soft Tissue + source: NCIt + cde_id: C49107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49107" + term_id: C49107 + term_version: 20.05a + +"92513": + common: + description: >- + An undifferentiated pleomorphic sarcoma characterized by the presence of osteoclast-like + giant cells and cellular pleomorphism. + termDef: + term: >- + Undifferentiated Pleomorphic Sarcoma with Osteoclast-Like Giant Cells + source: NCIt + cde_id: C8380 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8380" + term_id: C8380 + term_version: 20.05a + +"92520": + common: + description: >- + A tumor usually arising in the synovium of joints, bursa or tendon sheath. It + is characterized by the presence of mononuclear cells, multinucleated osteoclast-like + giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory + infiltrate. According to the growth pattern, it is classified as localized or + diffuse. + termDef: + term: >- + Tenosynovial Giant Cell Tumor + source: NCIt + cde_id: C3402 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3402" + term_id: C3402 + term_version: 20.05a + +"92523": + common: + description: >- + An uncommon malignant tumor arising from the tendon sheath. Morphologically, + it is characterized by the presence of a cellular infiltrate reminiscent of + a giant cell tumor with prominent malignant characteristics. Recurrent giant + cell tumors with a sarcomatous dedifferentiation are included in this category + as well. + termDef: + term: >- + Malignant Tenosynovial Giant Cell Tumor + source: NCIt + cde_id: C6535 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6535" + term_id: C6535 + term_version: 20.05a + +"92603": + common: + description: >- + A small round cell tumor that lacks morphologic, immunohistochemical, and electron + microscopic evidence of neuroectodermal differentiation. It represents one of + the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal + tumor. It affects mostly males under age 20, and it can occur in soft tissue + or bone. Pain and the presence of a mass are the most common clinical symptoms. + termDef: + term: >- + Ewing Sarcoma + source: NCIt + cde_id: C4817 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4817" + term_id: C4817 + term_version: 20.05a + +"92613": + common: + description: >- + A low grade malignant neoplasm arising from the long bones. The tibia is the + most frequently affected bone site. Patients present with swelling which may + or may not be associated with pain. Morphologically, it is characterized by + a biphasic pattern consisting of an epithelial and an osteofibrous component. + The vast majority of cases recur if they are not treated with radical surgery. + In a minority of cases the tumor may metastasize to other anatomic sites including + lymph nodes, lungs, liver, brain, and skeleton. + termDef: + term: >- + Adamantinoma + source: NCIt + cde_id: 'C7644 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7644 " + term_id: 'C7644 ' + term_version: 20.05a + +"92620": + common: + description: >- + A well circumscribed lesion of the bone, most frequently arising from the posterior + mandible. It is characterized by the presence of fibrous tissue and a mineralized + component which may be woven bone, lamellar bone, or cementum-like material. + Complete removal is recommended, since it continues to enlarge if left untreated. + termDef: + term: >- + Ossifying Fibroma + source: NCIt + cde_id: C8422 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8422" + term_id: C8422 + term_version: 20.05a + +"92700": + common: + description: >- + A benign, slow growing neoplasm arising from tooth-forming tissues. It occurs + in the maxillofacial skeleton or the gingiva. Representative examples include + adenomatoid odontogenic tumor, calcifying cystic odontogenic tumor, and squamous + odontogenic tumor. + termDef: + term: >- + Benign Odontogenic Neoplasm + source: NCIt + cde_id: C4306 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4306" + term_id: C4306 + term_version: 20.05a + +"92701": + common: + description: >- + A benign or malignant neoplasm arising from tooth-forming tissues. It occurs + in the maxillofacial skeleton or the gingiva. Benign tumors are slow growing + and are not associated with specific clinical symptoms. Pain is absent or slight. + Malignant tumors are usually associated with rapid swelling and pain. + termDef: + term: >- + Odontogenic Neoplasm + source: NCIt + cde_id: C3286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3286" + term_id: C3286 + term_version: 20.05a + +"92703": + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial + skeleton or the gingiva. Symptoms include swelling, pain, bleeding, mobility + of affected teeth, and oral mucosa ulcerations. It may metastasize to lymph + nodes and distant anatomic sites early. + termDef: + term: >- + Malignant Odontogenic Neoplasm + source: NCIt + cde_id: 'C4812 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4812 " + term_id: 'C4812 ' + term_version: 20.05a + +"92710": + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It usually arises from the + posterior mandible. It is characterized by the presence of an epithelial component, + fibromyxoid stroma, and dentin formation. It is treated with enucleation and + curettage. Recurrences may occur. + termDef: + term: >- + Ameloblastic Fibrodentinoma + source: NCIt + cde_id: 'C66800 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66800 " + term_id: 'C66800 ' + term_version: 20.05a + +"92720": + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the jaw. It is a well-circumscribed + lytic tumor that varies in size. The cell of origin is the cementoblast. + termDef: + term: >- + Cementoblastoma + source: NCIt + cde_id: C4308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4308" + term_id: C4308 + term_version: 20.05a + +"92730": + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the jaw. It is a well-circumscribed + lytic tumor that varies in size. The cell of origin is the cementoblast. + termDef: + term: >- + Cementoblastoma + source: NCIt + cde_id: C4308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4308" + term_id: C4308 + term_version: 20.05a + +"92740": + common: + description: >- + A well circumscribed lesion of the bone, most frequently arising from the posterior + mandible. It is characterized by the presence of fibrous tissue and a mineralized + component which may be woven bone, lamellar bone, or cementum-like material. + Complete removal is recommended, since it continues to enlarge if left untreated. + termDef: + term: >- + Ossifying Fibroma + source: NCIt + cde_id: C8422 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8422" + term_id: C8422 + term_version: 20.05a + +"92750": + common: + description: >- + A rare, benign, slow growing, multifocal, and expansile lesion of the jaws. + Both familiar and sporadic cases have been reported. It is characterized by + a fibroblastic proliferation, cementum, and limited bone formation. + termDef: + term: >- + Gigantiform Cementoma + source: NCIt + cde_id: C8381 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8381" + term_id: C8381 + term_version: 20.05a + +"92800": + common: + description: >- + A benign, slow growing, and painless hamartomatous tumor occurring in tooth-bearing + areas of the jaws. According to the presence or absence of tooth-like structures, + it is classified as complex type or compound type. Odontoma of complex type + is characterized by the presence of enamel and dentin and the absence of tooth-like + structures. It is treated with local excision. If it is incompletely removed, + it may recur. Odontoma of compound type is characterized by the presence of + tooth-like structures. It is treated by local excision. Recurrences have not + been reported. + termDef: + term: >- + Odontoma + source: NCIt + cde_id: C3287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3287" + term_id: C3287 + term_version: 20.05a + +"92810": + common: + description: >- + A benign, slow growing, and painless hamartomatous tumor occurring in tooth-bearing + areas of the jaws. It usually affects children and adolescents. It is characterized + by the presence of tooth-like structures. Treatment consists of local excision. + Recurrences have not been reported. + termDef: + term: >- + Compound Odontoma + source: NCIt + cde_id: C3711 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3711" + term_id: C3711 + term_version: 20.05a + +"92820": + common: + description: >- + A benign, slow growing, and painless hamartomatous tumor occurring in tooth-bearing + areas of the jaws. It is one of the most common odontogenic tumors and it usually + affects children, adolescents, and young adults. It is characterized by the + presence of enamel and dentin and the absence of tooth-like structures. It is + treated with local excision. If it is incompletely removed, it may recur. + termDef: + term: >- + Complex Odontoma + source: NCIt + cde_id: C4309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4309" + term_id: C4309 + term_version: 20.05a + +"92900": + common: + description: >- + A rare benign neoplasm arising from tooth-forming tissues. It is characterized + by the presence of a fibromyxoid stroma, epithelial component, dentin, and enamel. + Recurrences are rare. + termDef: + term: >- + Ameloblastic Fibro-Odontoma + source: NCIt + cde_id: C3710 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3710" + term_id: C3710 + term_version: 20.05a + +"93000": + common: + description: >- + A benign, slow growing neoplasm arising from tooth-forming tissues. The vast + majority of cases are intraosseous and most often grow in the maxilla. It is + characterized by the presence of odontogenic epithelium which is embedded in + a connective tissue stroma. Local excision is curative and recurrences are very + rare. + termDef: + term: >- + Adenomatoid Odontogenic Tumor + source: NCIt + cde_id: C4310 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4310" + term_id: C4310 + term_version: 20.05a + +"93010": + common: + description: >- + A benign, intraosseous or extraosseous cystic neoplasm arising from tooth-forming + tissues. It is characterized by the presence of a cyst lined by an ameloblastoma-like + epithelium and ghost cells formation. The ghost cells may undergo calcification. + It is treated with enucleation. Few recurrences have been reported for intraosseous + neoplasms whereas no recurrences have been reported for extraosseous neoplasms. + termDef: + term: >- + Calcifying Cystic Odontogenic Tumor + source: NCIt + cde_id: C54319 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54319" + term_id: C54319 + term_version: 20.05a + +"93020": + common: + description: >- + A carcinoma usually arising from the maxilla and less often the mandible. Symptoms + include swelling and paresthesia. It is characterized by the presence of rounded + islands of malignant epithelial cells in a fibrous stroma and the benign features + of calcifying cystic odontogenic tumor. The clinical course varies from slow + growing and locally invasive to rapidly growing and highly aggressive with metastases. + termDef: + term: >- + Ghost Cell Odontogenic Carcinoma + source: NCIt + cde_id: C4311 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4311" + term_id: C4311 + term_version: 20.05a + +"93023": + common: + description: >- + A carcinoma usually arising from the maxilla and less often the mandible. Symptoms + include swelling and paresthesia. It is characterized by the presence of rounded + islands of malignant epithelial cells in a fibrous stroma and the benign features + of calcifying cystic odontogenic tumor. The clinical course varies from slow + growing and locally invasive to rapidly growing and highly aggressive with metastases. + termDef: + term: >- + Ghost Cell Odontogenic Carcinoma + source: NCIt + cde_id: C4311 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4311" + term_id: C4311 + term_version: 20.05a + +"93100": + common: + description: >- + The most common odontogenic tumor, arising from the epithelial component of + the embryonic tooth and usually affecting the molar-ramus region of the mandible + or maxilla. Although most ameloblastomas are morphologically and clinically + benign, they may cause extensive local destruction, recur, or metastasize. + termDef: + term: >- + Ameloblastoma + source: NCIt + cde_id: C4313 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4313" + term_id: C4313 + term_version: 20.05a + +"93103": + common: + description: >- + A rare, well differentiated, cytologically benign ameloblastoma which paradoxically + metastasizes. + termDef: + term: >- + Metastasizing Ameloblastoma + source: NCIt + cde_id: C54297 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54297" + term_id: C54297 + term_version: 20.05a + +"93110": + common: + description: >- + A rare, locally aggressive neoplasm arising from tooth-forming tissues. It occurs + in the mandible and maxilla. It is characterized by the presence of odontogenic + epithelium and adjacent myxoid tissue, fibrous stroma, and mineralized dental + tissues. + termDef: + term: >- + Odontoameloblastoma + source: NCIt + cde_id: C54317 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54317" + term_id: C54317 + term_version: 20.05a + +"93120": + common: + description: >- + A rare, locally invasive neoplasm arising from tooth-forming tissues. It usually + grows intraosseously in the mandible. The maxilla is less frequently involved. + It is characterized by the presence of well differentiated squamous cells which + form islands. Recurrences may rarely occur and probably are related to incomplete + excision of the tumor. + termDef: + term: >- + Squamous Odontogenic Tumor + source: NCIt + cde_id: C7112 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7112" + term_id: C7112 + term_version: 20.05a + +"93200": + common: + description: >- + An intraosseous odontogenic neoplasm with good prognosis, arising from the mandible + and less frequently from the maxilla. It is characterized by the presence of + stellate cells and abundant myxoid stroma formation. Small tumors may be cured + with enucleation. Complete excision may be required for larger tumors. + termDef: + term: >- + Odontogenic Myxoma + source: NCIt + cde_id: 'C7501 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7501 " + term_id: 'C7501 ' + term_version: 20.05a + +"93210": + common: + description: >- + A rare, benign, intraosseous neoplasm arising from tooth-forming tissues in + the mandible and maxilla. It is characterized by the presence of odontogenic + epithelium which is embedded in a fibrous stroma. Local enucleation of the tumor + is curative. + termDef: + term: >- + Odontogenic Fibroma + source: NCIt + cde_id: C4314 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4314" + term_id: C4314 + term_version: 20.05a + +"93220": + common: + description: >- + A rare, benign, extraosseous neoplasm arising from tooth-forming tissues. It + usually presents as a slow growing exophytic mass in the gingiva. It is characterized + by the presence of odontogenic epithelium which is embedded in a fibrous stroma. + termDef: + term: >- + Peripheral Odontogenic Fibroma + source: NCIt + cde_id: C4315 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4315" + term_id: C4315 + term_version: 20.05a + +"93300": + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It usually arises from the + posterior mandible. It is characterized by the presence of an epithelial component + and fibromyxoid stroma. It may recur and rarely shows malignant transformation + to ameloblastic fibrosarcoma. It is treated with enucleation and curettage. + termDef: + term: >- + Ameloblastic Fibroma + source: NCIt + cde_id: C4316 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4316" + term_id: C4316 + term_version: 20.05a + +"93303": + common: + description: >- + A locally aggressive malignant neoplasm arising from odontogenic tissue. It + occurs in the mandible and less often in the maxilla. It is characterized by + the presence of a malignant connective tissue component and a benign epithelial + component. The frequency of distal metastases is low. + termDef: + term: >- + Ameloblastic Fibrosarcoma + source: NCIt + cde_id: C4317 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4317" + term_id: C4317 + term_version: 20.05a + +"93400": + common: + description: >- + A slow growing, locally invasive neoplasm arising from tooth-forming tissues. + It most often grows intraosseously in the mandible and less frequently in the + maxilla. In a minority of cases it grows extraosseously in the gingiva. It is + characterized by the presence of a fibrous stroma, epithelial cells with abundant + eosinophilic cytoplasm, and amyloid material which is often calcified. Small + tumors may be successfully treated with enucleation. Local resection is usually + required for larger tumors. Recurrences have been reported in a minority of + cases. + termDef: + term: >- + Calcifying Epithelial Odontogenic Tumor + source: NCIt + cde_id: C54301 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54301" + term_id: C54301 + term_version: 20.05a + +"93411": + common: + description: >- + A usually aggressive malignant neoplasm arising from tooth-forming tissues. + It more often affects older females and more frequently occurs in the mandible. + It is characterized by the presence of malignant epithelial cells with clear + cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases + may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection + with clean margins. + termDef: + term: >- + Clear Cell Odontogenic Carcinoma + source: NCIt + cde_id: C54300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54300" + term_id: C54300 + term_version: 20.05a + +"93413": + common: + description: >- + A usually aggressive malignant neoplasm arising from tooth-forming tissues. + It more often affects older females and more frequently occurs in the mandible. + It is characterized by the presence of malignant epithelial cells with clear + cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases + may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection + with clean margins. + termDef: + term: >- + Clear Cell Odontogenic Carcinoma + source: NCIt + cde_id: C54300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54300" + term_id: C54300 + term_version: 20.05a + +"93423": + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial + skeleton or the gingiva. Symptoms include swelling, pain, bleeding, mobility + of affected teeth, and oral mucosa ulcerations. It may metastasize to lymph + nodes and distant anatomic sites early. + termDef: + term: >- + Malignant Odontogenic Neoplasm + source: NCIt + cde_id: C4812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4812" + term_id: C4812 + term_version: 20.05a + +"93501": + common: + description: >- + A benign, partly cystic, epithelial tumor of the sellar region, presumably derived + from Rathke pouch epithelium. It affects mainly children and young adults. There + are two clinicopathological forms: adamantinomatous craniopharyngioma and papillary + craniopharyngioma. The most significant factor associated with recurrence is + the extent of surgical resection, with lesions greater than 5 cm in diameter + carrying a markedly worse prognosis. (Adapted from WHO) + termDef: + term: >- + Craniopharyngioma + source: NCIt + cde_id: C2964 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2964" + term_id: C2964 + term_version: 20.05a + +"93511": + common: + description: >- + A craniopharyngioma consisting of broad strands, cords and bridges of a multistratified + squamous epithelium with peripheral palisading of nuclei. Diagnostic features + include nodules of compact 'wet' keratin and dystrophic calcification. (Adapted + from WHO) + termDef: + term: >- + Adamantinomatous Craniopharyngioma + source: NCIt + cde_id: C4726 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4726" + term_id: C4726 + term_version: 20.05a + +"93521": + common: + description: >- + A craniopharyngioma composed of sheets of squamous epithelium which separate + to form pseudopapillae. This variant typically lacks nuclear palisading, wet + keratin, calcification, and cholesterol deposits. Clinically, endocrine deficiencies + are more often associated with papillary craniopharyngioma than with the adamantinomatous + type. (Adapted from WHO) + termDef: + term: >- + Papillary Craniopharyngioma + source: NCIt + cde_id: C4725 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4725" + term_id: C4725 + term_version: 20.05a + +"93601": + common: + description: >- + A neoplasm arising from the pineocyte, a cell with photosensory and neuroendocrine + functions. It may be composed of mature elements or primitive, immature cells. + The cellular composition determines the biological behavior and clinical outcome. + Three types are recognized: pineoblastoma, pineocytoma, and pineal parenchymal + tumor of intermediate differentiation (Adapted from WHO.) + termDef: + term: >- + Pineal Parenchymal Cell Neoplasm + source: NCIt + cde_id: C6965 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6965" + term_id: C6965 + term_version: 20.05a + +"93611": + common: + description: >- + A WHO grade I slow growing tumor, more frequently affecting young adults. It + is composed of small, uniform, mature cells resembling pineocytes with occasional + large pineocytomatous rosettes. It may show a wide range of divergent phenotypes, + including neuronal, glial, melanocytic, photoreceptor and mesenchymal differentiation. + Pineocytoma generally has a relatively favorable prognosis. (Adapted from WHO) + termDef: + term: >- + Pineocytoma + source: NCIt + cde_id: C6966 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6966" + term_id: C6966 + term_version: 20.05a + +"93623": + common: + description: >- + A poorly differentiated malignant embryonal neoplasm arising from the pineal + region. It usually occurs in children and it is characterized by the presence + of small immature neuroepithelial cells. It may follow an aggressive clinical + course. + termDef: + term: >- + Pineoblastoma + source: NCIt + cde_id: 'C9344 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9344 " + term_id: 'C9344 ' + term_version: 20.05a + +"93630": + common: + description: >- + A rare neoplasm usually occurring in infants. It is characterized by the presence + of a mixture of melanin-containing epithelial cells and smaller neuroblast-like + cells. It may involve the skull and facial bones, or the epididymis. It usually + has a benign clinical course. + termDef: + term: >- + Melanotic Neuroectodermal Tumor + source: NCIt + cde_id: C3717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3717" + term_id: C3717 + term_version: 20.05a + +"93643": + common: + description: >- + A small round cell tumor with neural differentiation arising from the soft tissues + or bone. + termDef: + term: >- + Peripheral Primitive Neuroectodermal Tumor + source: NCIt + cde_id: 'C9341 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9341 " + term_id: 'C9341 ' + term_version: 20.05a + +"93653": + common: + description: >- + A primitive neuroectodermal tumor (small round blue cell tumor) of the thorax + which can involve the periosteum, thoracic wall and/or pleura though it spares + the lung parenchyma. + termDef: + term: >- + Askin Tumor + source: NCIt + cde_id: C7542 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7542" + term_id: C7542 + term_version: 20.05a + +"93703": + common: + description: >- + A malignant bone tumor arising from the remnants of the fetal notochord. Although + it can occur at all ages, it is more frequently seen in middle-aged adults. + The most frequent sites of involvement are the sacrococcygeal area, spheno-occipital + area, and cervico-thoraco-lumbar spine. Microscopically, chordomas are composed + of cells that form cords and lobules, separated by mucoid intercellular tissue. + Some of the cells are large (physaliphorous) and have vacuolated cytoplasm and + prominent vesicular nuclei. Other tumor cells are small with small nuclei without + visible nucleoli. Chordomas tend to recur and may metastasize. The most common + sites of metastasis are the skin and bone. + termDef: + term: >- + Chordoma + source: NCIt + cde_id: C2947 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2947" + term_id: C2947 + term_version: 20.05a + +"93713": + common: + description: >- + A slow-growing malignant bone tumor arising from the remnants of the notochord + and occurring in the base of the skull. The tumor is characterized by a lobulated + growth pattern, myxoid stroma formation, and the presence of physaliphorous + cells and cartilage. + termDef: + term: >- + Chondroid Chordoma + source: NCIt + cde_id: C6902 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6902" + term_id: C6902 + term_version: 20.05a + +"93723": + common: + description: >- + A high-grade malignant bone tumor arising from the remnants of the notochord. + It is characterized by a lobulated growth pattern, myxoid stroma formation, + the presence of physaliphorous cells, and a sarcomatous component. + termDef: + term: >- + Dedifferentiated Chordoma + source: NCIt + cde_id: C48876 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48876" + term_id: C48876 + term_version: 20.05a + +"93730": + common: + description: >- + A rare, usually benign myoepithelial tumor characterized by the presence of + epithelioid, often vacuolated neoplastic cells. Most patients present with painless + swelling in the subcutaneous or subfascial soft tissues of the extremities. + termDef: + term: >- + Parachordoma + source: NCIt + cde_id: C6581 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6581" + term_id: C6581 + term_version: 20.05a + +"93803": + common: + description: >- + A grade III or grade IV glioma arising from the central nervous system. This + category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, + anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. + termDef: + term: >- + Malignant Glioma + source: NCIt + cde_id: 'C4822 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4822 " + term_id: 'C4822 ' + term_version: 20.05a + +"93813": + common: + description: >- + A diffuse glial tumor which infiltrates the brain extensively, involving more + than two lobes. It is frequently bilateral and often extends to the infratentorial + structures, even to the spinal cord. It is probably of astrocytic origin, although + GFAP expression may be scant or absent. (Adapted from WHO.) + termDef: + term: >- + Gliomatosis Cerebri + source: NCIt + cde_id: C4318 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4318" + term_id: C4318 + term_version: 20.05a + +"93823": + common: + description: >- + A tumor composed of two or more glial cell types (astrocytes, ependymal cells, + and oligodendrocytes). + termDef: + term: >- + Mixed Glioma + source: NCIt + cde_id: 'C3903 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3903 " + term_id: 'C3903 ' + term_version: 20.05a + +"93831": + common: + description: >- + A benign, slow growing neoplasm which is typically attached to a ventricular + wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary + matrix with frequent microcystic change. Some lesions have the histological + features of both subependymoma and ependymoma. It is often detected incidentally + and has a very favorable prognosis. (Adapted from WHO.) + termDef: + term: >- + Subependymoma + source: NCIt + cde_id: C3795 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3795" + term_id: C3795 + term_version: 20.05a + +"93841": + common: + description: >- + A benign, slowly growing tumor (WHO grade I) typically arising in the wall of + the lateral ventricles and composed of large ganglioid astrocytes. It is the + most common CNS neoplasm in patients with tuberous sclerosis complex and typically + occurs during the first two decades of life. (WHO) + termDef: + term: >- + Subependymal Giant Cell Astrocytoma + source: NCIt + cde_id: C3696 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3696" + term_id: C3696 + term_version: 20.05a + +"93853": + common: + description: >- + A childhood diffuse midline glioma characterized by the presence of histone + H3 K27M mutation. + termDef: + term: >- + Diffuse Midline Glioma, H3 K27M-Mutant + source: NCIt + cde_id: C129309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129309" + term_id: C129309 + term_version: 20.05a + +"93900": + common: + description: >- + A benign, slow growing tumor which may cause symptoms by blocking cerebrospinal + fluid pathways. It is characterized by the presence of delicate fibrovascular + connective tissue fronds covered by a single layer of epithelial cells. Mitotic + activity is extremely low. Surgical resection is usually curative. (Adapted + from WHO) + termDef: + term: >- + Choroid Plexus Papilloma + source: NCIt + cde_id: C3698 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3698" + term_id: C3698 + term_version: 20.05a + +"93901": + common: + description: >- + A choroid plexus papilloma characterized by increased mitotic activity. + termDef: + term: >- + Atypical Choroid Plexus Papilloma + source: NCIt + cde_id: C53686 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53686" + term_id: C53686 + term_version: 20.05a + +"93903": + common: + description: >- + A malignant neoplasm arising from the choroid plexus. It shows anaplastic features + and usually invades neighboring brain structures. Cerebrospinal fluid metastases + are frequent. (Adapted from WHO) + termDef: + term: >- + Choroid Plexus Carcinoma + source: NCIt + cde_id: C4715 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4715" + term_id: C4715 + term_version: 20.05a + +"93913": + common: + description: >- + A WHO grade II, slow growing tumor of children and young adults, usually located + intraventricularly. It is the most common ependymal neoplasm. It often causes + clinical symptoms by blocking cerebrospinal fluid pathways. Key histological + features include perivascular pseudorosettes and ependymal rosettes. (WHO) + termDef: + term: >- + Ependymoma + source: NCIt + cde_id: 'C3017 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3017 " + term_id: 'C3017 ' + term_version: 20.05a + +"93923": + common: + description: >- + A WHO grade III malignant glioma of ependymal origin with accelerated growth + and an unfavorable clinical outcome, particularly in children. It is characterized + by high mitotic activity, often accompanied by microvascular proliferation and + pseudo-palisading necrosis. (Adapted from WHO) + termDef: + term: >- + Anaplastic Ependymoma + source: NCIt + cde_id: 'C4049 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4049 " + term_id: 'C4049 ' + term_version: 20.05a + +"93933": + common: + description: >- + A rare variant of ependymoma characterized by well formed papillae. Tumor cell + processes abutting capillaries are usually GFAP-positive. Differential diagnoses + include choroid plexus papilloma, papillary meningioma and metastatic papillary + carcinoma. (Adapted from WHO) + termDef: + term: >- + Papillary Ependymoma + source: NCIt + cde_id: C4319 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4319" + term_id: C4319 + term_version: 20.05a + +"93941": + common: + description: >- + A slow growing, WHO grade I glioma which generally occurs in young adults. It + arises almost exclusively in the conus medullaris, cauda equina, and filum terminale + of the spinal cord. It generally has a favorable prognosis and is characterized + histologically by tumor cells arranged in a papillary manner around vascularized + mucoid stromal cores. (Adapted from WHO). + termDef: + term: >- + Myxopapillary Ependymoma + source: NCIt + cde_id: C3697 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3697" + term_id: C3697 + term_version: 20.05a + +"93953": + common: + description: >- + A rare tumor that arises from the pineal region and affects adults. It is characterized + by the presence of neuroepithelial cells and a papillary architecture. Electron + microscopic studies suggest ependymal differentiation. The clinical course + is variable. + termDef: + term: >- + Papillary Tumor of the Pineal Region + source: NCIt + cde_id: C92624 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92624" + term_id: C92624 + term_version: 20.05a + +"93963": + common: + description: >- + An ependymoma characterized by gene fusions involving RELA, a transcription + factor involved in NK-kB pathway activity. It accounts for the majority of supratentorial + ependymomas in children. It has an unfavorable outcome when compared to other + ependymoma subtypes. + termDef: + term: >- + Ependymoma, RELA Fusion-Positive + source: NCIt + cde_id: C129351 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129351" + term_id: C129351 + term_version: 20.05a + +"94003": + common: + description: >- + A tumor of the brain or spinal cord showing astrocytic differentiation. It includes + the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, + anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant + cell astrocytoma. + termDef: + term: >- + Astrocytoma + source: NCIt + cde_id: 'C60781 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C60781 " + term_id: 'C60781 ' + term_version: 20.05a + +"94013": + common: + description: >- + A diffusely infiltrating, WHO grade III astrocytoma with focal or dispersed + anaplasia, and a marked proliferative potential. It may arise from a low-grade + astrocytoma, but it can also be diagnosed at first biopsy, without indication + of a less malignant precursor lesion. It has an intrinsic tendency for malignant + progression to glioblastoma. (WHO) + termDef: + term: >- + Anaplastic Astrocytoma + source: NCIt + cde_id: C9477 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9477" + term_id: C9477 + term_version: 20.05a + +"94103": + common: + description: >- + A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic + astrocytes showing a small cell body with few, flaccid processes with a low + content of glial filaments and scant GFAP expression. This lesion is not well + defined and is considered by some authors as an occasional histopathological + feature rather than a reproducibly identifiable variant. When occurring in children, + this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. + (Adapted from WHO) + termDef: + term: >- + Protoplasmic Astrocytoma + source: NCIt + cde_id: C4320 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4320" + term_id: C4320 + term_version: 20.05a + +"94113": + common: + description: >- + A rare variant of diffuse astrocytoma. It is characterized by the presence of + a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. + Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary + cytoplasm which appears to displace the dark, angulated nucleus to the periphery + of the cell. To make the diagnosis of gemistocytic astrocytoma, gemistocytes + should amount to more than approximately 20% of all tumor cells. (Adapted from + WHO) + termDef: + term: >- + Gemistocytic Astrocytoma + source: NCIt + cde_id: C4321 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4321" + term_id: C4321 + term_version: 20.05a + +"94121": + common: + description: >- + A WHO grade I large cystic tumor that occurs almost exclusively in infants, + with a prominent desmoplastic stroma having a neuroepithelial population consisting + mainly of neoplastic astrocytes. It involves the superficial cerebral cortex + and leptomeninges, and often attaches to the dura. Although clinically it presents + as large tumor, it generally has a good prognosis following surgical resection. + (Adapted from WHO) + termDef: + term: >- + Desmoplastic Infantile Astrocytoma + source: NCIt + cde_id: 'C9476 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9476 " + term_id: 'C9476 ' + term_version: 20.05a + +"94130": + common: + description: >- + A benign glial-neuronal neoplasm. It is usually supratentorial, located in the + cortex. It occurs in children and young adults with a long-standing history + of partial seizures. A histologic hallmark of this tumor is the 'specific glioneuronal + element', characterized by columns, made up of bundles of axons, oriented perpendicularly + to the cortical surface. (Adapted from WHO) + termDef: + term: >- + Dysembryoplastic Neuroepithelial Tumor + source: NCIt + cde_id: C9505 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9505" + term_id: C9505 + term_version: 20.05a + +"94203": + common: + description: >- + The most frequent histological variant of diffuse astrocytoma. It is predominantly + composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic + criterion but mitotic activity, necrosis and microvascular proliferation are + absent. The occasional or regional occurrence of gemistocytic neoplastic cells + is compatible with the diagnosis of fibrillary astrocytoma. (WHO) + termDef: + term: >- + Fibrillary Astrocytoma + source: NCIt + cde_id: C4322 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4322" + term_id: C4322 + term_version: 20.05a + +"94211": + common: + description: >- + A WHO grade I, relatively circumscribed, slowly growing, often cystic astrocytoma + occurring in children and young adults. Histologically it is characterized + by a biphasic pattern with compacted bipolar cells associated with Rosenthal + fibers and multipolar cells associated with microcysts and eosinophilic bodies/hyaline + droplets. (WHO) + termDef: + term: >- + Pilocytic Astrocytoma + source: NCIt + cde_id: 'C4047 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4047 " + term_id: 'C4047 ' + term_version: 20.05a + +"94233": + common: + description: >- + A lesion characterized by the presence of neoplastic neuroepithelial cells with + palisading nuclei. This lesion implies a morphologic growth pattern and it is + not considered a clinicopathological entity. + termDef: + term: >- + Polar Spongioblastoma + source: NCIt + cde_id: C66801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66801" + term_id: C66801 + term_version: 20.05a + +"94243": + common: + description: >- + A WHO grade ll astrocytic tumor with a relatively favorable prognosis. It is + characterized by pleomorphic and lipidized cells expressing GFAP often surrounded + by a reticulin network and eosinophilic granular bodies. It presents in the + superficial cerebral hemispheres and involves the meninges. It typically affects + children and young adults. + termDef: + term: >- + Pleomorphic Xanthoastrocytoma + source: NCIt + cde_id: C4323 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4323" + term_id: C4323 + term_version: 20.05a + +"94253": + common: + description: >- + An astrocytic tumor of uncertain relation to pilocytic astrocytoma. It occurs + predominantly in infants and young children. It is characterized by a monomorphic + architectural pattern, usually associated with the absence of Rosenthal fibers + and eosinophilic granular bodies. The clinical course is usually aggressive. + termDef: + term: >- + Pilomyxoid Astrocytoma + source: NCIt + cde_id: C40315 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40315" + term_id: C40315 + term_version: 20.05a + +"94303": + common: + description: >- + A rare glial neoplasm more commonly found in young adults. It is characterized + by tumor cells with characteristics suggestive of an astrocytic origin (positive + for GFAP), arranged perivascularly. The cells have broad, non-tapering processes + radiating towards a central blood vessel. The biologic behavior of astroblastomas + is variable, so no WHO grade has been established, yet. (Adapted from WHO.) + termDef: + term: >- + Astroblastoma + source: NCIt + cde_id: C4324 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4324" + term_id: C4324 + term_version: 20.05a + +"94311": + common: + description: >- + A WHO grade I, slow-growing brain neoplasm of children and young adults, associated + with epilepsy. Morphologically it is characterized by an angiocentric pattern, + monomorphic cellular infiltrate, and ependymal differentiation. + termDef: + term: >- + Angiocentric Glioma + source: NCIt + cde_id: C92552 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92552" + term_id: C92552 + term_version: 20.05a + +"94321": + common: + description: >- + An extremely rare, WHO grade I, circumscribed and slow-growing tumor that arises + from the neurohypophysis or infundibulum and described in adults. It is characterized + by the presence of elongated, spindle-shaped neoplastic glial cells that form + storiform patterns or interlacing fascicular arrangements. Signs and symptoms + include visual disturbances, headache, amenorrhea, and decreased libido. + termDef: + term: >- + Pituicytoma + source: NCIt + cde_id: C94524 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94524" + term_id: C94524 + term_version: 20.05a + +"94403": + common: + description: >- + The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly + differentiated neoplastic astrocytes and it is characterized by the presence + of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, + microvascular proliferation and necrosis. It typically affects adults and is + preferentially located in the cerebral hemispheres. It may develop from diffuse + astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, + IDH-mutant), but more frequently, it manifests after a short clinical history + de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, + IDH- wildtype). (Adapted from WHO) + termDef: + term: >- + Glioblastoma + source: NCIt + cde_id: C3058 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3058" + term_id: C3058 + term_version: 20.05a + +"94413": + common: + description: >- + A rare histological variant of glioblastoma (WHO grade IV) with a predominance + of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin + network, and a high frequency of TP53 mutations. (WHO) + termDef: + term: >- + Giant Cell Glioblastoma + source: NCIt + cde_id: C4325 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4325" + term_id: C4325 + term_version: 20.05a + +"94421": + common: + description: >- + An astrocytic tumor affecting young people. Morphologically, it is characterized + by the presence of collagenous tissue surrounding neoplastic astrocytes. In + some cases the collagen is produced by the tumor cells (desmoplastic astrocytoma), + whereas in others it is produced by mesenchymal cells (mixed glioma/fibroma). + termDef: + term: >- + Gliofibroma + source: NCIt + cde_id: C5419 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5419" + term_id: C5419 + term_version: 20.05a + +"94423": + common: + description: >- + A rare histological variant of glioblastoma (WHO grade IV) characterized by + a biphasic tissue pattern with alternating areas displaying glial and mesenchymal + differentiation (WHO). + termDef: + term: >- + Gliosarcoma + source: NCIt + cde_id: C3796 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3796" + term_id: C3796 + term_version: 20.05a + +"94441": + common: + description: >- + A rare, slow-growing neuroepithelial neoplasm of uncertain origin affecting + adults. It is located in the third ventricle. It is characterized by the presence + of epithelioid cells which express GFAP, and mucinous stroma which contains + lymphoplasmacytic infiltrates. + termDef: + term: >- + Chordoid Glioma of the Third Ventricle + source: NCIt + cde_id: C5592 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5592" + term_id: C5592 + term_version: 20.05a + +"94453": + common: + description: >- + A glioblastoma associated with IDH1 or IDH2 gene mutations. + termDef: + term: >- + Glioblastoma, IDH-Mutant + source: NCIt + cde_id: C167335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167335" + term_id: C167335 + term_version: 20.05a + +"94503": + common: + description: >- + A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, + typically located in the cerebral hemispheres. It is composed predominantly + of cells which morphologically resemble oligodendroglia. The neoplastic cells + have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear + cytoplasm ('honeycomb' appearance). (Adapted from WHO) + termDef: + term: >- + Oligodendroglioma + source: NCIt + cde_id: C3288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3288" + term_id: C3288 + term_version: 20.05a + +"94513": + common: + description: >- + A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic + features (prominent nuclear pleomorphism, mitoses, and increased cellularity). + termDef: + term: >- + Anaplastic Oligodendroglioma + source: NCIt + cde_id: C4326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4326" + term_id: C4326 + term_version: 20.05a + +"94603": + common: + description: >- + An obsolete term referring to neoplasms arising from oligodendrocytes. + termDef: + term: >- + Oligodendroblastoma + source: NCIt + cde_id: C66802 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66802" + term_id: C66802 + term_version: 20.05a + +"94703": + common: + description: >- + A malignant, invasive embryonal neoplasm arising from the cerebellum or posterior + fossa. It occurs predominantly in children and has the tendency to metastasize + via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, + disturbed gait, lethargy, headache, and vomiting. There are four histologic + variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular + medulloblastoma, and medulloblastoma with extensive nodularity. + termDef: + term: >- + Medulloblastoma + source: NCIt + cde_id: 'C3222 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3222 " + term_id: 'C3222 ' + term_version: 20.05a + +"94713": + common: + description: >- + A medulloblastoma characterized by the presence of nodular, collagenous areas + which do not contain reticulin, surrounded by hypercellular areas which contain + an intercellular reticulin fiber network. + termDef: + term: >- + Desmoplastic/Nodular Medulloblastoma + source: NCIt + cde_id: 'C4956 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4956 " + term_id: 'C4956 ' + term_version: 20.05a + +"94723": + common: + description: >- + A rare malignant embryonal neoplasm arising from the cerebellum. It is characterized + by the morphologic features of a medulloblastoma and the presence of a striated + muscle component. Its clinical behavior is similar to medulloblastoma. + termDef: + term: >- + Medullomyoblastoma with Myogenic Differentiation + source: NCIt + cde_id: C3706 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3706" + term_id: C3706 + term_version: 20.05a + +"94733": + common: + description: >- + A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm + constitutes the portion of the ectoderm of the early embryo that gives rise + to the central and peripheral nervous systems and includes some glial cell precursors. + termDef: + term: >- + Primitive Neuroectodermal Tumor + source: NCIt + cde_id: 'C3716 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3716 " + term_id: 'C3716 ' + term_version: 20.05a + +"94743": + common: + description: >- + A medulloblastoma composed of large cells with prominent nucleoli and a larger + amount of cytoplasm in contrast with the cells of the classic medulloblastoma. + termDef: + term: >- + Large Cell Medulloblastoma + source: NCIt + cde_id: 'C6904 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6904 " + term_id: 'C6904 ' + term_version: 20.05a + +"94753": + common: + description: >- + A molecular subtype of medulloblastoma associated with activation of the WNT + pathway. TP53 mutations may be present or absent. WNT pathway activation in + medulloblastomas is associated with good outcome. + termDef: + term: >- + Medulloblastoma, WNT-Activated + source: NCIt + cde_id: C129440 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129440" + term_id: C129440 + term_version: 20.05a + +"94763": + common: + description: >- + Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog + (SHH) pathway. TP53 mutations are absent. This molecular subtype includes medulloblastomas + numerically designated as "group 3" and "group 4". + termDef: + term: >- + Medulloblastoma, Non-WNT/Non-SHH + source: NCIt + cde_id: C129444 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129444" + term_id: C129444 + term_version: 20.05a + +"94773": + common: + description: >- + Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog + (SHH) pathway. TP53 mutations are absent. This molecular subtype includes medulloblastomas + numerically designated as "group 3" and "group 4". + termDef: + term: >- + Medulloblastoma, Non-WNT/Non-SHH + source: NCIt + cde_id: C129444 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129444" + term_id: C129444 + term_version: 20.05a + +"94783": + common: + description: >- + A central nervous system embryonal neoplasm characterized by the presence of + histological features consistent with embryonal tumor with multilayered rosettes + and absence of C19MC amplification. + termDef: + term: >- + Embryonal Tumor with Multilayered Rosettes, Not Otherwise Specified + source: NCIt + cde_id: C129499 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129499" + term_id: C129499 + term_version: 20.05a + +"94803": + common: + description: >- + An obsolete term referring to desmoplastic medulloblastoma. + termDef: + term: >- + Cerebellar Sarcoma + source: NCIt + cde_id: C66803 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66803" + term_id: C66803 + term_version: 20.05a + +"94900": + common: + description: >- + A benign neuroblastic tumor of the sympathetic nervous system that occurs in + childhood. Ganglioneuroma typically arises from the sympathetic trunk in the + mediastinum. Histologic features include spindle cell proliferation (resembling + a neurofibroma) and the presence of large ganglion cells. Common presenting + features include a palpable abdominal mass, hepatomegaly, and a thoracic mass + detected on routine chest X-ray. + termDef: + term: >- + Ganglioneuroma + source: NCIt + cde_id: C3049 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3049" + term_id: C3049 + term_version: 20.05a + +"94903": + common: + description: >- + A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion + cells, and a stroma with Schwannian differentiation constituting more than fifty-percent + of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, + intermixed and ganglioneuroblastoma, nodular. + termDef: + term: >- + Ganglioneuroblastoma + source: NCIt + cde_id: C3790 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3790" + term_id: C3790 + term_version: 20.05a + +"94910": + common: + description: >- + Extensive and diffuse infiltration of tissues by ganglioneuroma. + termDef: + term: >- + Ganglioneuromatosis + source: NCIt + cde_id: C66804 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66804" + term_id: C66804 + term_version: 20.05a + +"94920": + common: + description: >- + A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, + mature ganglion cells. + termDef: + term: >- + Gangliocytoma + source: NCIt + cde_id: C6934 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6934" + term_id: C6934 + term_version: 20.05a + +"94930": + common: + description: >- + A benign, WHO grade I cerebellar mass, which occurs in young adults and is composed + of dysplastic ganglion cells. It is the major CNS manifestation of Cowden disease, + an autosomal dominant condition that causes a variety of hamartomas and neoplasms. + termDef: + term: >- + Dysplastic Cerebellar Gangliocytoma + source: NCIt + cde_id: C8419 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8419" + term_id: C8419 + term_version: 20.05a + +"95003": + common: + description: >- + A neuroblastic tumor characterized by the presence of neuroblastic cells, the + absence of ganglion cells, and the absence of a prominent Schwannian stroma + formation. + termDef: + term: >- + Neuroblastoma + source: NCIt + cde_id: C3270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3270" + term_id: C3270 + term_version: 20.05a + +"95013": + common: + description: >- + A rare, usually aggressive malignant embryonal neoplasm of the central nervous + system occurring in children. It is characterized by the presence of neuroepithelial + cells which form papillary, trabecular, or tubular structures and absence of + C19MC amplification. Symptoms include headache, nausea, and vomiting. + termDef: + term: >- + Medulloepithelioma + source: NCIt + cde_id: C4327 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4327" + term_id: C4327 + term_version: 20.05a + +"95033": + common: + description: >- + A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm + constitutes the portion of the ectoderm of the early embryo that gives rise + to the central and peripheral nervous systems and includes some glial cell precursors. + termDef: + term: >- + Primitive Neuroectodermal Tumor + source: NCIt + cde_id: C3716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3716" + term_id: C3716 + term_version: 20.05a + +"95043": + common: + description: >- + A neuroectodermal tumor composed of neoplastic neural elements. + termDef: + term: >- + Spongioneuroblastoma + source: NCIt + cde_id: C66811 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66811" + term_id: C66811 + term_version: 20.05a + +"95051": + common: + description: >- + A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, + mature ganglion cells and neoplastic glial cells. Some gangliogliomas show anaplastic + features in their glial component and are considered to be WHO grade III. Rare + cases of newly diagnosed gangliogliomas with grade IV (glioblastoma) changes + in the glial component have also been reported. (Adapted from WHO) + termDef: + term: >- + Ganglioglioma + source: NCIt + cde_id: C3788 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3788" + term_id: C3788 + term_version: 20.05a + +"95053": + common: + description: >- + A WHO grade III neuroepithelial neoplasm composed of neoplastic, mature ganglion + cells and anaplastic glial cells. The anaplastic changes in the glial component + and high MIB-1 and TP53 labeling indices may indicate aggressive behavior. However, + the correlation of histological anaplasia with clinical outcome is inconsistent. + (Adapted from WHO) + termDef: + term: >- + Anaplastic Ganglioglioma + source: NCIt + cde_id: C4717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4717" + term_id: C4717 + term_version: 20.05a + +"95061": + common: + description: >- + An intraventricular neuronal neoplasm composed of uniform round cells with neuronal + differentiation. It is typically located in the lateral ventricles in the region + of the foramen of Monro. It generally affects young adults and has a favorable + prognosis. (Adapted from WHO) + termDef: + term: >- + Central Neurocytoma + source: NCIt + cde_id: 'C3791 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3791 " + term_id: 'C3791 ' + term_version: 20.05a + +"95070": + common: + description: >- + A neurofibroma characterized by the presence of structures which resemble Vater-Pacini + corpuscles. + termDef: + term: >- + Pacinian Neurofibroma + source: NCIt + cde_id: C4328 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4328" + term_id: C4328 + term_version: 20.05a + +"95083": + common: + description: >- + An aggressive malignant embryonal neoplasm arising from the central nervous + system. It is composed of cells with a large eccentric nucleus, prominent nucleolus, + and abundant cytoplasm. Mutations of the INI1 gene or very rarely SMARCA4 (BRG1) + gene are present. The vast majority of cases occur in childhood. Symptoms include + lethargy, vomiting, cranial nerve palsy, headache, and hemiplegia. + termDef: + term: >- + Atypical Teratoid/Rhabdoid Tumor + source: NCIt + cde_id: C6906 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6906" + term_id: C6906 + term_version: 20.05a + +"95091": + common: + description: >- + A WHO grade I, indolent and relatively circumscribed brain tumor. Morphologically + it is characterized by the presence of astrocytes that line vascular and hyalinized + pseudopapillae. In between the pseudopapillae aggregates of neurocytes, large + neurons, and ganglioid cells are present. + termDef: + term: >- + Papillary Glioneuronal Tumor + source: NCIt + cde_id: 'C92554 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92554 " + term_id: 'C92554 ' + term_version: 20.05a + +"95100": + common: + description: >- + A rare, unilateral or bilateral benign retinal neoplasm. Since there is a risk + of malignant transformation to retinoblastoma, patients should be closely observed. + termDef: + term: >- + Retinocytoma + source: NCIt + cde_id: C66812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66812" + term_id: C66812 + term_version: 20.05a + +"95103": + common: + description: >- + A malignant tumor that originates in the nuclear layer of the retina. As the + most common primary tumor of the eye in children, retinoblastoma is still relatively + uncommon, accounting for only 1% of all malignant tumors in pediatric patients. + Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, + bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas + are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has + been associated with 13q14 cytogenetic abnormalities. Patients with the inherited + form also appear to be at increased risk for secondary nonocular malignancies + such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. + termDef: + term: >- + Retinoblastoma + source: NCIt + cde_id: C7541 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7541" + term_id: C7541 + term_version: 20.05a + +"95113": + common: + description: >- + A retinoblastoma with well differentiated features. It often produces Flexner-Wintersteiner + rosettes or Homer-Wright rosettes. In some cases the tumor cells form fleurettes. + termDef: + term: >- + Differentiated Retinoblastoma + source: NCIt + cde_id: C66813 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66813" + term_id: C66813 + term_version: 20.05a + +"95123": + common: + description: >- + A retinoblastoma composed of small, undifferentiated cells. It is often associated + with necrotic changes. + termDef: + term: >- + Undifferentiated Retinoblastoma + source: NCIt + cde_id: C66814 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66814" + term_id: C66814 + term_version: 20.05a + +"95133": + common: + description: >- + A retinoblastoma characterized by the absence of a distinct retinal mass and + the presence of malignant cells diffusely infiltrating the retina. It is often + confused with uveitis and endophthalmitis, resulting in delayed diagnosis of + the malignancy. + termDef: + term: >- + Diffuse Retinoblastoma + source: NCIt + cde_id: C66815 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66815" + term_id: C66815 + term_version: 20.05a + +"95141": + common: + description: >- + This term applies to a retinoblastoma which has regressed spontaneously. Histologic + examination of the tumor reveals benign-appearing tumor cells, with no evidence + of nuclear atypia, pleomorphism, or rosettes formation. There is a well-vascularized + stroma which contains calcifications. + termDef: + term: >- + Spontaneously Regressing Retinoblastoma + source: NCIt + cde_id: C66816 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66816" + term_id: C66816 + term_version: 20.05a + +"95203": + common: + description: >- + A rare, benign (olfactory neurocytoma) or malignant (olfactory neuroblastoma) + neuroectodermal tumor originating from olfactory receptor cells in the nasal + cavity. + termDef: + term: >- + Olfactory Neurogenic Tumor + source: NCIt + cde_id: C67155 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67155" + term_id: C67155 + term_version: 20.05a + +"95213": + common: + description: >- + A rare benign neuroectodermal tumor originating from olfactory receptor cells + in the nasal cavity. Microscopically, it is characterized by the absence of + malignant characteristics and the absence of rosettes formation. + termDef: + term: >- + Olfactory Neurocytoma + source: NCIt + cde_id: C67156 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67156" + term_id: C67156 + term_version: 20.05a + +"95223": + common: + description: >- + A rare neuroectodermal tumor originating from olfactory receptor cells in the + nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic + differentiation with occasional formation of rosettes. If the tumor is not resected + at an early stage, the prognosis is usually poor. + termDef: + term: >- + Olfactory Neuroblastoma + source: NCIt + cde_id: C3789 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3789" + term_id: C3789 + term_version: 20.05a + +"95233": + common: + description: >- + A rare neuroectodermal tumor originating from olfactory receptor cells in the + nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic + differentiation with occasional formation of rosettes. If the tumor is not resected + at an early stage, the prognosis is usually poor. + termDef: + term: >- + Olfactory Neuroblastoma + source: NCIt + cde_id: C3789 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3789" + term_id: C3789 + term_version: 20.05a + +"95300": + common: + description: >- + A generally slow growing tumor attached to the dura mater. It is composed of + neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, + often women and it has a wide range of histopathological appearances. Of the + various subtypes, meningothelial, fibrous and transitional meningiomas are the + most common. Most meningiomas are WHO grade I tumors, and some are WHO grade + II or III tumors. Most subtypes share a common clinical behavior, although some + subtypes are more likely to recur and follow a more aggressive clinical course. + (Adapted from WHO) + termDef: + term: >- + Meningioma + source: NCIt + cde_id: 'C3230 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3230 " + term_id: 'C3230 ' + term_version: 20.05a + +"95301": + common: + description: >- + The presence of multiple meningiomas in the leptomeninges. + termDef: + term: >- + Meningiomatosis + source: NCIt + cde_id: C3707 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3707" + term_id: C3707 + term_version: 20.05a + +"95303": + common: + description: >- + A WHO grade III meningioma characterized by the presence of malignant morphologic + features, including malignant cytology and a very high mitotic index (20 or + more mitoses per ten high power fields). + termDef: + term: >- + Anaplastic (Malignant) Meningioma + source: NCIt + cde_id: 'C4051 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4051 " + term_id: 'C4051 ' + term_version: 20.05a + +"95310": + common: + description: >- + A WHO grade I meningioma characterized by the presence of tumor cells that form + lobules. The tumor cells are generally uniform. Whorls and psammoma bodies are + usually not present. + termDef: + term: >- + Meningothelial Meningioma + source: NCIt + cde_id: C4329 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4329" + term_id: C4329 + term_version: 20.05a + +"95320": + common: + description: >- + A WHO grade I meningioma characterized by the presence of spindle cells that + form bundles in a collagen matrix. + termDef: + term: >- + Fibrous Meningioma + source: NCIt + cde_id: C4330 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4330" + term_id: C4330 + term_version: 20.05a + +"95330": + common: + description: >- + A WHO grade I meningioma characterized by the presence of psammoma bodies that + predominate over the meningeal cells. + termDef: + term: >- + Psammomatous Meningioma + source: NCIt + cde_id: C4331 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4331" + term_id: C4331 + term_version: 20.05a + +"95340": + common: + description: >- + A WHO grade I meningioma characterized by the presence of small and medium sized + vessels that predominate over the meningioma cells. + termDef: + term: >- + Angiomatous Meningioma + source: NCIt + cde_id: C4332 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4332" + term_id: C4332 + term_version: 20.05a + +"95350": + common: + description: >- + An obsolete term referring to hemangiopericytoma of the central nervous system. + termDef: + term: >- + Hemangioblastic Meningioma + source: NCIt + cde_id: C66817 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66817" + term_id: C66817 + term_version: 20.05a + +"95370": + common: + description: >- + A WHO grade I meningioma characterized by the coexistence of meningothelial + cells and fibrous architectural patterns. + termDef: + term: >- + Transitional Meningioma + source: NCIt + cde_id: C4333 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4333" + term_id: C4333 + term_version: 20.05a + +"95381": + common: + description: >- + A WHO grade II morphologic variant of meningioma characterized by the presence + of clear glycogen-rich polygonal cells. + termDef: + term: >- + Clear Cell Meningioma + source: NCIt + cde_id: 'C4722 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4722 " + term_id: 'C4722 ' + term_version: 20.05a + +"95383": + common: + description: >- + A WHO grade III meningioma characterized by the predominance of a perivascular + pseudopapillary pattern. + termDef: + term: >- + Papillary Meningioma + source: NCIt + cde_id: 'C3904 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3904 " + term_id: 'C3904 ' + term_version: 20.05a + +"95391": + common: + description: >- + A WHO grade II meningioma characterized by the presence of brain invasion and + an increased mitotic activity, or at least three of the following morphologic + features: small cells, high cellularity, prominent nucleoli, lack of architectural + pattern, and necrosis. + termDef: + term: >- + Atypical Meningioma + source: NCIt + cde_id: C4723 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4723" + term_id: C4723 + term_version: 20.05a + +"95393": + common: + description: >- + A rare condition characterized by diffuse spread of sarcoma cells throughout + the meninges. The neoplastic cells are derived from meningeal connective tissue. + Clinically, this disorder may present as a fulminant pachymeningitis and/or + encephalitis. + termDef: + term: >- + Meningeal Sarcomatosis + source: NCIt + cde_id: C4334 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4334" + term_id: C4334 + term_version: 20.05a + +"95400": + common: + description: >- + An intraneural or extraneural neoplasm arising from nerve tissues and neural + sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It + usually presents as a localized cutaneous lesion and less often as a circumscribed + peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple + masses. Neurofibromas which arise from major nerves and plexiform neurofibromas + are precursor lesions to malignant peripheral nerve sheath tumors. + termDef: + term: >- + Neurofibroma + source: NCIt + cde_id: C3272 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3272" + term_id: C3272 + term_version: 20.05a + +"95401": + common: + description: >- + An autosomal dominant hereditary neoplastic syndrome. Two distinct clinicopathological + entities are recognized: neurofibromatosis type 1 and neurofibromatosis type + 2. Neurofibromatosis type 1 is associated with the presence of cafe-au-lait + cutaneous lesions, multiple neurofibromas, malignant peripheral nerve sheath + tumors, optic nerve gliomas, and bone lesions. Neurofibromatosis type 2 is associated + with the presence of schwannomas, meningiomas, and gliomas. + termDef: + term: >- + Neurofibromatosis + source: NCIt + cde_id: 'C6727 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6727 " + term_id: 'C6727 ' + term_version: 20.05a + +"95403": + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: 'C3798 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798 " + term_id: 'C3798 ' + term_version: 20.05a + +"95410": + common: + description: >- + A rare neurofibroma characterized by the presence of melanin-laden cells and + the absence of atypia. + termDef: + term: >- + Melanotic Neurofibroma + source: NCIt + cde_id: C66841 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66841" + term_id: C66841 + term_version: 20.05a + +"95423": + common: + description: >- + A rare variant of malignant peripheral nerve sheath tumor composed predominantly + or exclusively of epithelioid cells. + termDef: + term: >- + Epithelioid Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C6561 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6561" + term_id: C6561 + term_version: 20.05a + +"95500": + common: + description: >- + An elongated and multinodular neurofibroma, formed when the tumor involves either + multiple trunks of a plexus or multiple fascicles of a large nerve, such as + the sciatic. Some plexiform neurofibromas resemble a bag of worms, others produce + a massive ropy enlargement of the nerve. (Adapted from WHO) + termDef: + term: >- + Plexiform Neurofibroma + source: NCIt + cde_id: C3797 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3797" + term_id: C3797 + term_version: 20.05a + +"95600": + common: + description: >- + A benign, usually encapsulated slow growing tumor composed of Schwann cells. It + affects peripheral and cranial nerves. It recurs infrequently and only rare + cases associated with malignant transformation have been reported. + termDef: + term: >- + Schwannoma + source: NCIt + cde_id: 'C3269 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3269 " + term_id: 'C3269 ' + term_version: 20.05a + +"95601": + common: + description: >- + A rare genetic disorder characterized by the presence of multiple schwannomas. + termDef: + term: >- + Schwannomatosis + source: NCIt + cde_id: C6557 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6557" + term_id: C6557 + term_version: 20.05a + +"95603": + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +"95613": + common: + description: >- + A malignant peripheral nerve sheath tumor which shows rhabdomyosarcomatous differentiation. + More than half of the patients have neurofibromatosis type 1. The prognosis + is usually poor. + termDef: + term: >- + Malignant Triton Tumor + source: NCIt + cde_id: C4335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4335" + term_id: C4335 + term_version: 20.05a + +"95620": + common: + description: >- + A benign neoplasm arising from nerve sheaths. It is characterized by the presence + of a myxoid stroma. + termDef: + term: >- + Nerve Sheath Myxoma + source: NCIt + cde_id: C7018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7018" + term_id: C7018 + term_version: 20.05a + +"95700": + common: + description: >- + A tumor that grows from a nerve or is composed of nerve cells and nerve fibers. + termDef: + term: >- + Neuroma + source: NCIt + cde_id: C3275 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3275" + term_id: C3275 + term_version: 20.05a + +"95710": + common: + description: >- + A rare benign tumor composed entirely of neoplastic perineurial cells. It may + occur in the soft tissues, intraneurally or in mucosal sites. + termDef: + term: >- + Perineurioma + source: NCIt + cde_id: 'C4973 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4973 " + term_id: 'C4973 ' + term_version: 20.05a + +"95713": + common: + description: >- + A very rare malignant tumor with morphologic features similar to those of benign + perineurioma of soft tissue along with hypercellularity, nuclear atypia, hyperchromasia, + and a high mitotic rate. + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor with Perineurial Differentiation + source: NCIt + cde_id: C66845 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66845" + term_id: C66845 + term_version: 20.05a + +"95800": + common: + description: >- + An unusual benign or malignant neoplasm characterized by the presence of neoplastic + large polygonal cells with granular, eosinophilic cytoplasm which contains abundant + lysosomes. It was originally thought to be a tumor originating from muscle cells + and was named granular cell myoblastoma. Subsequent studies have suggested a + derivation from Schwann cells. It affects females more often than males and + it usually presents as a solitary mass. A minority of patients have multiple + tumors. It can arise from many anatomic sites including the posterior pituitary + gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast. + termDef: + term: >- + Granular Cell Tumor + source: NCIt + cde_id: C3474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3474" + term_id: C3474 + term_version: 20.05a + +"95803": + common: + description: >- + An uncommon granular cell tumor which may metastasize to other anatomic sites. + Morphologic characteristics include the presence of spindling neoplastic cells, + necrosis, extensive pleomorphism, prominent nucleoli, and increased mitiotic + activity. + termDef: + term: >- + Malignant Granular Cell Tumor + source: NCIt + cde_id: C4336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4336" + term_id: C4336 + term_version: 20.05a + +"95813": + common: + description: >- + A rare malignant neoplasm characterized by the presence of large epithelioid + cells with abundant cytoplasm forming nests and pseudoalveolar structures. The + groups of the epithelioid cells are separated by thin-walled sinusoidal spaces. + It occurs most often in adolescents and young adults. In adults the most common + sites of involvement are the extremities, and in infants and children, the head + and neck. It usually presents as a slowly growing mass and it frequently metastasizes + to other anatomic sites. The most common sites of metastasis are the lungs, + bone, and brain. + termDef: + term: >- + Alveolar Soft Part Sarcoma + source: NCIt + cde_id: C3750 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3750" + term_id: C3750 + term_version: 20.05a + +"95903": + common: + description: >- + A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which + involves the lymph nodes, bone marrow and/or extranodal sites. This category + includes Non-Hodgkin lymphomas and Hodgkin lymphomas. + termDef: + term: >- + Lymphoma + source: NCIt + cde_id: 'C3208 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3208 " + term_id: 'C3208 ' + term_version: 20.05a + +"95913": + common: + description: >- + Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin + lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can + occur at any age, and usually presents as a localized or generalized lymphadenopathy + associated with fever and weight loss. The clinical course varies according + to the morphologic type. NHL is clinically classified as indolent, aggressive, + or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage. + termDef: + term: >- + Non-Hodgkin Lymphoma + source: NCIt + cde_id: 'C3211 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3211 " + term_id: 'C3211 ' + term_version: 20.05a + +"95963": + common: + description: >- + Coexistence of Hodgkin and non-Hodgkin lymphoma in the same anatomic site. + termDef: + term: >- + Composite Lymphoma + source: NCIt + cde_id: 'C38661 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38661 " + term_id: 'C38661 ' + term_version: 20.05a + +"95973": + common: + description: >- + A primary lymphoma of the skin composed of various numbers of small and large + irregular neoplastic follicle center cells. Its morphologic pattern can be + nodular, diffuse, or nodular and diffuse. It presents with solitary or grouped + plaques and tumors, and it usually involves the scalp, forehead, or trunk. It + rarely involves the legs. This type of cutaneous lymphoma tends to remain localized + to the skin. + termDef: + term: >- + Primary Cutaneous Follicle Center Lymphoma + source: NCIt + cde_id: C7217 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7217" + term_id: C7217 + term_version: 20.05a + +"96503": + common: + description: >- + A lymphoma, previously known as Hodgkin's disease, characterized by the presence + of large tumor cells in an abundant admixture of nonneoplastic cells. There + are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and + classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. + termDef: + term: >- + Hodgkin Lymphoma + source: NCIt + cde_id: C9357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9357" + term_id: C9357 + term_version: 20.05a + +"96513": + common: + description: >- + A subtype of classic Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg + cells and a nodular or less often diffuse cellular background consisting of + small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, + 2008) + termDef: + term: >- + Lymphocyte-Rich Classic Hodgkin Lymphoma + source: NCIt + cde_id: 'C6913 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6913 " + term_id: 'C6913 ' + term_version: 20.05a + +"96523": + common: + description: >- + A subtype of classic Hodgkin lymphoma with scattered Reed-Sternberg and Hodgkin + cells in a diffuse or vaguely nodular mixed inflammatory background without + nodular sclerosing fibrosis. (WHO, 2008) + termDef: + term: >- + Mixed Cellularity Classic Hodgkin Lymphoma + source: NCIt + cde_id: C3517 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3517" + term_id: C3517 + term_version: 20.05a + +"96533": + common: + description: >- + A diffuse subtype of classic Hodgkin lymphoma which is rich in Hodgkin and Reed-Sternberg + cells and/or depleted in non-neoplastic lymphocytes. (WHO, 2008) + termDef: + term: >- + Lymphocyte-Depleted Classic Hodgkin Lymphoma + source: NCIt + cde_id: C9283 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9283" + term_id: C9283 + term_version: 20.05a + +"96593": + common: + description: >- + A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse + proliferation of scattered large neoplastic cells known as popcorn or lymphocyte + predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or + histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in + nearly all instances. Patients are predominantly male, frequently in the 30-50 + year age group. Most patients present with limited stage disease (localized + peripheral lymphadenopathy, stage I or II). (WHO 2008) + termDef: + term: >- + Nodular Lymphocyte Predominant Hodgkin Lymphoma + source: NCIt + cde_id: 'C7258 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7258 " + term_id: 'C7258 ' + term_version: 20.05a + +"96613": + common: + description: >- + An obsolete term that refers to cases of Hodgkin lymphoma excluding cases that + were classified as Hodgkin's paragranuloma and Hodgkin's sarcoma. + termDef: + term: >- + Hodgkin's Granuloma + source: NCIt + cde_id: C6914 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6914" + term_id: C6914 + term_version: 20.05a + +"96623": + common: + description: >- + A lymphoma, previously known as Hodgkin's disease, characterized by the presence + of large tumor cells in an abundant admixture of nonneoplastic cells. There + are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and + classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. + termDef: + term: >- + Hodgkin Lymphoma + source: NCIt + cde_id: C9357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9357" + term_id: C9357 + term_version: 20.05a + +"96633": + common: + description: >- + A subtype of classic Hodgkin lymphoma characterized by collagen bands that surround + at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type + morphology. (WHO, 2008) + termDef: + term: >- + Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: C3518 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3518" + term_id: C3518 + term_version: 20.05a + +"96643": + common: + description: >- + A nodular sclerosis Hodgkin lymphoma characterized by the presence of lacunar + cells, nodular growth, and the absence of fibrosis. + termDef: + term: >- + Nodular Sclerosis Classic Hodgkin Lymphoma, Cellular Phase + source: NCIt + cde_id: C67171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67171" + term_id: C67171 + term_version: 20.05a + +"96653": + common: + description: >- + Nodular sclerosis Hodgkin lymphoma in which at least 75% of the tumor nodules + contain scattered Reed-Sternberg cells. The background cellular infiltrate is + lymphocytic, mixed, or fibrohistiocytic. + termDef: + term: >- + Grade 1 Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: 'C7165 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7165 " + term_id: 'C7165 ' + term_version: 20.05a + +"96673": + common: + description: >- + Nodular sclerosis Hodgkin lymphoma in which at least 25% of the tumor nodules + contain increased numbers of Reed-Sternberg cells. + termDef: + term: >- + Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: 'C7166 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7166 " + term_id: 'C7166 ' + term_version: 20.05a + +"96703": + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +"96713": + common: + description: >- + A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma + cells involving the bone marrow, lymph nodes, and the spleen. The majority of + patients have a serum IgM paraprotein. + termDef: + term: >- + Lymphoplasmacytic Lymphoma + source: NCIt + cde_id: 'C3212 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3212 " + term_id: 'C3212 ' + term_version: 20.05a + +"96733": + common: + description: >- + An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium + sized B-lymphocytes (centrocytes). Most patients present with advanced stage + disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The + gastrointestinal tract is the most commonly affected extranodal site by this + type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) + resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin + D1 mRNA. + termDef: + term: >- + Mantle Cell Lymphoma + source: NCIt + cde_id: 'C4337 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4337 " + term_id: 'C4337 ' + term_version: 20.05a + +"96753": + common: + description: >- + Diffuse Centroblastic-Centrocytic Lymphoma + termDef: + term: >- + Diffuse Centroblastic-Centrocytic Lymphoma + source: NCIt + cde_id: C4338 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4338" + term_id: C4338 + term_version: 20.05a + +"96783": + common: + description: >- + A large B-cell lymphoma usually presenting as a serous effusion without detectable + tumor masses. It is universally associated with human herpes virus 8 (HHV8), + also called Kaposi sarcoma-associated herpesvirus. It mostly occurs in the + setting of immunodeficiency. The most common sites of involvement are the pleural, + pericardial, and peritoneal cavities. Rare HHV8-positive lymphomas indistinguishable + from primary effusion lymphomas (PEL) present as solid tumor masses, and have + been termed extracavitary PEL. The prognosis is extremely unfavorable. (WHO + 2017) + termDef: + term: >- + Primary Effusion Lymphoma + source: NCIt + cde_id: C6915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6915" + term_id: C6915 + term_version: 20.05a + +"96793": + common: + description: >- + A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically + it is characterized by a massive diffuse lymphocytic proliferation associated + with compartmentalizing fibrosis. Response to intensive chemotherapy, with + or without radiotherapy, is usually good. (WHO, 2001) + termDef: + term: >- + Primary Mediastinal (Thymic) Large B-Cell Lymphoma + source: NCIt + cde_id: C9280 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9280" + term_id: C9280 + term_version: 20.05a + +"96803": + common: + description: >- + A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly + large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin + lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic + lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities + include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large + B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary + cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell + lymphoma. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma + source: NCIt + cde_id: 'C8851 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8851 " + term_id: 'C8851 ' + term_version: 20.05a + +"96843": + common: + description: >- + A diffuse large B-cell lymphoma characterized by the presence of immunoblasts + with uniformly round-to-oval nuclei, a prominent nucleolus, and abundant cytoplasm. + termDef: + term: >- + Immunoblastic Lymphoma + source: NCIt + cde_id: C3461 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3461" + term_id: C3461 + term_version: 20.05a + +"96873": + common: + description: >- + A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with + basophilic cytoplasm and numerous mitotic figures. It is often associated with + the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three + morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma + with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All + cases express the MYC translocation [t(8;14)]. (WHO, 2001) + termDef: + term: >- + Burkitt Lymphoma + source: NCIt + cde_id: 'C2912 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2912 " + term_id: 'C2912 ' + term_version: 20.05a + +"96883": + common: + description: >- + A large B-cell lymphoma characterized by the presence of a limited number of + scattered neoplastic large B-lymphocytes which are admixed with numerous non-neoplastic + T-lymphocytes and frequently histiocytes. + termDef: + term: >- + T-Cell/Histiocyte-Rich Large B-Cell Lymphoma + source: NCIt + cde_id: C9496 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9496" + term_id: C9496 + term_version: 20.05a + +"96893": + common: + description: >- + A B-cell non-Hodgkin lymphoma composed of small lymphocytes which surround and + replace the splenic white pulp germinal centers. It involves the spleen and + splenic hilar lymph nodes, bone marrow, and often the peripheral blood. When + lymphoma cells are present in the peripheral blood, they are usually, but not + always, characterized by the presence of short polar villi. (WHO) + termDef: + term: >- + Splenic Marginal Zone Lymphoma + source: NCIt + cde_id: C4663 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4663" + term_id: C4663 + term_version: 20.05a + +"96903": + common: + description: >- + A neoplasm of follicle centre B cells which has at least a partial follicular + pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas + in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, + follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending + on the percentage of the large lymphocytes present. The vast majority of cases + (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates + with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade + 3 is more aggressive (adapted from WHO, 2001). + termDef: + term: >- + Follicular Lymphoma + source: NCIt + cde_id: C3209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3209" + term_id: C3209 + term_version: 20.05a + +"96913": + common: + description: >- + A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic + field. + termDef: + term: >- + Grade 2 Follicular Lymphoma + source: NCIt + cde_id: C8968 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8968" + term_id: C8968 + term_version: 20.05a + +"96953": + common: + description: >- + A follicular lymphoma which contains up to 5 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 1 Follicular Lymphoma + source: NCIt + cde_id: C3465 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3465" + term_id: C3465 + term_version: 20.05a + +"96983": + common: + description: >- + A follicular lymphoma which contains more than 15 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 3 Follicular Lymphoma + source: NCIt + cde_id: 'C3460 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3460 " + term_id: 'C3460 ' + term_version: 20.05a + +"96993": + common: + description: >- + A usually indolent mature B-cell lymphoma, arising from the marginal zone of + lymphoid tissues. It is characterized by the presence of small to medium sized + atypical lymphocytes. It comprises three entities, according to the anatomic + sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated + lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, + and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph + nodes without evidence of extranodal disease; and splenic marginal zone B-cell + lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, + and often the peripheral blood. + termDef: + term: >- + Marginal Zone Lymphoma + source: NCIt + cde_id: 'C4341 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4341 " + term_id: 'C4341 ' + term_version: 20.05a + +"97003": + common: + description: >- + A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques. + It is characterized by epidermal and dermal infiltration of small to medium-sized + T-cells with cerebriform nuclei. Patients with limited disease generally have + an excellent prognosis. In the more advanced stages, the prognosis is poor. + (WHO, 2001) + termDef: + term: >- + Mycosis Fungoides + source: NCIt + cde_id: 'C3246 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3246 " + term_id: 'C3246 ' + term_version: 20.05a + +"97013": + common: + description: >- + A generalized peripheral (mature) T-cell neoplasm characterized by the presence + of erythroderma, lymphadenopathy, and neoplastic, cerebriform T-lymphocytes + in the blood. Sezary syndrome is an aggressive disease. (WHO, 2001) + termDef: + term: >- + Sezary Syndrome + source: NCIt + cde_id: C3366 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3366" + term_id: C3366 + term_version: 20.05a + +"97023": + common: + description: >- + A heterogenous category of nodal and extranodal mature T-cell lymphomas that + do not correspond to any of the specifically defined entities of mature T-cell + lymphoma in the 2017 WHO classification. Excluded from this category are tumors + with a T follicular helper (TFH) cell phenotype. Variants include lymphoepithelioid + lymphoma (Lennert lymphoma) and primary EBV-positive nodal T-cell or NK-cell + lymphoma. The follicular variant included in the peripheral T-cell lymphomas, + not otherwise specified, in the 2008 edition of the WHO classification has been + moved to the category of angioimmunoblastic T-cell lymphoma and other nodal + lymphomas of T follicular helper cell origin in the 2017 WHO update. The same + is true for a proportion of cases previously designated as the T-zone variant, + because they usually have a TFH-cell phenotype. (WHO 2017) + termDef: + term: >- + Peripheral T-Cell Lymphoma, Not Otherwise Specified + source: NCIt + cde_id: 'C4340 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4340 " + term_id: 'C4340 ' + term_version: 20.05a + +"97053": + common: + description: >- + A peripheral T-cell lymphoma of mature T follicular helper (TFH) cells characterized + by systemic disease and a polymorphous infiltrate involving lymph nodes, with + a prominent proliferation of high endothelial venules and follicular dendritic + cells. EBV-positive cells are nearly always present. It is a clinically aggressive + lymphoma and seen mainly in older adults. (WHO 2017) + termDef: + term: >- + Angioimmunoblastic T-Cell Lymphoma + source: NCIt + cde_id: C7528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7528" + term_id: C7528 + term_version: 20.05a + +"97083": + common: + description: >- + A cytotoxic primary cutaneous T-cell lymphoma. Recent studies suggest there + are at least two groups of subcutaneous panniculitis-like T-cell lymphomas, + each with distinct histologic features, immunophenotypic profile, and prognosis. + One group has an alpha/beta, CD8 positive phenotype, involves only subcutaneous + tissues, and usually has an indolent clinical course. The second group has a + gamma/delta phenotype, is CD8 negative, often co-expresses CD56, is not confined + to the subcutaneous tissues, and usually has a poor prognosis. In the recent + WHO-EORTC classification, the term subcutaneous panniculitis-like T-cell lymphoma + is reserved for cases with an alpha/beta, CD8 positive phenotype. Cases with + a gamma/delta phenotype are included in the group of cutaneous gamma/delta T-cell + lymphomas. + termDef: + term: >- + Subcutaneous Panniculitis-Like T-Cell Lymphoma + source: NCIt + cde_id: C6918 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6918" + term_id: C6918 + term_version: 20.05a + +"97093": + common: + description: >- + A T-cell non-Hodgkin lymphoma arising from the skin. Representative examples + include mycosis fungoides and primary cutaneous anaplastic large cell lymphoma. + termDef: + term: >- + Primary Cutaneous T-Cell Non-Hodgkin Lymphoma + source: NCIt + cde_id: 'C3467 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3467 " + term_id: 'C3467 ' + term_version: 20.05a + +"97123": + common: + description: >- + A rare extranodal B-cell non-Hodgkin lymphoma, characterized by the presence + of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries. This + is an extremely aggressive lymphoma which responds poorly to chemotherapy. (WHO, + 2001) + termDef: + term: >- + Intravascular Large B-Cell Lymphoma + source: NCIt + cde_id: C4342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4342" + term_id: C4342 + term_version: 20.05a + +"97143": + common: + description: >- + A T-cell peripheral lymphoma composed of usually large, pleomorphic, CD30 positive + T-lymphocytes with abundant cytoplasm characterized by the presence of a translocation + involving the ALK gene and expression of ALK fusion protein. Most patients + present with peripheral and/or abdominal lymphadenopathy, and often have advanced + disease and extranodal involvement. + termDef: + term: >- + Anaplastic Large Cell Lymphoma, ALK-Positive + source: NCIt + cde_id: 'C37193 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37193 " + term_id: 'C37193 ' + term_version: 20.05a + +"97163": + common: + description: >- + An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic + T-cells, usually of gamma/delta T-cell type. It is characterized by the presence + of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A + similar infiltrating pattern is also present in the spleen and bone marrow that + are usually involved at the time of the diagnosis. + termDef: + term: >- + Hepatosplenic T-Cell Lymphoma + source: NCIt + cde_id: C8459 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8459" + term_id: C8459 + term_version: 20.05a + +"97173": + common: + description: >- + A mature T-cell and NK-cell non-Hodgkin lymphoma of intraepithelial T-lymphocytes. + It usually arises from the small intestine, most commonly the jejunum or ileum. Other + less frequent primary anatomic sites include the duodenum, stomach, colon, or + outside the gastrointestinal tract. It is characterized by the presence of pleomorphic + medium-sized to large T-lymphocytes with vesicular nuclei, prominent nucleoli, + and moderate to abundant pale cytoplasm. It is associated with celiac disease. + termDef: + term: >- + Enteropathy-Associated T-Cell Lymphoma + source: NCIt + cde_id: C4737 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4737" + term_id: C4737 + term_version: 20.05a + +"97183": + common: + description: >- + This entity represents a spectrum of lymphoproliferative disorders characterized + by CD30 (Ki-1)-positive cutaneous T-cell infiltrates. The two ends of the spectrum + include lymphomatoid papulosis (benign end) and primary cutaneous anaplastic + large cell lymphoma (malignant end). Borderline lesions are also included in + this spectrum. (WHO, 2001) + termDef: + term: >- + Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder + source: NCIt + cde_id: 'C7195 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7195 " + term_id: 'C7195 ' + term_version: 20.05a + +"97193": + common: + description: >- + An aggressive, predominantly extranodal, mature T-cell non-Hodgkin lymphoma. + It is characterized by an often angiocentric and angiodestructive cellular infiltrate + composed of EBV positive NK/T cells. The nasal cavity is the most common site + of involvement. Patients often present with midfacial destructive lesions (lethal + midline granuloma). The disease may disseminate rapidly to various anatomic + sites including the gastrointestinal tract, skin, testis, and cervical lymph + nodes. It is also known as angiocentric T-cell lymphoma. The term "polymorphic + reticulosis" has been widely used to describe the morphologic changes seen in + this type of lymphoma. However, the latter term may also apply to lymphomatoid + granulomatosis, which is an angiocentric and angiodestructive EBV positive B-cell + lymphoproliferative disorder. + termDef: + term: >- + Nasal Type Extranodal NK/T-Cell Lymphoma + source: NCIt + cde_id: 'C4684 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4684 " + term_id: 'C4684 ' + term_version: 20.05a + +"97243": + common: + description: >- + An aggressive and life-threatening, EBV-positive T-cell lymphoma affecting children. It + is more prevalent in Taiwan and Japan. Clinically, it presents with acute onset + of fever and generalized malaise, followed by hepatosplenomegaly and liver failure. Morphologically + it is characterized by the presence of infiltrating T-lymphocytes which are + usually small and erythrophagocytosis. Most patients have a fulminant clinical + course. + termDef: + term: >- + Systemic EBV-Positive T-Cell Lymphoma of Childhood + source: NCIt + cde_id: C80374 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80374" + term_id: C80374 + term_version: 20.05a + +"97253": + common: + description: >- + A rare, EBV-positive cutaneous T-cell lymphoproliferative disorder, composed + of CD8 positive cytotoxic T-lymphocytes. It affects children, almost exclusively + in Latin America and Asia. Patients present with papulovesicular skin lesions, + clinically resembling hydroa vacciniforme, in areas of sun-exposed skin. + termDef: + term: >- + Hydroa Vacciniforme-Like Lymphoproliferative Disorder + source: NCIt + cde_id: C45327 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45327" + term_id: C45327 + term_version: 20.05a + +"97263": + common: + description: >- + An aggressive cutaneous lymphoma of mature, activated gamma/delta T-lymphocytes. It + usually presents with disseminated plaques and nodules. Involvement of mucosal + sites is frequent. However, involvement of lymph nodes, spleen, or bone marrow + is uncommon. Morphologically, there are three patterns of cutaneous involvement: + epidermotropic, dermal, and subcutaneous. Often, more than one pattern may + co-exist in a single biopsy specimen, or may be present in different biopsy + specimens from the same patient. The lymphocytic infiltrate is composed of + medium- to large-sized lymphocytes expressing CD56. Most cases lack both CD4 + and CD8, although CD8 may be present in some cases. This group of lymphomas + includes cases previously known as subcutaneous panniculitis-like T-cell lymphoma + with a gamma/delta phenotype. + termDef: + term: >- + Primary Cutaneous Gamma-Delta T-Cell Lymphoma + source: NCIt + cde_id: C45340 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45340" + term_id: C45340 + term_version: 20.05a + +"97273": + common: + description: >- + A lymphoma composed of immature small to medium-sized precursor lymphoid cells + (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma. + termDef: + term: >- + Lymphoblastic Lymphoma + source: NCIt + cde_id: 'C9360 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9360 " + term_id: 'C9360 ' + term_version: 20.05a + +"97293": + common: + description: >- + The most frequent type of lymphoblastic lymphoma. It comprises approximately + 85-90% of cases. It is more frequently seen in adolescent males. It frequently + presents with a mass lesion in the mediastinum. Pleural effusions are common. (WHO, + 2001) + termDef: + term: >- + T Lymphoblastic Lymphoma + source: NCIt + cde_id: C6919 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6919" + term_id: C6919 + term_version: 20.05a + +"97313": + common: + description: >- + A malignant (clonal) proliferation of plasma cells that are cytologically and + immunophenotypically identical to those of plasma cell myeloma, but manifest + a localized osseous or extraosseous growth pattern. (WHO, 2001) + termDef: + term: >- + Plasmacytoma + source: NCIt + cde_id: 'C9349 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9349 " + term_id: 'C9349 ' + term_version: 20.05a + +"97323": + common: + description: >- + A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal + protein and skeletal destruction with osteolytic lesions, pathological fractures, + bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory + myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, + 2001) + termDef: + term: >- + Plasma Cell Myeloma + source: NCIt + cde_id: C3242 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3242" + term_id: C3242 + term_version: 20.05a + +"97333": + common: + description: >- + An aggressive plasma cell neoplasm characterized by the presence of neoplastic + plasma cells in the peripheral blood. It is characterized by the presence of + a circulating clonal plasma cell count that exceeds 2x10^9/L or is 20% of the + leukocyte differential count. + termDef: + term: >- + Plasma Cell Leukemia + source: NCIt + cde_id: C3180 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3180" + term_id: C3180 + term_version: 20.05a + +"97343": + common: + description: >- + A plasma cell neoplasm arising at an extraosseous site. There is no involvement + of the bone marrow. It most frequently involves the oropharynx, nasopharynx, + sinuses, and larynx. Other sites of involvement include the gastrointestinal + tract, central nervous system, breast, skin, lymph nodes, and bladder. A minority + of patients have a monoclonal gammopathy. Treatment includes radiation therapy. + Progression to plasma cell myeloma occurs in a minority of patients. + termDef: + term: >- + Extraosseous Plasmacytoma + source: NCIt + cde_id: C4002 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4002" + term_id: C4002 + term_version: 20.05a + +"97353": + common: + description: >- + An aggressive diffuse large B-cell lymphoma frequently arising in the setting + of HIV infection and characterized by the presence of large neoplastic cells + resembling B-immunoblasts which have the immunophenotypic profile of plasma + cells. Sites of involvement include the oral cavity, sinonasal cavity, skin, + soft tissues, gastrointestinal tract, and bone. + termDef: + term: >- + Plasmablastic Lymphoma + source: NCIt + cde_id: C7224 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7224" + term_id: C7224 + term_version: 20.05a + +"97373": + common: + description: >- + A usually aggressive large B-cell lymphoma characterized by the presence of + monomorphic immunoblast-like neoplastic B-lymphocytes in a sinusoidal growth + pattern. The neoplastic B-lymphocytes express the ALK kinase but they lack + the 2;5 translocation. + termDef: + term: >- + ALK-Positive Large B-Cell Lymphoma + source: NCIt + cde_id: C7225 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7225" + term_id: C7225 + term_version: 20.05a + +"97383": + common: + description: >- + An aggressive diffuse large B-cell lymphoma occurring in patients with HHV8-positive + multicentric Castleman disease. It is characterized by the presence of human + herpesvirus 8-infected large B-lymphocytes that resemble plasmablasts. It is + usually seen in patients with HIV infection. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman + Disease + source: NCIt + cde_id: C27856 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27856" + term_id: C27856 + term_version: 20.05a + +"97401": + common: + description: >- + A localized tumor composed of sheets of mast cells without atypia. It includes + the cutaneous mastocytoma which involves the dermis and subcutaneous tissue, + and the extracutaneous mastocytoma. Most cases of extracutaneous mastocytoma + have been reported in the lung. + termDef: + term: >- + Mastocytoma + source: NCIt + cde_id: 'C9303 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9303 " + term_id: 'C9303 ' + term_version: 20.05a + +"97403": + common: + description: >- + A rare malignant neoplasm characterized by localized but destructive growth + of a tumor consisting of highly atypical, immature mast cells.(WHO, 2001) + termDef: + term: >- + Mast Cell Sarcoma + source: NCIt + cde_id: C9348 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9348" + term_id: C9348 + term_version: 20.05a + +"97411": + common: + description: >- + An indolent mast cell neoplasm characterized by systemic infiltration of skin + and internal organs by aggregates of neoplastic mast cells. There is no evidence + of mast cell leukemia or clonal hematologic malignancy. Clinically, there is + no evidence of palpable hepatomegaly and splenomegaly, malabsorption syndrome, + or pathologic fractures. + termDef: + term: >- + Indolent Systemic Mastocytosis + source: NCIt + cde_id: C9286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9286" + term_id: C9286 + term_version: 20.05a + +"97413": + common: + description: >- + Malignant neoplasm originating from mast cells. + termDef: + term: >- + Malignant Mastocytosis + source: NCIt + cde_id: 'C8991 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8991 " + term_id: 'C8991 ' + term_version: 20.05a + +"97423": + common: + description: >- + A variant of systemic mastocytosis with involvement of the bone marrow (20% + or more mast cells) and the peripheral blood (mast cells account for 10% or + more of peripheral blood white cells). (WHO, 2001) + termDef: + term: >- + Mast Cell Leukemia + source: NCIt + cde_id: C3169 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3169" + term_id: C3169 + term_version: 20.05a + +"97503": + common: + description: >- + An antiquated term referring to cases of systemic non-Hodgkin lymphomas which + are composed of large, atypical neoplastic lymphoid cells and cases of hemophagocytic + syndromes. In the past, cases of anaplastic large cells lymphoma were called + malignant histiocytosis. + termDef: + term: >- + Malignant Histiocytosis + source: NCIt + cde_id: 'C7202 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7202 " + term_id: 'C7202 ' + term_version: 20.05a + +"97513": + common: + description: >- + A neoplastic proliferation of Langerhans cells which contain Birbeck granules + by ultrastructural examination. Three major overlapping syndromes are recognized: + eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. + The clinical course is generally related to the number of organs affected at + presentation. (WHO, 2001) + termDef: + term: >- + Langerhans Cell Histiocytosis + source: NCIt + cde_id: 'C3107 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3107 " + term_id: 'C3107 ' + term_version: 20.05a + +"97553": + common: + description: >- + An aggressive malignant neoplasm with a poor response to therapy, usually presenting + as stage III/IV disease. It is characterized by the presence of neoplastic cells + with morphologic and immunophenotypic characteristics similar to those seen + in mature histiocytes. + termDef: + term: >- + Histiocytic Sarcoma + source: NCIt + cde_id: C27349 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27349" + term_id: C27349 + term_version: 20.05a + +"97563": + common: + description: >- + A neoplastic proliferation of Langerhans cells with overtly malignant cytologic + features. It can be considered a higher grade variant of Langerhans cell histiocytosis + (LCH) and it can present de novo or progress from antecedent LCH. (WHO, 2001) + termDef: + term: >- + Langerhans Cell Sarcoma + source: NCIt + cde_id: C6921 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6921" + term_id: C6921 + term_version: 20.05a + +"97573": + common: + description: >- + A neoplastic proliferation of spindle to ovoid cells which show phenotypic features + similar to those of interdigitating dendritic cells. The clinical course is + generally aggressive. (WHO, 2008) + termDef: + term: >- + Interdigitating Dendritic Cell Sarcoma + source: NCIt + cde_id: 'C9282 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9282 " + term_id: 'C9282 ' + term_version: 20.05a + +"97583": + common: + description: >- + A neoplasm composed of spindle to ovoid cells which have morphologic and immunophenotypic + characteristics of follicular dendritic cells. It affects lymph nodes and other + sites including the tonsils, gastrointestinal tract, spleen, liver, soft tissues, + skin, and oral cavity. It usually behaves as a low grade sarcoma. Treatment + options include complete surgical removal of the tumor with or without adjuvant + chemotherapy or radiotherapy. Recurrences have been reported in up to half of + the cases. + termDef: + term: >- + Follicular Dendritic Cell Sarcoma + source: NCIt + cde_id: C9281 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9281" + term_id: C9281 + term_version: 20.05a + +"97593": + common: + description: >- + A very rare dendritic cell tumor affecting the lymph nodes, spleen, and soft + tissues. Morphologically it is similar to the interdigitating dendritic cell + sarcoma or follicular dendritic cell sarcoma. The tumor cells are positive for + cytokeratin and CD68. Clinical outcome is variable. + termDef: + term: >- + Fibroblastic Reticular Cell Tumor + source: NCIt + cde_id: C81758 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81758" + term_id: C81758 + term_version: 20.05a + +"97613": + common: + description: >- + Lymphoplasmacytic lymphoma associated with bone marrow involvement and IgM monoclonal + gammopathy. + termDef: + term: >- + Waldenstrom Macroglobulinemia + source: NCIt + cde_id: C80307 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80307" + term_id: C80307 + term_version: 20.05a + +"97623": + common: + description: >- + A group of rare disorders of immunoglobulin synthesis associated with B-cell + proliferative disorders. + termDef: + term: >- + Heavy Chain Disease + source: NCIt + cde_id: 'C3082 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3082 " + term_id: 'C3082 ' + term_version: 20.05a + +"97643": + common: + description: >- + A clonal disorder, also known as immunoproliferative small intestinal disease + or Mediterranean lymphoma, characterised by the secretion of a defective alpha + heavy chain. It predominantly affects young people in the Mediterranean region. It + involves the small intestine, and patients usually present with malabsorption + syndrome, abdominal pain, weight loss, and fever. There is extensive villous + atrophy of the small intestinal mucosa, which is heavily infiltrated by small + lymphocytes and plasma cells. The small intestinal morphologic changes are + consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). + termDef: + term: >- + Alpha Heavy Chain Disease + source: NCIt + cde_id: C3132 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3132" + term_id: C3132 + term_version: 20.05a + +"97651": + common: + description: >- + A condition in which an abnormal amount of a single immunoglobulin is present + in the serum. This category includes IgM monoclonal gammopathy of undetermined + significance and non-IgM monoclonal gammopathy of undetermined significance. + Up to 25% of cases of monoclonal gammopathy of undetermined significance progress + to a B-cell malignancy or myeloma. + termDef: + term: >- + Monoclonal Gammopathy of Undetermined Significance + source: NCIt + cde_id: C3996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3996" + term_id: C3996 + term_version: 20.05a + +"97661": + common: + description: >- + A neoplastic lymphoproliferative process characterized by an angiocentric arrangement + of the tumor cells which is associated with angiodestruction. It includes lymphomatoid + granulomatosis which is a lymphoproliferative lesion derived from mature B-lymphocytes + and cases of extranodal NK/T-cell lymphomas of nasal type. + termDef: + term: >- + Angiocentric Immunoproliferative Lesion + source: NCIt + cde_id: 'C40970 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40970 " + term_id: 'C40970 ' + term_version: 20.05a + +"97671": + common: + description: >- + A peripheral T-cell lymphoma of mature T follicular helper (TFH) cells characterized + by systemic disease and a polymorphous infiltrate involving lymph nodes, with + a prominent proliferation of high endothelial venules and follicular dendritic + cells. EBV-positive cells are nearly always present. It is a clinically aggressive + lymphoma and seen mainly in older adults. (WHO 2017) + termDef: + term: >- + Angioimmunoblastic T-Cell Lymphoma + source: NCIt + cde_id: C7528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7528" + term_id: C7528 + term_version: 20.05a + +"97681": + common: + description: >- + A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase + in the number of peripheral blood large granular lymphocytes, without a clearly + identified cause. (WHO, 2001) + termDef: + term: >- + T-Cell Large Granular Lymphocyte Leukemia + source: NCIt + cde_id: C4664 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4664" + term_id: C4664 + term_version: 20.05a + +"97691": + common: + description: >- + A plasma cell neoplasm that secretes an abnormal immunoglobulin, which deposits + in tissues and forms a beta-pleated sheet structure that binds Congo red dye + with characteristic birefringence. (WHO, 2001) + termDef: + term: >- + Primary Amyloidosis + source: NCIt + cde_id: 'C3819 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3819 " + term_id: 'C3819 ' + term_version: 20.05a + +"98003": + common: + description: >- + A malignant (clonal) hematologic disorder, involving hematopoietic stem cells + and characterized by the presence of primitive or atypical myeloid or lymphoid + cells in the bone marrow and the blood. Leukemias are classified as acute or + chronic based on the degree of cellular differentiation and the predominant + cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic + episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, + chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic + leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; + untreated, the natural course of acute leukemias is normally measured in weeks + or months, while that of chronic leukemias is more often measured in months + or years. + termDef: + term: >- + Leukemia + source: NCIt + cde_id: 'C3161 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3161 " + term_id: 'C3161 ' + term_version: 20.05a + +"98013": + common: + description: >- + A clonal (malignant) hematopoietic disorder with an acute onset, affecting the + bone marrow and the peripheral blood. The malignant cells show minimal differentiation + and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts + (lymphoblasts). + termDef: + term: >- + Acute Leukemia + source: NCIt + cde_id: C9300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9300" + term_id: C9300 + term_version: 20.05a + +"98053": + common: + description: >- + An acute leukemia of ambiguous lineage characterized by blasts which coexpress + myeloid and T or B lineage antigens or concurrent B and T lineage antigens. (WHO, + 2001) + termDef: + term: >- + Acute Biphenotypic Leukemia + source: NCIt + cde_id: 'C4673 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4673 " + term_id: 'C4673 ' + term_version: 20.05a + +"98063": + common: + description: >- + A rare mixed phenotype acute leukemia in which the blasts also carry the translocation + t(9;22)(q34.1;q11.2) by karyotypic analysis or the BCR-ABL1 translocation by + FISH or PCR. The prognosis is usually unfavorable. + termDef: + term: >- + Mixed Phenotype Acute Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 + source: NCIt + cde_id: C82192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82192" + term_id: C82192 + term_version: 20.05a + +"98073": + common: + description: >- + A rare mixed phenotype acute leukemia in which the blasts also carry a translocation + (v; 11q23.3) involving the KMT2A gene. The prognosis is usually unfavorable. + termDef: + term: >- + Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged + source: NCIt + cde_id: C82203 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82203" + term_id: C82203 + term_version: 20.05a + +"98083": + common: + description: >- + A rare mixed phenotype acute leukemia in which the blasts express B-lymphoid + and myeloid lineage markers but are negative for MLL translocation and t(9;22)(q34;q11.2) + translocation. The prognosis is usually unfavorable. + termDef: + term: >- + Mixed Phenotype Acute Leukemia, B/Myeloid, Not Otherwise Specified + source: NCIt + cde_id: C82212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82212" + term_id: C82212 + term_version: 20.05a + +"98093": + common: + description: >- + A rare mixed phenotype acute leukemia in which the blasts express T-lymphoid + and myeloid lineage markers but are negative for MLL translocation and t(9;22)(q34;q11.2) + translocation. The prognosis is usually unfavorable. + termDef: + term: >- + Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified + source: NCIt + cde_id: C82213 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82213" + term_id: C82213 + term_version: 20.05a + +"98113": + common: + description: >- + The term refers to precursor lymphoid neoplasms which are composed of B-lymphoblasts + and characterized by the absence of recurrent genetic abnormalities. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified + source: NCIt + cde_id: C80326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80326" + term_id: C80326 + term_version: 20.05a + +"98123": + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome + 9. It results in the production of the p190 kd or p210 kd fusion protein. It + has an unfavorable clinical outcome. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1 + source: NCIt + cde_id: C80331 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80331" + term_id: C80331 + term_version: 20.05a + +"98133": + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the KMT2A gene at 11q23.3 and another gene partner resulting + in the production of a KMT2A related fusion protein. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged + source: NCIt + cde_id: C80332 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80332" + term_id: C80332 + term_version: 20.05a + +"98143": + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the TEL gene on chromosome 12 and the AML1 gene on chromosome + 21, (p13.2;q22.1). It results in the production of the TEL-AML1 (ETV6-RUNX1) + fusion protein. It has a favorable clinical outcome. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1 + source: NCIt + cde_id: C80334 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80334" + term_id: C80334 + term_version: 20.05a + +"98153": + common: + description: >- + A precursor lymphoid neoplasm composed of B-lymphoblasts which contain more + than 50 and usually less than 66 chromosomes. It has a favorable clinical outcome. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with Hyperdiploidy + source: NCIt + cde_id: C80335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80335" + term_id: C80335 + term_version: 20.05a + +"98163": + common: + description: >- + A precursor lymphoid neoplasm composed of B-lymphoblasts which contain less + than 46 chromosomes. It has an unfavorable clinical outcome. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with Hypodiploidy + source: NCIt + cde_id: C80338 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80338" + term_id: C80338 + term_version: 20.05a + +"98173": + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the IL3 gene on chromosome 5 and the IGH locus on chromosome + 14, (q31.1;q32.3). It results in eosinophilia. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH + source: NCIt + cde_id: C80340 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80340" + term_id: C80340 + term_version: 20.05a + +"98183": + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the E2A gene on chromosome 19 and the PBX1 gene on chromosome + 1. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) + source: NCIt + cde_id: C80341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80341" + term_id: C80341 + term_version: 20.05a + +"98203": + common: + description: >- + A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily + the bone marrow and the peripheral blood. This category includes precursor + or acute lymphoblastic leukemias and chronic leukemias. + termDef: + term: >- + Lymphoid Leukemia + source: NCIt + cde_id: 'C7539 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7539 " + term_id: 'C7539 ' + term_version: 20.05a + +"98233": + common: + description: >- + The most common type of chronic lymphoid leukemia. It comprises 90% of chronic + lymphoid leukemias in the United States. Morphologically, the neoplastic cells + are small, round B-lymphocytes. This type of leukemia is not considered to + be curable with available therapy. (WHO, 2001) + termDef: + term: >- + Chronic Lymphocytic Leukemia + source: NCIt + cde_id: C3163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3163" + term_id: C3163 + term_version: 20.05a + +"98263": + common: + description: >- + The leukemic counterpart of Burkitt's lymphoma. The characteristic Burkitt cells + are seen in the bone marrow and the peripheral blood. This is an aggressive + leukemia. + termDef: + term: >- + Burkitt Leukemia + source: NCIt + cde_id: 'C7400 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7400 " + term_id: 'C7400 ' + term_version: 20.05a + +"98273": + common: + description: >- + A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus + type 1 (HTLV-1). Adult T-cell leukemia/lymphoma is endemic in several regions + of the world, in particular Japan, the Caribbean, and parts of Central Africa. + termDef: + term: >- + Adult T-Cell Leukemia/Lymphoma + source: NCIt + cde_id: C3184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3184" + term_id: C3184 + term_version: 20.05a + +"98313": + common: + description: >- + A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase + in the number of peripheral blood large granular lymphocytes, without a clearly + identified cause. (WHO, 2001) + termDef: + term: >- + T-Cell Large Granular Lymphocyte Leukemia + source: NCIt + cde_id: 'C4664 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4664 " + term_id: 'C4664 ' + term_version: 20.05a + +"98323": + common: + description: >- + A mature B- or T- cell leukemia with progressive clinical course. It is characterized + by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) + in the peripheral blood, bone marrow, and spleen. + termDef: + term: >- + Prolymphocytic Leukemia + source: NCIt + cde_id: C3181 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3181" + term_id: C3181 + term_version: 20.05a + +"98333": + common: + description: >- + A malignant B-cell lymphoproliferative process affecting the blood, bone marrow, + and spleen. The B-prolymphocytes are medium-sized, round lymphoid cells with + prominent nucleoli. The B-prolymphocytes must exceed 55% of lymphoid cells + in the blood. Cases of transformed chronic lymphocytic leukemia (CLL) and CLL + with increased prolymphocytes are excluded. The prognosis is poor. (WHO, 2001) + termDef: + term: >- + B-Cell Prolymphocytic Leukemia + source: NCIt + cde_id: C4753 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4753" + term_id: C4753 + term_version: 20.05a + +"98343": + common: + description: >- + An aggressive T-cell leukemia, characterized by the proliferation of small to + medium sized prolymphocytes with a mature T-cell phenotype, involving the blood, + bone marrow, lymph nodes, liver, spleen, and skin. (WHO, 2001) + termDef: + term: >- + T-Cell Prolymphocytic Leukemia + source: NCIt + cde_id: C4752 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4752" + term_id: C4752 + term_version: 20.05a + +"98353": + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: 'C3167 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167 " + term_id: 'C3167 ' + term_version: 20.05a + +"98363": + common: + description: >- + The most frequent type of acute lymphoblastic leukemia. Approximately 75% of + cases occur in children under six years of age. This is a good prognosis leukemia. In + the pediatric age group the complete remission rate is approximately 95% and + the disease free survival rate is 70%. Approximately 80% of children appear + to be cured. In the adult age group the complete remission rate is 60-85%. (WHO, + 2001) + termDef: + term: >- + B Acute Lymphoblastic Leukemia + source: NCIt + cde_id: 'C8644 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8644 " + term_id: 'C8644 ' + term_version: 20.05a + +"98373": + common: + description: >- + Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood + cases and 25% of adult cases. It is more common in males than females. (WHO, + 2001) + termDef: + term: >- + T Acute Lymphoblastic Leukemia + source: NCIt + cde_id: 'C3183 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3183 " + term_id: 'C3183 ' + term_version: 20.05a + +"98403": + common: + description: >- + An acute myeloid leukemia characterized by a predominant immature erythroid + population. There are two subtypes recognized: erythroleukemia and pure erythroid + leukemia. (WHO, 2001) + termDef: + term: >- + Acute Erythroid Leukemia + source: NCIt + cde_id: 'C8923 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8923 " + term_id: 'C8923 ' + term_version: 20.05a + +"98603": + common: + description: >- + A clonal proliferation of myeloid cells and their precursors in the bone marrow, + peripheral blood, and spleen. When the proliferating cells are immature myeloid + cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating + myeloid cells are neutrophils, it is called chronic myelogenous leukemia. + termDef: + term: >- + Myeloid Leukemia + source: NCIt + cde_id: 'C3172 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3172 " + term_id: 'C3172 ' + term_version: 20.05a + +"98613": + common: + description: >- + Acute myeloid leukemias that do not fulfill the criteria for inclusion in the + group of acute myeloid leukemias which have recurrent genetic abnormalities + or myelodysplastic changes, or are therapy-related. This category includes + entities classified according to the French-American-British classification + scheme. + termDef: + term: >- + Acute Myeloid Leukemia Not Otherwise Specified + source: NCIt + cde_id: 'C27753 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27753 " + term_id: 'C27753 ' + term_version: 20.05a + +"98633": + common: + description: >- + A chronic myeloproliferative neoplasm characterized by the expression of the + BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear + at any age, but it mostly affects middle aged and older individuals. Patients + usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. + If untreated, it follows a biphasic or triphasic natural course; an initial + indolent chronic phase which is followed by an accelerated phase, a blast phase, + or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors + delay disease progression and prolong overall survival. + termDef: + term: >- + Chronic Myelogenous Leukemia, BCR-ABL1 Positive + source: NCIt + cde_id: C3174 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3174" + term_id: C3174 + term_version: 20.05a + +"98653": + common: + description: >- + An acute myeloid leukemia associated with t(6;9)(p23;q34.1) resulting in DEK-NUP214(CAN) + fusion protein expression. It is often associated with multilineage dysplasia + and basophilia. It affects both children and adults and it usually has an unfavorable + clinical outcome. + termDef: + term: >- + Acute Myeloid Leukemia with t(6;9) (p23;q34.1); DEK-NUP214 + source: NCIt + cde_id: C82423 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82423" + term_id: C82423 + term_version: 20.05a + +"98663": + common: + description: >- + An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. + It is characterized by the PML-RARA fusion. There are two variants: the typical + and microgranular variant. This AML is particularly sensitive to treatment + with all trans-retinoic acid and has a favorable prognosis. (WHO) + termDef: + term: >- + Acute Promyelocytic Leukemia with PML-RARA + source: NCIt + cde_id: C3182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3182" + term_id: C3182 + term_version: 20.05a + +"98673": + common: + description: >- + An acute leukemia characterized by the proliferation of both neutrophil and + monocyte precursors. (WHO, 2001) + termDef: + term: >- + Acute Myelomonocytic Leukemia + source: NCIt + cde_id: C7463 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7463" + term_id: C7463 + term_version: 20.05a + +"98693": + common: + description: >- + An acute myeloid leukemia associated with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2) + resulting in the reposition of a distal GATA2 enhancer to activate MECOM expression. + It may present de novo or follow a myelodysplastic syndrome. The clinical course + is aggressive. + termDef: + term: >- + Acute Myeloid Leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2); + GATA2, MECOM + source: NCIt + cde_id: C82426 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82426" + term_id: C82426 + term_version: 20.05a + +"98703": + common: + description: >- + A rare acute myeloid leukemia in which the immature cells differentiate towards + basophils. + termDef: + term: >- + Acute Basophilic Leukemia + source: NCIt + cde_id: C3164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3164" + term_id: C3164 + term_version: 20.05a + +"98713": + common: + description: >- + An acute myeloid leukemia with monocytic and granulocytic differentiation and + the presence of a characteristically abnormal eosinophil component in the bone + marrow. This type of acute myeloid leukemia has a favorable prognosis. (WHO, + 2001) + termDef: + term: >- + Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 + source: NCIt + cde_id: 'C9287 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9287 " + term_id: 'C9287 ' + term_version: 20.05a + +"98723": + common: + description: >- + An acute myeloid leukemia (AML) in which the blasts do not show evidence of + myeloid differentiation by morphology and conventional cytochemistry. (WHO, + 2001) + termDef: + term: >- + Acute Myeloid Leukemia with Minimal Differentiation + source: NCIt + cde_id: 'C8460 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8460 " + term_id: 'C8460 ' + term_version: 20.05a + +"98733": + common: + description: >- + An acute myeloid leukemia (AML) characterized by blasts without evidence of + maturation to more mature neutrophils. (WHO, 2001) + termDef: + term: >- + Acute Myeloid Leukemia without Maturation + source: NCIt + cde_id: C3249 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3249" + term_id: C3249 + term_version: 20.05a + +"98743": + common: + description: >- + An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation + to more mature neutrophils. (WHO, 2001) + termDef: + term: >- + Acute Myeloid Leukemia with Maturation + source: NCIt + cde_id: C3250 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3250" + term_id: C3250 + term_version: 20.05a + +"98753": + common: + description: >- + A chronic myeloproliferative neoplasm characterized by the expression of the + BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear + at any age, but it mostly affects middle aged and older individuals. Patients + usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. + If untreated, it follows a biphasic or triphasic natural course; an initial + indolent chronic phase which is followed by an accelerated phase, a blast phase, + or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors + delay disease progression and prolong overall survival. + termDef: + term: >- + Chronic Myelogenous Leukemia, BCR-ABL1 Positive + source: NCIt + cde_id: 'C3174 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3174 " + term_id: 'C3174 ' + term_version: 20.05a + +"98763": + common: + description: >- + Myelogenous leukemia that is negative for Philadelphia chromosome. + termDef: + term: >- + Philadelphia-Negative Myelogenous Leukemia + source: NCIt + cde_id: C3176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3176" + term_id: C3176 + term_version: 20.05a + +"98913": + common: + description: >- + An acute myeloid leukemia in which the majority of monocytic cells are promonocytes. (WHO, + 2001) + termDef: + term: >- + Acute Monocytic Leukemia + source: NCIt + cde_id: 'C4861 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4861 " + term_id: 'C4861 ' + term_version: 20.05a + +"98953": + common: + description: >- + An acute myeloid leukemia with at least 20% blasts in the bone marrow or blood, + and either a previous history of myelodysplastic syndrome, multilineage dysplasia + or myelodysplastic syndrome-related cytogenetic abnormalities. There is no + history of prior cytotoxic therapy for an unrelated disorder, and there is absence + of the cytogenetic abnormalities that are present in acute myeloid leukemia + with recurrent genetic abnormalities. + termDef: + term: >- + Acute Myeloid Leukemia with Myelodysplasia-Related Changes + source: NCIt + cde_id: 'C7600 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7600 " + term_id: 'C7600 ' + term_version: 20.05a + +"98963": + common: + description: >- + An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 + fusion transcript and showing maturation in the neutrophil lineage. The bone + marrow and the peripheral blood show large myeloblasts with abundant basophilic + cytoplasm, often containing azurophilic granules. This type of AML is associated + with good response to chemotherapy and high complete remission rate. + termDef: + term: >- + Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 + source: NCIt + cde_id: C9288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9288" + term_id: C9288 + term_version: 20.05a + +"98973": + common: + description: >- + An acute myeloid leukemia associated with t(9;11)(p21.3;q23.3) and MLLT3-KMT2A + fusion protein expression. Morphologically it usually has monocytic features. + It may present at any age but it is more commonly seen in children. Patients + may present with disseminated intravascular coagulation. + termDef: + term: >- + Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A + source: NCIt + cde_id: C82403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82403" + term_id: C82403 + term_version: 20.05a + +"98981": + common: + description: >- + A myeloid proliferation occurring in newborns with Down syndrome. It is clinically + and morphologically indistinguishable from acute myeloid leukemia and is associated + with GATA1 mutations. The blasts display morphologic and immunophenotypic features + of megakaryocytic lineage. In the majority of patients the myeloid proliferation + undergoes spontaneous remission. + termDef: + term: >- + Transient Abnormal Myelopoiesis Associated with Down Syndrome + source: NCIt + cde_id: C82339 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82339" + term_id: C82339 + term_version: 20.05a + +"98983": + common: + description: >- + Acute myeloid leukemia or myelodysplastic syndrome occurring in children with + Down syndrome. The acute myeloid leukemia is usually an acute megakaryoblastic + leukemia, and is associated with GATA1 gene mutation. + termDef: + term: >- + Myeloid Leukemia Associated with Down Syndrome + source: NCIt + cde_id: C43223 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43223" + term_id: C43223 + term_version: 20.05a + +"99103": + common: + description: >- + An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic + lineage. (WHO, 2001) + termDef: + term: >- + Acute Megakaryoblastic Leukemia + source: NCIt + cde_id: C3170 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3170" + term_id: C3170 + term_version: 20.05a + +"99113": + common: + description: >- + An acute myeloid leukemia associated with t(1;22)(p13.3;q13.1) resulting in + the expression of RBM15-MKL1 fusion protein. It affects infants and children + and usually shows megakaryocytic maturation. + termDef: + term: >- + Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 + source: NCIt + cde_id: C82427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82427" + term_id: C82427 + term_version: 20.05a + +"99203": + common: + description: >- + Acute myeloid leukemias, myelodysplastic syndromes, and myelodysplastic/myeloproliferative + neoplasms arising as a result of the mutagenic effect of chemotherapy agents + and/or radiation that are used for the treatment of neoplastic or non-neoplastic + disorders. + termDef: + term: >- + Therapy-Related Myeloid Neoplasm + source: NCIt + cde_id: 'C27912 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27912 " + term_id: 'C27912 ' + term_version: 20.05a + +"99303": + common: + description: >- + A tumor mass composed of myeloblasts or immature myeloid cells. It occurs in + extramedullary sites or the bone. (WHO, 2001) + termDef: + term: >- + Myeloid Sarcoma + source: NCIt + cde_id: 'C3520 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3520 " + term_id: 'C3520 ' + term_version: 20.05a + +"99313": + common: + description: >- + An acute myeloid leukemia characterized by bone marrow fibrosis without preexisting + primary myelofibrosis. + termDef: + term: >- + Acute Panmyelosis with Myelofibrosis + source: NCIt + cde_id: C4344 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4344" + term_id: C4344 + term_version: 20.05a + +"99403": + common: + description: >- + A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, + and peripheral blood. Most patients present with splenomegaly and pancytopenia. + (WHO, 2001) + termDef: + term: >- + Hairy Cell Leukemia + source: NCIt + cde_id: 'C7402 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7402 " + term_id: 'C7402 ' + term_version: 20.05a + +"99453": + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent + monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer + than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence + of PDGFRA or PDGFRB rearrangement. + termDef: + term: >- + Chronic Myelomonocytic Leukemia + source: NCIt + cde_id: C3178 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3178" + term_id: C3178 + term_version: 20.05a + +"99463": + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm of childhood that is characterized + by proliferation principally of the granulocytic and monocytic lineages. Myelomonocytic + proliferation is seen in the bone marrow and the blood. The leukemic cells + may infiltrate any tissue, however liver, spleen, lymph nodes, skin, and respiratory + tract are the most common sites of involvement. (WHO, 2001) + termDef: + term: >- + Juvenile Myelomonocytic Leukemia + source: NCIt + cde_id: C9233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9233" + term_id: C9233 + term_version: 20.05a + +"99483": + common: + description: >- + A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known + as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart + of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers + and young adults. It is characterized by the systemic proliferation of NK cells + in the peripheral blood, bone marrow, liver, and spleen. + termDef: + term: >- + Aggressive NK-Cell Leukemia + source: NCIt + cde_id: C8647 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8647" + term_id: C8647 + term_version: 20.05a + +"99503": + common: + description: >- + A chronic myeloproliferative neoplasm characterized by an increased red blood + cell production. The bone marrow is hypercellular due to a panmyelotic proliferation + typically characterized by pleomorphic megakaryocytes. The major symptoms are + related to hypertension, splenomegaly or to episodes of thrombosis and/or hemorrhage. + termDef: + term: >- + Polycythemia Vera + source: NCIt + cde_id: C3336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3336" + term_id: C3336 + term_version: 20.05a + +"99603": + common: + description: >- + A clonal hematopoietic stem cell disorder, characterized by proliferation in + the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, + megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. + (WHO 2008) + termDef: + term: >- + Myeloproliferative Neoplasm + source: NCIt + cde_id: C4345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4345" + term_id: C4345 + term_version: 20.05a + +"99613": + common: + description: >- + A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, + proliferation of atypical megakaryocytes and granulocytes in the bone marrow, + anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001) + termDef: + term: >- + Primary Myelofibrosis + source: NCIt + cde_id: C2862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2862" + term_id: C2862 + term_version: 20.05a + +"99623": + common: + description: >- + A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic + lineage. It is characterized by sustained thrombocytosis in the blood, increased + numbers of large, mature megakaryocytes in the bone marrow, and episodes of + thrombosis and/or hemorrhage. (WHO, 2008) + termDef: + term: >- + Essential Thrombocythemia + source: NCIt + cde_id: C3407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3407" + term_id: C3407 + term_version: 20.05a + +"99633": + common: + description: >- + A rare chronic myeloproliferative neoplasm characterized by neutrophilic leukocytosis. There + is no detectable Philadelphia chromosome or BCR/ABL fusion gene. + termDef: + term: >- + Chronic Neutrophilic Leukemia + source: NCIt + cde_id: C3179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3179" + term_id: C3179 + term_version: 20.05a + +"99643": + common: + description: >- + A rare myeloproliferative neoplasm characterized by a clonal proliferation of + eosinophilic precursors resulting in persistently increased numbers of eosinophils + in the blood, marrow and peripheral tissues. Since acute eosinophilic leukemia + is at best exceedingly rare, the term eosinophilic leukemia is normally used + as a synonym for chronic eosinophilic leukemia. In cases in which it is impossible + to prove clonality and there is no increase in blast cells, the diagnosis of + "idiopathic hypereosinophilic syndrome" is preferred. (WHO, 2001) + termDef: + term: >- + Chronic Eosinophilic Leukemia, Not Otherwise Specified + source: NCIt + cde_id: 'C4563 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4563 " + term_id: 'C4563 ' + term_version: 20.05a + +"99653": + common: + description: >- + Hematologic neoplasms characterized by the rearrangement of the PDGFRA gene, + most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts. Patients + usually present with chronic eosinophilic leukemia, and less often with acute + myeloid leukemia or T-lymphoblastic leukemia. + termDef: + term: >- + Myeloid/Lymphoid Neoplasms with PDGFRA Rearrangement + source: NCIt + cde_id: C84275 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84275" + term_id: C84275 + term_version: 20.05a + +"99663": + common: + description: >- + Myeloid and rarely lymphoid neoplasms characterized by the rearrangement of + the PDGFRB gene, most often resulting in the formation of ETV6-PDGFRB fusion + transcripts. Patients usually present with chronic myelomonocytic leukemia and + less often with atypical chronic myeloid leukemia, or chronic eosinophilic leukemia. + termDef: + term: >- + Myeloid/Lymphoid Neoplasms with PDGFRB Rearrangement + source: NCIt + cde_id: C84276 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84276" + term_id: C84276 + term_version: 20.05a + +"99701": + common: + description: >- + A disorder characterized by proliferation of lymphocytes at various stages of + differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as + in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis). + termDef: + term: >- + Lymphoproliferative Disorder + source: NCIt + cde_id: C9308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9308" + term_id: C9308 + term_version: 20.05a + +"99711": + common: + description: >- + Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) + or clonal (malignant) proliferation of lymphoid cells that develops as a consequence + of immunosuppression in a recipient of a solid organ or bone marrow allograft. + PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven + polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas + of predominantly B-cell or less often T-cell type. (WHO, 2001) + termDef: + term: >- + Post-Transplant Lymphoproliferative Disorder + source: NCIt + cde_id: C4727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4727" + term_id: C4727 + term_version: 20.05a + +"99713": + common: + description: >- + A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant + immunosuppression therapy. It is characterized by destructive infiltration of + lymph nodes and extranodal sites by a polymorphic B-cell infiltrate composed + of small and medium sized lymphocytes, immunoblasts, and plasma cells. In some + cases, reduction of the immunosuppression therapy may lead to regression of + the lesions. In other cases the lesions may progress to lymphoma. + termDef: + term: >- + Polymorphic Post-Transplant Lymphoproliferative Disorder + source: NCIt + cde_id: C7183 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7183" + term_id: C7183 + term_version: 20.05a + +"99753": + common: + description: >- + This entity includes cases that have clinical, laboratory, and morphologic features + that support the diagnosis of both a myelodysplastic syndrome and a myeloproliferative + neoplasm, but do not meet the criteria for any of the other entities included + in the myelodysplastic/myeloproliferative neoplasm category. (WHO, 2001) + termDef: + term: >- + Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable + source: NCIt + cde_id: C27780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27780" + term_id: C27780 + term_version: 20.05a + +"99803": + common: + description: >- + A myelodysplastic syndrome characterized mainly by dysplasia of the erythroid + series. Refractory anemia is uncommon. It is primarily a disease of older + adults. The median survival exceeds 5 years. (WHO, 2001) + termDef: + term: >- + Refractory Anemia + source: NCIt + cde_id: C2872 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2872" + term_id: C2872 + term_version: 20.05a + +"99823": + common: + description: >- + A myelodysplastic syndrome characterized by an anemia in which 15% or more of + the erythroid precursors are ring sideroblasts. The ring sideroblast is an + erythroid precursor in which one third or more of the nucleus is encircled by + granules which are positive for iron stain. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Ring Sideroblasts + source: NCIt + cde_id: 'C4036 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4036 " + term_id: 'C4036 ' + term_version: 20.05a + +"99833": + common: + description: >- + A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts + in the bone marrow or 2-19% blasts in the peripheral blood. It includes two + categories: myelodysplastic syndrome with excess blasts-1 and myelodysplastic + syndrome with excess blasts-2. + termDef: + term: >- + Myelodysplastic Syndrome with Excess Blasts + source: NCIt + cde_id: C7506 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7506" + term_id: C7506 + term_version: 20.05a + +"99843": + common: + description: >- + Refractory anemia with excess blasts in transformation (RAEB-T) is characterised + by dysplastic features of the myeloid and usually erythroid progenitor cells + in the bone marrow and an increased number of myeloblasts in the peripheral + blood. The peripheral blood blast count ranges from 20% to 30%. RAEB-T used + to be a subcategory of myelodysplastic syndromes in the past. Recently, the + term has been eliminated from the WHO based classification of myelodysplastic + syndromes. The reason is that the percentage of peripheral blood blasts required + for the diagnosis of acute myeloid leukemia has been reduced to 20%. The elimination + of the RAEB-T term by the WHO experts has created confusion and ongoing arguments. Currently, + according to WHO classification, the vast majority of RAEB-T cases are best + classified as acute leukemias (acute leukemias with multilineage dysplasia following + myelodysplastic syndrome). A minority of cases are part of RAEB-2. + termDef: + term: >- + Refractory Anemia with Excess Blasts in Transformation + source: NCIt + cde_id: C27080 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27080" + term_id: C27080 + term_version: 20.05a + +"99853": + common: + description: >- + A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia and + dysplastic changes in 10% or more of the cells in two or more of the myeloid + cell lines. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Multilineage Dysplasia + source: NCIt + cde_id: 'C8574 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8574 " + term_id: 'C8574 ' + term_version: 20.05a + +"99863": + common: + description: >- + A myelodysplastic syndrome characterized by a deletion between bands q31 and + 33 on chromosome 5. The number of blasts in the bone marrow and blood is <5%. The + bone marrow is usually hypercellular or normocellular with increased number + of often hypolobated megakaryocytes. The peripheral blood shows macrocytic + anemia. This syndrome occurs predominantly but not exclusively in middle age + to older women. The prognosis is good and transformation to acute leukemia + is rare. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Isolated del(5q) + source: NCIt + cde_id: C6867 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6867" + term_id: C6867 + term_version: 20.05a + +"99873": + common: + description: >- + A myelodysplastic syndrome caused by chemotherapy and/or radiotherapy. + termDef: + term: >- + Therapy-Related Myelodysplastic Syndrome + source: NCIt + cde_id: 'C27722 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27722 " + term_id: 'C27722 ' + term_version: 20.05a + +"99893": + common: + description: >- + A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis + in one or more of the hematopoietic cell lines. The dysplasia may be accompanied + by an increase in myeloblasts, but the number is less than 20%, which, according + to the WHO guidelines, is the requisite threshold for the diagnosis of acute + myeloid leukemia. It may occur de novo or as a result of exposure to alkylating + agents and/or radiotherapy. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome + source: NCIt + cde_id: 'C3247 ' + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3247 " + term_id: 'C3247 ' + term_version: 20.05a + +"99913": + common: + description: >- + A myelodysplastic syndrome characterized by the presence of at least 10% dysplastic + neutrophils in the bone marrow or the peripheral blood. + termDef: + term: >- + Refractory Neutropenia + source: NCIt + cde_id: C82593 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82593" + term_id: C82593 + term_version: 20.05a + +"99923": + common: + description: >- + A myelodysplastic syndrome characterized by the presence of at least 10% dysplastic + megakaryocytes, found within at least 30 megakaryocytes examined in the bone + marrow. + termDef: + term: >- + Refractory Thrombocytopenia + source: NCIt + cde_id: C82594 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82594" + term_id: C82594 + term_version: 20.05a + +0__no_fibrosis: + common: + description: >- + No evidence of fibrosis. + termDef: + term: >- + Ishak Score 0 + source: NCIt + cde_id: C95150 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95150" + term_id: C95150 + term_version: 20.05a + +12__portal_fibrosis: + common: + description: >- + Portal fibrosis is present. + termDef: + term: >- + Ishak Score 1-2 + source: NCIt + cde_id: C157159 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157159" + term_id: C157159 + term_version: 20.05a + +3_prime_utr_variant: + common: + description: >- + Any mutation in a gene occurring in the 3' end which contains sequences which + may regulate the transcription or translation of the message. 3' UTR mutations + are found only outside of open reading frames. + termDef: + term: >- + 3' Untranslated Region Mutation + source: NCIt + cde_id: C63433 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63433" + term_id: C63433 + term_version: 20.10d + +3160_minutes: + common: + description: >- + An indication that between 31 and 60 minutes passes between waking and smoking + the first cigarette of the day. + termDef: + term: >- + Time Between Waking and First Smoke - Between 31 and 60 Minutes + source: NCIt + cde_id: C164126 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164126" + term_id: C164126 + term_version: 19.12e + +34__fibrous_septa: + common: + description: >- + Fibrosis extends beyond the portal areas and bridging fibrosis is present. + termDef: + term: >- + Ishak Score 3-4 + source: NCIt + cde_id: C157161 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157161" + term_id: C157161 + term_version: 20.05a + +3da_phosphoramidate_nuc7738: + common: + description: >- + A phosphoramidate derivative of the monophosphate form of cordycepin (3'-deoxyadenosine; + 3'-dA), an adenosine derivative first isolated from Cordyceps sinensis, with + potential antineoplastic, antioxidant, and anti-inflammatory activities. Upon + administration and cellular uptake of NUC-7738 by passive diffusion, cordycepin + monophosphate (3'-dAMP) is converted into its active anti-cancer metabolite + 3'-deoxyadenosine triphosphate (3'-dATP). 3'-dATP functions as a ribonucleoside + analogue and competes with ATP during transcription. Therefore, this agent causes + RNA synthesis inhibition, inhibits cellular proliferation, and induces apoptosis. + Also, 3'-dAMP activates AMP-activated protein kinase (AMPK) and reduces mammalian + target of rapamycin (mTOR) signaling. This prevents the hyperphosphorylation + of the translation repressor protein 4E-BP1. This results in the induction of + tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine + kinase belonging to the phosphatidylinositol 3-kinase (PI3K)-related kinase + (PIKK) family, plays an important role in the PI3K/AKT/mTOR signaling pathway + that regulates cell growth and proliferation, and its expression or activity + is frequently dysregulated in human cancers. Compared to cordycepin alone, the + addition of the phosphoramidate moiety may overcome cancer resistance and allow + for greater cytotoxicity as NUC-7738 does not require a nucleoside transporter + for cellular uptake, is independent of enzymatic activation by adenosine kinase + (AK) and is not susceptible to enzymatic degradation by adenosine deaminase + (ADA). Altogether, this may help overcome cancer resistance to cordycepin. + termDef: + term: >- + 3'-dA Phosphoramidate NUC-7738 + source: NCIt + cde_id: C171381 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171381" + term_id: C171381 + term_version: 20.10d + +4_or_more: + common: + description: >- + An indication that cancer cells have been detected in four or more lymph nodes. + termDef: + term: >- + Four or More Positive Lymph Nodes + source: NCIt + cde_id: C172226 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172226" + term_id: C172226 + term_version: 20.10d + +5__nodular_formation_and_incomplete_cirrhosis: + common: + description: >- + Marked bridging fibrosis with formation of occasional hepatic nodules is present. + termDef: + term: >- + Ishak Score 5 + source: NCIt + cde_id: C95155 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95155" + term_id: C95155 + term_version: 20.05a + +5_prime_utr_variant: + common: + description: >- + Any mutation in a gene occurring in the 5' end which contains sequences which + may regulate the transcription or translation of the message. 5' UTR mutations + are found only outside of open-reading frames. + termDef: + term: >- + 5' Untranslated Region Mutation + source: NCIt + cde_id: C63432 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63432" + term_id: C63432 + term_version: 20.10d + +5hydroxyindoleacetic_acid: + common: + description: >- + The determination of the amount of 5-hydroxyindoleacetic acid present in a sample. + termDef: + term: >- + 5-Hydroxyindoleacetic Acid Measurement + source: NCIt + cde_id: C112217 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112217" + term_id: C112217 + term_version: 20.10d + +6__established_cirrhosis: + common: + description: >- + Marked fibrosis with cirrhosis is present. + termDef: + term: >- + Ishak Score 6 + source: NCIt + cde_id: C95156 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95156" + term_id: C95156 + term_version: 20.05a + +630_minutes: + common: + description: >- + An indication that between 6 and 30 minutes passes between waking and smoking + the first cigarette of the day. + termDef: + term: >- + Time Between Waking and First Smoke - Between 6 and 30 Minutes + source: NCIt + cde_id: C164124 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164124" + term_id: C164124 + term_version: 19.12e + +6th: + common: + description: >- + A cancer stage defined according to the AJCC 6th edition criteria. + termDef: + term: >- + AJCC v6 Stage + source: NCIt + cde_id: C90529 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C90529" + term_id: C90529 + term_version: 20.05a + +7th: + common: + description: >- + A cancer stage defined according to the AJCC 7th edition criteria. + termDef: + term: >- + AJCC v7 Stage + source: NCIt + cde_id: C90530 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C90530" + term_id: C90530 + term_version: 20.05a + +8th: + common: + description: >- + A cancer stage defined according to the AJCC 8th edition criteria. + termDef: + term: >- + AJCC v8 Stage + source: NCIt + cde_id: C132248 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132248" + term_id: C132248 + term_version: 20.05a + +a: + common: + description: >- + Child-Pugh score indicating one-year survival of 100% in patients with chronic + liver disease and cirrhosis. This score is determined by the study of the following + five factors: bilirubin, albumin, international normalized ratio, presence and + degree of ascites, and presence and degree of encephalopathy. + termDef: + term: >- + Child-Pugh Class A + source: NCIt + cde_id: C113691 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113691" + term_id: C113691 + term_version: 20.05a + +a1cf: + common: + description: >- + This gene is involved in the deamination of APOB mRNA. + termDef: + term: >- + A1CF Gene + source: NCIt + cde_id: C143031 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143031" + term_id: C143031 + term_version: 20.10d + +a2a_receptor_antagonist_eos100850: + common: + description: >- + An orally bioavailable immune checkpoint inhibitor and antagonist of the adenosine + A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic + activities. Upon administration, A2AR antagonist EOS100850 selectively binds + to and inhibits A2AR expressed on T-lymphocytes. This prevents tumor-released + adenosine from interacting with the A2A receptors, thereby blocking the adenosine/A2AR-mediated + inhibition of T-lymphocytes. This results in the proliferation and activation + of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor + cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces + of T-cells and, upon activation by adenosine, inhibits their proliferation and + activation. Adenosine is often overproduced by cancer cells and plays a key + role in immunosuppression. + termDef: + term: >- + A2A Receptor Antagonist EOS100850 + source: NCIt + cde_id: C172109 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172109" + term_id: C172109 + term_version: 20.10d + +a5: + common: + description: >- + A total score of 5 for hepatic function, corresponding to class A in the Child-Pugh + classification. + termDef: + term: >- + Child-Pugh Class A5 + source: NCIt + cde_id: C146790 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146790" + term_id: C146790 + term_version: 20.05a + +a6: + common: + description: >- + A total score of 6 for hepatic function, corresponding to class A in the Child-Pugh + classification. + termDef: + term: >- + Child-Pugh Class A6 + source: NCIt + cde_id: C146791 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146791" + term_id: C146791 + term_version: 20.05a + +abdomen: + common: + description: >- + The portion of the body that lies between the thorax and the pelvis. + termDef: + term: >- + Abdomen + source: NCIt + cde_id: C12664 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12664" + term_id: C12664 + term_version: 20.05a + +abdomen_nos: + common: + description: >- + The portion of the body that lies between the thorax and the pelvis. + termDef: + term: >- + Abdomen + source: NCIt + cde_id: C12664 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12664" + term_id: C12664 + term_version: 20.05a + +abdominal_desmoid: + common: + description: >- + An insidious poorly circumscribed neoplasm arising from the deep soft tissues + of the abdomen. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + termDef: + term: >- + Abdominal (Mesenteric) Fibromatosis + source: NCIt + cde_id: C3741 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3741" + term_id: C3741 + term_version: 20.05a + +abdominal_esophagus: + common: + description: >- + Clinical esophageal segment composed of smooth muscle. It corresponds to the + inferior part of the lower third topographic segment of the esophagus. + termDef: + term: >- + Abdominal Esophagus + source: NCIt + cde_id: C12252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12252" + term_id: C12252 + term_version: 20.05a + +abdominal_fibromatosis: + common: + description: >- + An insidious poorly circumscribed neoplasm arising from the deep soft tissues + of the abdomen. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + termDef: + term: >- + Abdominal (Mesenteric) Fibromatosis + source: NCIt + cde_id: C3741 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3741" + term_id: C3741 + term_version: 20.05a + +abdominal_peritoneum: + common: + description: >- + A membranous lining of the abdominal cavity and abdominal organs. + termDef: + term: >- + Abdominal Peritoneum + source: NCIt + cde_id: C159355 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C159355" + term_id: C159355 + term_version: 20.05a + +abi1: + common: + description: >- + This gene plays a role in signal transduction and negative regulation of cell + proliferation. + termDef: + term: >- + ABI1 Gene + source: NCIt + cde_id: C24824 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24824" + term_id: C24824 + term_version: 20.10d + +abl1: + common: + description: >- + This gene is involved in cell adhesion, differentiation, division and stress + response. + termDef: + term: >- + ABL1 Gene + source: NCIt + cde_id: C17346 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17346" + term_id: C17346 + term_version: 20.10d + +abl2: + common: + description: >- + This gene plays a role in signal transduction. + termDef: + term: >- + ABL2 Gene + source: NCIt + cde_id: C18451 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18451" + term_id: C18451 + term_version: 20.10d + +abnormal_nos: + common: + description: >- + A laboratory test result that falls outside of the normal, acceptable range. + termDef: + term: >- + Abnormal Laboratory Test Result + source: NCIt + cde_id: C26683 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26683" + term_id: C26683 + term_version: 20.10d + +absent: + common: + description: >- + Not existing in a specified place at a specified time. + termDef: + term: >- + Absent + source: NCIt + cde_id: C48190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48190" + term_id: C48190 + term_version: 20.05a + pathology_detail: + transglottic_extension: + description: >- + A finding of normality following an examination or investigation looking for + the presence of a microorganism, disease, or condition. + termDef: + term: >- + Negative Finding + source: NCIt + cde_id: C38757 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38757" + term_id: C38757 + term_version: 20.05a + +absolute_neutrophil: + common: + description: >- + The real number of white blood cells (WBC) that are neutrophils. It is derived + by multiplying the WBC count by the percent of neutrophils in the differential + WBC count. The normal range for ANC is 1.5 to 8.0 (1,500 to 8,000/mm3). + termDef: + term: >- + Absolute Neutrophil Count + source: NCIt + cde_id: C63321 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63321" + term_id: C63321 + term_version: 20.10d + +accessory_sinus_nos: + common: + description: >- + Any one of the air-filled spaces within the ethmoid, frontal, maxillary, or + sphenoid bones, which communicate with the nasal cavity. + termDef: + term: >- + Paranasal Sinus + source: NCIt + cde_id: C12763 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12763" + term_id: C12763 + term_version: 20.05a + +accidental_building_fire_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + during a building fire that was not caused by deliberate human actions. + termDef: + term: >- + Accidental Building Fire Smoke Exposure + source: NCIt + cde_id: C164066 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164066" + term_id: C164066 + term_version: 19.12e + +accidental_fire_smoke_grass: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + during a grass fire that was not caused by deliberate human actions. + termDef: + term: >- + Accidental Grass Fire Smoke Exposure + source: NCIt + cde_id: C164067 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164067" + term_id: C164067 + term_version: 19.12e + +accidental_fire_smoke_nos: + common: + description: >- + Environmental exposure to airborne gases and particulates produced during a + fire that was not caused by deliberate human actions. + termDef: + term: >- + Accidental Fire Smoke Exposure + source: NCIt + cde_id: C164059 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164059" + term_id: C164059 + term_version: 19.12e + +accidental_forest_fire_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + during a forest fire that was not caused by deliberate human actions. + termDef: + term: >- + Accidental Forest Fire Smoke Exposure + source: NCIt + cde_id: C164068 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164068" + term_id: C164068 + term_version: 19.12e + +accidental_vehicle_fire_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + during a vehicle fire that was not caused by deliberate human actions. + termDef: + term: >- + Accidental Vehicle Fire Smoke Exposure + source: NCIt + cde_id: C164069 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164069" + term_id: C164069 + term_version: 19.12e + +achromic_nevus: + common: + description: >- + A benign nevus characterized by the absence of melanin pigment in the melanocytes. + termDef: + term: >- + Nonpigmented Nevus + source: NCIt + cde_id: C27095 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27095" + term_id: C27095 + term_version: 20.05a + +acidophil_adenocarcinoma: + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with acidic dyes. + termDef: + term: >- + Pituitary Gland Acidophil Carcinoma + source: NCIt + cde_id: C4147 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4147" + term_id: C4147 + term_version: 20.05a + +acidophil_adenoma: + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells stain positive with acidic dyes. + termDef: + term: >- + Pituitary Gland Acidophil Adenoma + source: NCIt + cde_id: C6780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6780" + term_id: C6780 + term_version: 20.05a + +acidophil_carcinoma: + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with acidic dyes. + termDef: + term: >- + Pituitary Gland Acidophil Carcinoma + source: NCIt + cde_id: C4147 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4147" + term_id: C4147 + term_version: 20.05a + +acinar_adenocarcinoma: + common: + description: >- + A malignant glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. Representative examples include the acinar cell carcinoma of + the pancreas and the acinar adenocarcinoma of the prostate gland. + termDef: + term: >- + Acinar Cell Carcinoma + source: NCIt + cde_id: C3768 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3768" + term_id: C3768 + term_version: 20.05a + +acinar_adenocarcinoma_sarcomatoid: + common: + description: >- + A rare morphologic variant of acinar adenocarcinoma of the prostate gland with + unfavorable prognosis, composed of both malignant glandular and sarcomatous + components. The sarcomatous component contains a malignant spindle cell proliferation + or specific mesenchymal elements including osteosarcoma, chondrosarcoma, and + leiomyosarcoma. + termDef: + term: >- + Prostate Acinar Adenocarcinoma, Sarcomatoid Variant + source: NCIt + cde_id: C5530 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5530" + term_id: C5530 + term_version: 20.05a + +acinar_adenoma: + common: + description: >- + A benign glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. + termDef: + term: >- + Acinar Cell Adenoma + source: NCIt + cde_id: C4196 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4196" + term_id: C4196 + term_version: 20.05a + +acinar_carcinoma: + common: + description: >- + A malignant glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. Representative examples include the acinar cell carcinoma of + the pancreas and the acinar adenocarcinoma of the prostate gland. + termDef: + term: >- + Acinar Cell Carcinoma + source: NCIt + cde_id: C3768 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3768" + term_id: C3768 + term_version: 20.05a + +acinar_cell_adenoma: + common: + description: >- + A benign glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. + termDef: + term: >- + Acinar Cell Adenoma + source: NCIt + cde_id: C4196 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4196" + term_id: C4196 + term_version: 20.05a + +acinar_cell_carcinoma: + common: + description: >- + A malignant glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. Representative examples include the acinar cell carcinoma of + the pancreas and the acinar adenocarcinoma of the prostate gland. + termDef: + term: >- + Acinar Cell Carcinoma + source: NCIt + cde_id: C3768 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3768" + term_id: C3768 + term_version: 20.05a + +acinar_cell_cystadenocarcinoma: + common: + description: >- + A cystic adenocarcinoma characterized by the presence of relatively uniform + neoplastic cells which produce pancreatic enzymes and are arranged in acinar + patterns. Signs and symptoms include abdominal pain, weight loss, nausea, and + diarrhea. It usually has an aggressive clinical course. + termDef: + term: >- + Pancreatic Acinar Cell Cystadenocarcinoma + source: NCIt + cde_id: C5727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5727" + term_id: C5727 + term_version: 20.05a + +acinar_cell_tumor: + common: + description: >- + A benign or malignant glandular epithelial neoplasm consisting of secretory + cells forming acinar patterns. It includes the acinar cell adenoma and acinar + cell carcinoma. + termDef: + term: >- + Acinar Cell Neoplasm + source: NCIt + cde_id: C4197 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4197" + term_id: C4197 + term_version: 20.05a + +acinic_cell_adenocarcinoma: + common: + description: >- + A malignant glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. Representative examples include the acinar cell carcinoma of + the pancreas and the acinar adenocarcinoma of the prostate gland. + termDef: + term: >- + Acinar Cell Carcinoma + source: NCIt + cde_id: C3768 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3768" + term_id: C3768 + term_version: 20.05a + +acinic_cell_adenoma: + common: + description: >- + A benign glandular epithelial neoplasm consisting of secretory cells forming + acinar patterns. + termDef: + term: >- + Acinar Cell Adenoma + source: NCIt + cde_id: C4196 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4196" + term_id: C4196 + term_version: 20.05a + +acinic_cell_tumor: + common: + description: >- + A benign or malignant glandular epithelial neoplasm consisting of secretory + cells forming acinar patterns. It includes the acinar cell adenoma and acinar + cell carcinoma. + termDef: + term: >- + Acinar Cell Neoplasm + source: NCIt + cde_id: C4197 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4197" + term_id: C4197 + term_version: 20.05a + +ackr3: + common: + description: >- + This gene is involved in the regulation of chemokine signaling. + termDef: + term: >- + ACKR3 Gene + source: NCIt + cde_id: C91369 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C91369" + term_id: C91369 + term_version: 20.10d + +acoustic_nerve: + common: + description: >- + The cochlear portion of cranial nerve VIII (the vestibulocochlear nerve), which + transmits auditory sensory impulses to the cochlear nucleus in the brainstem. + termDef: + term: >- + Cochlear Nerve + source: NCIt + cde_id: C12697 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12697" + term_id: C12697 + term_version: 20.05a + +acoustic_neuroma: + common: + description: >- + A type of benign brain tumor that begins in the Schwann cells, which produce + the myelin that protects the acoustic nerve - the nerve of hearing. + termDef: + term: >- + Acoustic Schwannoma + source: NCIt + cde_id: C3276 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3276" + term_id: C3276 + term_version: 20.05a + +acquired_cystic_diseaseassociated_renal_cell_carcinoma_rcc: + common: + description: >- + The most common renal cell carcinoma that develops in patients with end-stage + renal disease and acquired cystic disease. + termDef: + term: >- + Acquired Cystic Disease-Associated Renal Cell Carcinoma + source: NCIt + cde_id: C157718 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157718" + term_id: C157718 + term_version: 20.05a + +acral_lentiginous_melanoma_malignant: + common: + description: >- + A form of melanoma occurring most often on the plantar, palmar, subungual, and + periungual skin. It presents as a pigmented macular lesion with irregular borders. Morphologically, + it consists of atypical spindled and dendritic melanocytes. The epidermis is + often hyperplastic and there is pagetoid infiltration of the epidermis by anaplastic + cells. + termDef: + term: >- + Acral Lentiginous Melanoma + source: NCIt + cde_id: C4022 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4022" + term_id: C4022 + term_version: 20.05a + +acsl3: + common: + description: >- + This gene is involved in lipid biosynthesis. + termDef: + term: >- + ACSL3 Gene + source: NCIt + cde_id: C97365 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97365" + term_id: C97365 + term_version: 20.10d + +acsl6: + common: + description: >- + This gene is involved in the biosynthesis of lipids. + termDef: + term: >- + ACSL6 Gene + source: NCIt + cde_id: C97519 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97519" + term_id: C97519 + term_version: 20.10d + +acute_basophilic_leukaemia: + common: + description: >- + A rare acute myeloid leukemia in which the immature cells differentiate towards + basophils. + termDef: + term: >- + Acute Basophilic Leukemia + source: NCIt + cde_id: C3164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3164" + term_id: C3164 + term_version: 20.05a + +acute_bilineal_leukemia: + common: + description: >- + An acute leukemia of ambiguous lineage in which there is a dual population of + blasts with each population expressing markers of a distinct lineage (myeloid + and lymphoid or B-and T-lymphocyte). (WHO, 2001) + termDef: + term: >- + Acute Bilineal Leukemia + source: NCIt + cde_id: C6923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6923" + term_id: C6923 + term_version: 20.05a + +acute_biphenotypic_leukemia: + common: + description: >- + An acute leukemia of ambiguous lineage characterized by blasts which coexpress + myeloid and T or B lineage antigens or concurrent B and T lineage antigens. (WHO, + 2001) + termDef: + term: >- + Acute Biphenotypic Leukemia + source: NCIt + cde_id: C4673 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4673" + term_id: C4673 + term_version: 20.05a + +acute_erythremia: + common: + description: >- + An acute myeloid leukemia characterized by a predominant immature erythroid + population. There are two subtypes recognized: erythroleukemia and pure erythroid + leukemia. (WHO, 2001) + termDef: + term: >- + Acute Erythroid Leukemia + source: NCIt + cde_id: C8923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8923" + term_id: C8923 + term_version: 20.05a + +acute_erythremic_myelosis: + common: + description: >- + Acute erythroid leukemia characterised by the presence of immature erythroid + cells in the bone marrow (at least 80% of the cellular component), without evidence + of a significant myeloblastic cell population present. + termDef: + term: >- + Pure Erythroid Leukemia + source: NCIt + cde_id: C7467 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7467" + term_id: C7467 + term_version: 20.05a + +acute_erythroid_leukaemia: + common: + description: >- + An acute myeloid leukemia characterized by a predominant immature erythroid + population. There are two subtypes recognized: erythroleukemia and pure erythroid + leukemia. (WHO, 2001) + termDef: + term: >- + Acute Erythroid Leukemia + source: NCIt + cde_id: C8923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8923" + term_id: C8923 + term_version: 20.05a + +acute_granulocytic_leukemia: + common: + description: >- + A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. + The classification of acute myeloid leukemias (AMLs) encompasses four major + categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage + dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required + bone marrow or peripheral blood blast percentage for the diagnosis of AML is + 20% (WHO classification). + termDef: + term: >- + Acute Myeloid Leukemia + source: NCIt + cde_id: C3171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3171" + term_id: C3171 + term_version: 20.05a + +acute_leukemia_burkitt_type: + common: + description: >- + The leukemic counterpart of Burkitt's lymphoma. The characteristic Burkitt cells + are seen in the bone marrow and the peripheral blood. This is an aggressive + leukemia. + termDef: + term: >- + Burkitt Leukemia + source: NCIt + cde_id: C7400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7400" + term_id: C7400 + term_version: 20.05a + +acute_leukemia_nos: + common: + description: >- + A rare acute leukemia of ambiguous lineage in which the blasts do not express + markers specific to myeloid or lymphoid lineage. + termDef: + term: >- + Acute Undifferentiated Leukemia + source: NCIt + cde_id: C9298 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9298" + term_id: C9298 + term_version: 20.05a + +acute_lymphatic_leukemia: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +acute_lymphoblastic_leukemia_l2_type_nos: + common: + description: >- + An antiquated term that refers to acute lymphoblastic leukemia with large and + irregular lymphoblasts. + termDef: + term: >- + L2 Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27281 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27281" + term_id: C27281 + term_version: 20.05a + +acute_lymphoblastic_leukemia_mature_bcell_type: + common: + description: >- + The leukemic counterpart of Burkitt's lymphoma. The characteristic Burkitt cells + are seen in the bone marrow and the peripheral blood. This is an aggressive + leukemia. + termDef: + term: >- + Burkitt Leukemia + source: NCIt + cde_id: C7400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7400" + term_id: C7400 + term_version: 20.05a + +acute_lymphoblastic_leukemia_nos: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +acute_lymphoblastic_leukemia_precursor_cell_type: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +acute_lymphoblastic_leukemialymphoma_nos: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +acute_lymphocytic_leukemia: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +acute_lymphoid_leukemia: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +acute_megakaryoblastic_leukaemia: + common: + description: >- + An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic + lineage. (WHO, 2001) + termDef: + term: >- + Acute Megakaryoblastic Leukemia + source: NCIt + cde_id: C3170 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3170" + term_id: C3170 + term_version: 20.05a + +acute_mixed_lineage_leukemia: + common: + description: >- + An acute leukemia of ambiguous lineage in which there is a dual population of + blasts with each population expressing markers of a distinct lineage (myeloid + and lymphoid or B-and T-lymphocyte). (WHO, 2001) + termDef: + term: >- + Acute Bilineal Leukemia + source: NCIt + cde_id: C6923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6923" + term_id: C6923 + term_version: 20.05a + +acute_monoblastic_and_monocytic_leukemia: + common: + description: >- + Acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic + lineage, including monoblasts, promonocytes, and monocytes. Bleeding disorders + are common presenting features. + termDef: + term: >- + Acute Monoblastic and Monocytic Leukemia + source: NCIt + cde_id: C7318 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7318" + term_id: C7318 + term_version: 20.05a + +acute_monoblastic_leukemia: + common: + description: >- + An acute myeloid leukemia in which the monoblasts represent 80% or more of the + total cellular population. (WHO, 2001) + termDef: + term: >- + Acute Monoblastic Leukemia + source: NCIt + cde_id: C7171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7171" + term_id: C7171 + term_version: 20.05a + +acute_monocytic_leukemia: + common: + description: >- + An acute myeloid leukemia in which the majority of monocytic cells are promonocytes. (WHO, + 2001) + termDef: + term: >- + Acute Monocytic Leukemia + source: NCIt + cde_id: C4861 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4861" + term_id: C4861 + term_version: 20.05a + +acute_myeloblastic_leukemia: + common: + description: >- + A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. + The classification of acute myeloid leukemias (AMLs) encompasses four major + categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage + dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required + bone marrow or peripheral blood blast percentage for the diagnosis of AML is + 20% (WHO classification). + termDef: + term: >- + Acute Myeloid Leukemia + source: NCIt + cde_id: C3171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3171" + term_id: C3171 + term_version: 20.05a + +acute_myelocytic_leukemia: + common: + description: >- + A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. + The classification of acute myeloid leukemias (AMLs) encompasses four major + categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage + dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required + bone marrow or peripheral blood blast percentage for the diagnosis of AML is + 20% (WHO classification). + termDef: + term: >- + Acute Myeloid Leukemia + source: NCIt + cde_id: C3171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3171" + term_id: C3171 + term_version: 20.05a + +acute_myelofibrosis: + common: + description: >- + An acute myeloid leukemia characterized by bone marrow fibrosis without preexisting + primary myelofibrosis. + termDef: + term: >- + Acute Panmyelosis with Myelofibrosis + source: NCIt + cde_id: C4344 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4344" + term_id: C4344 + term_version: 20.05a + +acute_myelogenous_leukemia: + common: + description: >- + A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. + The classification of acute myeloid leukemias (AMLs) encompasses four major + categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage + dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required + bone marrow or peripheral blood blast percentage for the diagnosis of AML is + 20% (WHO classification). + termDef: + term: >- + Acute Myeloid Leukemia + source: NCIt + cde_id: C3171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3171" + term_id: C3171 + term_version: 20.05a + +acute_myeloid_leukaemia_t821q22q22: + common: + description: >- + An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 + fusion transcript and showing maturation in the neutrophil lineage. The bone + marrow and the peripheral blood show large myeloblasts with abundant basophilic + cytoplasm, often containing azurophilic granules. This type of AML is associated + with good response to chemotherapy and high complete remission rate. + termDef: + term: >- + Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 + source: NCIt + cde_id: C9288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9288" + term_id: C9288 + term_version: 20.05a + +acute_myeloid_leukemia_aml1cbfalphaeto: + common: + description: >- + An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 + fusion transcript and showing maturation in the neutrophil lineage. The bone + marrow and the peripheral blood show large myeloblasts with abundant basophilic + cytoplasm, often containing azurophilic granules. This type of AML is associated + with good response to chemotherapy and high complete remission rate. + termDef: + term: >- + Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 + source: NCIt + cde_id: C9288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9288" + term_id: C9288 + term_version: 20.05a + +acute_myeloid_leukemia_cbfbetamyh11: + common: + description: >- + An acute myeloid leukemia with monocytic and granulocytic differentiation and + the presence of a characteristically abnormal eosinophil component in the bone + marrow. This type of acute myeloid leukemia has a favorable prognosis. (WHO, + 2001) + termDef: + term: >- + Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 + source: NCIt + cde_id: C9287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9287" + term_id: C9287 + term_version: 20.05a + +acute_myeloid_leukemia_inv16p13q22: + common: + description: >- + Acute myeloid leukemia characterized by the presence of abnormal bone marrow + eosinophils and the characteristic cytogenetic abnormality inv(16)(p13.1q22) + which results in the expression of the fusion protein CBFB-MYH11. + termDef: + term: >- + Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11 + source: NCIt + cde_id: C9018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9018" + term_id: C9018 + term_version: 20.05a + +acute_myeloid_leukemia_m6_type: + common: + description: >- + An acute myeloid leukemia characterized by a predominant immature erythroid + population. There are two subtypes recognized: erythroleukemia and pure erythroid + leukemia. (WHO, 2001) + termDef: + term: >- + Acute Erythroid Leukemia + source: NCIt + cde_id: C8923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8923" + term_id: C8923 + term_version: 20.05a + +acute_myeloid_leukemia_megakaryoblastic_with_t122p13q13_rbm15mkl1: + common: + description: >- + An acute myeloid leukemia associated with t(1;22)(p13.3;q13.1) resulting in + the expression of RBM15-MKL1 fusion protein. It affects infants and children + and usually shows megakaryocytic maturation. + termDef: + term: >- + Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 + source: NCIt + cde_id: C82427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82427" + term_id: C82427 + term_version: 20.05a + +acute_myeloid_leukemia_minimal_differentiation: + common: + description: >- + An acute myeloid leukemia (AML) in which the blasts do not show evidence of + myeloid differentiation by morphology and conventional cytochemistry. (WHO, + 2001) + termDef: + term: >- + Acute Myeloid Leukemia with Minimal Differentiation + source: NCIt + cde_id: C8460 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8460" + term_id: C8460 + term_version: 20.05a + +acute_myeloid_leukemia_mll: + common: + description: >- + An acute myeloid leukemia associated with t(9;11)(p21.3;q23.3) and MLLT3-KMT2A + fusion protein expression. Morphologically it usually has monocytic features. + It may present at any age but it is more commonly seen in children. Patients + may present with disseminated intravascular coagulation. + termDef: + term: >- + Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A + source: NCIt + cde_id: C82403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82403" + term_id: C82403 + term_version: 20.05a + +acute_myeloid_leukemia_nos: + common: + description: >- + Acute myeloid leukemias that do not fulfill the criteria for inclusion in the + group of acute myeloid leukemias which have recurrent genetic abnormalities + or myelodysplastic changes, or are therapy-related. This category includes + entities classified according to the French-American-British classification + scheme. + termDef: + term: >- + Acute Myeloid Leukemia Not Otherwise Specified + source: NCIt + cde_id: C27753 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27753" + term_id: C27753 + term_version: 20.05a + +acute_myeloid_leukemia_pmlraralpha: + common: + description: >- + An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. + It is characterized by the PML-RARA fusion. There are two variants: the typical + and microgranular variant. This AML is particularly sensitive to treatment + with all trans-retinoic acid and has a favorable prognosis. (WHO) + termDef: + term: >- + Acute Promyelocytic Leukemia with PML-RARA + source: NCIt + cde_id: C3182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3182" + term_id: C3182 + term_version: 20.05a + +acute_myeloid_leukemia_t1616p_13q_11: + common: + description: >- + Acute myeloid leukemia characterized by the presence of abnormal bone marrow + eosinophils and the characteristic cytogenetic abnormality t(16;16)(p13.1;q22) + which results in the expression of the fusion protein CBFB-MYH11. + termDef: + term: >- + Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11 + source: NCIt + cde_id: C9019 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9019" + term_id: C9019 + term_version: 20.05a + +acute_myeloid_leukemia_with_abnormal_marrow_eosinophils_includes_all_variants: + common: + description: >- + An acute myeloid leukemia with monocytic and granulocytic differentiation and + the presence of a characteristically abnormal eosinophil component in the bone + marrow. This type of acute myeloid leukemia has a favorable prognosis. (WHO, + 2001) + termDef: + term: >- + Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 + source: NCIt + cde_id: C9287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9287" + term_id: C9287 + term_version: 20.05a + +acute_myeloid_leukemia_with_inv3q21q262_or_t33q21q262_rpn1evi1: + common: + description: >- + An acute myeloid leukemia associated with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2) + resulting in the reposition of a distal GATA2 enhancer to activate MECOM expression. + It may present de novo or follow a myelodysplastic syndrome. The clinical course + is aggressive. + termDef: + term: >- + Acute Myeloid Leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2); + GATA2, MECOM + source: NCIt + cde_id: C82426 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82426" + term_id: C82426 + term_version: 20.05a + +acute_myeloid_leukemia_with_maturation: + common: + description: >- + An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation + to more mature neutrophils. (WHO, 2001) + termDef: + term: >- + Acute Myeloid Leukemia with Maturation + source: NCIt + cde_id: C3250 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3250" + term_id: C3250 + term_version: 20.05a + +acute_myeloid_leukemia_with_multilineage_dysplasia: + common: + description: >- + An acute myeloid leukemia arising de novo and not as a result of treatment. + It is characterized by the presence of myelodysplastic features in at least + 50% of the cells of at least two hematopoietic cell lines. Patients often present + with severe cytopenia. + termDef: + term: >- + Acute Myeloid Leukemia with Multilineage Dysplasia + source: NCIt + cde_id: C9289 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9289" + term_id: C9289 + term_version: 20.05a + +acute_myeloid_leukemia_with_mutated_cebpa: + common: + description: >- + An acute myeloid leukemia with non-germline mutations of the CEBPA gene. + termDef: + term: >- + Acute Myeloid Leukemia with Mutated CEBPA + source: NCIt + cde_id: C82433 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82433" + term_id: C82433 + term_version: 20.05a + +acute_myeloid_leukemia_with_mutated_npm1: + common: + description: >- + An acute myeloid leukemia with mutation of the nucleophosmin gene. It is usually + associated with normal karyotype and frequently has myelomonocytic or monocytic + features. It usually responds to induction therapy. + termDef: + term: >- + Acute Myeloid Leukemia with Mutated NPM1 + source: NCIt + cde_id: C82431 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82431" + term_id: C82431 + term_version: 20.05a + +acute_myeloid_leukemia_with_myelodysplasiarelated_changes: + common: + description: >- + An acute myeloid leukemia with at least 20% blasts in the bone marrow or blood, + and either a previous history of myelodysplastic syndrome, multilineage dysplasia + or myelodysplastic syndrome-related cytogenetic abnormalities. There is no + history of prior cytotoxic therapy for an unrelated disorder, and there is absence + of the cytogenetic abnormalities that are present in acute myeloid leukemia + with recurrent genetic abnormalities. + termDef: + term: >- + Acute Myeloid Leukemia with Myelodysplasia-Related Changes + source: NCIt + cde_id: C7600 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7600" + term_id: C7600 + term_version: 20.05a + +acute_myeloid_leukemia_with_prior_myelodysplastic_syndrome: + common: + description: >- + An acute myeloid leukemia developing in patients with a prior history of myelodysplastic + syndrome. + termDef: + term: >- + Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome + source: NCIt + cde_id: C4037 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4037" + term_id: C4037 + term_version: 20.05a + +acute_myeloid_leukemia_with_t69p23q34_deknup214: + common: + description: >- + An acute myeloid leukemia associated with t(6;9)(p23;q34.1) resulting in DEK-NUP214(CAN) + fusion protein expression. It is often associated with multilineage dysplasia + and basophilia. It affects both children and adults and it usually has an unfavorable + clinical outcome. + termDef: + term: >- + Acute Myeloid Leukemia with t(6;9) (p23;q34.1); DEK-NUP214 + source: NCIt + cde_id: C82423 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82423" + term_id: C82423 + term_version: 20.05a + +acute_myeloid_leukemia_with_t821q22q22_runx1runx1t1: + common: + description: >- + An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 + fusion transcript and showing maturation in the neutrophil lineage. The bone + marrow and the peripheral blood show large myeloblasts with abundant basophilic + cytoplasm, often containing azurophilic granules. This type of AML is associated + with good response to chemotherapy and high complete remission rate. + termDef: + term: >- + Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 + source: NCIt + cde_id: C9288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9288" + term_id: C9288 + term_version: 20.05a + +acute_myeloid_leukemia_with_t911p22q23_mllt3mll: + common: + description: >- + An acute myeloid leukemia associated with t(9;11)(p21.3;q23.3) and MLLT3-KMT2A + fusion protein expression. Morphologically it usually has monocytic features. + It may present at any age but it is more commonly seen in children. Patients + may present with disseminated intravascular coagulation. + termDef: + term: >- + Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A + source: NCIt + cde_id: C82403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82403" + term_id: C82403 + term_version: 20.05a + +acute_myeloid_leukemia_without_maturation: + common: + description: >- + An acute myeloid leukemia (AML) characterized by blasts without evidence of + maturation to more mature neutrophils. (WHO, 2001) + termDef: + term: >- + Acute Myeloid Leukemia without Maturation + source: NCIt + cde_id: C3249 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3249" + term_id: C3249 + term_version: 20.05a + +acute_myeloid_leukemia_without_prior_myelodysplastic_syndrome: + common: + description: >- + An acute myeloid leukemia developing in patients with a prior history of myelodysplastic + syndrome. + termDef: + term: >- + Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome + source: NCIt + cde_id: C4037 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4037" + term_id: C4037 + term_version: 20.05a + +acute_myelomonocytic_leukemia: + common: + description: >- + An acute leukemia characterized by the proliferation of both neutrophil and + monocyte precursors. (WHO, 2001) + termDef: + term: >- + Acute Myelomonocytic Leukemia + source: NCIt + cde_id: C7463 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7463" + term_id: C7463 + term_version: 20.05a + +acute_myelomonocytic_leukemia_with_abnormal_eosinophils: + common: + description: >- + Acute myelomonocytic leukemia characterized by the presence of abnormal bone + marrow eosinophils. It is associated with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22). + It has a favorable prognosis. + termDef: + term: >- + Acute Myelomonocytic Leukemia with Abnormal Eosinophils + source: NCIt + cde_id: C9020 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9020" + term_id: C9020 + term_version: 20.05a + +acute_myelosclerosis_nos: + common: + description: >- + An acute myeloid leukemia characterized by bone marrow fibrosis without preexisting + primary myelofibrosis. + termDef: + term: >- + Acute Panmyelosis with Myelofibrosis + source: NCIt + cde_id: C4344 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4344" + term_id: C4344 + term_version: 20.05a + +acute_myloid_leukemia_11q23_abnormalities: + common: + description: >- + An acute myeloid leukemia associated with t(9;11)(p21.3;q23.3) and MLLT3-KMT2A + fusion protein expression. Morphologically it usually has monocytic features. + It may present at any age but it is more commonly seen in children. Patients + may present with disseminated intravascular coagulation. + termDef: + term: >- + Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A + source: NCIt + cde_id: C82403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82403" + term_id: C82403 + term_version: 20.05a + +acute_nonlymphocytic_leukemia: + common: + description: >- + A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. + The classification of acute myeloid leukemias (AMLs) encompasses four major + categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage + dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required + bone marrow or peripheral blood blast percentage for the diagnosis of AML is + 20% (WHO classification). + termDef: + term: >- + Acute Myeloid Leukemia + source: NCIt + cde_id: C3171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3171" + term_id: C3171 + term_version: 20.05a + +acute_panmyelosis_nos: + common: + description: >- + An acute myeloid leukemia characterized by bone marrow fibrosis without preexisting + primary myelofibrosis. + termDef: + term: >- + Acute Panmyelosis with Myelofibrosis + source: NCIt + cde_id: C4344 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4344" + term_id: C4344 + term_version: 20.05a + +acute_panmyelosis_with_myelofibrosis: + common: + description: >- + An acute myeloid leukemia characterized by bone marrow fibrosis without preexisting + primary myelofibrosis. + termDef: + term: >- + Acute Panmyelosis with Myelofibrosis + source: NCIt + cde_id: C4344 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4344" + term_id: C4344 + term_version: 20.05a + +acute_promyelocytic_leukaemia_pmlraralpha: + common: + description: >- + An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. + It is characterized by the PML-RARA fusion. There are two variants: the typical + and microgranular variant. This AML is particularly sensitive to treatment + with all trans-retinoic acid and has a favorable prognosis. (WHO) + termDef: + term: >- + Acute Promyelocytic Leukemia with PML-RARA + source: NCIt + cde_id: C3182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3182" + term_id: C3182 + term_version: 20.05a + +acute_promyelocytic_leukaemia_t1517q22q1112: + common: + description: >- + An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. + It is characterized by the PML-RARA fusion. There are two variants: the typical + and microgranular variant. This AML is particularly sensitive to treatment + with all trans-retinoic acid and has a favorable prognosis. (WHO) + termDef: + term: >- + Acute Promyelocytic Leukemia with PML-RARA + source: NCIt + cde_id: C3182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3182" + term_id: C3182 + term_version: 20.05a + +acute_promyelocytic_leukemia_nos: + common: + description: >- + An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. + It is characterized by the PML-RARA fusion. There are two variants: the typical + and microgranular variant. This AML is particularly sensitive to treatment + with all trans-retinoic acid and has a favorable prognosis. (WHO) + termDef: + term: >- + Acute Promyelocytic Leukemia with PML-RARA + source: NCIt + cde_id: C3182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3182" + term_id: C3182 + term_version: 20.05a + +acvr1: + common: + description: >- + This gene plays a role in the transforming growth factor-beta signal transduction + pathway through serine/threonine specificity. + termDef: + term: >- + ACVR1 Gene + source: NCIt + cde_id: C21267 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21267" + term_id: C21267 + term_version: 20.10d + +acvr2a: + common: + description: >- + This gene plays a role in the transforming growth factor-beta signal transduction + pathway through constitutive kinase activity. + termDef: + term: >- + ACVR2A Gene + source: NCIt + cde_id: C21271 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21271" + term_id: C21271 + term_version: 20.10d + +adamantinoma_malignant: + common: + description: >- + A low grade malignant neoplasm arising from the long bones. The tibia is the + most frequently affected bone site. Patients present with swelling which may + or may not be associated with pain. Morphologically, it is characterized by + a biphasic pattern consisting of an epithelial and an osteofibrous component. + The vast majority of cases recur if they are not treated with radical surgery. + In a minority of cases the tumor may metastasize to other anatomic sites including + lymph nodes, lungs, liver, brain, and skeleton. + termDef: + term: >- + Adamantinoma + source: NCIt + cde_id: C7644 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7644" + term_id: C7644 + term_version: 20.05a + +adamantinoma_nos: + common: + description: >- + A low grade malignant neoplasm arising from the long bones. The tibia is the + most frequently affected bone site. Patients present with swelling which may + or may not be associated with pain. Morphologically, it is characterized by + a biphasic pattern consisting of an epithelial and an osteofibrous component. + The vast majority of cases recur if they are not treated with radical surgery. + In a minority of cases the tumor may metastasize to other anatomic sites including + lymph nodes, lungs, liver, brain, and skeleton. + termDef: + term: >- + Adamantinoma + source: NCIt + cde_id: C7644 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7644" + term_id: C7644 + term_version: 20.05a + +adamantinoma_of_long_bones: + common: + description: >- + A low grade malignant neoplasm arising from the long bones. The tibia is the + most frequently affected bone site. Patients present with swelling which may + or may not be associated with pain. Morphologically, it is characterized by + a biphasic pattern consisting of an epithelial and an osteofibrous component. + The vast majority of cases recur if they are not treated with radical surgery. + In a minority of cases the tumor may metastasize to other anatomic sites including + lymph nodes, lungs, liver, brain, and skeleton. + termDef: + term: >- + Adamantinoma + source: NCIt + cde_id: C7644 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7644" + term_id: C7644 + term_version: 20.05a + +adenoacanthoma: + common: + description: >- + An invasive adenocarcinoma characterized by the presence of focal or extensive + transformation of malignant glandular cells to squamous epithelial cells. + termDef: + term: >- + Adenocarcinoma with Squamous Metaplasia + source: NCIt + cde_id: C4200 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4200" + term_id: C4200 + term_version: 20.05a + +adenoameloblastoma: + common: + description: >- + A benign, slow growing neoplasm arising from tooth-forming tissues. The vast + majority of cases are intraosseous and most often grow in the maxilla. It is + characterized by the presence of odontogenic epithelium which is embedded in + a connective tissue stroma. Local excision is curative and recurrences are very + rare. + termDef: + term: >- + Adenomatoid Odontogenic Tumor + source: NCIt + cde_id: C4310 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4310" + term_id: C4310 + term_version: 20.05a + +adenocarcinoid_tumor: + common: + description: >- + A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells + with morphologic and immunohistochemical characteristics of carcinoid tumor + and malignant glandular cells. + termDef: + term: >- + Combined Carcinoid and Adenocarcinoma + source: NCIt + cde_id: C4139 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4139" + term_id: C4139 + term_version: 20.05a + +adenocarcinoma_admixed_with_neuroendocrine_carcinoma: + common: + description: >- + A carcinoma that arises from the cervix and is characterized by the presence + of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component. + termDef: + term: >- + Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma + source: NCIt + cde_id: C127915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127915" + term_id: C127915 + term_version: 20.05a + +adenocarcinoma_combined_with_other_types_of_carcinoma: + common: + description: >- + A lung adenocarcinoma consisting of a bronchioloalveolar component and an invasive + adenocarcinomatous component. + termDef: + term: >- + Lung Adenocarcinoma with Mixed Bronchioloalveolar and Invasive Components + source: NCIt + cde_id: C65197 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65197" + term_id: C65197 + term_version: 20.05a + +adenocarcinoma_cylindroid: + common: + description: >- + A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic + epithelial cells form cylindrical spatial configurations (cribriform or classic + type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid + cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid + cystic carcinomas mostly occur in the salivary glands. Other primary sites + of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid + cystic carcinomas spread along nerve sheaths, resulting in severe pain, and + they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread + is characteristic. + termDef: + term: >- + Adenoid Cystic Carcinoma + source: NCIt + cde_id: C2970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2970" + term_id: C2970 + term_version: 20.05a + +adenocarcinoma_diffuse_type: + common: + description: >- + An adenocarcinoma characterized by the presence of a diffuse cellular infiltrate + which is composed of poorly cohesive cells with minimal or no glandular formations. + Representative example is the gastric diffuse adenocarcinoma. + termDef: + term: >- + Diffuse Type Adenocarcinoma + source: NCIt + cde_id: C4127 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4127" + term_id: C4127 + term_version: 20.05a + +adenocarcinoma_endocervical_type: + common: + description: >- + An adenocarcinoma characterized by the presence of malignant glandular epithelium + resembling the endocervical epithelium. + termDef: + term: >- + Adenocarcinoma, Endocervical Type + source: NCIt + cde_id: C66951 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66951" + term_id: C66951 + term_version: 20.05a + +adenocarcinoma_in_a_polyp_nos: + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular + cells in an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma in Adenomatous Polyp + source: NCIt + cde_id: C7676 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7676" + term_id: C7676 + term_version: 20.05a + +adenocarcinoma_in_adenomatous_polyp: + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular + cells in an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma in Adenomatous Polyp + source: NCIt + cde_id: C7676 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7676" + term_id: C7676 + term_version: 20.05a + +adenocarcinoma_in_adenomatous_polyposis_coli: + common: + description: >- + Adenocarcinomas developing in colorectal adenomas in patients with a history + of adenomatous polyposis coli. The mean age of development of adenocarcinoma + is about 40 years. + termDef: + term: >- + Adenocarcinoma in Adenomatous Polyposis Coli + source: NCIt + cde_id: C4134 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4134" + term_id: C4134 + term_version: 20.05a + +adenocarcinoma_in_multiple_adenomatous_polyps: + common: + description: >- + Adenocarcinomas developing in gastrointestinal tract adenomas in patients with + multiple adenomatous polyps. + termDef: + term: >- + Adenocarcinoma in Multiple Adenomatous Polyps + source: NCIt + cde_id: C4136 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4136" + term_id: C4136 + term_version: 20.05a + +adenocarcinoma_in_polypoid_adenoma: + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular + cells in an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma in Adenomatous Polyp + source: NCIt + cde_id: C7676 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7676" + term_id: C7676 + term_version: 20.05a + +adenocarcinoma_in_situ_in_a_polyp_nos: + common: + description: >- + An adenocarcinoma arising in a polyp. + termDef: + term: >- + Adenocarcinoma In Situ in a Polyp + source: NCIt + cde_id: C7680 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7680" + term_id: C7680 + term_version: 20.05a + +adenocarcinoma_in_situ_in_adenomatous_polyp: + common: + description: >- + A non-invasive adenocarcinoma arising from the neoplastic glandular cells in + an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma In Situ in Adenomatous Polyp + source: NCIt + cde_id: C7678 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7678" + term_id: C7678 + term_version: 20.05a + +adenocarcinoma_in_situ_in_polypoid_adenoma: + common: + description: >- + A non-invasive adenocarcinoma arising from the neoplastic glandular cells in + an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma In Situ in Adenomatous Polyp + source: NCIt + cde_id: C7678 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7678" + term_id: C7678 + term_version: 20.05a + +adenocarcinoma_in_situ_in_tubular_adenoma: + common: + description: >- + An intraepithelial adenocarcinoma arising from a tubular adenoma. + termDef: + term: >- + Adenocarcinoma In Situ in Tubular Adenoma + source: NCIt + cde_id: C7679 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7679" + term_id: C7679 + term_version: 20.05a + +adenocarcinoma_in_situ_in_tubulovillous_adenoma: + common: + description: >- + A non-invasive adenocarcinoma arising from a tubulovillous adenoma. + termDef: + term: >- + Adenocarcinoma In Situ in Tubulovillous Adenoma + source: NCIt + cde_id: C4144 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4144" + term_id: C4144 + term_version: 20.05a + +adenocarcinoma_in_situ_in_villous_adenoma: + common: + description: >- + A non-invasive adenocarcinoma arising from a villous adenoma. + termDef: + term: >- + Adenocarcinoma In Situ in Villous Adenoma + source: NCIt + cde_id: C8376 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8376" + term_id: C8376 + term_version: 20.05a + +adenocarcinoma_in_situ_mucinous: + common: + description: >- + A very rare lung adenocarcinoma in situ variant characterized by the presence + of tall columnar cells with basal nuclei and abundant cytoplasmic mucin. + termDef: + term: >- + Lung Mucinous Adenocarcinoma In Situ + source: NCIt + cde_id: C136717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C136717" + term_id: C136717 + term_version: 20.05a + +adenocarcinoma_in_situ_nonmucinous: + common: + description: >- + Lung adenocarcinoma in situ characterized by the presence of type II pneumocyte + and/or Clara cell differentiation. Almost all cases of lung adenocarcinoma in + situ are non-mucinous. + termDef: + term: >- + Lung Non-Mucinous Adenocarcinoma In Situ + source: NCIt + cde_id: C136716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C136716" + term_id: C136716 + term_version: 20.05a + +adenocarcinoma_in_situ_nos: + common: + description: >- + A lesion in which the normally situated glands are partially or completely replaced + by atypical cells with malignant characteristics. + termDef: + term: >- + Adenocarcinoma In Situ + source: NCIt + cde_id: C4123 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4123" + term_id: C4123 + term_version: 20.05a + +adenocarcinoma_in_tubolovillous_adenoma: + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from a tubulovillous adenoma. + termDef: + term: >- + Adenocarcinoma in Tubulovillous Adenoma + source: NCIt + cde_id: C4145 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4145" + term_id: C4145 + term_version: 20.05a + +adenocarcinoma_in_tubular_adenoma: + common: + description: >- + An adenocarcinoma arising from a tubular adenoma. + termDef: + term: >- + Adenocarcinoma in Tubular Adenoma + source: NCIt + cde_id: C7677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7677" + term_id: C7677 + term_version: 20.05a + +adenocarcinoma_in_villous_adenoma: + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from a villous adenoma. + termDef: + term: >- + Adenocarcinoma in Villous Adenoma + source: NCIt + cde_id: C4141 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4141" + term_id: C4141 + term_version: 20.05a + +adenocarcinoma_intestinal_type: + common: + description: >- + An adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. + Representative examples include gastric, gallbladder, and ampulla of Vater intestinal + type adenocarcinomas. + termDef: + term: >- + Intestinal-Type Adenocarcinoma + source: NCIt + cde_id: C4126 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4126" + term_id: C4126 + term_version: 20.05a + +adenocarcinoma_metastatic_nos: + common: + description: >- + An adenocarcinoma that has spread from its original site of growth to another + anatomic site. + termDef: + term: >- + Metastatic Adenocarcinoma + source: NCIt + cde_id: C4124 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4124" + term_id: C4124 + term_version: 20.05a + +adenocarcinoma_nos: + common: + description: >- + A common cancer characterized by the presence of malignant glandular cells. Morphologically, + adenocarcinomas are classified according to the growth pattern (e.g., papillary, + alveolar) or according to the secreting product (e.g., mucinous, serous). Representative + examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, + renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, + and prostate adenocarcinoma. + termDef: + term: >- + Adenocarcinoma + source: NCIt + cde_id: C2852 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2852" + term_id: C2852 + term_version: 20.05a + +adenocarcinoma_of_anal_ducts: + common: + description: >- + An anal adenocarcinoma arising from the epithelium of the anal glands. The + overlying anal mucosa does not show evidence of neoplastic changes. + termDef: + term: >- + Anal Glands Adenocarcinoma + source: NCIt + cde_id: C5609 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5609" + term_id: C5609 + term_version: 20.05a + +adenocarcinoma_of_anal_glands: + common: + description: >- + An anal adenocarcinoma arising from the epithelium of the anal glands. The + overlying anal mucosa does not show evidence of neoplastic changes. + termDef: + term: >- + Anal Glands Adenocarcinoma + source: NCIt + cde_id: C5609 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5609" + term_id: C5609 + term_version: 20.05a + +adenocarcinoma_of_rete_ovarii: + common: + description: >- + An exceptionally rare adenocarcinoma that arises from the rete ovarii. + termDef: + term: >- + Rete Ovarii Adenocarcinoma + source: NCIt + cde_id: C40017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40017" + term_id: C40017 + term_version: 20.05a + +adenocarcinoma_with_apocrine_metaplasia: + common: + description: >- + An invasive adenocarcinoma characterized by focal or extensive transformation + of the malignant glandular cells to cells with abundant, usually granular eosinophilic + cytoplasm. + termDef: + term: >- + Adenocarcinoma with Apocrine Metaplasia + source: NCIt + cde_id: C4202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4202" + term_id: C4202 + term_version: 20.05a + +adenocarcinoma_with_cartilaginous_and_osseous_metaplasia: + common: + description: >- + An invasive adenocarcinoma characterized by focal or extensive cartilage and/or + bone formation. + termDef: + term: >- + Adenocarcinoma with Cartilaginous and Osseous Metaplasia + source: NCIt + cde_id: C7683 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7683" + term_id: C7683 + term_version: 20.05a + +adenocarcinoma_with_cartilaginous_metaplasia: + common: + description: >- + An adenocarcinoma characterized by the presence of cartilaginous metaplasia. + termDef: + term: >- + Adenocarcinoma with Cartilaginous Metaplasia + source: NCIt + cde_id: C7685 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7685" + term_id: C7685 + term_version: 20.05a + +adenocarcinoma_with_mixed_subtypes: + common: + description: >- + A lung adenocarcinoma consisting of a bronchioloalveolar component and an invasive + adenocarcinomatous component. + termDef: + term: >- + Lung Adenocarcinoma with Mixed Bronchioloalveolar and Invasive Components + source: NCIt + cde_id: C65197 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65197" + term_id: C65197 + term_version: 20.05a + +adenocarcinoma_with_neuroendocrine_differentiation: + common: + description: >- + An invasive adenocarcinoma characterized by the presence of focal or extensive + neurosecretory cell differentiation with the formation of organoid patterns. + termDef: + term: >- + Adenocarcinoma with Neuroendocrine Differentiation + source: NCIt + cde_id: C66745 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66745" + term_id: C66745 + term_version: 20.05a + +adenocarcinoma_with_osseous_metaplasia: + common: + description: >- + An adenocarcinoma characterized by the presence of osseous metaplasia. + termDef: + term: >- + Adenocarcinoma with Osseous Metaplasia + source: NCIt + cde_id: C7684 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7684" + term_id: C7684 + term_version: 20.05a + +adenocarcinoma_with_spindle_cell_metaplasia: + common: + description: >- + An invasive adenocarcinoma characterized by focal or extensive transformation + of the malignant glandular cells to spindle-shaped cells. + termDef: + term: >- + Adenocarcinoma with Spindle Cell Metaplasia + source: NCIt + cde_id: C4201 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4201" + term_id: C4201 + term_version: 20.05a + +adenocarcinoma_with_squamous_metaplasia: + common: + description: >- + An invasive adenocarcinoma characterized by the presence of focal or extensive + transformation of malignant glandular cells to squamous epithelial cells. + termDef: + term: >- + Adenocarcinoma with Squamous Metaplasia + source: NCIt + cde_id: C4200 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4200" + term_id: C4200 + term_version: 20.05a + +adenocystic_carcinoma: + common: + description: >- + A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic + epithelial cells form cylindrical spatial configurations (cribriform or classic + type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid + cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid + cystic carcinomas mostly occur in the salivary glands. Other primary sites + of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid + cystic carcinomas spread along nerve sheaths, resulting in severe pain, and + they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread + is characteristic. + termDef: + term: >- + Adenoid Cystic Carcinoma + source: NCIt + cde_id: C2970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2970" + term_id: C2970 + term_version: 20.05a + +adenofibroma_nos: + common: + description: >- + A benign or borderline neoplasm characterized by the presence of connective + tissue stroma and epithelial structures. It occurs in the ovary, fallopian tube, + uterine corpus, and cervix. + termDef: + term: >- + Female Reproductive System Adenofibroma + source: NCIt + cde_id: C8984 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8984" + term_id: C8984 + term_version: 20.05a + +adenoid_basal_carcinoma: + common: + description: >- + A variant of basal cell carcinoma morphologically characterized by the presence + of thin strands of basaloid cells forming a reticulate pattern. + termDef: + term: >- + Skin Adenoid Basal Cell Carcinoma + source: NCIt + cde_id: C27535 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27535" + term_id: C27535 + term_version: 20.05a + +adenoid_cystic_carcinoma: + common: + description: >- + A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic + epithelial cells form cylindrical spatial configurations (cribriform or classic + type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid + cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid + cystic carcinomas mostly occur in the salivary glands. Other primary sites + of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid + cystic carcinomas spread along nerve sheaths, resulting in severe pain, and + they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread + is characteristic. + termDef: + term: >- + Adenoid Cystic Carcinoma + source: NCIt + cde_id: C2970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2970" + term_id: C2970 + term_version: 20.05a + +adenolipoma: + common: + description: >- + An adenoma in which the neoplastic epithelial cells are admixed with adipose + tissue cells. + termDef: + term: >- + Lipoadenoma + source: NCIt + cde_id: C4159 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4159" + term_id: C4159 + term_version: 20.05a + +adenolymphoma: + common: + description: >- + An adenoma characterized by an oncocytic, often papillary, epithelial component, + dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid + gland, and is the second most common benign parotid salivary gland tumor. A + strong association with smoking has been reported. It typically presents as + a painless swelling in the lower portion of the parotid gland. + termDef: + term: >- + Warthin Tumor + source: NCIt + cde_id: C2854 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2854" + term_id: C2854 + term_version: 20.05a + +adenoma_nos: + common: + description: >- + A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated + but non-invasive. The neoplastic epithelial cells may or may not display cellular + atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes + severe it is sometimes called carcinoma in situ. Representative examples are + pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas + (or adenomatous polyps) of the gastrointestinal tract. + termDef: + term: >- + Adenoma + source: NCIt + cde_id: C2855 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2855" + term_id: C2855 + term_version: 20.05a + +adenoma_of_nipple: + common: + description: >- + A benign epithelial neoplasm arising from the nipple. Signs and symptoms include + serous or sanguineous nipple discharge and nipple erosion. It is characterized + by the presence of aggregates of small tubules replacing the nipple stroma. + The tubules are lined by epithelial and myoepithelial cells. + termDef: + term: >- + Nipple Adenoma + source: NCIt + cde_id: C4192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4192" + term_id: C4192 + term_version: 20.05a + +adenomatoid_odontogenic_tumor: + common: + description: >- + A benign, slow growing neoplasm arising from tooth-forming tissues. The vast + majority of cases are intraosseous and most often grow in the maxilla. It is + characterized by the presence of odontogenic epithelium which is embedded in + a connective tissue stroma. Local excision is curative and recurrences are very + rare. + termDef: + term: >- + Adenomatoid Odontogenic Tumor + source: NCIt + cde_id: C4310 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4310" + term_id: C4310 + term_version: 20.05a + +adenomatoid_tumor_nos: + common: + description: >- + A benign neoplasm arising from mesothelial cells. It is characterized by the + formation of glandular and tubular patterns. It can occur in several anatomic + sites including the pleura, peritoneum, and epididymis. + termDef: + term: >- + Adenomatoid Tumor + source: NCIt + cde_id: C3762 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3762" + term_id: C3762 + term_version: 20.05a + +adenomatous_polyp_nos: + common: + description: >- + A polypoid neoplasm arising from the glandular epithelium. There is proliferation + of glandular cells which may display dysplastic cytologic features. Representative + examples include the adenomatous polyps of the colon and rectum. + termDef: + term: >- + Adenomatous Polyp + source: NCIt + cde_id: C3764 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3764" + term_id: C3764 + term_version: 20.05a + +adenomatous_polyposis_coli: + common: + description: >- + An autosomal dominant disorder, characterized by the presence of multiple adenomas + in the colon and rectum. It is caused by a germline mutation in the adenomatous + polyposis coli (APC) gene which is located on the long arm of chromosome 5. + The adenomas are most often tubular, and they have the tendency to progress + to adenocarcinoma. They can occur throughout the colon, but they tend to concentrate + in the rectum and sigmoid colon. The colorectal adenomas are detected during + endoscopic examination between the age of 10 and 20 years. The adenomas increase + in size and numbers with age, and there is usually progression of one or more + adenomas to adenocarcinoma. The mean age of development of adenocarcinoma is + about 40 years. Signs include rectal bleeding and mucousy diarrhea. + termDef: + term: >- + Familial Adenomatous Polyposis + source: NCIt + cde_id: C3339 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3339" + term_id: C3339 + term_version: 20.05a + +adenomyoma: + common: + description: >- + A benign neoplasm characterized by the presence of a glandular and a mesenchymal + (fibromyomatous) component. It occurs in the uterine corpus and the cervix. + A variant of adenomyoma associated with glandular architectural complexity is + called atypical polypoid adenomyoma. Simple polypectomy is usually curative. + Atypical polypoid adenomyoma may recur following polypectomy. + termDef: + term: >- + Adenomyoma + source: NCIt + cde_id: C3726 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3726" + term_id: C3726 + term_version: 20.05a + +adenosarcoma: + common: + description: >- + A low grade malignant neoplasm characterized by the presence of a benign epithelial + component (tubular and cleft-like glands) and a low grade sarcomatous component + that contains varying amounts of fibrous and smooth muscle tissues. In a minority + of cases, the sarcomatous component contains heterologous elements including + striated muscle, cartilage, and fat. It occurs in the uterine corpus, ovary, + fallopian tube, cervix, and vagina. It may recur and in a minority of cases + may metastasize to distant anatomic sites. + termDef: + term: >- + Adenosarcoma + source: NCIt + cde_id: C9474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9474" + term_id: C9474 + term_version: 20.05a + +adenosine_a2a_receptor_antagonist_cs3005: + common: + description: >- + An orally bioavailable immune checkpoint inhibitor and antagonist of the adenosine + A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic + activities. Upon administration, A2AR antagonist CS3005 selectively binds to + and inhibits A2AR expressed on T-lymphocytes. This prevents tumor-released adenosine + from interacting with the A2A receptors, thereby blocking the adenosine/A2AR-mediated + inhibition of T-lymphocytes. This results in the proliferation and activation + of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor + cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces + of T-cells and, upon activation by adenosine, inhibits their proliferation and + activation. Adenosine is often overproduced by cancer cells and plays a key + role in immunosuppression. + termDef: + term: >- + Adenosine A2A Receptor Antagonist CS3005 + source: NCIt + cde_id: C175468 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175468" + term_id: C175468 + term_version: 20.10d + +adenosquamous_carcinoma: + common: + description: >- + An invasive carcinoma composed of malignant glandular cells and malignant squamous + cells. + termDef: + term: >- + Adenosquamous Carcinoma + source: NCIt + cde_id: C3727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3727" + term_id: C3727 + term_version: 20.05a + +adenovirus_5f35human_guanylyl_cyclase_cpadre: + common: + description: >- + A recombinant adenoviral serotype 5 (Ad5) in which the Ad5-based vector fiber + is replaced by the fiber from the human B adenovirus serotype 35 (F35), encoding + for the human guanylyl cyclase C (hGCC), and fused to the synthetic Pan DR epitope + (PADRE), with potential antineoplastic and immunomodulating activities. Upon + intramuscular administration of the Ad5/F35-hGCC-PADRE, the Ad5/F35 targets + CD46, which is expressed widely on most tumor cells, and the virus is taken + up by cells. Once inside the cells, the virus expresses hGCC. The expressed + hGCC induces both humoral and cellular immune responses against tumor cells + expressing the hGCC antigen. This results in the immune-mediated killing of + tumor cells. The hGCC protein is normally restricted to intestinal epithelial + cells but is overexpressed by metastatic colorectal tumors. PADRE is a helper + T-lymphocyte epitope that is able to augment the magnitude and duration of the + cytotoxic T-lymphocyte (CTL) response. The inclusion of the chimeric Ad5/F35 + fiber increases viral uptake in cells through CD46. + termDef: + term: >- + Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE + source: NCIt + cde_id: C173640 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173640" + term_id: C173640 + term_version: 20.10d + +adenovirus_serotype_26expressing_hpv16_vaccine_jnj63682918: + common: + description: >- + A prime cancer vaccine comprised of a genetically engineered, replication-deficient + adenovirus serotype 26 (Ad26) encoding the oncogenic human papillomavirus 16 + (HPV16), with potential immunostimulating and antineoplastic activities. Upon + intramuscular administration of Ad26-expressing HPV16 vaccine JNJ-63682918, + the adenovirus infects and expresses HPV16. The expressed proteins stimulate + the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against + tumor cells expressing HPV16 antigens, thereby inducing tumor cell lysis. HPV16 + infection plays a key role in the development of a variety of cancers. + termDef: + term: >- + Adenovirus Serotype 26-expressing HPV16 Vaccine JNJ-63682918 + source: NCIt + cde_id: C167360 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167360" + term_id: C167360 + term_version: 20.10d + +adenovirus_serotype_26expressing_hpv18_vaccine_jnj63682931: + common: + description: >- + A prime cancer vaccine comprised of a genetically engineered, replication-deficient + adenovirus serotype 26 (Ad26) encoding the oncogenic human papillomavirus 18 + (HPV18), with potential immunostimulating and antineoplastic activities. Upon + intramuscular administration of Ad26-expressing HPV18 vaccine JNJ-63682931, + the adenovirus infects and expresses HPV18. The expressed proteins stimulate + the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against + tumor cells expressing HPV18 antigens, thereby inducing tumor cell lysis. HPV18 + infection plays a key role in the development of a variety of cancers. + termDef: + term: >- + Adenovirus Serotype 26-expressing HPV18 Vaccine JNJ-63682931 + source: NCIt + cde_id: C167361 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167361" + term_id: C167361 + term_version: 20.10d + +adnexal_carcinoma: + common: + description: >- + A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. + Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine + carcinoma, and pilomatrical carcinoma. + termDef: + term: >- + Adnexal Carcinoma + source: NCIt + cde_id: C3775 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3775" + term_id: C3775 + term_version: 20.05a + +adnexal_tumor_benign: + common: + description: >- + A benign epithelial neoplasm arising from the sebaceous or sweat glands. Representative + examples include sebaceous adenoma, tubular apocrine adenoma, and hidradenoma. + termDef: + term: >- + Skin Appendage Adenoma + source: NCIt + cde_id: C7580 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7580" + term_id: C7580 + term_version: 20.05a + +adopted_brother: + common: + description: >- + A male sibling who is legally adopted by one's biological parent or legal guardian. + termDef: + term: >- + Adopted Brother + source: NCIt + cde_id: C166195 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166195" + term_id: C166195 + term_version: 19.12e + +adopted_daughter: + common: + description: >- + A female child in the parent-child relationship established by a legal adoption + proceeding. + termDef: + term: >- + Adopted Daughter + source: NCIt + cde_id: C166131 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166131" + term_id: C166131 + term_version: 19.12e + +adopted_sister: + common: + description: >- + A female sibling who is legally adopted by one's biological parent or legal + guardian. + termDef: + term: >- + Adopted Sister + source: NCIt + cde_id: C166196 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166196" + term_id: C166196 + term_version: 19.12e + +adopted_son: + common: + description: >- + A male child in the parent-child relationship established by a legal adoption + proceeding. + termDef: + term: >- + Adopted Son + source: NCIt + cde_id: C166132 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166132" + term_id: C166132 + term_version: 19.12e + +adoptive_father: + common: + description: >- + A male parent in the parent-child relationship established by a legal adoption + proceeding. + termDef: + term: >- + Adoptive Father + source: NCIt + cde_id: C166133 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166133" + term_id: C166133 + term_version: 19.12e + +adoptive_mother: + common: + description: >- + A female parent in the parent-child relationship established by a legal adoption + proceeding. + termDef: + term: >- + Adoptive Mother + source: NCIt + cde_id: C166134 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166134" + term_id: C166134 + term_version: 19.12e + +adrenal_cortical_adenocarcinoma: + common: + description: >- + A rare, usually large (greater than 5cm), malignant epithelial tumor arising + from the adrenal cortical cells. Symptoms are usually related to the excessive + production of hormones, and include Cushing's syndrome and virilism in women. Common + sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced + radiologic procedures have enabled the detection of small tumors, resulting + in the improvement of the 5-year survival. + termDef: + term: >- + Adrenal Cortex Carcinoma + source: NCIt + cde_id: C9325 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9325" + term_id: C9325 + term_version: 20.05a + +adrenal_cortical_adenoma_clear_cell: + common: + description: >- + An adenoma of the adrenal cortex composed of neoplastic clear cells containing + intracytoplasmic lipid droplets. + termDef: + term: >- + Adrenal Cortex Clear Cell Adenoma + source: NCIt + cde_id: C4165 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4165" + term_id: C4165 + term_version: 20.05a + +adrenal_cortical_adenoma_compact_cell: + common: + description: >- + An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic + cytoplasm. + termDef: + term: >- + Adrenal Cortex Compact Cell Adenoma + source: NCIt + cde_id: C4163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4163" + term_id: C4163 + term_version: 20.05a + +adrenal_cortical_adenoma_glomerulosa_cell: + common: + description: >- + An adenoma of the adrenal cortex composed of neoplastic cells with cytologic + features of glomerulosa cells. + termDef: + term: >- + Adrenal Cortex Glomerulosa Cell Adenoma + source: NCIt + cde_id: C4166 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4166" + term_id: C4166 + term_version: 20.05a + +adrenal_cortical_adenoma_mixed_cell: + common: + description: >- + An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, + including varying numbers of neoplastic clear and compact cells. + termDef: + term: >- + Adrenal Cortex Mixed Cell Adenoma + source: NCIt + cde_id: C4167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4167" + term_id: C4167 + term_version: 20.05a + +adrenal_cortical_adenoma_nos: + common: + description: >- + A benign neoplasm that can arise from any of the adrenal cortical layers. It + can be associated with the overproduction of glucocorticoids (Cushing's syndrome), + androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids + (Conn's syndrome). (Sternberg Diagnostic Surgical Pathology, 3rd ed.) + termDef: + term: >- + Adrenal Cortex Adenoma + source: NCIt + cde_id: C9003 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9003" + term_id: C9003 + term_version: 20.05a + +adrenal_cortical_adenoma_pigmented: + common: + description: >- + A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark + brown appearance and is characterized by the presence of neoplastic cells containing + abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome. + termDef: + term: >- + Pigmented Adrenal Cortex Adenoma + source: NCIt + cde_id: C4164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4164" + term_id: C4164 + term_version: 20.05a + +adrenal_cortical_carcinoma: + common: + description: >- + A rare, usually large (greater than 5cm), malignant epithelial tumor arising + from the adrenal cortical cells. Symptoms are usually related to the excessive + production of hormones, and include Cushing's syndrome and virilism in women. Common + sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced + radiologic procedures have enabled the detection of small tumors, resulting + in the improvement of the 5-year survival. + termDef: + term: >- + Adrenal Cortex Carcinoma + source: NCIt + cde_id: C9325 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9325" + term_id: C9325 + term_version: 20.05a + +adrenal_cortical_tumor_benign: + common: + description: >- + A non-metastasizing neoplasm arising from the adrenal cortex. + termDef: + term: >- + Benign Adrenal Cortex Neoplasm + source: NCIt + cde_id: C9004 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9004" + term_id: C9004 + term_version: 20.05a + +adrenal_cortical_tumor_malignant: + common: + description: >- + A primary or metastatic malignant neoplasm affecting the adrenal cortex. + termDef: + term: >- + Malignant Adrenal Cortex Neoplasm + source: NCIt + cde_id: C9327 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9327" + term_id: C9327 + term_version: 20.05a + +adrenal_cortical_tumor_nos: + common: + description: >- + A benign or malignant (primary or metastatic) neoplasm affecting the adrenal + cortex. + termDef: + term: >- + Adrenal Cortex Neoplasm + source: NCIt + cde_id: C2858 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2858" + term_id: C2858 + term_version: 20.05a + +adrenal_gland: + common: + description: >- + A flattened, roughly triangular body resting upon the upper end of each kidney; + it is one of the ductless glands furnishing internal secretions (epinephrine + and norepinephrine from the medulla and steroid hormones from the cortex). + termDef: + term: >- + Adrenal Gland + source: NCIt + cde_id: C12666 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12666" + term_id: C12666 + term_version: 20.05a + +adrenal_gland_cancer: + common: + description: >- + A primary or metastatic malignant neoplasm affecting the adrenal gland. + termDef: + term: >- + Malignant Adrenal Gland Neoplasm + source: NCIt + cde_id: C9338 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9338" + term_id: C9338 + term_version: 19.12e + +adrenal_gland_nos: + common: + description: >- + A flattened, roughly triangular body resting upon the upper end of each kidney; + it is one of the ductless glands furnishing internal secretions (epinephrine + and norepinephrine from the medulla and steroid hormones from the cortex). + termDef: + term: >- + Adrenal Gland + source: NCIt + cde_id: C12666 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12666" + term_id: C12666 + term_version: 20.05a + +adrenal_medullary_paraganglioma: + common: + description: >- + A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system + that secretes catecholamines. It arises from the chromaffin cells of the adrenal + medulla. Clinical presentation includes headaches, palpitations, chest and + abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic + nesting (zellballen) growth pattern is usually seen. Other growth patterns + including trabecular pattern may also be present. + termDef: + term: >- + Adrenal Gland Pheochromocytoma + source: NCIt + cde_id: C3326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3326" + term_id: C3326 + term_version: 20.05a + +adrenal_medullary_paraganglioma_malignant: + common: + description: >- + A pheochromocytoma that metastasizes to other anatomic sites. Common sites + of metastasis include lymph nodes, bones, liver, and lung. Morphologic features + associated with malignant pheochromocytomas include: atypical mitotic figures, + capsular and vascular invasion, tumor cell necrosis, and high mitotic activity. + termDef: + term: >- + Malignant Adrenal Gland Pheochromocytoma + source: NCIt + cde_id: C4220 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4220" + term_id: C4220 + term_version: 20.05a + +adrenal_rest_tumor: + common: + description: >- + A benign, testicular or ovarian tumor, derived from adrenal embryonic rest cells. + It is composed of hyperplastic adrenal cortical tissue, and it is associated + with congenital adrenal hyperplasia. + termDef: + term: >- + Adrenal Rest Tumor + source: NCIt + cde_id: C2860 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2860" + term_id: C2860 + term_version: 20.05a + +adult_cystic_teratoma: + common: + description: >- + Adult Cystic Teratoma + termDef: + term: >- + Adult Cystic Teratoma + source: NCIt + cde_id: C9012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9012" + term_id: C9012 + term_version: 20.05a + +adult_granulosa_cell_tumor: + common: + description: >- + A granulosa cell tumor occurring in the ovary and rarely in the testis. It is + composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic + cells may form various patterns including the microfollicular, which is characterized + by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, + and diffuse pattern. In females, it affects middle aged to post-menopausal women. + Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic + and rarely androgenic manifestations may be present. The vast majority of cases + present as stage I tumors; however, all tumors have a potential for aggressive + clinical course. In males, it is reported in the age range of 16-76 years and + the average age at presentation is 44 years. A minority of patients have gynecomastia. + Metastases have been reported in a minority of patients. + termDef: + term: >- + Adult Type Granulosa Cell Tumor + source: NCIt + cde_id: C66750 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66750" + term_id: C66750 + term_version: 20.05a + +adult_tcell_leukemia: + common: + description: >- + A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus + type 1 (HTLV-1). Adult T-cell leukemia/lymphoma is endemic in several regions + of the world, in particular Japan, the Caribbean, and parts of Central Africa. + termDef: + term: >- + Adult T-Cell Leukemia/Lymphoma + source: NCIt + cde_id: C3184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3184" + term_id: C3184 + term_version: 20.05a + +adult_tcell_leukemialymphoma_htlv1_positive_includes_all_variants: + common: + description: >- + A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus + type 1 (HTLV-1). Adult T-cell leukemia/lymphoma is endemic in several regions + of the world, in particular Japan, the Caribbean, and parts of Central Africa. + termDef: + term: >- + Adult T-Cell Leukemia/Lymphoma + source: NCIt + cde_id: C3184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3184" + term_id: C3184 + term_version: 20.05a + +adult_tcell_lymphoma: + common: + description: >- + A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus + type 1 (HTLV-1). Adult T-cell leukemia/lymphoma is endemic in several regions + of the world, in particular Japan, the Caribbean, and parts of Central Africa. + termDef: + term: >- + Adult T-Cell Leukemia/Lymphoma + source: NCIt + cde_id: C3184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3184" + term_id: C3184 + term_version: 20.05a + +adult_tcell_lymphomaleukemia: + common: + description: >- + A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus + type 1 (HTLV-1). Adult T-cell leukemia/lymphoma is endemic in several regions + of the world, in particular Japan, the Caribbean, and parts of Central Africa. + termDef: + term: >- + Adult T-Cell Leukemia/Lymphoma + source: NCIt + cde_id: C3184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3184" + term_id: C3184 + term_version: 20.05a + +adult_teratoma_nos: + common: + description: >- + Adult Teratoma + termDef: + term: >- + Adult Teratoma + source: NCIt + cde_id: C9013 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9013" + term_id: C9013 + term_version: 20.05a + +aff1: + common: + description: >- + This gene is involved in transcriptional regulation and translocations in the + gene are associated with acute leukemia. + termDef: + term: >- + AFF1 Gene + source: NCIt + cde_id: C24602 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24602" + term_id: C24602 + term_version: 20.10d + +aff3: + common: + description: >- + This gene is involved in transcriptional activation and is purported to play + roles in lymphoid development and oncogenesis. + termDef: + term: >- + AFF3 Gene + source: NCIt + cde_id: C24538 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24538" + term_id: C24538 + term_version: 20.10d + +aff4: + common: + description: >- + This gene plays a regulatory role in transcription and is involved in male germ + cell differentiation. + termDef: + term: >- + AFF4 Gene + source: NCIt + cde_id: C21385 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21385" + term_id: C21385 + term_version: 20.10d + +afghanistan: + common: + description: >- + A country in southern Asia, north and west of Pakistan, east of Iran. + termDef: + term: >- + Afghanistan + source: NCIt + cde_id: C16267 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16267" + term_id: C16267 + term_version: 19.12e + +after_60_minutes: + common: + description: >- + An indication that more than 60 minutes passes between waking and smoking the + first cigarette of the day. + termDef: + term: >- + Time Between Waking and First Smoke - After 60 Minutes + source: NCIt + cde_id: C164127 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164127" + term_id: C164127 + term_version: 19.12e + +aggressive_angiomyxoma: + common: + description: >- + A locally infiltrating, non-metastasizing angiomyxoma arising from the pelviperineal + region. It may recur following resection + termDef: + term: >- + Deep "Aggressive" Angiomyxoma + source: NCIt + cde_id: C6936 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6936" + term_id: C6936 + term_version: 20.05a + +aggressive_fibromatosis: + common: + description: >- + An insidious, locally aggressive, poorly circumscribed neoplasm arising from + the deep soft tissues. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + It lacks metastatic potential. + termDef: + term: >- + Desmoid-Type Fibromatosis + source: NCIt + cde_id: C9182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9182" + term_id: C9182 + term_version: 20.05a + +aggressive_nkcell_leukaemia: + common: + description: >- + A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known + as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart + of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers + and young adults. It is characterized by the systemic proliferation of NK cells + in the peripheral blood, bone marrow, liver, and spleen. + termDef: + term: >- + Aggressive NK-Cell Leukemia + source: NCIt + cde_id: C8647 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8647" + term_id: C8647 + term_version: 20.05a + +aggressive_osteoblastoma: + common: + description: >- + An osteoblastoma characterized by the presence of prominent epithelioid osteoblasts + and recurrences. + termDef: + term: >- + Aggressive Osteoblastoma + source: NCIt + cde_id: C66796 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66796" + term_id: C66796 + term_version: 20.05a + +aggressive_systemic_mastocytosis: + common: + description: >- + An aggressive and progressive mast cell neoplasm characterized by systemic infiltration + of internal organs by aggregates of neoplastic mast cells. There is no evidence + of mast cell leukemia or clonal hematologic malignancy. Clinical symptoms include + hepatomegaly, splenomegaly, portal hypertension, malabsorption syndrome, and + pathologic fractures. + termDef: + term: >- + Aggressive Systemic Mastocytosis + source: NCIt + cde_id: C9285 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9285" + term_id: C9285 + term_version: 20.05a + +agnogenic_myeloid_metaplasia: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, + proliferation of atypical megakaryocytes and granulocytes in the bone marrow, + anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001) + termDef: + term: >- + Primary Myelofibrosis + source: NCIt + cde_id: C2862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2862" + term_id: C2862 + term_version: 20.05a + +ain_iii: + common: + description: >- + Anal canal or perianal skin intraepithelial neoplasia with severe dysplasia. + termDef: + term: >- + Anal Intraepithelial Neoplasia 3 + source: NCIt + cde_id: C157575 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157575" + term_id: C157575 + term_version: 20.05a + +aircraft_smoke: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced when an aircraft is in operation. + termDef: + term: >- + Aircraft Smoke Exposure + source: NCIt + cde_id: C164072 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164072" + term_id: C164072 + term_version: 19.12e + +ajadjuvant_therapy: + common: + description: >- + Any therapy that is administered to augment or stimulate other treatment modalities + or to minimize or prevent disease recurrence subsequent to the main treatment + plan. + termDef: + term: >- + Adjuvant Therapy + source: NCIt + cde_id: C15675 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15675" + term_id: C15675 + term_version: 20.05a + +akap9: + common: + description: >- + This gene plays a role in signal transduction and modulates synaptic transmission. + termDef: + term: >- + AKAP9 Gene + source: NCIt + cde_id: C21305 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21305" + term_id: C21305 + term_version: 20.10d + +akt1: + common: + description: >- + This gene is involved in signal transduction and negative regulation of apoptosis. + It also plays a role in glucose transport, glycogen synthesis, protein synthesis + and neuronal survival. + termDef: + term: >- + AKT1 Gene + source: NCIt + cde_id: C18350 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18350" + term_id: C18350 + term_version: 20.10d + +akt2: + common: + description: >- + This gene plays a role in glucose homeostasis and the inhibition of apoptosis. + termDef: + term: >- + AKT2 Gene + source: NCIt + cde_id: C18352 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18352" + term_id: C18352 + term_version: 20.10d + +akt3: + common: + description: >- + This gene is involved in signal transduction and the inhibition of apoptosis. + termDef: + term: >- + AKT3 Gene + source: NCIt + cde_id: C20937 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20937" + term_id: C20937 + term_version: 20.10d + +albania: + common: + description: >- + A country in southeastern Europe, bordering the Adriatic and Ionian Seas, between + Greece and Montenegro. + termDef: + term: >- + Albania + source: NCIt + cde_id: C16271 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16271" + term_id: C16271 + term_version: 19.12e + +albumin: + common: + description: >- + A quantitative measurement of albumin present in a sample. + termDef: + term: >- + Albumin Measurement + source: NCIt + cde_id: C64431 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64431" + term_id: C64431 + term_version: 20.10d + +aldh2: + common: + description: >- + This gene plays a role in intermediary metabolism. + termDef: + term: >- + ALDH2 Gene + source: NCIt + cde_id: C84921 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84921" + term_id: C84921 + term_version: 20.10d + +aleukemic_leukemia_nos: + common: + description: >- + A leukemia characterized by the absence of leukemic cells in the peripheral + blood. + termDef: + term: >- + Aleukemic Leukemia + source: NCIt + cde_id: C4982 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4982" + term_id: C4982 + term_version: 20.05a + +aleukemic_lymphatic_leukemia: + common: + description: >- + Aleukemic Lymphoid Leukemia + termDef: + term: >- + Aleukemic Lymphoid Leukemia + source: NCIt + cde_id: C4343 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4343" + term_id: C4343 + term_version: 20.05a + +aleukemic_lymphocytic_leukemia: + common: + description: >- + Aleukemic Chronic Lymphocytic Leukemia + termDef: + term: >- + Aleukemic Chronic Lymphocytic Leukemia + source: NCIt + cde_id: C7176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7176" + term_id: C7176 + term_version: 20.05a + +aleukemic_lymphoid_leukemia: + common: + description: >- + Aleukemic Lymphoid Leukemia + termDef: + term: >- + Aleukemic Lymphoid Leukemia + source: NCIt + cde_id: C4343 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4343" + term_id: C4343 + term_version: 20.05a + +algeria: + common: + description: >- + A country in northern Africa, bordering the Mediterranean Sea, between Morocco + and Tunisia. + termDef: + term: >- + Algeria + source: NCIt + cde_id: C16274 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16274" + term_id: C16274 + term_version: 19.12e + +alive: + common: + description: >- + Living; showing characteristics of life. + termDef: + term: >- + Alive + source: NCIt + cde_id: C37987 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37987" + term_id: C37987 + term_version: 19.12e + +alk: + common: + description: >- + This gene is involved in brain development and neuronal specificity. + termDef: + term: >- + ALK Gene + source: NCIt + cde_id: C38184 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38184" + term_id: C38184 + term_version: 20.10d + +alk_inhibitor_tae684: + common: + description: >- + A small molecule inhibitor of the receptor tyrosine kinases (RTKs) anaplastic + lymphoma kinase (ALK) and nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), + with potential antineoplastic activity. Upon administration, TAE684 binds to + and inhibits ALK and NPM-ALK tyrosine kinases, which leads to a disruption of + ALK- and NPM-ALK mediated signaling and eventually inhibits tumor cell growth + in ALK- and NPM-ALK overexpressing tumor cells. ALK belongs to the insulin receptor + superfamily and plays an important role in nervous system development. ALK dysregulation + and gene rearrangements are associated with a series of tumors. NPM-ALK is an + oncogenic fusion protein associated with ALK-positive anaplastic large cell + lymphoma. ALK mutations are also associated with acquired resistance to small + molecule tyrosine kinase inhibitors. + termDef: + term: >- + ALK Inhibitor TAE684 + source: NCIt + cde_id: C171615 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171615" + term_id: C171615 + term_version: 20.10d + +alk_positive_large_bcell_lymphoma: + common: + description: >- + A usually aggressive large B-cell lymphoma characterized by the presence of + monomorphic immunoblast-like neoplastic B-lymphocytes in a sinusoidal growth + pattern. The neoplastic B-lymphocytes express the ALK kinase but they lack + the 2;5 translocation. + termDef: + term: >- + ALK-Positive Large B-Cell Lymphoma + source: NCIt + cde_id: C7225 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7225" + term_id: C7225 + term_version: 20.05a + +alkros1met_inhibitor_tqb3101: + common: + description: >- + An orally available, small molecule inhibitor of the receptor tyrosine kinases + anaplastic lymphoma kinase (ALK), C-ros oncogene 1 (ROS1) and Met (hepatocyte + growth factor receptor; HGFR; c-Met), with potential antineoplastic activity. + Upon oral administration, TQ-B3101 targets, binds to and inhibits the activity + of ALK, ROS1 and c-Met, which leads to the disruption of ALK-, ROS1- and c-Met-mediated + signaling and the inhibition of cell growth in ALK-, ROS1- and c-Met-expressing + tumor cells. ALK, ROS1 and c-Met, overexpressed or mutated in many tumor cell + types, play key roles in tumor cell proliferation, survival, invasion and metastasis. + termDef: + term: >- + ALK/ROS1/Met Inhibitor TQ-B3101 + source: NCIt + cde_id: C173430 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173430" + term_id: C173430 + term_version: 20.10d + +alleles: + common: + description: >- + Mutually exclusive alternative forms of the same gene occupying the same locus + on homologous chromosomes, differing in nucleotide sequence and governing the + same biochemical and developmental process. + termDef: + term: >- + Allele + source: NCIt + cde_id: C16277 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16277" + term_id: C16277 + term_version: 20.10d + +allogeneic_antibcma_cartransduced_tcells_allo715: + common: + description: >- + A preparation of allogeneic, 'off-the-shelf' (OTS), universal transcription + activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes + that have been transduced with a vector expressing a chimeric antigen receptor + (CAR) containing a single chain variable fragment (scFv) derived from a monoclonal + antibody specific for the human tumor-associated antigen (TAA) B-cell maturation + antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), + with potential immunostimulating and antineoplastic activities. Using TALEN + technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are + deleted from the CAR T-cells. Upon administration, the allogeneic anti-BCMA + CAR-transduced T-cells ALLO-715 specifically recognize and induce selective + toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing + ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor + necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces + of plasma cells, is overexpressed on malignant plasma cells and plays a key + role in plasma cell proliferation and survival. Deletion of the CD52 gene makes + the modified donor T-cells resistant to an anti-CD52 monoclonal antibody treatment, + that is used during lymphodepletion. The knockout of TRAC eliminates TCR expression + and is intended to abrogate the potential induction of graft-versus-host disease + (GvHD) by the donor T-cells. The donor-derived, gene-edited CAR T cells have + reduced production times and have increased availability when compared to autologous + CAR-T cells, which use the patient's own cells and are produced on an individual + basis. In addition, if the ALLO-715 cells cause unacceptable side effects, the + incorporated CD20-based off-switch permits selective depletion of the ALLO-715 + cells when the anti-CD20 monoclonal antibody rituximab is administered. + termDef: + term: >- + Allogeneic Anti-BCMA CAR-transduced T-cells ALLO-715 + source: NCIt + cde_id: C165779 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165779" + term_id: C165779 + term_version: 20.10d + +allogeneic_antibcmacar_tcells_pbcar269a: + common: + description: >- + A preparation of allogeneic, off-the-shelf, T-lymphocytes that have been genetically + modified using a proprietary synthetic nuclease-based system to express a chimeric + antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation + antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), + with potential immunostimulating and antineoplastic activities. Upon administration, + allogeneic anti-BCMA-CAR T-cells PBCAR269A specifically recognize and kill BCMA-expressing + tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) + and B-cell activating factor (BAFF), is a member of the tumor necrosis factor + receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, + is overexpressed on malignant plasma cells and plays a key role in plasma cell + proliferation and survival. + termDef: + term: >- + Allogeneic Anti-BCMA-CAR T-cells PBCAR269A + source: NCIt + cde_id: C171066 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171066" + term_id: C171066 + term_version: 20.10d + +allogeneic_antibcmacs1_bispecific_cart_cells: + common: + description: >- + A preparation of allogeneic T-lymphocytes that have been genetically modified + to express a chimeric antigen receptor (CAR) targeting both the tumor-associated + antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and human CS1 (CD2 + subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential immunomodulating + and antineoplastic activities. Upon administration, the allogeneic anti-BCMA/CS1 + bispecific CAR-T cells target and bind to tumor cells expressing BCMA and/or + CS1 and induce selective cytotoxicity in those cells. BCMA, a receptor for both + a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), + is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA + is found on the surfaces of plasma cells, is overexpressed on malignant plasma + cells and plays a key role in plasma cell proliferation and survival. SLAMF7 + is a member of the signaling lymphocytic activation molecule (SLAM) family of + transmembrane receptors that modulate the function of immune cells through immunoreceptor + tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 + is highly expressed on certain malignant plasma cells and is minimally expressed + on healthy immune cells. Targeting the two different TAAs highly expressed on + malignant plasma cells may improve coverage and protect against antigen escape + and resistance as tumor cells would need to lose both antigens. + termDef: + term: >- + Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells + source: NCIt + cde_id: C173967 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173967" + term_id: C173967 + term_version: 20.10d + +allogeneic_anticd19_car_tcells_allo501a: + common: + description: >- + A preparation of allogeneic, frozen, 'off-the-shelf', universal transcription + activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes + expressing a chimeric antigen receptor (CAR) targeting the tumor-associated + antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. + Using TALEN technology, the T-cell receptor (TCR) alpha chain and CD52 genes + are deleted from the CAR19 T-cells. Upon administration, allogeneic anti-CD19 + CAR T-cells ALLO-501A specifically target and bind to CD19-expressing tumor + cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen + is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. + Deletion of the CD52 gene makes the modified donor T-cells resistant to the + anti-CD52 monoclonal antibody alemtuzumab, which is used during lymphodepletion. + The knockout of the TCR alpha gene eliminates TCR expression and is intended + to abrogate the potential induction of graft-versus-host disease (GvHD) by the + donor T-cells. ALLO-501A lacks the rituximab recognition domains of ALLO-501. + termDef: + term: >- + Allogeneic Anti-CD19 CAR T-cells ALLO-501A + source: NCIt + cde_id: C172708 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172708" + term_id: C172708 + term_version: 20.10d + +allogeneic_anticd19_universal_cart_cells_cta101: + common: + description: >- + A preparation of allogeneic, off-the-shelf (OTS), universal, gene-edited T-lymphocytes + expressing a chimeric antigen receptor (CAR) targeting the tumor-associated + antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities. + Upon administration, allogeneic anti-CD19 universal CAR-T cells CTA101 specifically + target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing + tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed + in B-cell lineage malignancies. CTA101 is genetically engineered to prevent + graft-versus-host disease (GvHD) by the donor T-cells. OTS CAR-T cells require + reduced production times when compared to autologous CAR-T cells. + termDef: + term: >- + Allogeneic Anti-CD19 Universal CAR-T Cells CTA101 + source: NCIt + cde_id: C173959 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173959" + term_id: C173959 + term_version: 20.10d + +allogeneic_anticd20_car_tcells_lucar20s: + common: + description: >- + A preparation of donor-derived T-lymphocytes that have been genetically modified + to express a chimeric antigen receptor (CAR) targeting the tumor-associated + antigen (TAA) CD20 (cluster of differentiation 20), with potential immunostimulating + and antineoplastic activities. Upon administration, allogeneic anti-CD20 CAR + T-cells LUCAR-20S specifically recognize and kill CD20-expressing tumor cells. + The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell + specific cell surface antigen expressed in B-cell lineage malignancies. + termDef: + term: >- + Allogeneic Anti-CD20 CAR T-cells LUCAR-20S + source: NCIt + cde_id: C174397 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174397" + term_id: C174397 + term_version: 20.10d + +allogeneic_anticd20car_tcells_pbcar20a: + common: + description: >- + A preparation of allogeneic, off-the-shelf (OTS), T-lymphocytes, derived from + healthy donors, that have been genetically modified using a proprietary synthetic + endonuclease-based system to express a chimeric antigen receptor (CAR) targeting + the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), with + potential immunostimulating and antineoplastic activities. Upon administration, + allogeneic anti-CD20-CAR T-cells PBCAR20A specifically recognize and kill CD20-expressing + tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, + is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies. + termDef: + term: >- + Allogeneic Anti-CD20-CAR T-cells PBCAR20A + source: NCIt + cde_id: C168570 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168570" + term_id: C168570 + term_version: 20.10d + +allogeneic_cd22specific_universal_carexpressing_tlymphocytes_ucart22: + common: + description: >- + A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like + effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically + modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated + antigen (TAA) human CD22 with potential immunomodulating and antineoplastic + activities. Upon transfusion, allogeneic CD22-specific universal CAR-expressing + T-lymphocytes UCART22 express anti-CD22-CAR on their cell surfaces and bind + to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing + tumor cells. CD22, a cell surface glycoprotein, is expressed on mature B-cells + and on most malignant B-cells. + termDef: + term: >- + Allogeneic CD22-specific Universal CAR-expressing T-lymphocytes UCART22 + source: NCIt + cde_id: C165696 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165696" + term_id: C165696 + term_version: 20.10d + +allogeneic_cd56positive_cd3negative_natural_killer_cells_cynk001: + common: + description: >- + A population of cryopreserved, off-the-shelf (OTS) allogeneic natural killer + (NK) cells derived from human placental hematopoietic stem cells (HSCs) and + expressing the CD56 surface antigen and exhibiting a lack of CD3, with potential + immunomodulating, antineoplastic and antiviral activities. Upon infusion of + allogeneic CD56-positive CD3-negative NK cells CYNK-001, these cells are able + to recognize tumor cells as well as virally-infected cells, secrete perforins, + granzymes and cytokines, and induce apoptosis in tumor and virally-infected + cells. + termDef: + term: >- + Allogeneic CD56-positive CD3-negative Natural Killer Cells CYNK-001 + source: NCIt + cde_id: C173877 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173877" + term_id: C173877 + term_version: 20.10d + +allogeneic_cd8_leukemiaassociated_antigens_specific_t_cells_nexi001: + common: + description: >- + A preparation of allogeneic CD8+ T cells targeting multiple undisclosed leukemia-associated + antigens, with potential immunomodulating and antineoplastic activities. Following + peripheral blood mononuclear cell (PBMC) collection from the original stem cell + donor and ex vivo priming and expansion, the allogeneic CD8+ leukemia-associated + antigens specific T cells NEXI-001 are re-introduced into the leukemia patient, + where they target and kill tumor cells expressing these leukemia-associated + antigens. + termDef: + term: >- + Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001 + source: NCIt + cde_id: C170887 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170887" + term_id: C170887 + term_version: 20.10d + +allogeneic_crisprcas9_engineered_antibcma_t_cells_ctx120: + common: + description: >- + A preparation of human allogeneic T-lymphocytes gene-edited with the clustered + regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex + to disrupt expression of endogenous TCR and major histocompatibility complex + (MHC) class I molecules and modified to express a chimeric antigen receptor + (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation + antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), + with potential immunostimulating and antineoplastic activities. Upon introduction + into the patient, the allogeneic CRISPR-Cas9 engineered anti-BCMA CAR T-cells + CTX120 recognize and bind to BCMA-overexpressing tumor cells. This may result + in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of BCMA-positive + tumor cells. BCMA, a receptor for proliferation-inducing ligand (APRIL) and + B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) + receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. + BCMA is found on the surfaces of plasma cells and overexpressed on malignant + plasma cells. The disruption of endogenous TCR prevents graft-versus-host disease + (GvHD). The disruption of MHC class I molecules increases the persistence of + the CAR T-cells. + termDef: + term: >- + Allogeneic CRISPR-Cas9 Engineered Anti-BCMA T Cells CTX120 + source: NCIt + cde_id: C172741 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172741" + term_id: C172741 + term_version: 20.10d + +allogeneic_crisprcas9_engineered_anticd70_cart_cells_ctx130: + common: + description: >- + A preparation of human allogeneic T-lymphocytes gene-edited with the clustered + regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex + to disrupt expression of endogenous TCR and major histocompatibility complex + (MHC) class I molecules and modified to express a chimeric antigen receptor + (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation + 70 (CD70), with potential immunostimulating and antineoplastic activities. Upon + introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD70 + CAR T-cells CTX130 recognize and bind to CD70-overexpressing tumor cells. This + may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive + tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member + of the tumor necrosis factor (TNF) family, is found on the surfaces of various + types of cancer cells. Disruption of endogenous TCR prevents graft-versus-host + disease (GvHD); the disruption of MHC class I molecules increases the persistence + of the CAR T-cells. + termDef: + term: >- + Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130 + source: NCIt + cde_id: C173153 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173153" + term_id: C173153 + term_version: 20.10d + +allogeneic_cs1specific_universal_carexpressing_tlymphocytes_ucartcs1a: + common: + description: >- + A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like + effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically + modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated + antigen (TAA) human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; + CRACC), with potential immunomodulating and antineoplastic activities. Upon + transfusion of allogeneic CS1-specific universal CAR-expressing T-lymphocytes + UCARTCS1A, these cells target and bind to cancer cells expressing CS1. This + induces selective toxicity in and causes lysis of CS1-expressing tumor cells. + SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family + of transmembrane receptors that modulate the function of immune cells through + immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor + proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is + minimally expressed on healthy immune cells. + termDef: + term: >- + Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A + source: NCIt + cde_id: C165661 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165661" + term_id: C165661 + term_version: 20.10d + +allogeneic_plasmacytoid_dendritic_cells_expressing_lung_tumor_antigens_pdclung01: + common: + description: >- + An off-the-shelf (OTS) preparation composed of irradiated allogeneic plasmacytoid + dendritic cells (pDCs) loaded with seven immunogenic, human leukocyte antigen + (HLA)-A*02:01 serotype-restricted peptides derived from the lung tumor antigens + cancer/testis antigen 1 (NY-ESO-1), melanoma antigen A3 (MAGE-A3), MAGE-A4, + multi-MAGE, a peptide shared by multiple MAGE-A proteins, survivin, mucin1 (MUC1) + and melanoma antigen recognized by T-cells 1 (Mart-1; Melan-A), with potential + immunostimulating and antineoplastic activities. Upon administration of the + allogeneic pDCs expressing lung tumor antigens PDC*lung01, the pDCs may activate + the immune system to mount a specific cytotoxic T-lymphocyte (CTL) response + against HLA-A*0201 positive lung cancer cells expressing the TAAs NY-ESO-1, + MAGE-A3, MAGEA4, multi-MAGE, survivin, MUC1 and melan-A. The pDCs are derived + from a distinct subset of dendritic cells (DCs) with a plasma cell-like morphology + and express a characteristic set of surface markers and may increase the anti-tumor + immune responses. + termDef: + term: >- + Allogeneic Plasmacytoid Dendritic Cells Expressing Lung Tumor Antigens PDC*lung01 + source: NCIt + cde_id: C173427 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173427" + term_id: C173427 + term_version: 20.10d + +allogeneic_thirdparty_suicide_genetransduced_antihladpb10401_cd4_tcells_ctl_19: + common: + description: >- + A preparation of allogeneic, third-party, CD4+ T-lymphocytes that specifically + recognizes the human leukocyte antigen (HLA)-DPB1*0401 and transduced with a + suicide gene, with potential antineoplastic activity. Upon administration, allogeneic + third-party suicide gene-transduced anti-HLA-DPB1*0401 CD4+ T-cells CTL 19 specifically + target and kill HLA-DPB1*0401-positive leukemic cells. The suicide gene causes + the destruction of the T-cell clone upon the administration and presence of + ganciclovir, which enhances the safety of the agent. HLA-DP is expressed by + many leukemic cells. + termDef: + term: >- + Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T-cells + CTL 19 + source: NCIt + cde_id: C174401 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174401" + term_id: C174401 + term_version: 20.10d + +allosteric_erbb_inhibitor_bdtx189: + common: + description: >- + An orally bioavailable, irreversible, selective, small-molecule inhibitor of + certain oncogenic driver, allosteric mutations of the ErbB receptor tyrosine + kinases epidermal growth factor receptor (EGFR/ErbB1) and human epidermal growth + factor receptor 2 (HER2/neu or ErbB2), including extracellular domain allosteric + mutations of HER2, and EGFR and HER2 exon 20 insertion mutations, with potential + antineoplastic activity. Upon oral administration, the allosteric ErbB inhibitor + BDTX-189 selectively binds to and inhibits these allosteric ErbB mutants while + sparing wild-type EGFR, which may result in the selective inhibition of cellular + proliferation and angiogenesis in tumor cells and tumors expressing these allosteric + ErbB mutations. EGFR and HER2, ErbB receptor tyrosine kinases mutated or overexpressed + in many tumor cell types, play a key role in tumor cell proliferation and tumor + vascularization. + termDef: + term: >- + Allosteric ErbB Inhibitor BDTX-189 + source: NCIt + cde_id: C171059 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171059" + term_id: C171059 + term_version: 20.10d + +alobresib: + common: + description: >- + An orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) + family of proteins, with potential antineoplastic activity. Upon oral administration, + alobresib binds to the acetylated lysine recognition motifs in the bromodomains + of BET proteins, thereby preventing the interaction between the BET proteins + and acetylated histones. This disrupts chromatin remodeling and gene expression. + Prevention of the expression of certain growth-promoting genes may lead to an + inhibition of proliferation in BET-overexpressing tumor cells. BET proteins, + comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that + play an important role during development and cellular growth. + termDef: + term: >- + Alobresib + source: NCIt + cde_id: C126640 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126640" + term_id: C126640 + term_version: 20.10d + +alofanib: + common: + description: >- + An inhibitor of the fibroblast growth factor receptor (FGFR) type 2 (FGFR2), + with potential antineoplastic and anti-angiogenic activities. Upon administration, + alofanib targets, allosterically binds to the extracellular domain of FGFR2 + and inhibits the activity of FGFR2, which may result in the inhibition of basic + FGF (bFGF)/FGFR2-related signal transduction pathways. This inhibits FGF-induced + endothelial cell proliferation and migration, and inhibits the proliferation + of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated + in many tumor cell types, plays a key role in cellular proliferation, migration + and survival. + termDef: + term: >- + Alofanib + source: NCIt + cde_id: C170744 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170744" + term_id: C170744 + term_version: 20.10d + +alpha_cell_tumor_malignant: + common: + description: >- + A glucagon-producing neuroendocrine tumor arising from the alpha cells of the + pancreas. It may be associated with necrolytic erythema migrans, diarrhea, + diabetes, glossitis, weight loss, malabsorption, and anemia. It displays vascular + invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Pancreatic Glucagonoma + source: NCIt + cde_id: C65187 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65187" + term_id: C65187 + term_version: 20.05a + +alpha_fetoprotein: + common: + description: >- + The determination of the amount of alpha-fetoprotein present in a sample. + termDef: + term: >- + Alpha-fetoprotein Measurement + source: NCIt + cde_id: C74732 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74732" + term_id: C74732 + term_version: 20.10d + +alpha_heavy_chain_disease: + common: + description: >- + A clonal disorder, also known as immunoproliferative small intestinal disease + or Mediterranean lymphoma, characterised by the secretion of a defective alpha + heavy chain. It predominantly affects young people in the Mediterranean region. It + involves the small intestine, and patients usually present with malabsorption + syndrome, abdominal pain, weight loss, and fever. There is extensive villous + atrophy of the small intestinal mucosa, which is heavily infiltrated by small + lymphocytes and plasma cells. The small intestinal morphologic changes are + consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). + termDef: + term: >- + Alpha Heavy Chain Disease + source: NCIt + cde_id: C3132 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3132" + term_id: C3132 + term_version: 20.05a + +alpha_v_beta_8_antagonist_pf06940434: + common: + description: >- + An antagonist of integrin alpha v beta 8, with potential antineoplastic activity. + Upon administration, PF-06940434 selectively binds to and blocks the receptor + for integrin alpha v beta 8, thereby preventing integrin alpha v beta 8 binding. + This may result in the inhibition of cell adhesion in the tumor microenvironment + (TME) and blocks the activation of the cytokine transforming growth factor-beta + 1 (TGF-b1), preventing TGF-b1-mediated signal transduction. This abrogates TGF-b1-mediated + immunosuppression, enhances anti-tumor immunity in the TME and promotes a cytotoxic + T-lymphocyte (CTL)-mediated immune response against tumor cells leading to tumor + cell death. This may lead to a reduction in TGF-b1-dependent proliferation of + cancer cells. Alpha v beta 8 integrin plays a key role in tumor initiation, + growth, and progression through TGF-b1 activation. It is expressed in a variety + of tumor cell types and is associated with poor prognosis. + termDef: + term: >- + Alpha V Beta 8 Antagonist PF-06940434 + source: NCIt + cde_id: C172097 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172097" + term_id: C172097 + term_version: 20.10d + +alsevalimab: + common: + description: >- + A fully human, glycoengineered monoclonal antibody targeting B7-H4 (V-set domain-containing + T-cell activation inhibitor 1; VTCN1; B7x; B7S1) with potential antineoplastic + and immune checkpoint inhibitory activities. Upon intravenous administration, + alsevalimab binds to B7-H4 on the surface of tumor cells, thereby preventing + B7-H4 binding to T-cells and abrogating the B7-H4-mediated negative regulation + of T-cell activation. This increases a cytotoxic T-lymphocyte (CTL)-mediated + immune response against B7-H4-expressing tumor cells. In addition, the afucosylated + Fc region of the anti-B7-H4 monoclonal antibody FPA150 enhances its binding + affinity for human FcgammaRIIIa receptors (CD16) on natural killer (NK) cells, + resulting in enhanced antibody-dependent cellular cytotoxicity (ADCC) against + B7-H4-expressing tumor cells. B7-H4, a member of the B7 family of immune modulators, + is upregulated in a variety of tumor cell types and negatively regulates T-cell + immune responses. + termDef: + term: >- + Alsevalimab + source: NCIt + cde_id: C155967 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155967" + term_id: C155967 + term_version: 20.10d + +altered_mental_status: + common: + description: >- + A change to an individual's judgment, orientation (to place, time, and self), + intellectual functioning, or mood from their baseline. + termDef: + term: >- + Altered Mental Status + source: NCIt + cde_id: C121628 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121628" + term_id: C121628 + term_version: 20.05a + +alveolar_adenocarcinoma: + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +alveolar_adenoma: + common: + description: >- + A benign, well circumscribed lung neoplasm morphologically characterized by + the presence of cystic spaces resembling alveoli, lined by a simple cuboidal + epithelium. The cystic spaces are surrounded by a spindle cell stroma which + may show myxoid changes. It is a solitary, usually peripheral lung lesion. Patients + are usually asymptomatic and its discovery is an incidental finding during chest + X-ray examination. Surgical excision is curative. + termDef: + term: >- + Alveolar Adenoma + source: NCIt + cde_id: C4140 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4140" + term_id: C4140 + term_version: 20.05a + +alveolar_carcinoma: + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +alveolar_cell_carcinoma: + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +alveolar_rhabdomyosarcoma: + common: + description: >- + A rapidly growing malignant mesenchymal neoplasm. It is characterized by the + presence of round cells with myoblastic differentiation and a fibrovascular + stroma resembling an alveolar growth pattern. The tumor usually presents in + the extremities. + termDef: + term: >- + Alveolar Rhabdomyosarcoma + source: NCIt + cde_id: C3749 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3749" + term_id: C3749 + term_version: 20.05a + +alveolar_soft_part_sarcoma: + common: + description: >- + A rare malignant neoplasm characterized by the presence of large epithelioid + cells with abundant cytoplasm forming nests and pseudoalveolar structures. The + groups of the epithelioid cells are separated by thin-walled sinusoidal spaces. + It occurs most often in adolescents and young adults. In adults the most common + sites of involvement are the extremities, and in infants and children, the head + and neck. It usually presents as a slowly growing mass and it frequently metastasizes + to other anatomic sites. The most common sites of metastasis are the lungs, + bone, and brain. + termDef: + term: >- + Alveolar Soft Part Sarcoma + source: NCIt + cde_id: C3750 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3750" + term_id: C3750 + term_version: 20.05a + +amelanotic_melanoma: + common: + description: >- + A melanoma characterized by the complete absence of melanin pigment in the melanoma + cells. It occurs more frequently on the face and it is often associated with + desmoplastic reaction. + termDef: + term: >- + Amelanotic Melanoma + source: NCIt + cde_id: C3802 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3802" + term_id: C3802 + term_version: 20.05a + +ameloblastic_carcinoma: + common: + description: >- + A rare, cytologically malignant ameloblastoma that may metastasize. + termDef: + term: >- + Ameloblastic Carcinoma + source: NCIt + cde_id: C7492 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7492" + term_id: C7492 + term_version: 20.05a + +ameloblastic_fibrodentinoma: + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It usually arises from the + posterior mandible. It is characterized by the presence of an epithelial component, + fibromyxoid stroma, and dentin formation. It is treated with enucleation and + curettage. Recurrences may occur. + termDef: + term: >- + Ameloblastic Fibrodentinoma + source: NCIt + cde_id: C66800 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66800" + term_id: C66800 + term_version: 20.05a + +ameloblastic_fibroma: + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It usually arises from the + posterior mandible. It is characterized by the presence of an epithelial component + and fibromyxoid stroma. It may recur and rarely shows malignant transformation + to ameloblastic fibrosarcoma. It is treated with enucleation and curettage. + termDef: + term: >- + Ameloblastic Fibroma + source: NCIt + cde_id: C4316 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4316" + term_id: C4316 + term_version: 20.05a + +ameloblastic_fibroodontoma: + common: + description: >- + A rare benign neoplasm arising from tooth-forming tissues. It is characterized + by the presence of a fibromyxoid stroma, epithelial component, dentin, and enamel. + Recurrences are rare. + termDef: + term: >- + Ameloblastic Fibro-Odontoma + source: NCIt + cde_id: C3710 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3710" + term_id: C3710 + term_version: 20.05a + +ameloblastic_fibrosarcoma: + common: + description: >- + A locally aggressive malignant neoplasm arising from odontogenic tissue. It + occurs in the mandible and less often in the maxilla. It is characterized by + the presence of a malignant connective tissue component and a benign epithelial + component. The frequency of distal metastases is low. + termDef: + term: >- + Ameloblastic Fibrosarcoma + source: NCIt + cde_id: C4317 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4317" + term_id: C4317 + term_version: 20.05a + +ameloblastic_sarcoma: + common: + description: >- + A locally aggressive malignant neoplasm arising from odontogenic tissue. It + occurs in the mandible and less often in the maxilla. It is characterized by + the presence of a malignant connective tissue component and a benign epithelial + component. The frequency of distal metastases is low. + termDef: + term: >- + Ameloblastic Fibrosarcoma + source: NCIt + cde_id: C4317 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4317" + term_id: C4317 + term_version: 20.05a + +ameloblastoma_malignant: + common: + description: >- + A rare, well differentiated, cytologically benign ameloblastoma which paradoxically + metastasizes. + termDef: + term: >- + Metastasizing Ameloblastoma + source: NCIt + cde_id: C54297 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54297" + term_id: C54297 + term_version: 20.05a + +ameloblastoma_nos: + common: + description: >- + The most common odontogenic tumor, arising from the epithelial component of + the embryonic tooth and usually affecting the molar-ramus region of the mandible + or maxilla. Although most ameloblastomas are morphologically and clinically + benign, they may cause extensive local destruction, recur, or metastasize. + termDef: + term: >- + Ameloblastoma + source: NCIt + cde_id: C4313 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4313" + term_id: C4313 + term_version: 20.05a + +amer1: + common: + description: >- + This gene may play a role in kidney development. + termDef: + term: >- + AMER1 Gene + source: NCIt + cde_id: C68718 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68718" + term_id: C68718 + term_version: 20.10d + +american_indian_or_alaska_native: + common: + description: >- + A person having origins in any of the original peoples of North and South America + (including Central America) and who maintains tribal affiliation or community + attachment. (OMB) + termDef: + term: >- + American Indian or Alaska Native + source: NCIt + cde_id: C41259 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C41259" + term_id: C41259 + term_version: 19.12e + +amivantamab: + common: + description: >- + A human bispecific antibody targeting both epidermal growth factor receptor + EGFR and hepatocyte growth factor receptor (HGFR; cMet), with potential antineoplastic + activity. Upon administration, amivantamab simultaneously targets and binds + to wild-type or certain mutant forms of both EGFR and cMet expressed on cancer + cells, thereby preventing receptor phosphorylation. This prevents the activation + of both EGFR- and cMet-mediated signaling pathways. In addition, binding results + in receptor degradation, which further inhibits EGFR- and cMet-mediated signaling. + JNJ-61186372 also causes antibody-dependent cellular cytotoxicity (ADCC). Altogether, + this results in the inhibition of tumor cell proliferation. EGFR and cMet, both + upregulated or mutated in a variety of tumor cell types, play key roles in tumor + cell proliferation. + termDef: + term: >- + Amivantamab + source: NCIt + cde_id: C124993 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124993" + term_id: C124993 + term_version: 20.10d + +aml_m6: + common: + description: >- + An acute myeloid leukemia characterized by a predominant immature erythroid + population. There are two subtypes recognized: erythroleukemia and pure erythroid + leukemia. (WHO, 2001) + termDef: + term: >- + Acute Erythroid Leukemia + source: NCIt + cde_id: C8923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8923" + term_id: C8923 + term_version: 20.05a + +amplification: + common: + description: >- + An increase in the copy number of a particular gene. This type of abnormality + can be either inherited or somatic. + termDef: + term: >- + Gene Amplification Abnormality + source: NCIt + cde_id: C45581 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45581" + term_id: C45581 + term_version: 20.10d + +ampulla_of_vater: + common: + description: >- + The junction of the common bile and main pancreatic ducts, which protrudes into + the medial aspect of the descending duodenum at the major duodenal papilla. + The flow of bile and pancreatic juices into the duodenum through the Ampulla + of Vater is controlled by the sphincter of Oddi. + termDef: + term: >- + Ampulla of Vater + source: NCIt + cde_id: C13011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13011" + term_id: C13011 + term_version: 20.05a + +anal_canal: + common: + description: >- + The terminal section of the alimentary canal, which extends from the anorectal + junction and ends at the anal opening. + termDef: + term: >- + Anal Canal + source: NCIt + cde_id: C12375 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12375" + term_id: C12375 + term_version: 20.05a + +anal_intraepithelial_neoplasia_grade_iii: + common: + description: >- + Anal canal or perianal skin intraepithelial neoplasia with severe dysplasia. + termDef: + term: >- + Anal Intraepithelial Neoplasia 3 + source: NCIt + cde_id: C157575 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157575" + term_id: C157575 + term_version: 20.05a + +anaplastic_astrocytoma_idhmutant: + common: + description: >- + Anaplastic astrocytoma carrying IDH mutations. + termDef: + term: >- + Anaplastic Astrocytoma, IDH-Mutant + source: NCIt + cde_id: C129290 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129290" + term_id: C129290 + term_version: 20.05a + +anaplastic_astrocytoma_idhwildtype: + common: + description: >- + Anaplastic astrocytoma lacking mutations in IDH1 or IDH2 genes. + termDef: + term: >- + Anaplastic Astrocytoma, IDH-Wildtype + source: NCIt + cde_id: C129291 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129291" + term_id: C129291 + term_version: 20.05a + +anaplastic_large_bcell_lymphoma: + common: + description: >- + A diffuse large B-cell lymphoma variant characterized by the presence of large + round, oval, or polygonal cells with bizarre pleomorphic nuclei resembling Hodgkin + or Reed-Sternberg cells. It is unrelated to anaplastic large cell lymphoma which + is a T-cell non-Hodgkin lymphoma. + termDef: + term: >- + Anaplastic Lymphoma + source: NCIt + cde_id: C6916 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6916" + term_id: C6916 + term_version: 20.05a + +anaplastic_large_cell_lymphoma_alk_negative: + common: + description: >- + A T-cell peripheral lymphoma morphologically indistinguishable from anaplastic + large cell lymphoma, ALK-positive. It is characterized by the absence of the + translocation involving the ALK gene and lacks expression of ALK fusion protein. + termDef: + term: >- + Anaplastic Large Cell Lymphoma, ALK-Negative + source: NCIt + cde_id: C37194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37194" + term_id: C37194 + term_version: 20.05a + +anaplastic_large_cell_lymphoma_alk_positive: + common: + description: >- + A T-cell peripheral lymphoma composed of usually large, pleomorphic, CD30 positive + T-lymphocytes with abundant cytoplasm characterized by the presence of a translocation + involving the ALK gene and expression of ALK fusion protein. Most patients + present with peripheral and/or abdominal lymphadenopathy, and often have advanced + disease and extranodal involvement. + termDef: + term: >- + Anaplastic Large Cell Lymphoma, ALK-Positive + source: NCIt + cde_id: C37193 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37193" + term_id: C37193 + term_version: 20.05a + +anaplastic_large_cell_lymphoma_cd30: + common: + description: >- + A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, + CD30 positive cells. The majority of cases are positive for the anaplastic large + cell lymphoma (ALK) protein. The most frequently seen genetic alteration is + a t(2;5) translocation. Majority of patients present with advanced disease. + The most important prognostic indicator is ALK positivity, which has been associated + with a favorable prognosis. (WHO, 2001) + termDef: + term: >- + Anaplastic Large Cell Lymphoma + source: NCIt + cde_id: C3720 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3720" + term_id: C3720 + term_version: 20.05a + +anaplastic_large_cell_lymphoma_nos: + common: + description: >- + A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, + CD30 positive cells. The majority of cases are positive for the anaplastic large + cell lymphoma (ALK) protein. The most frequently seen genetic alteration is + a t(2;5) translocation. Majority of patients present with advanced disease. + The most important prognostic indicator is ALK positivity, which has been associated + with a favorable prognosis. (WHO, 2001) + termDef: + term: >- + Anaplastic Large Cell Lymphoma + source: NCIt + cde_id: C3720 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3720" + term_id: C3720 + term_version: 20.05a + +anaplastic_medulloblastoma: + common: + description: >- + A medulloblastoma characterized by marked nuclear pleomorphism, and high mitotic + activity. + termDef: + term: >- + Anaplastic Medulloblastoma + source: NCIt + cde_id: C92625 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92625" + term_id: C92625 + term_version: 20.05a + +anaplastic_oligoastrocytoma: + common: + description: >- + An oligoastrocytoma characterized by the presence of increased cellularity, + nuclear atypia, pleomorphism, and high mitotic activity. + termDef: + term: >- + Anaplastic Oligoastrocytoma + source: NCIt + cde_id: C6959 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6959" + term_id: C6959 + term_version: 20.05a + +anaplastic_oligodendroglioma_idhmutant_and_1p19qcodeleted: + common: + description: >- + An anaplastic oligodendroglioma carrying IDH gene family mutation and combined + whole-arm losses of 1p and 19q (1p/19q codeletion). + termDef: + term: >- + Anaplastic Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted + source: NCIt + cde_id: C129321 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129321" + term_id: C129321 + term_version: 20.05a + +anaplastic_pleomorphic_xanthroastrocytoma: + common: + description: >- + A WHO grade III pleomorphic xanthoastrocytoma characterized by the presence + of five or more mitoses per 10 high-power fields. Necrosis may be present. Patients + have shorter survival rates when compared to those with WHO grade II pleomorphic + xanthoastrocytoma. + termDef: + term: >- + Anaplastic Pleomorphic Xanthoastrocytoma + source: NCIt + cde_id: C129327 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129327" + term_id: C129327 + term_version: 20.05a + +ancient_schwannoma: + common: + description: >- + A schwannoma that is characterized by degenerative changes such as hyalinization, + hemorrhage, calcification and cystic change. + termDef: + term: >- + Degenerated Schwannoma + source: NCIt + cde_id: C6556 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6556" + term_id: C6556 + term_version: 20.05a + +andecaliximab: + common: + description: >- + A humanized monoclonal antibody against matrix metalloproteinase 9 (MMP-9), + with potential antineoplastic activity. Upon administration, andecaliximab binds + to MMP-9 and inhibits its enzymatic activity. This results in an inhibition + of extracellular matrix protein degradation and, potentially, the inhibition + of angiogenesis, tumor growth, invasion, and metastasis. MMP-9, a protein belonging + to the MMP family, plays a key role in the degradation of collagens and proteoglycans; + increased activity of MMP-9 has been associated with increased invasion and + metastasis of cancer. + termDef: + term: >- + Andecaliximab + source: NCIt + cde_id: C105803 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C105803" + term_id: C105803 + term_version: 20.10d + +andorra: + common: + description: >- + A country in southwestern Europe, between France and Spain. + termDef: + term: >- + Andorra + source: NCIt + cde_id: C16289 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16289" + term_id: C16289 + term_version: 19.12e + +androblastoma_benign: + common: + description: >- + A Sertoli cell tumor of the testis or the ovary which remains localized and + does not metastasize to another anatomic site. + termDef: + term: >- + Benign Sertoli Cell Tumor + source: NCIt + cde_id: C67012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67012" + term_id: C67012 + term_version: 20.05a + +androblastoma_malignant: + common: + description: >- + A Sertoli cell tumor that arises from the testis or the ovary. It is characterized + by nuclear pleomorphism, increased mitotic activity and necrotic changes. Metastases + may be present at diagnosis. + termDef: + term: >- + Malignant Sertoli Cell Tumor + source: NCIt + cde_id: C67006 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67006" + term_id: C67006 + term_version: 20.05a + +androblastoma_nos: + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +androgen_receptor_degrader_cc94676: + common: + description: >- + An orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic + activity. Upon administration, AR degrader CC-94676 causes degradation of AR, + prevents AR-mediated signaling and inhibits the proliferation of AR-overexpressing + tumor cells. AR plays a key role in tumor cell proliferation in castration-resistant + prostate cancer (CRPC). + termDef: + term: >- + Androgen Receptor Degrader CC-94676 + source: NCIt + cde_id: C173364 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173364" + term_id: C173364 + term_version: 20.10d + +androgen_receptor_inhibitor_epi7386: + common: + description: >- + An orally bioavailable, second-generation inhibitor of the N-terminal domain + (NTD) of androgen receptor (AR), with potential antineoplastic activity. Upon + oral administration, AR inhibitor EPI-7386 specifically binds to the NTD of + AR, thereby inhibiting both AR activation and the AR-mediated signaling pathway. + This may inhibit cell growth in AR-overexpressing tumor cells. AR is overexpressed + in prostate cancers and is involved in the proliferation, survival and chemoresistance + of tumor cells. EPI-7386 may be more active and metabolically stable than first-generation + AR NTD inhibitors. + termDef: + term: >- + Androgen Receptor Inhibitor EPI-7386 + source: NCIt + cde_id: C173374 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173374" + term_id: C173374 + term_version: 20.10d + +androgen_receptorglucocorticoid_receptor__antagonist_cb0310: + common: + description: >- + An orally bioavailable steroidal cortexolone derivative and antagonist of the + androgen receptor (AR) and glucocorticoid receptor (GR), with potential antineoplastic + activity. Upon oral administration, AR/GR antagonist CB-03-10 specifically binds + to AR and GR, inhibits AR and GR activation, and prevents AR- and GR-mediated + signaling. This leads to an induction of both extrinsic and intrinsic apoptotic + pathways and inhibits cell growth in AR- and GR-overexpressing tumor cells. + AR and GR are overexpressed in certain types of cancer cells and are involved + in proliferation, survival and chemoresistance of tumor cells. + termDef: + term: >- + Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10 + source: NCIt + cde_id: C172104 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172104" + term_id: C172104 + term_version: 20.10d + +aneuploid: + common: + description: >- + A chromosomal abnormality in which there is an addition or loss of chromosomes + within a set (e.g., 23 + 22 or 23 + 24). + termDef: + term: >- + Aneuploidy + source: NCIt + cde_id: C2873 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2873" + term_id: C2873 + term_version: 20.10d + +angioblastoma: + common: + description: >- + A WHO grade I tumor of uncertain histogenesis which is composed of stromal cells + and abundant capillaries. Approximately 25% of hemangioblastomas are associated + with Von Hippel-Lindau disease, a disease inherited through an autosomal dominant + trait and characterized by the development of hemangioblastomas of the central + nervous system and retina, clear cell renal carcinoma, pheochromocytoma, and + pancreatic and inner ear tumors. (Adapted from WHO) + termDef: + term: >- + Hemangioblastoma + source: NCIt + cde_id: C3801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3801" + term_id: C3801 + term_version: 20.05a + +angiocentric_glioma: + common: + description: >- + A WHO grade I, slow-growing brain neoplasm of children and young adults, associated + with epilepsy. Morphologically it is characterized by an angiocentric pattern, + monomorphic cellular infiltrate, and ependymal differentiation. + termDef: + term: >- + Angiocentric Glioma + source: NCIt + cde_id: C92552 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92552" + term_id: C92552 + term_version: 20.05a + +angiocentric_immunoproliferative_lesion: + common: + description: >- + A neoplastic lymphoproliferative process characterized by an angiocentric arrangement + of the tumor cells which is associated with angiodestruction. It includes lymphomatoid + granulomatosis which is a lymphoproliferative lesion derived from mature B-lymphocytes + and cases of extranodal NK/T-cell lymphomas of nasal type. + termDef: + term: >- + Angiocentric Immunoproliferative Lesion + source: NCIt + cde_id: C40970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40970" + term_id: C40970 + term_version: 20.05a + +angiocentric_tcell_lymphoma: + common: + description: >- + An aggressive, predominantly extranodal, mature T-cell non-Hodgkin lymphoma. + It is characterized by an often angiocentric and angiodestructive cellular infiltrate + composed of EBV positive NK/T cells. The nasal cavity is the most common site + of involvement. Patients often present with midfacial destructive lesions (lethal + midline granuloma). The disease may disseminate rapidly to various anatomic + sites including the gastrointestinal tract, skin, testis, and cervical lymph + nodes. It is also known as angiocentric T-cell lymphoma. The term "polymorphic + reticulosis" has been widely used to describe the morphologic changes seen in + this type of lymphoma. However, the latter term may also apply to lymphomatoid + granulomatosis, which is an angiocentric and angiodestructive EBV positive B-cell + lymphoproliferative disorder. + termDef: + term: >- + Nasal Type Extranodal NK/T-Cell Lymphoma + source: NCIt + cde_id: C4684 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4684" + term_id: C4684 + term_version: 20.05a + +angioendothelioma: + common: + description: >- + A vascular proliferation characterized by the presence of prominent endothelial + cells and the formation of vascular channels. Hemangioendotheliomas may display + borderline or low grade characteristics. + termDef: + term: >- + Hemangioendothelioma + source: NCIt + cde_id: C3084 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3084" + term_id: C3084 + term_version: 20.05a + +angioendotheliomatosis: + common: + description: >- + A rare extranodal B-cell non-Hodgkin lymphoma, characterized by the presence + of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries. This + is an extremely aggressive lymphoma which responds poorly to chemotherapy. (WHO, + 2001) + termDef: + term: >- + Intravascular Large B-Cell Lymphoma + source: NCIt + cde_id: C4342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4342" + term_id: C4342 + term_version: 20.05a + +angiofibroma_nos: + common: + description: >- + A morphologic variant of fibroma characterized by the presence of numerous dilated + vascular channels. + termDef: + term: >- + Angiofibroma + source: NCIt + cde_id: C3799 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3799" + term_id: C3799 + term_version: 20.05a + +angioimmunoblastic_lymphadenopathy: + common: + description: >- + A peripheral T-cell lymphoma of mature T follicular helper (TFH) cells characterized + by systemic disease and a polymorphous infiltrate involving lymph nodes, with + a prominent proliferation of high endothelial venules and follicular dendritic + cells. EBV-positive cells are nearly always present. It is a clinically aggressive + lymphoma and seen mainly in older adults. (WHO 2017) + termDef: + term: >- + Angioimmunoblastic T-Cell Lymphoma + source: NCIt + cde_id: C7528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7528" + term_id: C7528 + term_version: 20.05a + +angioimmunoblastic_lymphoma: + common: + description: >- + A peripheral T-cell lymphoma of mature T follicular helper (TFH) cells characterized + by systemic disease and a polymorphous infiltrate involving lymph nodes, with + a prominent proliferation of high endothelial venules and follicular dendritic + cells. EBV-positive cells are nearly always present. It is a clinically aggressive + lymphoma and seen mainly in older adults. (WHO 2017) + termDef: + term: >- + Angioimmunoblastic T-Cell Lymphoma + source: NCIt + cde_id: C7528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7528" + term_id: C7528 + term_version: 20.05a + +angioimmunoblastic_tcell_lymphoma: + common: + description: >- + A peripheral T-cell lymphoma of mature T follicular helper (TFH) cells characterized + by systemic disease and a polymorphous infiltrate involving lymph nodes, with + a prominent proliferation of high endothelial venules and follicular dendritic + cells. EBV-positive cells are nearly always present. It is a clinically aggressive + lymphoma and seen mainly in older adults. (WHO 2017) + termDef: + term: >- + Angioimmunoblastic T-Cell Lymphoma + source: NCIt + cde_id: C7528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7528" + term_id: C7528 + term_version: 20.05a + +angiokeratoma: + common: + description: >- + A vascular lesion in the papillary dermis resulting from ectasia of pre-existing + vessels. It is associated with secondary proliferative changes in the overlying + epidermis (hyperkeratosis). It can present with widespread lesions (angiokeratoma + corporis diffusum, often associated with inborn errors of metabolism) or as + a localized lesion (angiokeratoma of Fordyce, angiokeratoma circumscriptum, + and angiokeratoma of Mibelli). + termDef: + term: >- + Angiokeratoma + source: NCIt + cde_id: C2874 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2874" + term_id: C2874 + term_version: 20.05a + +angioleiomyoma: + common: + description: >- + A benign, slow-growing neoplasm that arises from the dermis or subcutaneous + tissue. It is characterized by the presence of well-differentiated smooth muscle + cells which are arranged around numerous vessels. + termDef: + term: >- + Angioleiomyoma + source: NCIt + cde_id: C3747 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3747" + term_id: C3747 + term_version: 20.05a + +angiolipoma_nos: + common: + description: >- + A lipoma with prominent vascularity. The vascular tissue is more abundant at + the periphery of the tumor and contains fibrin thrombi. It occurs more frequently + in younger individuals as a painful subcutaneous nodule, often on the arms. + termDef: + term: >- + Angiolipoma + source: NCIt + cde_id: C3733 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3733" + term_id: C3733 + term_version: 20.05a + +angioma_nos: + common: + description: >- + A benign vascular lesion characterized by the formation of capillary-sized or + cavernous vascular channels. + termDef: + term: >- + Hemangioma + source: NCIt + cde_id: C3085 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3085" + term_id: C3085 + term_version: 20.05a + +angiomatoid_fibrous_histiocytoma: + common: + description: >- + A low malignant potential soft tissue neoplasm of uncertain differentiation. It + typically affects young patients, presenting as a slowly growing nodular or + cystic tumor mass, most often in the subcutaneous tissues of the extremities. Occasionally, + patients have systemic symptoms (anemia, fever, and weight loss). This tumor + has a relatively good prognosis. A minority of patients develop local recurrences. Metastases + are rare. + termDef: + term: >- + Angiomatoid Fibrous Histiocytoma + source: NCIt + cde_id: C6494 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6494" + term_id: C6494 + term_version: 20.05a + +angiomatous_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of small and medium sized + vessels that predominate over the meningioma cells. + termDef: + term: >- + Angiomatous Meningioma + source: NCIt + cde_id: C4332 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4332" + term_id: C4332 + term_version: 20.05a + +angiomyofibroblastoma: + common: + description: >- + A benign myofibroblastic neoplasm, usually arising in the pelviperineal region. + It is characterized by the presence of neoplastic spindle to round cells, dilated + thin walled vessels, and stromal edema. Most patients present with painless + circumscribed masses. + termDef: + term: >- + Angiomyofibroblastoma + source: NCIt + cde_id: C49016 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49016" + term_id: C49016 + term_version: 20.05a + +angiomyolipoma: + common: + description: >- + A neoplasm with perivascular epithelioid cell differentiation often associated + with tuberous sclerosis. It is characterized by a mixture of epithelioid cells, + smooth muscle, vessels, and mature adipose tissue. The kidney is the most common + site of involvement. Other sites of involvement include the liver, lung, lymph + nodes, and retroperitoneum. The vast majority of cases follow a benign clinical + course. However, cases of metastatic angiomyolipomas with sarcomatoid features + have been described. + termDef: + term: >- + Angiomyolipoma + source: NCIt + cde_id: C3734 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3734" + term_id: C3734 + term_version: 20.05a + +angiomyoma: + common: + description: >- + A benign, slow-growing neoplasm that arises from the dermis or subcutaneous + tissue. It is characterized by the presence of well-differentiated smooth muscle + cells which are arranged around numerous vessels. + termDef: + term: >- + Angioleiomyoma + source: NCIt + cde_id: C3747 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3747" + term_id: C3747 + term_version: 20.05a + +angiomyosarcoma: + common: + description: >- + A malignant smooth muscle neoplasm characterized by the presence of atypical + spindle cells and formation of vascular channels. + termDef: + term: >- + Angiomyosarcoma + source: NCIt + cde_id: C66771 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66771" + term_id: C66771 + term_version: 20.05a + +angiomyxoma: + common: + description: >- + A benign soft tissue neoplasm characterized by the presence of neoplastic spindle + and stellate cells in a myxoid stroma. + termDef: + term: >- + Angiomyxoma + source: NCIt + cde_id: C3254 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3254" + term_id: C3254 + term_version: 20.05a + +angiosarcoma: + common: + description: >- + A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, + it is characterized by frequently open vascular anastomosing and branching channels. The + malignant cells that line the vascular channels are spindle or epithelioid and + often display hyperchromatic nuclei. Angiosarcomas most frequently occur in + the skin and breast. Patients with long-standing lymphedema are at increased + risk of developing angiosarcoma. + termDef: + term: >- + Angiosarcoma + source: NCIt + cde_id: C3088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3088" + term_id: C3088 + term_version: 20.05a + +angiotropic_lymphoma: + common: + description: >- + A rare extranodal B-cell non-Hodgkin lymphoma, characterized by the presence + of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries. This + is an extremely aggressive lymphoma which responds poorly to chemotherapy. (WHO, + 2001) + termDef: + term: >- + Intravascular Large B-Cell Lymphoma + source: NCIt + cde_id: C4342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4342" + term_id: C4342 + term_version: 20.05a + +angola: + common: + description: >- + A country in southern Africa, bordering the South Atlantic Ocean, between Namibia + and Democratic Republic of the Congo. + termDef: + term: >- + Angola + source: NCIt + cde_id: C16292 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16292" + term_id: C16292 + term_version: 19.12e + +anguilla: + common: + description: >- + A group of islands in the Caribbean Sea, east of the Virgin Islands and north + of Saint Kitts and Nevis. + termDef: + term: >- + Anguilla + source: NCIt + cde_id: C20133 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20133" + term_id: C20133 + term_version: 19.12e + +anhydrous_enoloxaloacetate: + common: + description: >- + The anhydrous form of enol-oxaloacetate, a small molecule blood glutamate scavenger, + that can be used to lower glutamate plasma levels, and has potential neuroprotective + activity. Upon administration, enol-oxaloacetate targets and binds to glutamate + in the bloodstream. This lowers glutamate plasma levels and lowers the free + glutamate available to be picked up by cells, such as tumor brain cells, thereby + preventing glutamate metabolism and glutamate-mediated signaling. This prevents + the proliferation of rapidly growing cells, such as brain tumor cells. And by + lowering glutamate plasma levels, a molecular imbalance is formed and glutamate + is excreted across the blood-brain barrier, resulting in lower free brain glutamate. This + may help protect the brain from excitotoxicity in conditions where there is + a surge of glutamate production, such as traumatic brain injury, thereby protecting + neuronal cells. Glutamate, a non-essential amino acid and the major excitatory + neurotransmitter in the central nervous system (CNS), provides energy and generates + building blocks for the production of macromolecules, which are needed for cellular + growth and survival. + termDef: + term: >- + Anhydrous Enol-oxaloacetate + source: NCIt + cde_id: C168687 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168687" + term_id: C168687 + term_version: 20.10d + +ank1: + common: + description: >- + This gene plays a role in red blood cell morphology. + termDef: + term: >- + ANK1 Gene + source: NCIt + cde_id: C84301 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84301" + term_id: C84301 + term_version: 20.10d + +anterior_mediastinum: + common: + description: >- + The area between the lungs; it contains the thymus, some lymph nodes, and vessels + and branches of the internal thoracic artery. + termDef: + term: >- + Anterior Mediastinum + source: NCIt + cde_id: C32098 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32098" + term_id: C32098 + term_version: 20.05a + +anterior_surface_of_epiglottis: + common: + description: >- + The lingual or upper surface of the epiglottis. + termDef: + term: >- + Anterior Surface of the Epiglottis + source: NCIt + cde_id: C12238 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12238" + term_id: C12238 + term_version: 20.05a + +anterior_wall_of_bladder: + common: + description: >- + The anterior aspect of the bladder wall. + termDef: + term: >- + Anterior Wall of the Bladder + source: NCIt + cde_id: C12334 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12334" + term_id: C12334 + term_version: 20.05a + +anterior_wall_of_nasopharynx: + common: + description: >- + The anterior aspect of the nasopharynx. + termDef: + term: >- + Anterior Wall of the Nasopharynx + source: NCIt + cde_id: C12245 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12245" + term_id: C12245 + term_version: 20.05a + +anti5t4_antibodydrug_conjugate_asn004: + common: + description: >- + An antibody-drug conjugate (ADC) composed of an antibody directed against 5T4 + and conjugated, via a non-cleavable linker, to a proprietary polymer carrying + multiple auristatin analog molecules via a cleavable linker, with potential + antineoplastic activity. Upon administration, the antibody moiety of ASN004 + selectively binds to cells expressing the 5T4 oncofetal antigen. After internalization + and cleavage within the tumor cell cytosol, free auristatin analog molecules + binds to tubulin and inhibits its polymerization, which may result in G2/M phase + arrest and tumor cell apoptosis. 5T4, a transmembrane glycoprotein, is overexpressed + by a variety of cancer cell types; its expression is correlated with increased + invasiveness. + termDef: + term: >- + Anti-5T4 Antibody-drug Conjugate ASN004 + source: NCIt + cde_id: C173556 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173556" + term_id: C173556 + term_version: 20.10d + +anti5t4_antibodydrug_conjugate_syd1875: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) + monoclonal antibody directed against the oncofetal antigen 5T4 and site-specifically + conjugated to a duocarmycin-based linker-drug valine-citrulline-seco-DUocarmycin-hydroxyBenzamide-Azaindole + (vc-seco-DUBA), with potential antineoplastic activity. Upon administration, + the antibody moiety of SYD1875 selectively binds to cells expressing the 5T4 + oncofetal antigen. After internalization and cleavage within the tumor cell + by proteases, the free and activated duocarmycin payload binds to the minor + groove of DNA and alkylates adenine at the N3 position, which eventually leads + to tumor cell apoptosis. 5T4, a transmembrane glycoprotein, is overexpressed + by a variety of cancer cell types; its expression is correlated with increased + invasiveness. + termDef: + term: >- + Anti-5T4 Antibody-drug Conjugate SYD1875 + source: NCIt + cde_id: C175444 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175444" + term_id: C175444 + term_version: 20.10d + +antib7h3dxd_antibodydrug_conjugate_ds7300a: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody + against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) conjugated, + via an enzymatically cleavable tetrapeptide-based linker, to the cytotoxic DNA + topoisomerase I inhibitor and exatecan (DX-8951) derivative DXd (MAAA-1181a; + MAAA-1181), with potential antineoplastic activity. Upon administration of the + anti-B7-H3/DXd ADC DS-7300a, the anti-B7-H3 antibody targets and binds to B7-H3-expressing + tumor cells. Upon cellular uptake and lysosomal degradation of the linker, DXd + targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable + complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition + of DNA replication and apoptosis. This inhibits the proliferation of B7-H3-expressing + tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory + protein superfamily, is overexpressed on certain tumor cell types and on various + immune cells. It plays a key role in tumor growth and immune responses. The + ADC allows for reduced systemic exposure and enhanced delivery of the cytotoxic + agent DXd. + termDef: + term: >- + Anti-B7-H3/DXd Antibody-drug Conjugate DS-7300a + source: NCIt + cde_id: C171577 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171577" + term_id: C171577 + term_version: 20.10d + +antibcma_antibodydrug_conjugate_cc99712: + common: + description: >- + An antibody-drug conjugate (ADC) consisting of a monoclonal antibody against + the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA, TNFRSF17), + linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic + activity. Upon administration of anti-BCMA ADC CC-99712, the antibody moiety + targets and binds to the cell surface antigen BCMA expressed on certain cancer + cells. Upon binding and internalization, the cytotoxic agent is released and + kills the BCMA-expressing cancer cells through an as of yet unknown mechanism + of action. BCMA, a receptor for a proliferation-inducing ligand (APRIL; tumor + necrosis factor ligand superfamily member 13; TNFSF13), and B-cell activating + factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily + and plays a key role in plasma survival. It is found on the surfaces of plasma + cells and is overexpressed on malignant plasma cells. + termDef: + term: >- + Anti-BCMA Antibody-drug Conjugate CC-99712 + source: NCIt + cde_id: C170915 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170915" + term_id: C170915 + term_version: 20.10d + +antibcma_sparx_protein_plus_bcmadirected_antitaag_arc_tcells_cartddbcma: + common: + description: >- + An immunotherapeutic combination agent composed of antigen receptor complex + T cells (ARC-T cells) which contain a proprietary binding domain specific for + a universal TAG instead of a single chain variable fragment (scFv) binding domain, + and a tumor-targeting antigen protein, soluble protein antigen-receptor X-linker + (sparX) protein, containing a TAG moiety fused to two B-cell maturation antigen + (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) binding + domains, with potential antineoplastic activities. Upon administration of the + anti-BCMA sparX protein plus BCMA-directed ARC T-cells CART-ddBCMA, the sparX + protein, with its two BCMA binding domains, specifically targets and binds to + two BCMA expressed on tumor cells. In turn, the ARC-T cells, with their anti-TAG + domain, target and bind to the TAG domain on the sparX protein. This directly + links the ARC-T cells to the BCMA-expressing tumor cells, through the ARC-T + cell- sparX -tumor cell complex formation, thereby causing direct tumor cell + killing. BCMA, a tumor-associated antigen (TAA), is found on the surfaces of + plasma cells and is overexpressed on a variety of tumor cell types. Compared + to anti-BCMA CAR-T cells, CART-ddBCMA, containing ARC-T cells that are re-programmed + in vivo by the TAG sparX protein, shows enhanced efficiency and an improved + safety profile. As ARC-T activity is dependent on the sparX dose administered, + the rate of tumor cell killing, and related toxicities are also dependent on + the sparX dose administered. + termDef: + term: >- + Anti-BCMA SparX Protein Plus BCMA-directed Anti-TAAG ARC T-cells CART-ddBCMA + source: NCIt + cde_id: C167337 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167337" + term_id: C167337 + term_version: 20.10d + +antibcmaanticd3_bispecific_antibody_regn5459: + common: + description: >- + A human bispecific antibody directed against the tumor-associated antigen (TAA) + human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily + member 17; TNFRSF17) and another directed against the T-cell surface antigen + CD3, with potential immunostimulating and antineoplastic activities. Upon administration, + anti-BCMA/anti-CD3 bispecific antibody REGN5459 binds to both CD3 on cytotoxic + T-lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates + and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing + of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor + receptor superfamily that is specifically overexpressed on malignant plasma + cells, plays a key role in promoting plasma cell survival. + termDef: + term: >- + Anti-BCMA/Anti-CD3 Bispecific Antibody REGN5459 + source: NCIt + cde_id: C165656 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165656" + term_id: C165656 + term_version: 20.10d + +antibtla_monoclonal_antibody_tab004: + common: + description: >- + A recombinant humanized immunoglobulin G4 kappa (IgG4k) monoclonal antibody + directed against B- and T-lymphocyte attenuator (BTLA), with potential immunomodulating + and antineoplastic activities. Upon intravenous infusion administration, anti-BTLA + monoclonal antibody TAB004 targets and binds to BTLA. This prevents BTLA-mediated + inhibition of T-cell activation leading to antigen specific T-cell proliferation + and activation of a cytotoxic T-lymphocyte (CTL)-mediated immune response against + tumor cells. BTLA, an immunoglobulin (Ig) receptor family member expressed on + activated T- and B- lymphocytes, subsets of dendritic cells (DCs), macrophages, + and nature killer (NK) cells, is an immune checkpoint involved in suppressing + immune responses. It mediates inhibition of human tumor-specific CTLs upon engagement + by tumor expressed herpesvirus-entry mediator (HVEM). + termDef: + term: >- + Anti-BTLA Monoclonal Antibody TAB004 + source: NCIt + cde_id: C168617 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168617" + term_id: C168617 + term_version: 20.10d + +antibtn3a_agonistic_monoclonal_antibody_ict01: + common: + description: >- + A humanized agonistic monoclonal antibody directed against butyrophilin subfamily + 3 member A (BTN3A; CD277), with potential immunomodulating and antineoplastic + activities. Upon administration, the anti-BTN3A agonistic monoclonal antibody + ICT01 targets and binds to BTN3A present on epithelial and tumor cells. BTN3A + binding may sensitize tumor cells to gamma 9 delta 2 (Vg9Vd2) T cell killing. + The Vg9Vd2 T cells secrete effector cytokines and exert a cytolytic effect on + tumor cells. This may abrogate BTN3A-mediated tumor immunity and may enhance + anti-tumor immune response. BTN3A, a member of the butyrophilin superfamily + of immunomodulators, is upregulated in tumor cells. + termDef: + term: >- + Anti-BTN3A Agonistic Monoclonal Antibody ICT01 + source: NCIt + cde_id: C175508 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175508" + term_id: C175508 + term_version: 20.10d + +anticcr7_antibodydrug_conjugate_jbh492: + common: + description: >- + An antibody-drug conjugate (ADC) composed of an antibody targeting CC chemokine + receptor 7 (CCR7) and conjugated to the cytotoxic maytansinoid DM4, with potential + antineoplastic activity. Upon administration of anti-CCR7 ADC JBH492, the antibody + moiety targets and binds to CCR7 on tumor cells. Upon antibody/antigen binding + and internalization, the ADC releases DM4, which binds to tubulin and disrupts + microtubule assembly/disassembly dynamics. This results in the inhibition of + cell division and cell growth of CCR7-expressing tumor cells. CCR7, a G-protein + coupled receptor, is normally expressed by subsets of immune cells and overexpressed + by various types of cancer cells. Its overexpression has been associated with + lymph node metastasis and poor survival. + termDef: + term: >- + Anti-CCR7 Antibody-drug Conjugate JBH492 + source: NCIt + cde_id: C175477 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175477" + term_id: C175477 + term_version: 20.10d + +anticd117_monoclonal_antibody_jsp191: + common: + description: >- + A humanized monoclonal antibody directed against CD117 (tyrosine-protein kinase + KIT; c-Kit; mast/stem cell growth factor receptor; SCFR), that can potentially + be used to deplete hematopoietic stem cells (HSCs). Upon administration, the + anti-CD117 monoclonal antibody JSP191 targets and binds to CD117. This prevents + the binding of stem cell factor (SCF) to its receptor CD117 on HSCs. As CD117 + binding to SCF is critical for survival and maintenance of blood forming stem + cells, blocking this interaction causes the HSCs that are present in the bone + marrow niches to be depleted. JSP191 can potentially be used as a conditioning + regimen to prepare patients for hematopoietic stem cell transplantation. + termDef: + term: >- + Anti-CD117 Monoclonal Antibody JSP191 + source: NCIt + cde_id: C174050 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174050" + term_id: C174050 + term_version: 20.10d + +anticd137_agonistic_monoclonal_antibody_agen2373: + common: + description: >- + A conditionally-active, fully human immunoglobulin G1 (IgG1) agonistic monoclonal + antibody targeting the costimulatory receptor CD137 (4-1BB; tumor necrosis factor + receptor superfamily member 9; TNFRSF9), with potential immunostimulating and + antineoplastic activities. Upon administration, anti-CD137 agonistic monoclonal + antibody AGEN2373 targets and binds to a non-ligand blocking epitope on CD137, + thereby activating CD137 expressed on a variety of leukocyte subsets including + activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated + signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production + and promotes a CTL-mediated anti-tumor immune response as well as induces NK-mediated + tumor cell killing and suppresses the immunosuppressive activity of T-regulatory + cells (Tregs). CD137, a surface glycoprotein of the tumor necrosis factor receptor + superfamily, is an inducible costimulatory receptor that plays a key role in + T-cell proliferation, survival and cytolytic activity. In addition, as AGEN2373 + engages with CD137 only in the presence of CD137 ligand and/or Fc gamma receptor-expressing + antigen-presenting cells (APCs), this agent may have a decreased toxicity profile + and improved tolerability compared to other agents that activate CD137 signaling + beyond the tumor site in humans. + termDef: + term: >- + Anti-CD137 Agonistic Monoclonal Antibody AGEN2373 + source: NCIt + cde_id: C168522 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168522" + term_id: C168522 + term_version: 20.10d + +anticd137_agonistic_monoclonal_antibody_ator1017: + common: + description: >- + A humanized agonistic immunoglobulin G4 (IgG4) monoclonal antibody targeting + the costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily + member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. + Upon administration, anti-CD137 agonistic monoclonal antibody ATOR-1017 targets + and binds to CD137 expressed on a variety of leukocyte subsets including activated + T-lymphocytes and natural killer (NK) cells, and CD137 is activated upon crosslinking + to Fc-gamma receptors (FcgRs) on macrophages. This enhances CD137-mediated signaling, + induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and + promotes a CTL-mediated anti-tumor immune response as well as induces NK-mediated + tumor cell killing and suppresses the immunosuppressive activity of T-regulatory + cells (Tregs). CD137, a surface glycoprotein of the tumor necrosis factor receptor + superfamily, is an inducible costimulatory receptor that plays a key role in + T-cell proliferation, survival and cytolytic activity. 4-1BB and FcgRs are both + highly expressed in the tumor environment (TME) while their co-expression in + non-tumor tissues is low. This may prevent systemic adverse effects. + termDef: + term: >- + Anti-CD137 Agonistic Monoclonal Antibody ATOR-1017 + source: NCIt + cde_id: C173548 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173548" + term_id: C173548 + term_version: 20.10d + +anticd137_agonistic_monoclonal_antibody_lvgn6051: + common: + description: >- + A humanized agonistic monoclonal antibody targeting the costimulatory receptor + CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), + with potential immunostimulating and antineoplastic activities. Upon administration, + anti-CD137 agonistic monoclonal antibody LVGN6051 targets and binds to CD137, + thereby activating CD137 expressed on a variety of leukocyte subsets including + activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated + signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production + and promotes a CTL-mediated anti-tumor immune response as well as induces NK-mediated + tumor cell killing and suppresses the immunosuppressive activity of T-regulatory + cells (Tregs). CD137, a surface glycoprotein of the tumor necrosis factor receptor + superfamily, is an inducible costimulatory receptor that plays a key role in + T-cell proliferation, survival and cytolytic activity. + termDef: + term: >- + Anti-CD137 Agonistic Monoclonal Antibody LVGN6051 + source: NCIt + cde_id: C171541 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171541" + term_id: C171541 + term_version: 20.10d + +anticd19_antibodytcell_receptorexpressing_tcells_et019003: + common: + description: >- + A preparation of T-lymphocytes that have been engineered by incorporating an + as of yet undisclosed co-stimulatory molecule into T-cells expressing an anti-CD19 + antibody T-cell receptor (AbTCR) structure (ET190L1), with potential immunostimulating + and antineoplastic activities. Upon administration, anti-CD19 AbTCR-expressing + T-cells ET019003 targets and binds to CD19-expressing tumor cells. This results + in cytotoxic T-lymphocyte (CTL)-mediated elimination of CD19-positive tumor + cells. The binding to CD19-expressing tumor cells may also activate the undisclosed + costimulatory domain, leading to further T-cell proliferation. CD19 antigen + is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. + ET019003 is able to match the anticancer activity of chimeric antigen receptor + (CAR) T-cells, while they are less likely to stimulate cytokine release syndrome + (CRS) and less likely to cause cytokine-related toxicities. + termDef: + term: >- + Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003 + source: NCIt + cde_id: C172202 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172202" + term_id: C172202 + term_version: 20.10d + +anticd19_icar_nk_cells: + common: + description: >- + A preparation of natural killer (NK) cells engineered to express an inhibitory + chimeric antigen receptor (iCAR) specific for the tumor-associated antigen (TAA) + cluster of differentiation 19 (CD19), with potential immunostimulating and antineoplastic + activities. Upon administration, anti-CD19 iCAR-NK cells recognize, bind to + and induce selective cytotoxicity in CD19-expressing tumor cells. The iCAR is + designed to spare normal cells from NK cell actions by including an inhibitory + receptor that is activated upon binding to antigens that are present on normal + cells only. CD19 antigen is a B-cell specific cell surface antigen expressed + in all B-cell lineage malignancies. + termDef: + term: >- + Anti-CD19 iCAR NK Cells + source: NCIt + cde_id: C170903 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170903" + term_id: C170903 + term_version: 20.10d + +anticd19cd22_car_nk_cells: + common: + description: >- + A preparation of natural killer (NK) cells engineered to express a chimeric + antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster + of differentiation 19 (CD19) and CD22, with potential immunostimulating and + antineoplastic activities. Upon administration, the anti-CD19/CD22 CAR-NK cells + target and bind to CD19 and CD22 expressed on the surface of tumor cells. This + induces selective toxicity in tumor cells expressing these TAAs. CD19 and CD22, + both transmembrane phosphoglycoproteins expressed on the surface of cells in + the B lineage, are often overexpressed on malignant B-cells. By simultaneously + targeting two B-cell antigens, this preparation may minimize relapse due to + single antigen loss in patients with B-cell malignancies. + termDef: + term: >- + Anti-CD19/CD22 CAR NK Cells + source: NCIt + cde_id: C170904 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170904" + term_id: C170904 + term_version: 20.10d + +anticd20_monoclonal_antibody_bat4306f: + common: + description: >- + A recombinant, glycosylation-modified monoclonal antibody directed against the + human B-cell-specific cell surface antigen CD20, with potential antineoplastic + and immunomodulating activities. Upon administration of anti-CD20 monoclonal + antibody BAT4306F, the antibody specifically targets and binds to CD20. This + induces antibody-dependent cell-mediated cytotoxicity (ADCC) against CD20-expressing + B-cells, which leads to B-cell apoptosis and the inhibition of tumor cell proliferation. + CD20, a non-glycosylated cell surface phosphoprotein that is exclusively expressed + on B-cells during most stages of B-cell development, is often overexpressed + in B-cell malignancies. The complete defucosylation of BAT4306F may result in + enhanced ADCC. + termDef: + term: >- + Anti-CD20 Monoclonal Antibody BAT4306F + source: NCIt + cde_id: C173955 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173955" + term_id: C173955 + term_version: 20.10d + +anticd20_monoclonal_antibody_mil62: + common: + description: >- + A glyco-engineered recombinant humanized monoclonal antibody directed against + the human B-cell-specific cell surface antigen CD20, with potential antineoplastic + and immunomodulating activities. Upon administration of anti-CD20 monoclonal + antibody MIL62, the antibody specifically targets and binds to CD20. This induces + antibody-dependent cell-mediated cytotoxicity (ADCC) against CD20-expressing + B-cells, which leads to B-cell apoptosis and the inhibition of tumor cell proliferation. + In addition, MIL62 inhibits CD20-mediated signaling which further induces apoptosis + in and inhibits proliferation of CD20-expressing tumor cells. CD20, a non-glycosylated + cell surface phosphoprotein that is exclusively expressed on B-cells during + most stages of B-cell development, is often overexpressed in B-cell malignancies. + termDef: + term: >- + Anti-CD20 Monoclonal Antibody MIL62 + source: NCIt + cde_id: C166140 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166140" + term_id: C166140 + term_version: 20.10d + +anticd205_antibodydrug_conjugate_obt076: + common: + description: >- + An antibody-drug conjugate (ADC) comprised of an anti-CD205 (lymphocyte antigen + 75; Ly75) humanized immunoglobin G1 (IgG1) monoclonal antibody conjugated to + DM4, a maytansinoid microtubule disruptor, via a cleavable N-succinimidyl-4-(2-pyridyldithio) + butanoate (SPDB) linker, with potential antineoplastic activity. Upon intravenous + administration, anti-CD205 ADC OBT076 specifically targets and binds to CD205, + a receptor involved in antigen capture and endocytosis, expressed on tumor cells. + Following rapid internalization of the ADC/CD205 complex, OBT076 releases its + DM4 payload due to cleavage of the SPDB linker by intracellular proteases. Then + the DM4 binds to tubulin and disrupts microtubule assembly/disassembly dynamics, + resulting in the inhibition of both cell division and cell growth of CD205-expressing + tumor cells. CD205, a type I transmembrane surface glycoprotein belonging to + the C-type lectin receptor family, is normally expressed on various antigen-presenting + cells (APCs) and some leukocyte sub-populations but it is overexpressed in multiple + cancer types where it plays a key role in facilitating metastatic invasion. + termDef: + term: >- + Anti-CD205 Antibody-drug Conjugate OBT076 + source: NCIt + cde_id: C165598 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165598" + term_id: C165598 + term_version: 20.10d + +anticd228mmae_antibodydrug_conjugate_sgncd228a: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a humanized antibody targeting + the cell surface antigen cluster of differentiation (CD228; melanotransferrin; + MFI2; MELTF) that is conjugated, via a beta-glucuronidase-cleavable linker, + to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), + with potential antineoplastic activity. Following administration, the antibody + moiety of anti-CD228/MMAE ADC SGN-CD228A targets and binds to CD228 on the surface + of tumor cells. Following internalization of SGN-CD228A and release of MMAE, + MMAE targets and binds to tubulin, and inhibits microtubule polymerization. + This results in G2/M phase cell cycle arrest and apoptosis in CD228-expressing + tumor cells. CD228, a cell-surfaced, glycosylphosphatidylinoitol (GPI)-anchored + glycoprotein, belongs to the transferrin family of iron-binding proteins. + termDef: + term: >- + Anti-CD228/MMAE Antibody-drug Conjugate SGN-CD228A + source: NCIt + cde_id: C168772 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168772" + term_id: C168772 + term_version: 20.10d + +anticd25_monoclonal_antibody_ro7296682: + common: + description: >- + A monoclonal antibody against CD25 (IL-2R alpha), with potential antineoplastic + activity. Upon administration, the anti-CD25 monoclonal antibody RO7296682 targets + and binds to CD25 expressed on tumor-infiltrating regulatory T (Treg) cells. + This may deplete Treg cells and prevent immunosuppression, thereby enhancing + anti-tumor immune responses. CD25, the alpha chain of the interleukin (IL)-2 + receptor, is highly expressed on Treg cells but not on effector T (Teff) cells + in tumors. + termDef: + term: >- + Anti-CD25 Monoclonal Antibody RO7296682 + source: NCIt + cde_id: C173969 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173969" + term_id: C173969 + term_version: 20.10d + +anticd27_agonistic_monoclonal_antibody_mk5890: + common: + description: >- + A humanized agonistic monoclonal antibody targeting the cell surface antigen + CD27, with potential immunostimulatory and antineoplastic activities. Upon administration, + anti-CD27 agonistic monoclonal antibody MK-5890 targets and binds to CD27 on + a variety of immune cell types, including most T-lymphocytes. This induces CD27-dependent + signaling pathways and enhances T-cell-mediated responses, including the expansion + of antigen-activated T-cells and the cytotoxic T-lymphocyte (CTL)-mediated immune + response against tumor cells. CD27, a co-stimulatory molecule and member of + the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes, + memory B-cells and natural killer (NK) cells. It plays an important role in + NK cell-mediated cytolytic activity and T- and B-lymphocyte proliferation and + activation. It is overexpressed in certain tumor cell types. + termDef: + term: >- + Anti-CD27 Agonistic Monoclonal Antibody MK-5890 + source: NCIt + cde_id: C172056 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172056" + term_id: C172056 + term_version: 20.10d + +anticd30dm1_antibodydrug_conjugate_f0002: + common: + description: >- + An antibody drug conjugate (ADC) consisting of a monoclonal antibody directed + against the tumor necrosis factor (TNF) receptor CD30 conjugated, via a nonreducible + thioether linker (succinimidyl trans-4-(maleimidylmethyl)cyclohexane-1-carboxylate + or SMCC), to the cytotoxic agent maytansinoid mertansine (DM1), with potential + antineoplastic activity. Upon administration, the monoclonal antibody moiety + of F0002 targets and binds to CD30-expressing tumor cells. Upon cellular uptake + and internalization, the mertansine moiety binds to tubulin and interferes with + microtubule assembly and disassembly dynamics. This inhibits both cell division + and the proliferation of tumor cells that express CD30. Transiently activated + during lymphocyte activation, CD30 (tumor necrosis factor receptor superfamily, + member 8; TNFRSF8) may be constitutively expressed in some hematologic malignancies. + termDef: + term: >- + Anti-CD30/DM1 Antibody-drug Conjugate F0002 + source: NCIt + cde_id: C172064 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172064" + term_id: C172064 + term_version: 20.10d + +anticd37_bispecific_monoclonal_antibody_gen3009: + common: + description: >- + An Fc-engineered, humanized, bispecific hexamer formation-enhanced immunoglobulin + (Ig) G1 monoclonal antibody that targets two separate epitopes on the tumor-associated + antigen (TAA) CD37, with the E430G hexamerization-enhancing mutation, with potential + immunomodulating and antineoplastic activities. Upon administration, the anti-CD37 + bispecific monoclonal antibody GEN3009 specifically targets and binds to two + non-overlapping CD37 epitopes, thereby inducing an assembly of antibody hexamers + through intermolecular Fc-Fc interactions at the cell surface of CD37-overexpressing + tumor cells. These hexamers recruit and activate C1, the first component of + complement, thereby triggering the complement cascade which activates the immune + system to induce complement-dependent cytotoxicity (CDC). In addition, GEN3009 + binding to the CD37-overexpressing tumor cells also causes antibody-dependent + cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis + (ADCP). CD37, a member of the tetraspanin superfamily of cell surface antigens, + is expressed at high-levels on B cells and to a lesser extent on T cells and + myeloid cells. The E430G mutation in the Fc domains enhances Fc-mediated IgG + hexamerization upon cellular target binding, and enhances CDC. + termDef: + term: >- + Anti-CD37 Bispecific Monoclonal Antibody GEN3009 + source: NCIt + cde_id: C172443 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172443" + term_id: C172443 + term_version: 20.10d + +anticd38_antibodydrug_conjugate_sti6129: + common: + description: >- + An antibody-drug conjugate (ADC) composed of STI-5171, a fully human monoclonal + antibody targeting human cell surface glycoprotein and tumor-associated antigen + (TAA) CD38, site-specifically conjugated, via a non-polyethylene glycol linker, + to a monomethyl auristatin F (MMAF)-derived cytotoxic payload, with potential + antineoplastic activity. Upon administration of anti-CD38 ADC STI-6129, the + antibody moiety targets and binds to CD38 on tumor cells. Upon antibody/antigen + binding and internalization, the MMAF derivative binds to and inhibits tubulin + polymerization, which results in G2/M phase arrest and tumor cell apoptosis. + CD38, a type II transmembrane glycoprotein, is present on various immune cells + and hematologic malignancies; its expression has been correlated with poor prognosis. + termDef: + term: >- + Anti-CD38 Antibody-drug Conjugate STI-6129 + source: NCIt + cde_id: C174057 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174057" + term_id: C174057 + term_version: 20.10d + +anticd38_monoclonal_antibody_sar442085: + common: + description: >- + A preparation of Fc-engineered monoclonal antibody that targets the cell surface + glycoprotein CD-38 with potential antineoplastic activity. Although the exact + mechanisms(s) through which this agent exerts its effects have yet to be fully + elucidated, upon administration, anti-CD38 monoclonal antibody SAR442085 targets + and binds to CD38 on CD38-positive tumor cells. This may trigger, in addition + to other possible responses, antitumoral antibody-dependent cellular cytotoxicity + (ADCC) and may eventually lead to cell lysis in CD38-expressing tumor cells. + CD38, a type II transmembrane glycoprotein, is present on various immune cells + and hematologic malignancies. + termDef: + term: >- + Anti-CD38 Monoclonal Antibody SAR442085 + source: NCIt + cde_id: C166376 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166376" + term_id: C166376 + term_version: 20.10d + +anticd38cd28xcd3_trispecific_monoclonal_antibody_sar442257: + common: + description: >- + A tri-specific T-cell engager and monoclonal antibody targeting CD38, a human + cell surface glycoprotein and tumor-associated antigen (TAA), CD3, a T-cell + surface antigen, and CD28, a T-cell specific surface glycoprotein and co-stimulatory + molecule, with potential antineoplastic activity. Upon intravenous administration, + anti-CD38/CD3/CD28 tri-specific monoclonal antibody SAR442257 targets and binds + to CD3 and CD28 on T-cells and CD38 expressed on tumor cells. The resulting + cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against + CD38-expressing tumor cells. In addition, SAR442257 can also directly target + CD28 expressed on tumor cells, such as multiple myeloma cells, thereby enhancing + the anti-tumor activity of this agent and allowing it to bind to tumor cells + when CD38 is occupied by other antibodies. CD38, a type II transmembrane glycoprotein, + is present on various immune cells and hematologic malignancies; its expression + has been correlated with poor prognosis. + termDef: + term: >- + Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257 + source: NCIt + cde_id: C173645 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173645" + term_id: C173645 + term_version: 20.10d + +anticd39_monoclonal_antibody_srf617: + common: + description: >- + A fully human monoclonal antibody directed against the cell surface receptor + CD39 (cluster of differentiation 39; ectonucleoside triphosphate diphosphohydrolase-1; + NTPDase1; ENTPD1), with potential immunomodulating and antineoplastic activities. + Upon administration, anti-CD39 monoclonal antibody SRF617 specifically binds + to the CD39 antigen, thereby preventing the conversion and degradation of adenosine + triphosphate (ATP) to adenosine monophosphate (AMP). This leads to an increase + in the extracellular levels of immunogenic ATP and a decrease in the levels + of immunosuppressive adenosine within the tumor microenvironment (TME). A high + level of ATP increases pro-inflammatory cytokine levels and promotes both T-cell + proliferation and the stimulation of dendritic and other myeloid-derived cells + that are necessary for innate and adaptive immunity. CD39, a cell surface ectonucleosidase, + is upregulated on tumor cells as an immune evasion strategy. Blocking its action + may improve anti-tumor immune responses. + termDef: + term: >- + Anti-CD39 Monoclonal Antibody SRF617 + source: NCIt + cde_id: C171450 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171450" + term_id: C171450 + term_version: 20.10d + +anticd3anti5t4_bispecific_antibody_gen1044: + common: + description: >- + A recombinant immunoglobulin G1 (IgG1) bispecific antibody targeting both the + human T-cell surface antigen CD3 and oncofetal antigen 5T4, with potential immunomodulating + and antineoplastic activities. Upon administration, anti-CD3/anti-5T4 bispecific + antibody GEN1044 simultaneously targets and binds to CD3 expressed on T-cells + and 5T4 expressed on tumor cells. The resulting cross-linkage may trigger a + potent cytotoxic T-lymphocyte (CTL) response against the 5T4-expressing tumor + cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer + cell types; its expression is correlated with increased invasiveness. + termDef: + term: >- + Anti-CD3/Anti-5T4 Bispecific Antibody GEN1044 + source: NCIt + cde_id: C173369 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173369" + term_id: C173369 + term_version: 20.10d + +anticd3antigucy2c_bispecific_antibody_pf07062119: + common: + description: >- + A bispecific antibody against human CD3, a T-cell surface antigen, and human + guanylate cyclase 2C (GUCY2C; GCC; guanylyl cyclase C; heat-stable enterotoxin + receptor; hSTAR), with potential antineoplastic activity. Upon administration, + anti-CD3/anti-GUCY2C bispecific antibody PF-07062119 targets and binds to both + CD3 on T-cells and GUCY2C expressed on certain tumor cells. This results in + the cross-linking of T-cells and tumor cells, and induces a cytotoxic T-lymphocyte + (CTL) response against GUCY2C-expressing tumor cells. GUCY2C, a transmembrane + receptor expressed on intestinal epithelial cells, is overexpressed on certain + tumors of the gastrointestinal (GI) tract. + termDef: + term: >- + Anti-CD3/Anti-GUCY2C Bispecific Antibody PF-07062119 + source: NCIt + cde_id: C166258 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166258" + term_id: C166258 + term_version: 20.10d + +anticd3cd7ricin_toxin_a_immunotoxin: + common: + description: >- + An immunotoxin (IT) combination composed of two antibody-drug conjugates (ADCs), + one containing a monoclonal antibody against CD3 and one against the CD7 antigen + on activated T-cells and natural killer (NK) cells, and both conjugated to ricin + toxin A (RTA), the A-chain form of the potent plant toxin ricin, that can potentially + be used to destroy activated T- and NK cells. Upon administration of the anti-CD3/CD7-RTA + immunotoxin, the anti-CD3 antibody moiety targets and binds to activated T-cells; + the anti-CD7 antibody moiety targets and binds to CD7 on activated T-cells and + NK cells. Upon internalization and cleavage, the RTA moiety irreversibly inhibits + protein synthesis and induces apoptosis in the activated T-cells. This may eliminate + activated T-cells and may improve conditions such as graft-versus-host-disease + (GvHD). In addition, the binding and blocking of the anti-CD3 antibody to the + T-cell receptor/CD3 complex (TCR/CD3) results in activation-induced cell death + (AICD) and immunosuppression. + termDef: + term: >- + Anti-CD3/CD7-Ricin Toxin A Immunotoxin + source: NCIt + cde_id: C165583 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165583" + term_id: C165583 + term_version: 20.10d + +anticd40anti41bb_bispecific_agonist_monoclonal_antibody_gen1042: + common: + description: >- + A humanized immunoglobulin (Ig) G1, Fc-silenced, bispecific, agonistic monoclonal + antibody targeting both CD40 and 4-1BB (CD137; tumor necrosis factor receptor + superfamily member 9; TNFRSF9), with potential immunostimulatory and antineoplastic + activity. Upon administration, anti-CD40/anti-4-1BB bispecific agonist monoclonal + antibody GEN1042 simultaneously binds to CD40 and 4-1BB, crosslinks CD40 and + 4-1BB positive cells, induces conditional stimulation, and activates both CD40- + and 4-1BB-medicated signaling. The activation of CD40-mediated signaling triggers + the proliferation and activation of antigen-presenting cells (APCs) and activates + T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune + response against tumor cells. The activation of 4-1BB-mediated signaling induces + cytokine production and promotes T-cell mediated anti-tumor immune responses. + CD40, a cell surface receptor and member of the tumor necrosis factor receptor + superfamily (TNFRSF), is expressed on various immune cells, such as dendritic + cells (DCs), macrophages and B-cells, and plays a key role in the activation + of the immune system. 4-1BB, a surface glycoprotein of the TNFRSF, is an inducible + costimulatory receptor that plays a key role in T-cell proliferation, survival + and cytolytic activity. + termDef: + term: >- + Anti-CD40/Anti-4-1BB Bispecific Agonist Monoclonal Antibody GEN1042 + source: NCIt + cde_id: C168604 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168604" + term_id: C168604 + term_version: 20.10d + +anticd47_adc_sgncd47m: + common: + description: >- + An antibody-drug conjugate (ADC) consisting of a monoclonal antibody directed + against human cell surface antigen CD47 conjugated to an as of yet not fully + elucidated toxin, with potential antineoplastic activity. Upon administration + of SGN-CD47M, the anti-CD47 monoclonal antibody moiety targets and binds to + CD47 on tumor cell surfaces; upon internalization, the toxin moiety kills tumor + cells through a mechanism of action that has not been elucidated. CD47, also + called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) + expressed on normal, healthy hematopoietic stem cells (HSCs) and overexpressed + on the surface of a variety of cancer cells. + termDef: + term: >- + Anti-CD47 ADC SGN-CD47M + source: NCIt + cde_id: C173421 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173421" + term_id: C173421 + term_version: 20.10d + +anticd47_monoclonal_antibody_imc002: + common: + description: >- + A human immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface + antigen CD47, with potential immune checkpoint inhibitory and antineoplastic + activities. Upon administration, anti-CD47 monoclonal antibody IMC-002 targets + and binds to CD47 expressed on tumor cells, blocking the interaction of CD47 + with signal regulatory protein alpha (SIRPa) expressed on phagocytic cells. + This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated + inhibition of macrophage activation and phagocytosis of cancer cells. This induces + pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which + is specifically expressed on the surface of tumor cells, to low-density lipoprotein + (LDL) receptor-related protein-1 (LRP-1), which is expressed on macrophages, + and results in macrophage activation and the specific phagocytosis of tumor + cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated + antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) and + overexpressed on the surface of a variety of cancer cells. Expression of CD47, + and its interaction with SIRPa, leads to the inhibition of macrophage activation + and protects cancer cells from phagocytosis, thereby allowing cancer cells to + proliferate. IMC-002 does not bind to red blood cells (RBCs). This may prevent + adverse effects such as anemia that can result from the blockade of CD47 expressed + on RBCs. + termDef: + term: >- + Anti-CD47 Monoclonal Antibody IMC-002 + source: NCIt + cde_id: C174192 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174192" + term_id: C174192 + term_version: 20.10d + +anticd47cd19_bispecific_monoclonal_antibody_tg1801: + common: + description: >- + A bispecific monoclonal antibody composed of two single-chain variable fragments + (scFv), one directed against the B-cell-specific membrane protein CD19, and + another that is directed against the human cell surface antigen CD47, with potential + immunostimulating, phagocytosis-inducing and antineoplastic activities. Upon + administration of anti-CD47/CD19 bispecific monoclonal antibody TG-1801, the + anti-CD19 moiety selectively targets and binds to CD19 on CD19-positive B-cells, + thereby improving binding of the anti-CD47 moiety to the CD19+ malignant B-cells. + The CD47 binding by TG-1801 blocks the interaction of CD47 with signal regulatory + protein alpha (SIRPalpha), an inhibitory protein expressed on macrophages and + dendritic cells (DCs), which prevents CD47/SIRPalpha-mediated signaling and + abrogates the CD47/SIRPalpha-mediated inhibition of phagocytosis. This induces + pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which + is specifically expressed on the surface of tumor cells, to low-density lipoprotein + (LDL) receptor-related protein (LRP), expressed on macrophages, which results + in macrophage activation and the specific phagocytosis of the CD19/CD47-expressing + tumor cells. Additionally, blocking CD47 signaling activates an anti-tumor T-lymphocyte + immune response and T-cell-mediated killing of CD19/CD47-expressing tumor cells. + In addition, TG-1801 induces an anti-tumor activity through the induction of + antibody dependent cellular cytotoxicity (ADCC). CD47, also called integrin-associated + protein (IAP), is a tumor-associated antigen (TAA), widely expressed on normal, + healthy cells, such as red blood cells and platelets, and overexpressed on the + surface of a variety of cancer cells. Expression of CD47, and its interaction + with SIRPalpha, leads to the inhibition of macrophage activation and protects + cancer cells from phagocytosis, which allows cancer cells to proliferate. CD19 + is a membrane antigen that is widely expressed during B-cell development and + in B-cell malignancies. By co-targeting CD47 and CD19, TG-1801 has the potential + to overcome the limitations of existing CD47-targeted therapies by possibly + avoiding the side effects caused by binding to CD47 on healthy hematopoietic + stem cells (HSCs) which causes unwanted macrophage-mediated phagocytosis. + termDef: + term: >- + Anti-CD47/CD19 Bispecific Monoclonal Antibody TG-1801 + source: NCIt + cde_id: C166137 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166137" + term_id: C166137 + term_version: 20.10d + +anticlaudin182_monoclonal_antibody_ab011: + common: + description: >- + A recombinant humanized monoclonal antibody directed against the tumor-associated + antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential + immunostimulating and antineoplastic activities. Upon administration, anti-claudin18.2 + monoclonal antibody AB011 specifically targets, binds to and inhibits CLDN18.2 + expressed on tumor cells. This may kill CLDN18.2-expressing tumor cells and + inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific + isoform of claudin-18, is expressed on a variety of tumor cells, but its expression + in healthy tissues is strictly confined to short-lived differentiated epithelial + cells of the gastric mucosa. + termDef: + term: >- + Anti-claudin18.2 Monoclonal Antibody AB011 + source: NCIt + cde_id: C173724 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173724" + term_id: C173724 + term_version: 20.10d + +anticlaudin182_monoclonal_antibody_tst001: + common: + description: >- + A recombinant humanized immunoglobulin G1 (IgG1) monoclonal antibody directed + against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform + of claudin-18), with potential immunostimulating and antineoplastic activities. + Upon administration, anti-claudin18.2 monoclonal antibody TST001 specifically + targets, binds to and inhibits CLDN18.2 expressed on tumor cells. This may kill + CLDN18.2-expressing tumor cells by antibody-dependent cellular cytotoxicity + (ADCC) and complement-dependent cytotoxicity (CDC), and inhibit cell proliferation. CLDN18.2, + a tight junction protein and stomach-specific isoform of claudin-18, is overexpressed + on a variety of tumor cells, but its expression in healthy tissues is strictly + confined to short-lived differentiated epithelial cells of the gastric mucosa. + TST001 is produced with reduced fucosylation. + termDef: + term: >- + Anti-Claudin18.2 Monoclonal Antibody TST001 + source: NCIt + cde_id: C173726 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173726" + term_id: C173726 + term_version: 20.10d + +anticmet_monoclonal_antibody_hlx55: + common: + description: >- + A humanized immunoglobulin (Ig) G2 monoclonal antibody directed against the + human hepatocyte growth factor receptor (HGFR or c-Met), with potential antineoplastic + activity. Upon administration, anti-c-Met monoclonal antibody HLX55 specifically + binds to the semaphorin (Sema)/Plexins-Semaphorins-Integrins (PSI) domain of + c-Met, which prevents the binding of c-Met to its ligand HGF and the subsequent + activation of the HGF/c-Met signaling pathway. In addition, HLX55 promotes c-Met + degradation, which further inhibits c-Met-mediated signaling. This may result + in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase + overexpressed or mutated in many tumor cell types, plays a key role in cancer + cell growth, survival, angiogenesis, invasion, and metastasis. + termDef: + term: >- + Anti-c-Met Monoclonal Antibody HLX55 + source: NCIt + cde_id: C174391 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174391" + term_id: C174391 + term_version: 20.10d + +antictla4_antibody_fc_fusion_protein_kn044: + common: + description: >- + A recombinant, humanized fusion protein consisting of a cytotoxic T-lymphocyte-associated + antigen 4 (CTLA4; CTLA-4) single domain antibody linked to a Fc domain, with + potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, + anti-CTLA4 antibody Fc fusion protein KN044 targets and binds to CTLA4 expressed + on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. + This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against + cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin + superfamily (IgSF), plays a key role in the downregulation of the immune system. + termDef: + term: >- + Anti-CTLA4 Antibody Fc Fusion Protein KN044 + source: NCIt + cde_id: C173422 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173422" + term_id: C173422 + term_version: 20.10d + +antictla4_monoclonal_antibody_adg116: + common: + description: >- + A human monoclonal antibody directed against the human T-cell-expressed receptor + cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential + immune checkpoint inhibitory and antineoplastic activities. Upon intravenous + administration, anti-CTLA-4 monoclonal antibody ADG116 targets and binds to + CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation + of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated + immune response against cancer cells, thereby killing cancer cells. CTLA-4, + an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), + plays a key role in the downregulation of the immune system. + termDef: + term: >- + Anti-CTLA-4 Monoclonal Antibody ADG116 + source: NCIt + cde_id: C166139 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166139" + term_id: C166139 + term_version: 20.10d + +antictla4_monoclonal_antibody_hbm4003: + common: + description: >- + A recombinant human heavy chain only antibody (HCAb) directed against the human + T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4;CTLA4), + with potential immune checkpoint inhibitory and antineoplastic activities. Upon + administration, anti-CTLA-4 monoclonal antibody HBM4003 targets and binds to + CTLA-4 expressed on T-cells, and inhibits the CTLA-4-mediated downregulation + of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated + immune response against cancer cells. In addition, HBM4003 induces an antibody-dependent + cell cytotoxicity (ADCC). CTLA-4, an inhibitory receptor and member of the immunoglobulin + superfamily (IgSF), plays a key role in the downregulation of the immune system. + HBM4003, being a HCAb, is smaller than conventional antibodies which may allow + for increased tissue penetration. + termDef: + term: >- + Anti-CTLA-4 Monoclonal Antibody HBM4003 + source: NCIt + cde_id: C173540 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173540" + term_id: C173540 + term_version: 20.10d + +antictla4_monoclonal_antibody_onc392: + common: + description: >- + A humanized, pH-sensitive immunoglobulin (Ig) G1 monoclonal antibody directed + against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated + antigen 4 (CTLA4; CTLA-4; CD152), with potential immune checkpoint inhibitory + and antineoplastic activities. Upon administration, anti-CTLA-4 monoclonal antibody + ONC-392 targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated + downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte + (CTL)-mediated immune response against cancer cells, thereby killing cancer + cells. As ONC-392 is dissociated from CTLA-4 under low pH, it does not cause + lysosomal degradation of CTLA-4, preserving CTLA-4 and allowing the recycling + of CTLA-4. This may result in more efficient and selective CTLA-4-targeted regulatory + T-cell (Treg) depletion within the tumor microenvironment (TME) while preserving + CTLA-4 functions outside the TME, thereby reducing toxicities. CTLA-4, an inhibitory + receptor and member of the immunoglobulin superfamily (IgSF), plays a key role + in the downregulation of the immune system. + termDef: + term: >- + Anti-CTLA-4 Monoclonal Antibody ONC-392 + source: NCIt + cde_id: C173547 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173547" + term_id: C173547 + term_version: 20.10d + +antictla4_probody_bms986288: + common: + description: >- + A probody composed of a modified version of ipilimumab, a recombinant human + monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated + antigen 4 (CTLA4; CTLA-4), linked to a proprietary masking peptide that covers + the active antigen-binding site of the antibody through a protease-cleavable + linker, with potential immune checkpoint inhibitory and antineoplastic activities. + Upon administration of anti-CTLA-4 probody BMS-986288, the masking peptide is + cleaved by tumor-associated proteases upon extravasation into the tumor microenvironment + (TME). Protease-mediated removal of the linker enables binding of the unmasked + monoclonal antibody moiety to CTLA-4, which is expressed on certain T-cells. + This inhibits the CTLA4-mediated downregulation of T-cell activation, and leads + to both activation of tumor infiltrating T-effector cells and a cytotoxic T-lymphocyte + (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor + and member of the immunoglobulin superfamily expressed on activated effector + T-cells (Teffs) and regulatory T-cells (Tregs), plays a key role in the inhibition + of T-cell activity and downregulation of the immune system. The peptide masking + of BMS-986288 minimizes binding to CTLA-4 in normal tissues and may reduce systemic + toxicity, when compared to ipilimumab. Tumor-associated proteases are present + in high concentrations and aberrantly activated in the TME. + termDef: + term: >- + Anti-CTLA-4 Probody BMS-986288 + source: NCIt + cde_id: C173435 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173435" + term_id: C173435 + term_version: 20.10d + +antictla4antipd1_monoclonal_antibody_combination_bcd217: + common: + description: >- + A fixed dose combination of two monoclonal antibodies of which one is directed + against the human negative immunoregulatory checkpoint receptor programmed cell + death protein 1 (PD-1; PDCD1; CD279) and the other one is directed against the + cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + anti-CTLA-4/anti-PD-1 monoclonal antibody combination BCD-217 targets and binds + to both PD-1 and CTLA-4 expressed on tumor-infiltrating lymphocytes (TILs) and + inhibits the PD-1- and CTLA-4-mediated downregulation of T-cell activation and + proliferation. This restores immune function and activates a cytotoxic T-lymphocyte + (CTL)-mediated immune response against tumor cells. Both PD-1 and CTLA-4 are + selectively expressed on TILs in the tumor microenvironment (TME) and negatively + regulate the activation and effector functions of T-cells. They play key roles + in the downregulation of the immune system and tumor evasion from host immunity. + Dual checkpoint blockade of PD-1 and CTLA-4 enhances T-cell activation and proliferation + more than the blockade of either immune checkpoint receptor alone. + termDef: + term: >- + Anti-CTLA-4/Anti-PD-1 Monoclonal Antibody Combination BCD-217 + source: NCIt + cde_id: C172196 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172196" + term_id: C172196 + term_version: 20.10d + +antiegfrcd16a_bispecific_antibody_afm24: + common: + description: >- + A human, tetravalent, bispecific antibody targeting both the epidermal growth + factor receptor (EGFR) and the human low affinity IgG Fc region receptor IIIA + (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities. + Upon administration, anti-EGFR/CD16A bispecific antibody AFM24 simultaneously + targets and binds to the CD16A expressed on natural killer (NK) cells and macrophages, + and to EGFR on EGFR-expressing tumor cells, thereby selectively cross-linking + EGFR-expressing tumor cells with NK cells and macrophages. This may result in + NK cell and macrophage activation, antibody-dependent cellular cytotoxicity + (ADCC), antibody-dependent cellular phagocytosis (ADCP), and eventually tumor + cell lysis. EGFR, a receptor tyrosine kinase upregulated or mutated in many + tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. + CD16A is specifically expressed on the surface of NK cells and macrophages. + termDef: + term: >- + Anti-EGFR/CD16A Bispecific Antibody AFM24 + source: NCIt + cde_id: C171163 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171163" + term_id: C171163 + term_version: 20.10d + +antifraeribulin_antibodydrug_conjugate_morab202: + common: + description: >- + An antibody drug conjugate (ADC) composed of farletuzumab, a humanized immunoglobulin + G1 (IgG1) monoclonal antibody directed against the folate receptor alpha (FRA; + FolRa; FOLR1), and conjugated, via a cathepsin B-cleavable linker, to the microtubule-targeting + agent (MTA) eribulin, a derivative of the macrocyclic polyether natural product + halichondrin B, with potential antineoplastic activity. Upon administration + of MORAb-202, the farletuzumab moiety targets and binds to FRA expressed on + certain tumor cells. Upon binding, internalization, and enzymatic cleavage, + eribulin binds to the vinca domain of tubulin and inhibits the polymerization + of tubulin and the assembly of microtubules, resulting in inhibition of mitotic + spindle assembly, induction of cell cycle arrest at G2/M phase, and the induction + of tumor cell death in FRA-expressing cells. FRA is a glycosylphosphatidylinositol + linked cell-surface glycoprotein that is widely expressed in certain cancers + while its expression is limited in normal tissues. + termDef: + term: >- + Anti-FRA/Eribulin Antibody-drug Conjugate MORAb-202 + source: NCIt + cde_id: C173946 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173946" + term_id: C173946 + term_version: 20.10d + +antigarp_monoclonal_antibody_abbv151: + common: + description: >- + A humanized monoclonal antibody directed against the transforming growth factor + beta (TGFbeta) activator, glycoprotein A repetitions predominant (GARP; leucine-rich + repeat-containing protein 32; LRRC32), with potential immunomodulating and antineoplastic + activities. Upon administration, anti-GARP monoclonal antibody ABBV-151 selectively + targets and binds to GARP which interferes with the production and release of + active TGFbeta by regulatory T-cells (Tregs). Selective inhibition of the release + of TGFbeta from Tregs leads to a reversal of immunosuppression thereby increasing + the immune response to tumor cells. GARP, a leucine-rich repeat-containing protein, + is essential for the expression of TGFbeta on the cell surface of activated + Tregs; it plays an important role in regulation of the immune cell function. + termDef: + term: >- + Anti-GARP Monoclonal Antibody ABBV-151 + source: NCIt + cde_id: C165684 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165684" + term_id: C165684 + term_version: 20.10d + +antiglobo_hmmae_antibodydrug_conjugate_obi_999: + common: + description: >- + An antibody-drug conjugate (ADC) composed of OBI-888 (OBI 888), a humanized + monoclonal antibody directed against the tumor-associated antigen (TAA) globohexaosylceramide + (globo H), covalently linked to monomethyl auristatin E (MMAE), an auristatin + derivative and a potent microtubule disrupting agent, with potential antineoplastic + activity. Upon administration of anti-globo H/MMAE ADC OBI 999, the antibody + moiety of OBI 999, OBI 888, targets and binds to globo H on tumor cells and + is rapidly internalized, thereby delivering MMAE intracellularly. Upon proteolytic + cleavage, MMAE targets and binds to tubulin and inhibits its polymerization, + resulting in G2/M checkpoint arrest and apoptosis in globo H-expressing tumor + cells. Globo H, a hexasaccharide glycosphingolipid, is (over)expressed on the + surface of many types of tumor cells. Globo H is minimally or not expressed + on healthy, normal cells; its expression on cancer cells is associated with + increased proliferation and poor prognosis. + termDef: + term: >- + Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999 + source: NCIt + cde_id: C165657 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165657" + term_id: C165657 + term_version: 20.10d + +antigpr20dxd_antibodydrug_conjugate_ds6157a: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed + against the G protein-coupled receptor 20 (GPR20) conjugated to the cytotoxic + DNA topoisomerase I inhibitor and exatecan derivative DXd (MAAA-1181a; MAAA-1181), + with potential antineoplastic activity. Upon administration of the anti-GPR20/DXd + ADC DS-6157a, the anti-GPR20 antibody targets and binds to GPR20-expressing + tumor cells. Upon cellular uptake, the DXd moiety targets and binds to DNA topoisomerase + I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, + resulting in DNA breaks, inhibition of DNA replication and apoptosis. This inhibits + the proliferation of GPR20-expressing tumor cells. GPR20 is overexpressed on + certain tumor cell types. + termDef: + term: >- + Anti-GPR20/DXd Antibody-drug Conjugate DS-6157a + source: NCIt + cde_id: C172987 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172987" + term_id: C172987 + term_version: 20.10d + +antigremlin1_monoclonal_antibody_ucb6114: + common: + description: >- + A monoclonal antibody directed against gremlin-1 (GREM1; Drm), with potential + antineoplastic activity. Upon administration, anti-gremlin-1 antibody UCB6114 + specifically targets and binds to gremlin-1, thereby neutralizing Gremlin-1. + This may block the gremlin-1-mediated inhibition of bone morphogenetic protein + (BMP) signaling pathways, and may lead to the inhibition of tumor cell growth + and proliferation. Gremlin-1, a BMP antagonist that is overexpressed in a variety + of cancer cell types, is involved in cancer cell growth and proliferation as + well as tissue fibrosis. + termDef: + term: >- + Anti-gremlin-1 Monoclonal Antibody UCB6114 + source: NCIt + cde_id: C173701 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173701" + term_id: C173701 + term_version: 20.10d + +antigua_and_barbuda: + common: + description: >- + A group of islands in the Caribbean Sea, east of Saint Kitts and Nevis. + termDef: + term: >- + Antigua and Barbuda + source: NCIt + cde_id: C16303 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16303" + term_id: C16303 + term_version: 19.12e + +antiher2_antibody_conjugated_natural_killer_cells_ace1702: + common: + description: >- + An off-the-shelf preparation of natural killer (NK) cells conjugated to a monoclonal + antibody targeting human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), + with potential antineoplastic activity. Upon administration of anti-HER2 antibody + conjugated natural killer cells ACE1702, the antibody moiety targets and binds + to HER2 on tumor cells, which may lead to cell lysis of HER2-expressing tumor + cells by the NK cells. HER2, a tyrosine kinase receptor, is overexpressed by + many cancer cell types. + termDef: + term: >- + Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702 + source: NCIt + cde_id: C173076 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173076" + term_id: C173076 + term_version: 20.10d + +antiher2_antibodydrug_conjugate_bat8001: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed + against the tumor-associated antigen (TAA) human epidermal growth factor receptor + 2 (EGFR2; HER2; ErbB2) conjugated via an uncleavable linker to an as of yet + undisclosed maytansine derivative, with potential antineoplastic activity. Upon + administration of the anti-HER2 ADC BAT8001, the anti-HER2 monoclonal antibody + targets and binds to HER2 expressed on tumor cells. Upon cellular uptake, the + cytotoxic maytansine derivative binds to tubulin, thereby affecting microtubule + assembly and disassembly dynamics. This inhibits tumor cell proliferation and + induces apoptosis in HER2-expressing tumor cells. HER2, a tyrosine kinase receptor, + is overexpressed by many cancer cell types. + termDef: + term: >- + Anti-HER2 Antibody-drug Conjugate BAT8001 + source: NCIt + cde_id: C173966 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173966" + term_id: C173966 + term_version: 20.10d + +antiher2_antibodydrug_conjugate_dp303c: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting + human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) and conjugated + to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. + Upon administration of anti-HER2 ADC DP303c, the antibody moiety targets and + binds to HER2 on tumor cells. Upon antibody/antigen binding and internalization, + the cytotoxic agent induces tumor cell apoptosis, through an as of yet not publicly + known mechanism. HER2, a tyrosine kinase receptor, is overexpressed by many + cancer cell types. + termDef: + term: >- + Anti-HER2 Antibody-drug Conjugate DP303c + source: NCIt + cde_id: C173962 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173962" + term_id: C173962 + term_version: 20.10d + +antiher2_monoclonal_antibody_b002: + common: + description: >- + A humanized monoclonal antibody directed against the human epidermal growth + factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic activity. + Upon administration, anti-HER2 monoclonal antibody B002 targets and binds to + HER2 on HER2-expressing tumor cells. This prevents HER2-mediated signaling and + may lead to antitumor activity. HER2, a tyrosine kinase receptor, is overexpressed + by many cancer cell types. + termDef: + term: >- + Anti-HER2 Monoclonal Antibody B002 + source: NCIt + cde_id: C174121 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174121" + term_id: C174121 + term_version: 20.10d + +antiher2_monoclonal_antibody_hlx22: + common: + description: >- + A humanized immunoglobulin (lg) G1 monoclonal antibody directed against the + human epidermal growth factor receptor 2 (HER2), with potential immunomodulating + and antineoplastic activity. Upon administration, anti-HER2 monoclonal antibody + HLX22 targets and binds to HER2 on tumor cell surface. This may induce a cytotoxic + T-lymphocyte (CTL) response as well as an antibody-dependent cell-mediated cytotoxicity + (ADCC) against tumor cells that overexpress HER2. HER2, a tyrosine kinase receptor, + is overexpressed by many cancer cell types. + termDef: + term: >- + Anti-HER2 Monoclonal Antibody HLX22 + source: NCIt + cde_id: C172198 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172198" + term_id: C172198 + term_version: 20.10d + +antiher2dm1_adc_b003: + common: + description: >- + An antibody-drug conjugate (ADC) consisting of a recombinant humanized anti-epidermal + growth factor receptor 2 (HER2) monoclonal antibody conjugated to the maytansinoid + DM1 via a nonreducible thioether linkage (MCC), with potential antineoplastic + activity. Upon administration of B003, the anti-HER2 monoclonal antibody moiety + targets and binds to HER2 on tumor cell surfaces; upon internalization, the + DM1 moiety is released and binds to tubulin, thereby disrupting microtubule + assembly/disassembly dynamics, inhibiting cell division and the proliferation + of cancer cells that overexpress HER2. + termDef: + term: >- + Anti-HER2-DM1 ADC B003 + source: NCIt + cde_id: C173420 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173420" + term_id: C173420 + term_version: 20.10d + +antiher2dm1_antibodydrug_conjugate_gq1001: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting + human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) and conjugated, + via a site-specific linker, to the cytotoxic maytansinoid mertansine (DM1), + with potential antineoplastic activity. Upon administration of anti-HER2-DM1 + ADC GQ1001, the antibody moiety targets and binds to HER2 on tumor cell surfaces. + Upon cellular uptake and internalization, DM1 binds to tubulin and interferes + with microtubule assembly and disassembly dynamics. This inhibits cell division + and the proliferation of tumor cells that overexpress HER2. HER2, a tyrosine + kinase receptor, is overexpressed by many cancer cell types. + termDef: + term: >- + Anti-HER2-DM1 Antibody-drug Conjugate GQ1001 + source: NCIt + cde_id: C173827 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173827" + term_id: C173827 + term_version: 20.10d + +antiher2mmae_antibodydrug_conjugate_mrg002: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) + monoclonal antibody directed against the tumor-associated antigen (TAA) human + epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) conjugated to the microtubule-disrupting + cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic + activity. Following administration, the antibody moiety of anti-HER2/MMAE ADC + MRG002 targets and binds to HER2 on the surface of tumor cells. Following internalization + of MRG002, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. + This results in G2/M phase cell cycle arrest and apoptosis in HER2-expressing + tumor cells. HER2, a tyrosine kinase receptor, is overexpressed by many cancer + cell types. + termDef: + term: >- + Anti-HER2/MMAE Antibody-drug Conjugate MRG002 + source: NCIt + cde_id: C174205 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174205" + term_id: C174205 + term_version: 20.10d + +antihlag_antibody_ttx080: + common: + description: >- + An antibody targeting HLA-G histocompatibility antigen, class I, G (human leukocyte + antigen G; HLA-G), with potential immune checkpoint inhibiting, immunomodulating + and antineoplastic activities. Upon administration, the anti-HLA-G antibody + TTX-080 targets and binds to HLA-G, thereby preventing the binding of HLA-G + to its inhibitory receptors on a variety of immune cells, such as natural killer + cells (NKs), T- and B-lymphocytes, and dendritic cells (DCs). This may prevent + the HLA-G-mediated immune suppression, thereby activating both innate and adaptive + immune responses. This may activate anti-tumor immune responses. HLA-G, an immune + checkpoint normally expressed at the maternal-fetal interface, is expressed + across multiple tumor types and plays a key role in cancer immune evasion. + termDef: + term: >- + Anti-HLA-G Antibody TTX-080 + source: NCIt + cde_id: C175374 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175374" + term_id: C175374 + term_version: 20.10d + +antiil8_monoclonal_antibody_bms986253: + common: + description: >- + A human monoclonal antibody against the pro-inflammatory mediator interleukin-8 + (IL-8; CXCL8), with potential antineoplastic activities. Upon administration, + BMS-986253 directly binds to IL-8, thereby inhibiting the binding of IL-8 to + its receptors CXCR1 and CXCR2. This inhibits activation of IL-8-mediated signaling + transduction pathways, which decreases proliferation of susceptible tumor cells. + Also, BMS-986253 effectively blocks binding of IL-8 to neutrophils and inhibits + neutrophil activation and recruitment towards sites of inflammation, which reduces + inflammation. IL-8, a member of the CXC chemokine family, is upregulated in + a variety of cancer cell types and inflammatory diseases; it plays a key role + in tumor cell proliferation, endothelial cell proliferation, and cancer stem + cell (CSC) renewal. + termDef: + term: >- + Anti-IL-8 Monoclonal Antibody BMS-986253 + source: NCIt + cde_id: C124227 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124227" + term_id: C124227 + term_version: 20.10d + +antiintegrin_beta6mmae_antibodydrug_conjugate_sgnb6a: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a humanized antibody targeting + integrin beta-6 and conjugated to the microtubule-disrupting cytotoxic agent + monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon + administration, the antibody moiety of anti-integrin beta-6/MMAE ADC SGN-B6A + targets and binds to integrin beta-6 on the surface of tumor cells. Following + internalization of SGN-B6A and release of MMAE, MMAE targets and binds to tubulin, + and inhibits microtubule polymerization. This results in G2/M phase cell cycle + arrest and apoptosis in integrin beta-6-expressing tumor cells. Integrin beta-6 + is a subunit of integrin alpha-V beta-6 (aVb6). Integrin aVb6, a cell adhesion + and signaling receptor, is upregulated in certain cancer cell types and has + been associated with increased proliferation, migration and invasion of tumor + cells. + termDef: + term: >- + Anti-integrin Beta-6/MMAE Antibody-drug Conjugate SGN-B6A + source: NCIt + cde_id: C172391 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172391" + term_id: C172391 + term_version: 20.10d + +antiirf4_antisense_oligonucleotide_ion251: + common: + description: >- + An antisense oligonucleotide (ASO) targeting the interferon regulatory factor + 4 (IRF4) mRNA, with potential immunomodulating and antineoplastic activities. + Upon intravenous administration, anti-IRF4 ASO ION251 hybridizes with IRF4 mRNA, + which blocks translation of the IRF4 protein. Reduction of IRF4 levels prevents + the expression of IRF4-controlled tumor promoter genes, and may enhance tumor + cell apoptosis and prevent T-cell exhaustion. IRF4, a transcription factor expressed + in lymphocytes and essential for plasma cell differentiation, is involved in + immune cell development and plays a key role in T-cell functions. It is overexpressed + in certain tumor cell types and is a key regulator of multiple genes controlling + tumor cell survival. + termDef: + term: >- + Anti-IRF4 Antisense Oligonucleotide ION251 + source: NCIt + cde_id: C173725 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173725" + term_id: C173725 + term_version: 20.10d + +antilag3_monoclonal_antibody_ibi110: + common: + description: >- + A monoclonal antibody targeting the co-inhibitory receptor lymphocyte-activation + gene 3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory + and antineoplastic activities. Upon administration, anti-LAG-3 monoclonal antibody + IBI110 targets and binds to LAG-3 expressed by tumor infiltrating lymphocytes + (TILs) and blocks the interaction between LAG-3 and major histocompatibility + complex class II (MHC II) molecules on the surface of antigen-presenting cells + (APCs) and tumor cells. This prevents the negative regulation of T-cell activity + that occurs via LAG-3-MHC II binding and enhances a cytotoxic T-lymphocyte (CTL)-mediated + immune response against tumor cells, leading to a reduction in tumor growth. + LAG-3, a member of the immunoglobulin superfamily (IgSF), negatively regulates + both the proliferation and activation of T-cells. Its expression on TILs is + associated with tumor-mediated immune suppression. + termDef: + term: >- + Anti-LAG-3 Monoclonal Antibody IBI-110 + source: NCIt + cde_id: C168603 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168603" + term_id: C168603 + term_version: 20.10d + +antilatent_tgfbeta_1_monoclonal_antibody_srk181: + common: + description: >- + A monoclonal antibody directed against latent human transforming growth factor + (TGF)-beta 1 (TGFb1; TGF-b1), with potential antineoplastic activity. Upon administration, + anti-latent TGFb1 monoclonal antibody SRK-181 specifically targets, binds to, + and inhibits the activation of latent TGFb1 complexes, thereby preventing TGFb1-mediated + signaling. This abrogates TGFb1-mediated immunosuppression, enhances anti-tumor + immunity in the tumor microenvironment (TME) and promotes a cytotoxic T-lymphocyte + (CTL)-mediated immune response against tumor cells leading to tumor cell death. + This may lead to a reduction in TGFb1-dependent proliferation of cancer cells. + The TGF-beta signaling pathway is often deregulated in tumors and plays a key + role in the regulation of cell growth, differentiation, apoptosis, motility, + invasion, and angiogenesis. It plays a key role in immunosuppression in the + TME. TGFb1 is the predominant isoform in many tumors. + termDef: + term: >- + Anti-latent TGF-beta 1 Monoclonal Antibody SRK-181 + source: NCIt + cde_id: C173598 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173598" + term_id: C173598 + term_version: 20.10d + +antilewis_blewis_y_monoclonal_antibody_gnx102: + common: + description: >- + A humanized monoclonal antibody directed against human tumor-associated carbohydrate + antigens (TACAs) Lewis B (LeB) and Lewis Y (LeY), with potential antineoplastic + activity. Upon administration, anti-LeB/LeY monoclonal antibody GNX102 binds + to branched LeB and LeY glycans, which may induce an antibody-dependent cellular + cytotoxicity (ADCC) response against LeB- and LeY-expressing tumor cells. LeB + and LeY antigens, tetrasaccharides with low to moderate expression in monomeric + form in normal adult tissues, is overexpressed in branched form in multiple + forms of cancers. + termDef: + term: >- + Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102 + source: NCIt + cde_id: C175411 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175411" + term_id: C175411 + term_version: 20.10d + +antililrb4_monoclonal_antibody_io202: + common: + description: >- + A monoclonal antibody directed against the immune inhibitory receptor leukocyte + immunoglobulin-like receptor B4 (LILRB4), with potential immune checkpoint inhibitory + and antineoplastic activities. Upon administration, anti-LILRB4 monoclonal antibody + IO-202 targets, binds to and inhibits LILRB4 and its downstream signaling pathways. + This may restore immune function through the activation of T-cells and T-cell-mediated + immune responses against tumor cells, and inhibit tumor infiltration. LILRB4, + an immune inhibitory receptor normally expressed on monocytic cells and highly + expressed on monocytic acute myeloid leukemia (AML) cells, functions as an immune + checkpoint that negatively regulates T-cell activation as its extracellular + domain inhibits T-cell activity. It plays an important role in tumor infiltration + in leukemias through multiple signaling pathways. + termDef: + term: >- + Anti-LILRB4 Monoclonal Antibody IO-202 + source: NCIt + cde_id: C174485 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174485" + term_id: C174485 + term_version: 20.10d + +antimesothelinmmae_antibodydrug_conjugate_rc88: + common: + description: >- + An antibody-drug conjugate (ADC) composed of an antibody directed against the + human cell surface glycoprotein mesothelin and conjugated, via a cleavable linker, + to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), + with potential antineoplastic activity. Upon administration, the antibody moiety + of anti-mesothelin/MMAE ADC RC88 targets and binds to the tumor associated antigen + (TAA) mesothelin on the surface of tumor cells. Upon internalization and the + release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule + polymerization. This results in G2/M phase cell cycle arrest and apoptosis in + mesothelin-expressing tumor cells. Mesothelin is overexpressed by all mesotheliomas + and a variety of other cancers, while it is minimally expressed in normal tissue. + termDef: + term: >- + Anti-mesothelin/MMAE Antibody-drug Conjugate RC88 + source: NCIt + cde_id: C174395 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174395" + term_id: C174395 + term_version: 20.10d + +antimuc16cd3_bispecific_antibody_regn4018: + common: + description: >- + A bispecific, human monoclonal antibody with potential antineoplastic activity. + REGN4018 contains two antigen-recognition sites: one for human CD3, a T cell + surface antigen that is part of the T cell receptor complex, and one for human + mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303), a member of the mucin + family of glycoproteins that is overexpressed by several epithelial cancers, + including ovarian cancer. Upon administration, REGN4018 binds to both T-cells + and MUC16-expressing tumor cells, which cross-links the T-cells to the tumor + cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against + the MUC16-expressing tumor cells. + termDef: + term: >- + Anti-MUC16/CD3 Bispecific Antibody REGN4018 + source: NCIt + cde_id: C153129 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C153129" + term_id: C153129 + term_version: 20.10d + +antimuc17cd3_bite_antibody_amg_199: + common: + description: >- + A half-life extended (HLE), human bispecific T-cell engager (BiTE) antibody + composed of two single-chain variable fragments (scFv), one directed against + the tumor-associated antigen (TAA) human mucin 17 (MUC17), and one directed + against human CD3, a T-cell surface antigen found on T-lymphocytes, with potential + antineoplastic activity. Upon administration, anti-MUC17/CD3 BiTE antibody AMG + 199 binds to both CD3 on T-cells and MUC17 expressed on tumor cells. This results + in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic + T-lymphocyte (CTL) response against MUC17-expressing tumor cells. MUC17, a member + of the mucin family of glycoproteins, is overexpressed in a variety of tumor + cells of epithelial origin and plays a key role in tumor cell dissemination. + termDef: + term: >- + Anti-MUC17/CD3 BiTE Antibody AMG 199 + source: NCIt + cde_id: C165588 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165588" + term_id: C165588 + term_version: 20.10d + +antinapi2b_antibodydrug_conjugate_xmt1592: + common: + description: >- + An antibody-drug conjugate (ADC) composed of XMT-1535, a humanized monoclonal + antibody against human sodium-dependent phosphate transport protein 2B (SLC34A2; + NaPi2b), that is site-specifically bioconjugated to the cytotoxic aurastatin + derivative auristatin F-HPA (AF-HPA; auristatin F-hydroxypropylamide), with + potential antineoplastic activity. Upon administration of anti-NaPi2b ADC XMT-1592, + the antibody moiety targets and binds to NaPi2b expressed on tumor cells. Following + internalization of XMT-1592 and release of AF-HPA, the AF-HPA binds to tubulin + and inhibits microtubule polymerization, which results in G2/M phase arrest + and apoptosis of NaPi2b-expressing tumor cells. NaPi2b, a tumor-associated antigen + (TAA), is overexpressed on a variety of cancer cells and plays a key role in + the transport of inorganic phosphate (Pi) and the maintenance of phosphate homeostasis. + termDef: + term: >- + Anti-NaPi2b Antibody-drug Conjugate XMT-1592 + source: NCIt + cde_id: C173702 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173702" + term_id: C173702 + term_version: 20.10d + +antinrp1_antibody_asp1948: + common: + description: >- + A human immunoglobulin G4 (IgG4) monoclonal antibody directed against neuropilin-1 + (NRP1; CD304; BDCA-4), with potential immunomodulatory and antineoplastic activities. + Upon administration, anti-NRP1 antibody ASP1948 specifically targets and binds + to NRP1. This prevents the binding of NRP1 to its ligand and may block the immune + inhibitory actions of regulatory T-cells (Tregs) mediated by the interaction + of NRP1 with its ligand. This may enhance the immune response against tumor + cells. NRP1 is a transmembrane co-receptor protein expressed in Tregs; it plays + an important role in maintaining the stability and function of Tregs. + termDef: + term: >- + Anti-NRP1 Antibody ASP1948 + source: NCIt + cde_id: C156402 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156402" + term_id: C156402 + term_version: 20.10d + +antiox40_agonist_monoclonal_antibody_bgba445: + common: + description: >- + An agonistic monoclonal antibody targeting the co-stimulatory receptor OX40 + (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with + potential immunostimulatory and antineoplastic activities. Upon administration, + anti-OX40 agonist monoclonal antibody BGB-A445 selectively binds to OX40, thereby + activating OX40. This induces the proliferation of memory and effector T-lymphocytes + and results in a T-cell-mediated immune response against tumor cells, which + leads to tumor cell lysis. OX40, a cell surface glycoprotein and member of the + tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes + and provides a co-stimulatory signal that promotes both the proliferation and + survival of activated T-cells. + termDef: + term: >- + Anti-OX40 Agonist Monoclonal Antibody BGB-A445 + source: NCIt + cde_id: C175453 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175453" + term_id: C175453 + term_version: 20.10d + +antiox40_hexavalent_agonist_antibody_inbrx106: + common: + description: >- + An agonistic, recombinant, humanized, hexavalent immunoglobulin G (IgG) antibody + targeting the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor + superfamily member 4; TNFRSF4), with potential immunostimulatory and antineoplastic + activities. Upon administration, anti-OX40 hexavalent agonist antibody INBRX-106 + selectively binds to six OX40 receptors per molecule, thereby clustering and + activating OX40. This induces the proliferation of memory and effector T-lymphocytes + and results in a T-cell-mediated immune response against tumor cells, which + leads to tumor cell lysis. OX40, a cell surface glycoprotein and member of the + tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes + and provides a co-stimulatory signal that promotes both the proliferation and + survival of activated T-cells. Utilizing a hexavalent OX40 antibody may improve + receptor clustering and downstream signaling over tetravalent or bivalent OX40 + antibodies. + termDef: + term: >- + Anti-OX40 Hexavalent Agonist Antibody INBRX-106 + source: NCIt + cde_id: C173983 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173983" + term_id: C173983 + term_version: 20.10d + +antipd1_antibodyinterleukin21_mutein_fusion_protein_amg_256: + common: + description: >- + An antibody directed against the negative immunoregulatory human cell receptor + programmed cell death protein 1 (PD-1; PDCD1; CD279) fused to a mutein of the + cytokine interleukin-21 (IL-21), with potential immune checkpoint inhibitory, + immunomodulating and antineoplastic activities. Upon administration of anti-PD-1 + antibody-IL-21 mutein fusion protein AMG 256, the antibody moiety specifically + targets, binds to and inhibits PD-1 and its downstream signaling pathways. This + may restore immune function through the activation of T-cells and T-cell-mediated + immune responses against tumor cells. The IL-21 mutein moiety binds to the IL-21 + receptor and activates IL-21 cytokine signaling in PD-1-expressing cells. This + may modulate the proliferation and/or differentiation, promote survival, and + increase the cytolytic activity of PD-1-expressing T-cells, thereby enhancing + T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane + protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions + as an immune checkpoint that negatively regulates T-cell activation and effector + function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1; + cluster of differentiation 274; CD274) or 2 (PD-L2); it plays an important role + in tumor evasion from host immunity. IL-21 plays an important role in the regulation + of cellular immune responses. + termDef: + term: >- + Anti-PD-1 Antibody-interleukin-21 Mutein Fusion Protein AMG 256 + source: NCIt + cde_id: C174140 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174140" + term_id: C174140 + term_version: 20.10d + +antipd1_monoclonal_antibody_609a: + common: + description: >- + A recombinant immunoglobulin G4 (IgG4) kappa monoclonal antibody directed against + the negative immunoregulatory human cell receptor programmed cell death protein + 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic + activities. Upon administration, anti-PD-1 monoclonal antibody 609A targets, + binds to and inhibits PD-1 and its downstream signaling pathways. This may restore + immune function through the activation of T-cells and T-cell-mediated immune + responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin + superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that + negatively regulates T-cell activation and effector function when activated + by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays + an important role in tumor evasion from host immunity. + termDef: + term: >- + Anti-PD-1 Monoclonal Antibody 609A + source: NCIt + cde_id: C172820 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172820" + term_id: C172820 + term_version: 20.10d + +antipd1_monoclonal_antibody_scti10a: + common: + description: >- + A recombinant, humanized monoclonal antibody directed against the negative immunoregulatory + human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with + potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, + anti-PD-1 monoclonal antibody SCT-I10A targets, binds to, and inhibits PD-1 + and its downstream signaling pathways. This may restore immune functions through + the activation of T-cells and T-cell-mediated immune responses against tumor + cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) + expressed on T-cells, functions as an immune checkpoint that negatively regulates + T-cell activation and effector function when activated by its ligands programmed + cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor + evasion from host immunity. + termDef: + term: >- + Anti-PD-1 Monoclonal Antibody SCT-I10A + source: NCIt + cde_id: C170758 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170758" + term_id: C170758 + term_version: 20.10d + +antipd1antiher2_bispecific_antibody_ibi315: + common: + description: >- + A recombinant human immunoglobulin G1 (IgG1) bispecific antibody directed against + the human epidermal growth factor receptor 2 (HER2) and the negative immunoregulatory + human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with + potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, + the anti-PD-1/anti-HER2 bispecific antibody IBI315 simultaneously targets, binds + to and inhibits HER2 and PD-1 and their downstream signaling pathways, and bridges + PD-1-expressing T-cells to HER2-expressing tumor cells. This may inhibit tumor + cell proliferation of HER2-overexpressing cells. Inhibition of PD-1-mediated + signaling may restore immune function through the activation of T-cells and + T-cell-mediated immune responses against the HER2-expressing tumor cells. PD-1, + a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on + T-cells, functions as an immune checkpoint that negatively regulates T-cell + activation and effector function when activated by its ligands programmed cell + death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion + from host immunity. + termDef: + term: >- + Anti-PD-1/Anti-HER2 Bispecific Antibody IBI315 + source: NCIt + cde_id: C174419 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174419" + term_id: C174419 + term_version: 20.10d + +antipd1antilag3_bispecific_antibody_ro7247669: + common: + description: >- + A bispecific antibody directed against the human negative immunoregulatory checkpoint + receptors programmed cell death protein 1 (PD-1; PD1; PDCD1; CD279; Programmed + Death 1) and lymphocyte activation gene 3 protein (LAG-3; LAG3; CD223), with + potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, + anti-PD-1/anti-LAG-3 bispecific antibody RO7247669 targets and binds to both + PD-1 and LAG-3 expressed on T-cells and inhibits the PD-1- and LAG-3-mediated + downregulation of T-cell activation and proliferation. This may lead to cytotoxic + T-lymphocyte (CTL)-mediated immune response against tumor cells. PD-1 and LAG-3 + play key roles in suppressing T-cell activation and proliferation. + termDef: + term: >- + Anti-PD-1/Anti-LAG-3 Bispecific Antibody RO7247669 + source: NCIt + cde_id: C173539 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173539" + term_id: C173539 + term_version: 20.10d + +antipd1antipdl1_bispecific_antibody_ibi318: + common: + description: >- + A recombinant immunoglobulin G1 (IgG1) bispecific antibody targeting both the + human negative immunoregulatory checkpoint receptor programmed cell death protein + 1 (PD-1; PDCD1; CD279) and its ligand, human programmed death-ligand 1 (PD-L1; + CD274), with potential checkpoint inhibitory, immunostimulating and antineoplastic + activities. Upon administration, anti-PD-1/anti-PD-L1 bispecific antibody IBI318 + simultaneously targets and binds to PD-1, which is expressed on a variety of + leukocyte subsets including activated T-lymphocytes in the tumor microenvironment + (TME), and PD-L1, which is expressed on tumor cells. This crosslinks PD-1-expressing + T cells and PD-L1-expressing tumor cells. This prevents PD-L1 from binding to + and activating its receptor PD-1 and inhibits the PD-L1/PD-1-mediated downregulation + of T-cell activation and proliferation. This abrogates T-cell inhibition, activates + antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor + cell lysis, which may lead to a reduction in tumor growth. PD-L1 binding to + PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive + T-cells, suppresses the immune system and results in immune evasion. + termDef: + term: >- + Anti-PD-1/Anti-PD-L1 Bispecific Antibody IBI318 + source: NCIt + cde_id: C171938 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171938" + term_id: C171938 + term_version: 20.10d + +antipd1cd47_infusion_protein_hx009: + common: + description: >- + A bispecific antibody fusion protein directed against the human negative immunoregulatory + checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and + the human cell surface antigen CD47, with potential immunostimulating, phagocytosis-inducing + and antineoplastic activities. Upon administration of anti-PD-1/CD47 infusion + protein HX009, the agent simultaneously and selectively targets and binds to + PD-1 expressed on T-lymphocytes and CD47 on tumor cells. The CD47 binding by + HX009 blocks the interaction of CD47 with signal regulatory protein alpha (SIRPalpha), + an inhibitory protein expressed on macrophages and dendritic cells (DCs), which + prevents CD47/SIRPalpha-mediated signaling and abrogates the CD47/SIRPalpha-mediated + inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by + the binding of calreticulin (CRT), which is specifically expressed on the surface + of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), + expressed on macrophages, which results in macrophage activation and the specific + phagocytosis of the CD47-expressing tumor cells. The binding of HX009 to PD-1 + blocks the interaction between PD-1 and its ligands, PD-1 ligand 1 (PD-L1) and + PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream + signaling pathways. This may restore effector T-cell functions and may further + activate cytotoxic T-lymphocyte (CTL)-mediated tumor cell killing. CD47, also + called integrin-associated protein (IAP), is a tumor-associated antigen (TAA), + widely expressed on normal, healthy cells, such as red blood cells and platelets, + and overexpressed on the surface of a variety of cancer cells. Expression of + CD47, and its interaction with SIRPalpha, leads to the inhibition of macrophage + activation and protects cancer cells from phagocytosis, which allows cancer + cells to proliferate. By co-targeting CD47 and PD-1, HX009 has the potential + to overcome the limitations of existing CD47-targeted therapies by possibly + avoiding the side effects caused by binding to CD47 on healthy hematopoietic + stem cells (HSCs), which causes unwanted macrophage-mediated phagocytosis. PD-1, + an inhibitory receptor belonging to the immunoglobulin superfamily (IgSF), is + expressed on activated T-lymphocytes; it functions as an immune checkpoint that + negatively regulates T-cell activation and effector function when activated + by its ligands, and plays an important role in tumor evasion from host immunity. + termDef: + term: >- + Anti-PD-1/CD47 Infusion Protein HX009 + source: NCIt + cde_id: C168600 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168600" + term_id: C168600 + term_version: 20.10d + +antipd1ctla4_bispecific_antibody_medi5752: + common: + description: >- + An engineered fragment crystallizable (Fc) domain bispecific human immunoglobulin + G1 (IgG1) monoclonal antibody directed against the human negative immunoregulatory + checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and + cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + anti-PD1/CTLA4 bispecific antibody MEDI5752 targets and binds to both PD-1 and + CTLA4 expressed on tumor-infiltrating T lymphocytes (TILs), and inhibits the + PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. + In addition, MEDI5752 is internalized and is able to degrade PD-1. This restores + immune function and activates a sustained cytotoxic T-lymphocyte (CTL)-mediated + immune response against tumor cells. Both PD-1 and CTLA4 are selectively expressed + on TILs in the tumor microenvironment (TME) and negatively regulate the activation + and effector functions of T-cells. They play key roles in the downregulation + of the immune system and tumor evasion from host immunity. Dual checkpoint blockade + of PD1 and CTLA4 with MEDI5752 may enhance T-cell activation and proliferation + more than the blockade of either immune checkpoint receptor alone. It may also + decrease toxicity by avoiding the binding to CTLA-4-expressing T-cells that + are devoid of PD-1. The engineered Fc domain may reduce Fc effector function. + termDef: + term: >- + Anti-PD-1/CTLA-4 Bispecific Antibody MEDI5752 + source: NCIt + cde_id: C171937 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171937" + term_id: C171937 + term_version: 20.10d + +antipd1vegf_bispecific_antibody_ak112: + common: + description: >- + A bispecific antibody directed against the negative immunoregulatory human cell + receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and the human + vascular endothelial growth factor (VEGF), with potential immune checkpoint + inhibitory, anti-angiogenic and antineoplastic activities. Upon administration + of anti-PD-1/VEGF bispecific antibody AK112, this agent simultaneously targets + and binds to both PD-1 expressed on certain T-cells and VEGF. The binding of + AK112 to PD-1 prevents the activation of PD-1 by its ligands, programmed cell + death-1 ligand 1 (PD-L1) and/or 2 (PD-L2). This abrogates T-cell inhibition, + activates antigen-specific T-lymphocytes and enhances cytotoxic T-lymphocyte + (CTL)-mediated tumor cell lysis, which may lead to a reduction in tumor growth. + The binding of AK112 to VEGF prevents binding of VEGF to its receptor VEGFR, + abrogates VEGF/VEGFR-mediated signaling and may lead to the inhibition of vascular + endothelial cell proliferation. The inhibition of tumor angiogenesis may further + decrease tumor cell proliferation and prevent metastasis. PD-1, a transmembrane + protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions + as an immune checkpoint that negatively regulates T-cell activation and effector + function when activated by its ligands PD-L1/ or PD-L2; it plays an important + role in tumor evasion from host immunity. VEGF is overexpressed in a variety + of cancers and is associated with increased invasiveness and decreased survival. + termDef: + term: >- + Anti-PD-1/VEGF Bispecific Antibody AK112 + source: NCIt + cde_id: C170909 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170909" + term_id: C170909 + term_version: 20.10d + +antipdl1_monoclonal_antibody_imc001: + common: + description: >- + A human monoclonal antibody directed against the immunosuppressive ligand programmed + cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + anti-PD-L1 monoclonal antibody IMC-001 specifically targets and binds to PD-L1, + blocking its binding to and activation of its receptor programmed cell death + 1 (PD-1; cluster of differentiation 279; CD279). This reverses T-cell inactivation + caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated + anti-tumor immune response against PD-L1-expressing tumor cells. In addition, + anti-PD-L1 monoclonal antibody IMC-001 also induces antibody-dependent cell-mediated + cytotoxicity (ADCC). PD-L1 is overexpressed by many human cancer cell types. + PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in + immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin + superfamily (IgSF) expressed on activated T-cells, is a negative regulator of + the immune system that limits the expansion and survival of CD8-positive T-cells. + termDef: + term: >- + Anti-PD-L1 Monoclonal Antibody IMC-001 + source: NCIt + cde_id: C172819 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172819" + term_id: C172819 + term_version: 20.10d + +antipdl1_monoclonal_antibody_rc98: + common: + description: >- + A monoclonal antibody directed against the immunosuppressive ligand programmed + cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + anti-PD-L1 monoclonal antibody RC98 specifically targets and binds to PD-L1, + blocking its binding to and activation of its receptor programmed cell death + 1 (PD-1; cluster of differentiation 279; CD279). This reverses T-cell inactivation + caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated + anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed + by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses + the immune system and results in immune evasion. PD-1, a transmembrane protein + belonging to the immunoglobulin superfamily (IgSF) expressed on activated T-cells, + is a negative regulator of the immune system that limits the expansion and survival + of CD8-positive T-cells. + termDef: + term: >- + Anti-PD-L1 Monoclonal Antibody RC98 + source: NCIt + cde_id: C174520 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174520" + term_id: C174520 + term_version: 20.10d + +antipdl1anti41bb_bispecific_monoclonal_antibody_gen1046: + common: + description: >- + A recombinant, Fc-silenced immunoglobulin G1 (IgG1) bispecific antibody targeting + both the human programmed death-ligand 1 (PD-L1) and 4-1BB (CD137; tumor necrosis + factor receptor superfamily member 9; TNFRSF9), with potential checkpoint inhibitory, + immunostimulating and antineoplastic activities. Upon administration, anti-PD-L1/4-1BB + bispecific antibody GEN1046 simultaneously targets and binds to 4-1BB, which + is expressed on a variety of leukocyte subsets including activated T-lymphocytes, + and PD-L1 expressed on tumor cells. Through 4-1BB binding, GEN1046 acts as a + conditional 4-1BB agonist, resulting in T-cell co-stimulation and enhances T-lymphocyte-mediated + anti-tumor activity. At the same time,GEN1046 prevents PD-L1 from binding to + and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed + death-1). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes + and enhances cytotoxic T-cell-mediated tumor cell lysis, which may lead to a + reduction in tumor growth. PD-L1 binding to PD-1 on activated T-cells inhibits + the expansion and survival of CD8-positive T-cells, suppresses the immune system + and results in immune evasion. 4-1BB, a surface glycoprotein of the tumor necrosis + factor receptor superfamily, is an inducible costimulatory receptor that plays + a key role in T-cell proliferation, survival and cytolytic activity. + termDef: + term: >- + Anti-PD-L1/Anti-4-1BB Bispecific Monoclonal Antibody GEN1046 + source: NCIt + cde_id: C172194 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172194" + term_id: C172194 + term_version: 20.10d + +antipdl1il15_fusion_protein_kd033: + common: + description: >- + A fusion protein composed of a monoclonal antibody directed against the immunosuppressive + ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; + CD274) fused to the immunostimulatory cytokine interleukin-15 (IL-15), with + potential immunostimulatory and antineoplastic activities. Upon administration + of the anti-PD-L1/IL-15 fusion protein KD033, the anti-PD-L1 antibody moiety + specifically targets and binds to PD-L1 expressing cells in the tumor microenvironment + (TME). In turn, IL-15 stimulates the proliferation of natural killer (NK) cells, + cytotoxic T-lymphocytes (CTLs) and memory T-cells locally in the TME, which + induces an anti-tumor immune response. This may increase tumor cell killing + and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, + activation and proliferation. PD-L1, a transmembrane protein, is expressed on + the surface of antigen presenting cells (APCs) and on many cancer cell types. + PD-L1 binding to PD-1, a negative regulator of the immune system on activated + T-cells, limits the expansion and survival of CD8-positive T-cells, suppresses + the immune system and results in immune evasion. + termDef: + term: >- + Anti-PD-L1/IL-15 Fusion Protein KD033 + source: NCIt + cde_id: C173592 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173592" + term_id: C173592 + term_version: 20.10d + +antiprame_tcell_receptoranticd3_scfv_fusion_protein_imcf106c: + common: + description: >- + A T-cell re-directing bi-specific biologic composed of a modified form of human + T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially + expressed antigen in melanoma (PRAME) and fused to an anti-CD3 single-chain + variable fragment (scFv), with potential antineoplastic activity. Upon administration + of IMC-F106C, the TCR moiety of this agent targets and binds to PRAME on tumor + cells and the anti-CD3 scFv moiety binds to CD3- expressing T-lymphocytes. This + selectively cross-links tumor cells and T-lymphocytes and results in a CTL-mediated + death of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety + of cancer cell types. + termDef: + term: >- + Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C + source: NCIt + cde_id: C170976 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170976" + term_id: C170976 + term_version: 20.10d + +antipsmacd3_bispecific_antibody_ccw702: + common: + description: >- + A bispecific antibody that targets both the tumor-associated antigen (TAA) human + prostate-specific membrane antigen (PSMA) and the CD3 antigen found on T-lymphocytes, + with potential immunostimulatory and antineoplastic activities. Upon administration + of anti-PSMA/CD3 bispecific antibody CCW702, this bispecific antibody binds + to both CD3 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing + tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, + which results in the CTL-mediated cell death of PSMA-expressing tumor cells. + PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate + cancer cells. + termDef: + term: >- + Anti-PSMA/CD3 Bispecific Antibody CCW702 + source: NCIt + cde_id: C169053 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C169053" + term_id: C169053 + term_version: 20.10d + +antirankl_monoclonal_antibody_gb223: + common: + description: >- + A monoclonal antibody directed against the receptor activator of nuclear factor + kappa beta ligand (RANKL) with potential antiosteoclast and antineoplastic activities. + Upon administration, anti-RANKL monoclonal antibody GB-223 specifically binds + to RANKL and blocks the interaction of RANKL with RANK, a receptor located on + osteoclast cell surfaces. This results in the inhibition of osteoclast activity, + a decrease in bone resorption, and a potential increase in bone mineral density. + By blocking the activation of the RANK/RANKL-mediated signaling pathway, GB-223 + may also reduce tumor-associated bone destruction and may result in tumor regression + in bone tumors with high RANK and RANKL expressions. RANKL, a protein expressed + by osteoblastic cells, plays an important role in osteoclastic differentiation + and activation. Both RANKL and RANK are overexpressed in certain bone tumors, + and the RANK/RANKL-mediated signaling pathway plays an important role in certain + bone tumors. + termDef: + term: >- + Anti-RANKL Monoclonal Antibody GB-223 + source: NCIt + cde_id: C174406 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174406" + term_id: C174406 + term_version: 20.10d + +antirankl_monoclonal_antibody_jmt103: + common: + description: >- + A recombinant, human, immunoglobulin G4 (IgG4) monoclonal antibody directed + against the receptor activator of nuclear factor kappa beta ligand (RANKL), + with potential antiosteoclast and bone-sparing activities. Upon administration, + anti-RANKL monoclonal antibody JMT103 specifically binds to RANKL and blocks + the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces. + This may inhibit osteoclast activity, decrease bone resorption, increase bone + mineral density, and may protect bones from tumor metastasis. This may abrogate + hypercalcemia of malignancy and may correct serum calcium levels. RANKL, a protein + expressed by osteoblastic cells, plays an important role in osteoclastic differentiation + and activation. Both RANKL and RANK are overexpressed in certain bone tumors, + and the RANK/RANKL-mediated signaling pathway plays an important role in certain + bone tumors. + termDef: + term: >- + Anti-RANKL Monoclonal Antibody JMT103 + source: NCIt + cde_id: C175441 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175441" + term_id: C175441 + term_version: 20.10d + +antiribonucleoprotein_antibody_atrc101: + common: + description: >- + An engineered, human immunoglobulin (Ig) G1 monoclonal antibody directed against + a ribonucleoprotein (RNP) complex, with potential immunostimulating and antineoplastic + activities. Upon administration, anti-RNP antibody ATRC-101 targets and binds + to its RNP complex antigen on tumor cells. This may activate the innate immune + system, change the local tumor microenvironment (TME) and promote T cell-mediated + killing of tumor cells. The tumor-restricted RNP complex is expressed in a variety + of tumor cells. + termDef: + term: >- + Anti-Ribonucleoprotein Antibody ATRC-101 + source: NCIt + cde_id: C172924 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172924" + term_id: C172924 + term_version: 20.10d + +antiror1pnu159682_derivative_antibodydrug_conjugate_nbe002: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody + against the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan + receptor 1 (ROR1) site-specifically conjugated to a derivative of the highly + potent anthracycline PNU-159682, with potential antineoplastic activity. Upon + intravenous administration, the monoclonal antibody moiety of NBE-002 targets + and binds to ROR1 expressed on tumor cells. Upon binding and internalization, + the anthracycline-based toxin intercalates into DNA and interacts with topoisomerase + II. This leads to an inhibition of DNA replication and repair, and prevents + RNA and protein synthesis. This kills the ROR1-expressing cancer cells. In addition, + the PNU-159682 derivate may promote immunogenic cell death (ICD) and activate + a cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response, thereby + further killing the ROR1-expressing tumor cells. ROR1, also known as neurotrophic + tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis + and by certain leukemias. It plays key roles in tumor cell proliferation and + survival. + termDef: + term: >- + Anti-ROR1/PNU-159682 Derivative Antibody-drug Conjugate NBE-002 + source: NCIt + cde_id: C174012 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174012" + term_id: C174012 + term_version: 20.10d + +antisense_oligonucleotide_qr313: + common: + description: >- + A twenty-one nucleotide-containing antisense oligonucleotide (AON) with potential + use in the treatment of recessive dystrophic epidermolysis bullosa (RDEB) due + to mutations in exon 73 of the COL7A1 gene. Upon topical administration, QR-313 + hybridizes to a specific sequence in COL7A1 pre-mRNA, resulting in exclusion + of exon 73 from mRNA and translation of a functional type VII collagen protein. + This may restore functionality of integument anchoring fibrils, prevent blistering, + and improve wound healing in patients with DEB. Type VII collagen is a major + component of anchoring fibrils, attachment structures that mediate dermal-epidermal + adherence in human skin. DEB is an inherited mechano-bullous disorder caused + by mutations in the COL7A1 gene, which lead to perturbations in anchoring fibrils. + termDef: + term: >- + Antisense Oligonucleotide QR-313 + source: NCIt + cde_id: C162452 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C162452" + term_id: C162452 + term_version: 20.10d + +antitigit_monoclonal_antibody_bgba1217: + common: + description: >- + A humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting the co-inhibitory + molecule and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin + (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), + with potential immune checkpoint inhibitory activity. Upon administration, anti-TIGIT + monoclonal antibody BGB-A1217 targets and binds to TIGIT expressed on various + immune cells, particularly on tumor-infiltrating T-lymphocytes (TILs), thereby + preventing the interaction of TIGIT with its ligands CD112 (nectin-2; poliovirus + receptor related-2; PRR2; PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like + protein 5; NECL-5). This enhances the interaction of CD112 and CD155 with the + costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1), which is expressed + on immune cells, such as natural killer (NK) cells and CD8+ T-cells. This leads + to CD226 dimerization and CD226-mediated signaling and activates the immune + system to exert a T-cell-mediated immune response against cancer cells. TIGIT, + a member of the Ig super family (IgSF) and an immune inhibitory receptor, plays + a key role in the suppression of T-cell proliferation and activation; it is + involved in tumor cell immune evasion, and the inhibition of antiviral immune + responses. + termDef: + term: >- + Anti-TIGIT Monoclonal Antibody BGB-A1217 + source: NCIt + cde_id: C170906 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170906" + term_id: C170906 + term_version: 20.10d + +antitigit_monoclonal_antibody_com902: + common: + description: >- + A fully human monoclonal antibody targeting the co-inhibitory molecule and immune + checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor + tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential immune + checkpoint inhibitory activity. Upon administration, anti-TIGIT monoclonal antibody + COM902 targets and binds to TIGIT expressed on various immune cells, particularly + on tumor-infiltrating lymphocytes (TILs), thereby preventing the interaction + of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2; PRR2; + PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5). + This enhances the interaction of CD112 and CD155 with the costimulatory receptor + CD226 (DNAX Accessory molecule-1; DNAM-1), which is expressed on immune cells, + such as natural killer (NK) cells and CD8+ T-cells. This leads to CD226 dimerization + and CD226-mediated signaling and activates the immune system to exert a T-cell-mediated + immune response against cancer cells. TIGIT, a member of the Ig super family + (IgSF) and an immune inhibitory receptor, plays a key role in the suppression + of T-cell proliferation and activation; it is involved in tumor cell immune + evasion, and the inhibition of antiviral immune responses. + termDef: + term: >- + Anti-TIGIT Monoclonal Antibody COM902 + source: NCIt + cde_id: C174037 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174037" + term_id: C174037 + term_version: 20.10d + +antitigit_monoclonal_antibody_sgntgt: + common: + description: >- + A nonfucosylated human immunoglobulin G1 (IgG1) monoclonal antibody targeting + the co-inhibitory molecule and immune checkpoint inhibitor T-cell immunoreceptor + with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif + (ITIM) domains (TIGIT), with potential immune checkpoint inhibitory activity. + Upon administration, anti-TIGIT monoclonal antibody SGN-TGT targets and binds + to TIGIT expressed on various immune cells, particularly on tumor-infiltrating + T-lymphocytes (TILs). This prevents the interaction of TIGIT with its ligands + CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2) and CD155 (poliovirus + receptor; PVR; nectin-like protein 5; NECL-5), and enhances the interaction + of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; + DNAM-1), which is expressed on immune cells, such as natural killer (NK) cells + and CD8+ T-cells. This enhances depletion of TIGIT-positive regulatory T-cells + (Tregs) and activates the immune system to exert a T-cell-mediated immune response + against cancer cells. TIGIT, a member of the Ig super family (IgSF) and an immune + inhibitory receptor, plays a key role in the suppression of T-cell proliferation + and activation; it is involved in tumor cell immune evasion, and the inhibition + of antiviral immune responses. + termDef: + term: >- + Anti-TIGIT Monoclonal Antibody SGN-TGT + source: NCIt + cde_id: C173630 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173630" + term_id: C173630 + term_version: 20.10d + +antitim3_monoclonal_antibody_shr1702: + common: + description: >- + A monoclonal antibody against the inhibitory T-cell receptor, T-cell immunoglobulin + and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular + receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic + activities. Upon administration, anti-TIM3 monoclonal antibody SHR-1702 targets + and binds to TIM-3 expressed on certain T-cells, including tumor infiltrating + lymphocytes (TILs). This abrogates T-cell inhibition, activates antigen-specific + T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which + results in a reduction in tumor growth. TIM-3, a transmembrane protein and immune + checkpoint receptor, is associated with tumor-mediated immune suppression. + termDef: + term: >- + Anti-TIM3 Monoclonal Antibody SHR-1702 + source: NCIt + cde_id: C172108 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172108" + term_id: C172108 + term_version: 20.10d + +antitrailr2cdh17_tetravalent_bispecific_antibody_bi_905711: + common: + description: >- + A tetravalent bispecific antibody targeting both the pro-apoptotic death receptor + tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor + 2 (TRAILR2; death receptor 5; DR5) and cadherin-17 (CDH17), with potential pro-apoptotic + and antineoplastic activities. Upon administration of anti-TRAILR2/CDH17 tetravalent + bispecific antibody BI 905711, the antibody targets and binds to both TRAILR2 + and CDH17, expressed on tumor cells. Receptor clustering and activation of TRAILR2 + induces apoptosis in CDH17-positive cancer cells. Activation of TRAILR2 plays + a key role in the induction of apoptosis. CDH17-dependent clustering of TRAILR2 + allows BI 905711 to selectively induce apoptosis in CDH17-expressing tumor cells + thereby increasing efficacy and decreasing liver toxicity. CDH17 is overexpressed + in a variety of cancer cell types while its expression is restricted in normal + liver tissue. + termDef: + term: >- + Anti-TRAILR2/CDH17 Tetravalent Bispecific Antibody BI 905711 + source: NCIt + cde_id: C173541 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173541" + term_id: C173541 + term_version: 20.10d + +antitrop2_antibodydrug_conjugate_bat8003: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a monoclonal antibody against tumor-associated + antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium + signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated via an + uncleavable linker to an as of yet undisclosed maytansine derivative toxin, + with potential antineoplastic activity. Upon administration of the anti-TROP2 + ADC BAT8003, the anti-TROP2 antibody targets and binds to TROP2 expressed on + tumor cells. Upon cellular uptake, the cytotoxic maytansine derivative binds + to tubulin, thereby affecting microtubule assembly and disassembly dynamics. + This inhibits tumor cell proliferation of TROP2-expressing tumor cells. TROP2 + is a transmembrane protein overexpressed in various tumors. Its expression is + associated with enhanced tumor aggressiveness, metastasis, drug resistance and + increased tumor cell survival. + termDef: + term: >- + Anti-TROP2 Antibody-drug Conjugate BAT8003 + source: NCIt + cde_id: C172060 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172060" + term_id: C172060 + term_version: 20.10d + +antitrop2_antibodydrug_conjugate_skb264: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a monoclonal antibody against tumor-associated + antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium + signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated to an + as of yet undisclosed toxin, with potential antineoplastic activity. Upon administration + of the anti-TROP2 ADC SKB264, the anti-TROP2 antibody targets and binds to TROP2 + expressed on tumor cells. Upon cellular uptake, the undisclosed toxin exerts, + through an as of yet not disclosed mechanism of action, its cytotoxic effect. + This inhibits tumor cell proliferation of TROP2-expressing tumor cells. TROP2 + is a transmembrane protein overexpressed in various tumors while its expression + is low and/or restricted in normal, healthy tissues; its expression is associated + with enhanced tumor aggressiveness, metastasis, drug resistance and increased + tumor cell survival. + termDef: + term: >- + Anti-TROP2 Antibody-drug Conjugate SKB264 + source: NCIt + cde_id: C166409 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166409" + term_id: C166409 + term_version: 20.10d + +antivegfr2_monoclonal_antibody_msb0254: + common: + description: >- + A humanized monoclonal antibody directed against human vascular endothelial + growth factor receptor 2 (VEGFR-2; VEGFR2) with potential anti-angiogenesis + and antineoplastic activities. Upon administration, anti-VEGFR2 monoclonal antibody + MSB0254 specifically binds to and inhibits VEGFR2, which may inhibit tumor angiogenesis + and tumor cell proliferation. VEGFR2, a tyrosine-protein kinase that plays an + essential role in angiogenesis and the proliferation, survival, migration and + differentiation of endothelial cells, is overexpressed in certain tumor types. + termDef: + term: >- + Anti-VEGFR2 Monoclonal Antibody MSB0254 + source: NCIt + cde_id: C174422 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174422" + term_id: C174422 + term_version: 20.10d + +anus_nos: + common: + description: >- + The lower opening of the digestive tract, lying in the cleft between the buttocks, + through which fecal matter is extruded. + termDef: + term: >- + Anus + source: NCIt + cde_id: C43362 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43362" + term_id: C43362 + term_version: 20.05a + +aortic_body_paraganglioma: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma that arises + from paraganglia adjacent to the base of the heart and great vessels. + termDef: + term: >- + Aorticopulmonary Paraganglioma + source: NCIt + cde_id: C4218 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4218" + term_id: C4218 + term_version: 20.05a + +aortic_body_tumor: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma that arises + from paraganglia adjacent to the base of the heart and great vessels. + termDef: + term: >- + Aorticopulmonary Paraganglioma + source: NCIt + cde_id: C4218 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4218" + term_id: C4218 + term_version: 20.05a + +aorticopulmonary_paraganglioma: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma that arises + from paraganglia adjacent to the base of the heart and great vessels. + termDef: + term: >- + Aorticopulmonary Paraganglioma + source: NCIt + cde_id: C4218 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4218" + term_id: C4218 + term_version: 20.05a + +apc: + common: + description: >- + This gene plays a role in signal transduction. It is involved in both adhesion + and migration of cells. + termDef: + term: >- + APC Gene + source: NCIt + cde_id: C17567 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17567" + term_id: C17567 + term_version: 20.10d + +apobec3b: + common: + description: >- + This gene plays a role in viral DNA cytosine deamination. + termDef: + term: >- + APOBEC3B Gene + source: NCIt + cde_id: C117001 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C117001" + term_id: C117001 + term_version: 20.10d + +apocrine_adenoma: + common: + description: >- + A benign epithelial neoplasm arising from the apocrine sweat glands. Representative + examples include tubular apocrine adenoma and external auditory canal ceruminous + adenoma. + termDef: + term: >- + Apocrine Adenoma + source: NCIt + cde_id: C4168 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4168" + term_id: C4168 + term_version: 20.05a + +apocrine_cystadenoma: + common: + description: >- + A slow-growing, usually solitary, dome-shaped benign sweat gland adenoma, most + frequently located on the eyelid. It is characterized by a cystic proliferation + of apocrine glands. Surgical excision is curative. + termDef: + term: >- + Apocrine Hidrocystoma + source: NCIt + cde_id: C43342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43342" + term_id: C43342 + term_version: 20.05a + +appendix: + common: + description: >- + Small tissue projection existing as a cecal diverticulum with a questionable + history of vestigial versus specialized organ. + termDef: + term: >- + Appendix + source: NCIt + cde_id: C12380 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12380" + term_id: C12380 + term_version: 20.05a + +aprinocarsen: + common: + description: >- + A synthetic phosphorothioate oligodeoxynucleotide. As an antisense molecule, + aprinocarsen hybridizes to the 3-untranslated region of the human protein kinase + C (PKC-alpha) mRNA, thereby inhibiting PKC-alpha expression and growth of PKC-alpha-dependent + tumor cells. (NCI04) + termDef: + term: >- + Aprinocarsen + source: NCIt + cde_id: C1788 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1788" + term_id: C1788 + term_version: 20.10d + +aprutumab: + common: + description: >- + An antibody against the fibroblast growth factor receptor type 2 (FGFR2), with + potential antineoplastic activity. Upon administration, aprutumab binds to and + inhibits FGFR2, which may result in the inhibition of both FGFR2 phosphorylation + and FGFR2-mediated signal transduction pathways. This results in the inhibition + of cell proliferation and the induction of cell death of FGFR2-expressing tumor + cells. FGFR2, upregulated in many tumor cell types, is a receptor tyrosine kinase, + which is essential to tumor cellular proliferation, differentiation and survival. + termDef: + term: >- + Aprutumab + source: NCIt + cde_id: C107683 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107683" + term_id: C107683 + term_version: 20.10d + +apudoma: + common: + description: >- + A tumor made up of cells with APUD properties. + termDef: + term: >- + Neoplasm of the Diffuse Neuroendocrine System + source: NCIt + cde_id: C2879 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2879" + term_id: C2879 + term_version: 20.05a + +ar: + common: + description: >- + This gene plays a role in the transcriptional activation of androgen responsive + genes. + termDef: + term: >- + AR Gene + source: NCIt + cde_id: C28539 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28539" + term_id: C28539 + term_version: 20.10d + +araf: + common: + description: >- + This gene plays a role in signal transduction and the cellular response to mitogens. + termDef: + term: >- + ARAF Gene + source: NCIt + cde_id: C18354 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18354" + term_id: C18354 + term_version: 20.10d + +argentina: + common: + description: >- + A country in southern South America, bordering the South Atlantic Ocean, between + Chile and Uruguay. + termDef: + term: >- + Argentina + source: NCIt + cde_id: C16305 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16305" + term_id: C16305 + term_version: 19.12e + +arhgap26: + common: + description: >- + This gene plays a role in signal transduction. + termDef: + term: >- + ARHGAP26 Gene + source: NCIt + cde_id: C97504 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97504" + term_id: C97504 + term_version: 20.10d + +arhgap5: + common: + description: >- + This gene is involved in the regulation of GTPase activity. + termDef: + term: >- + ARHGAP5 Gene + source: NCIt + cde_id: C97279 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97279" + term_id: C97279 + term_version: 20.10d + +arhgef12: + common: + description: >- + This gene plays a role in both G-protein coupled receptor- and Rho-mediated + signaling. + termDef: + term: >- + ARHGEF12 Gene + source: NCIt + cde_id: C97436 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97436" + term_id: C97436 + term_version: 20.10d + +arid1a: + common: + description: >- + This gene plays a role in transcriptional regulation. + termDef: + term: >- + ARID1A Gene + source: NCIt + cde_id: C92530 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92530" + term_id: C92530 + term_version: 20.10d + +arid1b: + common: + description: >- + This gene plays a role in both chromatin remodeling and transcriptional regulation. + termDef: + term: >- + ARID1B Gene + source: NCIt + cde_id: C102520 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102520" + term_id: C102520 + term_version: 20.10d + +arid2: + common: + description: >- + This gene is involved in both transcriptional regulation and chromatin remodeling. + termDef: + term: >- + ARID2 Gene + source: NCIt + cde_id: C101088 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101088" + term_id: C101088 + term_version: 20.10d + +armenia: + common: + description: >- + A country in southwestern Asia, east of Turkey and south of Georgia. + termDef: + term: >- + Armenia + source: NCIt + cde_id: C16306 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16306" + term_id: C16306 + term_version: 19.12e + +arnt: + common: + description: >- + This gene is involved in xenobiotic metabolism and receptor-ligand mediated + interactions. + termDef: + term: >- + ARNT Gene + source: NCIt + cde_id: C26373 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26373" + term_id: C26373 + term_version: 20.10d + +arrhenoblastoma_benign: + common: + description: >- + A Sertoli cell tumor of the testis or the ovary which remains localized and + does not metastasize to another anatomic site. + termDef: + term: >- + Benign Sertoli Cell Tumor + source: NCIt + cde_id: C67012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67012" + term_id: C67012 + term_version: 20.05a + +arrhenoblastoma_malignant: + common: + description: >- + A Sertoli cell tumor that arises from the testis or the ovary. It is characterized + by nuclear pleomorphism, increased mitotic activity and necrotic changes. Metastases + may be present at diagnosis. + termDef: + term: >- + Malignant Sertoli Cell Tumor + source: NCIt + cde_id: C67006 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67006" + term_id: C67006 + term_version: 20.05a + +arrhenoblastoma_nos: + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +arteriovenous_hemangioma: + common: + description: >- + A benign vascular lesion characterized by the presence of a complex network + of communicating arterial and venous vascular structures. + termDef: + term: >- + Arteriovenous Hemangioma/Malformation + source: NCIt + cde_id: C2882 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2882" + term_id: C2882 + term_version: 20.05a + +aruba: + common: + description: >- + An island in the Caribbean Sea, north of Venezuela and west of Curacao. + termDef: + term: >- + Aruba + source: NCIt + cde_id: C17884 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17884" + term_id: C17884 + term_version: 19.12e + +aryl_hydrocarbon_receptor_inhibitor_ik175: + common: + description: >- + An orally bioavailable selective inhibitor of the aryl hydrocarbon receptor + (AhR; class E basic helix-loop-helix protein 76; bHLHe76), with potential immunomodulating + and antineoplastic activities. Upon oral administration, AhR inhibitor IK-175 + specifically targets and binds to AhR, inhibits AhR activation, prevents AhR-mediated + signaling, and AhR-dependent tumor cell proliferation. Abrogation of AhR activation + prevents the activation of immune-tolerant dendritic cells (DCs), regulatory + T-cells (Tregs) and decreases suppressive cytokines in the tumor microenvironment + (TME). It stimulates cytotoxic T-cell activation and expansion. This may restore + the immune response against tumor cells. AhR, a member of the basic helix-loop-helix/Per-Arnt-Sim + (bHLH/PAS) family of transcription factors, plays key roles in regulating immunity + and cellular differentiation. It mediates the expression of multiple immune + related and tumor cell signal transduction and proliferation genes. + termDef: + term: >- + Aryl Hydrocarbon Receptor Inhibitor IK-175 + source: NCIt + cde_id: C171151 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171151" + term_id: C171151 + term_version: 20.10d + +ascending_colon: + common: + description: >- + The first part of the colon (large intestine) that starts in the right lower + quadrant of the abdomen and ends at the transverse colon in the right upper + quadrant of the abdomen. + termDef: + term: >- + Ascending Colon + source: NCIt + cde_id: C12265 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12265" + term_id: C12265 + term_version: 20.05a + +ascites: + common: + description: >- + The accumulation of fluid in the peritoneal cavity, which may be serous, hemorrhagic, + or the result of tumor metastasis to the peritoneum. + termDef: + term: >- + Ascites + source: NCIt + cde_id: C2885 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2885" + term_id: C2885 + term_version: 20.05a + +asian: + common: + description: >- + A person having origins in any of the original peoples of the Far East, Southeast + Asia, or the Indian subcontinent, including for example, Cambodia, China, India, + Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. + (OMB) + termDef: + term: >- + Asian + source: NCIt + cde_id: C41260 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C41260" + term_id: C41260 + term_version: 19.12e + +askin_tumor: + common: + description: >- + A primitive neuroectodermal tumor (small round blue cell tumor) of the thorax + which can involve the periosteum, thoracic wall and/or pleura though it spares + the lung parenchyma. + termDef: + term: >- + Askin Tumor + source: NCIt + cde_id: C7542 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7542" + term_id: C7542 + term_version: 20.05a + +aspacytarabine: + common: + description: >- + A small molecule pro-drug consisting of cytarabine, an antimetabolite analog + of cytidine with a modified arabinose sugar moiety, covalently bonded to asparagine, + with potential antineoplastic activity. Upon intravenous administration, aspacytarabine + targets cancer cells, which often lack asparagine synthetase and are dependent + on an external source of amino acids due to their high metabolic rate. Once + the prodrug is inside target cells, the cytarabine component is cleaved and + competes with cytidine for incorporation into DNA. The arabinose sugar moiety + of cytarabine sterically hinders the rotation of the molecule within DNA, resulting + in cell cycle arrest, specifically during the S phase of replication. Cytarabine + also inhibits DNA polymerase, resulting in a decrease in DNA replication and + repair. Because BST-236 specifically targets cancer cells, it may spare normal + tissues from cytarabine-related toxicities. + termDef: + term: >- + Aspacytarabine + source: NCIt + cde_id: C153327 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C153327" + term_id: C153327 + term_version: 20.10d + +aspscr1: + common: + description: >- + This gene is involved in the modulation of blood glucose levels. + termDef: + term: >- + ASPSCR1 Gene + source: NCIt + cde_id: C70991 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70991" + term_id: C70991 + term_version: 20.10d + +astroblastoma: + common: + description: >- + A rare glial neoplasm more commonly found in young adults. It is characterized + by tumor cells with characteristics suggestive of an astrocytic origin (positive + for GFAP), arranged perivascularly. The cells have broad, non-tapering processes + radiating towards a central blood vessel. The biologic behavior of astroblastomas + is variable, so no WHO grade has been established, yet. (Adapted from WHO.) + termDef: + term: >- + Astroblastoma + source: NCIt + cde_id: C4324 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4324" + term_id: C4324 + term_version: 20.05a + +astrocytic_glioma: + common: + description: >- + A glial tumor of the brain or spinal cord showing astrocytic differentiation. It + includes the following clinicopathological entities: pilocytic astrocytoma, + diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, + subependymal giant cell astrocytoma, and glioblastoma. + termDef: + term: >- + Astrocytic Tumor + source: NCIt + cde_id: C6958 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6958" + term_id: C6958 + term_version: 20.05a + +astrocytoma_anaplastic: + common: + description: >- + A diffusely infiltrating, WHO grade III astrocytoma with focal or dispersed + anaplasia, and a marked proliferative potential. It may arise from a low-grade + astrocytoma, but it can also be diagnosed at first biopsy, without indication + of a less malignant precursor lesion. It has an intrinsic tendency for malignant + progression to glioblastoma. (WHO) + termDef: + term: >- + Anaplastic Astrocytoma + source: NCIt + cde_id: C9477 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9477" + term_id: C9477 + term_version: 20.05a + +astrocytoma_low_grade: + common: + description: >- + A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse + infiltration of neighboring central nervous system structures. These lesions + typically affect young adults and have a tendency for progression to anaplastic + astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse + astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified. + termDef: + term: >- + Diffuse Astrocytoma + source: NCIt + cde_id: C7173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7173" + term_id: C7173 + term_version: 20.05a + +astrocytoma_nos: + common: + description: >- + A tumor of the brain or spinal cord showing astrocytic differentiation. It includes + the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, + anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant + cell astrocytoma. + termDef: + term: >- + Astrocytoma + source: NCIt + cde_id: C60781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C60781" + term_id: C60781 + term_version: 20.05a + +astroglioma: + common: + description: >- + A glial tumor of the brain or spinal cord showing astrocytic differentiation. It + includes the following clinicopathological entities: pilocytic astrocytoma, + diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, + subependymal giant cell astrocytoma, and glioblastoma. + termDef: + term: >- + Astrocytic Tumor + source: NCIt + cde_id: C6958 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6958" + term_id: C6958 + term_version: 20.05a + +asunercept: + common: + description: >- + A human, soluble fusion protein consisting of the extracellular domain of the + CD95 receptor fused to the Fc-domain of the human IgG antibody, with potential + antineoplastic activity. Upon administration, asunercept binds to the CD95 ligand + (CD95L) and blocks the binding of CD95L to the CD95 receptor. In tumor cells, + blockage of CD95L-mediated signaling pathways may prevent cell migration and + invasive cell growth; in healthy cells, blockage of CD95L-mediated signaling + pathways may prevent apoptosis and may protect cell damage. Activation of the + CD95 receptor plays an important role in the initiation of apoptosis in healthy + cells or the invasive growth of cancer cells. + termDef: + term: >- + Asunercept + source: NCIt + cde_id: C90562 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C90562" + term_id: C90562 + term_version: 20.10d + +asxl1: + common: + description: >- + This gene may be involved in both transcriptional regulation and chromatin remodeling. + termDef: + term: >- + ASXL1 Gene + source: NCIt + cde_id: C97320 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97320" + term_id: C97320 + term_version: 20.10d + +asxl2: + common: + description: >- + This gene plays a role in both chromatin modification and the positive regulation + of transcription. + termDef: + term: >- + ASXL2 Gene + source: NCIt + cde_id: C116296 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116296" + term_id: C116296 + term_version: 20.10d + +atf1: + common: + description: >- + This gene is involved in the modulation of transcription. + termDef: + term: >- + ATF1 Gene + source: NCIt + cde_id: C92177 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92177" + term_id: C92177 + term_version: 20.10d + +atic: + common: + description: >- + This gene plays a role in purine biosynthesis. + termDef: + term: >- + ATIC Gene + source: NCIt + cde_id: C97400 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97400" + term_id: C97400 + term_version: 20.10d + +atm: + common: + description: >- + This gene is involved in apoptosis, DNA repair and cell cycle regulation. + termDef: + term: >- + ATM Gene + source: NCIt + cde_id: C18583 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18583" + term_id: C18583 + term_version: 20.10d + +atp1a1: + common: + description: >- + This gene is involved in both ion transport and ATP metabolism. + termDef: + term: >- + ATP1A1 Gene + source: NCIt + cde_id: C113762 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113762" + term_id: C113762 + term_version: 20.10d + +atp2b3: + common: + description: >- + This gene plays a role in ATP-dependent calcium transport. + termDef: + term: >- + ATP2B3 Gene + source: NCIt + cde_id: C113765 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113765" + term_id: C113765 + term_version: 20.10d + +atr: + common: + description: >- + This gene is involved in cell cycle checkpoints and DNA recombination. + termDef: + term: >- + ATR Gene + source: NCIt + cde_id: C20560 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20560" + term_id: C20560 + term_version: 20.10d + +atr_inhibitor_rp3500: + common: + description: >- + An orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) + kinase, with potential antineoplastic activity. Upon oral administration, ATR + inhibitor RP-3500 selectively targets and inhibits ATR activity and blocks the + downstream phosphorylation of the serine/threonine protein kinase checkpoint + kinase 1 (CHK1). This prevents ATR-mediated signaling, which results in the + inhibition of DNA damage checkpoint activation, the disruption of DNA damage + repair, and the induction of tumor cell apoptosis. ATR, a serine/threonine protein + kinase upregulated in a variety of cancer cell types, plays a key role in DNA + repair, cell cycle progression and survival. It is activated by DNA damage caused + during DNA replication-associated stress. + termDef: + term: >- + ATR Inhibitor RP-3500 + source: NCIt + cde_id: C174206 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174206" + term_id: C174206 + term_version: 20.10d + +atr_kinase_inhibitor_m1774: + common: + description: >- + An orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) + kinase, with potential antineoplastic activity. Upon oral administration, ATR + kinase inhibitor M1774 selectively inhibits ATR activity and blocks the downstream + phosphorylation of the serine/threonine protein kinase checkpoint kinase 1 (CHK1). + This prevents ATR-mediated signaling, which results in the inhibition of DNA + damage checkpoint activation, the disruption of DNA damage repair, and the induction + of tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated + in a variety of cancer cell types, plays a key role in DNA repair, cell cycle + progression and survival. It is activated by DNA damage caused during DNA replication-associated + stress. + termDef: + term: >- + ATR Kinase Inhibitor M1774 + source: NCIt + cde_id: C171067 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171067" + term_id: C171067 + term_version: 20.10d + +atrx: + common: + description: >- + This gene plays a role in the regulation of both chromatin remodeling and transcription. + termDef: + term: >- + ATRX Gene + source: NCIt + cde_id: C74976 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74976" + term_id: C74976 + term_version: 20.10d + +attenuated_measles_virus_encoding_scd_transgene_tmv018: + common: + description: >- + A recombinant, attenuated oncolytic measles virus (MV) encoding the prodrug + converting enzyme super cytosine deaminase (SCD), that can potentially be used + as an antineoplastic adjuvant and with potential antineoplastic activity. Upon + intra-tumoral injection, TMV-018 preferentially enters and transfects tumor + cells, and expresses SCD, an enzyme that catalyzes the intracellular conversion + of the prodrug flucytosine (5-fluorocytosine; 5-FC) into the antineoplastic + agent 5-fluorouracil (5-FU). After administration of 5-FC, the tumor can be + eradicated upon activation of 5-FU by SCD. In addition, the oncolytic MV may + infect and lyse tumor cells. In turn, the lysed tumor cells release various + tumor-associated antigens (TAAs), which induce an immune response against the + tumor cells. This may further eradicate tumor cells. + termDef: + term: >- + Attenuated Measles Virus Encoding SCD Transgene TMV-018 + source: NCIt + cde_id: C175440 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175440" + term_id: C175440 + term_version: 20.10d + +atuveciclib: + common: + description: >- + An inhibitor of positive transcription elongation factor b (P-TEFb), which is + composed of cyclin-dependent kinase 9 (CDK9) and cyclin-T (CycT), with potential + antineoplastic activity. Upon administration, atuveciclib binds to and inhibits + the activity of P-TEFb, thereby preventing the phosphorylation of its downstream + target, the carboxyl terminal domain (CTD) of RNA polymerase II (RNA Pol II), + and inhibiting the activation of transcriptional elongation by RNA Pol II. This + prevents the transcription of tumor promoting genes, induces tumor cell apoptosis, + and inhibits tumor cell proliferation. P-TEFb plays an important role in the + regulation of gene transcription; over-activation in cancer cells leads to both + the transcription of key tumor-promoting genes and cancer cell proliferation. + termDef: + term: >- + Atuveciclib + source: NCIt + cde_id: C121456 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121456" + term_id: C121456 + term_version: 20.10d + +atypical: + common: + description: >- + Cytologic Atypia + termDef: + term: >- + Cytologic Atypia + source: NCIt + cde_id: C8326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8326" + term_id: C8326 + term_version: 20.05a + +atypical_adenoma: + common: + description: >- + An adenoma characterized by increased cellularity and nuclear atypia without + evidence of vascular or capsular invasion. A representative example is thyroid + gland atypical follicular adenoma. + termDef: + term: >- + Atypical Adenoma + source: NCIt + cde_id: C7559 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7559" + term_id: C7559 + term_version: 20.05a + +atypical_carcinoid_tumor: + common: + description: >- + A carcinoid tumor characterized by a high mitotic rate, often associated with + the presence of necrosis and nuclear pleomorphism. + termDef: + term: >- + Atypical Carcinoid Tumor + source: NCIt + cde_id: C72074 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C72074" + term_id: C72074 + term_version: 20.05a + +atypical_choroid_plexus_papilloma: + common: + description: >- + A choroid plexus papilloma characterized by increased mitotic activity. + termDef: + term: >- + Atypical Choroid Plexus Papilloma + source: NCIt + cde_id: C53686 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53686" + term_id: C53686 + term_version: 20.05a + +atypical_chronic_myeloid_leukemia_bcrabl_negative: + common: + description: >- + Myelogenous leukemia that is negative for Philadelphia chromosome. + termDef: + term: >- + Philadelphia-Negative Myelogenous Leukemia + source: NCIt + cde_id: C3176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3176" + term_id: C3176 + term_version: 20.05a + +atypical_chronic_myeloid_leukemia_philadelphia_chromosome_ph1_negative: + common: + description: >- + Myelogenous leukemia that is negative for Philadelphia chromosome. + termDef: + term: >- + Philadelphia-Negative Myelogenous Leukemia + source: NCIt + cde_id: C3176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3176" + term_id: C3176 + term_version: 20.05a + +atypical_fibrous_histiocytoma: + common: + description: >- + An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, + usually affecting the actinic-damaged skin of the elderly. The tumor presents + as a single cutaneous nodule which is often ulcerated. Microscopically, it + is characterized by the presence of highly atypical cytologic features, pleomorphism + and abundant mitotic figures. The vast majority of patients have an excellent + prognosis following conservative therapy. Recurrences are infrequent, and metastasis + is rare. + termDef: + term: >- + Atypical Fibroxanthoma + source: NCIt + cde_id: C4246 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4246" + term_id: C4246 + term_version: 20.05a + +atypical_fibroxanthoma: + common: + description: >- + An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, + usually affecting the actinic-damaged skin of the elderly. The tumor presents + as a single cutaneous nodule which is often ulcerated. Microscopically, it + is characterized by the presence of highly atypical cytologic features, pleomorphism + and abundant mitotic figures. The vast majority of patients have an excellent + prognosis following conservative therapy. Recurrences are infrequent, and metastasis + is rare. + termDef: + term: >- + Atypical Fibroxanthoma + source: NCIt + cde_id: C4246 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4246" + term_id: C4246 + term_version: 20.05a + +atypical_follicular_adenoma: + common: + description: >- + An encapsulated or well-circumscribed tumor composed of well-differentiated + follicular cells with well-developed or partially developed nuclear features + of papillary thyroid carcinoma and with questionable capsular or vascular invasion. + That is this is a tumor indeterminate between follicular adenoma and follicular + carcinoma. Tumors in which vascular invasion has been excluded by all means + are called non-invasive follicular thyroid neoplasms with papillary-like nuclear + features. (WHO 2017) + termDef: + term: >- + Thyroid Gland Well-Differentiated Tumor of Uncertain Malignant Potential + source: NCIt + cde_id: C27729 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27729" + term_id: C27729 + term_version: 20.05a + +atypical_leiomyoma: + common: + description: >- + A morphologic variant of leiomyoma characterized by the presence of pleomorphic + muscle cells with bizarre hyperchromatic nuclei and eosinophilic cytoplasm. + termDef: + term: >- + Bizarre Leiomyoma + source: NCIt + cde_id: C4257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4257" + term_id: C4257 + term_version: 20.05a + +atypical_lipoma: + common: + description: >- + An intermediate, locally aggressive lipomatous neoplasm. Microscopically, the + adipose tissue contains large and pleomorphic lipoblasts, and is dissected by + fibrous septa containing spindle cells. It requires a wide local excision, + may recur locally, but never metastasizes. + termDef: + term: >- + Atypical Lipomatous Tumor + source: NCIt + cde_id: C6505 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6505" + term_id: C6505 + term_version: 20.05a + +atypical_meningioma: + common: + description: >- + A WHO grade II meningioma characterized by the presence of brain invasion and + an increased mitotic activity, or at least three of the following morphologic + features: small cells, high cellularity, prominent nucleoli, lack of architectural + pattern, and necrosis. + termDef: + term: >- + Atypical Meningioma + source: NCIt + cde_id: C4723 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4723" + term_id: C4723 + term_version: 20.05a + +atypical_polypoid_adenomyoma: + common: + description: >- + An adenomyoma characterized by the presence of marked glandular architectural + complexity. + termDef: + term: >- + Atypical Polypoid Adenomyoma + source: NCIt + cde_id: C6895 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6895" + term_id: C6895 + term_version: 20.05a + +atypical_proliferating_serous_tumor: + common: + description: >- + A serous cystic glandular epithelial neoplasm of low malignant potential. It + is characterized by the presence of atypical or malignant glandular epithelial + cells with an absence of stromal invasion. + termDef: + term: >- + Borderline Serous Cystadenoma + source: NCIt + cde_id: C4177 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4177" + term_id: C4177 + term_version: 20.05a + +atypical_proliferative_endometrioid_tumor: + common: + description: >- + An epithelial neoplasm that arises from the ovary characterized by the presence + of glandular or cystic spaces which contain atypical glandular epithelial cells + resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. + There is no evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid + Tumor + source: NCIt + cde_id: C7983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7983" + term_id: C7983 + term_version: 20.05a + +atypical_proliferative_papillary_serous_tumor: + common: + description: >- + A low malignant potential cystic serous epithelial neoplasm arising from the + ovary. Cases with identical morphology have been described arising from the + peritoneum as well. It is characterized by an atypical epithelial proliferation + and a papillary growth pattern. There is no evidence of destructive stromal + invasion. + termDef: + term: >- + Borderline Papillary Serous Cystadenoma + source: NCIt + cde_id: C4183 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4183" + term_id: C4183 + term_version: 20.05a + +atypical_teratoidrhabdoid_tumor: + common: + description: >- + An aggressive malignant embryonal neoplasm arising from the central nervous + system. It is composed of cells with a large eccentric nucleus, prominent nucleolus, + and abundant cytoplasm. Mutations of the INI1 gene or very rarely SMARCA4 (BRG1) + gene are present. The vast majority of cases occur in childhood. Symptoms include + lethargy, vomiting, cranial nerve palsy, headache, and hemiplegia. + termDef: + term: >- + Atypical Teratoid/Rhabdoid Tumor + source: NCIt + cde_id: C6906 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6906" + term_id: C6906 + term_version: 20.05a + +audencel: + common: + description: >- + A therapeutic interleukin-12 (IL-12)-expressing dendritic cell (DC)-based vaccine + composed of autologous monocyte-derived DCs loaded with autologous tumor cell + lysate and exposed to the microbial cell wall component lipopolysaccharide (LPS), + with potential immunomodulating and antineoplastic activities. The monocyte-derived + immature DCs are loaded with autologous tumor cell lysates and are subsequently + exposed to LPS and interferon-gamma (IFN-gamma). Upon administration of audencel, + the mature DCs migrate into the lymph nodes, express the immune stimulatory + cytokine interleukin-12 (IL-12) and activate the immune system by promoting + the activation of natural killer (NK) cells and induce a cytotoxic T-lymphocyte + (CTL)-mediated immune response against tumor cells, which may result in immune-mediated + tumor cell death and inhibition of tumor cell proliferation. Exposure to LPS + and IFN-gamma allows the maturation of DCs and optimizes the presentation of + tumor-associated antigens (TAAs) by DCs to T-lymphocytes. + termDef: + term: >- + Audencel + source: NCIt + cde_id: C123928 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123928" + term_id: C123928 + term_version: 20.10d + +aunt: + common: + description: >- + The sister of your father or mother; the wife of your uncle. + termDef: + term: >- + Aunt + source: NCIt + cde_id: C71405 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71405" + term_id: C71405 + term_version: 19.12e + +australia: + common: + description: >- + The continent and country between the Indian Ocean and the South Pacific Ocean, + south of Asia. + termDef: + term: >- + Australia + source: NCIt + cde_id: C16311 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16311" + term_id: C16311 + term_version: 19.12e + +austria: + common: + description: >- + A country in central Europe, northeast of Italy and southeast of Germany. + termDef: + term: >- + Austria + source: NCIt + cde_id: C16312 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16312" + term_id: C16312 + term_version: 19.12e + +autologous_afp_specific_t_cell_receptor_transduced_t_cells_ctcr055: + common: + description: >- + A preparation of human autologous T-lymphocytes transduced with a lentiviral + vector encoding for a T-cell receptor (TCR) recognizing the human leukocyte + antigen (HLA)-A*02:01 restricted human alpha-fetoprotein (AFP) 158-166 peptide + (FMNKFIYEI), with potential antineoplastic activity. Upon isolation, transduction, + expansion ex vivo, and reintroduction into the patient, the AFP specific TCR + transduced T cells recognize and bind to AFP antigen-positive cells, which results + in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a + variety of cancers while its expression is restricted in normal tissues. + termDef: + term: >- + Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055 + source: NCIt + cde_id: C173429 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173429" + term_id: C173429 + term_version: 20.10d + +autologous_antibcma_car_tcells_phe885: + common: + description: >- + A preparation of autologous T-lymphocytes that have been genetically engineered + to express a chimeric antigen receptor (CAR) targeting the human tumor-associated + antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor + superfamily member 17; TNFRSF17), with potential antineoplastic activity. Upon + administration, the autologous anti-BCMA CAR T-cells PHE885 recognize and induce + selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific + antigen and a receptor for both a proliferation-inducing ligand (APRIL) and + B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor + superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found + on the surfaces of plasma cells and is overexpressed on malignant plasma cells. + termDef: + term: >- + Autologous Anti-BCMA CAR T-cells PHE885 + source: NCIt + cde_id: C174124 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174124" + term_id: C174124 + term_version: 20.10d + +autologous_antibcma_cd8_car_tcells_descartes11: + common: + description: >- + A preparation of autologous CD8-positive T-lymphocytes that have been genetically + modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated + antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor + superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic + activities. Upon administration, autologous anti-BCMA CD8+ CAR T-cells Descartes-11 + specifically recognize and induce selective toxicity in BCMA-expressing tumor + cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing + ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor + necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma + cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed + on malignant plasma cells. + termDef: + term: >- + Autologous Anti-BCMA CD8+ CAR T-cells Descartes-11 + source: NCIt + cde_id: C173434 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173434" + term_id: C173434 + term_version: 20.10d + +autologous_antibcmacar41bbcd3zetaexpressing_tcells_ccar088: + common: + description: >- + A preparation of autologous T-lymphocytes that have been transduced with a vector + expressing a chimeric antigen receptor (CAR) containing a single chain variable + fragment (scFv) specific for the epitome cluster E3 in the extracellular domain + (ECD) of the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; + tumor necrosis factor receptor superfamily member 17; TNFRSF17) that is fused + to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling + domain of CD3zeta (CD3z), with potential immunostimulating and antineoplastic + activities. Upon administration, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing + T-cells C-CAR088 specifically recognize and induce selective toxicity in BCMA-expressing + tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing + ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor + necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival + of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells + and is overexpressed on malignant plasma cells. + termDef: + term: >- + Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088 + source: NCIt + cde_id: C170747 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170747" + term_id: C170747 + term_version: 20.10d + +autologous_anticd123_cart_cells: + common: + description: >- + A preparation of autologous T-cells engineered to express a chimeric antigen + receptor (CAR) specific for the tumor-associated antigen (TAA) CD123 (interleukin-3 + receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic + activities. Upon administration, the autologous anti-CD123 CAR-T cells target + and bind to CD123 expressed on the surface of tumor cells. This induces selective + toxicity in CD123-expressing tumor cells. CD123, the alpha subunit of the IL-3 + receptor, regulates the proliferation, survival and differentiation of hematopoietic + cells. It is overexpressed on a variety of cancers, including myeloid leukemia, + and the increased expression of CD123 on leukemic stem cells (LSCs) is associated + with poor prognosis. + termDef: + term: >- + Autologous Anti-CD123 CAR-T Cells + source: NCIt + cde_id: C171167 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171167" + term_id: C171167 + term_version: 20.10d + +autologous_anticd19_car_tcells_19t228z1xx: + common: + description: >- + A preparation of autologous T-lymphocytes that have been genetically modified + to express a chimeric antigen receptor (CAR) targeting the tumor-associated + antigen (TAA) CD19, and linked to the co-stimulatory intracellular signaling + domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta; + CD28z), with potential immunostimulating and antineoplastic activities. Upon + administration, the autologous anti-CD19 CAR T-cells 19(T2)28z1xx specifically + recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated + tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which + is expressed in all B-cell lineage malignancies and normal B-cells. CD28 and + CD3zeta provide co-stimulatory activity and may enhance the cytotoxic effect + and anti-tumor activity of the CAR T-cells. The 19(T2)28z1xx CAR T-cells include + a 1928zeta mutant, 1xx, which contains one instead of all three immunoreceptor + tyrosine-based activation motifs (iTAMs). This may help prevent counterproductive + T-cell differentiation and exhaustion. + termDef: + term: >- + Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx + source: NCIt + cde_id: C173622 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173622" + term_id: C173622 + term_version: 20.10d + +autologous_anticd19_car41bbcd3zetaexpressing_tcells_cnct19: + common: + description: >- + A preparation of autologous T-lymphocytes that are engineered to express a chimeric + antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) + single chain variable fragment (scFv) linked to the intracellular signaling + domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; + CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. + Upon administration, the autologous anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells + CNCT19 target, bind to and induce selective toxicity in CD19-expressing tumor + cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all + B-cell lineage malignancies. + termDef: + term: >- + Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19 + source: NCIt + cde_id: C175465 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175465" + term_id: C175465 + term_version: 20.10d + +autologous_anticd19_chimeric_antigen_receptor_tcells_auto1: + common: + description: >- + A preparation of autologous T-lymphocytes that have been genetically modified + and transduced with a lentiviral vector expressing a second-generation chimeric + antigen receptor (CAR), CAT-41BBz CAR, targeting the tumor-associated antigen + (TAA) CD19, with potential immunostimulating and antineoplastic activities. + Upon administration, autologous anti-CD19 CAR T-cells AUTO1 target and bind + to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) + response against CD19-expressing tumor cells and tumor cell lysis. CD19, cluster + of differentiation 19, is a B-cell-specific cell surface antigen overexpressed + in B-cell lineage tumors. The CAT-41BBz CAR has a faster off-rate compared with + FMC63-41BBz CAR. This may minimize cytokine release and reduce toxicities, and + enhance persistence of the CAR T-cells. + termDef: + term: >- + Autologous Anti-CD19 Chimeric Antigen Receptor T-cells AUTO1 + source: NCIt + cde_id: C172746 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172746" + term_id: C172746 + term_version: 20.10d + +autologous_anticd19_tact_cells_tac01cd19: + common: + description: >- + A preparation of autologous T-lymphocytes genetically engineered with a T cell + Antigen Coupler (TAC), comprising of a domain that targets the tumor-associated + antigen (TAA) cluster of differentiation 19 (CD 19) and another domain that + binds to the endogenous T cell receptor (TCR), anchored in the membrane via + the CD4 co-receptor domain, with potential immunostimulating and antineoplastic + activities. Upon administration, autologous anti-CD19 TAC-T cells TAC01-CD19 + targets and binds to CD19-expressing tumor cells and activates TCR-mediated + signaling pathways, leading to T cell-mediated killing of CD19-expressing tumor + cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed + in B-cell lineage malignancies. + termDef: + term: >- + Autologous Anti-CD19 TAC-T cells TAC01-CD19 + source: NCIt + cde_id: C172055 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172055" + term_id: C172055 + term_version: 20.10d + +autologous_anticd19carher2tcd22caregfrtexpressing_tcells: + common: + description: >- + A preparation of autologous human T-lymphocytes engineered to express dual chimeric + antigen receptors (CARs) consisting of both anti-CD19 and anti-CD22 binding + domains, fused to an as of yet undisclosed co-stimulatory domain, and linked + to truncated forms of the human epidermal growth factor receptor 2 (HER2t) and + the human epidermal growth factor receptor (EGFRt), respectively with potential + immunostimulating and antineoplastic activities. Upon administration, the autologous + anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells bind to CD19 and CD22 on + the surface of, and induce selective toxicity against tumor cells expressing + CD19 and CD22. Devoid of both ligand binding domains and tyrosine kinase activity, + the expressed EGFRt and HER2t facilitate both in vivo detection of the administered, + transduced T-cells and can promote elimination of those cells through an antibody-dependent + cellular cytotoxicity (ADCC) response. CD19 and CD22, both transmembrane phosphoglycoproteins + expressed on the surface of cells in the B lineage, are often overexpressed + on malignant B-cells. + termDef: + term: >- + Autologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells + source: NCIt + cde_id: C155897 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155897" + term_id: C155897 + term_version: 20.10d + +autologous_anticd19cd20_bispecific_nanobodybased_cart_cells: + common: + description: >- + A preparation of autologous T-lymphocytes engineered to express a chimeric antigen + receptor (CAR) that is nanobody-based and specific for the two tumor-associated + antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, with potential + immunostimulating and antineoplastic activities. Upon administration, the autologous + anti-CD19/CD20 bispecific nanobody-based CAR-T cells target and bind to CD19- + and CD20-expressing tumor B-cells. This induces selective toxicity in tumor + B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell surface + antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and + CD20 may prevent tumor cell antigen escape and relapse. + termDef: + term: >- + Autologous Anti-CD19/CD20 Bispecific Nanobody-based CAR-T cells + source: NCIt + cde_id: C172057 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172057" + term_id: C172057 + term_version: 20.10d + +autologous_anticd20_car_transduced_cd4cd8_enriched_tcells_mbcart201: + common: + description: >- + A preparation of autologous T-lymphocytes that have been genetically modified + to express a chimeric antigen receptor (CAR) targeting the tumor-associated + antigen (TAA) CD20 (cluster of differentiation 20), and CD4/CD8 enriched, with + potential immunostimulating and antineoplastic activities. Upon administration, + MB-CART20.1 specifically recognize and kill CD20-expressing tumor cells. The + CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific + cell surface antigen expressed in B-cell lineage malignancies and certain melanoma + cell subpopulations. + termDef: + term: >- + Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1 + source: NCIt + cde_id: C172063 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172063" + term_id: C172063 + term_version: 20.10d + +autologous_antiegfr_cartransduced_cxcr_5modified_tlymphocytes: + common: + description: >- + A preparation of autologous, C-X-C chemokine receptor type 5 (CXCR 5)-modified + T-lymphocytes that have been genetically modified to express a chimeric antigen + receptor (CAR) targeting the epidermal growth factor receptor (EGFR), with potential + immunostimulating and antineoplastic activities. Upon administration, the autologous + anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes target and bind to EGFR-expressing + tumor cells, thereby inducing selective toxicity in EGFR-expressing tumor cells. + EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor + cell proliferation, tumor angiogenesis and radio- and chemoresistance. CXCR5, + and its ligand C-X-C motif chemokine 13 (CXCL13), are associated with a variety + of tumors. CXCR5-CXCL13 interactions may be involved in the regulation of lymphocyte + infiltration within the tumor microenvironment (TME). + termDef: + term: >- + Autologous Anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes + source: NCIt + cde_id: C173958 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173958" + term_id: C173958 + term_version: 20.10d + +autologous_antiflt3_car_t_cells_amg_553: + common: + description: >- + A preparation of autologous T-lymphocytes genetically engineered with a chimeric + antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine + kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic + activities. Upon administration, the anti-FLT3 CAR T cells AMG 553 target and + bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte + (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III + receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage + neoplasms and in acute myeloid leukemias (AMLs). + termDef: + term: >- + Autologous Anti-FLT3 CAR T Cells AMG 553 + source: NCIt + cde_id: C172197 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172197" + term_id: C172197 + term_version: 20.10d + +autologous_antiicam1carcd2841bbcd3zetaexpressing_tcells_aic100: + common: + description: >- + A preparation of autologous T-lymphocytes that have been transduced with a lentiviral + vector to express a chimeric antigen receptor (CAR) containing the Inserted + (I) domain variant of lymphocyte function-associated antigen-1 (LFA-1) which + targets intercellular adhesion molecule-1 (ICAM-1 or CD54), and the co-stimulatory + signaling domains of CD28, 4-1BB (CD137) and CD3zeta, with potential immunostimulating + and antineoplastic activities. Upon administration, autologous anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing + T-cells AIC100 recognize and kill ICAM-1-expressing tumor cells. ICAM-1, normally + expressed on leukocytes and endothelial cells, may be overexpressed in a variety + of cancers. CAR T-cells AIC100 are also engineered to express somatostatin receptor + subtype 2 (SSTR2), allowing the imaging of the CAR T-cells in patients. + termDef: + term: >- + Autologous Anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T-cells AIC100 + source: NCIt + cde_id: C173378 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173378" + term_id: C173378 + term_version: 20.10d + +autologous_antikappa_light_chain_carcd28expressing_tlymphocytes: + common: + description: >- + A preparation of autologous T-lymphocytes (ATL) that have been genetically modified + to express a chimeric antigen receptor (CAR) directed against the kappa light + chain of immunoglobulin (Ig) and linked to the costimulatory domain of CD28, + with potential immunostimulating and antineoplastic activities. Upon administration, + the autologous anti-kappa light chain CAR-CD28-expressing T-lymphocytes target + and bind to the kappa light chain of Ig expressed on tumor cells, resulting + in T-cell-mediated tumor cell lysis. In some B-cell malignancies, the expression + of the Ig light chain kappa may be increased compared to the expression of Ig + light chain lambda. + termDef: + term: >- + Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes + source: NCIt + cde_id: C175446 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175446" + term_id: C175446 + term_version: 20.10d + +autologous_antipd1_antibodyactivated_tumorinfiltrating_lymphocytes: + common: + description: >- + A preparation of autologous tumor infiltrating lymphocytes (TILs) activated + by an anti-programmed cell death protein 1 (PD1) antibody, with potential immunomodulating + activity. The autologous TILs are isolated from an autologous tumor sample and + ex-vivo activated in the presence of anti-PD-1 antibody. Upon infusion of the + autologous anti-PD1 antibody-activated TILs back into the patient, the cells + specifically target and kill the patient's tumor cells. + termDef: + term: >- + Autologous Anti-PD-1 Antibody-activated Tumor-infiltrating Lymphocytes + source: NCIt + cde_id: C172191 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172191" + term_id: C172191 + term_version: 20.10d + +autologous_antipsma_cart_cells_ppsma101: + common: + description: >- + A preparation of autologous T-cells that are enriched to be primarily stem memory + T-cells (Tscm) and are transfected by electroporation with a proprietary transposon-based + DNA plasmid vector (PiggyBac), encoding both a chimeric antigen receptor (CAR) + based on a proprietary non-immunoglobulin scaffold molecule Centyrin (CARTyrin), + which specifically recognizes the tumor-associated antigen (TAA) prostate-specific + membrane antigen (PSMA), and a human-derived safety switch that can be activated + by rimiducid, with potential immunostimulating and antineoplastic activities. + Upon administration, autologous anti-PSMA CAR-T cells P-PSMA-101 specifically + recognize and induce selective toxicity in PSMA-expressing tumor cells. Use + of CARTyrin may elicit less immunotoxicity than CAR T-cells based on antibody-derived + single chain variable fragments (scFv), and may allow for increased persistence + and decreased exhaustion for the administered T-cells. If significant side effects + occur, the safety switch mechanism can be activated by the administration of + rimiducid, which results in the rapid attenuation or elimination of P-PSMA-101. + PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate + cancer cells. + termDef: + term: >- + Autologous Anti-PSMA CAR-T Cells P-PSMA-101 + source: NCIt + cde_id: C175511 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175511" + term_id: C175511 + term_version: 20.10d + +autologous_bcmatargeted_car_t_cells_cc98633: + common: + description: >- + A preparation of autologous T-lymphocytes that have been genetically modified + to express a chimeric antigen receptor (CAR) specific for the B-cell maturation + antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), + with potential immunostimulating and antineoplastic activities. Upon administration, + autologous BCMA-targeted CAR T cells CC-98633 specifically recognize and kill + BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for + both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), + is a member of the tumor necrosis factor (TNF) receptor superfamily and plays + a key role in plasma cell survival; it is found on the surfaces of plasma cells + and overexpressed on malignant plasma cells. + termDef: + term: >- + Autologous BCMA-targeted CAR T Cells CC-98633 + source: NCIt + cde_id: C173699 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173699" + term_id: C173699 + term_version: 20.10d + +autologous_bispecific_bcmacd19targeted_cart_cells_gc012f: + common: + description: >- + A preparation of autologous T-lymphocytes engineered to express two separate + chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) + BCMA and CD19 and fused to as of yet not fully elucidated co-stimulatory domains, + with potential immunostimulating and antineoplastic activities. Upon administration, + the autologous bispecific BCMA/CD19-targeted CAR-T cells GC012F specifically + and simultaneously target and bind to tumor cells expressing BCMA and/or CD19. + This induces selective toxicity in tumor cells that express BCMA and/or CD19. + BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing + ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor + necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival + of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells + and is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell + surface antigen overexpressed in B-cell lineage malignancies. The processing + platform used, FasT CAR-T, shortens the manufacturing time to produce the CAR-T + cells within 24 hours. + termDef: + term: >- + Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F + source: NCIt + cde_id: C175471 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175471" + term_id: C175471 + term_version: 20.10d + +autologous_bispecific_cd19cd22targeted_cart_cells_gc022: + common: + description: >- + A preparation of autologous human T-lymphocytes engineered to express chimeric + T-cell receptors (chimeric antigen receptors or CARs) targeting the tumor-associated + antigens (TAAs) CD19 and CD22 and fused to as of yet not fully elucidated co-stimulatory + domains, with potential immunostimulating and antineoplastic activities. Upon + administration, the autologous bispecific CD19/CD22-targeted CAR-T cells GC022 + bind to CD19 and CD22 on the surface of, and induce selective toxicity against, + tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins + expressed on the surface of cells in the B lineage, are overexpressed on malignant + B-cells. + termDef: + term: >- + Autologous Bispecific CD19/CD22-targeted CAR-T Cells GC022 + source: NCIt + cde_id: C171093 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171093" + term_id: C171093 + term_version: 20.10d + +autologous_cd19_carexpressing_cd4cd8_tcells_mbcart191: + common: + description: >- + A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with the + lentiviral vector pLTG1563 expressing a chimeric antigen receptor (CAR) specific + for the tumor-associated antigen (TAA) CD19, with potential immunostimulating + and antineoplastic activities. Upon intravenous administration, the autologous + CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1 are directed to and induce + selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell + specific cell surface antigen expressed in all B-cell lineage malignancies. + termDef: + term: >- + Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1 + source: NCIt + cde_id: C172103 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172103" + term_id: C172103 + term_version: 20.10d + +autologous_cd19pd1_bispecific_cart_cells: + common: + description: >- + A preparation of autologous T-lymphocytes that are transduced with a lentiviral + vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated + antigen (TAA) cluster of differentiation 19 (CD19) and a programmed cell death + protein 1 (PD1)/CD28 chimera, with potential immunomodulating and antineoplastic + activities. Upon reintroduction into the patient, the autologous CD19/PD-1 bispecific + CAR-T cells target and bind to CD19 and the PD-1 ligands, programmed cell death + ligand 1 (PD-L1) and 2 (PD-L2), expressed on tumor cells. The binding to CD19 + leads to a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor + cells and cell lysis of these cells. The binding of the PD1/CD28 chimera to + PD-L1 prevents the normal PD1/PD-L1-mediated T-cell suppression and, instead, + promotes signaling through the CD28 domain, which results in the stimulation + of T-lymphocytes. This enhances T-lymphocyte proliferation and anti-tumor activity. + CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell + lineage malignancies. PD-1 protein, found on activated T-cells, negatively regulates + T-cell activity. It plays a key role in immune evasion and prevents tumor cell + lysis. The construct of the PD1/CD28 chimera converts PD-L1 into a co-stimulation + ligand of primary human CD8+ cytotoxic T-lymphocytes (CTLs). CD28 is a costimulatory + molecule expressed by T-cells that enhances T-lymphocyte proliferation and activity. + termDef: + term: >- + Autologous CD19/PD-1 Bispecific CAR-T Cells + source: NCIt + cde_id: C172387 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172387" + term_id: C172387 + term_version: 20.10d + +autologous_cd19targeted_car_t_cells_cc97540: + common: + description: >- + A preparation of autologous T-lymphocytes that have been genetically modified + to express a chimeric antigen receptor (CAR) specific for the tumor-associated + antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. + Upon administration, autologous CD19-targeted CAR T cells CC-97540 specifically + target and bind to CD19-expressing tumor cells. This results in a cytotoxic + T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell + lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface + antigen overexpressed in B-cell lineage tumors. + termDef: + term: >- + Autologous CD19-targeted CAR T Cells CC-97540 + source: NCIt + cde_id: C175049 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175049" + term_id: C175049 + term_version: 20.10d + +autologous_cd19targeted_cart_cells_gc007f: + common: + description: >- + A preparation of autologous T-lymphocytes that have been genetically modified + to express a chimeric antigen receptor (CAR) consisting of a single chain variable + fragment (scFv) of anti-CD19 coupled to as of yet not fully elucidated co-stimulatory + molecules, with potential immunostimulating and antineoplastic activities. Upon + transfusion, autologous CD19-targeted CAR-T cells GC007F target and bind to + CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte + (CTL) response against CD19-expressing tumor cells, the release of cytotoxic + molecules and the induction of tumor cell lysis. CD19, cluster of differentiation + 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage + tumors. The processing platform used, FasT (F) CAR-T, shortens the manufacturing + time to produce the CAR-T cells within 24 hours. + termDef: + term: >- + Autologous CD19-targeted CAR-T Cells GC007F + source: NCIt + cde_id: C171092 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171092" + term_id: C171092 + term_version: 20.10d + +autologous_clonal_neoantigen_t_cells_atl001: + common: + description: >- + A preparation of personalized tumor-derived T-lymphocytes composed of tumor + infiltrating lymphocytes (TILs) that are reactive to clonal cancer neoantigens, + with potential immunostimulating and antineoplastic activities. The TILs are + removed from the suppressive tumor microenvironment (TME) and re-activated. + Upon reintroduction into the patient, the clonal neoantigen T (cNeT) cells recognize + and bind to tumor cells expressing the targeted neoantigen, resulting in a cytotoxic + T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells. + termDef: + term: >- + Autologous Clonal Neoantigen T Cells ATL001 + source: NCIt + cde_id: C171097 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171097" + term_id: C171097 + term_version: 20.10d + +autologous_crispredited_anticd19_car_t_cells_xyf19: + common: + description: >- + A preparation of autologous T-lymphocytes transduced with a lentiviral vector + encoding a chimeric antigen receptor (CAR) specific for the tumor-associated + antigen (TAA) CD19, and electroporated with clustered regularly interspaced + short palindromic repeats (CRISPR) guide RNA to disrupt expression of endogenous + hematopoietic progenitor kinase 1 (HPK1), with potential immunostimulating and + antineoplastic activities. Upon introduction into the patient, the autologous + CRISPR-edited anti-CD19 CAR T-cells XYF19 recognize and bind to CD19-overexpressing + tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated + killing of CD19-positive tumor cells. Disrupting the expression of HPK1 may + enhance immune response and autoimmunity. CD19 antigen is a B-cell specific + cell surface antigen expressed in all B-cell lineage malignancies. HPK1 is a + Ste20-like serine/threonine kinase that suppresses immune responses and autoimmunity. + termDef: + term: >- + Autologous CRISPR-edited Anti-CD19 CAR T Cells XYF19 + source: NCIt + cde_id: C170914 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170914" + term_id: C170914 + term_version: 20.10d + +autologous_monocytederived_lysatepulsed_dendritic_cell_vaccine_pv001dc: + common: + description: >- + A cell-based cancer vaccine composed of autologous, monocyte-derived dendritic + cells (mDCs) pulsed with tumor cell lysate containing tumor associated antigens + (TAAs), with potential immunostimulatory and antineoplastic activities. Upon + administration,the autologous tumor cell lysate-pulsed mDCs vaccine PV-001-DC + may stimulate an anti-tumoral cytotoxic T-lymphocyte (CTL) response against + tumor cells expressing the patient's tumor cell-specific TAAs, which may result + in tumor cell lysis. + termDef: + term: >- + Autologous Monocyte-derived Lysate-pulsed Dendritic Cell Vaccine PV-001-DC + source: NCIt + cde_id: C173442 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173442" + term_id: C173442 + term_version: 20.10d + +autologous_multilineage_potential_cells: + common: + description: >- + A preparation of autologous multi-lineage potential cells (AMPC) which were + induced to de-differentiate from somatic leukocytes from peripheral blood, with + potential immunomodulating and antineoplastic activities. Upon introduction + into the patient, the AMPC may help replace the abnormal cells in the body to + create healthy bone marrow in the treatment of acute myeloid leukemia (AML). + termDef: + term: >- + Autologous Multi-lineage Potential Cells + source: NCIt + cde_id: C170908 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170908" + term_id: C170908 + term_version: 20.10d + +autologous_nectin4faptargeted_cart_cells: + common: + description: >- + A preparation of autologous T-lymphocytes engineered to express a chimeric antigen + receptor (CAR) specific for the tumor-associated antigen (TAA) nectin-4 and + cell surface protein fibroblast activation protein (FAP), and additionally an + inducible expression cassette encoding transgenic interleukin (IL) 7 (IL-7) + or 12 (IL-12), with potential immunostimulating and antineoplastic activities. + Upon intratumoral administration, the autologous nectin-4/FAP-targeted CAR-T + cells target and bind to nectin-4-expressing tumor cells and FAP-expressing + cancer associated fibroblasts (CAFs). This results in a cytotoxic T-lymphocyte + (CTL) response against nectin-4-expressing tumor cells and FAP-expressing CAFs, + leading to cell lysis of these cells. Upon the binding to nectin-4 and FAP and + the activation of the CAR-T cells, cytokine IL-7 or IL-12 is also released. + This further augments the immune responses against the tumor cells, which may + include the attack of nectin-4-negative tumor cells by tumor necrosis factor + alpha (TNFa). Nectin-4, a TAA belonging to the nectin family, is overexpressed + in a variety of cancers, including breast, bladder, lung and pancreatic cancer. + FAP, a cell surface glycoprotein, is overexpressed on CAFs but minimally expressed + on normal, healthy cells. + termDef: + term: >- + Autologous Nectin-4/FAP-targeted CAR-T Cells + source: NCIt + cde_id: C172386 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172386" + term_id: C172386 + term_version: 20.10d + +autologous_nkg2d_car_tcells_cyad02: + common: + description: >- + A preparation of autologous T-lymphocytes that have been genetically modified + and transduced with a retroviral vector to co-express a chimeric antigen receptor + (CAR) encoding human natural-killer group 2, member D receptor protein (NKG2D + or KLRK1) with a short hairpin RNA (shRNA) targeting MHC class I chain-related + protein A (MICA) and MICB, with potential immunostimulating and antineoplastic + activities. Upon infusion back into the patient, autologous NKG2D CAR T-cells + CYAD-02 specifically recognize and bind to tumor cells expressing NKG2D ligands, + resulting in the lysis of NKG2D ligand-expressing tumor cells. In addition, + CYAD-02 targets, binds to and kills NKG2D ligand expressing tumor-associated + endothelial cells in the neovasculature and immunosuppressive cells, such as + regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the + tumor microenvironment (TME) that express NKG2D ligands. It also activates macrophages + within the TME. Ligands for NKG2D, such as MICA, MICB, and members of the UL16-binding + proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed + on infected cells and most cancer cell types, but are not expressed on most + normal, healthy cells. NKG2D, a dimeric, type II transmembrane protein expressed + on human natural killer (NK) and certain T-cells, in association with the natural + adaptive protein DAP10, promotes the elimination of NKG2D ligand-expressing + cells. The shRNA downregulates the expression of MICA and MICB on the CAR-T + cells, which increases in-vitro cell expansion. This may enhance their persistence + and increase anti-tumor activity. + termDef: + term: >- + Autologous NKG2D CAR T-cells CYAD-02 + source: NCIt + cde_id: C173710 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173710" + term_id: C173710 + term_version: 20.10d + +autologous_pancreatic_adenocarcinoma_lysate_and_mrnaloaded_dendritic_cell_vaccine: + common: + description: >- + A cell-based cancer vaccine composed of autologous dendritic cells (DCs) loaded + with pancreatic adenocarcinoma lysate and mRNA containing and encoding tumor + associated antigens (TAAs), with potential immunostimulatory and antineoplastic + activities. Upon administration by perinodal injection using ultrasound guidance, + the autologous pancreatic adenocarcinoma lysate and mRNA-loaded DC vaccine may + stimulate an anti-tumoral cytotoxic T-lymphocyte (CTL) response against tumor + cells expressing the patient's tumor cell-specific TAAs, which may result in + tumor cell lysis. + termDef: + term: >- + Autologous Pancreatic Adenocarcinoma Lysate and mRNA-loaded Dendritic Cell + Vaccine + source: NCIt + cde_id: C173968 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173968" + term_id: C173968 + term_version: 20.10d + +autologous_peripheral_blood_lymphocytes_from_ibrutinibtreated_chronic_lymphocytic_leukemia_patients_iov2001: + common: + description: >- + A preparation of autologous peripheral blood lymphocytes (PBLs) harvested from + chronic lymphocytic leukemia (CLL) patients previously treated with the Brutons' + tyrosine kinase (BTK) inhibitor ibrutinib with potential immunostimulating and + antineoplastic activities. Upon intravenous administration, IOV-2001 generates + an enhanced cytotoxic T-cell response against autologous leukemic B-cells in + patients who have relapsed during treatment with ibrutinib. IOV-2001 is mostly + comprised of T-cells of which the majority are of the effector memory phenotype + which augments the specificity of the immune response. + termDef: + term: >- + Autologous Peripheral Blood Lymphocytes from Ibrutinib-treated Chronic Lymphocytic + Leukemia Patients IOV-2001 + source: NCIt + cde_id: C167208 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167208" + term_id: C167208 + term_version: 20.10d + +autologous_rapamycinresistant_th1tc1_cells_rapa201: + common: + description: >- + A preparation of autologous rapamycin-resistant Th1/Tc1 cells, with potential + immunomodulating activity. Upon administration, autologous rapamycin-resistant + Th1/Tc1 cells RAPA-201 may recognize and kill tumor cells. Ex-vivo induction + of rapamycin-resistance may increase the persistence of T-cells after adoptive + transfer. + termDef: + term: >- + Autologous Rapamycin-resistant Th1/Tc1 Cells RAPA-201 + source: NCIt + cde_id: C174405 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174405" + term_id: C174405 + term_version: 20.10d + +autologous_tcrmexpressing_tcells_et140203: + common: + description: >- + A preparation of autologous T-lymphocytes that have been transduced with a lentiviral + vector to express a T-cell receptor mimetic (TCRm) construct targeting as of + yet undisclosed tumor associated antigen(s) (TAA), with potential immunomodulatory + and antineoplastic activities. Upon administration, the autologous TCRm-expressing + T-cells ET140203 specifically recognize and selectively bind to the as of yet + undisclosed TAA(s). This results in cytotoxic T-lymphocyte (CTL)-mediated killing + of tumor cells expressing the TAA(s). + termDef: + term: >- + Autologous TCRm-expressing T-cells ET140203 + source: NCIt + cde_id: C175306 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175306" + term_id: C175306 + term_version: 20.10d + +autologous_tetravalent_dendritic_cell_vaccine_midrix4lung: + common: + description: >- + A therapeutic cancer vaccine composed of autologous, dendritic cells (DCs) that + have been loaded with a proprietary selection of four antigens that covers more + than ninety percent of all non-small cell lung cancer (NSCLC) patients, with + potential immunostimulatory and antineoplastic activities. Upon administration, + autologous tetravalent dendritic cell vaccine MIDRIX4-LUNG may induce and stimulate + both T-helper and antigen-specific cytotoxic T-lymphocyte (CTL) responses, leading + to tumor cell lysis in patients with NSCLC. + termDef: + term: >- + Autologous Tetravalent Dendritic Cell Vaccine MIDRIX4-LUNG + source: NCIt + cde_id: C168775 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168775" + term_id: C168775 + term_version: 20.10d + +autologous_tumor_infiltrating_lymphocytes_ln145s1: + common: + description: >- + A proprietary preparation of autologous tumor infiltrating lymphocytes (TILs), + with potential immunomodulating and antineoplastic activities. The autologous + TILs are isolated from an autologous tumor sample and expanded ex vivo in the + presence of interleukin-2 (IL-2). Upon infusion of the autologous TILs LN-145-S1 + back into the patient, the cells specifically recognize, target and kill the + patient's tumor cells. + termDef: + term: >- + Autologous Tumor Infiltrating Lymphocytes LN-145-S1 + source: NCIt + cde_id: C173508 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173508" + term_id: C173508 + term_version: 20.10d + +autologous_universal_carexpressing_tlymphocytes_unicar02t: + common: + description: >- + A preparation of autologous T-lymphocytes that has been genetically engineered + to express a fully humanized, universal, second generation chimeric antigen + receptor (CAR) with a CD28/CD3zeta co-stimulatory domain, and a binding domain + that can recognize a peptide motive of an antigen-specific targeting module + (TM), with potential immunomodulating and antineoplastic activities. Upon administration, + autologous universal CAR-expressing T-lymphocytes UniCAR02-T remain inactivated. + Upon administration of an antigen-specific TM, the binding domain of UniCAR02-T + binds to the nuclear antigen motif of the TM, and UniCAR02-T is activated when + the antigen-binding moiety of the TM binds to the specific antigen expressed + on tumor cells. This induces selective toxicity in and causes lysis of tumor + cells expressing the specific antigen. + termDef: + term: >- + Autologous Universal CAR-expressing T-lymphocytes UniCAR02-T + source: NCIt + cde_id: C175463 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175463" + term_id: C175463 + term_version: 20.10d + +autonomic_nervous_system_nos: + common: + description: >- + The part of the nervous system of vertebrates that controls involuntary actions + of the smooth muscles and heart and glands. + termDef: + term: >- + Autonomic Nervous System + source: NCIt + cde_id: C12673 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12673" + term_id: C12673 + term_version: 20.05a + +autopsy: + common: + description: >- + A postmortem examination of the body that includes an examination of the internal + organs and structures after dissection to determine the cause of death and the + nature of pathological changes. + termDef: + term: >- + Autopsy + source: NCIt + cde_id: C25153 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25153" + term_id: C25153 + term_version: 19.12e + +avdoralimab: + common: + description: >- + A human monoclonal antibody targeting the C5a receptor (C5aR), with potential + immunomodulating activity. Upon administration, avdoralimab specifically targets, + binds to and blocks C5aR expressed on subsets of myeloid-derived suppressor + cells (MDSCs) and neutrophils. This prevents the binding of its ligand C5a to + C5aR and prevents the C5aR-mediated activation and accumulation of these cells + in the tumor microenvironment (TME), and abrogates the secretion of inflammatory + and angiogenic factors by these cells. This results in the activation of T- + and natural killer (NK) cells, the induction of anti-tumor immune responses + and inhibits tumor cell proliferation. C5a, a factor in the complement cascade, + is often overexpressed in tumors, where it attracts and activates MDSCs and + neutrophils in the TME. + termDef: + term: >- + Avdoralimab + source: NCIt + cde_id: C163020 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C163020" + term_id: C163020 + term_version: 20.10d + +aviscumine: + common: + description: >- + A recombinant protein that inactivates the ribosome with potential antineoplastic + and immunomodulating activities. Aviscumine binds to the cell surface sialyltransferase + CD75 and is internalized; intracellularly, aviscumine cleaves an adenine-specific + N-glycosidic bond on the 28S ribosomal subunit, which may result in tumor cell + apoptosis. This agent has also been shown to activate natural killer (NK) cells, + induce cytokine receptor expression, and stimulate the release of cytokines. + CD75 is expressed on mature B-cells and subsets of T-cells and erythrocytes. + termDef: + term: >- + Aviscumine + source: NCIt + cde_id: C78188 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C78188" + term_id: C78188 + term_version: 20.10d + +axalimogene_filolisbac: + common: + description: >- + A cancer vaccine containing a live-attenuated strain of the bacterium Listeria + monocytogenes (Lm) encoding human papillomavirus (HPV) type 16 E7 fused to a + non-hemolytic listeriolysin O protein with potential immunostimulatory and antineoplastic + activities. Upon vaccination with axalimogene filolisbac, Listeria expresses + the HPV 16 E7 antigen and activates the immune system to mount a cytotoxic T-lymphocyte + (CTL) response against cancer cells expressing HPV 16 E7. This may result in + tumor cell lysis. In addition, the Listeria vector itself may induce a potent + immune response. HPV 16 E7, a cell surface glycoprotein and tumor associated + antigen, is overexpressed in the majority of cervical cancer cells. + termDef: + term: >- + Axalimogene Filolisbac + source: NCIt + cde_id: C74595 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74595" + term_id: C74595 + term_version: 20.10d + +axatilimab: + common: + description: >- + A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against colony-stimulating + factor 1 receptor (CSF-1R), with potential antineoplastic activity. Upon intravenous + administration, axatilimab binds to the ligand binding domain of CSF-1R, preventing + binding and consequent activation by its natural ligands, IL-34 and colony-stimulating + factor 1 (CSF-1). Inhibition of CSF-1R activation may disrupt the activity of + tumor-associated macrophages (TAMs), which promote initiation and metastasis + of tumor cells, inhibit T-cell responses, and stimulate tumor angiogenesis and + disease progression. CSF-1R, also known as macrophage colony-stimulating factor + receptor (M-CSFR) and cluster of differentiation 115 (CD115), is a tyrosine-protein + kinase that plays an essential role in the regulation, proliferation, survival + and differentiation of tissue macrophages as well as TAMs. + termDef: + term: >- + Axatilimab + source: NCIt + cde_id: C155813 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155813" + term_id: C155813 + term_version: 20.10d + +axillary: + common: + description: >- + One of approximately 20-30 lymph nodes in chain formation that traverse the + concavity of the underarm to the clavicle. + termDef: + term: >- + Axillary Lymph Node + source: NCIt + cde_id: C12904 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12904" + term_id: C12904 + term_version: 20.10d + +axillary_tail_of_breast: + common: + description: >- + The superolateral extension of the mammary gland into the axilla that consists + of fibroadipose tissue, lymph nodes, and lymphatics. + termDef: + term: >- + Axillary Tail of the Breast + source: NCIt + cde_id: C12305 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12305" + term_id: C12305 + term_version: 20.05a + +axin1: + common: + description: >- + This gene plays a role in signal transduction and is involved in development. + termDef: + term: >- + AXIN1 Gene + source: NCIt + cde_id: C19969 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19969" + term_id: C19969 + term_version: 20.10d + +axin2: + common: + description: >- + This gene is involved in signal transduction and plays a role in development. + termDef: + term: >- + AXIN2 Gene + source: NCIt + cde_id: C20763 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20763" + term_id: C20763 + term_version: 20.10d + +axl_flt3vegfr2_inhibitor_kc1036: + common: + description: >- + An orally bioavailable inhibitor of three receptor tyrosine kinases: AXL (UFO), + FMS-like tyrosine kinase-3 (Flt3; CD135; fetal liver kinase-2; Flk2), and the + vascular endothelial growth factor receptor type 2 (VEGFR2), with potential + anti-angiogenesis and antineoplastic activities. Upon oral administration, KC1036 + targets, binds to and prevents the activation of AXL, FLT3 and VEGFR2. This + blocks AXL, FLT3 and VEGFR2-mediated signal transduction pathways, and inhibits + both AXL-, FLT3- and VEGFR2-mediated proliferation of tumor cells and the VEGFR2-mediated + proliferation, survival and migration of endothelial cells. AXL, a member of + the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed + by many tumor cell types and also expressed in a variety of immune cells including + macrophages, natural killer (NK) cells, and regulatory T-cells (Tregs). It plays + a key role in tumor cell proliferation, survival, invasion and metastasis, and + is a mediator of immunosuppression. Its expression is associated with drug resistance + and poor prognosis. FLT3, a class III tyrosine kinase receptor, is overexpressed + or mutated in most B lineage and acute myeloid leukemias. VEGFR2 is frequently + overexpressed by a variety of tumor types and tumor-associated endothelial cells. + termDef: + term: >- + AXL/ FLT3/VEGFR2 Inhibitor KC1036 + source: NCIt + cde_id: C173961 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173961" + term_id: C173961 + term_version: 20.10d + +axl_inhibitor_slc391: + common: + description: >- + An orally bioavailable and selective inhibitor of the receptor tyrosine kinase + AXL (UFO), with potential immunostimulating and antineoplastic activities. Upon + oral administration, SLC-391 targets, binds to and prevents the activation of + AXL. This blocks AXL-mediated signal transduction pathways, and inhibits both + AXL-mediated tumor cell growth, proliferation and migration and AXL-mediated + immunosuppression. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor + tyrosine kinases, is overexpressed by many tumor cell types and also expressed + in a variety of immune cells including macrophages, natural killer (NK) cells, + and regulatory T-cells (Tregs). It plays a key role in tumor cell proliferation, + survival, invasion and metastasis, and is a mediator of immunosuppression. Its + expression is associated with drug resistance and poor prognosis. + termDef: + term: >- + AXL Inhibitor SLC-391 + source: NCIt + cde_id: C173362 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173362" + term_id: C173362 + term_version: 20.10d + +axlmer_inhibitor_pf07265807: + common: + description: >- + An inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO) and Mer, with + potential antineoplastic activity. Upon administration, Axl/Mer inhibitor PF-07265807 + specifically targets and binds to both Axl and Mer, and prevents their activity. + This blocks Axl- and Mer-mediated signal transduction pathways, and inhibits + proliferation and migration of Axl- and Mer-overexpressing tumor cells. Axl + and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed + by many tumor cell types. They play key roles in tumor cell proliferation, survival, + invasion, angiogenesis and metastasis, and their expression is associated with + drug resistance and poor prognosis. + termDef: + term: >- + Axl/Mer Inhibitor PF-07265807 + source: NCIt + cde_id: C175543 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175543" + term_id: C175543 + term_version: 20.10d + +azerbaijan: + common: + description: >- + A country in southwestern Asia, bordering the Caspian Sea, between Iran and + Russia. + termDef: + term: >- + Azerbaijan + source: NCIt + cde_id: C16316 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16316" + term_id: C16316 + term_version: 19.12e + +azintuxizumab_vedotin: + common: + description: >- + An antibody-drug conjugate (ADC) composed of an antibody targeting CS1 (SLAMF7/CD319) + that is conjugated to the microtubule-disrupting cytotoxic agent monomethyl + auristatin E (MMAE), via a cathepsin-cleavable linker, with potential antineoplastic + activity. Upon administration, the antibody moiety of azintuxizumab vedotin + binds to CS1-expressing tumor cells and is internalized, thereby delivering + MMAE intracellularly. Upon cleavage, MMAE binds to tubulin and inhibits its + polymerization, resulting in G2/M checkpoint arrest and apoptosis in CS1-expressing + tumor cells. CS1 is a cell surface glycoprotein belonging to the CD2 subset + of the immunoglobulin superfamily (IgSF) and is expressed with high levels and + prevalence on multiple myeloma (MM) cells. + termDef: + term: >- + Azintuxizumab Vedotin + source: NCIt + cde_id: C122816 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122816" + term_id: C122816 + term_version: 20.10d + +b: + common: + description: >- + Child-Pugh score indicating one-year survival of 80% in patients with chronic + liver disease and cirrhosis. This score is determined by the study of the following + five factors: bilirubin, albumin, international normalized ratio, presence and + degree of ascites, and presence and degree of encephalopathy. + termDef: + term: >- + Child-Pugh Class B + source: NCIt + cde_id: C113692 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113692" + term_id: C113692 + term_version: 20.05a + +b_lymphoblastic_leukemialymphoma_nos: + common: + description: >- + The term refers to precursor lymphoid neoplasms which are composed of B-lymphoblasts + and characterized by the absence of recurrent genetic abnormalities. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified + source: NCIt + cde_id: C80326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80326" + term_id: C80326 + term_version: 20.05a + +b_lymphoblastic_leukemialymphoma_with_hyperdiploidy: + common: + description: >- + A precursor lymphoid neoplasm composed of B-lymphoblasts which contain more + than 50 and usually less than 66 chromosomes. It has a favorable clinical outcome. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with Hyperdiploidy + source: NCIt + cde_id: C80335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80335" + term_id: C80335 + term_version: 20.05a + +b_lymphoblastic_leukemialymphoma_with_hypodiploidy_hypodiploid_all: + common: + description: >- + A precursor lymphoid neoplasm composed of B-lymphoblasts which contain less + than 46 chromosomes. It has an unfavorable clinical outcome. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with Hypodiploidy + source: NCIt + cde_id: C80338 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80338" + term_id: C80338 + term_version: 20.05a + +b_lymphoblastic_leukemialymphoma_with_t119q23p133_e2apbx1_tcf3pbx1: + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the E2A gene on chromosome 19 and the PBX1 gene on chromosome + 1. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) + source: NCIt + cde_id: C80341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80341" + term_id: C80341 + term_version: 20.05a + +b_lymphoblastic_leukemialymphoma_with_t1221p13q22_telaml1_etv6runx1: + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the TEL gene on chromosome 12 and the AML1 gene on chromosome + 21, (p13.2;q22.1). It results in the production of the TEL-AML1 (ETV6-RUNX1) + fusion protein. It has a favorable clinical outcome. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1 + source: NCIt + cde_id: C80334 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80334" + term_id: C80334 + term_version: 20.05a + +b_lymphoblastic_leukemialymphoma_with_t514q31q32_il3igh: + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the IL3 gene on chromosome 5 and the IGH locus on chromosome + 14, (q31.1;q32.3). It results in eosinophilia. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH + source: NCIt + cde_id: C80340 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80340" + term_id: C80340 + term_version: 20.05a + +b_lymphoblastic_leukemialymphoma_with_t922q34q112_bcrabl1: + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome + 9. It results in the production of the p190 kd or p210 kd fusion protein. It + has an unfavorable clinical outcome. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1 + source: NCIt + cde_id: C80331 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80331" + term_id: C80331 + term_version: 20.05a + +b_lymphoblastic_leukemialymphoma_with_tv11q23_mll_rearranged: + common: + description: >- + A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries + a translocation between the KMT2A gene at 11q23.3 and another gene partner resulting + in the production of a KMT2A related fusion protein. + termDef: + term: >- + B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged + source: NCIt + cde_id: C80332 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80332" + term_id: C80332 + term_version: 20.05a + +b2m: + common: + description: >- + This gene plays a role in immune responses. + termDef: + term: >- + B2M Gene + source: NCIt + cde_id: C62660 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62660" + term_id: C62660 + term_version: 20.10d + +b7: + common: + description: >- + A total score of 7 for hepatic function, corresponding to class B in the Child-Pugh + classification. + termDef: + term: >- + Child-Pugh Class B7 + source: NCIt + cde_id: C146792 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146792" + term_id: C146792 + term_version: 20.05a + +b8: + common: + description: >- + A total score of 8 for hepatic function, corresponding to class B in the Child-Pugh + classification. + termDef: + term: >- + Child-Pugh Class B8 + source: NCIt + cde_id: C146793 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146793" + term_id: C146793 + term_version: 20.05a + +b9: + common: + description: >- + A total score of 9 for hepatic function, corresponding to class B in the Child-Pugh + classification. + termDef: + term: >- + Child-Pugh Class B9 + source: NCIt + cde_id: C146794 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146794" + term_id: C146794 + term_version: 20.05a + +bahamas: + common: + description: >- + A chain of islands in the North Atlantic Ocean, southeast of Florida and north + of Cuba. + termDef: + term: >- + Bahamas + source: NCIt + cde_id: C16321 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16321" + term_id: C16321 + term_version: 19.12e + +bahrain: + common: + description: >- + An archipelago in the Persian Gulf, on the east coast of Saudi Arabia. + termDef: + term: >- + Bahrain + source: NCIt + cde_id: C16322 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16322" + term_id: C16322 + term_version: 19.12e + +ball: + common: + description: >- + The most frequent type of acute lymphoblastic leukemia. Approximately 75% of + cases occur in children under six years of age. This is a good prognosis leukemia. In + the pediatric age group the complete remission rate is approximately 95% and + the disease free survival rate is 70%. Approximately 80% of children appear + to be cured. In the adult age group the complete remission rate is 60-85%. (WHO, + 2001) + termDef: + term: >- + B Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C8644 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8644" + term_id: C8644 + term_version: 20.05a + +balloon_cell_melanoma: + common: + description: >- + A rare variant of melanoma with a vertical growth phase. It presents as a nodular + or polypoid skin lesion. It is characterized by the presence of nodules which + contain large melanoma cells with clear, foamy or finely vacuolated cytoplasm. + The prognosis is similar to that of other melanomas matched for depth of invasion. + termDef: + term: >- + Balloon Cell Melanoma + source: NCIt + cde_id: C4227 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4227" + term_id: C4227 + term_version: 20.05a + +balloon_cell_nevus: + common: + description: >- + An uncommon variant of melanocytic nevus. It presents as a small pigmented skin + lesion. It is characterized by the presence of large melanocytes with clear, + foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised. + termDef: + term: >- + Balloon Cell Nevus + source: NCIt + cde_id: C4226 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4226" + term_id: C4226 + term_version: 20.05a + +balstilimab: + common: + description: >- + A monoclonal antibody directed against the negative immunoregulatory human cell + surface receptor programmed cell death 1 (PD-1, PCD-1; PDCD1) protein, with + potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, + balstilimab binds to PD-1, and thereby blocks its binding to the PD-1 ligand + programmed cell death-1 ligand 1 (PD-L1), and prevents the activation of its + downstream signaling pathways. This may restore immune function through the + activation of cytotoxic T-cells. PD-1, a transmembrane protein in the immunoglobulin + superfamily expressed on activated T-cells, negatively regulates T-cell activation + and effector function when activated by its ligand; it plays an important role + in tumor evasion from host immunity. + termDef: + term: >- + Balstilimab + source: NCIt + cde_id: C136465 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C136465" + term_id: C136465 + term_version: 20.10d + +balt_lymphoma: + common: + description: >- + An extranodal marginal zone lymphoma that arises from the lung. It is characterized + by the neoplastic proliferation of small B-lymphocytes, monocytoid cells and + cells with plasma cell differentiation in the marginal zones of reactive lymphoid + follicles. The neoplastic cells infiltrate the interfollicular areas and the + bronchial epithelium forming lymphoepithelial lesions. The neoplasm is usually + discovered as a mass in a chest x-ray in asymptomatic patients. When symptoms + occur, they include cough, dyspnea, hemoptysis, and chest pain. If the lung + lesions are resectable, surgery can result in prolonged remission. + termDef: + term: >- + Bronchial Mucosa-Associated Lymphoid Tissue Lymphoma + source: NCIt + cde_id: C5264 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5264" + term_id: C5264 + term_version: 20.05a + +bangladesh: + common: + description: >- + A country in southern Asia, bordering the Bay of Bengal, between Burma and India. + termDef: + term: >- + Bangladesh + source: NCIt + cde_id: C16323 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16323" + term_id: C16323 + term_version: 19.12e + +bap1: + common: + description: >- + This gene is involved in cellular growth regulation and is purported to have + tumor suppression activity. + termDef: + term: >- + BAP1 Gene + source: NCIt + cde_id: C20766 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20766" + term_id: C20766 + term_version: 20.10d + +barbados: + common: + description: >- + An island between the Caribbean Sea and the North Atlantic Ocean, east of Saint + Vincent and the Grenadines. + termDef: + term: >- + Barbados + source: NCIt + cde_id: C16324 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16324" + term_id: C16324 + term_version: 19.12e + +bard1: + common: + description: >- + This gene plays a role in cellular response and is susceptible to oncogenic + mutations in breast and ovarian cancers. + termDef: + term: >- + BARD1 Gene + source: NCIt + cde_id: C20715 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20715" + term_id: C20715 + term_version: 20.10d + +basal_cell_adenocarcinoma: + common: + description: >- + A rare adenocarcinoma of the major and minor salivary glands, originating from + basaloid, myoepithelial and ductal cells. While morphologically resembling + basal cell carcinomas, it is a distinct entity. The tumor is not encapsulated, + may invade locally, and less frequently may metastasize. It usually occurs + in older patients. + termDef: + term: >- + Salivary Gland Basal Cell Adenocarcinoma + source: NCIt + cde_id: C3678 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3678" + term_id: C3678 + term_version: 20.05a + +basal_cell_adenoma: + common: + description: >- + A benign epithelial neoplasm with a uniform, monomorphic appearance that is + dominated by basal cells forming trabecular structures. It is rare, and occurs + mostly on the parotid gland. The average age of patients has been reported to + be 58 years. Swelling is the most constant clinical finding. + termDef: + term: >- + Salivary Gland Basal Cell Adenoma + source: NCIt + cde_id: C5950 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5950" + term_id: C5950 + term_version: 20.05a + +basal_cell_cancer: + common: + description: >- + The most frequently seen skin cancer. It arises from basal cells of the epidermis + and pilosebaceous units. Clinically it is divided into the following types: + nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing + or morphea-like. More than 95% of these carcinomas occur in patients over 40. + They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately + 85% are found on the head and neck and the remaining 15% on the trunk and extremities. + Basal cell carcinoma usually grows in a slow and indolent fashion. However, + if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and + bone. Distant metastases are rare. Excision, curettage and irradiation cure + most basal cell carcinomas. + termDef: + term: >- + Skin Basal Cell Carcinoma + source: NCIt + cde_id: C2921 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2921" + term_id: C2921 + term_version: 19.12e + +basal_cell_carcinoma_desmoplastic_type: + common: + description: >- + A variant of basal cell carcinoma presenting as a pale, indurated plaque, usually + in the upper trunk or face. Morphologically, it is characterized by the presence + of strands, cords, and columns of basaloid cells infiltrating the dermis. Perineural + invasion may be present and the basaloid cell infiltrate may extend into deeper + tissues. + termDef: + term: >- + Skin Infiltrating Basal Cell Carcinoma + source: NCIt + cde_id: C27539 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27539" + term_id: C27539 + term_version: 20.05a + +basal_cell_carcinoma_fibroepithelial: + common: + description: >- + A variant of basal cell carcinoma presenting as an elevated or erythematous + nodular lesion usually in the back. Morphologically, it is characterized by + the presence of cords of basaloid cells extending from the epidermis into the + dermis, creating a fenestrating pattern. It follows an indolent course. + termDef: + term: >- + Skin Fibroepithelial Basal Cell Carcinoma + source: NCIt + cde_id: C4109 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4109" + term_id: C4109 + term_version: 20.05a + +basal_cell_carcinoma_micronodular: + common: + description: >- + A basal cell carcinoma of the skin characterized by the presence of small nodules + that permeate the dermis. It presents as an elevated or flat infiltrating tumor, + usually in the back. + termDef: + term: >- + Skin Micronodular Basal Cell Carcinoma + source: NCIt + cde_id: C27541 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27541" + term_id: C27541 + term_version: 20.05a + +basal_cell_carcinoma_morpheic: + common: + description: >- + A variant of basal cell carcinoma presenting as a pale, indurated plaque, usually + in the upper trunk or face. Morphologically, it is characterized by the presence + of strands, cords, and columns of basaloid cells infiltrating the dermis. Perineural + invasion may be present and the basaloid cell infiltrate may extend into deeper + tissues. + termDef: + term: >- + Skin Infiltrating Basal Cell Carcinoma + source: NCIt + cde_id: C27539 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27539" + term_id: C27539 + term_version: 20.05a + +basal_cell_carcinoma_nodular: + common: + description: >- + A basal cell carcinoma of the skin that often appears as elevated nodules which + may become ulcerated. + termDef: + term: >- + Skin Nodular Basal Cell Carcinoma + source: NCIt + cde_id: C62282 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62282" + term_id: C62282 + term_version: 20.05a + +basal_cell_carcinoma_nos: + common: + description: >- + The most frequently seen skin cancer. It arises from basal cells of the epidermis + and pilosebaceous units. Clinically it is divided into the following types: + nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing + or morphea-like. More than 95% of these carcinomas occur in patients over 40. + They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately + 85% are found on the head and neck and the remaining 15% on the trunk and extremities. + Basal cell carcinoma usually grows in a slow and indolent fashion. However, + if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and + bone. Distant metastases are rare. Excision, curettage and irradiation cure + most basal cell carcinomas. + termDef: + term: >- + Skin Basal Cell Carcinoma + source: NCIt + cde_id: C2921 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2921" + term_id: C2921 + term_version: 20.05a + +basal_cell_epithelioma: + common: + description: >- + The most frequently seen skin cancer. It arises from basal cells of the epidermis + and pilosebaceous units. Clinically it is divided into the following types: + nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing + or morphea-like. More than 95% of these carcinomas occur in patients over 40. + They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately + 85% are found on the head and neck and the remaining 15% on the trunk and extremities. + Basal cell carcinoma usually grows in a slow and indolent fashion. However, + if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and + bone. Distant metastases are rare. Excision, curettage and irradiation cure + most basal cell carcinomas. + termDef: + term: >- + Skin Basal Cell Carcinoma + source: NCIt + cde_id: C2921 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2921" + term_id: C2921 + term_version: 20.05a + +basal_cell_tumor: + common: + description: >- + A neoplastic proliferation of basal cells in the epidermis (part of the skin) + or other anatomic sites (most frequently the salivary glands). The basal cell + neoplastic proliferation in the epidermis results in basal cell carcinomas. The + basal cell neoplastic proliferation in the salivary glands can be benign, resulting + in basal cell adenomas or malignant, resulting in basal cell adenocarcinomas. + termDef: + term: >- + Basal Cell Neoplasm + source: NCIt + cde_id: C3784 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3784" + term_id: C3784 + term_version: 20.05a + +basaloid_carcinoma: + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of neoplastic + cells with hyperchromatic nuclei, small amount of cytoplasm, and peripheral + nuclear palisading. + termDef: + term: >- + Basaloid Carcinoma + source: NCIt + cde_id: C4121 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4121" + term_id: C4121 + term_version: 20.05a + +basaloid_squamous_cell_carcinoma: + common: + description: >- + A squamous cell carcinoma characterized by the presence of cells with hyperchromatic + nuclei, scant amount of cytoplasm, and peripheral nuclear palisading. + termDef: + term: >- + Basaloid Squamous Cell Carcinoma + source: NCIt + cde_id: C54244 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54244" + term_id: C54244 + term_version: 20.05a + +base_of_tongue_nos: + common: + description: >- + The posterior one third of the tongue behind the terminal sulcus that forms + the anterior aspect of the oro-pharynx responsible for swallowing and modification + of the voice in speech. + termDef: + term: >- + Base of the Tongue + source: NCIt + cde_id: C12228 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12228" + term_id: C12228 + term_version: 20.05a + +basophil: + common: + description: >- + The determination of the absolute number of basophils in a blood sample. + termDef: + term: >- + Total Basophil Count + source: NCIt + cde_id: C64470 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64470" + term_id: C64470 + term_version: 20.10d + +basophil_adenocarcinoma: + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with basic dyes. + termDef: + term: >- + Basophilic Adenocarcinoma + source: NCIt + cde_id: C4150 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4150" + term_id: C4150 + term_version: 20.05a + +basophil_adenoma: + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells stain positive with basic dyes. + termDef: + term: >- + Pituitary Gland Basophil Adenoma + source: NCIt + cde_id: C2856 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2856" + term_id: C2856 + term_version: 20.05a + +basophil_carcinoma: + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with basic dyes. + termDef: + term: >- + Basophilic Adenocarcinoma + source: NCIt + cde_id: C4150 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4150" + term_id: C4150 + term_version: 20.05a + +basosquamous_carcinoma: + common: + description: >- + A basal cell carcinoma which displays squamous differentiation. The neoplastic + cells have more abundant cytoplasm with more marked keratinization than typical + basal cell carcinomas. It usually has a more aggressive clinical course compared + to typical basal cell carcinoma, and it may produce regional or widespread metastases. + termDef: + term: >- + Skin Basosquamous Cell Carcinoma + source: NCIt + cde_id: C2922 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2922" + term_id: C2922 + term_version: 20.05a + +bazlitoran: + common: + description: >- + An oligonucleotide targeted to the mRNA of MYD88 L265P, a mutant form of the + linker protein MYD88, with potential antitumor activity. Bazlitoran binds to + and inhibits the translation of mutated MYD88 L265P mRNA. This prevents overactivation + of signaling pathways mediated by toll-like receptors (TLRs) 7, 8, and 9, nuclear + factor-kappa B (NF-kB) activity, Janus-associated kinases-signal transducer + and activator of transcription (JAK-STAT) signaling and the production of various + cytokines. Together, this leads to an induction of apoptosis and an inhibition + of tumor cell proliferation in MYD88 L265P-expressing tumor cells. MYD88, a + key adaptor protein in the TLR signaling pathway, is mutated in a variety of + B-cell lymphomas, including Waldenstrom's macroglobulinemia (WM) and activated + B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL). + termDef: + term: >- + Bazlitoran + source: NCIt + cde_id: C114975 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C114975" + term_id: C114975 + term_version: 20.10d + +bcell_genotyping: + common: + description: >- + The determination of the genomic DNA sequences in a subject's B-cells. + termDef: + term: >- + B-Cell Genotyping Assay + source: NCIt + cde_id: C171142 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171142" + term_id: C171142 + term_version: 20.10d + +bcell_lymphocytic_leukemiasmall_lymphocytic_lymphoma: + common: + description: >- + The most common type of chronic lymphoid leukemia. It comprises 90% of chronic + lymphoid leukemias in the United States. Morphologically, the neoplastic cells + are small, round B-lymphocytes. This type of leukemia is not considered to + be curable with available therapy. (WHO, 2001) + termDef: + term: >- + Chronic Lymphocytic Leukemia + source: NCIt + cde_id: C3163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3163" + term_id: C3163 + term_version: 20.05a + +bcell_lymphoma_unclassifiable_with_features_intermediate_between_diffuse_large_bcell_lymphoma_and_burkitt_lymphoma: + common: + description: >- + A high grade B-cell lymphoma with blastoid features or features between diffuse + large B-cell lymphoma and Burkitt lymphoma which lacks MYC, BCL2, and BCL6 rearrangements. + termDef: + term: >- + High Grade B-Cell Lymphoma, Not Otherwise Specified + source: NCIt + cde_id: C80291 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80291" + term_id: C80291 + term_version: 20.05a + +bcell_lymphoma_unclassifiable_with_features_intermediate_between_diffuse_large_bcell_lymphoma_and_classical_hodgkin_lymphoma: + common: + description: >- + A group of lymphomas displaying molecular, morphologic, immunophenotypic, and + clinical overlap between classic Hodgkin lymphoma and diffuse large B-cell lymphoma. This + term particularly applies to mediastinal lymphomas with overlapping features + of mediastinal (thymic) large B-cell lymphoma and classic Hodgkin lymphoma. + termDef: + term: >- + B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse + Large B-Cell Lymphoma and Classic Hodgkin Lymphoma + source: NCIt + cde_id: C37869 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37869" + term_id: C37869 + term_version: 20.05a + +bcl10: + common: + description: >- + This gene is involved in the promotion of apoptosis. + termDef: + term: >- + BCL10 Gene + source: NCIt + cde_id: C24259 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24259" + term_id: C24259 + term_version: 20.10d + +bcl11a: + common: + description: >- + This gene is involved in both the modulation of cell shape and lymphopoiesis. + termDef: + term: >- + BCL11A Gene + source: NCIt + cde_id: C97394 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97394" + term_id: C97394 + term_version: 20.10d + +bcl11b: + common: + description: >- + This gene may play a role in tumor suppression, signaling and T cell development. + termDef: + term: >- + BCL11B Gene + source: NCIt + cde_id: C91855 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C91855" + term_id: C91855 + term_version: 20.10d + +bcl2: + common: + description: >- + This gene is involved in apoptotic regulation. Overexpression of this gene promotes + the pathogenesis of B-Cell lymphomas, due to anti-apoptotic activity. + termDef: + term: >- + BCL2 Gene + source: NCIt + cde_id: C17963 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17963" + term_id: C17963 + term_version: 20.10d + +bcl2_inhibitor_bgb11417: + common: + description: >- + An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma + 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon + oral administration, Bcl-2 inhibitor BGB-11417 specifically binds to and inhibits + the activity of the pro-survival protein Bcl-2. This restores apoptotic processes + and inhibits cell proliferation in Bcl-2-overexpressing tumor cells. Bcl-2, + a protein that belongs to the Bcl-2 family, is overexpressed in various tumor + cell types and plays an important role in the negative regulation of apoptosis. + Its tumor expression is associated with increased drug resistance and cancer + cell survival. + termDef: + term: >- + Bcl-2 Inhibitor BGB-11417 + source: NCIt + cde_id: C175489 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175489" + term_id: C175489 + term_version: 20.10d + +bcl2_inhibitor_lp108: + common: + description: >- + An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma + 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon + oral administration, Bcl-2 inhibitor LP-108 targets, binds to and inhibits the + activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is + overexpressed in many cancers and plays an important role in the negative regulation + of apoptosis; its expression is associated with increased drug resistance and + tumor cell survival. + termDef: + term: >- + Bcl-2 Inhibitor LP-108 + source: NCIt + cde_id: C173536 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173536" + term_id: C173536 + term_version: 20.10d + +bcl2l12: + common: + description: >- + This gene is involved in the regulation of apoptosis. + termDef: + term: >- + BCL2L12 Gene + source: NCIt + cde_id: C114743 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C114743" + term_id: C114743 + term_version: 20.10d + +bcl3: + common: + description: >- + This gene is involved in transcriptional co-activation and signal transduction. + termDef: + term: >- + BCL3 Gene + source: NCIt + cde_id: C18360 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18360" + term_id: C18360 + term_version: 20.10d + +bcl6: + common: + description: >- + This gene is involved in transcriptional repression and plays a role in the + modulation of B-cell responses. + termDef: + term: >- + B-Cell Lymphoma 6 Protein + source: NCIt + cde_id: C24260 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24260" + term_id: C24260 + term_version: 20.10d + +bcl7a: + common: + description: >- + This gene may play a role in signal transduction. + termDef: + term: >- + BCL7A Gene + source: NCIt + cde_id: C24261 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24261" + term_id: C24261 + term_version: 20.10d + +bcl9: + common: + description: >- + This gene plays a role in signal transduction and is involved in development. + termDef: + term: >- + BCL9 Gene + source: NCIt + cde_id: C24262 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24262" + term_id: C24262 + term_version: 20.10d + +bcl9l: + common: + description: >- + This gene plays a role in the coactivation of gene transcription. + termDef: + term: >- + BCL9L Gene + source: NCIt + cde_id: C132328 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132328" + term_id: C132328 + term_version: 20.10d + +bclaf1: + common: + description: >- + Human BCLAF1 wild-type allele is located within 6q22-q23 and is approximately + 33 kb in length. This allele, which encodes Bcl-2-associated transcription factor + 1 protein, plays a role in both apoptosis promotion and the repression of transcription. + termDef: + term: >- + BCLAF1 Gene + source: NCIt + cde_id: C115994 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C115994" + term_id: C115994 + term_version: 20.10d + +bcmacd19_compound_car_t_cells: + common: + description: >- + A preparation of T-lymphocytes transduced with a lentiviral vector expressing + a compound chimeric antigen receptor (cCAR) containing two distinct units of + CARs, one specific for the tumor-associated antigen (TAA) B-cell maturation + antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) + and one specific for the TAA CD19, with potential immunomodulating and antineoplastic + activities. Upon administration, the BCMA-CD19 cCAR T cells specifically and + simultaneously target and bind to tumor cells expressing BCMA and/or CD19. This + induces selective toxicity in tumor cells that express BCMA and/or CD19. BCMA, + a tumor-specific antigen and a receptor for both a proliferation-inducing ligand + (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis + factor receptor superfamily (TNFRSF) and plays a key role in the survival of + B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and + is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell surface + antigen overexpressed in B-cell lineage malignancies. Targeting two different + antigens may improve coverage and protect against antigen escape and relapse + as it is less likely for tumor cells to lose both antigens. + termDef: + term: >- + BCMA-CD19 Compound CAR T Cells + source: NCIt + cde_id: C174412 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174412" + term_id: C174412 + term_version: 20.10d + +bcmacd3e_trispecific_tcell_activating_construct_hpn217: + common: + description: >- + A recombinant antibody derivative composed of tri-specific T-cell activating + construct (TriTAC) directed against the human tumor-associated antigen (TAA) + B-cell maturation antigen (BCMA; TNFRSF17), the epsilon domain of CD3 antigen + (CD3e) found on T-lymphocytes, and albumin, with potential immunostimulating + and antineoplastic activities. Upon administration, BCMA/CD3e TriTAC HPN217 + targets and binds to BCMA on tumor cells and CD3e on cytotoxic T-lymphocytes + (CTLs), thereby bringing BCMA-expressing tumor cells and CTLs together, which + results in the CTL-mediated cell death of BCMA-expressing tumor cells. The albumin-binding + domain targets and binds to serum albumin, thereby extending the serum half-life + of HPN217. BCMA, a member of the tumor necrosis factor receptor superfamily + (TNFRSF), is overexpressed on malignant plasma cells and plays a key role in + plasma cell survival. + termDef: + term: >- + BCMA/CD3e Tri-specific T-cell Activating Construct HPN217 + source: NCIt + cde_id: C171631 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171631" + term_id: C171631 + term_version: 20.10d + +bcor: + common: + description: >- + This gene plays a role in the repression of gene transcription. + termDef: + term: >- + BCOR Gene + source: NCIt + cde_id: C101091 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101091" + term_id: C101091 + term_version: 20.10d + +bcorl1: + common: + description: >- + This gene plays a role in the inhibition of gene expression. + termDef: + term: >- + BCORL1 Gene + source: NCIt + cde_id: C131268 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131268" + term_id: C131268 + term_version: 20.10d + +bcr: + common: + description: >- + This gene plays a role in signal transduction. + termDef: + term: >- + BCR Gene + source: NCIt + cde_id: C18455 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18455" + term_id: C18455 + term_version: 20.10d + +bednar_tumor: + common: + description: >- + A morphologic variant of dermatofibrosarcoma protuberans characterized by the + presence of melanin-pigmented dendritic cells. + termDef: + term: >- + Pigmented Dermatofibrosarcoma Protuberans + source: NCIt + cde_id: C9430 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9430" + term_id: C9430 + term_version: 20.05a + +belantamab_mafodotin: + common: + description: >- + An antibody-drug conjugate (ADC) consisting of belantamab, an afucosylated, + humanized monoclonal antibody, directed against the B-cell maturation antigen + (BCMA), conjugated to mafodotin, an auristatin analogue and microtubule inhibitor + monomethyl auristatin phenylalanine (MMAF), with potential antineoplastic activity. + Upon administration of belantamab mafodotin, the anti-BCMA antibody moiety selectively + binds to BCMA on tumor cell surfaces. Upon internalization, the MMAF moiety + binds to tubulin and inhibits its polymerization, which results in G2/M phase + arrest and induces tumor cell apoptosis. In addition, belantamab mafodotin induces + antibody-dependent cellular cytotoxicity (ADCC). Altogether, this results in + the inhibition of cellular proliferation in tumor cells that overexpress BCMA. + BCMA, a receptor for a proliferation-inducing ligand and B-cell activating factor, + is a member of the tumor necrosis factor (TNF) receptor superfamily and plays + a key role in plasma cell survival; it is found on the surfaces of plasma cells + and overexpressed on malignant plasma cells. Afucosylation of the antibody moiety + increases ADCC. + termDef: + term: >- + Belantamab Mafodotin + source: NCIt + cde_id: C114299 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C114299" + term_id: C114299 + term_version: 20.10d + +belapectin: + common: + description: >- + A carbohydrate-based galectin inhibitor, with potential antineoplastic activity. + Belapectin binds to the carbohydrate-binding domain of galectins, especially + galectin-3, and may result in an induction of apoptosis mediated through activation + of both mitochondria and caspases. This may reduce tumor growth in galectin-overexpressing + tumor cells. Galectins, often overexpressed on tumor cells, play a key role + in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune + responses. + termDef: + term: >- + Belapectin + source: NCIt + cde_id: C115111 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C115111" + term_id: C115111 + term_version: 20.10d + +belarus: + common: + description: >- + A country in eastern Europe, east of Poland and north of Ukraine. + termDef: + term: >- + Belarus + source: NCIt + cde_id: C16372 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16372" + term_id: C16372 + term_version: 19.12e + +belgium: + common: + description: >- + A country in western Europe, bordering the North Sea, between France and the + Netherlands. + termDef: + term: >- + Belgium + source: NCIt + cde_id: C16329 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16329" + term_id: C16329 + term_version: 19.12e + +belize: + common: + description: >- + A country in central America, bordering the Caribbean Sea, between Guatemala + and Mexico. + termDef: + term: >- + Belize + source: NCIt + cde_id: C16331 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16331" + term_id: C16331 + term_version: 19.12e + +bellini_duct_carcinoma: + common: + description: >- + Also known as collecting duct carcinoma, this is a rare type of renal carcinoma. + It arises from the collecting ducts of the renal medulla, and most authors suggest + that this is an aggressive tumor. + termDef: + term: >- + Collecting Duct Carcinoma + source: NCIt + cde_id: C6194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6194" + term_id: C6194 + term_version: 20.05a + +belvarafenib: + common: + description: >- + An orally available inhibitor of members of the Raf family of serine/threonine + protein kinases, with potential antineoplastic activity. Upon administration, + belvarafenib binds to and inhibits the B-Raf mutant V600E and C-Raf. This inhibits + B-Raf V600E- and C-Raf-mediated signal transduction pathways, thereby inhibiting + tumor cell growth of susceptible tumor cells. In addition, belvarafenib may + also inhibit mutated Ras proteins. Raf protein kinases play a key role in the + Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related + kinase (ERK) signaling pathway, which is often dysregulated in human cancers + and plays a key role in tumor cell proliferation and survival. The Raf mutation + B-Raf V600E, where the valine at residue 600 is substituted for glutamic acid, + is frequently overexpressed in a variety of human tumors and results in the + constitutive activation of the Raf/MEK/ERK signaling pathway. + termDef: + term: >- + Belvarafenib + source: NCIt + cde_id: C121646 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121646" + term_id: C121646 + term_version: 20.10d + +belzutifan: + common: + description: >- + An orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha + (HIF-2a), with potential antineoplastic activity. Upon oral administration, + belzutifan binds to and blocks the function of HIF-2alpha, thereby preventing + HIF-2alpha heterodimerization and its subsequent binding to DNA. This results + in decreased transcription and expression of HIF-2alpha downstream target genes, + many of which regulate hypoxic signaling. This inhibits cell growth and survival + of HIF-2alpha-expressing tumor cells. HIF-2alpha, the alpha subunit for the + heterodimeric transcription factor HIF-2, is overexpressed in many cancers and + promotes tumorigenesis. + termDef: + term: >- + Belzutifan + source: NCIt + cde_id: C135627 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C135627" + term_id: C135627 + term_version: 20.10d + +benign: + common: + description: >- + A genetic variant that is known to not contribute to the development of a disease. + termDef: + term: >- + Variant Benign + source: NCIt + cde_id: C168802 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168802" + term_id: C168802 + term_version: 20.10d + +benign_cystic_nephroma: + common: + description: >- + A localized, well-circumscribed multilocular tumor lined by hobnail epithelium. + It was previously classified along with pediatric cystic nephroma, as a separate + entity from mixed epithelial and stromal tumors. Now it is classified within + the spectrum of the mixed epithelial and stromal tumor family. Most of these + tumors are benign. (WHO 2016). + termDef: + term: >- + Adult Cystic Nephroma + source: NCIt + cde_id: C7504 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7504" + term_id: C7504 + term_version: 20.05a + +benign_fibrous_histiocytoma: + common: + description: >- + A benign neoplasm composed of fibroblastic spindle cells in a whorled storiform + pattern. It is characterized by the presence of foam cells, inflammatory cells, + hemosiderin deposition and stromal hemorrhage. + termDef: + term: >- + Benign Fibrous Histiocytoma + source: NCIt + cde_id: C3739 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3739" + term_id: C3739 + term_version: 20.05a + +benin: + common: + description: >- + A country in western Africa, bordering the North Atlantic Ocean, between Nigeria + and Togo. + termDef: + term: >- + Benin + source: NCIt + cde_id: C16333 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16333" + term_id: C16333 + term_version: 19.12e + +bermuda: + common: + description: >- + A group of islands in the North Atlantic Ocean, east of South Carolina. + termDef: + term: >- + Bermuda + source: NCIt + cde_id: C16334 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16334" + term_id: C16334 + term_version: 19.12e + +bersanlimab: + common: + description: >- + A fully human IgG1 monoclonal antibody directed against intercellular adhesion + molecule-1 (ICAM-1 or CD54), with potential antineoplastic activity. Bersanlimab + selectively binds to the adhesion protein ICAM-1, which may result in antibody-dependent + cellular cytotoxicity (ADCC), hyper-cross-linking-induced apoptosis, and a decrease + in cellular proliferation of ICAM-1-expressing tumor cells. ICAM-1, normally + expressed on leukocytes and endothelial cells, may be overexpressed in a variety + of cancers. + termDef: + term: >- + Bersanlimab + source: NCIt + cde_id: C88327 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C88327" + term_id: C88327 + term_version: 20.10d + +berzosertib: + common: + description: >- + An inhibitor of ataxia telangiectasia and rad3-related (ATR) kinase, a DNA damage + response kinase, with potential antineoplastic activity. Upon administration, + berzosertib selectively binds to and inhibits ATR kinase activity and prevents + ATR-mediated signaling in the ATR-checkpoint kinase 1 (Chk1) signaling pathway. + This prevents DNA damage checkpoint activation, disrupts DNA damage repair, + and induces tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated + in a variety of cancer cell types, plays a key role in DNA repair, cell cycle + progression, and survival; it is activated by DNA damage caused during DNA replication-associated + stress. + termDef: + term: >- + Berzosertib + source: NCIt + cde_id: C116355 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116355" + term_id: C116355 + term_version: 20.10d + +beta_2_microglobulin: + common: + description: >- + The determination of the amount of beta-2 microglobulin present in a sample. + termDef: + term: >- + Beta-2 Microglobulin Measurement + source: NCIt + cde_id: C81980 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81980" + term_id: C81980 + term_version: 20.10d + +beta_cell_adenoma: + common: + description: >- + An adenoma arising from the beta cells of the pancreas. It produces insulin. + termDef: + term: >- + Pancreatic Beta Cell Adenoma + source: NCIt + cde_id: C67457 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67457" + term_id: C67457 + term_version: 20.05a + +beta_cell_tumor_malignant: + common: + description: >- + An insulin-producing neuroendocrine tumor arising from the beta cells of the + pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate + secretion of insulin. It displays vascular invasion and metastasizes to other + anatomic sites. + termDef: + term: >- + Malignant Pancreatic Insulinoma + source: NCIt + cde_id: C65186 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65186" + term_id: C65186 + term_version: 20.05a + +betaglucin_gel: + common: + description: >- + A soluble gel containing the beta-glucan betaglucin, with potential immunostimulating + activity. Upon topical administration of the betaglucin gel, betaglucin is able + to increase the number of macrophages and natural killer (NK) cells. NK cells + and macrophages may kill a variety of tumor cells, and virally infected cells. + This may treat human papillomavirus (HPV)-related anogenital warts. + termDef: + term: >- + Betaglucin Gel + source: NCIt + cde_id: C172188 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172188" + term_id: C172188 + term_version: 20.10d + +bexmarilimab: + common: + description: >- + A monoclonal antibody directed against common lymphatic endothelial and vascular + endothelial receptor-1 (CLEVER-1; stabilin-1; FEEL-1), with potential immunomodulatory + and antineoplastic activities. Upon administration, bexmarilimab targets and + binds to CLEVER-1 that is expressed on tumor endothelial cells. This prevents + the recruitment, infiltration and attachment of tumor-associated macrophages + (TAMs) at the tumor site. By preventing the binding of TAMs to tumor cells, + the infiltration of activated T-regulatory cells (Tregs) to the tumor and the + TAM-mediated immune suppression is abrogated, leading to the polarization of + TAM from the immunosuppressive M2 macrophages to the anti-inflammatory and immunostimulatory + M1 macrophages. This leads to the activation of the immune system, resulting + in a cytotoxic T-lymphocyte (CTL)-mediated immune response and inhibition of + tumor cell growth and metastasis. CLEVER-1 is an endothelial cell surface molecule + involved in immune suppression, cancer growth and metastasis. + termDef: + term: >- + Bexmarilimab + source: NCIt + cde_id: C159536 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C159536" + term_id: C159536 + term_version: 20.10d + +bhutan: + common: + description: >- + A country in southern Asia, between China and India, east of Nepal and north + of Bangladesh. + termDef: + term: >- + Bhutan + source: NCIt + cde_id: C16336 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16336" + term_id: C16336 + term_version: 19.12e + +bilateral: + common: + description: >- + Affecting both sides of the body or a matched pair of organs. + termDef: + term: >- + Bilateral + source: NCIt + cde_id: C13332 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13332" + term_id: C13332 + term_version: 20.05a + +bile_duct_adenocarcinoma: + common: + description: >- + An adenocarcinoma arising from the intrahepatic or extrahepatic bile ducts. + termDef: + term: >- + Bile Duct Adenocarcinoma + source: NCIt + cde_id: C27813 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27813" + term_id: C27813 + term_version: 20.05a + +bile_duct_adenoma: + common: + description: >- + A benign, well-demarcated polypoid neoplasm arising from the bile duct epithelium. + According to the growth pattern, it is classified as tubular, papillary, or + tubulopapillary. Adenomas arising from the extrahepatic bile ducts usually produce + symptoms related to biliary obstruction. + termDef: + term: >- + Bile Duct Adenoma + source: NCIt + cde_id: C2942 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2942" + term_id: C2942 + term_version: 20.05a + +bile_duct_cancer: + common: + description: >- + A carcinoma arising from the intrahepatic or extrahepatic bile ducts. + termDef: + term: >- + Bile Duct Carcinoma + source: NCIt + cde_id: C27814 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27814" + term_id: C27814 + term_version: 19.12e + +bile_duct_carcinoma: + common: + description: >- + A carcinoma arising from the intrahepatic or extrahepatic bile ducts. + termDef: + term: >- + Bile Duct Carcinoma + source: NCIt + cde_id: C27814 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27814" + term_id: C27814 + term_version: 20.05a + +bile_duct_cystadenocarcinoma: + common: + description: >- + A mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic + bile ducts and it is associated with an invasive carcinomatous component. + termDef: + term: >- + Bile Duct Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma + source: NCIt + cde_id: C4130 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4130" + term_id: C4130 + term_version: 20.05a + +bile_duct_cystadenoma: + common: + description: >- + An epithelial, usually multiloculated neoplasm arising from the intrahepatic + or extrahepatic bile ducts. It occurs predominantly in females. Signs and symptoms + include abdominal mass, abdominal pain, and jaundice. Morphologically, the cystic + spaces are lined by columnar epithelium and contain mucinous or serous fluid. + termDef: + term: >- + Bile Duct Mucinous Cystic Neoplasm + source: NCIt + cde_id: C4129 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4129" + term_id: C4129 + term_version: 20.05a + +biliary_intraepithelial_neoplasia_grade_3: + common: + description: >- + Biliary intraepithelial neoplasia characterized by the presence of severe epithelial + atypia. + termDef: + term: >- + Biliary Intraepithelial Neoplasia-3 + source: NCIt + cde_id: C67493 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67493" + term_id: C67493 + term_version: 20.05a + +biliary_papillomatosis: + common: + description: >- + A non-invasive, papillary epithelial neoplasm that arises from the epithelium + of the intrahepatic or extrahepatic bile ducts. + termDef: + term: >- + Bile Duct Papillary Neoplasm + source: NCIt + cde_id: C6881 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6881" + term_id: C6881 + term_version: 20.05a + +biliary_tract_nos: + common: + description: >- + The system that transports bile from the hepatocytes in the liver to the small + intestine. It is comprised of the intrahepatic bile ducts, hepatic ducts, common + bile duct, cystic duct, and the gallbladder. + termDef: + term: >- + Biliary Tract + source: NCIt + cde_id: C12678 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12678" + term_id: C12678 + term_version: 20.05a + +biochemical_evidence_of_disease_without_structural_correlate: + common: + description: >- + An indication that biochemical markers of a disease are present but morphological + markers are absent. + termDef: + term: >- + Biochemical Evidence of Disease without Structural Correlate + source: NCIt + cde_id: C165197 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165197" + term_id: C165197 + term_version: 20.05a + +biopsy: + common: + description: >- + The removal of tissue specimens or fluid from the living body for microscopic + examination, performed to establish a diagnosis. + termDef: + term: >- + Biopsy + source: NCIt + cde_id: C15189 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15189" + term_id: C15189 + term_version: 20.05a + +birc3: + common: + description: >- + This anti-apoptotic gene regulates apoptotic activity. BIRC3 gene promotes tumor + cell survival. + termDef: + term: >- + BIRC3 Gene + source: NCIt + cde_id: C20356 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20356" + term_id: C20356 + term_version: 20.10d + +birc6: + common: + description: >- + This gene regulates the apoptotic program via signal transduction in the ubiquitination + pathway. + termDef: + term: >- + BIRC6 Gene + source: NCIt + cde_id: C20352 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20352" + term_id: C20352 + term_version: 20.10d + +bispecific_antibody_agen1223: + common: + description: >- + A bispecific antibody that simultaneously binds to two different and as of yet + undisclosed antigens co-expressed specifically on tumor-infiltrating regulatory + T-cells (Tregs), with potential immunomodulating and antineoplastic activities. + Upon administration, AGEN1223 targets and binds to the two antigens co-expressed + specifically on tumor-infiltrating Tregs. This leads to the selective depletion + of immunosuppressive Tregs in the tumor microenvironment (TME), while sparing + peripheral Tregs and effector T-cells, enhancing the overall antitumor response. + AGEN1223 may also co-stimulate antigen-specific effector T-cells, resulting + in tumor cell death. + termDef: + term: >- + Bispecific Antibody AGEN1223 + source: NCIt + cde_id: C171161 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171161" + term_id: C171161 + term_version: 20.10d + +bispecific_antibody_amg_509: + common: + description: >- + A bispecific antibody that simultaneously binds to two different and as of yet + undisclosed antigens, with potential immunomodulating and antineoplastic activities. + Upon administration, AMG 509 targets and binds to the two antigens. This may + modulate the tumor microenvironment (TME) and may enhance an immune-mediated + antitumor response. + termDef: + term: >- + Bispecific Antibody AMG 509 + source: NCIt + cde_id: C168580 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168580" + term_id: C168580 + term_version: 20.10d + +bispecific_antibody_gs1423: + common: + description: >- + A bispecific antibody that simultaneously binds two different as of yet undisclosed + antigens, with potential immunomodulating and antineoplastic activities. Upon + administration, GS-1423 targets and binds the two antigens. This may modulate + the tumor microenvironment (TME) and may enhance an immune-mediated antitumor + response. + termDef: + term: >- + Bispecific Antibody GS-1423 + source: NCIt + cde_id: C167206 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167206" + term_id: C167206 + term_version: 20.10d + +bite_antibody_amg_910: + common: + description: >- + A half-life extended (HLE), bispecific T-cell engager (BiTE) antibody that simultaneously + binds to two different and as of yet undisclosed antigens, with potential immunomodulating + and antineoplastic activities. Upon administration, AMG 910 targets and binds + to the two antigens. This may modulate the tumor microenvironment (TME) and + may enhance an immune-mediated antitumor response. + termDef: + term: >- + BiTE Antibody AMG 910 + source: NCIt + cde_id: C170815 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170815" + term_id: C170815 + term_version: 20.10d + +bizalimogene_ralaplasmid: + common: + description: >- + A DNA vaccine consisting of plasmids encoding the E6 and E7 genes of human papilloma + virus (HPV) subtypes 16 and 18, respectively, with potential immunostimulating + and antineoplastic activities. Administered via intramuscular electroporation, + bizalimogene ralaplasmid expresses E6 and E7 proteins, which may elicit a cytotoxic + T-lymphocyte (CTL) response against cervical cancer cells expressing E6 and + E7 proteins, resulting in tumor cell lysis. HPV type 16 and HPV type 18 are + the most common HPV types involved in cervical carcinogenesis. + termDef: + term: >- + Bizalimogene Ralaplasmid + source: NCIt + cde_id: C77909 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77909" + term_id: C77909 + term_version: 20.10d + +bizarre_leiomyoma: + common: + description: >- + A morphologic variant of leiomyoma characterized by the presence of pleomorphic + muscle cells with bizarre hyperchromatic nuclei and eosinophilic cytoplasm. + termDef: + term: >- + Bizarre Leiomyoma + source: NCIt + cde_id: C4257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4257" + term_id: C4257 + term_version: 20.05a + +black_adenoma: + common: + description: >- + A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark + brown appearance and is characterized by the presence of neoplastic cells containing + abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome. + termDef: + term: >- + Pigmented Adrenal Cortex Adenoma + source: NCIt + cde_id: C4164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4164" + term_id: C4164 + term_version: 20.05a + +black_or_african_american: + common: + description: >- + A person having origins in any of the Black racial groups of Africa. Terms such + as "Haitian" or "Negro" can be used in addition to "Black or African American". + (OMB) + termDef: + term: >- + Black or African American + source: NCIt + cde_id: C16352 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16352" + term_id: C16352 + term_version: 19.12e + +bladder_cancer: + common: + description: >- + A carcinoma arising from the bladder epithelium. Approximately 90% of the bladder + carcinomas are transitional cell carcinomas. The remainder are squamous cell + carcinomas, adenocarcinomas and small cell neuroendocrine carcinomas. + termDef: + term: >- + Bladder Carcinoma + source: NCIt + cde_id: C4912 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4912" + term_id: C4912 + term_version: 19.12e + +bladder_neck: + common: + description: >- + The inferior portion of the urinary bladder which is formed as the walls of + the bladder converge and become contiguous with the proximal urethra. + termDef: + term: >- + Bladder Neck + source: NCIt + cde_id: C12336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12336" + term_id: C12336 + term_version: 20.05a + +bladder_nos: + common: + description: >- + The distensible sac-like organ that functions as a reservoir of urine, collecting + from the kidneys and eliminating via the urethra. + termDef: + term: >- + Bladder + source: NCIt + cde_id: C12414 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12414" + term_id: C12414 + term_version: 20.05a + +blast_cell_leukemia: + common: + description: >- + A clonal (malignant) hematopoietic disorder with an acute onset, affecting the + bone marrow and the peripheral blood. The malignant cells show minimal differentiation + and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts + (lymphoblasts). + termDef: + term: >- + Acute Leukemia + source: NCIt + cde_id: C9300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9300" + term_id: C9300 + term_version: 20.05a + +blastic_nk_cell_lymphoma: + common: + description: >- + A clinically aggressive neoplasm derived from the precursors of plasmacytoid + dendritic cells (also called professional type I interferon-producing cells + or plasmacytoid monocytes), with a high frequency of cutaneous and bone marrow + involvement and leukemic dissemination. (WHO 2017) + termDef: + term: >- + Blastic Plasmacytoid Dendritic Cell Neoplasm + source: NCIt + cde_id: C7203 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7203" + term_id: C7203 + term_version: 20.05a + +blastic_plasmacytoid_dendritic_cell_neoplasm: + common: + description: >- + A clinically aggressive neoplasm derived from the precursors of plasmacytoid + dendritic cells (also called professional type I interferon-producing cells + or plasmacytoid monocytes), with a high frequency of cutaneous and bone marrow + involvement and leukemic dissemination. (WHO 2017) + termDef: + term: >- + Blastic Plasmacytoid Dendritic Cell Neoplasm + source: NCIt + cde_id: C7203 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7203" + term_id: C7203 + term_version: 20.05a + +blastoma_nos: + common: + description: >- + A rare embryonal neoplasm affecting children. It is associated with DICER1 gene + mutation. This category includes pleuropulmonary blastoma and pituitary gland + blastoma. + termDef: + term: >- + Blastoma + source: NCIt + cde_id: C8997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8997" + term_id: C8997 + term_version: 20.05a + +blm: + common: + description: >- + This gene plays a role in DNA unwinding and recombination-mediated telomere + lengthening. + termDef: + term: >- + BLM Gene + source: NCIt + cde_id: C20805 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20805" + term_id: C20805 + term_version: 20.10d + +blood: + common: + description: >- + A liquid tissue; its major function is to transport oxygen throughout the body. + It also supplies the tissues with nutrients, removes waste products, and contains + various components of the immune system defending the body against infection. + Several hormones also travel in the blood. + termDef: + term: >- + Blood + source: NCIt + cde_id: C12434 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12434" + term_id: C12434 + term_version: 20.05a + +blood_cancer: + common: + description: >- + A malignant tumor that originates from myeloid or lymphoid cells i.e., leukemias + and lymphomas. + termDef: + term: >- + Liquid Tumor + source: NCIt + cde_id: C116915 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116915" + term_id: C116915 + term_version: 19.12e + +blood_draw: + common: + description: >- + A small volume of blood removed for testing or storage. + termDef: + term: >- + Blood Sample + source: NCIt + cde_id: C17610 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17610" + term_id: C17610 + term_version: 20.05a + +blood_urea_nitrogen: + common: + description: >- + A quantitative measurement of the amount of urea nitrogen present in a serum + sample. + termDef: + term: >- + Blood Urea Nitrogen Measurement + source: NCIt + cde_id: C61019 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61019" + term_id: C61019 + term_version: 20.10d + +blue_nevus_malignant: + common: + description: >- + A rare melanoma which develops in a pre-existing blue nevus. It occurs more + frequently on the scalp, face, orbit, back, buttocks, extremities, hands, and + feet. + termDef: + term: >- + Melanoma Arising from Blue Nevus + source: NCIt + cde_id: C4240 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4240" + term_id: C4240 + term_version: 20.05a + +blue_nevus_nos: + common: + description: >- + An intradermal nevus characterized by the presence of benign pigmented dendritic + spindle-shaped melanocytes. It most frequently occurs in the skin of the distal + upper extremities, followed by the lower extremities, scalp, face, and buttocks. + It usually presents as a single blue or blue-black papular lesion less than + 1cm in diameter. Simple excision is usually curative. + termDef: + term: >- + Blue Nevus + source: NCIt + cde_id: C3803 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3803" + term_id: C3803 + term_version: 20.05a + +bmp5: + common: + description: >- + This gene plays a role in the regulation of mesenchymal differentiation. It + is involved in cartilage and bone formation. + termDef: + term: >- + BMP5 Gene + source: NCIt + cde_id: C21353 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21353" + term_id: C21353 + term_version: 20.10d + +bmpr1a: + common: + description: >- + This gene plays a role in the bone morphogenetic protein signaling pathway. + termDef: + term: >- + BMPR1A Gene + source: NCIt + cde_id: C21366 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21366" + term_id: C21366 + term_version: 20.10d + +body_of_pancreas: + common: + description: >- + The part of the pancreas from the point where it crosses the portal vein to + the point where it enters the lienorenal ligament. + termDef: + term: >- + Body of the Pancreas + source: NCIt + cde_id: C12270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12270" + term_id: C12270 + term_version: 20.05a + +body_of_penis: + common: + description: >- + The portion of the penis that extends from the site of attachment to the glans, + and which is covered by skin. It is formed by the joining of the two proximal + free parts of the corpora cavernosa and the related free part of the corpus + spongiosum. + termDef: + term: >- + Body of the Penis + source: NCIt + cde_id: C12325 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12325" + term_id: C12325 + term_version: 20.05a + +body_of_stomach: + common: + description: >- + The main section of the digestive tube that connects the esophagus to the small + intestine. The body proper excludes the upper and lower sections of the fundus + and pyloric portion respectively. + termDef: + term: >- + Body of Stomach + source: NCIt + cde_id: C12258 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12258" + term_id: C12258 + term_version: 20.05a + +bolivia: + common: + description: >- + A country in central South America, southwest of Brazil. + termDef: + term: >- + Bolivia + source: NCIt + cde_id: C16359 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16359" + term_id: C16359 + term_version: 19.12e + +bomedemstat: + common: + description: >- + An orally available, irreversible inhibitor of lysine-specific demethylase 1 + (LSD1), with potential antineoplastic activity. Upon administration, bomedemstat + binds to and inhibits LSD1, a demethylase that suppresses the expression of + target genes by converting the di- and mono-methylated forms of lysine at position + 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances + H3K4 methylation and increases the expression of tumor suppressor genes. In + addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene + expression of tumor promoting genes; thus, inhibition of LSD1 also promotes + H3K9 methylation and decreases transcription of these genes. Altogether, this + may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. + LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent + amine oxidase family is overexpressed in certain tumor cells and plays a key + role in the regulation of gene expression, tumor cell growth and survival. + termDef: + term: >- + Bomedemstat + source: NCIt + cde_id: C131827 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131827" + term_id: C131827 + term_version: 20.10d + +bone: + common: + description: >- + Connective tissue that forms the skeletal components of the body. + termDef: + term: >- + Bone + source: NCIt + cde_id: C12366 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12366" + term_id: C12366 + term_version: 20.05a + +bone_cancer: + common: + description: >- + A primary or metastatic malignant neoplasm affecting the bone or articular cartilage. + termDef: + term: >- + Malignant Bone Neoplasm + source: NCIt + cde_id: C4016 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4016" + term_id: C4016 + term_version: 19.12e + +bone_marrow: + common: + description: >- + The tissue occupying the spaces of bone. It consists of blood vessel sinuses + and a network of hematopoietic cells which give rise to the red cells, white + cells, and megakaryocytes. + termDef: + term: >- + Bone Marrow + source: NCIt + cde_id: C12431 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12431" + term_id: C12431 + term_version: 20.05a + +bone_marrow_aspirate: + common: + description: >- + Aspirate from bone marrow. + termDef: + term: >- + Bone Marrow Aspirate + source: NCIt + cde_id: C133261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C133261" + term_id: C133261 + term_version: 20.05a + +bone_nos: + common: + description: >- + Connective tissue that forms the skeletal components of the body. + termDef: + term: >- + Bone + source: NCIt + cde_id: C12366 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12366" + term_id: C12366 + term_version: 20.05a + +bone_of_limb_nos: + common: + description: >- + A bone within a limb of the body. + termDef: + term: >- + Bone of the Extremity + source: NCIt + cde_id: C32223 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32223" + term_id: C32223 + term_version: 20.05a + +bosnia_and_herzegovina: + common: + description: >- + A country in southeastern Europe, bordering the Adriatic Sea, between Croatia + and Serbia. + termDef: + term: >- + Bosnia and Herzegovina + source: NCIt + cde_id: C16361 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16361" + term_id: C16361 + term_version: 19.12e + +botryoid_sarcoma: + common: + description: >- + A morphologic variant of embryonal rhabdomyosarcoma arising from organs with + a mucosal epithelial surface. It is characterized by the formation of a cambium + layer in the affected tissue and polypoid nodules within an abundant myxoid + stroma. + termDef: + term: >- + Botryoid-Type Embryonal Rhabdomyosarcoma + source: NCIt + cde_id: C9150 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9150" + term_id: C9150 + term_version: 20.05a + +botswana: + common: + description: >- + A country in southern Africa, north of South Africa and east of Namibia. + termDef: + term: >- + Botswana + source: NCIt + cde_id: C16363 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16363" + term_id: C16363 + term_version: 19.12e + +bowen_disease: + common: + description: >- + A form of squamous cell carcinoma in situ. It is a distinct clinicopathological + entity and arises from the skin or the mucocutaneous junction. It affects predominantly + white males in their 6-8th decades of life. Exposed and non-exposed skin sites + are equally affected. UV damage and ingestion of inorganic arsenic may play + a role in the development of the disease. On the skin surface, it presents as + a single or multiple erythematous, scaly, keratotic patches or plaques. The + clinical entity of erythroplasia of Queyrat is regarded as Bowen disease of + the penis and it presents as an asymptomatic, red, circumscribed plaque. Morphologically, + Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, + dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and + display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement + membrane is intact. Complete surgical removal of the lesion may be curative. + termDef: + term: >- + Bowen Disease of the Skin + source: NCIt + cde_id: C62571 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62571" + term_id: C62571 + term_version: 20.05a + +braf: + common: + description: >- + This gene is involved in cell organization/biogenesis and the inhibition of + apoptosis. + termDef: + term: >- + BRAF Gene + source: NCIt + cde_id: C18363 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18363" + term_id: C18363 + term_version: 20.10d + +braf_inhibitor_bgb3245: + common: + description: >- + An orally available inhibitor of both monomer and dimer forms of activating + mutations of the serine/threonine-protein kinase BRAF (B-raf) protein, including + V600 BRAF mutations, non-V600 BRAF mutations, and RAF fusions, with potential + antineoplastic activity. Upon administration, BRAF inhibitor BGB-3245 targets + and binds to both monomeric and dimeric forms of activating BRAF mutations and + fusions. This may result in the inhibition of BRAF-mediated signaling and inhibit + proliferation in tumor cells expressing BRAF mutations and fusions. BRAF belongs + to the RAF family of serine/threonine protein kinases and plays a role in regulating + the mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated + kinase (ERK) signaling pathway, which is often dysregulated in human cancers + and plays a key role in tumor cell proliferation and survival. BRAF mutations + and fusions have been identified in a number of solid tumors and are drivers + of cancer growth. + termDef: + term: >- + BRAF Inhibitor BGB-3245 + source: NCIt + cde_id: C173633 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173633" + term_id: C173633 + term_version: 20.10d + +brafv600e_kinase_inhibitor_abm1310: + common: + description: >- + An orally bioavailable, small molecule inhibitor of mutant (V600E) v-raf murine + sarcoma viral oncogene homolog B1 (BRAF) with potential antineoplastic activity. + Upon oral administration, BRAF(V600E) kinase inhibitor ABM-1310 selectively + binds to and inhibits the activity of BRAF(V600E) kinase, which may result in + the inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) + kinase-expressing tumor cells and a reduction in tumor cell proliferation. BRAF + belongs to the raf/mil family of serine/threonine protein kinases and plays + a role in regulating the MAP kinase/ERKs signaling pathway. The valine to glutamic + acid substitution at residue 600 accounts for about 90% of BRAF gene mutations. + The oncogenic product, BRAF(V600E) kinase, exhibits a markedly elevated activity + that over-activates the MAPK signaling pathway. The BRAF(V600E) mutation has + been found to occur in about 8% of all tumors. + termDef: + term: >- + BRAF(V600E) Kinase Inhibitor ABM-1310 + source: NCIt + cde_id: C170951 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170951" + term_id: C170951 + term_version: 20.10d + +brain: + common: + description: >- + An organ composed of grey and white matter containing billions of neurons that + is the center for intelligence and reasoning. It is protected by the bony cranium. + termDef: + term: >- + Brain + source: NCIt + cde_id: C12439 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12439" + term_id: C12439 + term_version: 20.05a + +brain_cancer: + common: + description: >- + A primary or metastatic malignant neoplasm affecting the brain. + termDef: + term: >- + Malignant Brain Neoplasm + source: NCIt + cde_id: C3568 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3568" + term_id: C3568 + term_version: 19.12e + +brain_nos: + common: + description: >- + An organ composed of grey and white matter containing billions of neurons that + is the center for intelligence and reasoning. It is protected by the bony cranium. + termDef: + term: >- + Brain + source: NCIt + cde_id: C12439 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12439" + term_id: C12439 + term_version: 20.05a + +brain_stem: + common: + description: >- + Three sections, the midbrain, pons and medulla oblongata, that are located at + the base of the brain. The brain stem regulates the central nervous system, + and is vital as a conduit for motor and sensory innervations. + termDef: + term: >- + Brain Stem + source: NCIt + cde_id: C12441 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12441" + term_id: C12441 + term_version: 20.05a + +branchial_cleft: + common: + description: >- + A congenital defect in the neck that occurs during early embryonic development. It + is caused by developmental abnormalities of the pharyngeal arches and results + in the development of a cyst or a fissure in the side of the neck. + termDef: + term: >- + Branchial Cleft Remnant + source: NCIt + cde_id: C104813 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104813" + term_id: C104813 + term_version: 20.05a + +brazil: + common: + description: >- + A country in eastern South America, bordering the Atlantic Ocean. + termDef: + term: >- + Brazil + source: NCIt + cde_id: C16364 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16364" + term_id: C16364 + term_version: 19.12e + +brca1: + common: + description: >- + This gene plays a role in cell cycle control, regulation of transcription and + the maintenance of genomic stability. It is also involved in the inhibition + of mammary cell growth. + termDef: + term: >- + BRCA1 Gene + source: NCIt + cde_id: C17965 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17965" + term_id: C17965 + term_version: 20.10d + +brca2: + common: + description: >- + This gene is involved in cell cycle control, DNA repair and the maintenance + of genomic stability. It also plays a role in the proliferation of embryonic + cells. + termDef: + term: >- + BRCA2 Gene + source: NCIt + cde_id: C18120 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18120" + term_id: C18120 + term_version: 20.10d + +brd3: + common: + description: >- + This gene may play a role in both histone acetylation and transcriptional regulation. + termDef: + term: >- + BRD3 Gene + source: NCIt + cde_id: C97397 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97397" + term_id: C97397 + term_version: 20.10d + +brd4: + common: + description: >- + This gene plays a role in mitosis. + termDef: + term: >- + BRD4 Gene + source: NCIt + cde_id: C92702 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92702" + term_id: C92702 + term_version: 20.10d + +breast_cancer: + common: + description: >- + A carcinoma arising from the breast, most commonly the terminal ductal-lobular + unit. It is the most common malignant tumor in females. Risk factors include + country of birth, family history, menstrual and reproductive history, fibrocystic + disease and epithelial hyperplasia, exogenous estrogens, contraceptive agents, + and ionizing radiation. The vast majority of breast carcinomas are adenocarcinomas + (ductal or lobular). Breast carcinoma spreads by direct invasion, by the lymphatic + route, and by the blood vessel route. The most common site of lymph node involvement + is the axilla. + termDef: + term: >- + Breast Carcinoma + source: NCIt + cde_id: C4872 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4872" + term_id: C4872 + term_version: 19.12e + +breast_nos: + common: + description: >- + One of two hemispheric projections of variable size situated in the subcutaneous + layer over the pectoralis major muscle on either side of the chest. + termDef: + term: >- + Breast + source: NCIt + cde_id: C12971 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12971" + term_id: C12971 + term_version: 20.05a + +brenner_tumor_borderline_malignancy: + common: + description: >- + A transitional cell neoplasm of low malignant potential arising from the ovary. It + is characterized by the presence of neoplastic transitional cells with atypical + or malignant features without evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Brenner Tumor/Atypical Proliferative Ovarian Brenner Tumor + source: NCIt + cde_id: C9459 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9459" + term_id: C9459 + term_version: 20.05a + +brenner_tumor_malignant: + common: + description: >- + A malignant neoplasm that arises from the ovary and is characterized by the + presence of an invasive malignant transitional cell component and nests of benign + transitional cells in a fibrotic stroma. When the neoplasm is confined to the + ovary, the prognosis is good. + termDef: + term: >- + Malignant Ovarian Brenner Tumor + source: NCIt + cde_id: C4270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4270" + term_id: C4270 + term_version: 20.05a + +brenner_tumor_nos: + common: + description: >- + A usually benign tumor composed of solid and cystic nests of epithelial cells + resembling transitional epithelium; it is surrounded by an abundant stromal + component that is dense and fibroblastic in nature. + termDef: + term: >- + Brenner Tumor + source: NCIt + cde_id: C39954 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39954" + term_id: C39954 + term_version: 20.05a + +brenner_tumor_proliferating: + common: + description: >- + A transitional cell neoplasm of low malignant potential arising from the ovary. It + is characterized by the presence of neoplastic transitional cells with atypical + or malignant features without evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Brenner Tumor/Atypical Proliferative Ovarian Brenner Tumor + source: NCIt + cde_id: C9459 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9459" + term_id: C9459 + term_version: 20.05a + +brip1: + common: + description: >- + This gene is involved in DNA double-strand break repair. + termDef: + term: >- + BRIP1 Gene + source: NCIt + cde_id: C63526 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63526" + term_id: C63526 + term_version: 20.10d + +broad_ligament: + common: + description: >- + A wide fold of peritoneum that connects the uterus to the lateral walls and + floor of the pelvis, and contains the ovaries, fallopian tubes, ovarian ligaments, + round ligament of the uterus, and ovarian and uterine arteries. + termDef: + term: >- + Broad Ligament + source: NCIt + cde_id: C12318 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12318" + term_id: C12318 + term_version: 20.05a + +bronchial_adenoma_nos: + common: + description: >- + A benign lung neoplasm characterized by the presence of a fibrovascular stroma + lined by cuboidal to columnar cells. Patients are usually asymptomatic and it + is incidentally discovered as a pulmonary nodule during chest X-ray examination. + Surgical excision is curative. + termDef: + term: >- + Lung Papillary Adenoma + source: NCIt + cde_id: C3494 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3494" + term_id: C3494 + term_version: 20.05a + +bronchialassociated_lymphoid_tissue_lymphoma: + common: + description: >- + An extranodal marginal zone lymphoma that arises from the lung. It is characterized + by the neoplastic proliferation of small B-lymphocytes, monocytoid cells and + cells with plasma cell differentiation in the marginal zones of reactive lymphoid + follicles. The neoplastic cells infiltrate the interfollicular areas and the + bronchial epithelium forming lymphoepithelial lesions. The neoplasm is usually + discovered as a mass in a chest x-ray in asymptomatic patients. When symptoms + occur, they include cough, dyspnea, hemoptysis, and chest pain. If the lung + lesions are resectable, surgery can result in prolonged remission. + termDef: + term: >- + Bronchial Mucosa-Associated Lymphoid Tissue Lymphoma + source: NCIt + cde_id: C5264 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5264" + term_id: C5264 + term_version: 20.05a + +bronchioalveolar_carcinoma_mixed_mucinous_and_nonmucinous: + common: + description: >- + A rare morphologic variant of bronchiolo-alveolar lung carcinoma characterized + by the presence of both mucin and non-mucin producing cells. + termDef: + term: >- + Mixed Mucinous and Non-Mucinous Bronchioloalveolar Carcinoma + source: NCIt + cde_id: C7270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7270" + term_id: C7270 + term_version: 20.05a + +bronchioalveolar_carcinoma_mucinous: + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by tall columnar cells and mucin production. + termDef: + term: >- + Minimally Invasive Lung Mucinous Adenocarcinoma + source: NCIt + cde_id: C7268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7268" + term_id: C7268 + term_version: 20.05a + +bronchiolar_adenocarcinoma: + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +bronchiolar_carcinoma: + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +bronchioloalveolar_adenocarcinoma_nos: + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +bronchioloalveolar_carcinoma_clara_cell: + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by the presence of Clara cells and/or type II cells. + termDef: + term: >- + Minimally Invasive Lung Non-Mucinous Adenocarcinoma + source: NCIt + cde_id: C7269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7269" + term_id: C7269 + term_version: 20.05a + +bronchioloalveolar_carcinoma_clara_cell_and_goblet_cell_type: + common: + description: >- + A rare morphologic variant of bronchiolo-alveolar lung carcinoma characterized + by the presence of both mucin and non-mucin producing cells. + termDef: + term: >- + Mixed Mucinous and Non-Mucinous Bronchioloalveolar Carcinoma + source: NCIt + cde_id: C7270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7270" + term_id: C7270 + term_version: 20.05a + +bronchioloalveolar_carcinoma_goblet_cell_type: + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by tall columnar cells and mucin production. + termDef: + term: >- + Minimally Invasive Lung Mucinous Adenocarcinoma + source: NCIt + cde_id: C7268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7268" + term_id: C7268 + term_version: 20.05a + +bronchioloalveolar_carcinoma_indeterminate_type: + common: + description: >- + A rare morphologic variant of bronchiolo-alveolar lung carcinoma characterized + by the presence of both mucin and non-mucin producing cells. + termDef: + term: >- + Mixed Mucinous and Non-Mucinous Bronchioloalveolar Carcinoma + source: NCIt + cde_id: C7270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7270" + term_id: C7270 + term_version: 20.05a + +bronchioloalveolar_carcinoma_nonmucinous: + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by the presence of Clara cells and/or type II cells. + termDef: + term: >- + Minimally Invasive Lung Non-Mucinous Adenocarcinoma + source: NCIt + cde_id: C7269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7269" + term_id: C7269 + term_version: 20.05a + +bronchioloalveolar_carcinoma_nos: + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +bronchioloalveolar_carcinoma_type_ii_pneumocyte: + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by the presence of Clara cells and/or type II cells. + termDef: + term: >- + Minimally Invasive Lung Non-Mucinous Adenocarcinoma + source: NCIt + cde_id: C7269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7269" + term_id: C7269 + term_version: 20.05a + +bronchioloalveolar_carcinoma_type_ii_pneumocyte_and_goblet_cell_type: + common: + description: >- + A rare morphologic variant of bronchiolo-alveolar lung carcinoma characterized + by the presence of both mucin and non-mucin producing cells. + termDef: + term: >- + Mixed Mucinous and Non-Mucinous Bronchioloalveolar Carcinoma + source: NCIt + cde_id: C7270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7270" + term_id: C7270 + term_version: 20.05a + +brooke_tumor: + common: + description: >- + A benign hair follicle neoplasm with trichoblastic differentiation. It usually + presents as a solitary papular lesion It most often presents on the head and + neck area, but it may develop in any anatomic site containing hair follicles. + Because of its benign nature, treatment usually is not required, provided that + the diagnosis has been established with certainty. + termDef: + term: >- + Trichoblastoma + source: NCIt + cde_id: C27132 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27132" + term_id: C27132 + term_version: 20.05a + +brother: + common: + description: >- + A male sibling. + termDef: + term: >- + Brother + source: NCIt + cde_id: C25289 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25289" + term_id: C25289 + term_version: 19.12e + +brotherinlaw: + common: + description: >- + A brother by marriage. + termDef: + term: >- + Brother-in-law + source: NCIt + cde_id: C71406 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71406" + term_id: C71406 + term_version: 19.12e + +brown_fat_tumor: + common: + description: >- + A rare benign slow growing adipose tissue tumor, characterized by the presence + of polygonal brown fat cells with multivacuolated and/or granular cytoplasm. The + tumor is usually painless and is most often seen in young adults. + termDef: + term: >- + Hibernoma + source: NCIt + cde_id: C3702 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3702" + term_id: C3702 + term_version: 20.05a + +brunei: + common: + description: >- + A country in southeastern Asia, bordering the South China Sea and surrounded + by Malaysia. + termDef: + term: >- + Brunei + source: NCIt + cde_id: C16367 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16367" + term_id: C16367 + term_version: 19.12e + +btg1: + common: + description: >- + This gene is involved in the regulation of cell proliferation. + termDef: + term: >- + BTG1 Gene + source: NCIt + cde_id: C80101 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80101" + term_id: C80101 + term_version: 20.10d + +btk: + common: + description: >- + This gene is involved in both signaling and B-cell development. + termDef: + term: >- + BTK Gene + source: NCIt + cde_id: C75013 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75013" + term_id: C75013 + term_version: 20.10d + +btk_inhibitor_hza018: + common: + description: >- + An orally bioavailable inhibitor of Bruton's tyrosine kinase (BTK), with potential + antineoplastic activity. Upon administration, BTK inhibitor HZ-A-018 targets, + binds to and inhibits the activity of BTK and prevents the activation of the + B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation + and BTK-mediated activation of downstream survival pathways. This leads to an + inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member + of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed + in B-cell malignancies; it plays an important role in B lymphocyte development, + activation, signaling, proliferation and survival. + termDef: + term: >- + BTK Inhibitor HZ-A-018 + source: NCIt + cde_id: C174394 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174394" + term_id: C174394 + term_version: 20.10d + +bub1b: + common: + description: >- + This gene is involved in mitotic progression. + termDef: + term: >- + BUB1B Gene + source: NCIt + cde_id: C95592 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95592" + term_id: C95592 + term_version: 20.10d + +buccal_mucosa: + common: + description: >- + The mucosal membranes located on the inside of the cheek, in the buccal cavity. + termDef: + term: >- + Buccal Mucosa + source: NCIt + cde_id: C12505 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12505" + term_id: C12505 + term_version: 20.10d + +buffy_coat: + common: + description: >- + The middle layer of an anticoagulated blood specimen following separation by + centrifugation. It contains most of the white blood cells and platelets. + termDef: + term: >- + Buffy Coat + source: NCIt + cde_id: C84507 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84507" + term_id: C84507 + term_version: 20.10d + +bulgaria: + common: + description: >- + A country in southeastern Europe, bordering the Black Sea, between Romania and + Turkey. + termDef: + term: >- + Bulgaria + source: NCIt + cde_id: C16368 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16368" + term_id: C16368 + term_version: 19.12e + +burkina_faso: + common: + description: >- + A country in western Africa, between Mali and Ghana. + termDef: + term: >- + Burkina Faso + source: NCIt + cde_id: C16369 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16369" + term_id: C16369 + term_version: 19.12e + +burkitt_cell_leukemia: + common: + description: >- + The leukemic counterpart of Burkitt's lymphoma. The characteristic Burkitt cells + are seen in the bone marrow and the peripheral blood. This is an aggressive + leukemia. + termDef: + term: >- + Burkitt Leukemia + source: NCIt + cde_id: C7400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7400" + term_id: C7400 + term_version: 20.05a + +burkitt_lymphoma_nos_includes_all_variants: + common: + description: >- + A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with + basophilic cytoplasm and numerous mitotic figures. It is often associated with + the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three + morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma + with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All + cases express the MYC translocation [t(8;14)]. (WHO, 2001) + termDef: + term: >- + Burkitt Lymphoma + source: NCIt + cde_id: C2912 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2912" + term_id: C2912 + term_version: 20.05a + +burkitt_tumor: + common: + description: >- + A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with + basophilic cytoplasm and numerous mitotic figures. It is often associated with + the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three + morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma + with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All + cases express the MYC translocation [t(8;14)]. (WHO, 2001) + termDef: + term: >- + Burkitt Lymphoma + source: NCIt + cde_id: C2912 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2912" + term_id: C2912 + term_version: 20.05a + +burkittlike_lymphoma: + common: + description: >- + A morphologic variant of Burkitt lymphoma characterized by marked nuclear pleomorphism, + abundant apoptotic debris, and the presence of tangible body macrophages. + termDef: + term: >- + Atypical Burkitt/Burkitt-Like Lymphoma + source: NCIt + cde_id: C6917 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6917" + term_id: C6917 + term_version: 20.05a + +burning_tree_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when trees are undergoing combustion. + termDef: + term: >- + Burning Tree Smoke + source: NCIt + cde_id: C164075 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164075" + term_id: C164075 + term_version: 19.12e + +burundi: + common: + description: >- + A country in central Africa, east of the Democratic Republic of the Congo and + south of Rwanda. + termDef: + term: >- + Burundi + source: NCIt + cde_id: C16371 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16371" + term_id: C16371 + term_version: 19.12e + +c: + common: + description: >- + Child-Pugh score indicating one-year survival of 45% in patients with chronic + liver disease and cirrhosis. This score is determined by the study of the following + five factors: bilirubin, albumin, international normalized ratio, presence and + degree of ascites, and presence and degree of encephalopathy. + termDef: + term: >- + Child-Pugh Class C + source: NCIt + cde_id: C113694 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113694" + term_id: C113694 + term_version: 20.05a + +c_cell_carcinoma: + common: + description: >- + A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It + is closely associated with multiple endocrine neoplasia syndromes. Approximately + 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present + with a thyroid nodule that is painless and firm. In the majority of cases nodal + involvement is present at diagnosis. Surgery is the preferred treatment for + both primary lesions and recurrences. This carcinoma is generally not very + sensitive to radiation and almost unresponsive to chemotherapy. + termDef: + term: >- + Thyroid Gland Medullary Carcinoma + source: NCIt + cde_id: C3879 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3879" + term_id: C3879 + term_version: 20.05a + +c10: + common: + description: >- + A total score of 10 for hepatic function, corresponding to class C in the Child-Pugh + classification. + termDef: + term: >- + Child-Pugh Class C10 + source: NCIt + cde_id: C146795 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146795" + term_id: C146795 + term_version: 20.05a + +c11: + common: + description: >- + A total score of 11 for hepatic function, corresponding to class C in the Child-Pugh + classification. + termDef: + term: >- + Child-Pugh Class C11 + source: NCIt + cde_id: C146796 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146796" + term_id: C146796 + term_version: 20.05a + +c12: + common: + description: >- + A total score of 12 for hepatic function, corresponding to class C in the Child-Pugh + classification. + termDef: + term: >- + Child-Pugh Class C12 + source: NCIt + cde_id: C146797 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146797" + term_id: C146797 + term_version: 20.05a + +c15orf65: + common: + description: >- + This gene has no known function. + termDef: + term: >- + C15orf65 Gene + source: NCIt + cde_id: C98096 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98096" + term_id: C98096 + term_version: 20.10d + +ca125: + common: + description: >- + A substance that may be found in high amounts in the blood of patients with + certain types of cancer, including ovarian cancer. CA-125 levels may also help + monitor how well cancer treatments are working or if cancer has come back. + termDef: + term: >- + CA-125 Antigen + source: NCIt + cde_id: C325 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C325" + term_id: C325 + term_version: 20.10d + +ca199: + common: + description: >- + CA 19-9 is a fucosylated glycosphingolipid carbohydrate antigen that is soluble + and is adsorbed to erythrocytes and to many adenocarcinomas of the digestive + tract, especially pancreatic tumors. By structure CA 19-9 is related to the + Lewis blood group antigens. + termDef: + term: >- + CA19-9 Antigen + source: NCIt + cde_id: C327 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C327" + term_id: C327 + term_version: 20.10d + +cacna1d: + common: + description: >- + This gene is involved in voltage-dependent calcium transport. + termDef: + term: >- + CACNA1D Gene + source: NCIt + cde_id: C113769 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113769" + term_id: C113769 + term_version: 20.10d + +calcifying_epithelial_odontogenic_tumor: + common: + description: >- + A slow growing, locally invasive neoplasm arising from tooth-forming tissues. + It most often grows intraosseously in the mandible and less frequently in the + maxilla. In a minority of cases it grows extraosseously in the gingiva. It is + characterized by the presence of a fibrous stroma, epithelial cells with abundant + eosinophilic cytoplasm, and amyloid material which is often calcified. Small + tumors may be successfully treated with enucleation. Local resection is usually + required for larger tumors. Recurrences have been reported in a minority of + cases. + termDef: + term: >- + Calcifying Epithelial Odontogenic Tumor + source: NCIt + cde_id: C54301 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54301" + term_id: C54301 + term_version: 20.05a + +calcifying_epithelioma_of_malherbe: + common: + description: >- + A benign adnexal neoplasm arising from hair-bearing skin surfaces, usually the + head and neck and upper extremities. It usually presents as a solitary, slow-growing + nodular mass. Morphologically, it displays differentiation towards the matrix + and inner sheath of the normal hair follicle and the hair cortex. Complete surgical + excision is usually curative. Occasionally, it may recur. + termDef: + term: >- + Pilomatricoma + source: NCIt + cde_id: C7368 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7368" + term_id: C7368 + term_version: 20.05a + +calcifying_odontogenic_cyst: + common: + description: >- + A benign, intraosseous or extraosseous cystic neoplasm arising from tooth-forming + tissues. It is characterized by the presence of a cyst lined by an ameloblastoma-like + epithelium and ghost cells formation. The ghost cells may undergo calcification. + It is treated with enucleation. Few recurrences have been reported for intraosseous + neoplasms whereas no recurrences have been reported for extraosseous neoplasms. + termDef: + term: >- + Calcifying Cystic Odontogenic Tumor + source: NCIt + cde_id: C54319 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54319" + term_id: C54319 + term_version: 20.05a + +calcium: + common: + description: >- + A quantitative measurement of the amount of calcium present in a sample. + termDef: + term: >- + Calcium Measurement + source: NCIt + cde_id: C64488 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64488" + term_id: C64488 + term_version: 20.10d + +calcium_releaseactivated_channel_inhibitor_cm4620: + common: + description: >- + A calcium (Ca2+) release-activated channel (CRAC) inhibitor, with potential + anti-inflammatory and protective activities. Upon administration, CM4620 targets, + binds to and inhibits the calcium release-activated calcium channel protein + 1 (Orai1), which forms the pore of CRAC, and is expressed on both parenchymal + cells and immune cells. This prevents the transport of extracellular Ca2+ into + the cell and inhibits the subsequent activation of Ca2+-mediated signaling and + transcription of target genes. This may prevent Ca2+ entry-mediated cell death. + It may also inhibit the proliferation of immune cells and prevents the release + of various inflammatory cytokines in immune cells, such as interleukin-2 (IL-2) + and tumor necrosis factor-alpha (TNF-a). This may lead to a reduction of inflammatory + responses in inflammatory-mediated diseases. CRACs, specialized plasma membrane + Ca2+ ion channels composed of the plasma membrane based Orai channels and the + endoplasmic reticulum (ER) stromal interaction molecules (STIMs), mediate store + operated Ca2+ entry (SOCE) and play a key role in calcium homeostasis. CRACs + are overactivated in a variety of cell types, especially certain immune cells + during inflammation, including T-lymphocytes, neutrophils and macrophages. + termDef: + term: >- + Calcium Release-activated Channel Inhibitor CM4620 + source: NCIt + cde_id: C166417 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166417" + term_id: C166417 + term_version: 20.10d + +call: + common: + description: >- + Common Acute Lymphoblastic Leukemia + termDef: + term: >- + Common Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27797 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27797" + term_id: C27797 + term_version: 20.05a + +calr: + common: + description: >- + This gene plays a role in calcium binding and protein folding. + termDef: + term: >- + CALR Gene + source: NCIt + cde_id: C95313 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95313" + term_id: C95313 + term_version: 20.10d + +cambodia: + common: + description: >- + A country in southeastern Asia, bordering the Gulf of Thailand, between Thailand, + Vietnam, and Laos. + termDef: + term: >- + Cambodia + source: NCIt + cde_id: C16378 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16378" + term_id: C16378 + term_version: 19.12e + +cameroon: + common: + description: >- + A country in western Africa, bordering the Gulf of Guinea, between Equatorial + Guinea and Nigeria. + termDef: + term: >- + Cameroon + source: NCIt + cde_id: C16379 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16379" + term_id: C16379 + term_version: 19.12e + +camidanlumab_tesirine: + common: + description: >- + An immunoconjugate consisting of a human immunoglobulin (Ig) G1 monoclonal antibody + directed against the alpha subunit of the interleukin-2 receptor (IL-2R alpha + or CD25) and conjugated, via a cleavable linker, to a synthetic, cross-linking + agent pyrrolobenzodiazepine (PBD) dimer that targets DNA minor grooves, with + potential antineoplastic activity. The monoclonal antibody portion of the anti-CD25 + antibody-drug conjugate (ADC) ADCT-301 specifically binds to the cell surface + antigen CD25. This causes the internalization of ADCT-301 and the subsequent + release of the cytotoxic PBD moiety. The imine groups of the PBD moiety bind + to the N2 positions of guanines on opposite strands of DNA. This induces interstrand + cross-links in the minor groove of DNA and inhibits DNA replication, which inhibits + the proliferation of CD25-overexpressing tumor cells. CD25, a transmembrane + receptor and tumor-associated antigen (TAA), is expressed on certain cancer + cells. + termDef: + term: >- + Camidanlumab Tesirine + source: NCIt + cde_id: C121949 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121949" + term_id: C121949 + term_version: 20.10d + +camta1: + common: + description: >- + This gene is involved in both DNA binding and transcription. + termDef: + term: >- + CAMTA1 Gene + source: NCIt + cde_id: C101440 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101440" + term_id: C101440 + term_version: 20.10d + +canada: + common: + description: >- + A country in northern North America, bordering the North Atlantic Ocean on the + east, North Pacific Ocean on the west, and the Arctic Ocean on the north, north + of the conterminous US. + termDef: + term: >- + Canada + source: NCIt + cde_id: C16380 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16380" + term_id: C16380 + term_version: 19.12e + +cancer: + common: + description: >- + A tumor composed of atypical neoplastic, often pleomorphic cells that invade + other tissues. Malignant neoplasms often metastasize to distant anatomic sites + and may recur after excision. The most common malignant neoplasms are carcinomas, + Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. + termDef: + term: >- + Malignant Neoplasm + source: NCIt + cde_id: C9305 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9305" + term_id: C9305 + term_version: 19.12e + +cancer_related: + common: + description: >- + An indication or description that a relationship to cancer exists. + termDef: + term: >- + Related to Cancer + source: NCIt + cde_id: C82561 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82561" + term_id: C82561 + term_version: 19.12e + +cant1: + common: + description: >- + This gene plays a role in both nucleotide hydrolysis and signal transduction. + termDef: + term: >- + CANT1 Gene + source: NCIt + cde_id: C97375 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97375" + term_id: C97375 + term_version: 20.10d + +cape_verde: + common: + description: >- + A group of islands in the North Atlantic Ocean, west of Senegal. + termDef: + term: >- + Cape Verde + source: NCIt + cde_id: C16382 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16382" + term_id: C16382 + term_version: 19.12e + +capillary_hemangioma: + common: + description: >- + A common hemangioma characterized by the presence of capillary-sized vascular + channels without prominent epithelioid endothelial cells. + termDef: + term: >- + Capillary Hemangioma + source: NCIt + cde_id: C7457 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7457" + term_id: C7457 + term_version: 20.05a + +carbon_c_14pamiparib: + common: + description: >- + An orally bioavailable radioconjugate composed of pamiparib, a nuclear enzyme + poly(ADP-ribose) polymerase (PARP) inhibitor, radiolabeled with the radioisotope + carbon C 14, with potential use for evaluating the pharmacokinetic profile of + pamiparib. Pamiparib targets, binds to and inhibits PARP, which results in the + inhibition of tumor cell proliferation and survival. Labeling of pamiparib with + the radioactive tracer carbon C 14 allows for the evaluation of pamiparib's + pharmacokinetic profile, including its absorption, distribution, metabolism + and excretion (ADME). + termDef: + term: >- + Carbon C 14-pamiparib + source: NCIt + cde_id: C173441 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173441" + term_id: C173441 + term_version: 20.10d + +carcinoid_nos: + common: + description: >- + A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal + cells having monotonous, centrally located nuclei and small nucleoli, infrequent + mitoses, and no necrosis. The tumor may show a variety of patterns, such as + solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical + studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology + (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, + and mitoses) can occasionally be seen. Such cases may have an aggressive clinical + course. Gastrointestinal tract and lung are common sites of involvement. + termDef: + term: >- + Carcinoid Tumor + source: NCIt + cde_id: C2915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2915" + term_id: C2915 + term_version: 20.05a + +carcinoid_tumor_nos: + common: + description: >- + A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal + cells having monotonous, centrally located nuclei and small nucleoli, infrequent + mitoses, and no necrosis. The tumor may show a variety of patterns, such as + solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical + studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology + (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, + and mitoses) can occasionally be seen. Such cases may have an aggressive clinical + course. Gastrointestinal tract and lung are common sites of involvement. + termDef: + term: >- + Carcinoid Tumor + source: NCIt + cde_id: C2915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2915" + term_id: C2915 + term_version: 20.05a + +carcinoid_tumor_of_uncertain_malignant_potential: + common: + description: >- + A carcinoid tumor that shows atypical characteristics and has borderline malignant + potential. + termDef: + term: >- + Carcinoid Tumor of Uncertain Malignant Potential + source: NCIt + cde_id: C65196 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65196" + term_id: C65196 + term_version: 20.05a + +carcinoma_anaplastic_nos: + common: + description: >- + A usually aggressive malignant epithelial neoplasm composed of atypical cells + which do not display evidence of glandular, squamous, or transitional cell differentiation. + termDef: + term: >- + Undifferentiated Carcinoma + source: NCIt + cde_id: C3692 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3692" + term_id: C3692 + term_version: 20.05a + +carcinoma_diffuse_type: + common: + description: >- + An adenocarcinoma characterized by the presence of a diffuse cellular infiltrate + which is composed of poorly cohesive cells with minimal or no glandular formations. + Representative example is the gastric diffuse adenocarcinoma. + termDef: + term: >- + Diffuse Type Adenocarcinoma + source: NCIt + cde_id: C4127 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4127" + term_id: C4127 + term_version: 20.05a + +carcinoma_in_a_polyp_nos: + common: + description: >- + Carcinoma arising in a polyp. + termDef: + term: >- + Carcinoma in a Polyp + source: NCIt + cde_id: C7682 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7682" + term_id: C7682 + term_version: 20.05a + +carcinoma_in_adenomatous_polyp: + common: + description: >- + A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular + cells in an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma in Adenomatous Polyp + source: NCIt + cde_id: C7676 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7676" + term_id: C7676 + term_version: 20.05a + +carcinoma_in_pleomorphic_adenoma: + common: + description: >- + A carcinoma arising in a pre-existing pleomorphic adenoma. It most often occurs + in the parotid gland and less often in the submandibular gland and minor salivary + gland. Patients usually present with a history of a long-standing mass which + recently had undergone rapid growth. The prognosis depends on the invasiveness + of the malignant component. Patients with non-invasive or minimally invasive + tumors usually have a good prognosis following surgical resection. Invasive + tumors are usually aggressive and are associated with recurrences and metastases. + termDef: + term: >- + Carcinoma ex Pleomorphic Adenoma + source: NCIt + cde_id: C4397 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4397" + term_id: C4397 + term_version: 20.05a + +carcinoma_in_situ_in_a_polyp_nos: + common: + description: >- + An intraepithelial adenocarcinoma arising in a polyp. + termDef: + term: >- + Carcinoma In Situ in a Polyp + source: NCIt + cde_id: C7681 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7681" + term_id: C7681 + term_version: 20.05a + +carcinoma_in_situ_in_adenomatous_polyp: + common: + description: >- + A non-invasive adenocarcinoma arising from the neoplastic glandular cells in + an adenomatous polyp. + termDef: + term: >- + Adenocarcinoma In Situ in Adenomatous Polyp + source: NCIt + cde_id: C7678 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7678" + term_id: C7678 + term_version: 20.05a + +carcinoma_in_situ_nos: + common: + description: >- + A malignant epithelial neoplasm which is confined to the epithelial layer without + evidence of further tissue invasion. + termDef: + term: >- + Carcinoma In Situ + source: NCIt + cde_id: C2917 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2917" + term_id: C2917 + term_version: 20.05a + +carcinoma_intestinal_type: + common: + description: >- + An adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. + Representative examples include gastric, gallbladder, and ampulla of Vater intestinal + type adenocarcinomas. + termDef: + term: >- + Intestinal-Type Adenocarcinoma + source: NCIt + cde_id: C4126 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4126" + term_id: C4126 + term_version: 20.05a + +carcinoma_metastatic_nos: + common: + description: >- + A carcinoma that has spread from its original site of growth to other anatomic + sites. + termDef: + term: >- + Metastatic Carcinoma + source: NCIt + cde_id: C3482 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3482" + term_id: C3482 + term_version: 20.05a + +carcinoma_nos: + common: + description: >- + A malignant tumor arising from epithelial cells. Carcinomas that arise from + glandular epithelium are called adenocarcinomas, those that arise from squamous + epithelium are called squamous cell carcinomas, and those that arise from transitional + epithelium are called transitional cell carcinomas. Morphologically, the malignant + epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. + Carcinomas are graded by the degree of cellular differentiation as well, moderately, + or poorly differentiated. Carcinomas invade the surrounding tissues and tend + to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast + carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen + carcinomas. + termDef: + term: >- + Carcinoma + source: NCIt + cde_id: C2916 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2916" + term_id: C2916 + term_version: 20.05a + +carcinoma_showing_thymuslike_differentiation: + common: + description: >- + A rare primary carcinoma of the thyroid gland, composed of groups of carcinoma + cells with thymic epithelial differentiation. + termDef: + term: >- + Intrathyroid Thymic Carcinoma + source: NCIt + cde_id: C46106 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46106" + term_id: C46106 + term_version: 20.05a + +carcinoma_showing_thymuslike_element: + common: + description: >- + A rare primary carcinoma of the thyroid gland, composed of groups of carcinoma + cells with thymic epithelial differentiation. + termDef: + term: >- + Intrathyroid Thymic Carcinoma + source: NCIt + cde_id: C46106 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46106" + term_id: C46106 + term_version: 20.05a + +carcinoma_simplex: + common: + description: >- + An undifferentiated malignant epithelial neoplasm which tends to infiltrate + the surrounding tissues and spread to other anatomic sites. + termDef: + term: >- + Carcinoma Simplex + source: NCIt + cde_id: C65195 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65195" + term_id: C65195 + term_version: 20.05a + +carcinoma_undifferentiated_nos: + common: + description: >- + A usually aggressive malignant epithelial neoplasm composed of atypical cells + which do not display evidence of glandular, squamous, or transitional cell differentiation. + termDef: + term: >- + Undifferentiated Carcinoma + source: NCIt + cde_id: C3692 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3692" + term_id: C3692 + term_version: 20.05a + +carcinoma_with_apocrine_metaplasia: + common: + description: >- + An invasive adenocarcinoma characterized by focal or extensive transformation + of the malignant glandular cells to cells with abundant, usually granular eosinophilic + cytoplasm. + termDef: + term: >- + Adenocarcinoma with Apocrine Metaplasia + source: NCIt + cde_id: C4202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4202" + term_id: C4202 + term_version: 20.05a + +carcinoma_with_chondroid_differentiation: + common: + description: >- + An invasive carcinoma of the breast showing differentiation towards cartilaginous + structures. + termDef: + term: >- + Breast Carcinoma with Chondroid Metaplasia + source: NCIt + cde_id: C47847 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47847" + term_id: C47847 + term_version: 20.05a + +carcinoma_with_neuroendocrine_differentiation: + common: + description: >- + An invasive adenocarcinoma characterized by the presence of focal or extensive + neurosecretory cell differentiation with the formation of organoid patterns. + termDef: + term: >- + Adenocarcinoma with Neuroendocrine Differentiation + source: NCIt + cde_id: C66745 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66745" + term_id: C66745 + term_version: 20.05a + +carcinoma_with_osseous_differentiation: + common: + description: >- + An invasive breast carcinoma showing differentiation towards bone structures. + termDef: + term: >- + Breast Carcinoma with Osseous Metaplasia + source: NCIt + cde_id: C47848 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47848" + term_id: C47848 + term_version: 20.05a + +carcinoma_with_productive_fibrosis: + common: + description: >- + An infiltrating adenocarcinoma characterized by the presence of desmoplastic + stromal reaction. + termDef: + term: >- + Scirrhous Adenocarcinoma + source: NCIt + cde_id: C2928 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2928" + term_id: C2928 + term_version: 20.05a + +carcinomatosis: + common: + description: >- + Carcinoma that has spread diffusely to an anatomic site or throughout the body. + termDef: + term: >- + Carcinomatosis + source: NCIt + cde_id: C3693 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3693" + term_id: C3693 + term_version: 20.05a + +carcinosarcoma_nos: + common: + description: >- + A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. + termDef: + term: >- + Carcinosarcoma + source: NCIt + cde_id: C34448 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C34448" + term_id: C34448 + term_version: 20.05a + +card11: + common: + description: >- + This gene plays a role in apoptotic regulation. + termDef: + term: >- + CARD11 Gene + source: NCIt + cde_id: C60668 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C60668" + term_id: C60668 + term_version: 20.10d + +cardia_nos: + common: + description: >- + The area around the esophagogastric mucosal junction where the esophageal mucosa + transitions into the gastric mucosa. + termDef: + term: >- + Gastric Cardia + source: NCIt + cde_id: C12256 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12256" + term_id: C12256 + term_version: 20.05a + +cardiovascular_disorder_nos: + common: + description: >- + A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, + veins and lymph vessels). Representative examples of non-neoplastic cardiovascular + disorders are endocarditis and hypertension. Representative examples of neoplastic + cardiovascular disorders are endocardial myxoma and angiosarcoma. + termDef: + term: >- + Cardiovascular Disorder + source: NCIt + cde_id: C2931 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2931" + term_id: C2931 + term_version: 19.12e + +carotid_body: + common: + description: >- + A cluster of cells that function as chemo-receptors, located at the bifurcation + of the carotid artery. Its main purpose is to detect changes in the composition + of arterial blood. + termDef: + term: >- + Carotid Body + source: NCIt + cde_id: C66852 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66852" + term_id: C66852 + term_version: 20.05a + +carotid_body_paraganglioma: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma arising from + paraganglia adjacent to or in the bifurcation of the common carotid artery. Most + patients present with a slow growing, painless mass in the neck. + termDef: + term: >- + Carotid Body Paraganglioma + source: NCIt + cde_id: C2932 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2932" + term_id: C2932 + term_version: 20.05a + +carotid_body_tumor: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma arising from + paraganglia adjacent to or in the bifurcation of the common carotid artery. Most + patients present with a slow growing, painless mass in the neck. + termDef: + term: >- + Carotid Body Paraganglioma + source: NCIt + cde_id: C2932 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2932" + term_id: C2932 + term_version: 20.05a + +cars: + common: + description: >- + This gene is involved in transfer RNA metabolism. + termDef: + term: >- + CARS Gene + source: NCIt + cde_id: C97369 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97369" + term_id: C97369 + term_version: 20.10d + +cartilaginous_exostosis: + common: + description: >- + A common, benign cartiliginous neoplasm arising from the metaphysis of bone. + The tumor grows on the surface of the bone; it may be pedunculated or sessile. + It is characterized by the presence of chondrocytes, a cartilage cap, and a + fibrous perichondrium that extends to the periosteum of the bone. In some cases, + there is deletion of 8q24.1 chromosome locus. + termDef: + term: >- + Osteochondroma + source: NCIt + cde_id: C3295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3295" + term_id: C3295 + term_version: 20.05a + +casp8: + common: + description: >- + This gene is involved in apoptosis, immune cell homeostasis, lymphocyte activation + and immunoprotection. + termDef: + term: >- + CASP8 Gene + source: NCIt + cde_id: C26623 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26623" + term_id: C26623 + term_version: 20.10d + +castle: + common: + description: >- + A rare primary carcinoma of the thyroid gland, composed of groups of carcinoma + cells with thymic epithelial differentiation. + termDef: + term: >- + Intrathyroid Thymic Carcinoma + source: NCIt + cde_id: C46106 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46106" + term_id: C46106 + term_version: 20.05a + +cationic_peptide_cream_cypep1: + common: + description: >- + A topical cream containing Cypep-1, a cationic lytic peptide of 27 amino acids, + with potential antineoplastic activity. Upon topical administration, Cypep-1 + selectively targets tumor cells with negatively charged cell membranes and ruptures + the cell membranes. This leads to tumor cell lysis and the release of neoantigens + into the tumor microenvironment (TME) and circulation. This elicits a specific + and potent cytotoxic T-lymphocyte (CTL) response against tumor cells expressing + these neoantigens. Warts are benign skin tumors caused by human papilloma virus + (HPV). + termDef: + term: >- + Cationic Peptide Cream Cypep-1 + source: NCIt + cde_id: C171374 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171374" + term_id: C171374 + term_version: 20.10d + +cauda_equina: + common: + description: >- + The collection of spinal nerve roots, arising from lumbar pairs two through + five, sacral pairs one through five, and the coccygeal nerve, that branch off + the conus medularis at the termination of the spinal cord, and float freely + within the lumbar cistern before exiting the spinal column at the appropriate + vertebra. + termDef: + term: >- + Cauda Equina + source: NCIt + cde_id: C12689 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12689" + term_id: C12689 + term_version: 20.05a + +cavernous_hemangioma: + common: + description: >- + A hemangioma characterized by the presence of cavernous vascular spaces. + termDef: + term: >- + Cavernous Hemangioma + source: NCIt + cde_id: C3086 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3086" + term_id: C3086 + term_version: 20.05a + +cavernous_lymphangioma: + common: + description: >- + A lymphangioma characterized by the presence of thin-walled cavernous lymphatic + spaces. + termDef: + term: >- + Cavernous Lymphangioma + source: NCIt + cde_id: C53316 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53316" + term_id: C53316 + term_version: 20.05a + +cayman_islands: + common: + description: >- + An island group in the Caribbean Sea, south of Cuba and west of Jamaica. + termDef: + term: >- + Cayman Islands + source: NCIt + cde_id: C16391 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16391" + term_id: C16391 + term_version: 19.12e + +cbfa2t3: + common: + description: >- + This gene plays a role in transcriptional regulation. + termDef: + term: >- + CBFA2T3 Gene + source: NCIt + cde_id: C97445 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97445" + term_id: C97445 + term_version: 20.10d + +cbfb: + common: + description: >- + This gene is involved in hematopoiesis and osteogenesis. + termDef: + term: >- + CBFB Gene + source: NCIt + cde_id: C18584 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18584" + term_id: C18584 + term_version: 20.10d + +cbl: + common: + description: >- + This gene plays a role in signal transduction and the regulation of protein + degradation. + termDef: + term: >- + CBL Gene + source: NCIt + cde_id: C18364 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18364" + term_id: C18364 + term_version: 20.10d + +cblb: + common: + description: >- + This gene plays a role in the regulation of T cell activation. + termDef: + term: >- + CBLB Gene + source: NCIt + cde_id: C21589 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21589" + term_id: C21589 + term_version: 20.10d + +cblc: + common: + description: >- + This gene is involved in both ubiquitination and signaling. + termDef: + term: >- + CBLC Gene + source: NCIt + cde_id: C97439 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97439" + term_id: C97439 + term_version: 20.10d + +ccdc6: + common: + description: >- + This gene may play a role in tumor suppression. + termDef: + term: >- + CCDC6 Gene + source: NCIt + cde_id: C18376 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18376" + term_id: C18376 + term_version: 20.10d + +ccnb1ip1: + common: + description: >- + This gene plays a role in both ubiquitination and cell cycle progression. + termDef: + term: >- + CCNB1IP1 Gene + source: NCIt + cde_id: C97372 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97372" + term_id: C97372 + term_version: 20.10d + +ccnc: + common: + description: >- + This gene plays a role in the modulation of gene transcription. + termDef: + term: >- + CCNC Gene + source: NCIt + cde_id: C105393 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C105393" + term_id: C105393 + term_version: 20.10d + +ccnd1: + common: + description: >- + This gene plays a role in the regulation of mitotic events. + termDef: + term: >- + G1/S-Specific Cyclin-D1 + source: NCIt + cde_id: C18021 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18021" + term_id: C18021 + term_version: 20.10d + +ccnd2: + common: + description: >- + This gene is involved in the regulation of the G1/S phase of the cell cycle. + termDef: + term: >- + CCND2 Gene + source: NCIt + cde_id: C39596 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39596" + term_id: C39596 + term_version: 20.10d + +ccnd3: + common: + description: >- + This gene is involved in cell cycle progression. + termDef: + term: >- + CCND3 Gene + source: NCIt + cde_id: C97381 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97381" + term_id: C97381 + term_version: 20.10d + +ccne1: + common: + description: >- + This gene regulates the G1/S phase of the cell cycle by cyclin expression. + termDef: + term: >- + CCNE1 Gene + source: NCIt + cde_id: C21412 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21412" + term_id: C21412 + term_version: 20.10d + +ccr4: + common: + description: >- + This gene is involved in chemokine-dependent G protein-coupled receptor signaling. + termDef: + term: >- + CCR4 Gene + source: NCIt + cde_id: C129065 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129065" + term_id: C129065 + term_version: 20.10d + +ccr7: + common: + description: >- + This gene plays a role in immune function. + termDef: + term: >- + CCR7 Gene + source: NCIt + cde_id: C104128 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104128" + term_id: C104128 + term_version: 20.10d + +cd10: + common: + description: >- + Neprilysin (750 aa, ~86 kDa) is encoded by the human MME gene. This protein + is involved in the metabolism of biologically active peptides. + termDef: + term: >- + Neprilysin + source: NCIt + cde_id: C16836 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16836" + term_id: C16836 + term_version: 20.10d + +cd117: + common: + description: >- + Mast/stem cell growth factor receptor Kit (976 aa, ~110 kDa) is encoded by the + human KIT gene. This protein is involved in cell survival, tyrosine phosphorylation + and ligand-mediated signaling. + termDef: + term: >- + Mast/Stem Cell Growth Factor Receptor Kit + source: NCIt + cde_id: C17328 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17328" + term_id: C17328 + term_version: 20.10d + +cd11b_agonist_gb1275: + common: + description: >- + An orally bioavailable small molecule agonist of CD11b (integrin alpha-M; ITGAM; + integrin alpha M chain), with potential immunomodulating activity. Upon administration, + CD11b agonist GB1275 targets and binds to CD11b, thereby activating CD11b. This + leads to CD11b-mediated signaling and promotes pro-inflammatory macrophage polarization + while suppressing immunosuppressive macrophage polarization. This reduces influx + of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells + (MDSCs) in the tumor microenvironment (TME), promotes anti-tumor immune responses, + induces cytotoxic T-lymphocytes (CTLs) and suppresses tumor growth. CD11b, a + member of the integrin family of cell adhesion receptors highly expressed on + immune system cells, is a negative regulator of immune suppression and activates + anti-tumor innate immunity. + termDef: + term: >- + CD11b Agonist GB1275 + source: NCIt + cde_id: C165605 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165605" + term_id: C165605 + term_version: 20.10d + +cd123cd33_compound_car_t_cells: + common: + description: >- + A preparation of T-lymphocytes transduced with a lentiviral vector expressing + a compound chimeric antigen receptor (cCAR) containing two distinct units of + CARs, one specific for the CD123 (interleukin-3 receptor alpha chain or IL3RA) + antigen and one specific for the CD33 antigen, with potential immunomodulating + and antineoplastic activities. Upon administration, the CD123-CD33 cCAR T cells + specifically and simultaneously target and bind to tumor cells expressing CD123 + and/or CD33. This induces selective toxicity in tumor cells that express the + CD123 antigen and/or the CD33 antigen. CD123 is normally expressed on committed + blood progenitor cells in the bone marrow; its overexpression is associated + with increased leukemic cell proliferation and aggressiveness. CD33 is expressed + on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid + leukemia cells. Targeting two different antigens may improve coverage and protect + against antigen escape and relapse as it is less likely for tumor cells to lose + both antigens. Additionally, the CD123-CD33 cCAR T cells express CD52 on the + cell surface. This allows the depletion of the CD123-CD33 cCAR T cells with + the administration of the anti-CD52 monoclonal antibody alemtuzumab, in case + of unacceptable side effects. + termDef: + term: >- + CD123-CD33 Compound CAR T Cells + source: NCIt + cde_id: C173970 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173970" + term_id: C173970 + term_version: 20.10d + +cd123specific_targeting_module_tm123: + common: + description: >- + A preparation of soluble adapter molecules consisting of an antigen-binding + moiety targeting CD123 linked to a peptide motif recognizable by UniCAR02-T, + that may be used to activate UniCAR02-T. Upon administration of CD123-specific + targeting module (TM) TM123, and upon co-administration of UniCAR02-T, the antigen-binding + moiety of TM123 targets and binds to cancer cells expressing CD123, and the + binding domain of UniCAR02-T binds to the nuclear antigen motif of TM123. This + activates UniCAR02-T, and induces selective toxicity in and causes lysis of + CD123-expressing tumor cells. CD123 is normally expressed on committed blood + progenitor cells in the bone marrow; its overexpression is associated with both + increased leukemic cell proliferation and aggressiveness. + termDef: + term: >- + CD123-specific Targeting Module TM123 + source: NCIt + cde_id: C175461 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175461" + term_id: C175461 + term_version: 20.10d + +cd138: + common: + description: >- + Syndecan-1 (310 aa, ~32 kDa) is encoded by the human SDC1 gene. This protein + is involved in the mediation of cell adhesion, signaling and cytoskeletal organization. + termDef: + term: >- + Syndecan-1 + source: NCIt + cde_id: C96914 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96914" + term_id: C96914 + term_version: 20.10d + +cd14: + common: + description: >- + Monocyte differentiation antigen CD14 (375 aa, ~40 kDa) is encoded by the human + CD14 gene. This protein plays a role in the innate immune response to lipopolysaccharide + exposure. + termDef: + term: >- + Monocyte Differentiation Antigen CD14 + source: NCIt + cde_id: C17488 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17488" + term_id: C17488 + term_version: 20.10d + +cd15: + common: + description: >- + A carbohydrate molecule found on the surface of neutrophils, eosinophils and + monocytes. It is involved in neutrophil chemotaxis and phagocytosis. Expression + of this antigen is associated with Hodgkin disease, chronic lymphocytic leukemia, + and acute lymphoblastic leukemia. + termDef: + term: >- + CD15 Antigen + source: NCIt + cde_id: C96898 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96898" + term_id: C96898 + term_version: 20.10d + +cd19: + common: + description: >- + B-lymphocyte antigen CD19 (556 aa, ~61 kDa) is encoded by the human CD19 gene. + This protein is involved in enhancing B-cell receptor-dependent signaling. + termDef: + term: >- + B-Lymphocyte Antigen CD19 + source: NCIt + cde_id: C38894 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38894" + term_id: C38894 + term_version: 20.10d + +cd20: + common: + description: >- + B-lymphocyte antigen CD20 (297 aa, ~33 kDa) is encoded by the human MS4A1 gene. + This protein plays a role in both the activation and proliferation of B-cells. + termDef: + term: >- + B-Lymphocyte Antigen CD20 + source: NCIt + cde_id: C38896 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38896" + term_id: C38896 + term_version: 20.10d + +cd209: + common: + description: >- + This gene plays a role in the regulation of host defense responses and mediates + pathogen-binding properties. + termDef: + term: >- + CD209 Gene + source: NCIt + cde_id: C21568 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21568" + term_id: C21568 + term_version: 20.10d + +cd20cd19_compound_car_t_cells: + common: + description: >- + A preparation of T-lymphocytes transduced with a lentiviral vector expressing + a compound chimeric antigen receptor (cCAR) containing two distinct units of + CARs, one specific for the tumor-associated antigen (TAA) cluster of differentiation + 20 (CD20) and one specific for the TAA CD19, with potential immunomodulating + and antineoplastic activities. Upon administration, the CD20-CD19 cCAR T cells + specifically and simultaneously target and bind to tumor cells expressing CD20 + and/or CD19. This induces selective toxicity in tumor cells that express CD20 + and/or CD19. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed + in B-cell lineage malignancies. Targeting two different antigens may improve + coverage and protect against antigen escape and relapse as it is less likely + for tumor cells to lose both antigens. + termDef: + term: >- + CD20-CD19 Compound CAR T Cells + source: NCIt + cde_id: C173960 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173960" + term_id: C173960 + term_version: 20.10d + +cd22: + common: + description: >- + B-cell receptor CD22 (847 aa, ~95 kDa) is encoded by the human CD22 gene. This + protein is involved in B-cell/B-cell interactions and downstream signaling. + termDef: + term: >- + B-Cell Receptor CD22 + source: NCIt + cde_id: C17279 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17279" + term_id: C17279 + term_version: 20.10d + +cd23: + common: + description: >- + Low affinity immunoglobulin epsilon Fc receptor (321 aa, ~36 kDa) is encoded + by the human FCER2 gene. This protein is involved in B cell differentiation + and IgE production. + termDef: + term: >- + Low Affinity Immunoglobulin Epsilon Fc Receptor + source: NCIt + cde_id: C96902 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96902" + term_id: C96902 + term_version: 20.10d + +cd25: + common: + description: >- + Interleukin-2 receptor subunit alpha (272 aa, ~31 kDa) is encoded by the human + IL2RA gene. This protein plays a role in interleukin-2-dependent signaling. + termDef: + term: >- + Interleukin-2 Receptor Subunit Alpha + source: NCIt + cde_id: C17073 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17073" + term_id: C17073 + term_version: 20.10d + +cd274: + common: + description: >- + This gene is involved in T cell activation and proliferation. + termDef: + term: >- + CD274 Gene + source: NCIt + cde_id: C96022 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96022" + term_id: C96022 + term_version: 20.10d + +cd28: + common: + description: >- + This gene plays several roles in cellular functions specific to the T-cell. + termDef: + term: >- + CD28 Gene + source: NCIt + cde_id: C21291 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21291" + term_id: C21291 + term_version: 20.10d + +cd28icos_antagonist_alpn101: + common: + description: >- + An Fc fusion protein comprised of a human inducible T-cell costimulator ligand + (ICOSL) variant immunoglobulin domain (vIgD) that binds to both inducible T-cell + costimulator (ICOS; CD278) and cluster of differentiation 28 (CD28), with potential + immunomodulating activity. Upon administration, CD28/ICOS antagonist ALPN-101 + targets and binds to both CD28 and ICOS expressed on certain T-cells. This prevents + the activation of CD28 and ICOS by its ligands, thereby blocking the two T-cell + costimulatory pathways and the resulting T-cell activation. CD28 is involved + in initiation of the pathogenic process in graft versus host disease (GVHD). + Following initial activation, CD28 is often downregulated while ICOS is upregulated, + possibly sustaining GVHD. Dual blockade of CD28 and ICOS may be superior to + individual blockade of CD28 or ICOS alone. + termDef: + term: >- + CD28/ICOS Antagonist ALPN-101 + source: NCIt + cde_id: C168584 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168584" + term_id: C168584 + term_version: 20.10d + +cd3: + common: + description: >- + Consisting of cell surface type I membrane Delta, Epsilon, Gamma, Zeta, and + Eta protein subunits with ITAM domains and noncovalently associated with the + disulfide bound heterodimeric alpha/beta and gamma/delta TCR, the CD3 complex + couples receptor antigen recognition to signal transduction pathways during + T-cell activation. During TCR engagement with MHC-associated antigen on host + cell surfaces and synapse formation, CD3 activity leads to Tyr-phosphorylated + CD3 subunits, Tyr phosphorylation of LAT colocalized in lipid rafts, and MAPK + activation. CD3 signal transduction appears to involve LCK, ZAP70, Nck, SLA, + SLA2, and DOCK2. CD3 subunits may also associate with the cytoskeleton. CD3 + also mediates TCR signal transduction during the developmental transition through + positive selection of immature thymocytes to mature CD4+ or CD8+ T cells. (NCI) + termDef: + term: >- + CD3 Complex + source: NCIt + cde_id: C38897 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38897" + term_id: C38897 + term_version: 20.10d + +cd30: + common: + description: >- + Tumor necrosis factor receptor superfamily member 8 (595 aa, ~ 64 kDa) is encoded + by the human TNFRSF8 gene. This protein is involved in ligand-mediated signal + transduction, the positive regulation of apoptosis and the inhibition of cell + proliferation. + termDef: + term: >- + Tumor Necrosis Factor Receptor Superfamily Member 8 + source: NCIt + cde_id: C38906 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38906" + term_id: C38906 + term_version: 20.10d + +cd33: + common: + description: >- + Myeloid cell surface antigen CD33 (364 aa, ~40 kDa) is encoded by the human + CD33 gene. This protein is involved in the mediation of cell adhesion and the + regulation of cell-cell signaling. + termDef: + term: >- + Myeloid Cell Surface Antigen CD33 + source: NCIt + cde_id: C97246 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97246" + term_id: C97246 + term_version: 20.10d + +cd34: + common: + description: >- + Hematopoietic progenitor cell antigen CD34 (385 aa, ~41 kDa) is encoded by the + human CD34 gene. This protein plays a role in cell-cell adhesion and may have + a role in leukocyte migration. + termDef: + term: >- + Hematopoietic Progenitor Cell Antigen CD34 + source: NCIt + cde_id: C17280 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17280" + term_id: C17280 + term_version: 20.10d + +cd44v6specific_car_tcells: + common: + description: >- + A preparation of genetically modified T-lymphocytes transduced with a lentiviral + vector encoding a fourth-generation specific chimeric antigen receptor (4SCAR) + specific for CD44 variant domain 6 (CD44v6), with potential immunomodulating + and antineoplastic activities. Upon administration, CD44v6-specific CAR T-cells + specifically recognize and kill CD44v6-expressing tumor cells. CD44, a transmembrane + glycoprotein and hyaluronic acid receptor, is expressed in healthy tissue and + overexpressed in numerous cancer cell types. CD44v6, the isoform containing + the variant domain 6 of CD44 gene, plays a key role in tumor cell invasion, + proliferation and metastasis. + termDef: + term: >- + CD44v6-specific CAR T-cells + source: NCIt + cde_id: C173368 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173368" + term_id: C173368 + term_version: 20.10d + +cd45: + common: + description: >- + Receptor-type tyrosine-protein phosphatase C (1304 aa, ~147 kDa) is encoded + by the human PTPRC gene. This protein plays a role in protein dephosphorylation. + termDef: + term: >- + Receptor-Type Tyrosine-Protein Phosphatase C + source: NCIt + cde_id: C17282 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17282" + term_id: C17282 + term_version: 20.10d + +cd5: + common: + description: >- + T-cell surface glycoprotein CD5 (495 aa, ~54 kDa) is encoded by the human CD5 + gene. This protein may be involved in regulating the proliferation of T-cells. + termDef: + term: >- + T-Cell Surface Glycoprotein CD5 + source: NCIt + cde_id: C73124 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73124" + term_id: C73124 + term_version: 20.10d + +cd56: + common: + description: >- + Cell adhesion molecule involved in a diverse range of contact-mediated interactions + among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but + transiently expressed in many tissues early in embryogenesis. Four main isoforms + exist, including CD56 (ANTIGENS, CD56), but there are many other variants resulting + from alternative splicing and post-translational modifications. (From Pigott + & Power, The Adhesion Molecule FactsBook, 1993, pp115-119) + termDef: + term: >- + Neural Cell Adhesion Molecule 1 + source: NCIt + cde_id: C17891 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17891" + term_id: C17891 + term_version: 20.10d + +cd7: + common: + description: >- + T-cell antigen CD7 (240 aa, ~25 kDa) is encoded by the human CD7 gene. This + protein plays a role in the development and function of lymphoid cells. + termDef: + term: >- + T-Cell Antigen CD7 + source: NCIt + cde_id: C38935 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38935" + term_id: C38935 + term_version: 20.10d + +cd73_inhibitor_ab680: + common: + description: >- + A small molecule, competitive inhibitor of the ectoenzyme CD73 (cluster of differentiation + 73; 5'-ecto-nucleotidase; 5'-NT; ecto-5'-nucleotidase), with potential immunomodulating + and antineoplastic activities. Upon administration, CD73 Inhibitor AB680 targets + and binds to CD73, leading to clustering of and internalization of CD73. This + prevents CD73-mediated conversion of adenosine monophosphate (AMP) to adenosine + and decreases the amount of free adenosine in the tumor microenvironment (TME). + This prevents adenosine-mediated lymphocyte suppression and increases the activity + of CD8-positive effector cells and natural killer (NK) cells. This also activates + macrophages and reduces the activity of myeloid-derived suppressor cells (MDSCs) + and regulatory T-lymphocytes (Tregs). By abrogating the inhibitory effect on + the immune system and enhancing the cytotoxic T-cell-mediated immune response + against cancer cells, tumor cell growth decreases. In addition, clustering and + internalization of CD73 decreases the migration of cancer cells and prevents + metastasis. CD73, a plasma membrane protein belonging to the 5'-nucleotidase + (NTase) family, upregulated on a number of cancer cell types, catalyzes the + conversion of extracellular nucleotides, such as AMP, to membrane-permeable + nucleosides, such as adenosine; it plays a key role in adenosine-mediated immunosuppression + within the TME. + termDef: + term: >- + CD73 Inhibitor AB680 + source: NCIt + cde_id: C167156 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167156" + term_id: C167156 + term_version: 20.10d + +cd73_inhibitor_ly3475070: + common: + description: >- + An orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation + 73; 5'-ecto-nucleotidase; 5'-NT; ecto-5'-nucleotidase), with potential immunomodulating + and antineoplastic activities. Upon oral administration, CD73 inhibitor LY3475070 + targets and binds to CD73, leading to clustering of and internalization of CD73. + This prevents CD73-mediated conversion of adenosine monophosphate (AMP) to adenosine + and decreases the amount of free adenosine in the tumor microenvironment (TME). + This prevents adenosine-mediated lymphocyte suppression and increases the activity + of CD8-positive effector cells and natural killer (NK) cells. This also activates + macrophages and reduces the activity of myeloid-derived suppressor cells (MDSCs) + and regulatory T-lymphocytes (Tregs). By abrogating the inhibitory effect on + the immune system and enhancing the cytotoxic T-cell-mediated immune response + against tumor cells, tumor cell growth decreases. In addition, clustering and + internalization of CD73 decreases the migration of cancer cells and prevents + metastasis. CD73, a plasma membrane protein belonging to the 5'-nucleotidase + (NTase) family, catalyzes the conversion of extracellular nucleotides, such + as AMP, to membrane-permeable nucleosides, such as adenosine. It is upregulated + in a number of cancer cell types and plays a key role in adenosine-mediated + immunosuppression within the TME. + termDef: + term: >- + CD73 Inhibitor LY3475070 + source: NCIt + cde_id: C170952 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170952" + term_id: C170952 + term_version: 20.10d + +cd74: + common: + description: >- + This gene plays a role in antigen processing and presentation. + termDef: + term: >- + CD74 Gene + source: NCIt + cde_id: C97418 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97418" + term_id: C97418 + term_version: 20.10d + +cd79a: + common: + description: >- + This gene is involved in B-cell signaling and proliferation. + termDef: + term: >- + B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain + source: NCIt + cde_id: C97421 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97421" + term_id: C97421 + term_version: 20.10d + +cd79b: + common: + description: >- + This gene plays a role in signaling in B-cells. + termDef: + term: >- + CD79B Gene + source: NCIt + cde_id: C97424 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97424" + term_id: C97424 + term_version: 20.10d + +cd80fc_fusion_protein_alpn202: + common: + description: >- + A fusion protein composed of the N-terminal Ig variable-like (IgV) domain of + CD80 fused to a human immunoglobulin G1 (IgG1) Fc fragment, with potential immunostimulatory, + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + CD80-Fc fusion protein ALPN-202 targets and binds to programmed cell death-1 + ligand 1 (PD-L1; cluster of differentiation 274; CD274) expressed on tumor cells, + which blocks its binding to and activation of its receptor programmed cell death + 1 (PD-1; cluster of differentiation 279; CD279), and leads to PD-L1-dependent + CD28 binding and co-stimulation in the local tumor microenvironment (TME). This + reverses T-cell inactivation caused by PD-1/PD-L1 signaling, leads to the co-stimulation + of T-cell responses including the activation of naive and memory T-cells in + the TME and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune + response against PD-L1-expressing tumor cells. In addition, ALPN-202 targets + and binds to CTL-associated antigen 4 (CTLA4; CTLA-4) expressed on T-cells. + This prevents the binding of CTLA-4 to endogenous CD80, thereby enabling CD80-CD28 + engagement, CD28 signaling, and T-cell activation. This further promotes T-cell + activity. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding + to PD-1 on T-cells suppresses the immune system and results in immune evasion. + CD80 is a co-stimulatory molecule expressed on activated antigen presenting + cells (APCs) that plays a key role in T-cell activation upon binding to CD28 + on T-cells. On the other hand, binding of CD80 to CTLA-4 prevents CD80-CD28 + engagement, thereby inhibiting T-cell activity and immune activation. CTLA-4 + is a member of the immunoglobulin superfamily (IgSF) and an inhibitory molecule + upregulated by T-cells following T-cell activation. It plays a key role in the + downregulation of the immune system. + termDef: + term: >- + CD80-Fc Fusion Protein ALPN-202 + source: NCIt + cde_id: C174515 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174515" + term_id: C174515 + term_version: 20.10d + +cd80fc_fusion_protein_fpt155: + common: + description: >- + A recombinant fusion protein composed of the extracellular domain (ECD) of human + CD80 (B7.1) fused to a human immunoglobulin G1 (IgG1) Fc fragment, with potential + immunostimulatory, immune checkpoint inhibitory and antineoplastic activities. + Upon administration of CD80-Fc fusion protein FPT155, the CD80 moiety targets + and binds to CD28, which in the presence of antigenic T-cell receptor (TCR) + signaling, leads to the co-stimulation of T-cell responses including the activation + of naive and memory T-cells. This leads to a cytotoxic T-lymphocyte (CTL)-mediated + immune response against cancer cells, thereby killing cancer cells. FPT155 also + targets and binds to CTL-associated antigen 4 (CTLA4; CTLA-4), preventing the + binding of CTLA-4 to endogenous CD80, thereby enabling CD80-CD28 engagement, + CD28 signaling, and T-cell activation in the tumor microenvironment. CD80 is + a co-stimulatory molecule expressed on activated antigen presenting cells that + plays a key role in T-cell activation upon binding to CD28 on T-cells. On the + other hand, binding of CD80 to CTLA-4 prevents CD80-CD28 engagement, thereby + inhibiting T-cell activity and immune activation. CTLA-4 is a member of the + immunoglobulin superfamily (IgSF) and an inhibitory molecule upregulated by + T-cells following T-cell activation. It plays a key role in the downregulation + of the immune system. + termDef: + term: >- + CD80-Fc Fusion Protein FPT155 + source: NCIt + cde_id: C169063 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C169063" + term_id: C169063 + term_version: 20.10d + +cd99: + common: + description: >- + This gene plays a role in the cell adhesion process. + termDef: + term: >- + CD99 Gene + source: NCIt + cde_id: C102939 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102939" + term_id: C102939 + term_version: 20.10d + +cdc73: + common: + description: >- + This gene is involved in transcription and may play a role in cell cycle progression. + termDef: + term: >- + CDC73 Gene + source: NCIt + cde_id: C43569 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43569" + term_id: C43569 + term_version: 20.10d + +cdh1: + common: + description: >- + This gene plays a role in cell-cell adhesion and loss of function contributes + to the progression of many carcinomas. + termDef: + term: >- + CDH1 Gene + source: NCIt + cde_id: C18249 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18249" + term_id: C18249 + term_version: 20.10d + +cdh10: + common: + description: >- + This gene plays a role in the modulation of neuronal cell shape and cell-cell + adhesion. + termDef: + term: >- + CDH10 Gene + source: NCIt + cde_id: C143093 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143093" + term_id: C143093 + term_version: 20.10d + +cdh11: + common: + description: >- + This gene is involved in the adherens junction. + termDef: + term: >- + CDH11 Gene + source: NCIt + cde_id: C97427 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97427" + term_id: C97427 + term_version: 20.10d + +cdh17: + common: + description: >- + This gene is involved in cell-cell adhesion and intestinal proton-dependent + peptide transport. + termDef: + term: >- + CDH17 Gene + source: NCIt + cde_id: C143096 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143096" + term_id: C143096 + term_version: 20.10d + +cdk12: + common: + description: >- + This gene is involved in protein phosphorylation, RNA splicing and transcription + elongation. + termDef: + term: >- + CDK12 Gene + source: NCIt + cde_id: C101095 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101095" + term_id: C101095 + term_version: 20.10d + +cdk2_inhibitor_pf07104091: + common: + description: >- + An orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential + antineoplastic activity. Upon administration, CDK2 inhibitor PF-07104091 selectively + targets, binds to and inhibits the activity of CDK2. This may lead to cell cycle + arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. + CDKs are serine/threonine kinases that are important regulators of cell cycle + progression and cellular proliferation and are frequently overexpressed in tumor + cells. CDK2/cyclin E complex plays an important role in retinoblastoma (Rb) + protein phosphorylation and the G1-S phase cell cycle transition. CDK2/cyclin + A complex plays an important role in DNA synthesis in S phase and the activation + of CDK1/cyclin B for the G2-M phase cell cycle transition. + termDef: + term: >- + CDK2 Inhibitor PF-07104091 + source: NCIt + cde_id: C175251 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175251" + term_id: C175251 + term_version: 20.10d + +cdk4: + common: + description: >- + This gene is involved in G1 stage cell cycle progression. + termDef: + term: >- + CDK4 Gene + source: NCIt + cde_id: C18250 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18250" + term_id: C18250 + term_version: 20.10d + +cdk46_inhibitor_cs3002: + common: + description: >- + An orally bioavailable selective inhibitor of cyclin-dependent kinase (CDK) + types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral + administration, CDK4/6 inhibitor CS3002 selectively targets and inhibits CDK4 + and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) + early in the G1 phase, prevents CDK-mediated G1-S-phase transition and leads + to cell cycle arrest. This suppresses DNA replication and decreases tumor cell + proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated + in many tumor cell types and play a key role in the regulation of both cell + cycle progression from the G1-phase into the S-phase and tumor cell proliferation. + termDef: + term: >- + CDK4/6 Inhibitor CS3002 + source: NCIt + cde_id: C174417 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174417" + term_id: C174417 + term_version: 20.10d + +cdk46_inhibitor_hs10342: + common: + description: >- + An orally bioavailable, small molecular, selective inhibitor of cyclin-dependent + kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. + Upon oral administration, CDK4/6 inhibitor HS-10342 selectively inhibits CDK4 + and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) + early in the G1 phase, prevents CDK-mediated G1-S-phase transition and leads + to cell cycle arrest. This suppresses DNA replication and decreases tumor cell + proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated + in many tumor cell types and play a key role in the regulation of both cell + cycle progression from the G1-phase into the S-phase and tumor cell proliferation. + termDef: + term: >- + CDK4/6 Inhibitor HS-10342 + source: NCIt + cde_id: C170749 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170749" + term_id: C170749 + term_version: 20.10d + +cdk46_inhibitor_tqb3616: + common: + description: >- + An orally bioavailable, selective inhibitor of cyclin-dependent kinase (CDK) + types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral + administration, CDK4/6 inhibitor TQB3616 selectively inhibits CDK4 and CDK6, + which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the + G1 phase, prevents CDK-mediated G1-S-phase transition and leads to cell cycle + arrest. This suppresses DNA replication and decreases tumor cell proliferation. + CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell + types and play a key role in the regulation of both cell cycle progression from + the G1-phase into the S-phase and tumor cell proliferation. + termDef: + term: >- + CDK4/6 Inhibitor TQB3616 + source: NCIt + cde_id: C171344 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171344" + term_id: C171344 + term_version: 20.10d + +cdk6: + common: + description: >- + This gene plays a role in the progression of the cell cycle. + termDef: + term: >- + CDK6 Gene + source: NCIt + cde_id: C97384 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97384" + term_id: C97384 + term_version: 20.10d + +cdk7_inhibitor_sy5609: + common: + description: >- + An orally bioavailable, selective inhibitor of cyclin-dependent kinase 7 (CDK7), + with potential antineoplastic activity. Upon oral administration, SY-5609 selectively + targets, binds to and inhibits the activity of CDK7, thereby inhibiting CDK7-mediated + signaling. Specifically, inhibition of CDK7 prevents phosphorylation of the + carboxy-terminal domain (CTD) of RNA Polymerase II, thereby preventing transcription + of important cancer-promoting genes. In addition, it prevents phosphorylation + of the cell cycle kinases CDK1, 2, 4, and 6, thereby disrupting uncontrolled + cell cycle progression. Altogether, this may induce apoptosis, cause cell cycle + arrest, inhibit DNA damage repair and inhibit tumor cell proliferation in certain + cancers that are dependent on CDK7-mediated transcriptional regulation and signaling. + CDK7, a serine/threonine kinase, plays a role in controlling cell cycle progression, + transcriptional regulation, and promotes the expression of key oncogenes such + as c-Myc and beta-catenin, through the phosphorylation of RNA polymerase II. + termDef: + term: >- + CDK7 Inhibitor SY-5609 + source: NCIt + cde_id: C172390 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172390" + term_id: C172390 + term_version: 20.10d + +cdk819_inhibitor_sel_120: + common: + description: >- + An orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), + with potential antineoplastic and chemoprotective activities. Upon oral administration, + CDK8/19 inhibitor SEL 120 targets, binds to and inhibits the activity of CDK8/19, + which prevents activation of CDK8/19-mediated oncogenic signaling pathways, + blocks selective transcription of various tumor-promoting genes, and inhibits + proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine + kinases involved in the regulation of the cell cycle, are overexpressed in certain + cancer cell types and play key roles in tumor cell proliferation. + termDef: + term: >- + CDK8/19 Inhibitor SEL 120 + source: NCIt + cde_id: C165747 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165747" + term_id: C165747 + term_version: 20.10d + +cdkn1a: + common: + description: >- + This gene is a regulator of cell cycle progression at the G1 phase of the cell + cycle. + termDef: + term: >- + CDKN1A Gene + source: NCIt + cde_id: C17782 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17782" + term_id: C17782 + term_version: 20.10d + +cdkn1b: + common: + description: >- + This gene is involved in cell cycle regulation and cyclin regulation. + termDef: + term: >- + CDKN1B Gene + source: NCIt + cde_id: C20060 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20060" + term_id: C20060 + term_version: 20.10d + +cdkn2a: + common: + description: >- + This gene functions as a tumor suppressor and transcriptional regulator. + termDef: + term: >- + CDKN2A Gene + source: NCIt + cde_id: C18022 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18022" + term_id: C18022 + term_version: 20.10d + +cdkn2c: + common: + description: >- + This gene is involved in cell cycle inhibition and regulation. + termDef: + term: >- + CDKN2C Gene + source: NCIt + cde_id: C24288 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24288" + term_id: C24288 + term_version: 20.10d + +cdx2: + common: + description: >- + This gene plays a role in transcriptional initiation, embryonic axial elongation + and patterning. + termDef: + term: >- + CDX2 Gene + source: NCIt + cde_id: C24292 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24292" + term_id: C24292 + term_version: 20.10d + +cea: + common: + description: >- + A cancer-specific antigen associated with both tumors and the developing fetus. + The main use of this antigen is as a tumor marker, especially with respect to + intestinal cancers. Production of the antigen ceases shortly before birth, but + may reappear in people who develop certain types of cancer. + termDef: + term: >- + Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 + source: NCIt + cde_id: C25159 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25159" + term_id: C25159 + term_version: 20.10d + +cebp_beta_antagonist_st101: + common: + description: >- + A peptide antagonist of the transcription factor CCAAT/enhancer-binding protein + beta (C/EBP beta), with potential antineoplastic activity. Upon administration, + C/EBP beta antagonist ST101 targets and inhibits the activity of C/EBP beta. + This prevents the expression of C/EBP beta target genes and proteins, including + the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), cyclins and inhibitor + of differentiation (ID) family of proteins, which are involved in cell proliferation, + differentiation, and cell cycle regulation. This may lead to apoptosis in tumor + cells. C/EBP beta is overexpressed in many cancers and plays an important role + in the regulation of cell differentiation; its expression is associated with + tumor cell survival and proliferation. + termDef: + term: >- + C/EBP Beta Antagonist ST101 + source: NCIt + cde_id: C174169 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174169" + term_id: C174169 + term_version: 20.10d + +cebpa: + common: + description: >- + This gene plays a role in body weight homeostasis and cellular proliferation. + Mutations in the gene are associated with acute myeloid leukemia. + termDef: + term: >- + CEBPA Gene + source: NCIt + cde_id: C39598 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39598" + term_id: C39598 + term_version: 20.10d + +cecum: + common: + description: >- + A blind pouch-like commencement of the colon in the right lower quadrant of + the abdomen at the end of the small intestine and the start of the large intestine. + termDef: + term: >- + Cecum + source: NCIt + cde_id: C12381 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12381" + term_id: C12381 + term_version: 20.05a + +cedazuridineazacitidine_combination_agent_astx030: + common: + description: >- + An orally available fixed-dose combination agent containing cedazuridine, a + cytidine deaminase (CDA) inhibitor, and the cytidine antimetabolite azacitidine, + with potential antineoplastic activity. Upon oral administration of the cedazuridine/azacitidine + combination agent ASTX030, cedazuridine binds to and inhibits CDA, an enzyme + primarily found in the gastrointestinal (GI) tract and liver that catalyzes + the deamination of cytidine and cytidine analogs. This prevents the breakdown + of azacitidine, increases its bioavailability and efficacy while decreasing + GI toxicity due to the administration of lower doses of azacitidine. Azacitidine + exerts its antineoplastic activity through the incorporation of its triphosphate + form into DNA, which inhibits DNA methyltransferase (DNMT), thereby blocking + DNA methylation and results in hypomethylation of DNA. This interferes with + DNA replication and decreases tumor cell growth. + termDef: + term: >- + Cedazuridine/Azacitidine Combination Agent ASTX030 + source: NCIt + cde_id: C171649 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171649" + term_id: C171649 + term_version: 20.10d + +cellular_angiofibroma: + common: + description: >- + A benign mesenchymal neoplasm that usually arises in the superficial soft tissues + of the vulva or inguinal and scrotal regions. It is characterized by the presence + of a cellular fibroblastic proliferation in an edematous to fibrous stroma containing + numerous vessels. + termDef: + term: >- + Cellular Angiofibroma + source: NCIt + cde_id: C27257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27257" + term_id: C27257 + term_version: 20.05a + +cellular_blue_nevus: + common: + description: >- + A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell + architecture occupying the reticular dermis. The cellular infiltrate often extends + into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped + melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped + melanocytes. In occasional cases an increased mitotic activity, focal necrosis, + and nuclear pleomorphism may be seen. Such cases with atypical features may + have an uncertain malignant potential. + termDef: + term: >- + Cellular Blue Nevus + source: NCIt + cde_id: C4241 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4241" + term_id: C4241 + term_version: 20.05a + +cellular_ependymoma: + common: + description: >- + An ependymoma which shows conspicuous cellularity without a significant increase + in mitotic rate. (Adapted from WHO) + termDef: + term: >- + Cellular Ependymoma + source: NCIt + cde_id: C4713 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4713" + term_id: C4713 + term_version: 20.05a + +cellular_fibroma: + common: + description: >- + A morphologic variant of fibroma characterized by increased cellularity. + termDef: + term: >- + Cellular Fibroma + source: NCIt + cde_id: C6892 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6892" + term_id: C6892 + term_version: 20.05a + +cellular_leiomyoma: + common: + description: >- + A morphologic variant of classic leiomyoma characterized by a dense cellular + infiltrate composed of spindle or round cells with scant cytoplasm and a less + obvious interlacing fascicle pattern. + termDef: + term: >- + Cellular Leiomyoma + source: NCIt + cde_id: C4256 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4256" + term_id: C4256 + term_version: 20.05a + +cellular_schwannoma: + common: + description: >- + A morphologic variant of schwannoma characterized by hypercellularity, Antoni + A pattern, and the absence of well-formed Verocay bodies. + termDef: + term: >- + Cellular Schwannoma + source: NCIt + cde_id: C4724 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4724" + term_id: C4724 + term_version: 20.05a + +cellularity: + common: + description: >- + The determination of the amount of degree, quality or condition of cells present + in a sample. + termDef: + term: >- + Cellularity Measurement + source: NCIt + cde_id: C111153 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111153" + term_id: C111153 + term_version: 20.10d + +cementifying_fibroma: + common: + description: >- + A well circumscribed lesion of the bone, most frequently arising from the posterior + mandible. It is characterized by the presence of fibrous tissue and a mineralized + component which may be woven bone, lamellar bone, or cementum-like material. + Complete removal is recommended, since it continues to enlarge if left untreated. + termDef: + term: >- + Ossifying Fibroma + source: NCIt + cde_id: C8422 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8422" + term_id: C8422 + term_version: 20.05a + +cementoblastoma_benign: + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the jaw. It is a well-circumscribed + lytic tumor that varies in size. The cell of origin is the cementoblast. + termDef: + term: >- + Cementoblastoma + source: NCIt + cde_id: C4308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4308" + term_id: C4308 + term_version: 20.05a + +cementoma_nos: + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the jaw. It is a well-circumscribed + lytic tumor that varies in size. The cell of origin is the cementoblast. + termDef: + term: >- + Cementoblastoma + source: NCIt + cde_id: C4308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4308" + term_id: C4308 + term_version: 20.05a + +cementoossifying_fibroma: + common: + description: >- + A well circumscribed lesion of the bone, most frequently arising from the posterior + mandible. It is characterized by the presence of fibrous tissue and a mineralized + component which may be woven bone, lamellar bone, or cementum-like material. + Complete removal is recommended, since it continues to enlarge if left untreated. + termDef: + term: >- + Ossifying Fibroma + source: NCIt + cde_id: C8422 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8422" + term_id: C8422 + term_version: 20.05a + +cenpa: + common: + description: >- + Histone H3-like centromeric protein A (140 aa, ~16 kDa) is encoded by the human + CENPA gene. This protein plays a role in cell cycle progression, cell division + and centromeric nucleosome assembly. + termDef: + term: >- + Histone H3-Like Centromeric Protein A + source: NCIt + cde_id: C152974 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C152974" + term_id: C152974 + term_version: 20.10d + +central_african_republic: + common: + description: >- + A country in central Africa, north of Democratic Republic of the Congo, between + Cameroon and South Sudan. + termDef: + term: >- + Central African Republic + source: NCIt + cde_id: C16409 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16409" + term_id: C16409 + term_version: 19.12e + +central_nervous_system: + common: + description: >- + The part of the nervous system that consists of the brain, spinal cord, and + meninges. + termDef: + term: >- + Central Nervous System + source: NCIt + cde_id: C12438 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12438" + term_id: C12438 + term_version: 20.05a + +central_neuroblastoma: + common: + description: >- + A neuroblastic tumor characterized by the presence of neuroblastic cells, the + absence of ganglion cells, and the absence of a prominent Schwannian stroma + formation. + termDef: + term: >- + Neuroblastoma + source: NCIt + cde_id: C3270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3270" + term_id: C3270 + term_version: 20.05a + +central_neurocytoma: + common: + description: >- + An intraventricular neuronal neoplasm composed of uniform round cells with neuronal + differentiation. It is typically located in the lateral ventricles in the region + of the foramen of Monro. It generally affects young adults and has a favorable + prognosis. (Adapted from WHO) + termDef: + term: >- + Central Neurocytoma + source: NCIt + cde_id: C3791 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3791" + term_id: C3791 + term_version: 20.05a + +central_odontogenic_fibroma: + common: + description: >- + A rare, benign, intraosseous neoplasm arising from tooth-forming tissues in + the mandible and maxilla. It is characterized by the presence of odontogenic + epithelium which is embedded in a fibrous stroma. Local enucleation of the tumor + is curative. + termDef: + term: >- + Odontogenic Fibroma + source: NCIt + cde_id: C4314 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4314" + term_id: C4314 + term_version: 20.05a + +central_osteosarcoma: + common: + description: >- + A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. + The tumor arises from the medullary portion of the bone. It affects the long + bones and most commonly, the distal femur, proximal tibia, and proximal humerus. + Pain with or without a palpable mass is the most common clinical presentation. + It usually has an aggressive growth and may metastasize through the hematogenous + route. The lung is the most frequent site of metastasis. + termDef: + term: >- + Conventional Osteosarcoma + source: NCIt + cde_id: C35870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35870" + term_id: C35870 + term_version: 20.05a + +central_portion_of_breast: + common: + description: >- + The part of the breast which is in the center. + termDef: + term: >- + Central Portion of the Breast + source: NCIt + cde_id: C12300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12300" + term_id: C12300 + term_version: 20.05a + +central_primitive_neuroectodermal_tumor_nos: + common: + description: >- + A term that refers to central nervous system embryonal tumors which are not + fully characterized. This category includes tumors previously designated as + central nervous system primitive neuroectodermal tumors. + termDef: + term: >- + Central Nervous System Embryonal Tumor, Not Otherwise Specified + source: NCIt + cde_id: C5398 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5398" + term_id: C5398 + term_version: 20.05a + +cep89: + common: + description: >- + This gene is involved in cilia formation. + termDef: + term: >- + CEP89 Gene + source: NCIt + cde_id: C122887 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122887" + term_id: C122887 + term_version: 20.10d + +cerebellar_liponeurocytoma: + common: + description: >- + A rare, WHO grade II cerebellar neoplasm which shows consistent neuronal, variable + astrocytic and focal lipomatous differentiation. It occurs in adults, has a + low proliferative potential and usually has a favorable prognosis. (Adapted + from WHO) + termDef: + term: >- + Cerebellar Liponeurocytoma + source: NCIt + cde_id: C6905 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6905" + term_id: C6905 + term_version: 20.05a + +cerebellar_sarcoma_nos: + common: + description: >- + An obsolete term referring to desmoplastic medulloblastoma. + termDef: + term: >- + Cerebellar Sarcoma + source: NCIt + cde_id: C66803 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66803" + term_id: C66803 + term_version: 20.05a + +cerebellum_nos: + common: + description: >- + The portion of the brain located at the base of the skull that is responsible + for balance, equilibrium and movement. + termDef: + term: >- + Cerebellum + source: NCIt + cde_id: C12445 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12445" + term_id: C12445 + term_version: 20.05a + +cereblon_e3_ubiquitin_ligase_modulating_agent_cc99282: + common: + description: >- + A modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN + E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. + Upon administration, cereblon E3 ubiquitin ligase modulating agent CC-99282 + specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase + activity, and targeting certain substrate proteins for ubiquitination. This + induces proteasome-mediated degradation of certain transcription factors, some + of which are transcriptional repressors in T-cells. This leads to modulation + of the immune system, including activation of T-lymphocytes, and downregulation + of the activity of other proteins, some of which play key roles in the proliferation + of certain cancer cell types. CRBN, the substrate recognition component of the + CRL4-CRBN E3 ubiquitin ligase complex, plays a key role in the ubiquitination + of certain proteins. + termDef: + term: >- + Cereblon E3 Ubiquitin Ligase Modulating Agent CC-99282 + source: NCIt + cde_id: C172396 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172396" + term_id: C172396 + term_version: 20.10d + +cerebral_cortex: + common: + description: >- + The outer layer of the cerebrum composed of neurons and unmyelinated nerve fibers. + It is responsible for memory, attention, consciousness and other higher levels + of mental function. + termDef: + term: >- + Cerebral Cortex + source: NCIt + cde_id: C12443 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12443" + term_id: C12443 + term_version: 20.05a + +cerebral_meninges: + common: + description: >- + The membranes that envelop and protect the brain. + termDef: + term: >- + Cerebral Meninges + source: NCIt + cde_id: C12349 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12349" + term_id: C12349 + term_version: 20.05a + +cerebrospinal_fluid: + common: + description: >- + The fluid that is contained within the brain ventricles, the subarachnoid space + and the central canal of the spinal cord. + termDef: + term: >- + Cerebrospinal Fluid + source: NCIt + cde_id: C12692 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12692" + term_id: C12692 + term_version: 20.05a + +cerebrum: + common: + description: >- + The part of the brain that controls muscle functions and also controls speech, + thought, emotions, reading, writing, and learning. The right hemisphere controls + the muscles on the left side of the body, and the left hemisphere controls the + muscles on the right side of the body. + termDef: + term: >- + Cerebral Hemisphere + source: NCIt + cde_id: C12351 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12351" + term_id: C12351 + term_version: 20.05a + +ceruminous_adenocarcinoma: + common: + description: >- + An infiltrating adenocarcinoma derived from ceruminous glands in the external + auditory canal. + termDef: + term: >- + Ceruminous Adenocarcinoma + source: NCIt + cde_id: C4176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4176" + term_id: C4176 + term_version: 20.05a + +ceruminous_adenoma: + common: + description: >- + A benign epithelial neoplasm derived from ceruminous glands in the external + auditory canal. It presents as a grey mass covered by skin. It is characterized + by a proliferation of glands composed of cells with abundant eosinophilic and + granular cytoplasm. + termDef: + term: >- + External Auditory Canal Ceruminous Adenoma + source: NCIt + cde_id: C6088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6088" + term_id: C6088 + term_version: 20.05a + +ceruminous_carcinoma: + common: + description: >- + An infiltrating adenocarcinoma derived from ceruminous glands in the external + auditory canal. + termDef: + term: >- + Ceruminous Adenocarcinoma + source: NCIt + cde_id: C4176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4176" + term_id: C4176 + term_version: 20.05a + +cervical: + common: + description: >- + Any of the lymph nodes located in the neck. + termDef: + term: >- + Cervical Lymph Node + source: NCIt + cde_id: C32298 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32298" + term_id: C32298 + term_version: 20.10d + +cervical_cancer: + common: + description: >- + A carcinoma arising from either the exocervical squamous epithelium or the endocervical + glandular epithelium. The major histologic types of cervical carcinoma are: + squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic + carcinoma and undifferentiated carcinoma. + termDef: + term: >- + Cervical Carcinoma + source: NCIt + cde_id: C9039 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9039" + term_id: C9039 + term_version: 19.12e + +cervical_esophagus: + common: + description: >- + Clinical esophageal segment composed of skeletal muscle. It corresponds to the + superior part of the upper third topographic segment of the esophagus. + termDef: + term: >- + Cervical Esophagus + source: NCIt + cde_id: C12250 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12250" + term_id: C12250 + term_version: 20.05a + +cervical_intraepithelial_neoplasia_grade_iii: + common: + description: >- + Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph + node metastasis. M0: No distant metastasis. (AJCC 6th ed.) + termDef: + term: >- + Stage 0 Cervical Cancer AJCC v6 + source: NCIt + cde_id: C4000 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4000" + term_id: C4000 + term_version: 20.05a + +cervical_intraepithelial_neoplasia_low_grade: + common: + description: >- + Squamous or glandular cervical intraepithelial neoplasia characterized by the + presence of mild dysplastic changes. + termDef: + term: >- + Low Grade Cervical Intraepithelial Neoplasia + source: NCIt + cde_id: C4630 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4630" + term_id: C4630 + term_version: 20.05a + +cervix_uteri: + common: + description: >- + The lower part of the uterus occupying the region between the isthmus of the + uterus and the vagina. It is divided into supravaginal and vaginal portions. + termDef: + term: >- + Cervix Uteri + source: NCIt + cde_id: C12311 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12311" + term_id: C12311 + term_version: 20.05a + +cetuximab_sarotalocan: + common: + description: >- + A chemical conjugate composed of the dye IR700 linked to cetuximab, a monoclonal + antibody directed against the epidermal growth factor receptor (EGFR), with + potential antineoplastic activity. Upon injection of cetuximab sarotalocan, + the cetuximab moiety targets and binds to EGFR-expressing tumor cells, resulting + in the internalization of the conjugate. Upon localized application of near-infrared + (NIR) light, the IR700 dye becomes activated, disrupts the cell membrane and + selectively kills the EGFR-expressing tumor cells. EGFR, a tyrosine kinase receptor, + is overexpressed in a variety of cancers. + termDef: + term: >- + Cetuximab Sarotalocan + source: NCIt + cde_id: C121850 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121850" + term_id: C121850 + term_version: 20.10d + +cevostamab: + common: + description: >- + A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed + of two single-chain variable fragments (scFv), one directed against the tumor-associated + antigen (TAA) Fc receptor-like protein 5 (FCRH5; CD307; FCRL5; IRTA2; BXMAS1) + and one that is directed against the CD3 antigen found on T-lymphocytes, with + potential immunostimulating and antineoplastic activities. Upon administration + of cevostamab, the bispecific antibody binds to both the CD3 antigen on cytotoxic + T-lymphocytes (CTLs) and FCRH5 found on FCRH5-expressing tumor cells. This activates + and crosslinks CTLs with FCRH5-expressing tumor cells, which results in the + CTL-mediated cell death of FCRH5-expressing tumor cells. FCRH5, an immune receptor + translocation-associated protein/Fc receptor homolog (IRTA/FCRH) family member + and a B-cell lineage marker, is overexpressed on myeloma cells. + termDef: + term: >- + Cevostamab + source: NCIt + cde_id: C139549 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139549" + term_id: C139549 + term_version: 20.10d + +chad: + common: + description: >- + A country in central Africa, south of Libya, between Niger and Sudan. + termDef: + term: >- + Chad + source: NCIt + cde_id: C16412 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16412" + term_id: C16412 + term_version: 19.12e + +chchd7: + common: + description: >- + This gene may be involved in stature. + termDef: + term: >- + CHCHD7 Gene + source: NCIt + cde_id: C97403 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97403" + term_id: C97403 + term_version: 20.10d + +chd2: + common: + description: >- + This gene may be involved in the regulation of both gene expression and chromatin + modification. + termDef: + term: >- + CHD2 Gene + source: NCIt + cde_id: C75307 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75307" + term_id: C75307 + term_version: 20.10d + +chd4: + common: + description: >- + This gene is involved in ATP-dependent chromatin remodeling. + termDef: + term: >- + CHD4 Gene + source: NCIt + cde_id: C128251 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128251" + term_id: C128251 + term_version: 20.10d + +cheek_mucosa: + common: + description: >- + The mucosal membranes located on the inside of the cheek, in the buccal cavity. + termDef: + term: >- + Buccal Mucosa + source: NCIt + cde_id: C12505 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12505" + term_id: C12505 + term_version: 20.05a + +chek2: + common: + description: >- + This gene plays a role in cell survival and the negative regulation of cell + growth. + termDef: + term: >- + CHEK2 Gene + source: NCIt + cde_id: C40965 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40965" + term_id: C40965 + term_version: 20.10d + +chemodectoma: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma arising from + paraganglia adjacent to or in the bifurcation of the common carotid artery. Most + patients present with a slow growing, painless mass in the neck. + termDef: + term: >- + Carotid Body Paraganglioma + source: NCIt + cde_id: C2932 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2932" + term_id: C2932 + term_version: 20.05a + +chga: + common: + description: >- + This gene plays a role in the modulation of the neuroendocrine system. + termDef: + term: >- + CHGA Gene + source: NCIt + cde_id: C21167 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21167" + term_id: C21167 + term_version: 20.10d + +chic2: + common: + description: >- + This gene may play a role in vesicular transport. + termDef: + term: >- + CHIC2 Gene + source: NCIt + cde_id: C97406 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97406" + term_id: C97406 + term_version: 20.10d + +chief_cell_adenoma: + common: + description: >- + A parathyroid gland adenoma composed predominantly of neoplastic chief cells. These + cells have either slightly eosinophilic or vacuolated cytoplasm, and round nuclei. + termDef: + term: >- + Parathyroid Gland Chief Cell Adenoma + source: NCIt + cde_id: C4154 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4154" + term_id: C4154 + term_version: 20.05a + +child: + common: + description: >- + An age group comprised of individuals who are not yet an adult. The specific + cut-off age will vary by purpose. + termDef: + term: >- + Child + source: NCIt + cde_id: C16423 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16423" + term_id: C16423 + term_version: 19.12e + +chile: + common: + description: >- + A country in southwestern South America, bordering the South Pacific Ocean, + between Argentina and Peru. + termDef: + term: >- + Chile + source: NCIt + cde_id: C16427 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16427" + term_id: C16427 + term_version: 19.12e + +china: + common: + description: >- + A country in eastern Asia, bordering the East China Sea, Korea Bay, Yellow Sea, + and South China Sea, south of Kazakhstan, Mongolia and Russia. + termDef: + term: >- + China + source: NCIt + cde_id: C16428 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16428" + term_id: C16428 + term_version: 19.12e + +chloroma: + common: + description: >- + A tumor mass composed of myeloblasts or immature myeloid cells. It occurs in + extramedullary sites or the bone. (WHO, 2001) + termDef: + term: >- + Myeloid Sarcoma + source: NCIt + cde_id: C3520 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3520" + term_id: C3520 + term_version: 20.05a + +chlorotoxin_eqcd28cd3zetacd19texpressing_car_tlymphocytes: + common: + description: >- + A preparation of genetically modified T-lymphocytes transduced with a lentiviral + vector expressing a chimeric antigen receptor (CAR) comprised of a CD28 co-stimulatory + signaling domain fused to the zeta chain of the TCR/CD3 complex (CD3zeta), a + truncated form of CD19 (CD19t), an immunoglobulin (Ig) G4-Fc (EQ) spacer, and + a peptide derived from chlorotoxin (CLTX), with potential imaging and antineoplastic + activities. Upon administration, chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing + CAR T-lymphocytes are re-directed to specific tumor cells in the brain inducing + selective toxicity in these tumor cells. CLTX, a 36-amino acid peptide found + in the venom of the deathstalker scorpion (Leiurus quinquestriatus) and a chloride + channel blocker, preferentially binds to glioma (and other neuroectodermal origin) + cells via membrane bound forms of the endopeptidase matrix metalloproteinase-2 + (MMP-2). This may direct the T-lymphocytes to and induce selective toxicity + in MMP-2-expressing tumor cells. Additionally, binding to MMP-2 on glioma cells + may both interfere with transmembrane chloride exchange and inhibit proteolytic + extracellular matrix remodeling by MMP-2, which may further limit the spread + of these tumor cells. MMP-2 is specifically upregulated in gliomas and related + cancers, but is not normally expressed in brain. The CD28 co-stimulatory molecule + signaling domain enhances activation and signaling; its inclusion may increase + proliferation of T-cells and antitumor activity compared to the inclusion of + the CD3 zeta chain alone. IgG4-Fc (EQ) contains two point mutations in its spacer + region which prevents recognition of the CAR by Fc receptors (FcRs) without + altering the ability of the CAR to mediate antigen-specific lysis. CD19t, which + lacks the cytoplasmic signaling tail, provides a non-immunogenic surface marker + that allows for accurate measurement, efficient cell tracking and/or imaging + of the therapeutic T-cells in vivo following adoptive transfer. Additionally, + co-expression of CD19t functions as a "suicide" switch via clinically available + antibodies or immunotoxins which can be used to selectively eliminate the genetically + modified cells. + termDef: + term: >- + Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes + source: NCIt + cde_id: C167056 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167056" + term_id: C167056 + term_version: 20.10d + +cholangiocarcinoma: + common: + description: >- + A carcinoma that arises from the intrahepatic bile ducts, the hepatic ducts, + or the common bile duct distal to the insertion of the cystic duct. The vast + majority of tumors are adenocarcinomas. + termDef: + term: >- + Cholangiocarcinoma + source: NCIt + cde_id: C4436 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4436" + term_id: C4436 + term_version: 20.05a + +cholangioma: + common: + description: >- + A benign, well-demarcated polypoid neoplasm arising from the bile duct epithelium. + According to the growth pattern, it is classified as tubular, papillary, or + tubulopapillary. Adenomas arising from the extrahepatic bile ducts usually produce + symptoms related to biliary obstruction. + termDef: + term: >- + Bile Duct Adenoma + source: NCIt + cde_id: C2942 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2942" + term_id: C2942 + term_version: 20.05a + +chondroblastic_osteosarcoma: + common: + description: >- + An osteosarcoma characterised by the presence of atypical cartilage of variable + cellularity. It may or may not be associated with the presence of myxoid areas + or focal bone formation. + termDef: + term: >- + Chondroblastic Osteosarcoma + source: NCIt + cde_id: C4021 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4021" + term_id: C4021 + term_version: 20.05a + +chondroblastoma_nos: + common: + description: >- + A benign, chondroid-producing, well-circumscribed, lytic neoplasm usually arising + from the epiphysis of long bones. It is characterized by the presence of chondroblasts, + osteoclast-like giant cells, chondroid formation, calcification, and mitotic + activity. In aggressive cases, there is rearrangement of the 8q21 chromosome + band. It occurs most frequently in children and young adults and rarely metastasizes. + termDef: + term: >- + Chondroblastoma + source: NCIt + cde_id: C2945 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2945" + term_id: C2945 + term_version: 20.05a + +chondroid_chordoma: + common: + description: >- + A slow-growing malignant bone tumor arising from the remnants of the notochord + and occurring in the base of the skull. The tumor is characterized by a lobulated + growth pattern, myxoid stroma formation, and the presence of physaliphorous + cells and cartilage. + termDef: + term: >- + Chondroid Chordoma + source: NCIt + cde_id: C6902 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6902" + term_id: C6902 + term_version: 20.05a + +chondroid_lipoma: + common: + description: >- + A rare benign adipose tissue neoplasm characterized by nests and cord of abundant + univacuolated and multivacuolated lipoblasts and mature adipocytes in a prominent + myxoid to hyalinized chondroid matrix admix. It predominantly affects females. + termDef: + term: >- + Chondroid Lipoma + source: NCIt + cde_id: C6503 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6503" + term_id: C6503 + term_version: 20.05a + +chondroid_syringoma: + common: + description: >- + A rare, benign, slow-growing and painless neoplasm of sweat glands. It usually + arises in the head and neck. It is characterized by the presence of a mesenchymal + chondroid stroma, fibrosis, and epithelial structures. + termDef: + term: >- + Benign Mixed Tumor of the Skin + source: NCIt + cde_id: C4474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4474" + term_id: C4474 + term_version: 20.05a + +chondroma_nos: + common: + description: >- + A benign well circumscribed neoplasm of hyaline cartilage arising from bone + or soft tissue. It is characterized by the presence of chondrocytes. + termDef: + term: >- + Chondroma + source: NCIt + cde_id: C53459 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53459" + term_id: C53459 + term_version: 20.05a + +chondromatosis_nos: + common: + description: >- + A multifocal benign neoplasm arising from bone or soft tissue. It is characterized + by the presence of chondrocytes and is composed of hyaline cartilage. + termDef: + term: >- + Chondromatosis + source: NCIt + cde_id: C35259 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35259" + term_id: C35259 + term_version: 20.05a + +chondromatous_giant_cell_tumor: + common: + description: >- + A benign, chondroid-producing, well-circumscribed, lytic neoplasm usually arising + from the epiphysis of long bones. It is characterized by the presence of chondroblasts, + osteoclast-like giant cells, chondroid formation, calcification, and mitotic + activity. In aggressive cases, there is rearrangement of the 8q21 chromosome + band. It occurs most frequently in children and young adults and rarely metastasizes. + termDef: + term: >- + Chondroblastoma + source: NCIt + cde_id: C2945 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2945" + term_id: C2945 + term_version: 20.05a + +chondromyxoid_fibroma: + common: + description: >- + An uncommon benign cartilaginous neoplasm arising from the bone. It is characterized + by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth + pattern, myxoid stroma formation, and sometimes multinucleated giant cells. + It has been associated with chromosomal rearrangement of 6q13 and 6q25 bands. + The most common clinical symptom is mild, localized pain. + termDef: + term: >- + Chondromyxoid Fibroma + source: NCIt + cde_id: C3830 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3830" + term_id: C3830 + term_version: 20.05a + +chondrosarcoma: + common: + description: >- + A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from + the bone and soft tissue. It usually affects middle-aged to elderly adults. + The pelvic bones, ribs, shoulder girdle, and long bones are the most common + sites of involvement. Most chondrosarcomas arise de novo, but some may develop + in a preexisting benign cartilaginous lesion. + termDef: + term: >- + Chondrosarcoma + source: NCIt + cde_id: C2946 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2946" + term_id: C2946 + term_version: 19.12e + +chondrosarcoma_nos: + common: + description: >- + A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from + the bone and soft tissue. It usually affects middle-aged to elderly adults. The + pelvic bones, ribs, shoulder girdle, and long bones are the most common sites + of involvement. Most chondrosarcomas arise de novo, but some may develop in + a preexisting benign cartilaginous lesion. + termDef: + term: >- + Chondrosarcoma + source: NCIt + cde_id: C2946 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2946" + term_id: C2946 + term_version: 20.05a + +chordoid_glioma: + common: + description: >- + A rare, slow-growing neuroepithelial neoplasm of uncertain origin affecting + adults. It is located in the third ventricle. It is characterized by the presence + of epithelioid cells which express GFAP, and mucinous stroma which contains + lymphoplasmacytic infiltrates. + termDef: + term: >- + Chordoid Glioma of the Third Ventricle + source: NCIt + cde_id: C5592 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5592" + term_id: C5592 + term_version: 20.05a + +chordoid_glioma_of_third_ventricle: + common: + description: >- + A rare, slow-growing neuroepithelial neoplasm of uncertain origin affecting + adults. It is located in the third ventricle. It is characterized by the presence + of epithelioid cells which express GFAP, and mucinous stroma which contains + lymphoplasmacytic infiltrates. + termDef: + term: >- + Chordoid Glioma of the Third Ventricle + source: NCIt + cde_id: C5592 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5592" + term_id: C5592 + term_version: 20.05a + +chordoid_meningioma: + common: + description: >- + A WHO grade II, usually recurring meningioma characterized by the predominance + of tissues that are histologically similar to chordoma. + termDef: + term: >- + Chordoid Meningioma + source: NCIt + cde_id: C6908 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6908" + term_id: C6908 + term_version: 20.05a + +chordoma_nos: + common: + description: >- + A malignant bone tumor arising from the remnants of the fetal notochord. Although + it can occur at all ages, it is more frequently seen in middle-aged adults. + The most frequent sites of involvement are the sacrococcygeal area, spheno-occipital + area, and cervico-thoraco-lumbar spine. Microscopically, chordomas are composed + of cells that form cords and lobules, separated by mucoid intercellular tissue. + Some of the cells are large (physaliphorous) and have vacuolated cytoplasm and + prominent vesicular nuclei. Other tumor cells are small with small nuclei without + visible nucleoli. Chordomas tend to recur and may metastasize. The most common + sites of metastasis are the skin and bone. + termDef: + term: >- + Chordoma + source: NCIt + cde_id: C2947 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2947" + term_id: C2947 + term_version: 20.05a + +chorioadenoma: + common: + description: >- + A complete hydatidiform mole or very rarely a partial mole that invades the + myometrium. + termDef: + term: >- + Invasive Hydatidiform Mole + source: NCIt + cde_id: C6985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6985" + term_id: C6985 + term_version: 20.05a + +chorioadenoma_destruens: + common: + description: >- + A complete hydatidiform mole or very rarely a partial mole that invades the + myometrium. + termDef: + term: >- + Invasive Hydatidiform Mole + source: NCIt + cde_id: C6985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6985" + term_id: C6985 + term_version: 20.05a + +chorioangioma: + common: + description: >- + A hemangioma arising from the fetal blood vessels in the placental villi. + termDef: + term: >- + Placental Hemangioma + source: NCIt + cde_id: C4868 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4868" + term_id: C4868 + term_version: 20.05a + +choriocarcinoma_combined_with_embryonal_carcinoma: + common: + description: >- + A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous + component admixed with another germ cell component (e.g. embryonal carcinoma, + teratoma, or seminoma). + termDef: + term: >- + Choriocarcinoma Combined with Other Germ Cell Elements + source: NCIt + cde_id: C66777 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66777" + term_id: C66777 + term_version: 20.05a + +choriocarcinoma_combined_with_other_germ_cell_elements: + common: + description: >- + A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous + component admixed with another germ cell component (e.g. embryonal carcinoma, + teratoma, or seminoma). + termDef: + term: >- + Choriocarcinoma Combined with Other Germ Cell Elements + source: NCIt + cde_id: C66777 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66777" + term_id: C66777 + term_version: 20.05a + +choriocarcinoma_nos: + common: + description: >- + An aggressive malignant tumor arising from trophoblastic cells. The vast majority + of cases arise in the uterus and represent gestational choriocarcinomas that + derive from placental trophoblastic cells. Approximately half of the cases develop + from a complete hydatidiform mole. A minority of cases arise in the testis or + the ovaries. There is often marked elevation of human chorionic gonadotropin + (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous + route; the lungs are most frequently affected. + termDef: + term: >- + Choriocarcinoma + source: NCIt + cde_id: C2948 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2948" + term_id: C2948 + term_version: 20.05a + +chorioepithelioma: + common: + description: >- + An aggressive malignant tumor arising from trophoblastic cells. The vast majority + of cases arise in the uterus and represent gestational choriocarcinomas that + derive from placental trophoblastic cells. Approximately half of the cases develop + from a complete hydatidiform mole. A minority of cases arise in the testis or + the ovaries. There is often marked elevation of human chorionic gonadotropin + (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous + route; the lungs are most frequently affected. + termDef: + term: >- + Choriocarcinoma + source: NCIt + cde_id: C2948 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2948" + term_id: C2948 + term_version: 20.05a + +chorionepithelioma: + common: + description: >- + An aggressive malignant tumor arising from trophoblastic cells. The vast majority + of cases arise in the uterus and represent gestational choriocarcinomas that + derive from placental trophoblastic cells. Approximately half of the cases develop + from a complete hydatidiform mole. A minority of cases arise in the testis or + the ovaries. There is often marked elevation of human chorionic gonadotropin + (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous + route; the lungs are most frequently affected. + termDef: + term: >- + Choriocarcinoma + source: NCIt + cde_id: C2948 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2948" + term_id: C2948 + term_version: 20.05a + +choroid: + common: + description: >- + A blood vessel-containing membrane of the eye that lies between the retina and + the sclera. + termDef: + term: >- + Choroid + source: NCIt + cde_id: C12344 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12344" + term_id: C12344 + term_version: 20.05a + +choroid_plexus_carcinoma: + common: + description: >- + A malignant neoplasm arising from the choroid plexus. It shows anaplastic features + and usually invades neighboring brain structures. Cerebrospinal fluid metastases + are frequent. (Adapted from WHO) + termDef: + term: >- + Choroid Plexus Carcinoma + source: NCIt + cde_id: C4715 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4715" + term_id: C4715 + term_version: 20.05a + +choroid_plexus_papilloma_anaplastic: + common: + description: >- + A malignant neoplasm arising from the choroid plexus. It shows anaplastic features + and usually invades neighboring brain structures. Cerebrospinal fluid metastases + are frequent. (Adapted from WHO) + termDef: + term: >- + Choroid Plexus Carcinoma + source: NCIt + cde_id: C4715 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4715" + term_id: C4715 + term_version: 20.05a + +choroid_plexus_papilloma_malignant: + common: + description: >- + A malignant neoplasm arising from the choroid plexus. It shows anaplastic features + and usually invades neighboring brain structures. Cerebrospinal fluid metastases + are frequent. (Adapted from WHO) + termDef: + term: >- + Choroid Plexus Carcinoma + source: NCIt + cde_id: C4715 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4715" + term_id: C4715 + term_version: 20.05a + +choroid_plexus_papilloma_nos: + common: + description: >- + A benign, slow growing tumor which may cause symptoms by blocking cerebrospinal + fluid pathways. It is characterized by the presence of delicate fibrovascular + connective tissue fronds covered by a single layer of epithelial cells. Mitotic + activity is extremely low. Surgical resection is usually curative. (Adapted + from WHO) + termDef: + term: >- + Choroid Plexus Papilloma + source: NCIt + cde_id: C3698 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3698" + term_id: C3698 + term_version: 20.05a + +chr1: + common: + description: >- + The designation for each member of the largest human autosomal chromosome pair. + Chromosome 1 spans about 247 million nucleotide base pairs and represents about + 8% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 1 + source: NCIt + cde_id: C13204 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13204" + term_id: C13204 + term_version: 20.10d + +chr10: + common: + description: >- + The designation for each member of the tenth largest human autosomal chromosome + pair. Chromosome 10 spans about 135 million base pairs and represents between + 4 and 4.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 10 + source: NCIt + cde_id: C13205 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13205" + term_id: C13205 + term_version: 20.10d + +chr11: + common: + description: >- + The designation for each member of the eleventh largest human autosomal chromosome + pair. Chromosome 11 spans about 134.5 million base pairs and represents between + 4 and 4.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 11 + source: NCIt + cde_id: C13206 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13206" + term_id: C13206 + term_version: 20.10d + +chr12: + common: + description: >- + The designation for each member of the twelfth largest human autosomal chromosome + pair. Chromosome 12 spans about 143 million base pairs and represents between + 4 and 4.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 12 + source: NCIt + cde_id: C13207 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13207" + term_id: C13207 + term_version: 20.10d + +chr13: + common: + description: >- + The designation for each member of the thirteenth largest human autosomal chromosome + pair. Chromosome 13 spans about 113 million base pairs and represents between + 3.5 and 4% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 13 + source: NCIt + cde_id: C13208 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13208" + term_id: C13208 + term_version: 20.10d + +chr14: + common: + description: >- + The designation for each member of the fourteenth largest human autosomal chromosome + pair. Chromosome 14 spans about 105 million base pairs and represents between + 3 and 3.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 14 + source: NCIt + cde_id: C13209 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13209" + term_id: C13209 + term_version: 20.10d + +chr15: + common: + description: >- + The designation for each member of the fifteenth largest human autosomal chromosome + pair. Chromosome 15 spans about 106 million base pairs and represents between + 3 and 3.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 15 + source: NCIt + cde_id: C13210 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13210" + term_id: C13210 + term_version: 20.10d + +chr16: + common: + description: >- + The designation for each member of the sixteenth largest human autosomal chromosome + pair. Chromosome 16 spans about 90 million base pairs and represents just under + 3% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 16 + source: NCIt + cde_id: C13211 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13211" + term_id: C13211 + term_version: 20.10d + +chr17: + common: + description: >- + The designation for each member of the seventeenth largest human autosomal chromosome + pair. Chromosome 17 spans more than 81 million base pairs and represents between + 2.5 and 3% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 17 + source: NCIt + cde_id: C13212 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13212" + term_id: C13212 + term_version: 20.10d + +chr18: + common: + description: >- + The designation for each member of the eighteenth largest human autosomal chromosome + pair. Chromosome 18 spans about 76 million base pairs and represents about 2.5% + of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 18 + source: NCIt + cde_id: C13213 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13213" + term_id: C13213 + term_version: 20.10d + +chr19: + common: + description: >- + The designation for each member of the nineteenth largest human autosomal chromosome + pair. Chromosome 19 spans more than 63 million base pairs and represents between + 2 and 2.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 19 + source: NCIt + cde_id: C13214 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13214" + term_id: C13214 + term_version: 20.10d + +chr2: + common: + description: >- + The designation for each member of the second largest human autosomal chromosome + pair. Chromosome 2 spans more than 237 million base pairs and represents almost + 8% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 2 + source: NCIt + cde_id: C13215 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13215" + term_id: C13215 + term_version: 20.10d + +chr20: + common: + description: >- + The designation for each member of the third smallest human autosomal chromosome + pair. Chromosome 20 spans around 63 million base pairs and represents between + 2 and 2.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 20 + source: NCIt + cde_id: C13216 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13216" + term_id: C13216 + term_version: 20.10d + +chr21: + common: + description: >- + The designation for each member of the second smallest human autosomal chromosome + pair. Chromosome 21 spans around 47 million nucleotides and represents about + 1.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 21 + source: NCIt + cde_id: C13217 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13217" + term_id: C13217 + term_version: 20.10d + +chr22: + common: + description: >- + The designation for each member of the smallest human autosomal chromosome pair. + Chromosome 22 spans about 49 million base pairs and represents between 1.5 and + 2% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 22 + source: NCIt + cde_id: C13218 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13218" + term_id: C13218 + term_version: 20.10d + +chr23: + common: + description: >- + The X or Y chromosome in human beings that determines the sex of an individual. + Females have two X chromosomes in diploid cells; males have an X and a Y chromosome. + The sex chromosomes comprise the 23rd chromosome pair in a human karyotype. + termDef: + term: >- + Sex Chromosome + source: NCIt + cde_id: C33542 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33542" + term_id: C33542 + term_version: 20.10d + +chr3: + common: + description: >- + The designation for each member of the third largest human autosomal chromosome + pair. Chromosome 3 spans almost 200 million base pairs and represents about + 6.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 3 + source: NCIt + cde_id: C13219 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13219" + term_id: C13219 + term_version: 20.10d + +chr4: + common: + description: >- + The designation for each member of the fourth largest human autosomal chromosome + pair. Chromosome 4 spans more than 186 million base pairs and represents between + 6 and 6.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 4 + source: NCIt + cde_id: C13220 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13220" + term_id: C13220 + term_version: 20.10d + +chr5: + common: + description: >- + The designation for each member of the fifth largest human autosomal chromosome + pair. Chromosome 5 spans about 181 million base pairs and represents almost + 6% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 5 + source: NCIt + cde_id: C13221 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13221" + term_id: C13221 + term_version: 20.10d + +chr6: + common: + description: >- + The designation for each member of the sixth largest human autosomal chromosome + pair. Chromosome 6 spans more than 170 million base pairs and represents between + 5.5 and 6% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 6 + source: NCIt + cde_id: C13222 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13222" + term_id: C13222 + term_version: 20.10d + +chr7: + common: + description: >- + The designation for each member of the seventh largest human autosomal chromosome + pair. Chromosome 7 spans more than 158 million base pairs and represents between + 5 and 5.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 7 + source: NCIt + cde_id: C13223 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13223" + term_id: C13223 + term_version: 20.10d + +chr8: + common: + description: >- + The designation for each member of the eighth largest human autosomal chromosome + pair. Chromosome 8 spans about 145 million base pairs and represents between + 4.5 and 5.0% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 8 + source: NCIt + cde_id: C13224 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13224" + term_id: C13224 + term_version: 20.10d + +chr9: + common: + description: >- + The designation for each member of the ninth largest human autosomal chromosome + pair. Chromosome 9 spans about 145 million base pairs of nucleic acids and represents + between 4 and 4.5% of the total DNA in normal diploid cells. + termDef: + term: >- + Chromosome 9 + source: NCIt + cde_id: C13225 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13225" + term_id: C13225 + term_version: 20.10d + +chrimerism: + common: + description: >- + The occurrence in an individual of two or more cell populations of different + chromosomal constitutions, derived from different individuals. This contrasts + with mosaicism in which the different cell populations are derived from a single + individual. + termDef: + term: >- + Chimerism + source: NCIt + cde_id: C62582 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62582" + term_id: C62582 + term_version: 20.10d + +chrm: + common: + description: >- + Typically small, circular, intronless, and maternally inherited, mitochondrial + DNA (mtDNA) is the multicopy deoxyribonucleic acid genome of mitochondria, intracellular + organelles responsible for vital respiratory chain and oxidative phosphorylation + reactions in higher eukaryotes. Replicated and transcribed by a separate enzymatic + machinery from that of nuclear DNA, mtDNA encodes only a subset of mitochondrial + functions. (NCI04) + termDef: + term: >- + Mitochondrial DNA + source: NCIt + cde_id: C28512 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28512" + term_id: C28512 + term_version: 20.10d + +chromaffin_paraganglioma: + common: + description: >- + A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system + that secretes catecholamines. It arises from the chromaffin cells of the adrenal + medulla. Clinical presentation includes headaches, palpitations, chest and + abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic + nesting (zellballen) growth pattern is usually seen. Other growth patterns + including trabecular pattern may also be present. + termDef: + term: >- + Adrenal Gland Pheochromocytoma + source: NCIt + cde_id: C3326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3326" + term_id: C3326 + term_version: 20.05a + +chromaffin_tumor: + common: + description: >- + A benign or malignant paraganglioma arising from the chromaffin cells of the + paraganglia that are located along the sympathetic nerves. It includes extra-adrenal + paragangliomas and paragangliomas that arise from the adrenal medulla. The + latter are commonly referred to as pheochromocytomas. Representative examples + of extra-adrenal sympathetic paragangliomas include the bladder, and superior + and inferior paraaortic paragangliomas. Clinical signs are related to the secretion + of catecholamines resulting in hypertension. + termDef: + term: >- + Sympathetic Paraganglioma + source: NCIt + cde_id: C4216 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4216" + term_id: C4216 + term_version: 20.05a + +chromaffinoma: + common: + description: >- + A benign or malignant paraganglioma arising from the chromaffin cells of the + paraganglia that are located along the sympathetic nerves. It includes extra-adrenal + paragangliomas and paragangliomas that arise from the adrenal medulla. The + latter are commonly referred to as pheochromocytomas. Representative examples + of extra-adrenal sympathetic paragangliomas include the bladder, and superior + and inferior paraaortic paragangliomas. Clinical signs are related to the secretion + of catecholamines resulting in hypertension. + termDef: + term: >- + Sympathetic Paraganglioma + source: NCIt + cde_id: C4216 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4216" + term_id: C4216 + term_version: 20.05a + +chromogranin_a: + common: + description: >- + The determination of the amount of chromogranin A present in a sample. + termDef: + term: >- + Chromogranin A Measurement + source: NCIt + cde_id: C122108 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122108" + term_id: C122108 + term_version: 20.10d + +chromogranin_b: + common: + description: >- + The determination of the amount of chromogranin B present in a sample. + termDef: + term: >- + Chromogranin B Measurement + source: NCIt + cde_id: C174116 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174116" + term_id: C174116 + term_version: 20.10d + +chromophobe_adenocarcinoma: + common: + description: >- + A type of carcinoma that comprises a minority of renal cell carcinomas. It + is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics + of the neoplastic cells, this type of carcinoma is classified as classic (typical) + or eosinophilic. It has a much better prognosis than other renal cell carcinomas. + termDef: + term: >- + Chromophobe Renal Cell Carcinoma + source: NCIt + cde_id: C4146 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4146" + term_id: C4146 + term_version: 20.05a + +chromophobe_adenoma: + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells do not stain with acidic or basic dyes. + termDef: + term: >- + Pituitary Gland Chromophobe Adenoma + source: NCIt + cde_id: C2857 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2857" + term_id: C2857 + term_version: 20.05a + +chromophobe_carcinoma: + common: + description: >- + A type of carcinoma that comprises a minority of renal cell carcinomas. It + is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics + of the neoplastic cells, this type of carcinoma is classified as classic (typical) + or eosinophilic. It has a much better prognosis than other renal cell carcinomas. + termDef: + term: >- + Chromophobe Renal Cell Carcinoma + source: NCIt + cde_id: C4146 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4146" + term_id: C4146 + term_version: 20.05a + +chromophobe_cell_renal_carcinoma: + common: + description: >- + A type of carcinoma that comprises a minority of renal cell carcinomas. It + is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics + of the neoplastic cells, this type of carcinoma is classified as classic (typical) + or eosinophilic. It has a much better prognosis than other renal cell carcinomas. + termDef: + term: >- + Chromophobe Renal Cell Carcinoma + source: NCIt + cde_id: C4146 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4146" + term_id: C4146 + term_version: 20.05a + +chronic_eosinophilic_leukemia_nos: + common: + description: >- + A rare myeloproliferative neoplasm characterized by a clonal proliferation of + eosinophilic precursors resulting in persistently increased numbers of eosinophils + in the blood, marrow and peripheral tissues. Since acute eosinophilic leukemia + is at best exceedingly rare, the term eosinophilic leukemia is normally used + as a synonym for chronic eosinophilic leukemia. In cases in which it is impossible + to prove clonality and there is no increase in blast cells, the diagnosis of + "idiopathic hypereosinophilic syndrome" is preferred. (WHO, 2001) + termDef: + term: >- + Chronic Eosinophilic Leukemia, Not Otherwise Specified + source: NCIt + cde_id: C4563 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4563" + term_id: C4563 + term_version: 20.05a + +chronic_granulocytic_leukemia_bcrabl: + common: + description: >- + A chronic myelogenous leukemia characterised by the t(9;22)(q34;q11) chromosomal + translocation, resulting in the presence of the Philadelphia chromosome and + the BCR-ABL1 fusion gene. + termDef: + term: >- + Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia + source: NCIt + cde_id: C9128 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9128" + term_id: C9128 + term_version: 20.05a + +chronic_granulocytic_leukemia_nos: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by the expression of the + BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear + at any age, but it mostly affects middle aged and older individuals. Patients + usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. + If untreated, it follows a biphasic or triphasic natural course; an initial + indolent chronic phase which is followed by an accelerated phase, a blast phase, + or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors + delay disease progression and prolong overall survival. + termDef: + term: >- + Chronic Myelogenous Leukemia, BCR-ABL1 Positive + source: NCIt + cde_id: C3174 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3174" + term_id: C3174 + term_version: 20.05a + +chronic_granulocytic_leukemia_philadelphia_chromosome_ph1_positive: + common: + description: >- + A chronic myelogenous leukemia characterised by the t(9;22)(q34;q11) chromosomal + translocation, resulting in the presence of the Philadelphia chromosome and + the BCR-ABL1 fusion gene. + termDef: + term: >- + Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia + source: NCIt + cde_id: C9128 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9128" + term_id: C9128 + term_version: 20.05a + +chronic_granulocytic_leukemia_t922q34q11: + common: + description: >- + A chronic myelogenous leukemia characterised by the t(9;22)(q34;q11) chromosomal + translocation, resulting in the presence of the Philadelphia chromosome and + the BCR-ABL1 fusion gene. + termDef: + term: >- + Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia + source: NCIt + cde_id: C9128 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9128" + term_id: C9128 + term_version: 20.05a + +chronic_idiopathic_myelofibrosis: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, + proliferation of atypical megakaryocytes and granulocytes in the bone marrow, + anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001) + termDef: + term: >- + Primary Myelofibrosis + source: NCIt + cde_id: C2862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2862" + term_id: C2862 + term_version: 20.05a + +chronic_leukemia_nos: + common: + description: >- + A slowly progressing leukemia characterized by a clonal (malignant) proliferation + of maturing and mature myeloid cells or mature lymphocytes. When the clonal + cellular population is composed of myeloid cells, the process is called chronic + myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, + it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell + large granular lymphocyte leukemia. + termDef: + term: >- + Chronic Leukemia + source: NCIt + cde_id: C3483 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3483" + term_id: C3483 + term_version: 20.05a + +chronic_lymphatic_leukemia: + common: + description: >- + The most common type of chronic lymphoid leukemia. It comprises 90% of chronic + lymphoid leukemias in the United States. Morphologically, the neoplastic cells + are small, round B-lymphocytes. This type of leukemia is not considered to + be curable with available therapy. (WHO, 2001) + termDef: + term: >- + Chronic Lymphocytic Leukemia + source: NCIt + cde_id: C3163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3163" + term_id: C3163 + term_version: 20.05a + +chronic_lymphocytic_leukemia: + common: + description: >- + The most common type of chronic lymphoid leukemia. It comprises 90% of chronic + lymphoid leukemias in the United States. Morphologically, the neoplastic cells + are small, round B-lymphocytes. This type of leukemia is not considered to + be curable with available therapy. (WHO, 2001) + termDef: + term: >- + Chronic Lymphocytic Leukemia + source: NCIt + cde_id: C3163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3163" + term_id: C3163 + term_version: 20.05a + +chronic_lymphocytic_leukemia_bcell_type_includes_all_variants_of_bcll: + common: + description: >- + The most common type of chronic lymphoid leukemia. It comprises 90% of chronic + lymphoid leukemias in the United States. Morphologically, the neoplastic cells + are small, round B-lymphocytes. This type of leukemia is not considered to + be curable with available therapy. (WHO, 2001) + termDef: + term: >- + Chronic Lymphocytic Leukemia + source: NCIt + cde_id: C3163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3163" + term_id: C3163 + term_version: 20.05a + +chronic_lymphoid_leukemia: + common: + description: >- + The most common type of chronic lymphoid leukemia. It comprises 90% of chronic + lymphoid leukemias in the United States. Morphologically, the neoplastic cells + are small, round B-lymphocytes. This type of leukemia is not considered to + be curable with available therapy. (WHO, 2001) + termDef: + term: >- + Chronic Lymphocytic Leukemia + source: NCIt + cde_id: C3163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3163" + term_id: C3163 + term_version: 20.05a + +chronic_lymphoproliferative_disorder_of_nk_cells: + common: + description: >- + An Epstein-Barr virus negative disorder with a chronic clinical course affecting + predominantly adults and characterized by the proliferation of large granular + lymphocytes with natural killer cell immunophenotype. The T-cell receptor genes + are not rearranged. + termDef: + term: >- + Chronic Lymphoproliferative Disorder of NK-Cells + source: NCIt + cde_id: C39591 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39591" + term_id: C39591 + term_version: 20.05a + +chronic_monocytic_leukemia: + common: + description: >- + Chronic Monocytic Leukemia + termDef: + term: >- + Chronic Monocytic Leukemia + source: NCIt + cde_id: C34774 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C34774" + term_id: C34774 + term_version: 20.05a + +chronic_myelocytic_leukemia_nos: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by the expression of the + BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear + at any age, but it mostly affects middle aged and older individuals. Patients + usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. + If untreated, it follows a biphasic or triphasic natural course; an initial + indolent chronic phase which is followed by an accelerated phase, a blast phase, + or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors + delay disease progression and prolong overall survival. + termDef: + term: >- + Chronic Myelogenous Leukemia, BCR-ABL1 Positive + source: NCIt + cde_id: C3174 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3174" + term_id: C3174 + term_version: 20.05a + +chronic_myelogenous_leukemia_bcrabl_positive: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by the expression of the + BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear + at any age, but it mostly affects middle aged and older individuals. Patients + usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. + If untreated, it follows a biphasic or triphasic natural course; an initial + indolent chronic phase which is followed by an accelerated phase, a blast phase, + or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors + delay disease progression and prolong overall survival. + termDef: + term: >- + Chronic Myelogenous Leukemia, BCR-ABL1 Positive + source: NCIt + cde_id: C3174 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3174" + term_id: C3174 + term_version: 20.05a + +chronic_myelogenous_leukemia_philadelphia_chromosome_ph_1_positive: + common: + description: >- + A chronic myelogenous leukemia characterised by the t(9;22)(q34;q11) chromosomal + translocation, resulting in the presence of the Philadelphia chromosome and + the BCR-ABL1 fusion gene. + termDef: + term: >- + Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia + source: NCIt + cde_id: C9128 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9128" + term_id: C9128 + term_version: 20.05a + +chronic_myelogenous_leukemia_t922q34q11: + common: + description: >- + A chronic myelogenous leukemia characterised by the t(9;22)(q34;q11) chromosomal + translocation, resulting in the presence of the Philadelphia chromosome and + the BCR-ABL1 fusion gene. + termDef: + term: >- + Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia + source: NCIt + cde_id: C9128 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9128" + term_id: C9128 + term_version: 20.05a + +chronic_myeloid_leukemia_nos: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by the expression of the + BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear + at any age, but it mostly affects middle aged and older individuals. Patients + usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. + If untreated, it follows a biphasic or triphasic natural course; an initial + indolent chronic phase which is followed by an accelerated phase, a blast phase, + or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors + delay disease progression and prolong overall survival. + termDef: + term: >- + Chronic Myelogenous Leukemia, BCR-ABL1 Positive + source: NCIt + cde_id: C3174 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3174" + term_id: C3174 + term_version: 20.05a + +chronic_myelomonocytic_leukemia_in_transformation: + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent + monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer + than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence + of PDGFRA or PDGFRB rearrangement. + termDef: + term: >- + Chronic Myelomonocytic Leukemia + source: NCIt + cde_id: C3178 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3178" + term_id: C3178 + term_version: 20.05a + +chronic_myelomonocytic_leukemia_nos: + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent + monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer + than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence + of PDGFRA or PDGFRB rearrangement. + termDef: + term: >- + Chronic Myelomonocytic Leukemia + source: NCIt + cde_id: C3178 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3178" + term_id: C3178 + term_version: 20.05a + +chronic_myeloproliferative_disease_nos: + common: + description: >- + A clonal hematopoietic stem cell disorder, characterized by proliferation in + the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, + megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. + (WHO 2008) + termDef: + term: >- + Myeloproliferative Neoplasm + source: NCIt + cde_id: C4345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4345" + term_id: C4345 + term_version: 20.05a + +chronic_myeloproliferative_disorder: + common: + description: >- + A clonal hematopoietic stem cell disorder, characterized by proliferation in + the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, + megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. + (WHO 2008) + termDef: + term: >- + Myeloproliferative Neoplasm + source: NCIt + cde_id: C4345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4345" + term_id: C4345 + term_version: 20.05a + +chronic_neutrophilic_leukemia: + common: + description: >- + A rare chronic myeloproliferative neoplasm characterized by neutrophilic leukocytosis. There + is no detectable Philadelphia chromosome or BCR/ABL fusion gene. + termDef: + term: >- + Chronic Neutrophilic Leukemia + source: NCIt + cde_id: C3179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3179" + term_id: C3179 + term_version: 20.05a + +chrx: + common: + description: >- + The sex chromosome that is present in both sexes: singly in males and doubly + in females. + termDef: + term: >- + Chromosome X + source: NCIt + cde_id: C13285 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13285" + term_id: C13285 + term_version: 20.10d + +chry: + common: + description: >- + The y-shaped sex chromosome. In mammals, its presence or absence determines + male or female sex. + termDef: + term: >- + Chromosome Y + source: NCIt + cde_id: C13286 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13286" + term_id: C13286 + term_version: 20.10d + +chst11: + common: + description: >- + This gene plays a role in the metabolism of chondroitin sulfate. + termDef: + term: >- + CHST11 Gene + source: NCIt + cde_id: C143061 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143061" + term_id: C143061 + term_version: 20.10d + +cic: + common: + description: >- + This gene is involved in the modulation of transcription. + termDef: + term: >- + CIC Gene + source: NCIt + cde_id: C97912 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97912" + term_id: C97912 + term_version: 20.10d + +cigar: + common: + description: >- + A compact roll of tobacco leaves prepared for smoking. + termDef: + term: >- + Cigar + source: NCIt + cde_id: C1813 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1813" + term_id: C1813 + term_version: 19.12e + +cigarette: + common: + description: >- + Finely cut tobacco encased in a wrapper of thin paper and rolled for smoking. + termDef: + term: >- + Cigarette + source: NCIt + cde_id: C1802 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1802" + term_id: C1802 + term_version: 19.12e + +ciita: + common: + description: >- + This gene plays a role in transcriptional regulation. + termDef: + term: >- + CIITA Gene + source: NCIt + cde_id: C96013 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96013" + term_id: C96013 + term_version: 20.10d + +ciliary_body: + common: + description: >- + Tissue located behind the iris and composed of muscle and epithelium. Its functions + include the production of aqueous humor and changing the shape of the crystalline + lens. + termDef: + term: >- + Ciliary Body + source: NCIt + cde_id: C12345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12345" + term_id: C12345 + term_version: 20.05a + +ciltacabtagene_autoleucel: + common: + description: >- + A preparation of autologous T-lymphocytes that are transduced, ex vivo, with + LCAR-B38M, a lentiviral vector expressing a chimeric antigen receptor (CAR) + containing two bispecific anti-B-cell maturation antigen (BCMA) variable fragments + of llama heavy-chain murine antibodies fused to the signaling domain of 4-1BB + (CD137), with potential immunostimulating and antineoplastic activities. The + antigen-binding region of the CAR is a non-scFv structure targeting two distinct + regions of BCMA. Upon intravenous administration back into the patient, ciltacabtagene + autoleucel are directed to cells expressing BCMA, bind to two different epitopes + on BCMA and induce selective toxicity in BCMA-expressing tumor cells. BCMA, + a tumor-associated antigen (TAA) and a receptor for both a proliferation-inducing + ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor + necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma + cell survival. BCMA is overexpressed on malignant plasma cells. + termDef: + term: >- + Ciltacabtagene Autoleucel + source: NCIt + cde_id: C148498 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148498" + term_id: C148498 + term_version: 20.10d + +cin_iii_nos: + common: + description: >- + Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph + node metastasis. M0: No distant metastasis. (AJCC 6th ed.) + termDef: + term: >- + Stage 0 Cervical Cancer AJCC v6 + source: NCIt + cde_id: C4000 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4000" + term_id: C4000 + term_version: 20.05a + +cin_iii_with_severe_dysplasia: + common: + description: >- + Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph + node metastasis. M0: No distant metastasis. (AJCC 6th ed.) + termDef: + term: >- + Stage 0 Cervical Cancer AJCC v6 + source: NCIt + cde_id: C4000 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4000" + term_id: C4000 + term_version: 20.05a + +cinrebafusp_alfa: + common: + description: >- + A bivalent, bispecific fusion protein comprised of an anti-human epidermal growth + factor receptor (HER2) monoclonal antibody linked to a CD137-targeting anticalin + with potential immunostimulatory and antineoplastic activities. Upon administration + of cinrebafusp alfa, CD137 clustering is promoted by bridging CD137-positive + T-cells with HER2-positive tumor cells, leading to the recruitment of tumor + antigen-specific cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated + lysis of HER2-expressing tumor cells. HER2 plays a key role in tumor cell proliferation + and tumor vascularization. CD137 is a costimulatory immunoreceptor and a member + of the tumor necrosis factor receptor superfamily (TNFRSF). Anticalins are synthetic + antigen-binding proteins derived from lipocalins. Structurally dissimilar to + antibodies, anticalins are able to bind to smaller antigens and exhibit improved + tissue penetration. + termDef: + term: >- + Cinrebafusp Alfa + source: NCIt + cde_id: C142890 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142890" + term_id: C142890 + term_version: 20.10d + +cintirorgon: + common: + description: >- + An orally bioavailable agonist of retinoic acid-related orphan receptor gamma + (RORg), with potential immunomodulatory and antineoplastic activities. Upon + oral administration of cintirorgon, this agent selectively binds to the nuclear + receptor transcription factor RORg, forming a receptor complex that translocates + to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, + proliferation and survival of type 17 T-cells, including Th17 (helper T-cells) + and Tc17 (cytotoxic T-cells). This may increase the expression of co-stimulatory + molecules and decrease the expression of co-inhibitory molecules on T-cells + leading to increased production of cytokines and chemokines by T-cells, decreased + proliferation of regulatory T-cells (Tregs), and abrogation of tumor-induced + immunosuppression. This ultimately induces a T-cell-mediated immune response + against cancer cells and leads to a reduction in tumor cell growth. RORg, the + nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, + plays a key role in immune activation. + termDef: + term: >- + Cintirorgon + source: NCIt + cde_id: C131294 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131294" + term_id: C131294 + term_version: 20.10d + +circulating_tumor_cells: + common: + description: >- + The determination of the amount of circulating tumor cells present in a sample. + termDef: + term: >- + Circulating Tumor Cell Count + source: NCIt + cde_id: C96593 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96593" + term_id: C96593 + term_version: 20.10d + +circumscribed_arachnoidal_cerebellar_sarcoma: + common: + description: >- + A medulloblastoma characterized by the presence of nodular, collagenous areas + which do not contain reticulin, surrounded by hypercellular areas which contain + an intercellular reticulin fiber network. + termDef: + term: >- + Desmoplastic/Nodular Medulloblastoma + source: NCIt + cde_id: C4956 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4956" + term_id: C4956 + term_version: 20.05a + +ck1alphacdk7cdk9_inhibitor_btxa51: + common: + description: >- + The ditosylated salt of A51, an orally bioavailable inhibitor of casein kinase + 1alpha (CK1alpha) and cyclin-dependent kinases 7 and 9 (CDK7 and CDK9), with + potential antineoplastic activity. Upon administration, BTX-A51 binds to and + inhibits the activity of CK1alpha, CDK7, and CDK9. Blocking the phosphorylation + and kinase activity of CK1alpha prevents the enhanced binding of murine double + minute X (MDMX) to p53, the formation of CK1alpha and MDM2 complex, and the + resulting inhibition of p53. This induces p53-mediated cell cycle arrest, slowing + tumor cell proliferation. Blocking the phosphorylation and kinase activity of + CDK7 and CDK9 prevents the positive transcription elongation factor b (PTEFb)-mediated + activation of RNA polymerase II (RNA Pol II) and leads to the inhibition of + gene transcription of various anti-apoptotic proteins. This also induces cell + cycle arrest and apoptosis, slowing tumor cell proliferation. CK1alpha, a serine/threonine + kinase and a leukemic stem cell target, acts as a tumor suppressor in several + cancers through the negative regulation of Wnt/beta-catenin signaling and p53. + It negatively regulates p53 by phosphorylating MDMX, thus enhancing binding + of MDMX to p53, as well as by forming a complex with MDM2. CDK7, a serine/threonine + kinase, plays a role in controlling cell cycle progression, transcriptional + regulation, and promotes the expression of key oncogenes such as c-Myc through + the phosphorylation of RNA Pol II. CDK9, also a serine/threonine kinase, regulates + elongation of transcription through phosphorylation of RNA Pol II at serine + 2 (p-Ser2-RNAPII). It is upregulated in various tumor cell types and plays a + key role in the regulation of RNA Pol II-mediated transcription of anti-apoptotic + proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival. + termDef: + term: >- + CK1alpha/CDK7/CDK9 Inhibitor BTX-A51 + source: NCIt + cde_id: C169027 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C169027" + term_id: C169027 + term_version: 20.10d + +classical_hodgkin_lymphoma_lymphocyte_depletion_nos: + common: + description: >- + A diffuse subtype of classic Hodgkin lymphoma which is rich in Hodgkin and Reed-Sternberg + cells and/or depleted in non-neoplastic lymphocytes. (WHO, 2008) + termDef: + term: >- + Lymphocyte-Depleted Classic Hodgkin Lymphoma + source: NCIt + cde_id: C9283 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9283" + term_id: C9283 + term_version: 20.05a + +classical_hodgkin_lymphoma_lymphocyterich: + common: + description: >- + A subtype of classic Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg + cells and a nodular or less often diffuse cellular background consisting of + small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, + 2008) + termDef: + term: >- + Lymphocyte-Rich Classic Hodgkin Lymphoma + source: NCIt + cde_id: C6913 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6913" + term_id: C6913 + term_version: 20.05a + +classical_hodgkin_lymphoma_mixed_cellularity_nos: + common: + description: >- + A subtype of classic Hodgkin lymphoma with scattered Reed-Sternberg and Hodgkin + cells in a diffuse or vaguely nodular mixed inflammatory background without + nodular sclerosing fibrosis. (WHO, 2008) + termDef: + term: >- + Mixed Cellularity Classic Hodgkin Lymphoma + source: NCIt + cde_id: C3517 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3517" + term_id: C3517 + term_version: 20.05a + +classical_hodgkin_lymphoma_nodular_sclerosis_cellular_phase: + common: + description: >- + A nodular sclerosis Hodgkin lymphoma characterized by the presence of lacunar + cells, nodular growth, and the absence of fibrosis. + termDef: + term: >- + Nodular Sclerosis Classic Hodgkin Lymphoma, Cellular Phase + source: NCIt + cde_id: C67171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67171" + term_id: C67171 + term_version: 20.05a + +classical_hodgkin_lymphoma_nodular_sclerosis_grade_1: + common: + description: >- + Nodular sclerosis Hodgkin lymphoma in which at least 75% of the tumor nodules + contain scattered Reed-Sternberg cells. The background cellular infiltrate is + lymphocytic, mixed, or fibrohistiocytic. + termDef: + term: >- + Grade 1 Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: C7165 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7165" + term_id: C7165 + term_version: 20.05a + +classical_hodgkin_lymphoma_nodular_sclerosis_grade_2: + common: + description: >- + Nodular sclerosis Hodgkin lymphoma in which at least 25% of the tumor nodules + contain increased numbers of Reed-Sternberg cells. + termDef: + term: >- + Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: C7166 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7166" + term_id: C7166 + term_version: 20.05a + +classical_hodgkin_lymphoma_nodular_sclerosis_nos: + common: + description: >- + A subtype of classic Hodgkin lymphoma characterized by collagen bands that surround + at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type + morphology. (WHO, 2008) + termDef: + term: >- + Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: C3518 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3518" + term_id: C3518 + term_version: 20.05a + +clear_cell_adenocarcinoma_mesonephroid: + common: + description: >- + A malignant neoplasm composed of glandular epithelial clear cells. Various + architectural patterns may be seen, including papillary, tubulocystic, and solid. + termDef: + term: >- + Clear Cell Adenocarcinoma + source: NCIt + cde_id: C3766 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3766" + term_id: C3766 + term_version: 20.05a + +clear_cell_adenocarcinoma_nos: + common: + description: >- + A malignant neoplasm composed of glandular epithelial clear cells. Various + architectural patterns may be seen, including papillary, tubulocystic, and solid. + termDef: + term: >- + Clear Cell Adenocarcinoma + source: NCIt + cde_id: C3766 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3766" + term_id: C3766 + term_version: 20.05a + +clear_cell_adenofibroma: + common: + description: >- + A benign or borderline neoplasm characterized by the presence of glandular structures + which contain clear cells and a fibrotic stroma. + termDef: + term: >- + Clear Cell Adenofibroma + source: NCIt + cde_id: C8987 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8987" + term_id: C8987 + term_version: 20.05a + +clear_cell_adenoma: + common: + description: >- + A benign neoplasm composed of glands containing epithelial clear cells. + termDef: + term: >- + Clear Cell Adenoma + source: NCIt + cde_id: C4151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4151" + term_id: C4151 + term_version: 20.05a + +clear_cell_carcinoma: + common: + description: >- + A malignant neoplasm composed of glandular epithelial clear cells. Various + architectural patterns may be seen, including papillary, tubulocystic, and solid. + termDef: + term: >- + Clear Cell Adenocarcinoma + source: NCIt + cde_id: C3766 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3766" + term_id: C3766 + term_version: 20.05a + +clear_cell_chondrosarcoma: + common: + description: >- + A rare, usually low grade chondrosarcoma characterized by the presence of tumor + cells with clear cytoplasm. It usually arises in the epiphyseal ends of long + bones. + termDef: + term: >- + Clear Cell Chondrosarcoma + source: NCIt + cde_id: C6475 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6475" + term_id: C6475 + term_version: 20.05a + +clear_cell_cystadenofibroma: + common: + description: >- + A benign or borderline neoplasm characterized by the presence of cystic glandular + and fibrous tissues and clear cells. + termDef: + term: >- + Clear Cell Cystadenofibroma + source: NCIt + cde_id: C8988 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8988" + term_id: C8988 + term_version: 20.05a + +clear_cell_ependymoma: + common: + description: >- + An ependymoma, often supratentorial in location, characterized by the presence + of ependymal cells with a perinuclear halo. + termDef: + term: >- + Clear Cell Ependymoma + source: NCIt + cde_id: C4714 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4714" + term_id: C4714 + term_version: 20.05a + +clear_cell_glycogenrich_urothelial_carcinoma: + common: + description: >- + An invasive transitional cell carcinoma of the bladder characterized by the + presence of clear cells. + termDef: + term: >- + Infiltrating Bladder Urothelial Carcinoma, Clear Cell Variant + source: NCIt + cde_id: C39827 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39827" + term_id: C39827 + term_version: 20.05a + +clear_cell_hidradenoma: + common: + description: >- + An uncommon benign neoplasm of the sweat glands characterized by the presence + of clear cells. + termDef: + term: >- + Clear Cell Hidradenoma + source: NCIt + cde_id: C7567 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7567" + term_id: C7567 + term_version: 20.05a + +clear_cell_meningioma: + common: + description: >- + A WHO grade II morphologic variant of meningioma characterized by the presence + of clear glycogen-rich polygonal cells. + termDef: + term: >- + Clear Cell Meningioma + source: NCIt + cde_id: C4722 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4722" + term_id: C4722 + term_version: 20.05a + +clear_cell_odontogenic_carcinoma: + common: + description: >- + A usually aggressive malignant neoplasm arising from tooth-forming tissues. + It more often affects older females and more frequently occurs in the mandible. + It is characterized by the presence of malignant epithelial cells with clear + cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases + may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection + with clean margins. + termDef: + term: >- + Clear Cell Odontogenic Carcinoma + source: NCIt + cde_id: C54300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54300" + term_id: C54300 + term_version: 20.05a + +clear_cell_odontogenic_tumor: + common: + description: >- + A usually aggressive malignant neoplasm arising from tooth-forming tissues. + It more often affects older females and more frequently occurs in the mandible. + It is characterized by the presence of malignant epithelial cells with clear + cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases + may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection + with clean margins. + termDef: + term: >- + Clear Cell Odontogenic Carcinoma + source: NCIt + cde_id: C54300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54300" + term_id: C54300 + term_version: 20.05a + +clear_cell_sarcoma_nos: + common: + description: >- + A rare malignant neoplasm with melanocytic differentiation characterized by + the presence of polygonal or spindle shaped clear cells. This sarcoma usually + affects the tendons and aponeuroses and is associated with a poor prognosis + due to recurrences and metastases. + termDef: + term: >- + Clear Cell Sarcoma of Soft Tissue + source: NCIt + cde_id: C3745 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3745" + term_id: C3745 + term_version: 20.05a + +clear_cell_sarcoma_of_kidney: + common: + description: >- + A rare pediatric sarcoma affecting the kidney. It is characterized by the presence + of epithelioid or spindle cells forming cords or nests, separated by fibrovascular + septa. It is associated with internal tandem duplications in the BCOR gene. + It metastasizes to lung, bone, brain and soft tissue. + termDef: + term: >- + Clear Cell Sarcoma of the Kidney + source: NCIt + cde_id: C4264 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4264" + term_id: C4264 + term_version: 20.05a + +clear_cell_tumor_nos: + common: + description: >- + A purely morphologic term that describes a neoplasm in which all or the majority + of the neoplastic cells have a clear cytoplasm, when examined under light microscopy, + using the conventional staining method (H-E). This term does not provide any + information about the nature of the neoplasm (benign or malignant), cell of + origin (e.g. epithelial versus mesenchymal versus hematopoietic), or prognosis. + Further examination using special stains and/or immunohistochemistry is required + to appropriately classify this tumor. + termDef: + term: >- + Clear Cell Neoplasm + source: NCIt + cde_id: C66752 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66752" + term_id: C66752 + term_version: 20.05a + +clip1: + common: + description: >- + This gene plays a role in both endocytosis and mitosis. + termDef: + term: >- + CLIP1 Gene + source: NCIt + cde_id: C84464 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84464" + term_id: C84464 + term_version: 20.10d + +clitoris: + common: + description: >- + The erectile tissue in the vulva. It is composed of the corpora cavernosa and + the glans clitoris. + termDef: + term: >- + Clitoris + source: NCIt + cde_id: C12308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12308" + term_id: C12308 + term_version: 20.05a + +cloacogenic_carcinoma: + common: + description: >- + An anal carcinoma arising from the transitional zone of the anal canal. + termDef: + term: >- + Anal Canal Cloacogenic Carcinoma + source: NCIt + cde_id: C8255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8255" + term_id: C8255 + term_version: 20.05a + +cloacogenic_zone: + common: + description: >- + The middle segment of the anal canal between the colorectal and squamous zones. + termDef: + term: >- + Anal Transitional Zone + source: NCIt + cde_id: C32072 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32072" + term_id: C32072 + term_version: 20.05a + +clonal: + common: + description: >- + A population of cells or organisms that are identifiable by specific, shared + characteristics and presumed to have originated from a single progenitor. + termDef: + term: >- + Monoclonal Cellular Population Present + source: NCIt + cde_id: C96960 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96960" + term_id: C96960 + term_version: 20.10d + +clp1: + common: + description: >- + This gene plays a role in RNA processing. + termDef: + term: >- + CLP1 Gene + source: NCIt + cde_id: C97528 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97528" + term_id: C97528 + term_version: 20.10d + +cltc: + common: + description: >- + This gene plays a role in both the formation of cellular vesicles and receptor-mediated + endocytosis. + termDef: + term: >- + CLTC Gene + source: NCIt + cde_id: C97412 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97412" + term_id: C97412 + term_version: 20.10d + +cltcl1: + common: + description: >- + This gene is involved in both receptor-mediated endocytosis and vesicle formation. + termDef: + term: >- + CLTCL1 Gene + source: NCIt + cde_id: C97415 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97415" + term_id: C97415 + term_version: 20.10d + +cm0_i: + common: + description: >- + A distant metastasis TNM finding indicating that there is no evidence of distant + metastasis clinically or by radiologic studies, but there are small numbers + of cells detected by special studies in the blood and bone marrow, or there + is tiny metastasis (no larger than 0.2 mm) detected in nonregional lymph nodes. + termDef: + term: >- + cM0 (i+) Stage Finding + source: NCIt + cde_id: C95956 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95956" + term_id: C95956 + term_version: 20.05a + +cmet_inhibitor_abn401: + common: + description: >- + An orally bioavailable, highly selective inhibitor of the oncoprotein c-Met + (hepatocyte growth factor receptor; HGFR), with potential antineoplastic activity. + Upon oral administration, ABN401 targets and binds to the c-Met protein, prevents + c-Met phosphorylation and disrupts c-Met-dependent signal transduction pathways. + This may induce cell death in tumor cells overexpressing c-Met protein or expressing + constitutively activated c-Met protein. c-Met protein is overexpressed or mutated + in many tumor cell types and plays key roles in tumor cell proliferation, survival, + invasion, metastasis, and tumor angiogenesis. + termDef: + term: >- + c-Met Inhibitor ABN401 + source: NCIt + cde_id: C170765 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170765" + term_id: C170765 + term_version: 20.10d + +cmet_inhibitor_gsthg161: + common: + description: >- + An orally bioavailable, selective inhibitor of the oncoprotein c-Met (hepatocyte + growth factor receptor; HGFR), with potential antineoplastic activity. Upon + oral administration, c-Met inhibitor GST-HG161 targets and binds to c-Met protein, + thereby disrupting c-Met-dependent signal transduction pathways. This may induce + cell death in tumor cells overexpressing c-Met protein. c-Met protein is overexpressed + or mutated in many tumor cell types and plays key roles in tumor cell proliferation, + survival, invasion, metastasis, and tumor angiogenesis. + termDef: + term: >- + c-Met Inhibitor GST-HG161 + source: NCIt + cde_id: C175449 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175449" + term_id: C175449 + term_version: 20.10d + +cnbd1: + common: + description: >- + This gene is involved in cyclic nucleotide binding. + termDef: + term: >- + CNBD1 Gene + source: NCIt + cde_id: C143056 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143056" + term_id: C143056 + term_version: 20.10d + +cnbp: + common: + description: >- + This gene is involved in sterol-mediated transcription. + termDef: + term: >- + CNBP Gene + source: NCIt + cde_id: C97888 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97888" + term_id: C97888 + term_version: 20.10d + +cnot3: + common: + description: >- + This gene is involved in mRNA degradation, miRNA-mediated repression, translational + regulation and general transcription regulation. + termDef: + term: >- + CNOT3 Gene + source: NCIt + cde_id: C107658 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107658" + term_id: C107658 + term_version: 20.10d + +cns_cancer: + common: + description: >- + A primary or metastatic malignant neoplasm involving the brain or spinal cord. + Representative examples include anaplastic astrocytoma, glioblastoma, anaplastic + (malignant) meningioma, lymphoma, and metastatic carcinoma from another anatomic + site. + termDef: + term: >- + Malignant Central Nervous System Neoplasm + source: NCIt + cde_id: C4627 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4627" + term_id: C4627 + term_version: 19.12e + +cns_embryonal_tumor_with_rhabdoid_features: + common: + description: >- + A central nervous system embryonal neoplasm characterized by the presence of + histological features consistent with atypical teratoid/rhabdoid tumor and absence + of mutations of the INI1 gene or SMARCA4 (BRG1) gene. + termDef: + term: >- + Central Nervous System Embryonal Tumor with Rhabdoid Features + source: NCIt + cde_id: C129501 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129501" + term_id: C129501 + term_version: 20.05a + +cntnap2: + common: + description: >- + This gene may be involved in axonal structure. + termDef: + term: >- + CNTNAP2 Gene + source: NCIt + cde_id: C73461 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73461" + term_id: C73461 + term_version: 20.10d + +cntrl: + common: + description: >- + This gene plays a role in cell cycle progression. + termDef: + term: >- + CNTRL Gene + source: NCIt + cde_id: C97891 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97891" + term_id: C97891 + term_version: 20.10d + +coal_smoke_nos: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when coal is rapidly oxidized via combustion. + termDef: + term: >- + Coal Smoke Exposure + source: NCIt + cde_id: C164060 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164060" + term_id: C164060 + term_version: 19.12e + +cobolimab: + common: + description: >- + A monoclonal antibody against the inhibitory T-cell receptor, T-cell immunoglobulin + and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular + receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic + activities. Upon administration, cobolimab binds to TIM-3 expressed on certain + T-cells, including tumor infiltrating lymphocytes (TILs). This abrogates T-cell + inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic + T-cell-mediated tumor cell lysis, which results in a reduction in tumor growth. + TIM-3, a transmembrane protein and immune checkpoint receptor, is associated + with tumor-mediated immune suppression. + termDef: + term: >- + Cobolimab + source: NCIt + cde_id: C128627 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128627" + term_id: C128627 + term_version: 20.10d + +coding_sequence_variant: + common: + description: >- + A change in the nucleotide sequence of an exon in a gene. + termDef: + term: >- + Exon Mutation + source: NCIt + cde_id: C148639 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148639" + term_id: C148639 + term_version: 20.10d + +codman_tumor: + common: + description: >- + A benign, chondroid-producing, well-circumscribed, lytic neoplasm usually arising + from the epiphysis of long bones. It is characterized by the presence of chondroblasts, + osteoclast-like giant cells, chondroid formation, calcification, and mitotic + activity. In aggressive cases, there is rearrangement of the 8q21 chromosome + band. It occurs most frequently in children and young adults and rarely metastasizes. + termDef: + term: >- + Chondroblastoma + source: NCIt + cde_id: C2945 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2945" + term_id: C2945 + term_version: 20.05a + +cofetuzumab_pelidotin: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody + against human inactive tyrosine-protein kinase 7 (PTK7) linked, via a cleavable + valine-citrulline linker, to an analog of the auristatin microtubule inhibitor + dolastatin 10, auristatin-0101, with potential antineoplastic activity. Upon + administration, cofetuzumab pelidotin targets and binds to PTK7 expressed on + tumor cells. Upon binding, internalization and cleavage, auristatin-0101 binds + to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and + apoptosis of PTK7-expressing tumor cells. PTK7, a tumor-associated antigen (TAA), + is overexpressed on a variety of cancer cells. + termDef: + term: >- + Cofetuzumab Pelidotin + source: NCIt + cde_id: C123828 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123828" + term_id: C123828 + term_version: 20.10d + +col1a1: + common: + description: >- + This gene plays an important structural role in cartilage and mutations in the + gene are associated with osteogenesis imperfecta. + termDef: + term: >- + COL1A1 Gene + source: NCIt + cde_id: C29949 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C29949" + term_id: C29949 + term_version: 20.10d + +col2a1: + common: + description: >- + This gene plays a role in both skeletal development and cartilage structure. + termDef: + term: >- + COL2A1 Gene + source: NCIt + cde_id: C75315 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75315" + term_id: C75315 + term_version: 20.10d + +col3a1: + common: + description: >- + This gene plays a role in collagen formation in connective tissues. + termDef: + term: >- + COL3A1 Gene + source: NCIt + cde_id: C143052 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143052" + term_id: C143052 + term_version: 20.10d + +collecting_duct_carcinoma: + common: + description: >- + Also known as collecting duct carcinoma, this is a rare type of renal carcinoma. + It arises from the collecting ducts of the renal medulla, and most authors suggest + that this is an aggressive tumor. + termDef: + term: >- + Collecting Duct Carcinoma + source: NCIt + cde_id: C6194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6194" + term_id: C6194 + term_version: 20.05a + +colloid_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +colloid_adenoma: + common: + description: >- + A thyroid gland adenoma composed of large size follicles. + termDef: + term: >- + Thyroid Gland Macrofollicular Adenoma + source: NCIt + cde_id: C4161 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4161" + term_id: C4161 + term_version: 20.05a + +colloid_carcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +colombia: + common: + description: >- + A country in northern South America, bordering the Caribbean Sea and the North + Pacific Ocean, between Ecuador and Venezuela. + termDef: + term: >- + Colombia + source: NCIt + cde_id: C16449 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16449" + term_id: C16449 + term_version: 19.12e + +colon: + common: + description: >- + The part of the large intestine measured from the cecum to the rectum consisting + of ascending, transverse, descending and sigmoid portions. The purpose of the + colon is to remove water from digested food prior to excretion. + termDef: + term: >- + Colon + source: NCIt + cde_id: C12382 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12382" + term_id: C12382 + term_version: 20.05a + +colon_nos: + common: + description: >- + The part of the large intestine measured from the cecum to the rectum consisting + of ascending, transverse, descending and sigmoid portions. The purpose of the + colon is to remove water from digested food prior to excretion. + termDef: + term: >- + Colon + source: NCIt + cde_id: C12382 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12382" + term_id: C12382 + term_version: 20.05a + +colorectal_cancer: + common: + description: >- + A malignant epithelial neoplasm that arises from the colon or rectum and invades + through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. + termDef: + term: >- + Colorectal Carcinoma + source: NCIt + cde_id: C2955 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2955" + term_id: C2955 + term_version: 19.12e + +coltuximab_ravtansine: + common: + description: >- + An immunoconjugate consisting of an anti-CD19 monoclonal antibody conjugated + to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), + with potential antineoplastic activity. Coltuximab ravtansine targets the cell + surface antigen CD19, found on a number of B-cell-derived cancers. Upon antibody/antigen + binding and internalization, the immunoconjugate releases DM4, which binds to + tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in + inhibition of cell division and cell growth of CD19-expressing tumor cells. + termDef: + term: >- + Coltuximab Ravtansine + source: NCIt + cde_id: C71009 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71009" + term_id: C71009 + term_version: 20.10d + +combined_carcinoid_and_adenocarcinoma: + common: + description: >- + A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells + with morphologic and immunohistochemical characteristics of carcinoid tumor + and malignant glandular cells. + termDef: + term: >- + Combined Carcinoid and Adenocarcinoma + source: NCIt + cde_id: C4139 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4139" + term_id: C4139 + term_version: 20.05a + +combined_hepatocellular_carcinoma_and_cholangiocarcinoma: + common: + description: >- + A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma + that are intimately admixed. This tumor should be distinguished from separate + hepatocellular carcinoma and cholangiocarcinoma arising in the same liver. The + prognosis of this tumor is poor. + termDef: + term: >- + Combined Hepatocellular Carcinoma and Cholangiocarcinoma + source: NCIt + cde_id: C3828 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3828" + term_id: C3828 + term_version: 20.05a + +combined_large_cell_neuroendocrine_carcinoma: + common: + description: >- + A subtype of large cell neuroendocrine lung carcinoma characterized by the presence + of large neuroendocrine cells in combination with adenocarcinoma, squamous cell + carcinoma, giant cell carcinoma and/ or spindle cell carcinoma. + termDef: + term: >- + Combined Lung Large Cell Neuroendocrine Carcinoma + source: NCIt + cde_id: C7267 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7267" + term_id: C7267 + term_version: 20.05a + +combined_small_cell_carcinoma: + common: + description: >- + A morphologic variant of small cell lung carcinoma in combination with a non-small + cell carcinoma. + termDef: + term: >- + Combined Lung Small Cell Carcinoma + source: NCIt + cde_id: C9137 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9137" + term_id: C9137 + term_version: 20.05a + +combined_small_celladenocarcinoma: + common: + description: >- + A lung carcinoma characterized by a combination of small cell carcinoma and + adenocarcinoma. + termDef: + term: >- + Combined Lung Small Cell Carcinoma and Lung Adenocarcinoma + source: NCIt + cde_id: C9379 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9379" + term_id: C9379 + term_version: 20.05a + +combined_small_cellsquamous_cell_carcinoma: + common: + description: >- + A morphologic variant of small cell lung carcinoma in combination with a non-small + cell carcinoma. + termDef: + term: >- + Combined Lung Small Cell Carcinoma + source: NCIt + cde_id: C9137 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9137" + term_id: C9137 + term_version: 20.05a + +combinedmixed_carcinoid_and_adenocarcinoma: + common: + description: >- + A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells + with morphologic and immunohistochemical characteristics of carcinoid tumor + and malignant glandular cells. + termDef: + term: >- + Combined Carcinoid and Adenocarcinoma + source: NCIt + cde_id: C4139 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4139" + term_id: C4139 + term_version: 20.05a + +comedocarcinoma_nos: + common: + description: >- + A high grade carcinoma characterized by the presence of comedo-type tumor cell + necrosis in which the necrotic areas are surrounded by a solid proliferation + of malignant pleomorphic cells. + termDef: + term: >- + Comedocarcinoma + source: NCIt + cde_id: C4188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4188" + term_id: C4188 + term_version: 20.05a + +commensal_bacterial_strain_formulation_ve800: + common: + description: >- + An orally bioavailable formulation composed of eleven alive, distinct nonpathogenic, + nontoxigenic, human commensal bacterial strains, isolated from healthy human + donor feces, with potential immunostimulating and antineoplastic activities. + Upon administration of the commensal bacterial strain formulation VE800, the + bacterial strains induce an interferon-gamma (IFN-g)-producing CD8-positive + T-cell-mediated immune response in the intestines. This may activate an IFN-g-expressing + CD8+ T-cell -mediated anti-cancer immune response and may eradicate tumor cells. + termDef: + term: >- + Commensal Bacterial Strain Formulation VE800 + source: NCIt + cde_id: C167393 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167393" + term_id: C167393 + term_version: 20.10d + +commissure_of_lip: + common: + description: >- + The junction of the upper and lower lips at the corner of the mouth. + termDef: + term: >- + Commissure of the Lip + source: NCIt + cde_id: C12227 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12227" + term_id: C12227 + term_version: 20.05a + +common_all: + common: + description: >- + Common Acute Lymphoblastic Leukemia + termDef: + term: >- + Common Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27797 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27797" + term_id: C27797 + term_version: 20.05a + +common_precursor_b_all: + common: + description: >- + Common Acute Lymphoblastic Leukemia + termDef: + term: >- + Common Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27797 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27797" + term_id: C27797 + term_version: 20.05a + +comoros: + common: + description: >- + A group of islands in the Mozambique Channel, about two-thirds of the way between + northern Madagascar and northern Mozambique, northwest of Mayotte. + termDef: + term: >- + Comoros + source: NCIt + cde_id: C16458 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16458" + term_id: C16458 + term_version: 19.12e + +comparative_genomic_hybridization: + common: + description: >- + Comparative genomic hybridization (CGH) is a technique that allows the detection + of losses and gains in DNA copy number across the entire genome without prior + knowledge of specific chromosomal abnormalities. Comparative genomic hybridization + utilizes the hybridization of differentially labeled tumor and reference DNA + to generate a map of DNA copy number changes in tumor genomes. Comparative genomic + hybridization is an ideal tool for analyzing chromosomal imbalances in archived + tumor material and for examining possible correlations between these findings + and tumor phenotypes. (from Ried et al. J Mol Med 1997 75:801-14) + termDef: + term: >- + Comparative Genomic Hybridization + source: NCIt + cde_id: C18084 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18084" + term_id: C18084 + term_version: 20.10d + +complete_hydatidiform_mole: + common: + description: >- + A gestational trophoblastic disorder in which there is no embryo or normal placental + tissue and the chorionic villi are hydropic. + termDef: + term: >- + Complete Hydatidiform Mole + source: NCIt + cde_id: C4871 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4871" + term_id: C4871 + term_version: 20.05a + +complex_odontoma: + common: + description: >- + A benign, slow growing, and painless hamartomatous tumor occurring in tooth-bearing + areas of the jaws. It is one of the most common odontogenic tumors and it usually + affects children, adolescents, and young adults. It is characterized by the + presence of enamel and dentin and the absence of tooth-like structures. It is + treated with local excision. If it is incompletely removed, it may recur. + termDef: + term: >- + Complex Odontoma + source: NCIt + cde_id: C4309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4309" + term_id: C4309 + term_version: 20.05a + +composite_carcinoid: + common: + description: >- + A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells + with morphologic and immunohistochemical characteristics of carcinoid tumor + and malignant glandular cells. + termDef: + term: >- + Combined Carcinoid and Adenocarcinoma + source: NCIt + cde_id: C4139 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4139" + term_id: C4139 + term_version: 20.05a + +compound_nevus: + common: + description: >- + A nevus composed of neoplastic melanocytes that infiltrate both the epidermis + and the dermis. + termDef: + term: >- + Compound Nevus + source: NCIt + cde_id: C3901 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3901" + term_id: C3901 + term_version: 20.05a + +compound_odontoma: + common: + description: >- + A benign, slow growing, and painless hamartomatous tumor occurring in tooth-bearing + areas of the jaws. It usually affects children and adolescents. It is characterized + by the presence of tooth-like structures. Treatment consists of local excision. + Recurrences have not been reported. + termDef: + term: >- + Compound Odontoma + source: NCIt + cde_id: C3711 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3711" + term_id: C3711 + term_version: 20.05a + +condylomatous_carcinoma: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary growth + pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most + commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, + esophagus, anus, vagina, vulva, and the plantar region of the foot. + termDef: + term: >- + Verrucous Carcinoma + source: NCIt + cde_id: C3781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3781" + term_id: C3781 + term_version: 20.05a + +congenital_fibrosarcoma: + common: + description: >- + A fibrosarcoma that occurs in infants. It shares identical morphologic features + with adult fibrosarcoma but carries the t(12;15)(p13;q25) translocation that + results in ETV6-NTRK3 gene fusion. It usually affects the superficial and deep + soft tissues of the extremities. The prognosis is generally much more favorable + than for adult fibrosarcoma, and it rarely metastasizes. + termDef: + term: >- + Infantile Fibrosarcoma + source: NCIt + cde_id: C4244 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4244" + term_id: C4244 + term_version: 20.05a + +congo: + common: + description: >- + A country in western Africa, bordering the South Atlantic Ocean, between Gabon + and the Democratic Republic of the Congo. + termDef: + term: >- + Congo + source: NCIt + cde_id: C16467 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16467" + term_id: C16467 + term_version: 19.12e + +conjunctiva: + common: + description: >- + A thin, transparent tissue divided into the palpebral conjunctiva (covering + the inner side of the eye lid) and the bulbar conjunctiva (covering the eyeball). + termDef: + term: >- + Conjunctiva + source: NCIt + cde_id: C12341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12341" + term_id: C12341 + term_version: 20.05a + +connective_tissue: + common: + description: >- + Supporting tissue that surrounds other tissues and organs. Specialized connective + tissue includes bone, cartilage, blood, and fat. + termDef: + term: >- + Connective Tissue + source: NCIt + cde_id: C12374 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12374" + term_id: C12374 + term_version: 20.10d + +conventional_central_osteosarcoma: + common: + description: >- + A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. + The tumor arises from the medullary portion of the bone. It affects the long + bones and most commonly, the distal femur, proximal tibia, and proximal humerus. + Pain with or without a palpable mass is the most common clinical presentation. + It usually has an aggressive growth and may metastasize through the hematogenous + route. The lung is the most frequent site of metastasis. + termDef: + term: >- + Conventional Osteosarcoma + source: NCIt + cde_id: C35870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35870" + term_id: C35870 + term_version: 20.05a + +conversion: + common: + description: >- + A rearrangement where nonreciprocal transfer of genetic information between + two sites in the genome lead to the deletion of one sequence and the duplication + of the transferred sequence. + termDef: + term: >- + Conversion Mutation + source: NCIt + cde_id: C165230 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165230" + term_id: C165230 + term_version: 20.10d + +cook_islands: + common: + description: >- + A group of islands in the South Pacific Ocean, east of Australia, between Tonga + and French Polynesia. + termDef: + term: >- + Cook Islands + source: NCIt + cde_id: C16469 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16469" + term_id: C16469 + term_version: 19.12e + +cookingrelated_smoke_nos: + common: + description: >- + Environmental, occupational or consumer-based exposure to vaporized materials + produced when food products are being cooked. + termDef: + term: >- + Cooking-Related Smoke Exposure + source: NCIt + cde_id: C164061 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164061" + term_id: C164061 + term_version: 19.12e + +copper_cu_67_tyr3octreotate: + common: + description: >- + A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate + (TATE) conjugated with the bifunctional chelator 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic + acid (MeCOSar) and radiolabeled with the beta-emitting radioisotope copper Cu + 67, with potential antineoplastic activity. Upon administration, copper Cu 67 + Tyr3-octreotate binds to somatostatin receptors (SSTRs), with high affinity + to type 2 SSTR, present on the cell membranes of many types of neuroendocrine + tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically + delivers a cytotoxic dose of beta radiation to SSTR-positive cells. TATE is + an octreotide derivative in which phenylalanine at position 3 is substituted + by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have + been shown to be present in large numbers on NET and their metastases, while + most other normal tissues express low levels of SSTRs. + termDef: + term: >- + Copper Cu 67 Tyr3-octreotate + source: NCIt + cde_id: C171370 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171370" + term_id: C171370 + term_version: 20.10d + +copy_number_reported: + common: + description: >- + The number of molecules of a particular type on or in a cell or part of a cell. + Usually applied to specific genes or to plasmids within a bacterium. + termDef: + term: >- + Copy Number + source: NCIt + cde_id: C49142 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49142" + term_id: C49142 + term_version: 20.10d + +cord_blood_derived_car_tcells: + common: + description: >- + A preparation of umbilical cord blood (CB)-derived T-lymphocytes that are genetically + engineered to express a chimeric antigen receptor (CAR) that targets an as of + yet unidentified tumor-associated antigen (TAA), with potential immunomodulatory + and antineoplastic activities. Upon administration of the cord blood derived + CAR T-cells, the T-cells target, bind to and induce selective cytotoxicity in + tumor cells expressing the TAA. + termDef: + term: >- + Cord Blood Derived CAR T-Cells + source: NCIt + cde_id: C172058 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172058" + term_id: C172058 + term_version: 20.10d + +core_biopsy: + common: + description: >- + The removal of a tissue sample using a needle with a relatively large diameter, + for microscopic examination. + termDef: + term: >- + Core Biopsy + source: NCIt + cde_id: C15680 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15680" + term_id: C15680 + term_version: 20.05a + +cornea_nos: + common: + description: >- + A dome-shaped, transparent, avascular tissue covering the front of the eye. + It is composed of five layers: squamous epithelium, Bowman's membrane, stroma, + Descemet's membrane, and endothelium. Refraction of light contributing to eye's + focusing ability is its characteristic function. It contains unmyelinated nerve + endings which are responsible for the high sensitivity of the tissue. + termDef: + term: >- + Cornea + source: NCIt + cde_id: C12342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12342" + term_id: C12342 + term_version: 20.05a + +corpus_uteri: + common: + description: >- + The Corpus uteri, or body of uterus, is the part of the uterus above the isthmus, + comprising about two thirds of the non-pregnant organ. + termDef: + term: >- + Corpus Uteri + source: NCIt + cde_id: C12316 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12316" + term_id: C12316 + term_version: 20.05a + +cortex_of_adrenal_gland: + common: + description: >- + The outer region of the adrenal gland consisting of the zona glomerulosa, the + zona fasciculata, and the zona reticularis. The adrenal cortex produces and + secretes mineralocorticoids, glucocorticoids, and adrenal androgens. + termDef: + term: >- + Adrenal Cortex + source: NCIt + cde_id: C12396 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12396" + term_id: C12396 + term_version: 20.05a + +cortical_t_all: + common: + description: >- + Mature T-ALL + termDef: + term: >- + Mature T-ALL + source: NCIt + cde_id: C27820 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27820" + term_id: C27820 + term_version: 20.05a + +cosibelimab: + common: + description: >- + An immunoglobulin G1 (IgG1), human monoclonal antibody directed against the + immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of + differentiation 274; CD274), with potential immune checkpoint inhibitory and + antineoplastic activities. Upon administration, cosibelimab specifically targets + and binds to PD-L1, blocking its binding to and activation of its receptor programmed + cell death protein 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses + T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic + T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing + tumor cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding + to PD-1 on T-cells suppresses the immune system and results in immune evasion. + PD-1, a transmembrane protein belonging to the immunoglobulin superfamily expressed + on activated T-cells, is a negative regulator of the immune system that limits + the expansion and survival of CD8-positive T-cells. + termDef: + term: >- + Cosibelimab + source: NCIt + cde_id: C151947 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C151947" + term_id: C151947 + term_version: 20.10d + +costa_rica: + common: + description: >- + A country in Central America, bordering both the Caribbean Sea and the North + Pacific Ocean, between Nicaragua and Panama. + termDef: + term: >- + Costa Rica + source: NCIt + cde_id: C16470 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16470" + term_id: C16470 + term_version: 19.12e + +cote_divoire: + common: + description: >- + A country in western Africa, bordering the North Atlantic Ocean, between Ghana + and Liberia. + termDef: + term: >- + Cote d'Ivoire + source: NCIt + cde_id: C16762 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16762" + term_id: C16762 + term_version: 19.12e + +cousin: + common: + description: >- + A child of your aunt or uncle or their descendents. + termDef: + term: >- + Cousin + source: NCIt + cde_id: C71410 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71410" + term_id: C71410 + term_version: 19.12e + +cox6c: + common: + description: >- + This gene is involved in mitochondrial respiration. + termDef: + term: >- + COX6C Gene + source: NCIt + cde_id: C24308 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24308" + term_id: C24308 + term_version: 20.10d + +coxsackievirus_v937: + common: + description: >- + A preparation of naturally occurring, oncolytic enterovirus, with potential + antineoplastic activity. Upon administration, coxsackievirus V937 targets and + binds to intracellular adhesion molecule 1 (ICAM-1) and decay acceleration factor + (DAF), both cell surface molecules that are overexpressed on certain malignant + cells. After entering the cells, coxsackievirus V937 replicates in these cancer + cells, thereby causing cancer cell lysis. This results in a reduction of tumor + cell growth. + termDef: + term: >- + Coxsackievirus V937 + source: NCIt + cde_id: C61493 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61493" + term_id: C61493 + term_version: 20.10d + +cpdclinical_progression: + common: + description: >- + The worsening of a disease over time. + termDef: + term: >- + Disease Progression + source: NCIt + cde_id: C17747 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17747" + term_id: C17747 + term_version: 20.05a + +cpnet: + common: + description: >- + A term that refers to central nervous system embryonal tumors which are not + fully characterized. This category includes tumors previously designated as + central nervous system primitive neuroectodermal tumors. + termDef: + term: >- + Central Nervous System Embryonal Tumor, Not Otherwise Specified + source: NCIt + cde_id: C5398 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5398" + term_id: C5398 + term_version: 20.05a + +cranial_nerve_nos: + common: + description: >- + Any of the 12 paired nerves that originate in the brain stem. + termDef: + term: >- + Cranial Nerve + source: NCIt + cde_id: C12700 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12700" + term_id: C12700 + term_version: 20.05a + +craniopharyngeal_duct: + common: + description: >- + The slender tubular part of the hypophysial diverticulum; the stalk of Rathke's + pocket. + termDef: + term: >- + Craniopharyngeal Duct + source: NCIt + cde_id: C12357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12357" + term_id: C12357 + term_version: 20.05a + +craniopharyngioma: + common: + description: >- + A benign, partly cystic, epithelial tumor of the sellar region, presumably derived + from Rathke pouch epithelium. It affects mainly children and young adults. There + are two clinicopathological forms: adamantinomatous craniopharyngioma and papillary + craniopharyngioma. The most significant factor associated with recurrence is + the extent of surgical resection, with lesions greater than 5 cm in diameter + carrying a markedly worse prognosis. (Adapted from WHO) + termDef: + term: >- + Craniopharyngioma + source: NCIt + cde_id: C2964 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2964" + term_id: C2964 + term_version: 20.05a + +craniopharyngioma_adamantinomatous: + common: + description: >- + A craniopharyngioma consisting of broad strands, cords and bridges of a multistratified + squamous epithelium with peripheral palisading of nuclei. Diagnostic features + include nodules of compact 'wet' keratin and dystrophic calcification. (Adapted + from WHO) + termDef: + term: >- + Adamantinomatous Craniopharyngioma + source: NCIt + cde_id: C4726 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4726" + term_id: C4726 + term_version: 20.05a + +craniopharyngioma_papillary: + common: + description: >- + A craniopharyngioma composed of sheets of squamous epithelium which separate + to form pseudopapillae. This variant typically lacks nuclear palisading, wet + keratin, calcification, and cholesterol deposits. Clinically, endocrine deficiencies + are more often associated with papillary craniopharyngioma than with the adamantinomatous + type. (Adapted from WHO) + termDef: + term: >- + Papillary Craniopharyngioma + source: NCIt + cde_id: C4725 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4725" + term_id: C4725 + term_version: 20.05a + +crcomplete_response: + common: + description: >- + The disappearance of all signs of cancer in response to treatment. + termDef: + term: >- + Complete Remission + source: NCIt + cde_id: C4870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4870" + term_id: C4870 + term_version: 20.05a + +creactive_protein: + common: + description: >- + A quantitative measurement of the amount of C-reactive protein present in a + sample. + termDef: + term: >- + C-Reactive Protein Measurement + source: NCIt + cde_id: C64548 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64548" + term_id: C64548 + term_version: 20.10d + +creatinine: + common: + description: >- + A quantitative measurement of the amount of creatinine present in a sample. + termDef: + term: >- + Creatinine Measurement + source: NCIt + cde_id: C64547 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64547" + term_id: C64547 + term_version: 20.10d + +creb1: + common: + description: >- + This gene is involved in transcriptional regulation and its activity is modulated + in response to hormonal stimulation from the cAMP pathway. + termDef: + term: >- + CREB1 Gene + source: NCIt + cde_id: C38536 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38536" + term_id: C38536 + term_version: 20.10d + +creb3l1: + common: + description: >- + This gene plays a role in transcriptional regulation in response to cellular + stress. + termDef: + term: >- + CREB3L1 Gene + source: NCIt + cde_id: C95477 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95477" + term_id: C95477 + term_version: 20.10d + +creb3l2: + common: + description: >- + This gene is involved in the response to cellular stress. + termDef: + term: >- + CREB3L2 Gene + source: NCIt + cde_id: C95480 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95480" + term_id: C95480 + term_version: 20.10d + +crebbp: + common: + description: >- + This gene plays a role in transcriptional regulation and in NF-kappa B signal + transduction. + termDef: + term: >- + CREBBP Gene + source: NCIt + cde_id: C26568 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26568" + term_id: C26568 + term_version: 20.10d + +cribiform: + common: + description: >- + A morphologic finding indicating the presence of sheets of malignant epithelial + cells punctuated by gland-like spaces in a tissue sample. + termDef: + term: >- + Cribriform Pattern + source: NCIt + cde_id: C35920 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35920" + term_id: C35920 + term_version: 20.10d + +cribriform_carcinoma_nos: + common: + description: >- + A carcinoma characterized by the presence of a cribriform architectural pattern. + Representative examples include the intraductal cribriform breast carcinoma + and invasive cribriform breast carcinoma. + termDef: + term: >- + Cribriform Carcinoma + source: NCIt + cde_id: C3680 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3680" + term_id: C3680 + term_version: 20.05a + +crlf2: + common: + description: >- + This gene is involved in cytokine binding and signaling. + termDef: + term: >- + CRLF2 Gene + source: NCIt + cde_id: C97430 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97430" + term_id: C97430 + term_version: 20.10d + +crnkl1: + common: + description: >- + This gene is involved in RNA binding and pre-mRNA splicing. + termDef: + term: >- + CRNKL1 Gene + source: NCIt + cde_id: C143049 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143049" + term_id: C143049 + term_version: 20.10d + +croatia: + common: + description: >- + A country in southeastern Europe, bordering the Adriatic Sea, between Bosnia + and Herzegovina and Slovenia. + termDef: + term: >- + Croatia + source: NCIt + cde_id: C16474 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16474" + term_id: C16474 + term_version: 19.12e + +crtc1: + common: + description: >- + This gene plays a role in the positive regulation of transcription. + termDef: + term: >- + CRTC1 Gene + source: NCIt + cde_id: C95449 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95449" + term_id: C95449 + term_version: 20.10d + +crtc3: + common: + description: >- + This gene is involved in transcriptional regulation. + termDef: + term: >- + CRTC3 Gene + source: NCIt + cde_id: C95276 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95276" + term_id: C95276 + term_version: 20.10d + +crucomplete_response_unconfirmed: + common: + description: >- + An indication that a finding of complete response to treatment has not been + confirmed. + termDef: + term: >- + Complete Response Unconfirmed + source: NCIt + cde_id: C165198 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165198" + term_id: C165198 + term_version: 20.05a + +csf1r: + common: + description: >- + This gene is essential for the regulation of the production, differentiation, + and function of macrophages. + termDef: + term: >- + CSF1R Gene + source: NCIt + cde_id: C18516 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18516" + term_id: C18516 + term_version: 20.10d + +csf1r_inhibitor_absk021: + common: + description: >- + An orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF1R; + CSF-1R; CD115; M-CSFR), with potential immunomodulatory and antineoplastic activities. + Upon administration, CSF1R inhibitor ABSK021 targets and binds to CSF1R, thereby + blocking CSF1R activation and CSF1R-mediated signaling. This inhibits the activities + of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells + (MDSCs), and prevents immune suppression in the tumor microenvironment (TME). + This enhances antitumor T-cell immune responses and inhibits the proliferation + of tumor cells. CSF1R, also known as macrophage colony-stimulating factor receptor + (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface receptor + that plays major roles in tumor cell proliferation and metastasis. + termDef: + term: >- + CSF1R Inhibitor ABSK021 + source: NCIt + cde_id: C173651 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173651" + term_id: C173651 + term_version: 20.10d + +csf3r: + common: + description: >- + This gene plays an inhibitory role in cell survival and proliferation. + termDef: + term: >- + CSF3R Gene + source: NCIt + cde_id: C24313 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24313" + term_id: C24313 + term_version: 20.10d + +csmd3: + common: + description: >- + This gene plays a role in neuronal development. + termDef: + term: >- + CSMD3 Gene + source: NCIt + cde_id: C143042 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143042" + term_id: C143042 + term_version: 20.10d + +ctcf: + common: + description: >- + This gene is involved in epigenetic control of gene expression. + termDef: + term: >- + CTCF Gene + source: NCIt + cde_id: C73679 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73679" + term_id: C73679 + term_version: 20.10d + +ctnna2: + common: + description: >- + This gene is involved in cell-cell adhesion and cellular differentiation in + the nervous system. + termDef: + term: >- + CTNNA2 Gene + source: NCIt + cde_id: C143115 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143115" + term_id: C143115 + term_version: 20.10d + +ctnnb1: + common: + description: >- + This gene is involved in signal transduction and regulation of transcription. + termDef: + term: >- + CTNNB1 Gene + source: NCIt + cde_id: C20987 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20987" + term_id: C20987 + term_version: 20.10d + +ctnnd1: + common: + description: >- + This gene plays a role in signal transduction. + termDef: + term: >- + CTNND1 Gene + source: NCIt + cde_id: C79770 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C79770" + term_id: C79770 + term_version: 20.10d + +ctnnd2: + common: + description: >- + This gene is involved in the regulation of both transcription and signal transduction. + termDef: + term: >- + CTNND2 Gene + source: NCIt + cde_id: C82941 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82941" + term_id: C82941 + term_version: 20.10d + +cuba: + common: + description: >- + An island between the Caribbean Sea and the North Atlantic Ocean, 150 km south + of Key West, Florida. + termDef: + term: >- + Cuba + source: NCIt + cde_id: C16477 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16477" + term_id: C16477 + term_version: 19.12e + +cul3: + common: + description: >- + This gene plays a role in protein degradation and cell cycle arrest. + termDef: + term: >- + CUL3 Gene + source: NCIt + cde_id: C24323 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24323" + term_id: C24323 + term_version: 20.10d + +curacao: + common: + description: >- + An island in the Caribbean Sea, north of Venezuela and east of Aruba, a constituent + country of the Kingdom of the Netherlands. + termDef: + term: >- + Curacao + source: NCIt + cde_id: C101225 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101225" + term_id: C101225 + term_version: 19.12e + +cutaneous_histiocytoma_nos: + common: + description: >- + A solitary, slowly growing, nodular tumor most often affecting the extremities. + It is composed of fibrous and histiocytic cells which infiltrate the dermis + and occasionally the underlying subcutaneous tissue. Usually local excision + is curative. Recurrences are reported only in a small minority of cases. + termDef: + term: >- + Skin Fibrous Histiocytoma + source: NCIt + cde_id: C6801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6801" + term_id: C6801 + term_version: 20.05a + +cutaneous_lymphoma_nos: + common: + description: >- + Primary Cutaneous Lymphoma + termDef: + term: >- + Primary Cutaneous Lymphoma + source: NCIt + cde_id: C7162 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7162" + term_id: C7162 + term_version: 20.05a + +cutaneous_mastocytosis: + common: + description: >- + A form of mastocytosis characterized by mast cell infiltration of the skin. (WHO, + 2001) + termDef: + term: >- + Cutaneous Mastocytosis + source: NCIt + cde_id: C7137 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7137" + term_id: C7137 + term_version: 20.05a + +cutaneous_tcell_lymphoma_nos: + common: + description: >- + A T-cell non-Hodgkin lymphoma arising from the skin. Representative examples + include mycosis fungoides and primary cutaneous anaplastic large cell lymphoma. + termDef: + term: >- + Primary Cutaneous T-Cell Non-Hodgkin Lymphoma + source: NCIt + cde_id: C3467 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3467" + term_id: C3467 + term_version: 20.05a + +cux1: + common: + description: >- + This gene is involved in both transcriptional regulation and Golgi vesicle transport. + termDef: + term: >- + CUX1 Gene + source: NCIt + cde_id: C95578 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95578" + term_id: C95578 + term_version: 20.10d + +cxcr4: + common: + description: >- + This gene is involved in the mediation of viral entry into cells and cellular + migration and chemotaxis. + termDef: + term: >- + CXCR4 Gene + source: NCIt + cde_id: C24327 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24327" + term_id: C24327 + term_version: 20.10d + +cxcr4eselectin_antagonist_gmi1359: + common: + description: >- + An antagonist of both the C-X-C chemokine receptor type 4 (CXCR4) and E-selectin + (CD62E), with potential antineoplastic activity. Upon administration, CXCR4/E-selectin + antagonist GMI-1359 binds to both CXCR4 and E-selectin expressed on endothelial + cells. The binding to CXCR4 prevents the binding of stromal-cell derived factor-1 + (SDF-1; CXCL12) to CXCR4 and inhibits CXCR4 activation, which may result in + decreased proliferation and migration of CXCR4-expressing tumor cells. The binding + to E-selectin expressed on endothelial cells prevents their interaction with + E-selectin ligand-expressing cancer cells. This may prevent tumor cell activation, + migration and metastasis. CXCR4, a chemokine receptor belonging to the G protein-coupled + receptor (GPCR) family, plays an important role in chemotaxis and angiogenesis, + and is upregulated in several tumor cell types. E-selectin is a cell adhesion + molecule involved in cell rolling, signaling and chemotaxis. Its overexpression + has been associated with tumor angiogenesis and metastasis in several cancers. + termDef: + term: >- + CXCR4/E-selectin Antagonist GMI-1359 + source: NCIt + cde_id: C167271 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167271" + term_id: C167271 + term_version: 20.10d + +cyld: + common: + description: >- + This gene is involved in protein deubiquitination. + termDef: + term: >- + CYLD Gene + source: NCIt + cde_id: C92678 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92678" + term_id: C92678 + term_version: 20.10d + +cylindrical_cell_carcinoma: + common: + description: >- + A squamous cell carcinoma of the sinonasal tract characterized by a plexiform + or ribbon-like growth pattern, cytological atypia, and lack of histological + evidence of keratinization. + termDef: + term: >- + Non-Keratinizing Sinonasal Squamous Cell Carcinoma + source: NCIt + cde_id: C54287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54287" + term_id: C54287 + term_version: 20.05a + +cylindroma_nos: + common: + description: >- + A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic + epithelial cells form cylindrical spatial configurations (cribriform or classic + type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid + cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid + cystic carcinomas mostly occur in the salivary glands. Other primary sites + of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid + cystic carcinomas spread along nerve sheaths, resulting in severe pain, and + they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread + is characteristic. + termDef: + term: >- + Adenoid Cystic Carcinoma + source: NCIt + cde_id: C2970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2970" + term_id: C2970 + term_version: 20.05a + +cylindroma_of_skin: + common: + description: >- + A benign sweat gland neoplasm usually occurring in the scalp or the face. It + may present as solitary or multiple papular or nodular lesions. It may be a + sporadic lesion or part of Brooke-Spiegler syndrome. It arises from the dermis + and has a multinodular, circumscribed appearance. The nodules contain basaloid + cells with small, dark nuclei. Complete excision is usually curative. + termDef: + term: >- + Cylindroma + source: NCIt + cde_id: C27094 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27094" + term_id: C27094 + term_version: 20.05a + +cyp11a1_inhibitor_odm209: + common: + description: >- + An orally bioavailable inhibitor of the enzyme cytochrome 450 side-chain cleavage + (scc)(CYP11A1), with potential antineoplastic activity. Upon oral administration, + CYP11A1 inhibitor ODM-209 targets, binds to and inhibits the activity of CYP11A1. + This prevents the synthesis of all steroid hormones and their precursors. This + may inhibit the proliferation of hormone-positive tumor cells. CYP11A1, a mitochondrial + enzyme, catalyzes the conversion of cholesterol to pregnenolone (Preg), which + is the first rate-limiting step in steroid hormone biosynthesis. + termDef: + term: >- + CYP11A1 Inhibitor ODM-209 + source: NCIt + cde_id: C172052 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172052" + term_id: C172052 + term_version: 20.10d + +cyp17cyp11b2_inhibitor_lae001: + common: + description: >- + An orally bioavailable, non-steroidal, potent, reversible, dual inhibitor of + cytochrome P450 17 (CYP17 or CYP17A1) and CYP11B2, with potential antiandrogen + and antineoplastic activities. Upon oral administration, LAE001 inhibits the + enzymatic activity of CYP17A1 in both the testes and adrenal glands, thereby + inhibiting androgen production. This may decrease androgen-dependent growth + signaling and may inhibit cell proliferation of androgen-dependent tumor cells. + LAE001 also inhibits the enzymatic activity of CYP11B2, thereby inhibiting aldosterone + production. This may reduce the elevated aldosterone levels resulting from CYP17 + inhibition and androgen deprivation, leading to a reduction in mineralocorticoid + side effects including cardiovascular complications. The cytochrome P450 enzyme + CYP17A1, localized to the endoplasmic reticulum, exhibits both 17alpha-hydroxylase + and 17,20-lyase activities, and plays a key role in the steroidogenic pathway + that produces steroidal hormones. The cytochrome P450 enzyme CYP11B2, aldosterone + synthase, is an enzyme that plays a key role in aldosterone biosynthesis. + termDef: + term: >- + CYP17/CYP11B2 Inhibitor LAE001 + source: NCIt + cde_id: C102855 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102855" + term_id: C102855 + term_version: 20.10d + +cyp2c8: + common: + description: >- + This gene plays a role in drug metabolism. It is also involved in the oxidation + of both endobiotics and xenobiotics. + termDef: + term: >- + CYP2C8 Gene + source: NCIt + cde_id: C46071 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46071" + term_id: C46071 + term_version: 20.10d + +cyprus: + common: + description: >- + An island in the Mediterranean Sea, south of Turkey. + termDef: + term: >- + Cyprus + source: NCIt + cde_id: C16480 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16480" + term_id: C16480 + term_version: 19.12e + +cysltr2: + common: + description: >- + This gene is involved in cysteinyl leukotriene binding and signal transduction. + termDef: + term: >- + CYSLTR2 Gene + source: NCIt + cde_id: C143039 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143039" + term_id: C143039 + term_version: 20.10d + +cystadenocarcinoma_nos: + common: + description: >- + A malignant cystic epithelial neoplasm arising from the glandular epithelium. The + malignant epithelial cells invade the stroma. The cystic spaces contain serous + or mucinous fluid. Representative examples include ovarian and pancreatic cystadenocarcinomas. + termDef: + term: >- + Cystadenocarcinoma + source: NCIt + cde_id: C2971 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2971" + term_id: C2971 + term_version: 20.05a + +cystadenofibroma_nos: + common: + description: >- + A benign or borderline neoplasm that arises from the ovaries and the fallopian + tubes. It is characterized by the presence of cystic glandular structures and + fibrous tissue. + termDef: + term: >- + Cystadenofibroma + source: NCIt + cde_id: C8985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8985" + term_id: C8985 + term_version: 20.05a + +cystadenoma_nos: + common: + description: >- + A benign or borderline cystic epithelial neoplasm arising from the glandular + epithelium. The epithelial cells line the cystic spaces which contain serous + or mucinous fluid. Representative examples include ovarian and pancreatic cystadenomas. + termDef: + term: >- + Cystadenoma + source: NCIt + cde_id: C2972 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2972" + term_id: C2972 + term_version: 20.05a + +cystic_astrocytoma: + common: + description: >- + A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse + infiltration of neighboring central nervous system structures. These lesions + typically affect young adults and have a tendency for progression to anaplastic + astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse + astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified. + termDef: + term: >- + Diffuse Astrocytoma + source: NCIt + cde_id: C7173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7173" + term_id: C7173 + term_version: 20.05a + +cystic_hygroma: + common: + description: >- + A benign lymphatic neoplasm usually arising from the neck and characterized + by cystic dilation of the lymphatic vessels. + termDef: + term: >- + Cystic Hygroma + source: NCIt + cde_id: C3724 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3724" + term_id: C3724 + term_version: 20.05a + +cystic_lymphangioma: + common: + description: >- + A benign lymphatic neoplasm usually arising from the neck and characterized + by cystic dilation of the lymphatic vessels. + termDef: + term: >- + Cystic Hygroma + source: NCIt + cde_id: C3724 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3724" + term_id: C3724 + term_version: 20.05a + +cystic_mesothelioma_nos: + common: + description: >- + An intermediate grade neoplasm arising from mesothelial cells. It occurs in + the peritoneum, extraperitoneal space, omentum, or pelvic or abdominal viscera. + It is characterized by the presence of multiple cysts lined by flattened or + cuboidal mesothelial cells. There is no evidence of significant cytologic atypia + or increased mitotic activity. It usually occurs in young to middle-aged women. + Patients present with abdominal or pelvic mass and pain. Approximately half + of the cases recur. The recurrences may appear several years after the initial + diagnosis. Rare cases of transformation to malignant mesothelioma have also + been described. + termDef: + term: >- + Multicystic Mesothelioma + source: NCIt + cde_id: C3765 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3765" + term_id: C3765 + term_version: 20.05a + +cystic_partially_differentiated_nephroblastoma: + common: + description: >- + A variant of Wilms tumor of the kidney characterized by the presence of cystic + spaces separated by septa. The septa contain immature epithelial cells, immature + stromal cells, and blastema cells. Surgical resection is usually curative. + termDef: + term: >- + Cystic Partially Differentiated Kidney Nephroblastoma + source: NCIt + cde_id: C6897 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6897" + term_id: C6897 + term_version: 20.05a + +cystic_teratoma_nos: + common: + description: >- + Cystic Teratoma + termDef: + term: >- + Cystic Teratoma + source: NCIt + cde_id: C9014 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9014" + term_id: C9014 + term_version: 20.05a + +cystic_tumor_of_atrioventricular_node: + common: + description: >- + A multicystic tumor arising in the inferior interatrial septum in the region + of the atrioventricular node. The vast majority of patients present with complete + heart block and a minority with partial heart block. Sudden death is reported + in approximately 10% of the cases. It is a morphologically benign tumor composed + of cuboidal, transitional, or squamoid cells. The cells may also show sebaceous + differentiation and originate from the endoderm. + termDef: + term: >- + Cystic Tumor of the Atrioventricular Node + source: NCIt + cde_id: C45754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45754" + term_id: C45754 + term_version: 20.05a + +cystoma_nos: + common: + description: >- + A benign or borderline cystic epithelial neoplasm arising from the glandular + epithelium. The epithelial cells line the cystic spaces which contain serous + or mucinous fluid. Representative examples include ovarian and pancreatic cystadenomas. + termDef: + term: >- + Cystadenoma + source: NCIt + cde_id: C2972 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2972" + term_id: C2972 + term_version: 20.05a + +cystosarcoma_phyllodes_benign: + common: + description: >- + A benign, circumscribed fibroepithelial neoplasm arising from the breast and + rarely the prostate gland. It is characterized by the presence of epithelial + structures which are arranged in clefts and by a hypercellular mesenchymal stroma + which is organized in leaf-like structures. There is no evidence of cellular + atypia or sarcomatous features. + termDef: + term: >- + Benign Phyllodes Tumor + source: NCIt + cde_id: C4274 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4274" + term_id: C4274 + term_version: 20.05a + +cystosarcoma_phyllodes_malignant: + common: + description: >- + A phyllodes tumor with sarcomatous stroma. The sarcomatous component is usually + of the fibrosarcomatous type. Liposarcomatous, chondrosarcomatous, osteosarcomatous, + or rhabdomyosarcomatous differentiation may also occur in the stroma. It may + recur and metastasize following surgical resection. The lung and skeleton are + the anatomic sites most frequently involved by metastases. + termDef: + term: >- + Malignant Phyllodes Tumor + source: NCIt + cde_id: C4275 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4275" + term_id: C4275 + term_version: 20.05a + +cystosarcoma_phyllodes_nos: + common: + description: >- + A benign, borderline, or malignant fibroepithelial neoplasm arising from the + breast and rarely the prostate gland. It may recur following resection. The + recurrence rates are higher for borderline and malignant phyllodes tumors. In + borderline and malignant phyllodes tumors metastases to distant anatomic sites + can occur. The incidence of metastases is higher in malignant phyllodes tumors. + termDef: + term: >- + Phyllodes Tumor + source: NCIt + cde_id: C2977 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2977" + term_id: C2977 + term_version: 20.05a + +cystoscopy: + common: + description: >- + Endoscopic examination of the urinary bladder or urethra. + termDef: + term: >- + Cystoscopy + source: NCIt + cde_id: C16482 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16482" + term_id: C16482 + term_version: 20.05a + +cytogenetics_nos: + common: + description: >- + Techniques for analysis of chromosomal and subchromosomal properties and structures, + such as those to diagnose, classify, screen for, or manage genetic diseases + and abnormalities. + termDef: + term: >- + Cytogenetic Analysis + source: NCIt + cde_id: C18280 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18280" + term_id: C18280 + term_version: 20.10d + +cytology: + common: + description: >- + The light microscopic study of normal and abnormal cells in fine needle aspirates + (FNAs), body cavity fluids, and smears. + termDef: + term: >- + Cytology + source: NCIt + cde_id: C16491 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16491" + term_id: C16491 + term_version: 20.05a + +czech_republic_czechia: + common: + description: >- + A country in central Europe, southeast of Germany and southwest of Poland. + termDef: + term: >- + Czech Republic (Czechia) + source: NCIt + cde_id: C17668 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17668" + term_id: C17668 + term_version: 19.12e + +dabska_tumor: + common: + description: >- + An intermediate, rarely metastasizing blood vessel neoplasm. It is characterized + by the presence of lymphatic-like vascular channels and papillary endothelial + proliferation. + termDef: + term: >- + Papillary Intralymphatic Angioendothelioma + source: NCIt + cde_id: C7526 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7526" + term_id: C7526 + term_version: 20.05a + +daratumumab_and_hyaluronidasefihj: + common: + description: >- + A co-formulation composed of daratumumab, a human immunoglobulin (Ig) G1 kappa + monoclonal antibody directed against the cell surface glycoprotein cluster of + differentiation 38 (CD-38; CD38), and a recombinant form of human hyaluronidase + (rHuPH20), with potential antineoplastic activity. Upon subcutaneous administration + of daratumumab and hyaluronidase-fihj, daratumumab targets and binds to CD38 + on certain CD38-expressing tumors, such as multiple myeloma (MM) and plasma + cell leukemia. This binding induces direct apoptosis through Fc-mediated cross-linking + and triggers immune-mediated tumor cell lysis through antibody-dependent cellular + cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and antibody-dependent + cellular phagocytosis (ADCP) immune responses. CD38, a transmembrane glycoprotein, + is expressed in both hematopoietic and non-hematopoietic lineage cells. Hyaluronidase-fihj + hydrolyzes and degrades the glycosaminoglycan hyaluronic acid (HA), thereby + decreasing interstitial viscosity and enhancing penetration of daratumumab through + the interstitial space. This facilitates the delivery of daratumumab to CD38-expressing + tumor cells. + termDef: + term: >- + Daratumumab and Hyaluronidase-fihj + source: NCIt + cde_id: C156401 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156401" + term_id: C156401 + term_version: 20.10d + +daughter: + common: + description: >- + A female human offspring. + termDef: + term: >- + Daughter + source: NCIt + cde_id: C25165 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25165" + term_id: C25165 + term_version: 19.12e + +daughterinlaw: + common: + description: >- + The wife of your son. + termDef: + term: >- + Daughter-in-law + source: NCIt + cde_id: C71401 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71401" + term_id: C71401 + term_version: 19.12e + +daxx: + common: + description: >- + This gene plays a role in signal transduction, regulation of transcription and + enhancement of apoptosis. + termDef: + term: >- + DAXX Gene + source: NCIt + cde_id: C24330 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24330" + term_id: C24330 + term_version: 20.10d + +dcaf12l2: + common: + description: >- + This gene may play a role in protein complex formation. + termDef: + term: >- + DCAF12L2 Gene + source: NCIt + cde_id: C143036 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143036" + term_id: C143036 + term_version: 20.10d + +dcc: + common: + description: >- + This gene plays a role in the regulation of several processes that determine + neuronal cell morphology. + termDef: + term: >- + DCC Gene + source: NCIt + cde_id: C17358 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17358" + term_id: C17358 + term_version: 20.10d + +dcis_nos: + common: + description: >- + A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There + is no evidence of invasion of the basement membrane. Currently, it is classified + into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade + DCIS. In this classification the DCIS grade is defined by a combination of nuclear + grade, architectural growth pattern and presence of necrosis. The size of the + lesion as well as the grade and the clearance margins play a major role in dictating + the most appropriate therapy for DCIS. + termDef: + term: >- + Ductal Breast Carcinoma In Situ + source: NCIt + cde_id: C2924 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2924" + term_id: C2924 + term_version: 20.05a + +dcis_papillary: + common: + description: >- + A non-invasive breast adenocarcinoma located in a distended duct. It is characterized + by the presence of papillary structures with fibrovascular stalks. In the absence + of ductal carcinoma in situ or invasive carcinoma in adjacent tissues, the prognosis + is usually favorable. + termDef: + term: >- + Intraductal Papillary Breast Carcinoma + source: NCIt + cde_id: C4190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4190" + term_id: C4190 + term_version: 20.05a + +dctn1: + common: + description: >- + This gene is involved in the modulation of retrograde transport of cytoplasmic + organelles and vesicles. + termDef: + term: >- + DCTN1 Gene + source: NCIt + cde_id: C122875 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122875" + term_id: C122875 + term_version: 20.10d + +ddb2: + common: + description: >- + This gene plays a role in DNA repair. + termDef: + term: >- + DDB2 Gene + source: NCIt + cde_id: C93075 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93075" + term_id: C93075 + term_version: 20.10d + +ddit3: + common: + description: >- + This gene plays a role in the modulation of transcription. + termDef: + term: >- + DDIT3 Gene + source: NCIt + cde_id: C92539 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92539" + term_id: C92539 + term_version: 20.10d + +ddr2: + common: + description: >- + This gene plays a role in extracellular matrix communication processes and receptor-mediated + signal transduction. + termDef: + term: >- + DDR2 Gene + source: NCIt + cde_id: C24333 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24333" + term_id: C24333 + term_version: 20.10d + +ddx10: + common: + description: >- + This gene plays a role in both RNA metabolism and ATP hydrolysis. + termDef: + term: >- + DDX10 Gene + source: NCIt + cde_id: C97457 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97457" + term_id: C97457 + term_version: 20.10d + +ddx3x: + common: + description: >- + This gene is involved in RNA binding. + termDef: + term: >- + DDX3X Gene + source: NCIt + cde_id: C101565 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101565" + term_id: C101565 + term_version: 20.10d + +ddx5: + common: + description: >- + This gene is involved in the mediation of RNA metabolism. + termDef: + term: >- + DDX5 Gene + source: NCIt + cde_id: C97460 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97460" + term_id: C97460 + term_version: 20.10d + +ddx6: + common: + description: >- + This gene plays a role in the translation of mRNA encoded by genes involved + in cell proliferation and malignant transformation. + termDef: + term: >- + DDX6 Gene + source: NCIt + cde_id: C18378 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18378" + term_id: C18378 + term_version: 20.10d + +dead: + common: + description: >- + The cessation of life. + termDef: + term: >- + Dead + source: NCIt + cde_id: C28554 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28554" + term_id: C28554 + term_version: 19.12e + +death_certificate: + common: + description: >- + A certified document issued by either a medical practitioner or a governmental + agency that details the date, location and cause of a death of an individual. + termDef: + term: >- + Death Certificate + source: NCIt + cde_id: C163970 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C163970" + term_id: C163970 + term_version: 19.12e + +debulking: + common: + description: >- + The surgical removal of as much of a malignant tumor as is reasonably possible. + This procedure increases the effectiveness of the subsequent administration + of chemotherapy and/or radiation therapy. + termDef: + term: >- + Tumor Debulking + source: NCIt + cde_id: C15749 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15749" + term_id: C15749 + term_version: 20.05a + +decitabine_and_cedazuridine: + common: + description: >- + An orally available fixed-dose combination agent containing cedazuridine, a + cytidine deaminase (CDA) inhibitor, and the cytidine antimetabolite decitabine, + with potential antineoplastic activity. Upon oral administration of tdecitabine + and cedazuridine, cedazuridine binds to and inhibits CDA, an enzyme primarily + found in the gastrointestinal (GI) tract and liver that catalyzes the deamination + of cytidine and cytidine analogs. This prevents the breakdown of decitabine, + increases its bioavailability and efficacy while decreasing GI toxicity due + to the administration of lower doses of decitabine. Decitabine exerts its antineoplastic + activity through the incorporation of its triphosphate form into DNA, which + inhibits DNA methyltransferase and results in hypomethylation of DNA. This interferes + with DNA replication and decreases tumor cell growth. + termDef: + term: >- + Decitabine and Cedazuridine + source: NCIt + cde_id: C115102 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C115102" + term_id: C115102 + term_version: 20.10d + +dedifferentiated_chondrosarcoma: + common: + description: >- + An aggressive morphologic variant of chondrosarcoma. It is composed of a low + grade chondrosarcoma and a high grade non-cartilagenous sarcomatous component. + Due to the aggressive nature of the disease, its prognosis is poor. + termDef: + term: >- + Dedifferentiated Chondrosarcoma + source: NCIt + cde_id: C6476 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6476" + term_id: C6476 + term_version: 20.05a + +dedifferentiated_chordoma: + common: + description: >- + A high-grade malignant bone tumor arising from the remnants of the notochord. + It is characterized by a lobulated growth pattern, myxoid stroma formation, + the presence of physaliphorous cells, and a sarcomatous component. + termDef: + term: >- + Dedifferentiated Chordoma + source: NCIt + cde_id: C48876 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48876" + term_id: C48876 + term_version: 20.05a + +dedifferentiated_liposarcoma: + common: + description: >- + An atypical lipomatous tumor/well differentiated liposarcoma that shows progression + to a usually non-lipomatous, high grade sarcoma. The non-lipomatous sarcoma + component may be present in the primary lesion or at the site of recurrence. + termDef: + term: >- + Dedifferentiated Liposarcoma + source: NCIt + cde_id: C3704 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3704" + term_id: C3704 + term_version: 20.05a + +deep_gray_eg_basal_ganglia_thalamus: + common: + description: >- + The gray matter that includes the basal ganglia and/or thalamus. + termDef: + term: >- + Deep Gray Matter + source: NCIt + cde_id: C158080 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C158080" + term_id: C158080 + term_version: 20.05a + +deep_histiocytoma: + common: + description: >- + A rare, well-circumscribed, pseudo-encapsulated benign fibrous histiocytoma + that arises entirely within the subcutaneous tissue or deep soft tissue. It + usually affects the extremities or the head and neck region. It recurs locally + in a minority of cases. + termDef: + term: >- + Deep Benign Fibrous Histiocytoma + source: NCIt + cde_id: C6492 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6492" + term_id: C6492 + term_version: 20.05a + +degenerated_schwannoma: + common: + description: >- + A schwannoma that is characterized by degenerative changes such as hyalinization, + hemorrhage, calcification and cystic change. + termDef: + term: >- + Degenerated Schwannoma + source: NCIt + cde_id: C6556 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6556" + term_id: C6556 + term_version: 20.05a + +dek: + common: + description: >- + This gene is involved in RNA processing and regulation of chromatin organization. + termDef: + term: >- + DEK Gene + source: NCIt + cde_id: C24339 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24339" + term_id: C24339 + term_version: 20.10d + +deletion: + common: + description: >- + Any rearrangement to the genomic content that results in the loss of one or + more nucleotides of DNA. Deletions are generally irreversible rearrangements. + They may alter the reading frame of a gene, or may result in loss of large chromosomal + regions. + termDef: + term: >- + Deletion Mutation + source: NCIt + cde_id: C19296 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19296" + term_id: C19296 + term_version: 20.10d + +deletioninsertion: + common: + description: >- + A change in a nucleotide sequence where nucleotides in a reference sequence + are replaced by other nucleotides and which is not a substitution, inversion + or conversion. + termDef: + term: >- + Delins Mutation + source: NCIt + cde_id: C171175 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171175" + term_id: C171175 + term_version: 20.10d + +delolimogene_mupadenorepvec: + common: + description: >- + A double-armed oncolytic adenovirus composed of a recombinant genetically modified + E1/E3-deleted, adenoviral serotype 5 (Ad5) vector, with the L5 segment of the + Ad5 fiber replaced by the shaft and knob from the Ad35 serotype (Ad5/35), which + expresses a trimerized (TMZ) form of the membrane-bound immunostimulator CD40 + ligand (CD40L; TNFSF5) and the ligand for the signaling domain 4-1BB (4-1BBL; + CD137L; TNFSF9), under the control of a CMV promoter, with potential immunostimulating + and antineoplastic activities. Upon intratumoral administration of delolimogene + mupadenorepvec, the virus infects and selectively replicates in tumor cells. + This causes direct oncolysis and the release of a plethora of tumor-associated + antigens (TAAs) from the tumor cells. The released TAAs stimulate the immune + system and activate anti-tumor cytotoxic T-lymphocytes (CTLs), thereby further + killing tumor cells. In addition, infected tumor cells and tumor stroma cells, + including stellate cells and infiltrating immune cells, express the immunostimulants + CD40L and 4-1BBL. The expressed CD40L and 4-1BBL proteins activate the CD40L- + and 4-1BBL-mediated signaling pathways, respectively. This activates antigen-presenting + cells (APCs), such as dendritic cells (DCs) and M1 macrophages. The DCs produce + various cytokines, including interleukin-12 (IL12), IL21, tumor necrosis factor-alpha + (TNFa), and interferon-gamma (IFNg), which leads to the activation and expansion + of both T-cells and natural killer (NK) cells. Altogether, this modulates immune + suppression in the tumor microenvironment (TME), disrupts tumor stroma, and + causes additional immune stimulation against tumor cells, thereby inducing further + tumor cell lysis. In addition, CD40L reduces myeloid suppressor cells in the + TME. Inclusion of the chimeric Ad5/35 fiber targets CD46 and increases viral + uptake in cells. Transgene expression is driven by a separate promoter to allow + for efficient expression in both tumor cells and tumor stroma. Replication is + restricted to tumor cells by the presence of the delta24 mutation in the E1A + gene, which deletes the retinoplastoma protein (pRb)-binding domain and forces + viral replication to be conditional on hyperphosphorylated pRb and a dysfunctional + Rb pathway. + termDef: + term: >- + Delolimogene Mupadenorepvec + source: NCIt + cde_id: C148462 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148462" + term_id: C148462 + term_version: 20.10d + +democratic_republic_of_the_congo: + common: + description: >- + A country in central Africa, northeast of Angola. + termDef: + term: >- + Democratic Republic of the Congo + source: NCIt + cde_id: C17266 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17266" + term_id: C17266 + term_version: 19.12e + +dendrimerconjugated_bcl2bclxl_inhibitor_azd0466: + common: + description: >- + A drug-dendrimer conjugate composed of a B-cell lymphoma 2 (Bcl-2)/Bcl-XL inhibitor + AZD4320 that is chemically conjugated to a proprietary 5-generation pegylated + poly-lysine dendrimer via a hydrolytically labile linker, with potential pro-apoptotic + and antineoplastic activities. Upon administration of AZD0466, AZD4320 is released + through hydrolytic cleavage of the linker. AZD4320 is a Bcl2-homology domain + 3 (BH3) mimetic that specifically binds to and inhibits the activity of the + anti-apoptotic proteins Bcl-2 and Bcl-XL. This restores apoptotic processes + and inhibits cell proliferation in Bcl-2/Bcl-XL-dependent tumor cells. Bcl-2 + and Bcl-XL, proteins belonging to the Bcl-2 family that are overexpressed in + many cancers, play an important role in the negative regulation of apoptosis. + Their expression in tumors is associated with increased drug resistance and + cancer cell survival. The conjugation of AZD 4320 to the dendrimer construct + may allow extended release of the agent, which may improve efficacy and lower + toxicity. + termDef: + term: >- + Dendrimer-conjugated Bcl-2/Bcl-XL Inhibitor AZD0466 + source: NCIt + cde_id: C173660 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173660" + term_id: C173660 + term_version: 20.10d + +dendritic_cell_sarcoma_nos: + common: + description: >- + A dendritic cell neoplasm that does not fall into well-defined categories or + shows hybrid features. + termDef: + term: >- + Dendritic Cell Tumor, Not Otherwise Specified + source: NCIt + cde_id: C27260 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27260" + term_id: C27260 + term_version: 20.05a + +dengue_virus_adjuvant_pv001dv: + common: + description: >- + 45AZ5, with potential immunostimulating activity. Upon administration of dengue + virus adjuvant PV-001-DV, the virus may activate both the innate and adaptive + immune system. + termDef: + term: >- + Dengue Virus Adjuvant PV-001-DV + source: NCIt + cde_id: C173443 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173443" + term_id: C173443 + term_version: 20.10d + +denmark: + common: + description: >- + A country in northern Europe, bordering the Baltic Sea and the North Sea, consisting + of a peninsula on the north coast of Germany and several major islands. + termDef: + term: >- + Denmark + source: NCIt + cde_id: C16496 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16496" + term_id: C16496 + term_version: 19.12e + +dentinoma: + common: + description: >- + A locally aggressive neoplasm arising from tooth-forming tissues. It is more + often intraosseous and less frequently extraosseous and occurs in the jaw. It + is characterized by the presence of ameloblastoma-like epithelium, connective + tissue stroma, ghost cells, and dysplastic dentin. Wide local resection is recommended + for intraosseous neoplasms and enucleation for extraosseous neoplasms. + termDef: + term: >- + Dentinogenic Ghost Cell Tumor + source: NCIt + cde_id: C54323 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54323" + term_id: C54323 + term_version: 20.05a + +dermal_and_epidermal_nevus: + common: + description: >- + A nevus composed of neoplastic melanocytes that infiltrate both the epidermis + and the dermis. + termDef: + term: >- + Compound Nevus + source: NCIt + cde_id: C3901 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3901" + term_id: C3901 + term_version: 20.05a + +dermal_nevus: + common: + description: >- + A nevus characterized by the proliferation of nevus cells in the dermis without + involvement of the dermal-epidermal junction. + termDef: + term: >- + Dermal Nevus + source: NCIt + cde_id: C3804 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3804" + term_id: C3804 + term_version: 20.05a + +dermatofibroma_lenticulare: + common: + description: >- + A solitary, slowly growing, nodular tumor most often affecting the extremities. + It is composed of fibrous and histiocytic cells which infiltrate the dermis + and occasionally the underlying subcutaneous tissue. Usually local excision + is curative. Recurrences are reported only in a small minority of cases. + termDef: + term: >- + Skin Fibrous Histiocytoma + source: NCIt + cde_id: C6801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6801" + term_id: C6801 + term_version: 20.05a + +dermatofibroma_nos: + common: + description: >- + A solitary, slowly growing, nodular tumor most often affecting the extremities. + It is composed of fibrous and histiocytic cells which infiltrate the dermis + and occasionally the underlying subcutaneous tissue. Usually local excision + is curative. Recurrences are reported only in a small minority of cases. + termDef: + term: >- + Skin Fibrous Histiocytoma + source: NCIt + cde_id: C6801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6801" + term_id: C6801 + term_version: 20.05a + +dermatofibrosarcoma_nos: + common: + description: >- + A low grade fibroblastic neoplasm presenting as a nodular cutaneous mass, most + often on the trunk and the proximal extremities. The tumor diffusely infiltrates + the dermis and the subcutaneous tissues. It is considered a locally aggressive + neoplasm, which often recurs but rarely metastasizes. + termDef: + term: >- + Dermatofibrosarcoma Protuberans + source: NCIt + cde_id: C4683 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4683" + term_id: C4683 + term_version: 20.05a + +dermatofibrosarcoma_protuberans_nos: + common: + description: >- + A low grade fibroblastic neoplasm presenting as a nodular cutaneous mass, most + often on the trunk and the proximal extremities. The tumor diffusely infiltrates + the dermis and the subcutaneous tissues. It is considered a locally aggressive + neoplasm, which often recurs but rarely metastasizes. + termDef: + term: >- + Dermatofibrosarcoma Protuberans + source: NCIt + cde_id: C4683 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4683" + term_id: C4683 + term_version: 20.05a + +dermoid_cyst_nos: + common: + description: >- + A mature teratoma characterized by the presence of a cyst which is lined by + mature tissue resembling the epidermis and the epidermal appendages. It occurs + in the ovary, testis, and extragonadal sites including central nervous system + and skin. + termDef: + term: >- + Dermoid Cyst + source: NCIt + cde_id: C9011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9011" + term_id: C9011 + term_version: 20.05a + +dermoid_cyst_with_malignant_transformation: + common: + description: >- + A teratoma which is characterized by morphologic transformation to malignancy + and an aggressive clinical course. The malignant component most often is sarcomatous + or carcinomatous. + termDef: + term: >- + Teratoma with Somatic-Type Malignancy + source: NCIt + cde_id: C4289 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4289" + term_id: C4289 + term_version: 20.05a + +dermoid_cyst_with_secondary_tumor: + common: + description: >- + A teratoma which is characterized by morphologic transformation to malignancy + and an aggressive clinical course. The malignant component most often is sarcomatous + or carcinomatous. + termDef: + term: >- + Teratoma with Somatic-Type Malignancy + source: NCIt + cde_id: C4289 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4289" + term_id: C4289 + term_version: 20.05a + +dermoid_nos: + common: + description: >- + A mature teratoma characterized by the presence of a cyst which is lined by + mature tissue resembling the epidermis and the epidermal appendages. It occurs + in the ovary, testis, and extragonadal sites including central nervous system + and skin. + termDef: + term: >- + Dermoid Cyst + source: NCIt + cde_id: C9011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9011" + term_id: C9011 + term_version: 20.05a + +descending_colon: + common: + description: >- + The fourth portion of the large intestine (colon) that communicates with the + transverse colon in the left-upper quadrant of the abdomen and the rectum below. + termDef: + term: >- + Descending Colon + source: NCIt + cde_id: C12268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12268" + term_id: C12268 + term_version: 20.05a + +desmoid_nos: + common: + description: >- + An insidious, locally aggressive, poorly circumscribed neoplasm arising from + the deep soft tissues. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + It lacks metastatic potential. + termDef: + term: >- + Desmoid-Type Fibromatosis + source: NCIt + cde_id: C9182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9182" + term_id: C9182 + term_version: 20.05a + +desmoplastic_fibroma: + common: + description: >- + A rare, benign, locally aggressive, osteolytic neoplasm. It is characterized + by the presence of a rich collagenous stroma and spindle cells with minimal + cellular atypia. + termDef: + term: >- + Bone Desmoplastic Fibroma + source: NCIt + cde_id: C3740 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3740" + term_id: C3740 + term_version: 20.05a + +desmoplastic_infantile_astrocytoma: + common: + description: >- + A WHO grade I large cystic tumor that occurs almost exclusively in infants, + with a prominent desmoplastic stroma having a neuroepithelial population consisting + mainly of neoplastic astrocytes. It involves the superficial cerebral cortex + and leptomeninges, and often attaches to the dura. Although clinically it presents + as large tumor, it generally has a good prognosis following surgical resection. + (Adapted from WHO) + termDef: + term: >- + Desmoplastic Infantile Astrocytoma + source: NCIt + cde_id: C9476 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9476" + term_id: C9476 + term_version: 20.05a + +desmoplastic_infantile_ganglioglioma: + common: + description: >- + A WHO grade I large cystic tumor that occurs almost exclusively in infants, + with a prominent desmoplastic stroma having a neuroepithelial population of + neoplastic astrocytes together with a variable neuronal component. It involves + the superficial cerebral cortex and leptomeninges, and often attaches to the + dura. Although clinically it presents as a large tumor, it generally has a good + prognosis following surgical resection. (Adapted from WHO) + termDef: + term: >- + Desmoplastic Infantile Ganglioglioma + source: NCIt + cde_id: C4738 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4738" + term_id: C4738 + term_version: 20.05a + +desmoplastic_medulloblastoma: + common: + description: >- + A medulloblastoma characterized by the presence of nodular, collagenous areas + which do not contain reticulin, surrounded by hypercellular areas which contain + an intercellular reticulin fiber network. + termDef: + term: >- + Desmoplastic/Nodular Medulloblastoma + source: NCIt + cde_id: C4956 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4956" + term_id: C4956 + term_version: 20.05a + +desmoplastic_melanoma_amelanotic: + common: + description: >- + A melanoma of the skin characterized by a proliferation of atypical spindled + melanocytes in the dermis, in a background of abundant collagen. It usually + presents as an amelanotic raised nodular lesion. + termDef: + term: >- + Desmoplastic Melanoma + source: NCIt + cde_id: C37257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37257" + term_id: C37257 + term_version: 20.05a + +desmoplastic_melanoma_malignant: + common: + description: >- + A melanoma of the skin characterized by a proliferation of atypical spindled + melanocytes in the dermis, in a background of abundant collagen. It usually + presents as an amelanotic raised nodular lesion. + termDef: + term: >- + Desmoplastic Melanoma + source: NCIt + cde_id: C37257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37257" + term_id: C37257 + term_version: 20.05a + +desmoplastic_mesothelioma: + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of a dense collagenous tissue and atypical neoplastic cells. Sarcomatoid + features, collagenous necrosis, and infiltration of muscle and adipose tissue + may be present. It occurs in the pleura and less commonly in the peritoneum. + termDef: + term: >- + Desmoplastic Mesothelioma + source: NCIt + cde_id: C6747 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6747" + term_id: C6747 + term_version: 20.05a + +desmoplastic_nodular_medulloblastoma: + common: + description: >- + A medulloblastoma characterized by the presence of nodular, collagenous areas + which do not contain reticulin, surrounded by hypercellular areas which contain + an intercellular reticulin fiber network. + termDef: + term: >- + Desmoplastic/Nodular Medulloblastoma + source: NCIt + cde_id: C4956 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4956" + term_id: C4956 + term_version: 20.05a + +desmoplastic_small_round_cell_tumor: + common: + description: >- + An aggressive malignant soft tissue neoplasm of uncertain differentiation. It + is characterized by a recurrent chromosomal translocation t(11;22)(p13;q12) + and the presence of small round cells in a desmoplastic stroma. It usually + affects children and young adults. The most common site of involvement is the + abdomen. Patients usually present with abdominal distention, pain, ascites, + and a palpable abdominal mass. The prognosis is usually poor. + termDef: + term: >- + Desmoplastic Small Round Cell Tumor + source: NCIt + cde_id: C8300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8300" + term_id: C8300 + term_version: 20.05a + +dgcr8: + common: + description: >- + This gene plays a role in microRNA processing. + termDef: + term: >- + DGCR8 Gene + source: NCIt + cde_id: C92663 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92663" + term_id: C92663 + term_version: 20.10d + +di_guglielmo_disease: + common: + description: >- + Acute erythroid leukemia characterised by the presence of immature erythroid + cells in the bone marrow (at least 80% of the cellular component), without evidence + of a significant myeloblastic cell population present. + termDef: + term: >- + Pure Erythroid Leukemia + source: NCIt + cde_id: C7467 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7467" + term_id: C7467 + term_version: 20.05a + +diagnostic_imaging: + common: + description: >- + Any method that uses a visual display of structural or functional patterns of + organs or tissues for diagnostic evaluation. + termDef: + term: >- + Diagnostic Imaging + source: NCIt + cde_id: C16502 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16502" + term_id: C16502 + term_version: 20.05a + +dicer1: + common: + description: >- + This gene is involved in the RNA interference pathway. + termDef: + term: >- + DICER1 Gene + source: NCIt + cde_id: C25956 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25956" + term_id: C25956 + term_version: 20.10d + +differentiatedtype_vulvar_intraepithelial_neoplasia: + common: + description: >- + HPV-negative vulvar squamous intraepithelial proliferation with abnormal keratinocyte + differentiation and basal cell atypia. These lesions are most strongly linked + to cancer by association rather than outcome. Risk of progression to invasion + is unclear but can be rapid, often less than six months. Management is predicated + on complete removal. (WHO, 2014) + termDef: + term: >- + Vulvar Intraepithelial Neoplasia, Differentiated Type + source: NCIt + cde_id: C37272 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37272" + term_id: C37272 + term_version: 20.05a + +differentiating: + common: + description: >- + A neuroblastoma in which the differentiating neuroblasts constitute more than + five-percent of the tumor cells. + termDef: + term: >- + Differentiating Neuroblastoma + source: NCIt + cde_id: C42048 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C42048" + term_id: C42048 + term_version: 20.05a + +diffuse: + common: + description: >- + Widely spread; not localized or confined. + termDef: + term: >- + Diffuse + source: NCIt + cde_id: C14175 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C14175" + term_id: C14175 + term_version: 20.05a + +diffuse_astrocytoma: + common: + description: >- + A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse + infiltration of neighboring central nervous system structures. These lesions + typically affect young adults and have a tendency for progression to anaplastic + astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse + astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified. + termDef: + term: >- + Diffuse Astrocytoma + source: NCIt + cde_id: C7173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7173" + term_id: C7173 + term_version: 20.05a + +diffuse_astrocytoma_idhmutant: + common: + description: >- + Diffuse astrocytoma carrying IDH mutations. + termDef: + term: >- + Diffuse Astrocytoma, IDH-Mutant + source: NCIt + cde_id: C129271 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129271" + term_id: C129271 + term_version: 20.05a + +diffuse_astrocytoma_idhwildtype: + common: + description: >- + Diffuse astrocytoma lacking mutations in IDH1 or IDH2 genes. + termDef: + term: >- + Diffuse Astrocytoma, IDH-Wildtype + source: NCIt + cde_id: C129274 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129274" + term_id: C129274 + term_version: 20.05a + +diffuse_astrocytoma_low_grade: + common: + description: >- + A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse + infiltration of neighboring central nervous system structures. These lesions + typically affect young adults and have a tendency for progression to anaplastic + astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse + astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified. + termDef: + term: >- + Diffuse Astrocytoma + source: NCIt + cde_id: C7173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7173" + term_id: C7173 + term_version: 20.05a + +diffuse_cutaneous_mastocytosis: + common: + description: >- + A variant of cutaneous mastocytosis which is seen almost exclusively in children. + (WHO, 2001) + termDef: + term: >- + Diffuse Cutaneous Mastocytosis + source: NCIt + cde_id: C3218 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3218" + term_id: C3218 + term_version: 20.05a + +diffuse_intraductal_papillomatosis: + common: + description: >- + Diffuse Intraductal Papillomatosis + termDef: + term: >- + Diffuse Intraductal Papillomatosis + source: NCIt + cde_id: C7364 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7364" + term_id: C7364 + term_version: 20.05a + +diffuse_large_bcell_lymphoma_associated_with_chronic_inflammation: + common: + description: >- + A diffuse large B-cell lymphoma arising in body cavities or narrow spaces of + long standing chronic inflammation. The classic example is the pyothorax-associated + lymphoma that arises in the pleural cavity of patients with a history of long + standing pyothorax. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation + source: NCIt + cde_id: C80289 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80289" + term_id: C80289 + term_version: 20.05a + +diffuse_large_bcell_lymphoma_nos: + common: + description: >- + A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly + large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin + lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic + lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities + include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large + B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary + cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell + lymphoma. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma + source: NCIt + cde_id: C8851 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8851" + term_id: C8851 + term_version: 20.05a + +diffuse_leptomeningeal_glioneuronal_tumor: + common: + description: >- + A relatively slow growing diffuse leptomeningeal neoplasm usually affecting + children and adolescents. It is characterized by the presence of clear glial + neoplastic cells reminiscent of oligodendroglioma. A neuronal component may + be present. The prognosis is variable. + termDef: + term: >- + Diffuse Leptomeningeal Glioneuronal Tumor + source: NCIt + cde_id: C129424 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129424" + term_id: C129424 + term_version: 20.05a + +diffuse_melanocytosis: + common: + description: >- + A diffuse or multifocal proliferation of uniform nevoid polygonal cells in the + leptomeninges. Cells may spread into the Virchow-Robin spaces without frank + invasion of the brain. Diffuse melanocytosis carries a poor prognosis even in + the absence of histologic malignancy. (WHO) + termDef: + term: >- + Meningeal Melanocytosis + source: NCIt + cde_id: C6890 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6890" + term_id: C6890 + term_version: 20.05a + +diffuse_meningiomatosis: + common: + description: >- + The presence of multiple meningiomas in the leptomeninges. + termDef: + term: >- + Meningiomatosis + source: NCIt + cde_id: C3707 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3707" + term_id: C3707 + term_version: 20.05a + +diffuse_midline_glioma_h3_k27mmutant: + common: + description: >- + A childhood diffuse midline glioma characterized by the presence of histone + H3 K27M mutation. + termDef: + term: >- + Diffuse Midline Glioma, H3 K27M-Mutant + source: NCIt + cde_id: C129309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129309" + term_id: C129309 + term_version: 20.05a + +digital_papillary_adenocarcinoma: + common: + description: >- + An adenocarcinoma arising from the sweat glands. Most cases present as nodular + lesions on the digits, usually in the hands. It is characterized by the presence + of epithelial cells in the dermis forming nodules. Cystic structures containing + papillary projections are also present. It may recur and metastasize, most commonly + to the lungs. + termDef: + term: >- + Digital Papillary Adenocarcinoma + source: NCIt + cde_id: C27534 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27534" + term_id: C27534 + term_version: 20.05a + +diktyoma_malignant: + common: + description: >- + A rare, usually aggressive malignant embryonal neoplasm of the central nervous + system occurring in children. It is characterized by the presence of neuroepithelial + cells which form papillary, trabecular, or tubular structures and absence of + C19MC amplification. Symptoms include headache, nausea, and vomiting. + termDef: + term: >- + Medulloepithelioma + source: NCIt + cde_id: C4327 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4327" + term_id: C4327 + term_version: 20.05a + +dilation_and_curettage_procedure: + common: + description: >- + A surgical scraping and removal of the inner lining of the uterus through direct + dilation of the uterine cervix. + termDef: + term: >- + Dilation and Curettage + source: NCIt + cde_id: C15226 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15226" + term_id: C15226 + term_version: 20.05a + +dilpacimab: + common: + description: >- + A dual-specific, tetravalent immunoglobulin (Ig) G-like molecule targeting two + as of yet not publicly known targets, with potential antineoplastic activity. + The target-binding variable domains of two monoclonal antibodies, which are + not publicly known, are combined, via linkers, to create the tetravalent, dual-targeting + single agent ABT-165. Upon administration of dual variable domain immunoglobulin + (DVD-Ig) ABT-165, the target-binding variable domains specifically recognize + and simultaneously bind to their two antigens expressed on tumor cells. This + may both prevent antigen-mediated signaling and lead to an inhibition of cellular + proliferation in susceptible tumor cells. The antigen targets are overexpressed + on certain tumor cell types. The DVD-Ig may have enhanced physicochemical and + pharmacokinetic properties as compared to their antibody counterparts. + termDef: + term: >- + Dilpacimab + source: NCIt + cde_id: C116750 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116750" + term_id: C116750 + term_version: 20.10d + +din_3: + common: + description: >- + A ductal carcinoma in situ characterized by the presence of neoplastic cells + with severe dysplasia and the formation of micropapillary, cribriform, or solid + patterns. The nuclei show marked pleomorphism and have prominent nucleoli. Mitotic + activity is usually present. There is comedo-type of necrosis present in the + ducts. The necrotic debris is surrounded by pleomorphic malignant cells. + termDef: + term: >- + High Grade Ductal Breast Carcinoma In Situ + source: NCIt + cde_id: C7949 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7949" + term_id: C7949 + term_version: 20.05a + +diploid: + common: + description: >- + Having two sets of homologous chromosomes. + termDef: + term: >- + Diploidy + source: NCIt + cde_id: C118941 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C118941" + term_id: C118941 + term_version: 20.10d + +distant_metastasis: + common: + description: >- + A biological process that involves the transfer and growth of cancer cells from + the site of the primary tumor. Relocation of malignant cells during metastasis + can be restricted to movement within a specific tissue/organ or may entail migration + to a distal locus within the body. This phenotype is a characteristic of all + malignant tumors. + termDef: + term: >- + Distant Metastasis + source: NCIt + cde_id: C18206 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18206" + term_id: C18206 + term_version: 20.05a + +djibouti: + common: + description: >- + A country in eastern Africa, bordering the Gulf of Aden and the Red Sea, between + Eritrea and Somalia. + termDef: + term: >- + Djibouti + source: NCIt + cde_id: C16506 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16506" + term_id: C16506 + term_version: 19.12e + +dna: + common: + description: >- + A long linear double-stranded polymer formed from nucleotides attached to a + deoxyribose backbone and found in the nucleus of a cell; associated with the + transmission of genetic information. + termDef: + term: >- + DNA + source: NCIt + cde_id: C449 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C449" + term_id: C449 + term_version: 20.10d + +dnajb1: + common: + description: >- + This gene plays a role in the regulation of protein folding. + termDef: + term: >- + DNAJB1 Gene + source: NCIt + cde_id: C122560 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122560" + term_id: C122560 + term_version: 20.10d + +dnapk_inhibitor_azd7648: + common: + description: >- + An orally bioavailable ATP-competitive inhibitor of DNA-dependent protein kinase + (DNA-PK), with potential chemo/radiosensitizing and antineoplastic activites. + Upon oral administration, DNA-PK inhibitor AZD7648 selectively targets, binds + to and inhibits the activity of DNA-PK, thereby interfering with the non-homologous + end joining (NHEJ) process and preventing repair of DNA double strand breaks + (DSBs) caused by ionizing radiation or chemotherapeutic treatment. This increases + chemo- and radiotherapy cytotoxicity leading to enhanced tumor cell death. AZD7648 + may also increase the effect of poly(ADP-ribose) polymerase (PARP) inhibitors + and may work as a monotherapy in tumors with high endogenous levels of DNA damage + resulting from defects in other DNA repair pathways. The enhanced ability of + tumor cells to repair DSBs plays a major role in the resistance of tumor cells + to chemo- and radiotherapy. DNA-PK plays a key role in the NHEJ pathway and + DSB repair. + termDef: + term: >- + DNA-PK inhibitor AZD7648 + source: NCIt + cde_id: C168692 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168692" + term_id: C168692 + term_version: 20.10d + +dnapkpi3kdelta_inhibitor_br101801: + common: + description: >- + An orally bioavailable inhibitor of phosphoinositide 3-kinase delta (PI3-kinase + subunit delta; PI3K-delta; PI3Kdelta) and DNA-dependent protein kinase (DNA-PK), + with potential antineoplastic and immunomodulating activities. Upon oral administration, + the DNA-PK/PI3K-delta inhibitor BR101801 inhibits the activity of both PI3K-delta + and DNA-PK. This prevents PI3K-mediated signaling pathways and may lead to the + inhibition of cancer cell growth in PI3K-overexpressing tumor cells. Specifically, + since PI3K regulates c-myc expression, inhibition of PI3K signaling may lead + to a decrease in proliferation of c-myc-expressing tumor cells. Also, by inhibiting + the activity of DNA-PK, this agent interferes with the non-homologous end joining + (NHEJ) process and prevents the repair of DNA double strand breaks (DSBs) caused + by ionizing radiation or chemotherapeutic treatment. This increases chemo- and + radiotherapy cytotoxicity by inhibiting the ability of tumor cells to repair + damaged DNA. The PI3K pathway is upregulated in a variety of tumors and plays + an important role in regulating cancer cell proliferation, growth, and survival. + DNA-PK is activated upon DNA damage and plays a key role in repairing double-stranded + DNA breaks. The enhanced ability of tumor cells to repair DSBs plays a major + role in the resistance of tumor cells to chemo- and radiotherapy. In addition, + BR101801 is able to decrease Tregs and increase CD8 lymphocytes. + termDef: + term: >- + DNA-PK/PI3K-delta Inhibitor BR101801 + source: NCIt + cde_id: C172111 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172111" + term_id: C172111 + term_version: 20.10d + +dnm2: + common: + description: >- + This gene plays a role in both GTP hydrolysis and microtubule organization. + termDef: + term: >- + DNM2 Gene + source: NCIt + cde_id: C102796 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102796" + term_id: C102796 + term_version: 20.10d + +dnmt1_inhibitor_ntx301: + common: + description: >- + An orally bioavailable inhibitor of human DNA methyltransferase 1 (DNMT1), with + potential antineoplastic activity. Upon oral administration, DNMT1 inhibitor + NTX-301 targets ad binds to DNMT1, thereby inhibiting the activity of DNMT1. + This may prevent DNA methylation, induce DNA hypomethylation, and activate tumor + suppressor genes silenced by hypermethylation. This may inhibit tumor cell proliferation. + DNMT1, a member of the DNA methyltransferase (DNMT) family, plays an important + role in maintaining the DNA methylation pattern. Dysregulation of DNMT1 has + been associated with a number of cancers. + termDef: + term: >- + DNMT1 Inhibitor NTX-301 + source: NCIt + cde_id: C174424 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174424" + term_id: C174424 + term_version: 20.10d + +dnmt3a: + common: + description: >- + This gene is involved in epigenetic modification of DNA. + termDef: + term: >- + DNMT3A Gene + source: NCIt + cde_id: C73652 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73652" + term_id: C73652 + term_version: 20.10d + +dociparstat_sodium: + common: + description: >- + A heparin derivative in which the 2-O and 3-O sulfate groups of heparin are + removed and that lacks anticoagulant activity, with potential anti-inflammatory, + immodulatory and antineoplastic activities. Upon administration, dociparstat + sodium binds to both chemokine stromal cell-derived factor 1 (SDF-1 or CXCL12) + and CXC chemokine receptor 4 (CXCR4). This prevents the interaction of CXCL12 + with CXCR4, blocks CXCR4 activation, and may result in decreased proliferation + and migration in CXCR4-overexpressing tumor cells. In addition, inhibition of + CXCL12/CXCR4 interaction may induce mobilization of hematopoietic cells from + the bone marrow into the blood. In addition, dociparstat sodium prevents the + interaction of the receptor for advanced glycation end-products (RAGE) with + its ligands, including advanced glycation end-products (AGEs), Mac-1(CD11b/CD18), + the nuclear pro-inflammatory protein high mobility group box protein-1 (HMGB-1), + carboxymethyl lysine-bovine serum albumin (CML-BSA) and members of the S100 + calgranulin family. In addition, this agent inhibits the enzymes heparanase, + cathepsin G, and human leukocyte elastase, which are involved in inflammation + and metastasis. Altogether, this may inhibit tumor cell invasiveness and metastasis. + Dociparstat sodium also binds to platelet factor 4 (PF4 or CXCL4) and may prevent + PF4's inhibitory effect on platelet production. This may increase platelet production. + Unlike heparin, this agent does not induce heparin-induced thrombocytopenia + (HIT). RAGE, a receptor belonging to the immunoglobulin superfamily, plays a + key role in inflammation and is overexpressed in a variety of cancers. CXCR4 + is a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family + that plays an important role in chemotaxis, chemoresistance and angiogenesis, + and is upregulated in several tumor cell types. The interaction between CXCL12/CXCR4 + induces retention of hematopoietic cells in the bone marrow. + termDef: + term: >- + Dociparstat sodium + source: NCIt + cde_id: C99130 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99130" + term_id: C99130 + term_version: 20.10d + +dome_of_bladder: + common: + description: >- + The upper, convex surface of the bladder. + termDef: + term: >- + Dome of the Bladder + source: NCIt + cde_id: C12332 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12332" + term_id: C12332 + term_version: 20.05a + +domestic_partner: + common: + description: >- + Indicates a person who is a member of an unmarried couple, including same sex + couples, living together in longstanding relationships, that are registered + or unregistered. + termDef: + term: >- + Domestic Partnership + source: NCIt + cde_id: C53262 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53262" + term_id: C53262 + term_version: 19.12e + +dominica: + common: + description: >- + An island between the Caribbean Sea and the North Atlantic Ocean, south of Guadeloupe + and north of Martinique. + termDef: + term: >- + Dominica + source: NCIt + cde_id: C16519 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16519" + term_id: C16519 + term_version: 19.12e + +dominican_republic: + common: + description: >- + A country comprising the eastern two-thirds of the island of Hispaniola, between + the Caribbean Sea and the North Atlantic Ocean, east of Haiti. + termDef: + term: >- + Dominican Republic + source: NCIt + cde_id: C16520 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16520" + term_id: C16520 + term_version: 19.12e + +dostarlimab: + common: + description: >- + A humanized monoclonal antibody directed against the negative immunoregulatory + human cell surface receptor programmed cell death 1 (PD-1; programmed death-1), + with potential immune checkpoint inhibitory and antineoplastic activities. Upon + administration, dostarlimab binds to and inhibits PD-1 and its downstream signaling + pathways. This may restore immune function through the activation of T-cells. + PD-1, a transmembrane protein in the Ig superfamily expressed on T-cells, functions + as an immune checkpoint protein that negatively regulates T-cell activation + and T-cell-mediated immune responses when activated by its ligands programmed + cell death receptor ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role + in tumor evasion from host immunity. + termDef: + term: >- + Dostarlimab + source: NCIt + cde_id: C126799 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126799" + term_id: C126799 + term_version: 20.10d + +downstream_gene_variant: + common: + description: >- + Any gene mutation that occurs in the sequences downstream from a coding region + of interest. + termDef: + term: >- + 3' Flank Mutation + source: NCIt + cde_id: C63431 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63431" + term_id: C63431 + term_version: 20.10d + +doxorubicin_prodrugprodrugactivating_biomaterial_sq3370: + common: + description: >- + A formulation consisting of SQL70, a prodrug-activating biomaterial, and SQP33, + a prodrug of the anthracycline antineoplastic antibiotic doxorubicin, with potential + antineoplastic activity. Upon administration of SQ3370, which consists of the + injection of SQL70 at the tumor site followed by the intravenous administration + of SQ3370, the prodrug SQP33 binds to, through an as of yet not identifiable + mechanism, to SQL70 at the tumor site. After binding, doxorubicin is released + over a period of days, intercalates into DNA and interacts with topoisomerase + II. This leads to an inhibition of DNA replication and repair, and prevents + RNA and protein synthesis. Compared to the systemic administration of doxorubicin + alone, SQ3370 may allow for higher and sustained delivery of active doxorubicin + directly to the tumor, which may increase its efficacy and limit its off-site, + systemic toxicity. + termDef: + term: >- + Doxorubicin Prodrug/Prodrug-activating Biomaterial SQ3370 + source: NCIt + cde_id: C167221 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167221" + term_id: C167221 + term_version: 20.10d + +drinker: + common: + description: >- + An individual who drinks at least once per week with regularity. + termDef: + term: >- + Drinker + source: NCIt + cde_id: C126383 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126383" + term_id: C126383 + term_version: 19.12e + +drosha: + common: + description: >- + This gene plays a role in the processing of microRNA in the nucleus. + termDef: + term: >- + DROSHA Gene + source: NCIt + cde_id: C25955 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25955" + term_id: C25955 + term_version: 20.10d + +dtrmwxhs12everolimuspomalidomide_combination_agent_dtrm555: + common: + description: >- + An orally bioavailable combination of DTRMWXHS-12, a Bruton's tyrosine kinase + (BTK) inhibitor, everolimus, a mammalian Target of Rapamycin (mTOR) inhibitor, + and pomalidomide, an immunomodulatory drug (IMiD), that may be used for the + treatment of B-cell malignancies. Upon oral administration of DTRM-555, the + DTRMWXHS-12 component inhibits the activity of BTK and prevents the activation + of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell + activation and BTK-mediated activation of downstream survival pathways, and + leads to an inhibition of the growth of malignant B-cells that overexpress BTK. + BTK plays an important role in the development, activation, signaling, proliferation + and survival of B-lymphocytes. The everolimus component binds to the immunophilin + FK Binding Protein-12 (FKBP-12) to generate a complex that binds to and inhibits + the activation of mTOR, a key regulatory kinase. Upregulated in some tumors, + mTOR is a serine/threonine kinase involved in regulating cellular proliferation, + motility, and survival that is located downstream of the PI3K/Akt signaling + pathway. The pomalidomide component may inhibit TNF-alpha production, enhance + the activity of T cells and natural killer (NK) cells and enhance antibody-dependent + cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis, + promote cell cycle arrest in susceptible tumor cell populations, and stimulate + erythropoiesis. The combination of a BTK inhibitor, an mTOR inhibitor and an + IMiD may work synergistically to kill malignant B-cells and prevent drug resistance. + termDef: + term: >- + DTRMWXHS-12/Everolimus/Pomalidomide Combination Agent DTRM-555 + source: NCIt + cde_id: C173999 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173999" + term_id: C173999 + term_version: 20.10d + +duct_adenocarcinoma_nos: + common: + description: >- + A breast carcinoma arising from the ducts. While ductal carcinomas can arise + at other sites, this term is universally used to refer to carcinomas of the + breast. Ductal carcinomas account for about two thirds of all breast cancers. Two + types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) + and invasive ductal carcinoma. The latter often spreads to the axillary lymph + nodes and other anatomic sites. The two forms of ductal carcinoma often coexist. + termDef: + term: >- + Ductal Breast Carcinoma + source: NCIt + cde_id: C4017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4017" + term_id: C4017 + term_version: 20.05a + +duct_adenoma_nos: + common: + description: >- + An intraluminal papillary epithelial neoplasm arising within the ducts. Representative + examples are the intraductal breast papilloma and the salivary gland intraductal + papilloma. + termDef: + term: >- + Intraductal Papilloma + source: NCIt + cde_id: C3785 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3785" + term_id: C3785 + term_version: 20.05a + +duct_carcinoma_nos: + common: + description: >- + A breast carcinoma arising from the ducts. While ductal carcinomas can arise + at other sites, this term is universally used to refer to carcinomas of the + breast. Ductal carcinomas account for about two thirds of all breast cancers. Two + types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) + and invasive ductal carcinoma. The latter often spreads to the axillary lymph + nodes and other anatomic sites. The two forms of ductal carcinoma often coexist. + termDef: + term: >- + Ductal Breast Carcinoma + source: NCIt + cde_id: C4017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4017" + term_id: C4017 + term_version: 20.05a + +duct_cell_carcinoma: + common: + description: >- + A breast carcinoma arising from the ducts. While ductal carcinomas can arise + at other sites, this term is universally used to refer to carcinomas of the + breast. Ductal carcinomas account for about two thirds of all breast cancers. Two + types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) + and invasive ductal carcinoma. The latter often spreads to the axillary lymph + nodes and other anatomic sites. The two forms of ductal carcinoma often coexist. + termDef: + term: >- + Ductal Breast Carcinoma + source: NCIt + cde_id: C4017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4017" + term_id: C4017 + term_version: 20.05a + +ductal_carcinoma_cribriform_type: + common: + description: >- + A carcinoma characterized by the presence of a cribriform architectural pattern. + Representative examples include the intraductal cribriform breast carcinoma + and invasive cribriform breast carcinoma. + termDef: + term: >- + Cribriform Carcinoma + source: NCIt + cde_id: C3680 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3680" + term_id: C3680 + term_version: 20.05a + +ductal_carcinoma_in_situ_cribriform_type: + common: + description: >- + A ductal carcinoma in situ of the breast characterized by the presence of a + cribriform architectural pattern. + termDef: + term: >- + Intraductal Cribriform Breast Adenocarcinoma + source: NCIt + cde_id: C5138 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5138" + term_id: C5138 + term_version: 20.05a + +ductal_carcinoma_in_situ_nos: + common: + description: >- + A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There + is no evidence of invasion of the basement membrane. Currently, it is classified + into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade + DCIS. In this classification the DCIS grade is defined by a combination of nuclear + grade, architectural growth pattern and presence of necrosis. The size of the + lesion as well as the grade and the clearance margins play a major role in dictating + the most appropriate therapy for DCIS. + termDef: + term: >- + Ductal Breast Carcinoma In Situ + source: NCIt + cde_id: C2924 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2924" + term_id: C2924 + term_version: 20.05a + +ductal_carcinoma_in_situ_papillary: + common: + description: >- + A non-invasive breast adenocarcinoma located in a distended duct. It is characterized + by the presence of papillary structures with fibrovascular stalks. In the absence + of ductal carcinoma in situ or invasive carcinoma in adjacent tissues, the prognosis + is usually favorable. + termDef: + term: >- + Intraductal Papillary Breast Carcinoma + source: NCIt + cde_id: C4190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4190" + term_id: C4190 + term_version: 20.05a + +ductal_carcinoma_nos: + common: + description: >- + A breast carcinoma arising from the ducts. While ductal carcinomas can arise + at other sites, this term is universally used to refer to carcinomas of the + breast. Ductal carcinomas account for about two thirds of all breast cancers. Two + types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) + and invasive ductal carcinoma. The latter often spreads to the axillary lymph + nodes and other anatomic sites. The two forms of ductal carcinoma often coexist. + termDef: + term: >- + Ductal Breast Carcinoma + source: NCIt + cde_id: C4017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4017" + term_id: C4017 + term_version: 20.05a + +ductal_intraepithelial_neoplasia_3: + common: + description: >- + A ductal carcinoma in situ characterized by the presence of neoplastic cells + with severe dysplasia and the formation of micropapillary, cribriform, or solid + patterns. The nuclei show marked pleomorphism and have prominent nucleoli. Mitotic + activity is usually present. There is comedo-type of necrosis present in the + ducts. The necrotic debris is surrounded by pleomorphic malignant cells. + termDef: + term: >- + High Grade Ductal Breast Carcinoma In Situ + source: NCIt + cde_id: C7949 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7949" + term_id: C7949 + term_version: 20.05a + +ductal_papilloma: + common: + description: >- + An intraluminal papillary epithelial neoplasm arising within the ducts. Representative + examples are the intraductal breast papilloma and the salivary gland intraductal + papilloma. + termDef: + term: >- + Intraductal Papilloma + source: NCIt + cde_id: C3785 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3785" + term_id: C3785 + term_version: 20.05a + +dudisease_unchanged: + common: + description: >- + In an unchanged or similar condition. + termDef: + term: >- + About The Same + source: NCIt + cde_id: C71687 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71687" + term_id: C71687 + term_version: 20.05a + +duodenum: + common: + description: >- + A jointed tube 25-30 cm long that connects the stomach to the jejunum. + termDef: + term: >- + Duodenum + source: NCIt + cde_id: C12263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12263" + term_id: C12263 + term_version: 20.05a + +duplication: + common: + description: >- + Generation of an extra copy of a particular gene in the genome. A gene duplication + abnormality may occur by gene amplification, random breakage and reunion, retrotransposition + or unequal crossing-over at meiosis. A gene duplication abnormality can be either + heritable or somatic. + termDef: + term: >- + Gene Duplication Abnormality + source: NCIt + cde_id: C45582 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45582" + term_id: C45582 + term_version: 20.10d + +dux4l1: + common: + description: >- + Human DUX4L1 gene is located in the vicinity of 4q35 and is approximately 2 + kb in length. The product is a processed pseudogene that produces an RNA transcript, + but does not encode a protein product. This gene is within a D4Z4 repeat array; + contraction of this macrosatellite repeat is associated with facioscapulohumeral + muscular dystrophy (FSHD). + termDef: + term: >- + DUX4L1 Gene + source: NCIt + cde_id: C124048 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124048" + term_id: C124048 + term_version: 20.10d + +dysembryoplastic_neuroepithelial_tumor: + common: + description: >- + A benign glial-neuronal neoplasm. It is usually supratentorial, located in the + cortex. It occurs in children and young adults with a long-standing history + of partial seizures. A histologic hallmark of this tumor is the 'specific glioneuronal + element', characterized by columns, made up of bundles of axons, oriented perpendicularly + to the cortical surface. (Adapted from WHO) + termDef: + term: >- + Dysembryoplastic Neuroepithelial Tumor + source: NCIt + cde_id: C9505 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9505" + term_id: C9505 + term_version: 20.05a + +dysgerminoma: + common: + description: >- + A malignant germ cell tumor characterized by the presence of a monotonous primitive + germ cell population. The neoplastic cells form aggregates and have an abundant + pale cytoplasm and uniform nuclei. The aggregates of the germ cells are separated + by fibrous septa which contain inflammatory cells, mostly T-lymphocytes. It + arises primarily in the ovaries, but can occur both primarily and secondarily + at other sites, particularly the central nervous system. It responds to chemotherapy + and radiotherapy. Its prognosis is related to the tumor stage. + termDef: + term: >- + Dysgerminoma + source: NCIt + cde_id: C2996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2996" + term_id: C2996 + term_version: 20.05a + +dysplastic_gangliocytoma_of_cerebellum_lhermitteduclos: + common: + description: >- + A benign, WHO grade I cerebellar mass, which occurs in young adults and is composed + of dysplastic ganglion cells. It is the major CNS manifestation of Cowden disease, + an autosomal dominant condition that causes a variety of hamartomas and neoplasms. + termDef: + term: >- + Dysplastic Cerebellar Gangliocytoma + source: NCIt + cde_id: C8419 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8419" + term_id: C8419 + term_version: 20.05a + +dysplastic_nevus: + common: + description: >- + Solitary or multiple, slightly raised pigmented melanocytic lesions with irregular + borders, usually measuring more than 0.6cm in greatest dimension. Morphologically, + there is melanocytic atypia and the differential diagnosis from melanoma may + be difficult. Patients are at an increased risk for the development of melanoma. + termDef: + term: >- + Dysplastic Nevus + source: NCIt + cde_id: C3694 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3694" + term_id: C3694 + term_version: 20.05a + +ebf1: + common: + description: >- + This gene plays a role in transcriptional activation. + termDef: + term: >- + EBF1 Gene + source: NCIt + cde_id: C80023 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80023" + term_id: C80023 + term_version: 20.10d + +ebv_positive_diffuse_large_bcell_lymphoma_of_the_elderly: + common: + description: >- + A diffuse large B-cell lymphoma originally described in patients older than + 50 years but it has been increasingly recognized in younger patients. Epstein-Barr + virus is present in all cases. There is no known history of immunodeficiency + or prior lymphoma. + termDef: + term: >- + EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified + source: NCIt + cde_id: C80281 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80281" + term_id: C80281 + term_version: 20.05a + +ecchondroma: + common: + description: >- + A common, benign cartiliginous neoplasm arising from the metaphysis of bone. + The tumor grows on the surface of the bone; it may be pedunculated or sessile. + It is characterized by the presence of chondrocytes, a cartilage cap, and a + fibrous perichondrium that extends to the periosteum of the bone. In some cases, + there is deletion of 8q24.1 chromosome locus. + termDef: + term: >- + Osteochondroma + source: NCIt + cde_id: C3295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3295" + term_id: C3295 + term_version: 20.05a + +ecchondrosis: + common: + description: >- + An autosomal dominant neoplastic chondrogenic process affecting multiple sites. + It is caused by mutations in the EXT1 or EXT2 genes. Grossly and microscopically, + the lesions resemble an osteochondroma. + termDef: + term: >- + Multiple Osteochondromas + source: NCIt + cde_id: C53457 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53457" + term_id: C53457 + term_version: 20.05a + +eccrine_acrospiroma: + common: + description: >- + A benign epithelial neoplasm arising from the sweat glands. Variants include + the clear cell and nodular hidradenoma. + termDef: + term: >- + Hidradenoma + source: NCIt + cde_id: C7563 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7563" + term_id: C7563 + term_version: 20.05a + +eccrine_cystadenoma: + common: + description: >- + A benign sweat gland cystic lesion that arises from the dermis. It is lined + by a thin epithelial layer of cells with a slightly eosinophilic cytoplasm. + termDef: + term: >- + Eccrine Hidrocystoma + source: NCIt + cde_id: C7565 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7565" + term_id: C7565 + term_version: 20.05a + +eccrine_dermal_cylindroma: + common: + description: >- + A benign sweat gland neoplasm usually occurring in the scalp or the face. It + may present as solitary or multiple papular or nodular lesions. It may be a + sporadic lesion or part of Brooke-Spiegler syndrome. It arises from the dermis + and has a multinodular, circumscribed appearance. The nodules contain basaloid + cells with small, dark nuclei. Complete excision is usually curative. + termDef: + term: >- + Cylindroma + source: NCIt + cde_id: C27094 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27094" + term_id: C27094 + term_version: 20.05a + +eccrine_papillary_adenocarcinoma: + common: + description: >- + An adenocarcinoma arising from the sweat glands. Most cases present as nodular + lesions on the digits, usually in the hands. It is characterized by the presence + of epithelial cells in the dermis forming nodules. Cystic structures containing + papillary projections are also present. It may recur and metastasize, most commonly + to the lungs. + termDef: + term: >- + Digital Papillary Adenocarcinoma + source: NCIt + cde_id: C27534 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27534" + term_id: C27534 + term_version: 20.05a + +eccrine_papillary_adenoma: + common: + description: >- + A benign neoplasm arising from the sweat glands. It is characterized by the + presence of eccrine ducts in the dermis containing intraluminal papillary projections. + termDef: + term: >- + Papillary Eccrine Adenoma + source: NCIt + cde_id: C4173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4173" + term_id: C4173 + term_version: 20.05a + +eccrine_poroma: + common: + description: >- + A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. + It usually presents as a solitary, dome-shaped papule, nodule, or plaque on + acral sites. It is characterized by a proliferation of uniform basaloid cells + in the dermis and it is associated with the presence of focal ductal and cystic + structures. Complete excision is curative. + termDef: + term: >- + Poroma + source: NCIt + cde_id: C27273 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27273" + term_id: C27273 + term_version: 20.05a + +eccrine_poroma_malignant: + common: + description: >- + A carcinoma with eccrine differentiation arising from the sweat glands. It may + arise de novo or as a malignant transformation of a pre-existing poroma. It + usually grows in the legs, buttocks, feet, and trunk and usually presents as + an ulcerative plaque. It is characterized by the presence of intraepidermal + and dermal nests of malignant epithelial cells. It may recur after excision + and metastasize to the lymph nodes and less frequently to distal anatomic sites. + termDef: + term: >- + Porocarcinoma + source: NCIt + cde_id: C5560 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5560" + term_id: C5560 + term_version: 20.05a + +eccrine_spiradenoma: + common: + description: >- + A benign epithelial neoplasm with eccrine or apocrine differentiation, arising + from the sweat glands. It usually presents as a solitary, well circumscribed, + firm nodule in the face and upper trunk. It is characterized by the presence + of basaloid cells forming nodules in the dermis. Cases of carcinoma arising + from long standing spiradenomas have been reported. + termDef: + term: >- + Spiradenoma + source: NCIt + cde_id: C4170 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4170" + term_id: C4170 + term_version: 20.05a + +ecl_cell_carcinoid_malignant: + common: + description: >- + A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) arising + from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like + type granules in the neoplastic cells. + termDef: + term: >- + Enterochromaffin-Like Cell Neuroendocrine Tumor G1 + source: NCIt + cde_id: C27252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27252" + term_id: C27252 + term_version: 20.05a + +ecl_cell_carcinoid_nos: + common: + description: >- + A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) arising + from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like + type granules in the neoplastic cells. + termDef: + term: >- + Enterochromaffin-Like Cell Neuroendocrine Tumor G1 + source: NCIt + cde_id: C27252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27252" + term_id: C27252 + term_version: 20.05a + +ect2l: + common: + description: >- + This gene may be involved in guanine nucleotide exchange. + termDef: + term: >- + ECT2L Gene + source: NCIt + cde_id: C101452 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101452" + term_id: C101452 + term_version: 20.10d + +ectomesenchymoma: + common: + description: >- + An aggressive malignant mesenchymal neoplasm of the nervous system or soft tissues. + It is characterized by the presence of a sarcomatous component (most often rhabdomyosarcoma) + and a ganglionic or a neuroectodermal component. + termDef: + term: >- + Ectomesenchymoma + source: NCIt + cde_id: C4716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4716" + term_id: C4716 + term_version: 20.05a + +ectopic_hamartomatous_thymoma: + common: + description: >- + A benign, well-circumscribed tumor of the neck occurring in adults. It is characterized + by the presence of spindle cells, epithelial islands, and adipose tissue. There + is no evidence of thymic origin or differentiation, despite the use of the term + thymoma in the literature. + termDef: + term: >- + Ectopic Hamartomatous Thymoma + source: NCIt + cde_id: C53595 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53595" + term_id: C53595 + term_version: 20.05a + +ecuador: + common: + description: >- + A country in western South America, bordering the Pacific Ocean at the Equator, + between Colombia and Peru. + termDef: + term: >- + Ecuador + source: NCIt + cde_id: C16528 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16528" + term_id: C16528 + term_version: 19.12e + +edicotinib: + common: + description: >- + A small molecule and orally available inhibitor of colony-stimulating factor-1 + receptor (CSF1R; FMS) with potential antineoplastic activity. Edicotinib blocks + the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing + autophosphorylation of FMS. As a result, unphosphorylated FMS can not activate + FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation + in FMS-overexpressed tumor cells. FMS, a tyrosine kinase receptor, is overexpressed + in certain tumor cell types and plays an essential role in macrophage differentiation, + recruitment, and activation as well as the regulation of cell proliferation. + termDef: + term: >- + Edicotinib + source: NCIt + cde_id: C101519 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101519" + term_id: C101519 + term_version: 20.10d + +edodekin_alfa: + common: + description: >- + A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with + potential antineoplastic activity. Edodekin alfa binds to and activates its + cell-surface receptor, stimulating the production of interferon-gamma (IFN) + which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits + tumor angiogenesis. (NCI04) + termDef: + term: >- + Edodekin alfa + source: NCIt + cde_id: C1380 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1380" + term_id: C1380 + term_version: 20.10d + +eed: + common: + description: >- + This gene plays a role in the negative regulation of transcription. + termDef: + term: >- + EED Gene + source: NCIt + cde_id: C101721 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101721" + term_id: C101721 + term_version: 20.10d + +eftozanermin_alfa: + common: + description: >- + A fusion protein composed of a tumor necrosis factor (TNF)-related apoptosis-inducing + ligand (TRAIL) receptor agonist consisting of six receptor binding domains (RBDs) + of TRAIL fused to the Fc-domain of a human immunoglobulin G1 (IgG1) antibody, + with potential pro-apoptotic and antineoplastic activities. Upon administration + of eftozanermin alfa, this fusion protein binds to TRAIL-receptors, pro-apoptotic + death receptors (DRs) TRAIL-R1 (death receptor 4; DR4) and TRAIL-R2 (death receptor + 5; DR5), expressed on tumor cells, thereby inducing tumor cell apoptosis. ABBV-621 + is designed to maximize receptor clustering for optimal efficacy. TRAIL, a member + of the TNF superfamily of cytokines, plays a key role in the induction of apoptosis + through TRAIL-mediated death receptor pathways. + termDef: + term: >- + Eftozanermin Alfa + source: NCIt + cde_id: C146854 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146854" + term_id: C146854 + term_version: 20.10d + +egfr: + common: + description: >- + This gene is involved in the epidermal growth factor signal transduction pathway. + termDef: + term: >- + EGFR Gene + source: NCIt + cde_id: C17757 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17757" + term_id: C17757 + term_version: 20.10d + +egfr_inhibitor_ty9591: + common: + description: >- + An orally available inhibitor of epidermal growth factor receptor (EGFR), including + activating mutations, with potential antineoplastic activity. Upon administration, + the EGFR inhibitor TY-9591 binds to and inhibits EGFR activating mutations, + including the resistance mutation T790M, which prevents EGFR mutant-mediated + signaling and leads to cell death in EGFR mutant-expressing tumor cells. EGFR, + a receptor tyrosine kinase mutated in many tumor cell types, plays a key role + in tumor cell proliferation and tumor vascularization. + termDef: + term: >- + EGFR Inhibitor TY-9591 + source: NCIt + cde_id: C175445 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175445" + term_id: C175445 + term_version: 20.10d + +egfr_mutantselective__inhibitor_tqb3804: + common: + description: >- + A fourth-generation, orally bioavailable, mutant-selective, epidermal growth + factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon + oral administration, EGFR mutant-selective inhibitor TQB3804 binds to and inhibits + the activity of mutant forms of EGFR, including the C797S EGFR mutant, thereby + preventing EGFR-mediated signaling. This may both induce cell death and inhibit + tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase + mutated in many tumor cell types, plays a key role in tumor cell proliferation + and tumor vascularization. TQB3804 inhibits mutated forms of EGFR including + C797S, which prevents covalent bond formation with third-generation EGFR inhibitor + osimertinib leading to drug resistance. TQB3804 may have enhanced anti-tumor + effects in tumors with C797S-mediated resistance when compared to other EGFR + tyrosine kinase inhibitors. + termDef: + term: >- + EGFR Mutant-selective Inhibitor TQB3804 + source: NCIt + cde_id: C173415 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173415" + term_id: C173415 + term_version: 20.10d + +egfregfrviii_inhibitor_wsd0922fu: + common: + description: >- + A blood-brain-barrier (BBB) penetrable selective inhibitor of epidermal growth + factor receptor (EGFR) and various EGFR mutations, including but not limited + to the EGFR variant III (EGFRvIII) mutant form, with potential antineoplastic + activity. Upon administration of EGFR/EGFRvIII inhibitor WSD0922-FU, this agent + is able to penetrate the BBB and specifically targets, binds to and inhibits + EGFR and specific EGFR mutations, which prevents EGFR/EGFR mutant-mediated signaling + and leads to cell death in EGFR/EGFR mutant-expressing tumor cells. Compared + to other EGFR inhibitors that are not able to penetrate the BBB, WSD0922-FU + may have therapeutic benefits in brain tumors, such as glioblastoma (GBM) and + metastatic CNS tumors. EGFR, a receptor tyrosine kinase (RTK) that is mutated + in many tumor cell types, plays a key role in tumor cell proliferation and survival. + termDef: + term: >- + EGFR/EGFRvIII Inhibitor WSD0922-FU + source: NCIt + cde_id: C165778 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165778" + term_id: C165778 + term_version: 20.10d + +egfrher2_inhibitor_dzd9008: + common: + description: >- + An orally available, irreversible, dual kinase inhibitor of epidermal growth + factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) that + shows similar activity against certain activating mutations, including exon + 20 insertions (exon20ins), with potential antineoplastic activity. Upon oral + administration, EGFR/HER2 inhibitor DZD9008 binds to and inhibits EGFR and HER2, + which may result in the inhibition of tumor growth and angiogenesis, and tumor + regression in EGFR/HER2-expressing tumors. EGFR and HER2 are receptor tyrosine + kinases that play major roles in tumor cell proliferation and tumor vascularization. + In contrast to other agents active against exon20ins mutations, DZD9008 appears + to be more selective against mutated EGFR than wild-type (wt) EGFR. This may + lessen wtEGFR-related dose-limiting toxicity and may allow for the administration + of the desired therapeutic dose of DZD9008. + termDef: + term: >- + EGFR/HER2 Inhibitor DZD9008 + source: NCIt + cde_id: C167205 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167205" + term_id: C167205 + term_version: 20.10d + +egfrtgfb_fusion_monoclonal_antibody_bca101: + common: + description: >- + A bifunctional monoclonal antibody targeting both the receptor tyrosine kinase + epidermal growth factor receptor (EGFR) and the pro-inflammatory cytokine human + transforming growth factor beta (TGF-beta; TGFb), with potential antineoplastic + activity. Upon administration of EGFR/TGFb fusion monoclonal antibody BCA101, + the anti-EGFR moiety targets, binds to and prevents activation of EGFR-mediated + signaling. This leads to an inhibition of EGFR-dependent downstream pathways + and EGFR-dependent tumor cell proliferation and metastasis. The anti-TGFb moiety + targets and binds to TGFb, thereby preventing the activation of TGFb-mediated + signaling pathways. This may inhibit the proliferation of tumor cells in which + TGFb is overactivated. EGFR and TGFb, mutated and/or overexpressed on the surfaces + of various tumor cell types, play key roles in tumor cell proliferation and + progression. + termDef: + term: >- + EGFR/TGFb Fusion Monoclonal Antibody BCA101 + source: NCIt + cde_id: C173165 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173165" + term_id: C173165 + term_version: 20.10d + +egfrvegfrret_inhibitor_ha12128: + common: + description: >- + An orally available inhibitor of the epidermal growth factor receptor (EGFR), + the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET) + and vascular endothelial growth factor receptor (VEGFR), with potential anti-angiogenic + and antineoplastic activities. Upon oral administration of HA121-28, this agent + targets, binds to and inhibits the activity of EGFR, RET and VEGFR. This prevents + EGFR-, RET- and VEGFR-mediated signaling, and may lead to the induction of apoptosis + and inhibition of tumor growth in EGFR-, RET- and VEGFR-overexpressing cells. + EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key + role in tumor cell proliferation and tumor vascularization. Dysregulation of + RET activity plays a key role in the development and progression of a variety + of cancers. Expression of VEGFR is upregulated in a variety of tumor cell types; + it plays a key role in the migration, proliferation and survival of endothelial + cells, microvessel formation, the inhibition of tumor cell proliferation, and + tumor cell death. + termDef: + term: >- + EGFR/VEGFR/RET Inhibitor HA121-28 + source: NCIt + cde_id: C173436 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173436" + term_id: C173436 + term_version: 20.10d + +egypt: + common: + description: >- + A country in northern Africa, bordering the Mediterranean Sea, east of Libya + and north of Sudan. + termDef: + term: >- + Egypt + source: NCIt + cde_id: C16530 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16530" + term_id: C16530 + term_version: 19.12e + +eif1ax: + common: + description: >- + This gene is involved in translation initiation and efficiency. + termDef: + term: >- + EIF1AX Gene + source: NCIt + cde_id: C131315 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131315" + term_id: C131315 + term_version: 20.10d + +eif3e: + common: + description: >- + This gene is involved in the initiation and regulation of protein translation. + termDef: + term: >- + EIF3E Gene + source: NCIt + cde_id: C18347 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18347" + term_id: C18347 + term_version: 20.10d + +eif4a2: + common: + description: >- + This gene is involved in translation initiation. + termDef: + term: >- + EIF4A2 Gene + source: NCIt + cde_id: C97467 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97467" + term_id: C97467 + term_version: 20.10d + +el_salvador: + common: + description: >- + A country in Central America, bordering the North Pacific Ocean, between Guatemala + and Honduras. + termDef: + term: >- + El Salvador + source: NCIt + cde_id: C16532 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16532" + term_id: C16532 + term_version: 19.12e + +elastofibroma: + common: + description: >- + A benign, slow-growing tumor arising from the soft tissues usually in the mid-thoracic + region of the elderly. It is characterized by the presence of paucicellular + collagenous tissue, adipocytes and a predominance of large coarse elastic fibers + arranged in globules. + termDef: + term: >- + Elastofibroma + source: NCIt + cde_id: C4245 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4245" + term_id: C4245 + term_version: 20.05a + +electrical_fire_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + during an electrical fire. + termDef: + term: >- + Electrical Fire Smoke Exposure + source: NCIt + cde_id: C164077 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164077" + term_id: C164077 + term_version: 19.12e + +electronic_cigarette: + common: + description: >- + A battery-powered electronic device designed to atomize a nicotine-containing + liquid solution for inhalation in a manner that simulates smoking a tobacco + cigarette. + termDef: + term: >- + Electronic Cigarette + source: NCIt + cde_id: C120482 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C120482" + term_id: C120482 + term_version: 19.12e + +electronic_cigarette_smoke_nos: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced by direct or nearby use of an electronic cigarette. + termDef: + term: >- + Electronic Cigarette Smoke Exposure + source: NCIt + cde_id: C164062 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164062" + term_id: C164062 + term_version: 19.12e + +elf3: + common: + description: >- + This gene is involved in the regulation of both transcription and epithelial + cell differentiation. It also plays a role in angiogenesis. + termDef: + term: >- + ELF3 Gene + source: NCIt + cde_id: C20899 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20899" + term_id: C20899 + term_version: 20.10d + +elf4: + common: + description: >- + This gene plays a role in both DNA binding and transcriptional activation. + termDef: + term: >- + ELF4 Gene + source: NCIt + cde_id: C97470 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97470" + term_id: C97470 + term_version: 20.10d + +elk4: + common: + description: >- + This gene is involved in the regulation of transcription. + termDef: + term: >- + ELK4 Gene + source: NCIt + cde_id: C97476 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97476" + term_id: C97476 + term_version: 20.10d + +ell: + common: + description: >- + This gene is involved in the modulation of transcription. + termDef: + term: >- + ELL Gene + source: NCIt + cde_id: C97516 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97516" + term_id: C97516 + term_version: 20.10d + +eln: + common: + description: >- + This gene is involved in the structure of the extracellular matrix. + termDef: + term: >- + ELN Gene + source: NCIt + cde_id: C75333 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75333" + term_id: C75333 + term_version: 20.10d + +embryonal_adenocarcinoma: + common: + description: >- + A non-seminomatous malignant germ cell tumor characterized by the presence of + large germ cells with abundant cytoplasm resembling epithelial cells, geographic + necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures + formation. It can arise from the testis, ovary, and extragonadal sites (central + nervous system and mediastinum). + termDef: + term: >- + Embryonal Carcinoma + source: NCIt + cde_id: C3752 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3752" + term_id: C3752 + term_version: 20.05a + +embryonal_carcinoma_infantile: + common: + description: >- + A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It + is the most common malignant germ cell tumor in the pediatric population. It + occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, + abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor + mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment + includes: surgical resection, radiation, and chemotherapy. This tumor is very + responsive to chemotherapy regimens that include cisplatinum. + termDef: + term: >- + Yolk Sac Tumor + source: NCIt + cde_id: C3011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3011" + term_id: C3011 + term_version: 20.05a + +embryonal_carcinoma_nos: + common: + description: >- + A non-seminomatous malignant germ cell tumor characterized by the presence of + large germ cells with abundant cytoplasm resembling epithelial cells, geographic + necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures + formation. It can arise from the testis, ovary, and extragonadal sites (central + nervous system and mediastinum). + termDef: + term: >- + Embryonal Carcinoma + source: NCIt + cde_id: C3752 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3752" + term_id: C3752 + term_version: 20.05a + +embryonal_hepatoma: + common: + description: >- + A malignant liver neoplasm that occurs almost exclusively in infants, although + isolated cases in older children and adults have been reported. Grossly, hepatoblastoma + is solid, well circumscribed, and more often solitary than multiple. Microscopically, + most of the tumors are composed exclusively of immature hepatocytic elements. + About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated + or develop into bone or cartilage. The treatment of choice for hepatoblastoma + is surgical excision with adjuvant therapy. Liver transplantation is being increasingly + used as well. + termDef: + term: >- + Hepatoblastoma + source: NCIt + cde_id: C3728 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3728" + term_id: C3728 + term_version: 20.05a + +embryonal_rhabdomyosarcoma_nos: + common: + description: >- + A poorly circumscribed morphologic variant of rhabdomyosarcoma. It is characterized + by the presence of primitive skeletal muscle differentiation in any stage of + myogenesis. + termDef: + term: >- + Embryonal Rhabdomyosarcoma + source: NCIt + cde_id: C8971 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8971" + term_id: C8971 + term_version: 20.05a + +embryonal_sarcoma: + common: + description: >- + An aggressive malignant mesenchymal neoplasm that arises from the liver and + usually occurs in older children. It is composed of immature spindle, stellate, + polymorphous, and giant cells. + termDef: + term: >- + Undifferentiated (Embryonal) Sarcoma + source: NCIt + cde_id: C27096 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27096" + term_id: C27096 + term_version: 20.05a + +embryonal_teratoma: + common: + description: >- + A teratoma characterized by the presence of an extensive component of immature, + fetal-type tissues. + termDef: + term: >- + Immature Teratoma + source: NCIt + cde_id: C4286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4286" + term_id: C4286 + term_version: 20.05a + +embryonal_tumor_with_multilayered_rosettes_c19mcaltered: + common: + description: >- + An aggressive malignant embryonal neoplasm arising from the central nervous + system. It is characterized by the presence of multilayered rosettes formation + and the presence of amplification of the C19MC region on chromosome 19 (19q13.42). + termDef: + term: >- + Embryonal Tumor with Multilayered Rosettes, C19MC-Altered + source: NCIt + cde_id: C4915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4915" + term_id: C4915 + term_version: 20.05a + +embryonal_tumor_with_multilayered_rosettes_nos: + common: + description: >- + A central nervous system embryonal neoplasm characterized by the presence of + histological features consistent with embryonal tumor with multilayered rosettes + and absence of C19MC amplification. + termDef: + term: >- + Embryonal Tumor with Multilayered Rosettes, Not Otherwise Specified + source: NCIt + cde_id: C129499 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129499" + term_id: C129499 + term_version: 20.05a + +embryonal_tumor_with_rhabdoid_features: + common: + description: >- + A central nervous system embryonal neoplasm characterized by the presence of + histological features consistent with atypical teratoid/rhabdoid tumor and absence + of mutations of the INI1 gene or SMARCA4 (BRG1) gene. + termDef: + term: >- + Central Nervous System Embryonal Tumor with Rhabdoid Features + source: NCIt + cde_id: C129501 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129501" + term_id: C129501 + term_version: 20.05a + +embryonic_fluid: + common: + description: >- + Fluids surrounding or related to an embryo. + termDef: + term: >- + Embryonic Fluid + source: NCIt + cde_id: C13398 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13398" + term_id: C13398 + term_version: 20.10d + +embryonic_tissue: + common: + description: >- + Tissue that is formed during the embryonic stage of life of an organism. + termDef: + term: >- + Embryonic Tissue + source: NCIt + cde_id: C12950 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12950" + term_id: C12950 + term_version: 20.10d + +emibetuzumab: + common: + description: >- + A humanized IgG4 monoclonal antibody directed against human hepatocyte growth + factor receptor (HGFR or c-MET) with potential antineoplastic activity. Emibetuzumab + binds to c-MET, thereby preventing the binding of HGF to its receptor c-Met + and subsequent activation of the HGF/c-Met signaling pathway. This may result + in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase + overexpressed or mutated in many tumor cell types, plays a key role in cancer + cell growth, survival, angiogenesis, invasion, and metastasis. + termDef: + term: >- + Emibetuzumab + source: NCIt + cde_id: C95732 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95732" + term_id: C95732 + term_version: 20.10d + +eml4: + common: + description: >- + This gene may play a role in cytoskeletal assembly. + termDef: + term: >- + EML4 Gene + source: NCIt + cde_id: C71003 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71003" + term_id: C71003 + term_version: 20.10d + +enadenotucirevexpressing_fapcd3_bispecific_faptac_ng641: + common: + description: >- + An oncolytic adenoviral vector, a transgene-modified variant of enadenotucirev + (EnAd), that expresses a bi-specific T-cell activator molecule FAP-TAc together + with immune enhancer molecules C-X-C motif chemokine 9 (CXCL9), C-X-C motif + chemokine 10 (CXCL10) and interferon alpha (IFNalpha), with potential immunomodulating + and antineoplastic activities. Upon administration of NG-641, EnAd specifically + infects and replicates in tumor cells and not in normal, noncancerous tissue, + and selectively expresses FAP-TAc. The locally expressed FAP-TAc targets and + binds to both fibroblast activating protein (FAP) on cancer associated fibroblasts + (CAFs) and CD3 on T-cells. This leads to T-cell activation and T-cell mediated + killing of CAFs in tumor stroma. NG-641 also encodes the transgenes CXCL9, CXCL10 + and IFNalpha. The production of CXCL9, CXCL10 and IFNalpha leads to the recruitment + and further activation of T-cells, enhancing the overall immune response and + cancer cell killing. FAP, a cell surface glycoprotein, is overexpressed on tumor-associated + fibroblasts but minimally expressed on normal, healthy cells. + termDef: + term: >- + Enadenotucirev-expressing FAP/CD3 Bispecific FAP-TAc NG-641 + source: NCIt + cde_id: C168790 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168790" + term_id: C168790 + term_version: 20.10d + +encapsulated_papillary_carcinoma: + common: + description: >- + A typical papillary thyroid gland carcinoma that is totally surrounded by a + fibrous capsule, which may be intact or only focally infiltrated by tumor growth. + It accounts for about 10% of all cases of papillary thyroid gland carcinoma + and has an excellent prognosis. Regional nodal metastases may be present, but + bloodborne metastases are rare. The survival rate is nearly 100%. (WHO 2017) + termDef: + term: >- + Encapsulated Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C156034 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156034" + term_id: C156034 + term_version: 20.05a + +encapsulated_papillary_carcinoma_with_invasion: + common: + description: >- + A papillary carcinoma of the thyroid gland which is encapsulated and resembles + an encapsulated follicular neoplasm. Capsular invasion is present. The malignant + follicular cells display the nuclear features that characterize the papillary + adenocarcinomas of the thyroid gland. + termDef: + term: >- + Follicular Variant Thyroid Gland Papillary Carcinoma, Encapsulated Subtype + with Invasion + source: NCIt + cde_id: C66850 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66850" + term_id: C66850 + term_version: 20.05a + +encapsulated_rapamycin: + common: + description: >- + An orally bioavailable nanoparticle-based formulation composed of sub-micron + particles of the macrolide antibiotic rapamycin incorporated into a pH-sensitive + poly(methyl methacrylate) polymer, with potential immunomodulating and antineoplastic + activities. Upon oral administration of the encapsulated rapamycin, the nanoparticle + specifically delivers rapamycin at the tumor site. Rapamycin binds to the immunophilin + FK Binding Protein-12 (FKBP-12) to generate a complex that binds to and inhibits + the activation of the serine/threonine kinase mammalian target of rapamycin + (mTOR), a key regulatory kinase. This may suppress mTORC1 activity. In addition, + inhibition of mTOR may modulate central memory CD8 T cells, CD3+/CD56+ natural + killer (NK) cells and CD8 T-cell responses. This may kill tumor cells. Compared + to the administration of rapamycin alone, this formulation improves oral bioavailability + of rapamycin with more consistent rapamycin levels, thereby allowing for administration + of lower rapamycin dosage, which improves and minimizes rapamycin's toxicity. + Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating + cellular proliferation, motility, and survival that is located downstream of + the PI3K/Akt signaling pathway. + termDef: + term: >- + Encapsulated Rapamycin + source: NCIt + cde_id: C173879 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173879" + term_id: C173879 + term_version: 20.10d + +encelimab: + common: + description: >- + A humanized, immunoglobulin G4 (IgG4) monoclonal antibody directed against the + inhibitory receptor lymphocyte activation gene 3 protein (LAG3; LAG-3), with + potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,encelimab + binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) and blocks + its binding with major histocompatibility complex (MHC) class II molecules expressed + on tumor cells. This activates antigen-specific T-lymphocytes and enhances cytotoxic + T-cell-mediated tumor cell lysis, which leads to a reduction in tumor growth. + LAG3, a member of the immunoglobulin superfamily (IgSF), is expressed on various + immune cells, and negatively regulates both proliferation and activation of + T-cells. Its expression on TILs is associated with tumor-mediated immune suppression. + termDef: + term: >- + Encelimab + source: NCIt + cde_id: C142978 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142978" + term_id: C142978 + term_version: 20.10d + +enchondroma: + common: + description: >- + A common benign hyaline cartilage neoplasm arising in the intramedullary bone. It + is characterized by the presence of chondrocytes, low mitotic activity, and + in some cases, a nodular pattern and calcification. The small bones of the hands + and feet are the most frequently affected sites. + termDef: + term: >- + Enchondroma + source: NCIt + cde_id: C3007 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3007" + term_id: C3007 + term_version: 20.05a + +endemic: + common: + description: >- + A clinical variant of Burkitt lymphoma that occurs in equatorial Africa. The + Epstein-Barr virus has been detected in all patients. It is the most common + malignancy of childhood in this area. + termDef: + term: >- + Endemic Burkitt Lymphoma + source: NCIt + cde_id: C27122 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27122" + term_id: C27122 + term_version: 20.05a + +endocervical_adenocarcinoma_usual_type: + common: + description: >- + An adenocarcinoma that arises from the endocervix. It is the most common type + of endocervical adenocarcinoma. The neoplastic epithelium shows a pseudostratified + architecture and the malignant cells have enlarged, elongated, and hyperchromatic + nuclei. + termDef: + term: >- + Endocervical Adenocarcinoma, Usual Type + source: NCIt + cde_id: C127907 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127907" + term_id: C127907 + term_version: 20.05a + +endocervix: + common: + description: >- + The portion of the cervix which is lined by single columnar epithelium (mucosa). + termDef: + term: >- + Endocervix + source: NCIt + cde_id: C12309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12309" + term_id: C12309 + term_version: 20.05a + +endocrine_adenomatosis: + common: + description: >- + An autosomal dominant inherited neoplastic syndrome characterized by the development + of various endocrine neoplasms and abnormalities in various anatomic sites. + There are four types recognized: type 1 (MEN 1), caused by inactivation of the + tumor suppressor gene MEN-1, type 2A (MEN 2A), caused by mutation of the RET + gene, type 2B (MEN 2B) also caused by mutation of the RET gene, and type 4 (MEN + 4) caused by mutation of the CDKN1B gene. Patients with MEN 1 may develop hyperparathyroidism + and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell + neoplasms, and carcinoid tumors. Patients with MEN 2A develop medullary thyroid + carcinomas and may also develop pheochromocytomas and parathyroid gland hyperplasia. + Patients with MEN 2B develop medullary thyroid carcinomas and numerous neural + defects including neuromas. Patients with MEN 4 develop endocrine neoplasms, + particularly in the parathyroid glands, pituitary, and pancreas. + termDef: + term: >- + Multiple Endocrine Neoplasia + source: NCIt + cde_id: C6432 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6432" + term_id: C6432 + term_version: 20.05a + +endocrine_gland_nos: + common: + description: >- + Ductless glands that secrete substances which are released directly into the + circulation and which influence metabolism and other body functions. + termDef: + term: >- + Endocrine Gland + source: NCIt + cde_id: C12704 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12704" + term_id: C12704 + term_version: 20.05a + +endocrine_tumor_functioning_nos: + common: + description: >- + A hormone producing endocrine neoplasm, associated with a hormonal syndrome. + termDef: + term: >- + Functioning Endocrine Neoplasm + source: NCIt + cde_id: C94759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94759" + term_id: C94759 + term_version: 20.05a + +endodermal_sinus_tumor: + common: + description: >- + A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It + is the most common malignant germ cell tumor in the pediatric population. It + occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, + abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor + mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment + includes: surgical resection, radiation, and chemotherapy. This tumor is very + responsive to chemotherapy regimens that include cisplatinum. + termDef: + term: >- + Yolk Sac Tumor + source: NCIt + cde_id: C3011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3011" + term_id: C3011 + term_version: 20.05a + +endolymphatic_stromal_myosis: + common: + description: >- + An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, + and the ovary. It is characterized by the presence of oval to spindle-shape + cells that resemble the cells of the endometrial stroma, without evidence of + significant atypia and pleomorphism. Numerous small vessels are also present. + It is usually characterized by indolent growth and late recurrences. + termDef: + term: >- + Low Grade Endometrioid Stromal Sarcoma + source: NCIt + cde_id: C4263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4263" + term_id: C4263 + term_version: 20.05a + +endometrial_sarcoma_nos: + common: + description: >- + A malignant mesenchymal neoplasm that affects the uterine corpus, and rarely, + the ovaries, cervix, and vagina. In the uterine corpus it is classified as low + grade or high grade endometrial stromal sarcoma. In the remainder of the anatomic + sites it is classified as low grade endometrioid stromal sarcoma. + termDef: + term: >- + Endometrioid Stromal Sarcoma + source: NCIt + cde_id: C8973 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8973" + term_id: C8973 + term_version: 20.05a + +endometrial_stromal_nodule: + common: + description: >- + A non-infiltrating, benign mesenchymal neoplasm arising from the uterine corpus. + It is characterized by the presence of neoplastic cells that resemble the cells + of the proliferative phase of endometrial stroma and numerous thin-walled small + vessels. It usually presents with abnormal uterine bleeding and menorrhagia. + termDef: + term: >- + Endometrial Stromal Nodule + source: NCIt + cde_id: C4262 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4262" + term_id: C4262 + term_version: 20.05a + +endometrial_stromal_sarcoma_high_grade: + common: + description: >- + A rare, high grade sarcoma that arises from the endometrial stroma or myometrium + without a specific type of differentiation. It was previously also known as + high grade endometrial stromal sarcoma. In 2014, high grade endometrial stromal + sarcoma was reclassified and is currently considered a distinct and rare neoplasm. + Undifferentiated uterine sarcoma has a worse prognosis. + termDef: + term: >- + Uterine Corpus Undifferentiated Sarcoma + source: NCIt + cde_id: C8972 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8972" + term_id: C8972 + term_version: 20.05a + +endometrial_stromal_sarcoma_low_grade: + common: + description: >- + An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, + and the ovary. It is characterized by the presence of oval to spindle-shape + cells that resemble the cells of the endometrial stroma, without evidence of + significant atypia and pleomorphism. Numerous small vessels are also present. + It is usually characterized by indolent growth and late recurrences. + termDef: + term: >- + Low Grade Endometrioid Stromal Sarcoma + source: NCIt + cde_id: C4263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4263" + term_id: C4263 + term_version: 20.05a + +endometrial_stromal_sarcoma_nos: + common: + description: >- + A malignant mesenchymal neoplasm that affects the uterine corpus, and rarely, + the ovaries, cervix, and vagina. In the uterine corpus it is classified as low + grade or high grade endometrial stromal sarcoma. In the remainder of the anatomic + sites it is classified as low grade endometrioid stromal sarcoma. + termDef: + term: >- + Endometrioid Stromal Sarcoma + source: NCIt + cde_id: C8973 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8973" + term_id: C8973 + term_version: 20.05a + +endometrial_stromatosis: + common: + description: >- + An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, + and the ovary. It is characterized by the presence of oval to spindle-shape + cells that resemble the cells of the endometrial stroma, without evidence of + significant atypia and pleomorphism. Numerous small vessels are also present. + It is usually characterized by indolent growth and late recurrences. + termDef: + term: >- + Low Grade Endometrioid Stromal Sarcoma + source: NCIt + cde_id: C4263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4263" + term_id: C4263 + term_version: 20.05a + +endometrioid_adenocarcinoma_ciliated_cell_variant: + common: + description: >- + An endometrioid adenocarcinoma arising from the endometrium, in which ciliated + cells line the majority of the malignant glands. + termDef: + term: >- + Endometrial Endometrioid Adenocarcinoma, Ciliated Variant + source: NCIt + cde_id: C27848 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27848" + term_id: C27848 + term_version: 20.05a + +endometrioid_adenocarcinoma_nos: + common: + description: >- + An adenocarcinoma characterized by the presence of malignant glandular epithelial + cells resembling endometrial cells. It can arise from the uterine body, ovary, + fallopian tube, cervix, vagina, and uterine ligament. + termDef: + term: >- + Endometrioid Adenocarcinoma + source: NCIt + cde_id: C3769 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3769" + term_id: C3769 + term_version: 20.05a + +endometrioid_adenocarcinoma_secretory_variant: + common: + description: >- + An endometrioid adenocarcinoma arising from the endometrium. Morphologically + it is characterized by the presence of malignant glandular cells containing + glycogen vacuoles which are usually subnuclear and reminiscent of early secretory + endometrium. + termDef: + term: >- + Endometrial Endometrioid Adenocarcinoma, Secretory Variant + source: NCIt + cde_id: C27839 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27839" + term_id: C27839 + term_version: 20.05a + +endometrioid_adenocarcinoma_villoglandular: + common: + description: >- + A primary endometrioid adenocarcinoma of the endometrium characterized by the + presence of numerous finger-like villi lined by neoplastic columnar cells. + termDef: + term: >- + Villoglandular Endometrial Endometrioid Adenocarcinoma + source: NCIt + cde_id: C27846 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27846" + term_id: C27846 + term_version: 20.05a + +endometrioid_adenofibroma_borderline_malignancy: + common: + description: >- + An epithelial neoplasm that arises from the ovary characterized by the presence + of glandular or cystic spaces which contain atypical glandular epithelial cells + resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. + There is no evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid + Tumor + source: NCIt + cde_id: C7983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7983" + term_id: C7983 + term_version: 20.05a + +endometrioid_adenofibroma_nos: + common: + description: >- + A benign neoplasm of the ovary characterized by the presence of glandular structures + with endometrial-type well-differentiated cells in a fibrotic stroma. + termDef: + term: >- + Ovarian Endometrioid Adenofibroma + source: NCIt + cde_id: C27287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27287" + term_id: C27287 + term_version: 20.05a + +endometrioid_adenoma_borderline_malignancy: + common: + description: >- + An epithelial neoplasm that arises from the ovary characterized by the presence + of glandular or cystic spaces which contain atypical glandular epithelial cells + resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. + There is no evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid + Tumor + source: NCIt + cde_id: C7983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7983" + term_id: C7983 + term_version: 20.05a + +endometrioid_carcinoma_nos: + common: + description: >- + An adenocarcinoma characterized by the presence of malignant glandular epithelial + cells resembling endometrial cells. It can arise from the uterine body, ovary, + fallopian tube, cervix, vagina, and uterine ligament. + termDef: + term: >- + Endometrioid Adenocarcinoma + source: NCIt + cde_id: C3769 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3769" + term_id: C3769 + term_version: 20.05a + +endometrioid_carcinoma_with_squamous_differentiation: + common: + description: >- + An endometrioid adenocarcinoma of the endometrium showing squamous differentiation. + termDef: + term: >- + Endometrial Endometrioid Adenocarcinoma, Variant with Squamous Differentiation + source: NCIt + cde_id: C6290 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6290" + term_id: C6290 + term_version: 20.05a + +endometrioid_cystadenocarcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of malignant glandular epithelial + cells resembling endometrial cells. It can arise from the uterine body, ovary, + fallopian tube, cervix, vagina, and uterine ligament. + termDef: + term: >- + Endometrioid Adenocarcinoma + source: NCIt + cde_id: C3769 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3769" + term_id: C3769 + term_version: 20.05a + +endometrioid_cystadenofibroma_borderline_malignancy: + common: + description: >- + An epithelial neoplasm that arises from the ovary characterized by the presence + of glandular or cystic spaces which contain atypical glandular epithelial cells + resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. + There is no evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid + Tumor + source: NCIt + cde_id: C7983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7983" + term_id: C7983 + term_version: 20.05a + +endometrioid_cystadenofibroma_nos: + common: + description: >- + A benign neoplasm of the ovary characterized by the presence of cystic structures + lined by endometrial-type well-differentiated cells in a fibrotic stroma. + termDef: + term: >- + Ovarian Endometrioid Cystadenofibroma + source: NCIt + cde_id: C27288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27288" + term_id: C27288 + term_version: 20.05a + +endometrioid_cystadenoma_borderline_malignancy: + common: + description: >- + An epithelial neoplasm that arises from the ovary characterized by the presence + of glandular or cystic spaces which contain atypical glandular epithelial cells + resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. + There is no evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid + Tumor + source: NCIt + cde_id: C7983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7983" + term_id: C7983 + term_version: 20.05a + +endometrioid_tumor_of_low_malignant_potential: + common: + description: >- + An epithelial neoplasm that arises from the ovary characterized by the presence + of glandular or cystic spaces which contain atypical glandular epithelial cells + resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. + There is no evidence of stromal invasion. + termDef: + term: >- + Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid + Tumor + source: NCIt + cde_id: C7983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7983" + term_id: C7983 + term_version: 20.05a + +endometrium: + common: + description: >- + The mucous membrane comprising the inner layer of the uterine wall; it consists + of a simple columnar epithelium and a lamina propria that contains simple tubular + uterine glands. The structure, thickness, and state of the endometrium undergo + marked change with the menstrual cycle. + termDef: + term: >- + Endometrium + source: NCIt + cde_id: C12313 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12313" + term_id: C12313 + term_version: 20.05a + +endothelin_b_receptor_blocker_enb_003: + common: + description: >- + An antagonist of the immune checkpoint endothelin B receptor (ETBR; EDNRB), + with potential immunomodulating and antineoplastic activities. Upon administration, + the ETBR blocker ENB 003 selectively targets and binds to ETBR expressed on + tumor cells. This prevents ETBR-mediated signaling and may abrogate the immunosuppressive + tumor microenvironment (TME), may enhance a T-cell mediated anti-tumor immune + response and may inhibit proliferation of ETBR-expressing tumor cells. ETBR, + a G-protein coupled receptor, is overexpressed in a variety of tumor cell types + and plays a key role in tumor cell proliferation, invasion, epithelial-mesenchymal + transition (EMT) and angiogenesis. It also plays a role in tumor immunosuppression + and blocks T-cell trafficking. + termDef: + term: >- + Endothelin B Receptor Blocker ENB 003 + source: NCIt + cde_id: C175447 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175447" + term_id: C175447 + term_version: 20.10d + +endotheliomatous_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of tumor cells that form + lobules. The tumor cells are generally uniform. Whorls and psammoma bodies are + usually not present. + termDef: + term: >- + Meningothelial Meningioma + source: NCIt + cde_id: C4329 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4329" + term_id: C4329 + term_version: 20.05a + +endovascular_papillary_angioendothelioma: + common: + description: >- + An intermediate, rarely metastasizing blood vessel neoplasm. It is characterized + by the presence of lymphatic-like vascular channels and papillary endothelial + proliferation. + termDef: + term: >- + Papillary Intralymphatic Angioendothelioma + source: NCIt + cde_id: C7526 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7526" + term_id: C7526 + term_version: 20.05a + +endstage_renal_disease: + common: + description: >- + Long-standing and persistent renal disease with glomerular filtration rate (GFR) + less than 15 ml/min. + termDef: + term: >- + Chronic Kidney Disease, Stage 5 + source: NCIt + cde_id: C9439 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9439" + term_id: C9439 + term_version: 19.12e + +engineered_red_blood_cells_coexpressing_41bbl_and_il15tp_rtx240: + common: + description: >- + A preparation of allogeneic, off-the-shelf (OTS) red blood cells (RBCs) engineered + to express both the co-stimulatory molecule tumor necrosis factor ligand superfamily + (TNFSF) member 9 (TNFSF9; 4-1BBL) and a fusion protein composed of the trans-presented + cytokine interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) (IL-15TP) with potential + modulating and antineoplastic activities. CD34+ hematopoietic precursor cells + (HPC) are collected by apheresis from a healthy O negative donor, purified, + and engineered with a lentiviral vector to express 4-1BBL and IL-15TP. The cells + are then further expanded and differentiated until the nucleus is ejected, resulting + in a mature reticulocyte. Upon administration of the engineered red blood cells + co-expressing 4-1BBL and IL-15TP RTX-240, the RBCs express both 4-1BBL and IL-15TP + on their cell surfaces. 4-1BBL and IL-15TP bind to and subsequently induce the + proliferation and activation of natural killer (NK) cells and T-cells. This + enhances the secretion of cytokine interferon-gamma (IFN-g) and results in the + induction of an anti-tumor immune response. + termDef: + term: >- + Engineered Red Blood Cells Co-expressing 4-1BBL and IL-15TP RTX-240 + source: NCIt + cde_id: C172990 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172990" + term_id: C172990 + term_version: 20.10d + +engineered_toxin_body_targeting_cd38_tak169: + common: + description: >- + An engineered toxin body (ETB) containing a single chain variable fragment (scFv) + from an antibody targeting the cell surface glycoprotein ADP-ribosyl cyclase + 1 (CD38) that is fused to a cytotoxic payload composed of the enzymatically + active, de-immunized, ribosome-inactivating cytotoxic payload Shiga-like toxin-A + subunit (SLTA), with potential antineoplastic activity. Upon administration, + the anti-CD38 scFv moiety of TAK-169 specifically targets and binds to CD38-expressing + tumor cells. Upon internalization, the SLTA moiety is released and acts as an + N-glycosidase, which binds to and removes an adenine nucleobase from the 28S + RNA component of the 60S ribosomal subunit.of ribosomes This prevents ribosome + activity, This inhibits protein synthesis and leads to apoptosis in CD38-expressing + tumor cells. CD38, a type II transmembrane glycoprotein, is present on various + immune cells and hematologic malignancies; its expression has been correlated + with poor prognosis. + termDef: + term: >- + Engineered Toxin Body Targeting CD38 TAK-169 + source: NCIt + cde_id: C173707 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173707" + term_id: C173707 + term_version: 20.10d + +enterochromaffinlike_cell_carcinoid_nos: + common: + description: >- + A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) arising + from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like + type granules in the neoplastic cells. + termDef: + term: >- + Enterochromaffin-Like Cell Neuroendocrine Tumor G1 + source: NCIt + cde_id: C27252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27252" + term_id: C27252 + term_version: 20.05a + +enterochromaffinlike_cell_tumor_malignant: + common: + description: >- + A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) arising + from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like + type granules in the neoplastic cells. + termDef: + term: >- + Enterochromaffin-Like Cell Neuroendocrine Tumor G1 + source: NCIt + cde_id: C27252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27252" + term_id: C27252 + term_version: 20.05a + +enteroglucagonoma_malignant: + common: + description: >- + A glucagon-producing malignant endocrine neoplasm. It displays vascular invasion + and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Enteroglucagonoma + source: NCIt + cde_id: C65191 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65191" + term_id: C65191 + term_version: 20.05a + +enteroglucagonoma_nos: + common: + description: >- + An endocrine neoplasm producing glucagon. + termDef: + term: >- + Enteroglucagonoma + source: NCIt + cde_id: C66925 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66925" + term_id: C66925 + term_version: 20.05a + +enteropathy_associated_tcell_lymphoma: + common: + description: >- + A mature T-cell and NK-cell non-Hodgkin lymphoma of intraepithelial T-lymphocytes. + It usually arises from the small intestine, most commonly the jejunum or ileum. Other + less frequent primary anatomic sites include the duodenum, stomach, colon, or + outside the gastrointestinal tract. It is characterized by the presence of pleomorphic + medium-sized to large T-lymphocytes with vesicular nuclei, prominent nucleoli, + and moderate to abundant pale cytoplasm. It is associated with celiac disease. + termDef: + term: >- + Enteropathy-Associated T-Cell Lymphoma + source: NCIt + cde_id: C4737 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4737" + term_id: C4737 + term_version: 20.05a + +enteropathy_type_intestinal_tcell_lymphoma: + common: + description: >- + A mature T-cell and NK-cell non-Hodgkin lymphoma of intraepithelial T-lymphocytes. + It usually arises from the small intestine, most commonly the jejunum or ileum. Other + less frequent primary anatomic sites include the duodenum, stomach, colon, or + outside the gastrointestinal tract. It is characterized by the presence of pleomorphic + medium-sized to large T-lymphocytes with vesicular nuclei, prominent nucleoli, + and moderate to abundant pale cytoplasm. It is associated with celiac disease. + termDef: + term: >- + Enteropathy-Associated T-Cell Lymphoma + source: NCIt + cde_id: C4737 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4737" + term_id: C4737 + term_version: 20.05a + +enucleation: + common: + description: >- + A surgical procedure by which tissue or an organ (usually containing a tumor) + is removed without rupture from a specific anatomic site. + termDef: + term: >- + Enucleation + source: NCIt + cde_id: C48601 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48601" + term_id: C48601 + term_version: 20.05a + +environmental_tobacco_smoke: + common: + description: >- + Exposure to tobacco smoke products among individuals who do not smoke. This + can result from sharing space with a smoker or from placental transfer from + mother to fetus. + termDef: + term: >- + Passive Smoke Exposure + source: NCIt + cde_id: C17140 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17140" + term_id: C17140 + term_version: 19.12e + +eosinophil: + common: + description: >- + The determination of the number of eosinophils in a blood sample. + termDef: + term: >- + Eosinophil Count + source: NCIt + cde_id: C64550 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64550" + term_id: C64550 + term_version: 20.10d + +eosinophil_adenocarcinoma: + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with acidic dyes. + termDef: + term: >- + Pituitary Gland Acidophil Carcinoma + source: NCIt + cde_id: C4147 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4147" + term_id: C4147 + term_version: 20.05a + +eosinophil_adenoma: + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells stain positive with acidic dyes. + termDef: + term: >- + Pituitary Gland Acidophil Adenoma + source: NCIt + cde_id: C6780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6780" + term_id: C6780 + term_version: 20.05a + +eosinophil_carcinoma: + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with acidic dyes. + termDef: + term: >- + Pituitary Gland Acidophil Carcinoma + source: NCIt + cde_id: C4147 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4147" + term_id: C4147 + term_version: 20.05a + +eosinophilic_granuloma: + common: + description: >- + A clinical variant of Langerhans cell histiocytosis characterized by unifocal + involvement of a bone (most often), skin, or lung. Patients are usually older + children or adults usually presenting with a lytic bone lesion. The etiology + is unknown. Morphologically, eosinophilic granuloma is characterized by the + presence of Langerhans cells in a characteristic milieu which includes histiocytes, + eosinophils, neutrophils, and small, mature lymphocytes. + termDef: + term: >- + Eosinophilic Granuloma + source: NCIt + cde_id: C3016 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3016" + term_id: C3016 + term_version: 20.05a + +eosinophilic_leukemia: + common: + description: >- + A rare myeloproliferative neoplasm characterized by a clonal proliferation of + eosinophilic precursors resulting in persistently increased numbers of eosinophils + in the blood, marrow and peripheral tissues. Since acute eosinophilic leukemia + is at best exceedingly rare, the term eosinophilic leukemia is normally used + as a synonym for chronic eosinophilic leukemia. In cases in which it is impossible + to prove clonality and there is no increase in blast cells, the diagnosis of + "idiopathic hypereosinophilic syndrome" is preferred. (WHO, 2001) + termDef: + term: >- + Chronic Eosinophilic Leukemia, Not Otherwise Specified + source: NCIt + cde_id: C4563 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4563" + term_id: C4563 + term_version: 20.05a + +ep2ep4_antagonist_tpst1495: + common: + description: >- + An orally bioavailable, dual antagonist of the human prostaglandin E2 receptor + subtypes 2 (EP2) and 4 (EP4), with potential immunomodulating and antineoplastic + activities. Upon oral administration, the EP2/EP4 antagonist TPST-1495 selectively + targets and binds to EP2 and EP4, inhibiting the binding of the immunosuppressive + prostaglandin E2 (PGE2) to EP2 and EP4. This prevents the activation of EP2 + and EP4, and inhibits PGE2-EP2/EP4-mediated signaling. This inhibits PGE2-driven + immune suppression by preventing the PGE2-mediated inhibition of anti-tumor + immune effector cells in the tumor microenvironment (TME), such as natural killer + (NK) cells, T-lymphocytes, dendritic cells (DCs) and M1 macrophages, and blocking + the PGE2-mediated increase in suppressive immune cells, such as myeloid derived + suppressor cells (MDSCs), M2 macrophages, and regulatory T cells (Tregs). This + inhibits the proliferation of tumor cells in which the PGE2-EP2/4 signaling + pathway is over-activated. EP2 and EP4, G protein-coupled receptors (GPCRs) + that are overexpressed in certain types of cancers, promote tumor cell proliferation, + invasion, survival, and metastasis. + termDef: + term: >- + EP2/EP4 Antagonist TPST-1495 + source: NCIt + cde_id: C174460 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174460" + term_id: C174460 + term_version: 20.10d + +ep300: + common: + description: >- + This gene plays a role in DNA repair and regulation of transcription. + termDef: + term: >- + EP300 Gene + source: NCIt + cde_id: C26569 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26569" + term_id: C26569 + term_version: 20.10d + +ep4_antagonist_inv1120: + common: + description: >- + A small molecule and antagonist of the prostaglandin E2 receptor subtype 4 (PTGER4; + EP4), with potential immunomodulating and antineoplastic activities. Upon administration, + the EP4 antagonist INV-1120 selectively targets and binds to EP4, inhibiting + the binding of the immunosuppressive prostaglandin E2 (PGE2) to EP4. This prevents + the activation of EP4 and inhibits PGE2-EP4-mediated signaling, thereby inhibiting + proliferation of tumor cells in which the PGE2-EP4 signaling pathway is over-activated. + In addition, EP4 inhibition prevents the activity of tumor-associated myeloid + cells (TAMCs) in the tumor microenvironment (TME) by inhibiting interleukin-23 + (IL-23) production and the IL-23-mediated expansion of Th17 cells. EP4, a prostanoid + receptor, is a G protein-coupled receptor that is expressed in certain types + of cancers; it promotes tumor cell proliferation and invasion. + termDef: + term: >- + EP4 Antagonist INV-1120 + source: NCIt + cde_id: C173520 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173520" + term_id: C173520 + term_version: 20.10d + +epas1: + common: + description: >- + This gene plays a role in the cellular response to hypoxia. + termDef: + term: >- + EPAS1 Gene + source: NCIt + cde_id: C104303 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104303" + term_id: C104303 + term_version: 20.10d + +epcoritamab: + common: + description: >- + A bispecific monoclonal antibody, with potential immunomodulating and antineoplastic + activities. Epcoritamab contains two antigen-recognition sites: one for human + CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen + (TAA) that is exclusively expressed on B-cells during most stages of B-cell + development and is often overexpressed in B-cell malignancies. Upon administration, + epcoritamab binds to both T-cells and CD20-expressing B-lineage tumor cells. + The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) + response against the CD20-expressing tumor B-cells. + termDef: + term: >- + Epcoritamab + source: NCIt + cde_id: C163022 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C163022" + term_id: C163022 + term_version: 20.10d + +ependymoblastoma: + common: + description: >- + An aggressive malignant embryonal neoplasm arising from the central nervous + system. It is characterized by the presence of multilayered rosettes formation + and the presence of amplification of the C19MC region on chromosome 19 (19q13.42). + termDef: + term: >- + Embryonal Tumor with Multilayered Rosettes, C19MC-Altered + source: NCIt + cde_id: C4915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4915" + term_id: C4915 + term_version: 20.05a + +ependymoma_anaplastic: + common: + description: >- + A WHO grade III malignant glioma of ependymal origin with accelerated growth + and an unfavorable clinical outcome, particularly in children. It is characterized + by high mitotic activity, often accompanied by microvascular proliferation and + pseudo-palisading necrosis. (Adapted from WHO) + termDef: + term: >- + Anaplastic Ependymoma + source: NCIt + cde_id: C4049 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4049" + term_id: C4049 + term_version: 20.05a + +ependymoma_nos: + common: + description: >- + A WHO grade II, slow growing tumor of children and young adults, usually located + intraventricularly. It is the most common ependymal neoplasm. It often causes + clinical symptoms by blocking cerebrospinal fluid pathways. Key histological + features include perivascular pseudorosettes and ependymal rosettes. (WHO) + termDef: + term: >- + Ependymoma + source: NCIt + cde_id: C3017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3017" + term_id: C3017 + term_version: 20.05a + +ependymoma_rela_fusionpositive: + common: + description: >- + An ependymoma characterized by gene fusions involving RELA, a transcription + factor involved in NK-kB pathway activity. It accounts for the majority of supratentorial + ependymomas in children. It has an unfavorable outcome when compared to other + ependymoma subtypes. + termDef: + term: >- + Ependymoma, RELA Fusion-Positive + source: NCIt + cde_id: C129351 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129351" + term_id: C129351 + term_version: 20.05a + +epha2targeting_bicycle_toxin_conjugate_bt5528: + common: + description: >- + A bicyclic peptide targeting Ephrin receptor A2 (EphA2) and conjugated, through + an inert sarcosine spacer chain and a valine-citrulline cleavable linker, to + the cytotoxic agent monomethyl auristatin E (MMAE), an auristatin derivative + and a potent inhibitor of microtubule polymerization, with potential antineoplastic + activity. Upon administration of the EphA2-targeting bicycle toxin conjugate + BT5528, this agent targets and binds to EphA2-expressing tumor cells. After + internalization and enzymatic cleavage of the immunoconjugate within the tumor + cell cytosol, free MMAE binds to tubulin and inhibits its polymerization, which + may result in G2/M phase arrest and tumor cell apoptosis. The cell-surface receptor + EphA2, a member of the ephrin family of receptor tyrosine kinases (RTKs) involved + in mammalian development, is overexpressed by a variety of different cancer + cell types. EphA2 expression is associated with poor prognosis. + termDef: + term: >- + EphA2-targeting Bicycle Toxin Conjugate BT5528 + source: NCIt + cde_id: C171425 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171425" + term_id: C171425 + term_version: 20.10d + +epha3: + common: + description: >- + This gene is involved in receptor tyrosine kinase signal transduction and plays + a role in lymphoid function and differentiation. + termDef: + term: >- + EPHA3 Gene + source: NCIt + cde_id: C18384 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18384" + term_id: C18384 + term_version: 20.10d + +epha7: + common: + description: >- + This gene plays a role in mediation of developmental processes. + termDef: + term: >- + EPHA7 Gene + source: NCIt + cde_id: C111841 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111841" + term_id: C111841 + term_version: 20.10d + +epidermoid_carcinoma_in_situ_nos: + common: + description: >- + A malignant epithelial neoplasm confined to the squamous epithelium, without + invasion of the underlying tissues. + termDef: + term: >- + Stage 0 Squamous Cell Carcinoma + source: NCIt + cde_id: C27093 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27093" + term_id: C27093 + term_version: 20.05a + +epidermoid_carcinoma_in_situ_with_questionable_stromal_invasion: + common: + description: >- + A malignant epithelial neoplasm involving all the layers of the squamous epithelium, + but it is not certain if it is confined to the squamous epithelium or it has + invaded the basement membrane and the underlying stroma. + termDef: + term: >- + Squamous Cell Carcinoma In Situ with Questionable Stromal Invasion + source: NCIt + cde_id: C65176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65176" + term_id: C65176 + term_version: 20.05a + +epidermoid_carcinoma_keratinizing: + common: + description: >- + Squamous cell carcinomas with morphologically prominent production of keratin. + termDef: + term: >- + Keratinizing Squamous Cell Carcinoma + source: NCIt + cde_id: C4105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4105" + term_id: C4105 + term_version: 20.05a + +epidermoid_carcinoma_large_cell_nonkeratinizing: + common: + description: >- + A squamous cell carcinoma composed of large atypical cells, without morphologic + evidence of keratin production. + termDef: + term: >- + Non-Keratinizing Large Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C65173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65173" + term_id: C65173 + term_version: 20.05a + +epidermoid_carcinoma_nos: + common: + description: >- + A carcinoma arising from squamous epithelial cells. Morphologically, it is + characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous + cell carcinomas are graded by the degree of cellular differentiation as well, + moderately, or poorly differentiated. Well differentiated carcinomas are usually + associated with keratin production and the presence of intercellular bridges + between adjacent cells. Representative examples are lung squamous cell carcinoma, + skin squamous cell carcinoma, and cervical squamous cell carcinoma. + termDef: + term: >- + Squamous Cell Carcinoma + source: NCIt + cde_id: C2929 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2929" + term_id: C2929 + term_version: 20.05a + +epidermoid_carcinoma_small_cell_nonkeratinizing: + common: + description: >- + A squamous cell carcinoma composed of small atypical cells, without morphologic + evidence of keratin production. + termDef: + term: >- + Non-Keratinizing Small Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C65175 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65175" + term_id: C65175 + term_version: 20.05a + +epidermoid_carcinoma_spindle_cell: + common: + description: >- + A poorly differentiated squamous cell carcinoma characterized by the presence + of malignant cells with spindle cell features. + termDef: + term: >- + Spindle Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C27084 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27084" + term_id: C27084 + term_version: 20.05a + +epididymis: + common: + description: >- + A crescent-like structure located in the upper and posterior surfaces of the + testis. It consists of the efferent ductules and the duct of the epididymis. + It facilitates the maturation of sperm that is produced in the testis. + termDef: + term: >- + Epididymis + source: NCIt + cde_id: C12328 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12328" + term_id: C12328 + term_version: 20.05a + +epithelial_ependymoma: + common: + description: >- + A WHO grade II, slow growing tumor of children and young adults, usually located + intraventricularly. It is the most common ependymal neoplasm. It often causes + clinical symptoms by blocking cerebrospinal fluid pathways. Key histological + features include perivascular pseudorosettes and ependymal rosettes. (WHO) + termDef: + term: >- + Ependymoma + source: NCIt + cde_id: C3017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3017" + term_id: C3017 + term_version: 20.05a + +epithelial_tumor_benign: + common: + description: >- + A neoplasm arising from the epithelial cells. It is characterized by the absence + of morphologic features associated with malignancy (severe cytologic atypia, + tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain + confined to the original site of growth and only rarely metastasize to other + anatomic sites. + termDef: + term: >- + Benign Epithelial Neoplasm + source: NCIt + cde_id: C4092 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4092" + term_id: C4092 + term_version: 20.05a + +epithelial_tumor_malignant: + common: + description: >- + A malignant tumor arising from epithelial cells. Carcinomas that arise from + glandular epithelium are called adenocarcinomas, those that arise from squamous + epithelium are called squamous cell carcinomas, and those that arise from transitional + epithelium are called transitional cell carcinomas. Morphologically, the malignant + epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. + Carcinomas are graded by the degree of cellular differentiation as well, moderately, + or poorly differentiated. Carcinomas invade the surrounding tissues and tend + to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast + carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen + carcinomas. + termDef: + term: >- + Carcinoma + source: NCIt + cde_id: C2916 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2916" + term_id: C2916 + term_version: 20.05a + +epithelialmyoepithelial_carcinoma: + common: + description: >- + A malignant neoplasm which occurs mostly in the major salivary glands (most + frequently in the parotid gland), but also in the minor salivary glands of the + oral mucosa and the tracheobronchial tree. It is characterized by the presence + of ductal structures which are lined by an inner layer of cuboidal epithelial-type + cells and an outer layer of myoepithelial cells with clear or eosinophilic cytoplasm. + termDef: + term: >- + Epithelial-Myoepithelial Carcinoma + source: NCIt + cde_id: C4199 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4199" + term_id: C4199 + term_version: 20.05a + +epithelioid_and_spindle_cell_nevus: + common: + description: >- + A benign, acquired or congenital, usually single skin lesion. It can occur on + any area of the body, but most commonly occurs on the face of children and the + thighs of young females. It is characterized by a proliferation of large spindle, + oval, or large epithelioid melanocytes in the dermal-epidermal junction. The + melanocytic proliferation subsequently extends into the dermis. + termDef: + term: >- + Spitz Nevus + source: NCIt + cde_id: C27007 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27007" + term_id: C27007 + term_version: 20.05a + +epithelioid_cell_melanoma: + common: + description: >- + A melanoma characterized by the presence of malignant large epithelioid melanocytes. + termDef: + term: >- + Epithelioid Cell Melanoma + source: NCIt + cde_id: C4236 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4236" + term_id: C4236 + term_version: 20.05a + +epithelioid_cell_nevus: + common: + description: >- + A nevus characterized by the presence of large epithelioid melanocytes. + termDef: + term: >- + Epithelioid Cell Nevus + source: NCIt + cde_id: C66757 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66757" + term_id: C66757 + term_version: 20.05a + +epithelioid_cell_sarcoma: + common: + description: >- + An aggressive malignant neoplasm of uncertain differentiation, characterized + by the presence of epithelioid cells forming nodular patterns. The nodules + often undergo central necrosis, resulting in a pseudogranulomatous growth pattern. It + usually occurs in young adults. The most common sites of involvement are the + extremities (distal-type epithelioid sarcoma), and less frequently the pelvis, + perineum, and genital organs (proximal-type epithelioid sarcoma). + termDef: + term: >- + Epithelioid Sarcoma + source: NCIt + cde_id: C3714 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3714" + term_id: C3714 + term_version: 20.05a + +epithelioid_glioblastoma: + common: + description: >- + An IDH-wildtype glioblastoma characterized by the presence of large epithelioid + cells with abundant eosinophilic cytoplasm, vesicular chromatin, and prominent + nucleoli. + termDef: + term: >- + Epithelioid Glioblastoma + source: NCIt + cde_id: C129293 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129293" + term_id: C129293 + term_version: 20.05a + +epithelioid_hemangioendothelioma_nos: + common: + description: >- + A low-grade malignant blood vessel neoplasm. It is characterized by the presence + of epithelioid endothelial cells. The neoplastic cells are arranged in cords + and nests, which are embedded in a myxoid to hyalinized stroma. + termDef: + term: >- + Epithelioid Hemangioendothelioma + source: NCIt + cde_id: C3800 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3800" + term_id: C3800 + term_version: 20.05a + +epithelioid_hemangioma: + common: + description: >- + A hemangioma characterized by the presence of epithelioid endothelial cells. + termDef: + term: >- + Epithelioid Hemangioma + source: NCIt + cde_id: C4298 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4298" + term_id: C4298 + term_version: 20.05a + +epithelioid_leiomyoma: + common: + description: >- + A benign or malignant gastrointestinal stromal tumor with epithelioid morphology. + termDef: + term: >- + Epithelioid Cell Type Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C3486 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3486" + term_id: C3486 + term_version: 20.05a + +epithelioid_leiomyosarcoma: + common: + description: >- + A morphologic variant of leiomyosarcoma characterized by the presence of epithelioid + round cells with eosinophilic to clear cytoplasm. + termDef: + term: >- + Epithelioid Leiomyosarcoma + source: NCIt + cde_id: C3700 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3700" + term_id: C3700 + term_version: 20.05a + +epithelioid_malignant_peripheral_nerve_sheath_tumor: + common: + description: >- + A rare variant of malignant peripheral nerve sheath tumor composed predominantly + or exclusively of epithelioid cells. + termDef: + term: >- + Epithelioid Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C6561 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6561" + term_id: C6561 + term_version: 20.05a + +epithelioid_mesothelioma_benign: + common: + description: >- + A benign neoplasm arising from mesothelial cells. It is characterized by the + formation of glandular and tubular patterns. It can occur in several anatomic + sites including the pleura, peritoneum, and epididymis. + termDef: + term: >- + Adenomatoid Tumor + source: NCIt + cde_id: C3762 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3762" + term_id: C3762 + term_version: 20.05a + +epithelioid_mesothelioma_malignant: + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of cells with epithelioid morphology. The epithelioid cells usually + have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, + or sheet-like patterns. + termDef: + term: >- + Epithelioid Mesothelioma + source: NCIt + cde_id: C7985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7985" + term_id: C7985 + term_version: 20.05a + +epithelioid_mesothelioma_nos: + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of cells with epithelioid morphology. The epithelioid cells usually + have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, + or sheet-like patterns. + termDef: + term: >- + Epithelioid Mesothelioma + source: NCIt + cde_id: C7985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7985" + term_id: C7985 + term_version: 20.05a + +epithelioid_mpnst: + common: + description: >- + A rare variant of malignant peripheral nerve sheath tumor composed predominantly + or exclusively of epithelioid cells. + termDef: + term: >- + Epithelioid Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C6561 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6561" + term_id: C6561 + term_version: 20.05a + +epithelioid_sarcoma: + common: + description: >- + An aggressive malignant neoplasm of uncertain differentiation, characterized + by the presence of epithelioid cells forming nodular patterns. The nodules + often undergo central necrosis, resulting in a pseudogranulomatous growth pattern. It + usually occurs in young adults. The most common sites of involvement are the + extremities (distal-type epithelioid sarcoma), and less frequently the pelvis, + perineum, and genital organs (proximal-type epithelioid sarcoma). + termDef: + term: >- + Epithelioid Sarcoma + source: NCIt + cde_id: C3714 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3714" + term_id: C3714 + term_version: 20.05a + +epithelioma_adenoides_cysticum: + common: + description: >- + A benign hair follicle neoplasm with trichoblastic differentiation. It usually + presents as a solitary papular lesion It most often presents on the head and + neck area, but it may develop in any anatomic site containing hair follicles. + Because of its benign nature, treatment usually is not required, provided that + the diagnosis has been established with certainty. + termDef: + term: >- + Trichoblastoma + source: NCIt + cde_id: C27132 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27132" + term_id: C27132 + term_version: 20.05a + +epithelioma_benign: + common: + description: >- + A neoplasm arising from the epithelial cells. It is characterized by the absence + of morphologic features associated with malignancy (severe cytologic atypia, + tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain + confined to the original site of growth and only rarely metastasize to other + anatomic sites. + termDef: + term: >- + Benign Epithelial Neoplasm + source: NCIt + cde_id: C4092 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4092" + term_id: C4092 + term_version: 20.05a + +epithelioma_nos: + common: + description: >- + A benign or malignant neoplasm that arises from and is composed of epithelial + cells. This category include adenomas, papillomas, and carcinomas. + termDef: + term: >- + Epithelial Neoplasm + source: NCIt + cde_id: C3709 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3709" + term_id: C3709 + term_version: 20.05a + +epitrochlear: + common: + description: >- + A lymph node located above and adjacent to the elbow. + termDef: + term: >- + Epitrochlear Lymph Node + source: NCIt + cde_id: C98182 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98182" + term_id: C98182 + term_version: 20.10d + +eps15: + common: + description: >- + This gene plays a role in signal transduction and cell proliferation. + termDef: + term: >- + EPS15 Gene + source: NCIt + cde_id: C24369 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24369" + term_id: C24369 + term_version: 20.10d + +epsteinbarr_virus: + common: + description: >- + Any microbiologic test or molecular assay used to detect the presence of Epstein-Barr + virus in a sample. + termDef: + term: >- + Epstein-Barr Virus Test + source: NCIt + cde_id: C171143 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171143" + term_id: C171143 + term_version: 20.10d + +equatorial_guinea: + common: + description: >- + A country in western Africa, bordering the Gulf of Guinea, between Cameroon + and Gabon; composed of a mainland portion and five inhabited islands. + termDef: + term: >- + Equatorial Guinea + source: NCIt + cde_id: C16557 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16557" + term_id: C16557 + term_version: 19.12e + +equivocal: + common: + description: >- + Open to question. + termDef: + term: >- + Equivocal + source: NCIt + cde_id: C86071 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C86071" + term_id: C86071 + term_version: 20.05a + +erbb2: + common: + description: >- + This gene plays a role in cellular proliferation and is involved in the oncogenic + process through amplification and/or overexpression in several cancers. + termDef: + term: >- + ERBB2 Gene + source: NCIt + cde_id: C17756 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17756" + term_id: C17756 + term_version: 20.10d + +erbb3: + common: + description: >- + This gene is involved in signal transduction pathways that result in cellular + proliferation or differentiation. The gene has also been associated with numerous + cancers. + termDef: + term: >- + ERBB3 Gene + source: NCIt + cde_id: C18386 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18386" + term_id: C18386 + term_version: 20.10d + +erbb4: + common: + description: >- + This gene is involved in neuronal development and plays a role in receptor tyrosine + kinase signal transduction that regulates cellular proliferation and differentiation. + termDef: + term: >- + ERBB4 Gene + source: NCIt + cde_id: C18388 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18388" + term_id: C18388 + term_version: 20.10d + +erc1: + common: + description: >- + This gene plays a role in signaling. + termDef: + term: >- + ERC1 Gene + source: NCIt + cde_id: C97499 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97499" + term_id: C97499 + term_version: 20.10d + +ercc2: + common: + description: >- + This gene is involved in nucleotide excision repair and corrects sensitivity + to UV radiation and defective nucleotide excision repair in xeroderma pigmentosum + cells of complementation group D. + termDef: + term: >- + ERCC2 Gene + source: NCIt + cde_id: C20555 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20555" + term_id: C20555 + term_version: 20.10d + +ercc3: + common: + description: >- + This gene is involved in DNA excision repair and transcription. + termDef: + term: >- + ERCC3 Gene + source: NCIt + cde_id: C20556 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20556" + term_id: C20556 + term_version: 20.10d + +ercc4: + common: + description: >- + This gene is involved in nucleotide excision repair and is involved in the correction + of defective nucleotide excision repair in xeroderma pigmentosum cells of complementation + group F. + termDef: + term: >- + ERCC4 Gene + source: NCIt + cde_id: C20558 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20558" + term_id: C20558 + term_version: 20.10d + +ercc5: + common: + description: >- + This gene plays a role in the nucleotide base excision repair of UV-induced + DNA damage and mutations of the gene cause Cockayne syndrome. + termDef: + term: >- + ERCC5 Gene + source: NCIt + cde_id: C20557 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20557" + term_id: C20557 + term_version: 20.10d + +erg: + common: + description: >- + This gene plays a regulatory role in transcription, cellular maintenance and + hematopoiesis. + termDef: + term: >- + ERG Gene + source: NCIt + cde_id: C18139 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18139" + term_id: C18139 + term_version: 20.10d + +eritrea: + common: + description: >- + A country in eastern Africa, bordering the Red Sea, between Sudan and Ethiopia. + termDef: + term: >- + Eritrea + source: NCIt + cde_id: C16558 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16558" + term_id: C16558 + term_version: 19.12e + +erk12_inhibitor_hh2710: + common: + description: >- + An orally bioavailable inhibitor of the extracellular signal-regulated kinases + 1 (ERK1) and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, + ERK1/2 inhibitor HH2710 specifically targets, binds to and inhibits the activity + of the serine/threonine-protein kinases ERK1 and ERK2, thereby preventing the + phosphorylation of ERK1/2 substrates and the activation of mitogen-activated + protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results + in the inhibition of ERK-dependent proliferation and survival of tumor cells. + The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK pathway, is hyperactivated + in a variety of tumor cell types due to mutations in upstream targets. It plays + a key role in the proliferation, differentiation and survival of tumor cells. + termDef: + term: >- + ERK1/2 Inhibitor HH2710 + source: NCIt + cde_id: C172805 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172805" + term_id: C172805 + term_version: 20.10d + +erk12_inhibitor_jsi1187: + common: + description: >- + An orally bioavailable inhibitor of the extracellular signal-regulated kinases + 1 (ERK1) and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, + ERK1/2 inhibitor JSI-1187 specifically targets, binds to and inhibits the activity + of the serine/threonine-protein kinases ERK1 and ERK2, thereby preventing the + phosphorylation of ERK1/2 substrates and the activation of mitogen-activated + protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results + in the inhibition of ERK-dependent proliferation and survival of tumor cells. + The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK pathway, is hyperactivated + in a variety of tumor cell types due to mutations in upstream targets. It plays + a key role in the proliferation, differentiation and survival of tumor cells. + termDef: + term: >- + ERK1/2 Inhibitor JSI-1187 + source: NCIt + cde_id: C174203 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174203" + term_id: C174203 + term_version: 20.10d + +erythremic_myelosis_nos: + common: + description: >- + Acute erythroid leukemia characterised by the presence of immature erythroid + cells in the bone marrow (at least 80% of the cellular component), without evidence + of a significant myeloblastic cell population present. + termDef: + term: >- + Pure Erythroid Leukemia + source: NCIt + cde_id: C7467 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7467" + term_id: C7467 + term_version: 20.05a + +erythroleukemia: + common: + description: >- + Acute erythroid leukemia characterised by the presence of at least 50% erythroid + precursors and at least 20% myeloblasts in the bone marrow. + termDef: + term: >- + Erythroleukemia + source: NCIt + cde_id: C7152 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7152" + term_id: C7152 + term_version: 20.05a + +esophageal_cancer: + common: + description: >- + A malignant epithelial tumor arising from the esophageal mucosa. Two major histologic + types of esophageal carcinoma have been described: squamous cell carcinoma and + adenocarcinoma. This type of cancer is associated with excessive ethanol and + cigarette usage. + termDef: + term: >- + Esophageal Carcinoma + source: NCIt + cde_id: C3513 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3513" + term_id: C3513 + term_version: 19.12e + +esophageal_columnar_dysplasia: + common: + description: >- + A morphologic finding the replacement of the normal lower esophagus squamous + epithelium with columnar epithelium. + termDef: + term: >- + Esophageal Columnar Dysplasia + source: NCIt + cde_id: C174120 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174120" + term_id: C174120 + term_version: 20.10d + +esophageal_glandular_dysplasia_intraepithelial_neoplasia_high_grade: + common: + description: >- + A lesion in which the architectural and cytologic abnormalities involve both + the lower and the upper half of the esophageal glandular epithelium. + termDef: + term: >- + High Grade Esophageal Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: C27429 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27429" + term_id: C27429 + term_version: 20.05a + +esophageal_glandular_dysplasia_intraepithelial_neoplasia_low_grade: + common: + description: >- + A lesion in which the architectural and cytologic abnormalities are confined + to the lower half of the esophageal glandular epithelium. + termDef: + term: >- + Low Grade Esophageal Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: C27428 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27428" + term_id: C27428 + term_version: 20.05a + +esophageal_intraepithelial_neoplasia_high_grade: + common: + description: >- + A lesion in which the architectural and cytologic abnormalities involve both + the lower and the upper half of the esophageal mucosa. It includes lesions + termed moderate dysplasia, and carcinoma in situ (severe dysplasia). (WHO, + 2000) + termDef: + term: >- + Esophageal High Grade Intraepithelial Neoplasia + source: NCIt + cde_id: C27425 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27425" + term_id: C27425 + term_version: 20.05a + +esophageal_squamous_intraepithelial_neoplasia_dysplasia_high_grade: + common: + description: >- + A lesion in which the architectural and cytologic abnormalities involve both + the lower and the upper half of the esophageal squamous epithelium. + termDef: + term: >- + High Grade Esophageal Squamous Intraepithelial Neoplasia + source: NCIt + cde_id: C27426 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27426" + term_id: C27426 + term_version: 20.05a + +esophageal_squamous_intraepithelial_neoplasia_dysplasia_low_grade: + common: + description: >- + A lesion in which the architectural and cytologic abnormalities are confined + to the lower half of the esophageal squamous epithelium. + termDef: + term: >- + Low Grade Esophageal Squamous Intraepithelial Neoplasia + source: NCIt + cde_id: C27427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27427" + term_id: C27427 + term_version: 20.05a + +esophagus_nos: + common: + description: >- + The portion of the digestive canal between the pharynx and stomach. It is about + 25 cm long and consists of three parts: the cervical part, from the cricoid + cartilage to the thoracic inlet; thoracic part, from thoracic inlet to the diaphragm; + and abdominal part, below the diaphragm to the cardiac opening of the stomach. + termDef: + term: >- + Esophagus + source: NCIt + cde_id: C12389 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12389" + term_id: C12389 + term_version: 20.05a + +esr1: + common: + description: >- + This gene is involved in ligand-activated transcriptional activity. + termDef: + term: >- + ESR1 Gene + source: NCIt + cde_id: C38349 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38349" + term_id: C38349 + term_version: 20.10d + +essential_hemorrhagic_thrombocythaemia: + common: + description: >- + A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic + lineage. It is characterized by sustained thrombocytosis in the blood, increased + numbers of large, mature megakaryocytes in the bone marrow, and episodes of + thrombosis and/or hemorrhage. (WHO, 2008) + termDef: + term: >- + Essential Thrombocythemia + source: NCIt + cde_id: C3407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3407" + term_id: C3407 + term_version: 20.05a + +essential_thrombocythemia: + common: + description: >- + A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic + lineage. It is characterized by sustained thrombocytosis in the blood, increased + numbers of large, mature megakaryocytes in the bone marrow, and episodes of + thrombosis and/or hemorrhage. (WHO, 2008) + termDef: + term: >- + Essential Thrombocythemia + source: NCIt + cde_id: C3407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3407" + term_id: C3407 + term_version: 20.05a + +esthesioneuroblastoma: + common: + description: >- + A rare neuroectodermal tumor originating from olfactory receptor cells in the + nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic + differentiation with occasional formation of rosettes. If the tumor is not resected + at an early stage, the prognosis is usually poor. + termDef: + term: >- + Olfactory Neuroblastoma + source: NCIt + cde_id: C3789 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3789" + term_id: C3789 + term_version: 20.05a + +esthesioneuroepithelioma: + common: + description: >- + A rare neuroectodermal tumor originating from olfactory receptor cells in the + nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic + differentiation with occasional formation of rosettes. If the tumor is not resected + at an early stage, the prognosis is usually poor. + termDef: + term: >- + Olfactory Neuroblastoma + source: NCIt + cde_id: C3789 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3789" + term_id: C3789 + term_version: 20.05a + +estonia: + common: + description: >- + A country in eastern Europe, bordering the Baltic Sea and Gulf of Finland, between + Latvia and Finland. + termDef: + term: >- + Estonia + source: NCIt + cde_id: C16562 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16562" + term_id: C16562 + term_version: 19.12e + +eswatini: + common: + description: >- + A country in southern Africa, between Mozambique and South Africa. + termDef: + term: >- + Eswatini + source: NCIt + cde_id: C17179 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17179" + term_id: C17179 + term_version: 19.12e + +ethiopia: + common: + description: >- + A country in eastern Africa, between Somalia and Sudan. + termDef: + term: >- + Ethiopia + source: NCIt + cde_id: C16563 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16563" + term_id: C16563 + term_version: 19.12e + +ethmoid_sinus: + common: + description: >- + A sinus of the meatuses of the nasal cavity. + termDef: + term: >- + Ethmoid Sinus + source: NCIt + cde_id: C12276 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12276" + term_id: C12276 + term_version: 20.05a + +etigilimab: + common: + description: >- + A monoclonal antibody targeting the human co-inhibitory molecule and immune + checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor + tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential immune + checkpoint inhibitory activity. Upon administration, etigilimab binds to TIGIT + expressed on various immune cells, including T-cells, and prevents the interaction + of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2; PVRL2) + and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5). This enhances + the interaction of CD112 and CD155 with the costimulatory receptor CD226 (DNAX + Accessory molecule-1; DNAM-1), which is expressed on immune cells, such as natural + killer (NK) cells and CD8-positive T-cells, and leads to CD226 dimerization + and CD226-mediated signaling. This activates the immune system to exert a T-cell-mediated + immune response against cancer cells. TIGIT, a member of the Ig super family + and an immune inhibitory receptor, plays a key role in the suppression of T-cell + proliferation and activation; it is involved in tumor cell immune evasion and + the inhibition of antiviral immune responses. + termDef: + term: >- + Etigilimab + source: NCIt + cde_id: C142821 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142821" + term_id: C142821 + term_version: 20.10d + +etnk1: + common: + description: >- + This gene plays a role in phospholipid biosynthesis. + termDef: + term: >- + ETNK1 Gene + source: NCIt + cde_id: C122823 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122823" + term_id: C122823 + term_version: 20.10d + +etv1: + common: + description: >- + This gene is involved in transcriptional activation and spinal cord development. + termDef: + term: >- + ETV1 Gene + source: NCIt + cde_id: C24377 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24377" + term_id: C24377 + term_version: 20.10d + +etv4: + common: + description: >- + This gene plays a regulatory role in transcription and in matrix metalloproteinase + activity. + termDef: + term: >- + ETV4 Gene + source: NCIt + cde_id: C24378 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24378" + term_id: C24378 + term_version: 20.10d + +etv5: + common: + description: >- + This gene plays a role in the regulation of gene transcription. + termDef: + term: >- + ETV5 Gene + source: NCIt + cde_id: C97479 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97479" + term_id: C97479 + term_version: 20.10d + +etv6: + common: + description: >- + This gene plays a regulatory role in transcription and in matrix metalloproteinase + activity. + termDef: + term: >- + ETV6 Gene + source: NCIt + cde_id: C18312 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18312" + term_id: C18312 + term_version: 20.10d + +every_day: + common: + description: >- + Occurring or done each day. + termDef: + term: >- + Daily + source: NCIt + cde_id: C25473 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25473" + term_id: C25473 + term_version: 19.12e + +ewing_sarcoma: + common: + description: >- + A small round cell tumor that lacks morphologic, immunohistochemical, and electron + microscopic evidence of neuroectodermal differentiation. It represents one of + the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal + tumor. It affects mostly males under age 20, and it can occur in soft tissue + or bone. Pain and the presence of a mass are the most common clinical symptoms. + termDef: + term: >- + Ewing Sarcoma + source: NCIt + cde_id: C4817 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4817" + term_id: C4817 + term_version: 20.05a + +ewing_tumor: + common: + description: >- + A small round cell tumor that lacks morphologic, immunohistochemical, and electron + microscopic evidence of neuroectodermal differentiation. It represents one of + the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal + tumor. It affects mostly males under age 20, and it can occur in soft tissue + or bone. Pain and the presence of a mass are the most common clinical symptoms. + termDef: + term: >- + Ewing Sarcoma + source: NCIt + cde_id: C4817 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4817" + term_id: C4817 + term_version: 20.05a + +ewsr1: + common: + description: >- + This gene may play a role in post-transcriptional regulation; however the function + remains to be elucidated. Mutations in the gene result in Ewing sarcoma and + other tumors. + termDef: + term: >- + EWSR1 Gene + source: NCIt + cde_id: C18322 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18322" + term_id: C18322 + term_version: 20.10d + +excisional_biopsy: + common: + description: >- + A surgical procedure in which an entire lesion is removed for microscopic examination. + termDef: + term: >- + Excisional Biopsy + source: NCIt + cde_id: C15385 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15385" + term_id: C15385 + term_version: 20.05a + +exicorilant: + common: + description: >- + An orally available, selective glucocorticoid receptor (GR) antagonist, with + potential antineoplastic activity. Upon oral administration, exicorilant competitively + and selectively binds to GRs, inhibiting the activation of GR-mediated proliferative + and anti-apoptotic gene expression pathways. The GR, a member of the nuclear + receptor superfamily of ligand-dependent transcription factors, is overexpressed + in certain tumor types and may be associated with tumor cell proliferation and + treatment resistance. Inhibition of GR activity may potentially slow tumor cell + growth and disease progression in certain cancers. + termDef: + term: >- + Exicorilant + source: NCIt + cde_id: C153309 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C153309" + term_id: C153309 + term_version: 20.10d + +exocervix: + common: + description: >- + The portion of the cervix that extends into the vaginal vault, and is lined + with stratified squamous epithelium. + termDef: + term: >- + Ectocervix + source: NCIt + cde_id: C12310 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12310" + term_id: C12310 + term_version: 20.05a + +ext1: + common: + description: >- + This gene plays a role in heparin/heparin sulfate biosynthesis, axon guidance + and biogenesis/cell organization. + termDef: + term: >- + EXT1 Gene + source: NCIt + cde_id: C18251 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18251" + term_id: C18251 + term_version: 20.10d + +ext2: + common: + description: >- + This gene is involved in the heparin/heparin sulfate biosynthesis, cell organization/biogenesis + and development of the cytoskeleton in chondrocytes. + termDef: + term: >- + EXT2 Gene + source: NCIt + cde_id: C18252 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18252" + term_id: C18252 + term_version: 20.10d + +extended_release_metformin_hydrochloride: + common: + description: >- + An extended-release (ER) tablet composed of the hydrochloride salt form of the + biguanide metformin, with antihyperglycemic and potential prostate-cancer protective + and antineoplastic activities. Upon oral administration, metformin targets and + inhibits complex I (NADPH:ubiquinone oxidoreductase) of the mitochondrial respiratory + chain and increases the cellular adenosine monophosphate (AMP) to adenosine + triphosphate (ATP) ratio leading to activation of AMP-activated protein kinase + (AMPK). This modulates AMPK-mediated transcription of target genes, which prevents + hepatic gluconeogenesis, decreases intestinal absorption of glucose, enhances + insulin sensitivity and fatty acid oxidation, and increases glucose uptake and + utilization in target tissues. This lowers blood glucose levels. Metformin may + exert antineoplastic effects through AMPK-mediated or AMPK-independent inhibition + of mammalian target of rapamycin (mTOR), which is up-regulated in many cancer + tissues. It also reduces cyclin D1. This inhibits cancer cell proliferation. + Furthermore, this agent also inhibits tumor cell migration and invasion by inhibiting + matrix metalloproteinase-9 (MMP-9) expression which is mediated through the + suppression of transcription activator protein-1 (AP-1) activation. Also, metformin + reduces hyperinsulinemia which may contribute to an anti-tumor effect. Metformin + may increase the prostate-specific antigen (PSA) doubling time and may lower + serum PSA levels. + termDef: + term: >- + Extended Release Metformin Hydrochloride + source: NCIt + cde_id: C173523 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173523" + term_id: C173523 + term_version: 20.10d + +extension: + common: + description: >- + A mutation occurring within the stop codon of a gene that results in a sequence + that no longer encodes a stop codon and results in the transcription of non-coding + regions downstream of the gene. + termDef: + term: >- + Nonstop Mutation + source: NCIt + cde_id: C148650 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148650" + term_id: C148650 + term_version: 20.10d + +external_ear: + common: + description: >- + The external part of the ear. + termDef: + term: >- + External Ear + source: NCIt + cde_id: C12292 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12292" + term_id: C12292 + term_version: 20.05a + +external_lip_nos: + common: + description: >- + One of two visible fleshy folds that surround the orifice of the mouth. + termDef: + term: >- + External Lip + source: NCIt + cde_id: C12223 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12223" + term_id: C12223 + term_version: 20.05a + +external_lower_lip: + common: + description: >- + The external surface of the lower lip. + termDef: + term: >- + External Lower Lip + source: NCIt + cde_id: C12222 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12222" + term_id: C12222 + term_version: 20.05a + +external_upper_lip: + common: + description: >- + The external surface of the upper lip. + termDef: + term: >- + External Upper Lip + source: NCIt + cde_id: C12221 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12221" + term_id: C12221 + term_version: 20.05a + +extraabdominal_desmoid: + common: + description: >- + An insidious poorly circumscribed neoplasm arising from the soft tissues outside + the abdomen. It is characterized by the presence of elongated spindle-shaped + fibroblasts, vascular collagenous stroma formation, and an infiltrative growth + pattern. + termDef: + term: >- + Extraabdominal Fibromatosis + source: NCIt + cde_id: C6489 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6489" + term_id: C6489 + term_version: 20.05a + +extraadrenal_paraganglioma_malignant: + common: + description: >- + An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic + sites. Common sites of metastasis include the lymph nodes, lungs, bones, and + liver. + termDef: + term: >- + Malignant Extra-Adrenal Paraganglioma + source: NCIt + cde_id: C4219 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4219" + term_id: C4219 + term_version: 20.05a + +extraadrenal_paraganglioma_nos: + common: + description: >- + A benign or malignant paraganglioma arising from sympathetic or parasympathetic + paraganglia outside the adrenal gland. + termDef: + term: >- + Extra-Adrenal Paraganglioma + source: NCIt + cde_id: C3309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3309" + term_id: C3309 + term_version: 20.05a + +extracompartmental_t2: + common: + description: >- + Bone tumors extend beyond the bone cortex. + termDef: + term: >- + Extracompartmental Tumor + source: NCIt + cde_id: C140265 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140265" + term_id: C140265 + term_version: 20.05a + +extracutaneous_mastocytoma: + common: + description: >- + A localized tumor consisting of mature mast cells. (WHO, 2001) + termDef: + term: >- + Extracutaneous Mastocytoma + source: NCIt + cde_id: C7136 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7136" + term_id: C7136 + term_version: 20.05a + +extrahepatic_bile_duct: + common: + description: >- + The portion of the biliary tract outside the liver; the common hepatic duct + joins the cystic duct to form the common bile duct. + termDef: + term: >- + Extrahepatic Bile Duct + source: NCIt + cde_id: C32573 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32573" + term_id: C32573 + term_version: 20.05a + +extramural: + common: + description: >- + Happening or arising or located outside or beyond some limits, or especially, + some surface. + termDef: + term: >- + External + source: NCIt + cde_id: C44280 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C44280" + term_id: C44280 + term_version: 20.05a + +extranodal_marginal_zone_lymphoma_of_mucosaassociated_lymphoid_tissue: + common: + description: >- + An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes + (centrocyte-like cells). The gastrointestinal tract is the most common site + of involvement. Other common sites of involvement include lung, head and neck, + ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated + with the presence of H. pylori infection. (WHO, 2001) + termDef: + term: >- + Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue + source: NCIt + cde_id: C3898 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3898" + term_id: C3898 + term_version: 20.05a + +extranodal_nktcell_lymphoma_nasal_type: + common: + description: >- + An aggressive, predominantly extranodal, mature T-cell non-Hodgkin lymphoma. + It is characterized by an often angiocentric and angiodestructive cellular infiltrate + composed of EBV positive NK/T cells. The nasal cavity is the most common site + of involvement. Patients often present with midfacial destructive lesions (lethal + midline granuloma). The disease may disseminate rapidly to various anatomic + sites including the gastrointestinal tract, skin, testis, and cervical lymph + nodes. It is also known as angiocentric T-cell lymphoma. The term "polymorphic + reticulosis" has been widely used to describe the morphologic changes seen in + this type of lymphoma. However, the latter term may also apply to lymphomatoid + granulomatosis, which is an angiocentric and angiodestructive EBV positive B-cell + lymphoproliferative disorder. + termDef: + term: >- + Nasal Type Extranodal NK/T-Cell Lymphoma + source: NCIt + cde_id: C4684 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4684" + term_id: C4684 + term_version: 20.05a + +extraosseous_plasmacytoma: + common: + description: >- + A plasma cell neoplasm arising at an extraosseous site. There is no involvement + of the bone marrow. It most frequently involves the oropharynx, nasopharynx, + sinuses, and larynx. Other sites of involvement include the gastrointestinal + tract, central nervous system, breast, skin, lymph nodes, and bladder. A minority + of patients have a monoclonal gammopathy. Treatment includes radiation therapy. + Progression to plasma cell myeloma occurs in a minority of patients. + termDef: + term: >- + Extraosseous Plasmacytoma + source: NCIt + cde_id: C4002 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4002" + term_id: C4002 + term_version: 20.05a + +extraventricular_neurocytoma: + common: + description: >- + A WHO grade II neoplasm that arises from the brain parenchyma. Morphologically + it is characterized by the presence of neoplastic uniform, round cells with + neuronal differentiation. Unlike central neurocytoma, it does not involve the + lateral ventricles. It usually affects young adults and has a favorable prognosis. + termDef: + term: >- + Extraventricular Neurocytoma + source: NCIt + cde_id: C92555 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92555" + term_id: C92555 + term_version: 20.05a + +eye_nos: + common: + description: >- + The organ of sight or vision. + termDef: + term: >- + Eye + source: NCIt + cde_id: C12401 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12401" + term_id: C12401 + term_version: 20.05a + +eyelid: + common: + description: >- + A thin membrane of skin with the purpose of covering and protecting an eye. + termDef: + term: >- + Eyelid + source: NCIt + cde_id: C12713 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12713" + term_id: C12713 + term_version: 20.05a + +ezabenlimab: + common: + description: >- + A monoclonal antibody directed against the negative immunoregulatory human cell + surface receptor programmed cell death protein 1 (PD-1; PDCD1), with immune + checkpoint inhibitory and antineoplastic activities. Upon administration, ezabenlimab + selectively binds to and blocks the activation of PD-1, an immunoglobulin (Ig) + superfamily transmembrane protein, by its ligands programmed cell death ligand + 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell + death ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells + (APCs). This results in the activation of T-cells and T-cell-mediated immune + responses against tumor cells. Activated PD-1 negatively regulates T-cell activation + and plays a key role in in tumor evasion from host immunity. + termDef: + term: >- + Ezabenlimab + source: NCIt + cde_id: C132252 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132252" + term_id: C132252 + term_version: 20.10d + +ezh12_inhibitor_hh2853: + common: + description: >- + An orally bioavailable inhibitor of the histone lysine methyltransferases enhancer + of zeste homolog 1 (EZH1) and 2 (EZH2), with potential antineoplastic activity. + Upon oral administration, EZH1/2 inhibitor HH2853 inhibits the activity of both + wild-type and mutated forms of EZH1 and EZH2. Inhibition of EZH1/2 specifically + prevents the methylation of lysine 27 on histone H3 (H3K27). This decrease in + histone methylation alters gene expression patterns associated with cancer pathways, + enhances transcription of certain target genes, and results in decreased proliferation + of EZH1/2-expressing cancer cells. EZH1/2, histone lysine methyltransferase + (HMT) class enzymes and catalytic subunits of the polycomb repressive complex + 2 (PRC2), are overexpressed or mutated in a variety of cancer cells and play + key roles in tumor cell proliferation, progression, stem cell self-renewal and + migration. + termDef: + term: >- + EZH1/2 Inhibitor HH2853 + source: NCIt + cde_id: C173698 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173698" + term_id: C173698 + term_version: 20.10d + +ezh2: + common: + description: >- + This gene plays a role in chromatin remodeling and transcriptional regulation. + termDef: + term: >- + EZH2 Gene + source: NCIt + cde_id: C21327 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21327" + term_id: C21327 + term_version: 20.10d + +ezh2_inhibitor_cpi0209: + common: + description: >- + An orally available selective inhibitor of the histone lysine methyltransferase + (HMT) enhancer of zeste homolog 2 (EZH2), with potential antineoplastic activity. + Upon oral administration, EZH2 inhibitor CPI-0209 selectively targets, binds + to and inhibits the activity of EZH2. Inhibition of EZH2 specifically prevents + the methylation of histone H3 on lysine 27 (H3K27). This decrease in histone + methylation alters gene expression patterns associated with cancer pathways + and results in decreased proliferation of EZH2-expressing cancer cells. EZH2, + an HMT class enzyme and the catalytic subunit of the polycomb repressive complex + 2 (PRC2), is overexpressed or mutated in a variety of cancer cells and plays + a key role in tumor cell proliferation; its expression is correlated with tumor + initiation, progression, stem cell self-renewal, migration and angiogenesis. + termDef: + term: >- + EZH2 inhibitor CPI-0209 + source: NCIt + cde_id: C167347 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167347" + term_id: C167347 + term_version: 20.10d + +ezr: + common: + description: >- + This gene plays a role in cellular structure. + termDef: + term: >- + EZR Gene + source: NCIt + cde_id: C68722 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68722" + term_id: C68722 + term_version: 20.10d + +fab_l2: + common: + description: >- + An antiquated term that refers to acute lymphoblastic leukemia with large and + irregular lymphoblasts. + termDef: + term: >- + L2 Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27281 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27281" + term_id: C27281 + term_version: 20.05a + +fab_l3: + common: + description: >- + The leukemic counterpart of Burkitt's lymphoma. The characteristic Burkitt cells + are seen in the bone marrow and the peripheral blood. This is an aggressive + leukemia. + termDef: + term: >- + Burkitt Leukemia + source: NCIt + cde_id: C7400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7400" + term_id: C7400 + term_version: 20.05a + +fab_ll: + common: + description: >- + An acute lymphoblastic leukemia (current term: precursor lymphoblastic leukemia) + of B-or T-cell origin which according to the FAB classification is characterized + by the presence of more mature-appearing lymphoblasts. + termDef: + term: >- + L1 Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27290 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27290" + term_id: C27290 + term_version: 20.05a + +fab_m1: + common: + description: >- + An acute myeloid leukemia (AML) characterized by blasts without evidence of + maturation to more mature neutrophils. (WHO, 2001) + termDef: + term: >- + Acute Myeloid Leukemia without Maturation + source: NCIt + cde_id: C3249 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3249" + term_id: C3249 + term_version: 20.05a + +fab_m2_aml1cbfalphaeto: + common: + description: >- + An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 + fusion transcript and showing maturation in the neutrophil lineage. The bone + marrow and the peripheral blood show large myeloblasts with abundant basophilic + cytoplasm, often containing azurophilic granules. This type of AML is associated + with good response to chemotherapy and high complete remission rate. + termDef: + term: >- + Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 + source: NCIt + cde_id: C9288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9288" + term_id: C9288 + term_version: 20.05a + +fab_m2_nos: + common: + description: >- + An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation + to more mature neutrophils. (WHO, 2001) + termDef: + term: >- + Acute Myeloid Leukemia with Maturation + source: NCIt + cde_id: C3250 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3250" + term_id: C3250 + term_version: 20.05a + +fab_m2_t821q22q22: + common: + description: >- + An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 + fusion transcript and showing maturation in the neutrophil lineage. The bone + marrow and the peripheral blood show large myeloblasts with abundant basophilic + cytoplasm, often containing azurophilic granules. This type of AML is associated + with good response to chemotherapy and high complete remission rate. + termDef: + term: >- + Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 + source: NCIt + cde_id: C9288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9288" + term_id: C9288 + term_version: 20.05a + +fab_m3_includes_all_variants: + common: + description: >- + An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. + It is characterized by the PML-RARA fusion. There are two variants: the typical + and microgranular variant. This AML is particularly sensitive to treatment + with all trans-retinoic acid and has a favorable prognosis. (WHO) + termDef: + term: >- + Acute Promyelocytic Leukemia with PML-RARA + source: NCIt + cde_id: C3182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3182" + term_id: C3182 + term_version: 20.05a + +fab_m4: + common: + description: >- + An acute leukemia characterized by the proliferation of both neutrophil and + monocyte precursors. (WHO, 2001) + termDef: + term: >- + Acute Myelomonocytic Leukemia + source: NCIt + cde_id: C7463 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7463" + term_id: C7463 + term_version: 20.05a + +fab_m4eo: + common: + description: >- + Acute myelomonocytic leukemia characterized by the presence of abnormal bone + marrow eosinophils. It is associated with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22). + It has a favorable prognosis. + termDef: + term: >- + Acute Myelomonocytic Leukemia with Abnormal Eosinophils + source: NCIt + cde_id: C9020 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9020" + term_id: C9020 + term_version: 20.05a + +fab_m5_includes_all_variants: + common: + description: >- + An acute myeloid leukemia in which the majority of monocytic cells are promonocytes. (WHO, + 2001) + termDef: + term: >- + Acute Monocytic Leukemia + source: NCIt + cde_id: C4861 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4861" + term_id: C4861 + term_version: 20.05a + +fab_m6: + common: + description: >- + An acute myeloid leukemia characterized by a predominant immature erythroid + population. There are two subtypes recognized: erythroleukemia and pure erythroid + leukemia. (WHO, 2001) + termDef: + term: >- + Acute Erythroid Leukemia + source: NCIt + cde_id: C8923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8923" + term_id: C8923 + term_version: 20.05a + +fab_m7: + common: + description: >- + An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic + lineage. (WHO, 2001) + termDef: + term: >- + Acute Megakaryoblastic Leukemia + source: NCIt + cde_id: C3170 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3170" + term_id: C3170 + term_version: 20.05a + +fab_mo: + common: + description: >- + An acute myeloid leukemia (AML) in which the blasts do not show evidence of + myeloid differentiation by morphology and conventional cytochemistry. (WHO, + 2001) + termDef: + term: >- + Acute Myeloid Leukemia with Minimal Differentiation + source: NCIt + cde_id: C8460 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8460" + term_id: C8460 + term_version: 20.05a + +factory_smokestack_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates emitted + by a factory smokestack. + termDef: + term: >- + Factory Smokestack Smoke Exposure + source: NCIt + cde_id: C164081 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164081" + term_id: C164081 + term_version: 19.12e + +fadraciclib: + common: + description: >- + An orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9), + with potential antineoplastic and chemoprotective activities. Upon oral administration, + fadraciclib selectively binds to and inhibits the activity of CDK2, 5 and 9, + which leads to inhibition of CDK2, 5 and 9-dependent cellular pathways, downregulation + of genes involved in the pro-survival pathway, prevention of the activation + of DNA double-strand break repair pathways, and induction of both cell cycle + arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing + tumor cells. In addition, CYC065 protects hematopoietic stem and progenitor + cells (HSPCs), prevents myelosuppression, and preserves the function of the + bone marrow. CDKs are serine/threonine kinases involved in the regulation of + the cell cycle and may be overexpressed in certain cancer cell types; they play + key roles in tumor cell proliferation, the regulation of transcription, and + DNA damage repair. + termDef: + term: >- + Fadraciclib + source: NCIt + cde_id: C123902 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123902" + term_id: C123902 + term_version: 20.10d + +fakalkros1_inhibitor_apg2449: + common: + description: >- + An orally available kinase inhibitor of the receptor tyrosine kinase anaplastic + lymphoma kinase (ALK), focal adhesion kinase (FAK) and the receptor tyrosine + kinase C-ros oncogene 1 (ROS1), with potential antineoplastic activity. Upon + administration, ALK/FAK/ROS1 inhibitor APG-2449 selectively binds to and inhibits + ALK, FAK and ROS1 kinases. The inhibition leads to disruption of ALK-, FAK- + and ROS1-mediated signal transduction pathways and eventually inhibits tumor + cell growth in ALK-, FAK- and ROS1-overexpressing tumor cells. ALK belongs to + the insulin receptor superfamily and plays an important role in nervous system + development; its dysregulation and gene rearrangements are associated with a + variety of tumors. The cytoplasmic tyrosine kinase FAK, a signal transducer + for integrins, is upregulated and constitutively activated in various tumor + types; it plays a key role in tumor cell migration, proliferation, survival, + and tumor angiogenesis. ROS1, overexpressed in certain cancer cells, plays a + key role in cell growth and survival of cancer cells. + termDef: + term: >- + FAK/ALK/ROS1 Inhibitor APG-2449 + source: NCIt + cde_id: C172193 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172193" + term_id: C172193 + term_version: 20.10d + +falkland_islands_malvinas: + common: + description: >- + A group of islands in the South Atlantic Ocean, east of southern Argentina. + termDef: + term: >- + Falkland Islands (Malvinas) + source: NCIt + cde_id: C17954 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17954" + term_id: C17954 + term_version: 19.12e + +fallopian_tube: + common: + description: >- + One of a pair of tubes that extend from the uterus to each of the ovaries. Following + ovulation the egg travels down the fallopian tube to the uterus where fertilization + may or may not occur. + termDef: + term: >- + Fallopian Tube + source: NCIt + cde_id: C12403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12403" + term_id: C12403 + term_version: 20.05a + +fam131b: + common: + description: >- + This gene has not been characterized. + termDef: + term: >- + FAM131B Gene + source: NCIt + cde_id: C106340 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106340" + term_id: C106340 + term_version: 20.10d + +fam135b: + common: + description: >- + This gene may play a role in the metabolism of lipids. + termDef: + term: >- + FAM135B Gene + source: NCIt + cde_id: C143112 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143112" + term_id: C143112 + term_version: 20.10d + +fam46c: + common: + description: >- + This gene is involved in polyadenylation of RNA and mRNA stability. + termDef: + term: >- + TENT5C Gene + source: NCIt + cde_id: C96316 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96316" + term_id: C96316 + term_version: 20.10d + +fam47c: + common: + description: >- + This gene has no known function. + termDef: + term: >- + FAM47C Gene + source: NCIt + cde_id: C143109 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143109" + term_id: C143109 + term_version: 20.10d + +familial_polyposis_coli: + common: + description: >- + An autosomal dominant disorder, characterized by the presence of multiple adenomas + in the colon and rectum. It is caused by a germline mutation in the adenomatous + polyposis coli (APC) gene which is located on the long arm of chromosome 5. + The adenomas are most often tubular, and they have the tendency to progress + to adenocarcinoma. They can occur throughout the colon, but they tend to concentrate + in the rectum and sigmoid colon. The colorectal adenomas are detected during + endoscopic examination between the age of 10 and 20 years. The adenomas increase + in size and numbers with age, and there is usually progression of one or more + adenomas to adenocarcinoma. The mean age of development of adenocarcinoma is + about 40 years. Signs include rectal bleeding and mucousy diarrhea. + termDef: + term: >- + Familial Adenomatous Polyposis + source: NCIt + cde_id: C3339 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3339" + term_id: C3339 + term_version: 20.05a + +fanca: + common: + description: >- + This gene may be involved in the mediation of DNA repair. + termDef: + term: >- + FANCA Gene + source: NCIt + cde_id: C85995 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C85995" + term_id: C85995 + term_version: 20.10d + +fancc: + common: + description: >- + This gene may play a role in DNA cross-link repair. + termDef: + term: >- + FANCC Gene + source: NCIt + cde_id: C86025 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C86025" + term_id: C86025 + term_version: 20.10d + +fancd2: + common: + description: >- + This gene is involved in the regulation of meiosis, DNA repair and the cell + cycle. + termDef: + term: >- + FANCD2 Gene + source: NCIt + cde_id: C86549 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C86549" + term_id: C86549 + term_version: 20.10d + +fance: + common: + description: >- + This gene plays a role in the regulation of both DNA repair and protein localization. + termDef: + term: >- + FANCE Gene + source: NCIt + cde_id: C86551 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C86551" + term_id: C86551 + term_version: 20.10d + +fancf: + common: + description: >- + This gene may be involved in the regulation of DNA repair. + termDef: + term: >- + FANCF Gene + source: NCIt + cde_id: C86553 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C86553" + term_id: C86553 + term_version: 20.10d + +fancg: + common: + description: >- + This gene is involved in the maintenance of genomic integrity and nuclear signal + transduction. Allelic variants of the gene are involved in Fanconi syndrome. + termDef: + term: >- + FANCG Gene + source: NCIt + cde_id: C24385 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24385" + term_id: C24385 + term_version: 20.10d + +fap41bbtargeting_darpin_mp0310: + common: + description: >- + A designed ankyrin repeat proteins (DARPin)-based agent targeting the tumor-associated + protein fibroblast activation protein (FAP) and the T-cell co-stimulatory immune + receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; + TNFRSF9), with potential immunomodulating and antineoplastic activities. Upon + administration, the FAP/4-1BB-targeting DARPin MP0310 targets and binds to both + FAP, localized on tumor stromal cells, and 4-1BB, expressed on a variety of + leukocyte subsets including activated T-lymphocytes and natural killer (NK) + cells. The simultaneous binding of FAP and 4-1BB results in local clustering + of FAP-expressing tumor stromal cells and 4-1BB-expressing T-cells, and local + immune cell activation through the promotion of T-cell activation, cytokine + release and T-cell-mediated anti-tumor immune responses. 4-1BB, a surface glycoprotein + of the tumor necrosis factor receptor superfamily, is an inducible costimulatory + receptor that plays a key role in T-cell proliferation, survival and cytolytic + activity. FAP is abundantly expressed by cancer associated fibroblasts in the + majority of solid tumors. Compared to antibodies, DARPins are small in size, + have favorable pharmacokinetics and allow for both high affinity binding and + efficacy. + termDef: + term: >- + FAP/4-1BB-targeting DARPin MP0310 + source: NCIt + cde_id: C170894 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170894" + term_id: C170894 + term_version: 20.10d + +fap41bbtargeting_fusion_protein_ro7122290: + common: + description: >- + A bispecific antibody-like fusion protein consisting of a trimeric ligand for + the T-cell co-stimulatory immune receptor 4-1BB (CD137; tumor necrosis factor + receptor superfamily member 9; TNFRSF9) and an antigen-binding fragment (Fab) + moiety targeting the tumor-associated protein fibroblast activation protein + (FAP), with potential immunomodulating and antineoplastic activities. Upon administration, + the FAP/4-1BB-targeting fusion protein RO7122290 targets and binds to both FAP, + localized on tumor stromal cells, and 4-1BB, expressed on a variety of leukocyte + subsets including activated T-lymphocytes and natural killer (NK) cells. The + simultaneous binding of FAP and 4-1BB results in local clustering of FAP-expressing + tumor stromal cells and 4-1BB-expressing T-cells, and local immune cell activation + through the promotion of T-cell activation, cytokine release and T-cell-mediated + anti-tumor immune responses. 4-1BB, a surface glycoprotein of the tumor necrosis + factor receptor superfamily, is an inducible costimulatory receptor that plays + a key role in T-cell proliferation, survival and cytolytic activity. FAP is + abundantly expressed by cancer-associated fibroblasts in the majority of solid + tumors. + termDef: + term: >- + FAP/4-1BB-targeting Fusion Protein RO7122290 + source: NCIt + cde_id: C175490 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175490" + term_id: C175490 + term_version: 20.10d + +faroe_islands: + common: + description: >- + An island group between the Norwegian Sea and the North Atlantic Ocean, about + one-half of the way from Iceland to Norway. + termDef: + term: >- + Faroe Islands + source: NCIt + cde_id: C16573 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16573" + term_id: C16573 + term_version: 19.12e + +fas: + common: + description: >- + This gene is involved in the mediation of cellular surface receptors and apoptotic + signals. + termDef: + term: >- + FAS Gene + source: NCIt + cde_id: C21555 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21555" + term_id: C21555 + term_version: 20.10d + +fas_ligandtreated_allogeneic_mobilized_peripheral_blood_cells: + common: + description: >- + A donor graft derived from allogeneic filgrastim (granulocyte-colony stimulating + factor; G-CSF)-mobilized peripheral blood cells (MPBC) that have been incubated + with the recombinant human Fas ligand (FasL) APO010 ex vivo, and that can potentially + be used for immune reconstitution purposes. The incubation of the hematopoietic + stem cell graft with the apoptotic mediator Fas ligand (FasL) selectively induces + apoptosis of mature T-cells which express high levels of Fas receptor, such + as T stem cell memory (TSCM), T central memory (TCM), and T effector memory + (TEM) cells and the pro-inflammatory T-helper cells (Th) Th1 and Th17 subsets + while sparing CD34-positive stem and progenitor cells. Upon washing and further + ex vivo preparations, and upon allogeneic hematopoietic stem cell transplantation + (HSCT) with the FasL-treated allogeneic MPBCs, these cells provide hematopoietic + cell recovery, preserve the graft-versus-leukemia (GvL) effects, and may prevent + graft-versus-host disease (GvHD). + termDef: + term: >- + Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells + source: NCIt + cde_id: C167326 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167326" + term_id: C167326 + term_version: 20.10d + +fascial_fibroma: + common: + description: >- + A benign fibrous tumor arising from the fascial connective tissue. + termDef: + term: >- + Fascial Fibroma + source: NCIt + cde_id: C66764 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66764" + term_id: C66764 + term_version: 20.05a + +fascial_fibrosarcoma: + common: + description: >- + A malignant fibroblastic neoplasm arising from the fascial connective tissue. + termDef: + term: >- + Fascial Fibrosarcoma + source: NCIt + cde_id: C66765 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66765" + term_id: C66765 + term_version: 20.05a + +fat1: + common: + description: >- + This gene is involved in both cellular polarization and cell-cell adhesion. + termDef: + term: >- + FAT1 Gene + source: NCIt + cde_id: C18397 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18397" + term_id: C18397 + term_version: 20.10d + +fat3: + common: + description: >- + This gene is involved in cell adhesion and neurite development. + termDef: + term: >- + FAT3 Gene + source: NCIt + cde_id: C143133 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143133" + term_id: C143133 + term_version: 20.10d + +fat4: + common: + description: >- + This gene plays a role in planar cell polarity. + termDef: + term: >- + FAT4 Gene + source: NCIt + cde_id: C128254 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128254" + term_id: C128254 + term_version: 20.10d + +father: + common: + description: >- + A male parent. + termDef: + term: >- + Father + source: NCIt + cde_id: C25174 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25174" + term_id: C25174 + term_version: 19.12e + +fatherinlaw: + common: + description: >- + The father of your spouse. + termDef: + term: >- + Father-in-law + source: NCIt + cde_id: C68640 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68640" + term_id: C68640 + term_version: 19.12e + +favezelimab: + common: + description: >- + A humanized, immunoglobulin G4 (IgG4) monoclonal antibody (MAb) directed against + the inhibitory receptor lymphocyte activation gene-3 protein (LAG3), with potential + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + favezelimab binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) + and blocks its binding with major histocompatibility complex (MHC) class II + molecules expressed on tumor cells. This activates antigen-specific T-lymphocytes + and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads to a reduction + in tumor growth. LAG3, a member of the immunoglobulin superfamily (IgSF), is + expressed on various immune cells, and negatively regulates both proliferation + and activation of T-cells. Its expression on TILs is associated with tumor-mediated + immune suppression. + termDef: + term: >- + Favezelimab + source: NCIt + cde_id: C142077 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142077" + term_id: C142077 + term_version: 20.10d + +favorable: + common: + description: >- + Expressing something as positive, advantageous or desired. + termDef: + term: >- + Favorable + source: NCIt + cde_id: C102560 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102560" + term_id: C102560 + term_version: 20.05a + +fbln2: + common: + description: >- + This gene plays a role in protein-protein interactions in the extracellular + matrix. + termDef: + term: >- + FBLN2 Gene + source: NCIt + cde_id: C143130 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143130" + term_id: C143130 + term_version: 20.10d + +fbxo11: + common: + description: >- + This gene plays a role in the recognition of proteins to be ubiquitinylated. + termDef: + term: >- + FBXO11 Gene + source: NCIt + cde_id: C101104 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101104" + term_id: C101104 + term_version: 20.10d + +fbxw7: + common: + description: >- + This gene is involved in ubiquitin-dependent proteolysis and regulation of the + G1-S cell cycle checkpoint. + termDef: + term: >- + FBXW7 Gene + source: NCIt + cde_id: C20786 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20786" + term_id: C20786 + term_version: 20.10d + +fcengineered_anticd40_agonist_antibody_2141v11: + common: + description: >- + A Fc-engineered agonistic antibody targeting the human B-cell surface antigen + CD40, with potential immunostimulatory and antineoplastic activities. Upon intratumoral + administration, 2141-V11 targets and binds to CD40 on a variety of immune cell + types. This induces CD40-dependent signaling pathways, triggers the proliferation + and activation of antigen-presenting cells (APCs) and activates T-cells. This + results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response + against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis + factor receptor superfamily (TNFRSF), is expressed on various immune cells, + such as dendritic cells (DCs), macrophages and B-cells, and plays a key role + in the activation of the immune system. + termDef: + term: >- + Fc-engineered Anti-CD40 Agonist Antibody 2141-V11 + source: NCIt + cde_id: C170762 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170762" + term_id: C170762 + term_version: 20.10d + +fcgr2b: + common: + description: >- + This gene plays a role in the inhibition of immune functions and cellular proliferation. + termDef: + term: >- + FCGR2B Gene + source: NCIt + cde_id: C38554 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38554" + term_id: C38554 + term_version: 20.10d + +fcrl4: + common: + description: >- + This gene may be involved in B cell receptor signaling. + termDef: + term: >- + FCRL4 Gene + source: NCIt + cde_id: C97592 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97592" + term_id: C97592 + term_version: 20.10d + +feature_elongation: + common: + description: >- + The mutation of either a splice site or stop codon that leads to an extended + transcript. + termDef: + term: >- + Elongation Mutation + source: NCIt + cde_id: C148640 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148640" + term_id: C148640 + term_version: 20.10d + +feature_truncation: + common: + description: >- + The mutation of either a splice site or stop codon that leads to a truncated + transcript. + termDef: + term: >- + Truncation Mutation + source: NCIt + cde_id: C148641 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148641" + term_id: C148641 + term_version: 20.10d + +feces: + common: + description: >- + The material discharged from the bowel during defecation. It consists of undigested + food, intestinal mucus, epithelial cells, and bacteria. + termDef: + term: >- + Feces + source: NCIt + cde_id: C13234 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13234" + term_id: C13234 + term_version: 20.10d + +federated_states_of_micronesia: + common: + description: >- + An island group in the North Pacific Ocean, about three-quarters of the way + from Hawaii to Indonesia, west of the Marshall Islands and north of the Solomon + Islands. + termDef: + term: >- + Federated States of Micronesia + source: NCIt + cde_id: C17881 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17881" + term_id: C17881 + term_version: 19.12e + +feladilimab: + common: + description: >- + An agonistic antibody for the inducible T-cell co-stimulator (ICOS; CD278), + with potential immune checkpoint inhibitory and antineoplastic activities. Upon + administration, feladilimab targets and binds to ICOS expressed on tumor infiltrating + CD4-positive T-cells. This stimulates ICOS-positive T-cell proliferation, enhances + cytotoxic T-lymphocyte (CTL) survival and increases CTL-mediated immune responses + against tumor cells. ICOS, a T-cell specific, CD28-superfamily costimulatory + molecule and immune checkpoint protein, is normally expressed on certain activated + T-cells and plays a key role in the proliferation and activation of T-cells. + termDef: + term: >- + Feladilimab + source: NCIt + cde_id: C126804 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126804" + term_id: C126804 + term_version: 20.10d + +felzartamab: + common: + description: >- + A fully human monoclonal antibody directed against the cell surface glycoprotein + CD-38 with potential antineoplastic activity. Felzartamab specifically binds + to CD38 on CD38-positive tumor cells. This may trigger antitumoral antibody-dependent + cellular cytotoxicity (ADCC) and may eventually lead to cell lysis in CD38-expressing + tumor cells. CD38, a type II transmembrane glycoprotein, is present on various + immune cells and hematologic malignancies, and its expression has been correlated + with poor prognosis. + termDef: + term: >- + Felzartamab + source: NCIt + cde_id: C97954 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97954" + term_id: C97954 + term_version: 20.10d + +female: + common: + description: >- + A person who belongs to the sex that normally produces ova. The term is used + to indicate biological sex distinctions, or cultural gender role distinctions, + or both. + termDef: + term: >- + Female + source: NCIt + cde_id: C16576 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16576" + term_id: C16576 + term_version: 19.12e + +female_cousin: + common: + description: >- + A female child of one's aunt or uncle. + termDef: + term: >- + Female Cousin + source: NCIt + cde_id: C165786 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165786" + term_id: C165786 + term_version: 19.12e + +female_genital_tract_nos: + common: + description: >- + The external female sexual organs. + termDef: + term: >- + Female Genitalia + source: NCIt + cde_id: C61600 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61600" + term_id: C61600 + term_version: 20.05a + +female_sibling_of_adopted_child: + common: + description: >- + A female sibling of an adopted child. The said female is a biological or legal + child of the parents who facilitated the adoption. + termDef: + term: >- + Female Sibling of Adopted Child + source: NCIt + cde_id: C166198 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166198" + term_id: C166198 + term_version: 19.12e + +femoral: + common: + description: >- + A lymph node located in the upper inner portion of the thigh. + termDef: + term: >- + Femoral Lymph Node + source: NCIt + cde_id: C98183 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98183" + term_id: C98183 + term_version: 20.10d + +fen1: + common: + description: >- + This gene is involved in DNA replication and repair. + termDef: + term: >- + FEN1 Gene + source: NCIt + cde_id: C98120 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98120" + term_id: C98120 + term_version: 20.10d + +fenretinide_phospholipid_suspension_st001: + common: + description: >- + An intravenous formulation composed of a phospholipid suspension of nanoparticles + containing the synthetic retinoid derivative fenretinide, with potential antineoplastic + activity. Upon intravenous administration, fenretinide binds to and activates + retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis + in susceptible tumor cell types. Fenretinide also binds to and inhibits the + activity of mammalian target of rapamycin (mTOR), which may result in both the + induction of tumor cell apoptosis and a decrease in tumor cell proliferation. + Independent of RAR activation and mTOR inhibition, this agent may also modulate + gene expression that leads to ceramide-induced, caspase-independent programmed + cell death (PCD) via effectors such as ganglioside GD3 and reactive oxygen species + (ROS). + termDef: + term: >- + Fenretinide Phospholipid Suspension ST-001 + source: NCIt + cde_id: C175469 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175469" + term_id: C175469 + term_version: 20.10d + +fes: + common: + description: >- + This gene is involved in hematopoiesis and the maintenance of cellular transformation. + termDef: + term: >- + FES Gene + source: NCIt + cde_id: C45497 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45497" + term_id: C45497 + term_version: 20.10d + +fetal_adenocarcinoma: + common: + description: >- + A rare morphologic variant of lung adenocarcinoma characterized by the presence + of glandular structures containing glycogen-rich cells forming tubules that + resemble fetal lung tubules. + termDef: + term: >- + Lung Fetal Adenocarcinoma + source: NCIt + cde_id: C45509 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45509" + term_id: C45509 + term_version: 20.05a + +fetal_adenoma: + common: + description: >- + A thyroid gland adenoma composed of microfollicular structures. + termDef: + term: >- + Thyroid Gland Microfollicular Adenoma + source: NCIt + cde_id: C4160 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4160" + term_id: C4160 + term_version: 20.05a + +fetal_fat_cell_lipoma: + common: + description: >- + A rare benign slow growing adipose tissue tumor, characterized by the presence + of polygonal brown fat cells with multivacuolated and/or granular cytoplasm. The + tumor is usually painless and is most often seen in young adults. + termDef: + term: >- + Hibernoma + source: NCIt + cde_id: C3702 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3702" + term_id: C3702 + term_version: 20.05a + +fetal_lipoma_nos: + common: + description: >- + A lipoma usually occurring in the extremities of young children (usually boys). + It is characterized by lobules of adipose tissue, separated by fibrous septa. The + adipose tissue is composed of mature adipocytes and lipoblasts. The lipoblasts + may be scarce, depending on the age of the patient. + termDef: + term: >- + Lipoblastoma + source: NCIt + cde_id: C27483 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27483" + term_id: C27483 + term_version: 20.05a + +fetal_lipomatosis: + common: + description: >- + A benign disorder characterized by the presence of multiple lipoblastomas. + termDef: + term: >- + Lipoblastomatosis + source: NCIt + cde_id: C4255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4255" + term_id: C4255 + term_version: 20.05a + +fetal_rhabdomyoma: + common: + description: >- + A rare benign mesenchymal neoplasm arising from skeletal muscle. It is characterized + by the presence of immature spindle and polygonal cells within a scant myxoid + stroma. It usually develops in the head and neck region of young children. + termDef: + term: >- + Fetal Rhabdomyoma + source: NCIt + cde_id: C4260 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4260" + term_id: C4260 + term_version: 20.05a + +fev: + common: + description: >- + This gene may play a role in transcriptional repression. + termDef: + term: >- + FEV Gene + source: NCIt + cde_id: C97482 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97482" + term_id: C97482 + term_version: 20.10d + +fgfr_inhibitor_cpl304110: + common: + description: >- + An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR), + with potential antineoplastic activity. Upon oral administration, FGFR inhibitor + CPL304110 binds to and inhibits FGFR, which results in the inhibition of FGFR-mediated + signal transduction pathways. This inhibits proliferation in FGFR-overexpressing + tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many + tumor cell types, plays a key role in cellular proliferation and survival. + termDef: + term: >- + FGFR Inhibitor CPL304110 + source: NCIt + cde_id: C173964 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173964" + term_id: C173964 + term_version: 20.10d + +fgfr1: + common: + description: >- + This gene plays a role in mitogenesis and differentiation. + termDef: + term: >- + FGFR1 Gene + source: NCIt + cde_id: C19929 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19929" + term_id: C19929 + term_version: 20.10d + +fgfr1op: + common: + description: >- + This gene is involved in the regulation of cell shape, polarity and motility. + termDef: + term: >- + FGFR1OP Gene + source: NCIt + cde_id: C24401 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24401" + term_id: C24401 + term_version: 20.10d + +fgfr2: + common: + description: >- + This gene plays a role in mitogenesis and differentiation and mutations in the + gene are associated with craniosynostotic syndromes and bone malformations. + termDef: + term: >- + FGFR2 Gene + source: NCIt + cde_id: C19931 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19931" + term_id: C19931 + term_version: 20.10d + +fgfr2_inhibitor_rly4008: + common: + description: >- + An orally bioavailable inhibitor of the fibroblast growth factor receptor 2 + (FGFR2), with potential antineoplastic activity. Upon oral administration, FGFR2 + inhibitor RLY-4008 binds to and inhibits FGFR2, which results in the inhibition + of FGFR2-mediated signal transduction pathways. This inhibits the proliferation + of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated + in many tumor cell types, plays a key role in cellular proliferation, migration + and survival. + termDef: + term: >- + FGFR2 Inhibitor RLY-4008 + source: NCIt + cde_id: C174208 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174208" + term_id: C174208 + term_version: 20.10d + +fgfr3: + common: + description: >- + This gene plays a role in bone development and maintenance and mutations in + the gene are associated with craniosynostosis and several types of skeletal + dysplasia. + termDef: + term: >- + FGFR3 Gene + source: NCIt + cde_id: C24393 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24393" + term_id: C24393 + term_version: 20.10d + +fgfr4: + common: + description: >- + This gene plays a role in mitogenesis and differentiation. + termDef: + term: >- + FGFR4 Gene + source: NCIt + cde_id: C20743 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20743" + term_id: C20743 + term_version: 20.10d + +fgfrcsf1r_inhibitor_3d185: + common: + description: >- + An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) + types 1, 2, and 3 (FGFR1/2/3) and colony stimulating factor 1 receptor (CSF1R; + CSF-1R; CD115; M-CSFR), with potential immunomodulatory and antineoplastic activities. + Upon administration, FGFR/CSF-1R inhibitor 3D185 binds to and inhibits FGFR1/2/3, + which may result in the inhibition of FGFR1/2/3-mediated signal transduction + pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. + 3D185 also targets and binds to CSF1R, thereby blocking CSF1R activation and + CSF1R-mediated signaling. This inhibits the activities of tumor-associated macrophages + (TAMs) and myeloid-derived suppressor cells (MDSCs), and prevents immune suppression + in the tumor microenvironment (TME). This enhances antitumor T-cell immune responses + and inhibits the proliferation of tumor cells. FGFR, a family of receptor tyrosine + kinases (RTKs) upregulated in many tumor cell types, plays a key role in cellular + proliferation, migration and survival. CSF1R, also known as macrophage colony-stimulating + factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface + receptor that plays major roles in tumor cell proliferation and metastasis. + termDef: + term: >- + FGFR/CSF-1R Inhibitor 3D185 + source: NCIt + cde_id: C175460 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175460" + term_id: C175460 + term_version: 20.10d + +fh: + common: + description: >- + This gene plays a role in the Krebs cycle. + termDef: + term: >- + FH Gene + source: NCIt + cde_id: C95268 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95268" + term_id: C95268 + term_version: 20.10d + +fhit: + common: + description: >- + This gene is involved in nucleotide metabolism and cell cycle control. + termDef: + term: >- + FHIT Gene + source: NCIt + cde_id: C18524 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18524" + term_id: C18524 + term_version: 20.10d + +fianlimab: + common: + description: >- + A monoclonal antibody directed against the inhibitory receptor lymphocyte activation + gene-3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory + and antineoplastic activities. Upon administration, fianlimab binds to LAG-3 + expressed by tumor infiltrating lymphocytes (TILs) and blocks LAG-3 binding + to tumor cells expressing major histocompatibility complex (MHC) class II molecules. + This may activate antigen-specific T-lymphocytes and enhance cytotoxic T-lymphocyte + (CTL)-mediated tumor cell lysis, which leads to a reduction in tumor growth. + LAG-3, a member of the immunoglobulin superfamily (IgSF), is expressed on various + immune cells; its expression on TILs is associated with tumor-mediated immune + suppression and the negative regulation of both cellular proliferation and T-cell + activation. + termDef: + term: >- + Fianlimab + source: NCIt + cde_id: C132339 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132339" + term_id: C132339 + term_version: 20.10d + +fibrillary_astrocytoma: + common: + description: >- + The most frequent histological variant of diffuse astrocytoma. It is predominantly + composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic + criterion but mitotic activity, necrosis and microvascular proliferation are + absent. The occasional or regional occurrence of gemistocytic neoplastic cells + is compatible with the diagnosis of fibrillary astrocytoma. (WHO) + termDef: + term: >- + Fibrillary Astrocytoma + source: NCIt + cde_id: C4322 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4322" + term_id: C4322 + term_version: 20.05a + +fibroadenoma_nos: + common: + description: >- + A benign tumor of the breast characterized by the presence of stromal and epithelial + elements. It presents as a painless, solitary, slow growing, firm, and mobile + mass. It is the most common benign breast lesion. It usually occurs in women + of childbearing age. The majority of fibroadenomas do not recur after complete + excision. A slightly increased risk of developing cancer within fibroadenomas + or in the breast tissue of patients previously treated for fibroadenomas has + been reported. + termDef: + term: >- + Breast Fibroadenoma + source: NCIt + cde_id: C3744 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3744" + term_id: C3744 + term_version: 20.05a + +fibroameloblastic_odontoma: + common: + description: >- + A rare benign neoplasm arising from tooth-forming tissues. It is characterized + by the presence of a fibromyxoid stroma, epithelial component, dentin, and enamel. + Recurrences are rare. + termDef: + term: >- + Ameloblastic Fibro-Odontoma + source: NCIt + cde_id: C3710 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3710" + term_id: C3710 + term_version: 20.05a + +fibroblastic_liposarcoma: + common: + description: >- + A liposarcoma characterized by the presence of a fibroblastic component. + termDef: + term: >- + Fibroblastic Liposarcoma + source: NCIt + cde_id: C6509 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6509" + term_id: C6509 + term_version: 20.05a + +fibroblastic_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of spindle cells that + form bundles in a collagen matrix. + termDef: + term: >- + Fibrous Meningioma + source: NCIt + cde_id: C4330 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4330" + term_id: C4330 + term_version: 20.05a + +fibroblastic_osteosarcoma: + common: + description: >- + A conventional osteosarcoma characterized by the presence of spindle shaped + cells. + termDef: + term: >- + Fibroblastic Osteosarcoma + source: NCIt + cde_id: C4020 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4020" + term_id: C4020 + term_version: 20.05a + +fibroblastic_reticular_cell_tumor: + common: + description: >- + A very rare dendritic cell tumor affecting the lymph nodes, spleen, and soft + tissues. Morphologically it is similar to the interdigitating dendritic cell + sarcoma or follicular dendritic cell sarcoma. The tumor cells are positive for + cytokeratin and CD68. Clinical outcome is variable. + termDef: + term: >- + Fibroblastic Reticular Cell Tumor + source: NCIt + cde_id: C81758 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81758" + term_id: C81758 + term_version: 20.05a + +fibrochondrosarcoma: + common: + description: >- + A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from + the bone and soft tissue. It usually affects middle-aged to elderly adults. The + pelvic bones, ribs, shoulder girdle, and long bones are the most common sites + of involvement. Most chondrosarcomas arise de novo, but some may develop in + a preexisting benign cartilaginous lesion. + termDef: + term: >- + Chondrosarcoma + source: NCIt + cde_id: C2946 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2946" + term_id: C2946 + term_version: 20.05a + +fibroepithelial_basal_cell_carcinoma_pinkus_type: + common: + description: >- + A variant of basal cell carcinoma presenting as an elevated or erythematous + nodular lesion usually in the back. Morphologically, it is characterized by + the presence of cords of basaloid cells extending from the epidermis into the + dermis, creating a fenestrating pattern. It follows an indolent course. + termDef: + term: >- + Skin Fibroepithelial Basal Cell Carcinoma + source: NCIt + cde_id: C4109 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4109" + term_id: C4109 + term_version: 20.05a + +fibroepithelioma_nos: + common: + description: >- + A variant of basal cell carcinoma presenting as an elevated or erythematous + nodular lesion usually in the back. Morphologically, it is characterized by + the presence of cords of basaloid cells extending from the epidermis into the + dermis, creating a fenestrating pattern. It follows an indolent course. + termDef: + term: >- + Skin Fibroepithelial Basal Cell Carcinoma + source: NCIt + cde_id: C4109 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4109" + term_id: C4109 + term_version: 20.05a + +fibroepithelioma_of_pinkus_type: + common: + description: >- + A variant of basal cell carcinoma presenting as an elevated or erythematous + nodular lesion usually in the back. Morphologically, it is characterized by + the presence of cords of basaloid cells extending from the epidermis into the + dermis, creating a fenestrating pattern. It follows an indolent course. + termDef: + term: >- + Skin Fibroepithelial Basal Cell Carcinoma + source: NCIt + cde_id: C4109 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4109" + term_id: C4109 + term_version: 20.05a + +fibrofolliculoma: + common: + description: >- + A rare, pilar-associated mesenchyme neoplasm with follicular differentiation. + It usually occurs in the face, neck, and chest. It presents as a dome-shaped + papular lesion. It is composed of epithelial and mesenchymal cells. Patients + with Birt-Hogg-Dube syndrome may develop follicular fibromas. + termDef: + term: >- + Fibrofolliculoma + source: NCIt + cde_id: C43331 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43331" + term_id: C43331 + term_version: 20.05a + +fibroid_uterus: + common: + description: >- + A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized + by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, + and a whorled pattern. + termDef: + term: >- + Uterine Corpus Leiomyoma + source: NCIt + cde_id: C3434 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3434" + term_id: C3434 + term_version: 20.05a + +fibrolipoma: + common: + description: >- + A benign well-circumscribed tumor composed of mature adipocytes, characterized + by areas of abundant fibrous tissue. + termDef: + term: >- + Fibrolipoma + source: NCIt + cde_id: C4249 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4249" + term_id: C4249 + term_version: 20.05a + +fibroliposarcoma: + common: + description: >- + A usually painless malignant tumor that arises from adipose tissue. Microscopically, + it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to + pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, + dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential + is higher in less differentiated tumors. + termDef: + term: >- + Liposarcoma + source: NCIt + cde_id: C3194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3194" + term_id: C3194 + term_version: 20.05a + +fibroma_nos: + common: + description: >- + A non-metastasizing neoplasm arising from the fibrous tissue. It is characterized + by the presence of spindle-shaped fibroblasts. + termDef: + term: >- + Fibroma + source: NCIt + cde_id: C3041 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3041" + term_id: C3041 + term_version: 20.05a + +fibromyoma: + common: + description: >- + A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized + by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, + and a whorled pattern. + termDef: + term: >- + Uterine Corpus Leiomyoma + source: NCIt + cde_id: C3434 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3434" + term_id: C3434 + term_version: 20.05a + +fibromyxolipoma: + common: + description: >- + A benign well-circumscribed tumor composed of mature adipocytes, characterized + by areas of abundant fibrous tissue and extensive myxoid change. + termDef: + term: >- + Fibromyxolipoma + source: NCIt + cde_id: C4251 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4251" + term_id: C4251 + term_version: 20.05a + +fibromyxoma: + common: + description: >- + A soft tissue tumor of uncertain lineage characterized by the presence of neoplastic + spindle-shaped to round cells in a fibromyxoid stroma. Metaplastic bone formation + may or may not be present. + termDef: + term: >- + Fibromyxoid Tumor + source: NCIt + cde_id: C66760 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66760" + term_id: C66760 + term_version: 20.05a + +fibromyxosarcoma: + common: + description: >- + A malignant fibroblastic neoplasm arising from the soft tissue. It is characterized + by the presence of spindle-shaped cells, cellular pleomorphism, thin-walled + blood vessels, fibrous septa, and myxoid stroma. + termDef: + term: >- + Myxofibrosarcoma + source: NCIt + cde_id: C6496 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6496" + term_id: C6496 + term_version: 20.05a + +fibroosteoma: + common: + description: >- + A well circumscribed lesion of the bone, most frequently arising from the posterior + mandible. It is characterized by the presence of fibrous tissue and a mineralized + component which may be woven bone, lamellar bone, or cementum-like material. + Complete removal is recommended, since it continues to enlarge if left untreated. + termDef: + term: >- + Ossifying Fibroma + source: NCIt + cde_id: C8422 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8422" + term_id: C8422 + term_version: 20.05a + +fibrosarcoma_nos: + common: + description: >- + A malignant mesenchymal fibroblastic neoplasm affecting the soft tissue and + bone. + termDef: + term: >- + Fibrosarcoma + source: NCIt + cde_id: C3043 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3043" + term_id: C3043 + term_version: 20.05a + +fibrosarcomatous_dermatofibrosarcoma_protuberans: + common: + description: >- + A morphologic variant of dermatofibrosarcoma protuberans characterized by the + presence of a fibrosarcomatous component. + termDef: + term: >- + Fibrosarcomatous Dermatofibrosarcoma Protuberans + source: NCIt + cde_id: C27547 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27547" + term_id: C27547 + term_version: 20.05a + +fibrous_astrocytoma: + common: + description: >- + The most frequent histological variant of diffuse astrocytoma. It is predominantly + composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic + criterion but mitotic activity, necrosis and microvascular proliferation are + absent. The occasional or regional occurrence of gemistocytic neoplastic cells + is compatible with the diagnosis of fibrillary astrocytoma. (WHO) + termDef: + term: >- + Fibrillary Astrocytoma + source: NCIt + cde_id: C4322 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4322" + term_id: C4322 + term_version: 20.05a + +fibrous_histiocytoma_nos: + common: + description: >- + A benign neoplasm composed of fibroblastic spindle cells in a whorled storiform + pattern. It is characterized by the presence of foam cells, inflammatory cells, + hemosiderin deposition and stromal hemorrhage. + termDef: + term: >- + Benign Fibrous Histiocytoma + source: NCIt + cde_id: C3739 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3739" + term_id: C3739 + term_version: 20.05a + +fibrous_histiocytoma_of_tendon_sheath: + common: + description: >- + A tumor usually arising in the synovium of joints, bursa or tendon sheath. It + is characterized by the presence of mononuclear cells, multinucleated osteoclast-like + giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory + infiltrate. According to the growth pattern, it is classified as localized or + diffuse. + termDef: + term: >- + Tenosynovial Giant Cell Tumor + source: NCIt + cde_id: C3402 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3402" + term_id: C3402 + term_version: 20.05a + +fibrous_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of spindle cells that + form bundles in a collagen matrix. + termDef: + term: >- + Fibrous Meningioma + source: NCIt + cde_id: C4330 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4330" + term_id: C4330 + term_version: 20.05a + +fibrous_mesothelioma_benign: + common: + description: >- + A localized neoplasm of probable fibroblastic derivation, that arises from the + pleura. It is characterized by the presence of round to spindle-shaped cells, + hylanized stroma formation, thin-walled branching blood vessels, and thin bands + of collagen. + termDef: + term: >- + Pleural Solitary Fibrous Tumor + source: NCIt + cde_id: C4457 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4457" + term_id: C4457 + term_version: 20.05a + +fibrous_mesothelioma_malignant: + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of spindle cells. Anaplastic morphologic features and multinucleated + malignant cells may also be seen. + termDef: + term: >- + Sarcomatoid Mesothelioma + source: NCIt + cde_id: C45655 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45655" + term_id: C45655 + term_version: 20.05a + +fibrous_mesothelioma_nos: + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of spindle cells. Anaplastic morphologic features and multinucleated + malignant cells may also be seen. + termDef: + term: >- + Sarcomatoid Mesothelioma + source: NCIt + cde_id: C45655 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45655" + term_id: C45655 + term_version: 20.05a + +fibroxanthoma_malignant: + common: + description: >- + An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic + malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma. + termDef: + term: >- + Undifferentiated Pleomorphic Sarcoma + source: NCIt + cde_id: C4247 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4247" + term_id: C4247 + term_version: 20.05a + +fibroxanthoma_nos: + common: + description: >- + A benign neoplasm composed of fibroblastic spindle cells in a whorled storiform + pattern. It is characterized by the presence of foam cells, inflammatory cells, + hemosiderin deposition and stromal hemorrhage. + termDef: + term: >- + Benign Fibrous Histiocytoma + source: NCIt + cde_id: C3739 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3739" + term_id: C3739 + term_version: 20.05a + +field_burning_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when trees, brush and grass in a field are burning. + termDef: + term: >- + Field Burning Smoke Exposure + source: NCIt + cde_id: C164082 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164082" + term_id: C164082 + term_version: 19.12e + +fiji: + common: + description: >- + A group of islands in the South Pacific Ocean, southwest of Wallis and Fortuna + and east of Vanuatu. + termDef: + term: >- + Fiji + source: NCIt + cde_id: C16582 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16582" + term_id: C16582 + term_version: 19.12e + +fimaporfin_a: + common: + description: >- + The A isomer of fimaporfin, a synthetic light-activated compound, with potential + photosensitizing activity. Upon administration, fimaporfin A incorporates into + the cell's endosome and lysosome membranes. Subsequently, cytotoxic agents are + administered and accumulate in endosomal and lysosomal compartments; upon local + activation by light, fimaporfin A produces reactive oxygen species (ROS), such + as singlet oxygen, damaging endo/lysosomal membranes and accumulated cytotoxic + agents are released into the tumor cell cytosol. This photochemical internalization + (PCI) method can enhance the efficacy and selectivity of cytotoxic agents. + termDef: + term: >- + Fimaporfin A + source: NCIt + cde_id: C88344 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C88344" + term_id: C88344 + term_version: 20.10d + +fine_needle_aspiration: + common: + description: >- + A surgical procedure in which an entire lesion is removed for microscopic examination. + termDef: + term: >- + Fine-Needle Aspiration + source: NCIt + cde_id: C15361 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15361" + term_id: C15361 + term_version: 20.05a + +finland: + common: + description: >- + A country in northern Europe, bordering the Baltic Sea, between Sweden and Russia. + termDef: + term: >- + Finland + source: NCIt + cde_id: C16584 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16584" + term_id: C16584 + term_version: 19.12e + +fip1l1: + common: + description: >- + This gene is involved in mRNA processing. + termDef: + term: >- + FIP1L1 Gene + source: NCIt + cde_id: C97454 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97454" + term_id: C97454 + term_version: 20.10d + +fire_smoke_nos: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when materials are rapidly oxidized via combustion. + termDef: + term: >- + Fire Smoke Exposure + source: NCIt + cde_id: C164058 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164058" + term_id: C164058 + term_version: 19.12e + +first_cousin: + common: + description: >- + A child of your aunt or uncle. + termDef: + term: >- + First Cousin + source: NCIt + cde_id: C71411 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71411" + term_id: C71411 + term_version: 19.12e + +first_cousin_once_removed: + common: + description: >- + A child of your first cousin. + termDef: + term: >- + First Cousin Once Removed + source: NCIt + cde_id: C71412 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71412" + term_id: C71412 + term_version: 19.12e + +fish: + common: + description: >- + A physical mapping approach that uses fluorescent tags to detect hybridization + of probes within metaphase chromosomes or less condensed somatic interphase + chromatin. This technique can be used for identification of chromosomal abnormalities + and for gene mapping. + termDef: + term: >- + Fluorescence In Situ Hybridization + source: NCIt + cde_id: C17563 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17563" + term_id: C17563 + term_version: 20.10d + +fkbp9: + common: + description: >- + This gene is involved in chaperone-mediated protein folding. + termDef: + term: >- + FKBP9 Gene + source: NCIt + cde_id: C143127 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143127" + term_id: C143127 + term_version: 20.10d + +flat_adenoma: + common: + description: >- + An adenoma of the gastrointestinal tract mucosa which grossly and morphologically + does not appear as an elevated or polypoid lesion. + termDef: + term: >- + Flat Adenoma + source: NCIt + cde_id: C65193 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65193" + term_id: C65193 + term_version: 20.05a + +flcn: + common: + description: >- + This gene may play a role in tumor suppression. + termDef: + term: >- + FLCN Gene + source: NCIt + cde_id: C63514 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63514" + term_id: C63514 + term_version: 20.10d + +fli1: + common: + description: >- + This gene plays a role in transcriptional activation and has been implicated + in the pathogenesis of neuroepithelioma. + termDef: + term: >- + FLI1 Gene + source: NCIt + cde_id: C18321 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18321" + term_id: C18321 + term_version: 20.10d + +flna: + common: + description: >- + This gene is involved in remodeling of the cytoskeleton. + termDef: + term: >- + FLNA Gene + source: NCIt + cde_id: C113585 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113585" + term_id: C113585 + term_version: 20.10d + +floor_of_mouth_nos: + common: + description: >- + The area of the mouth under the ventral surface of the tongue. + termDef: + term: >- + Floor of Mouth + source: NCIt + cde_id: C54187 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54187" + term_id: C54187 + term_version: 20.05a + +florid_osseous_dysplasia: + common: + description: >- + A rare, benign, slow growing, multifocal, and expansile lesion of the jaws. + Both familiar and sporadic cases have been reported. It is characterized by + a fibroblastic proliferation, cementum, and limited bone formation. + termDef: + term: >- + Gigantiform Cementoma + source: NCIt + cde_id: C8381 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8381" + term_id: C8381 + term_version: 20.05a + +flow_cytometry: + common: + description: >- + A technique for counting, examining and sorting microscopic particles suspended + in a stream of fluid. + termDef: + term: >- + Flow Cytometry + source: NCIt + cde_id: C16585 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16585" + term_id: C16585 + term_version: 20.10d + +flt3: + common: + description: >- + This gene plays a role in hematopoiesis and may function as a growth factor + receptor. + termDef: + term: >- + FLT3 Gene + source: NCIt + cde_id: C24399 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24399" + term_id: C24399 + term_version: 20.10d + +flt3_ligandantictla4_antibodyil12_engineered_oncolytic_vaccinia_virus_rival01: + common: + description: >- + An oncolytic vaccinia virus (VV; VACV) genetically engineered to express an + Fms-like tyrosine kinase 3 (Flt3) ligand, an antibody directed against the human + T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) + and the human pro-inflammatory cytokine interleukin-12 (IL-12), with potential + immunomodulating and antineoplastic activities. Upon administration of the Flt3 + ligand/anti-CTLA-4 antibody/IL-12 engineered oncolytic VV RIVAL-01, the virus + preferentially targets, infects and replicates in tumor cells, causing oncolysis. + In turn, the lysed tumor cells release various tumor-associated antigens (TAAs), + which induce an immune response against the tumor cells. In addition, the Flt3 + ligand, the anti-ctla-4 antibody and IL-12 are expressed by the VV in the cancer + cells and may activate the immune system within the tumor microenvironment (TME), + thereby stimulating both innate and adaptive immune responses. The anti-CTLA-4 + antibody targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated + downregulation of T-cell activation, which promotes T-cell activation. Flt3 + ligand binds to the Flt3 tyrosine kinase receptor and promotes Flt3 signaling + which plays an important role in expanding the population of antigen-presenting + dendritic cells (DCs). IL-12 activates natural killer cells (NKs), induces the + secretion of interferon-gamma and promotes CD8 cytotoxic T-cell responses against + tumor cells, which may result in immune-mediated tumor cell death and inhibition + of tumor cell proliferation. + termDef: + term: >- + Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic Vaccinia Virus + RIVAL-01 + source: NCIt + cde_id: C174049 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174049" + term_id: C174049 + term_version: 20.10d + +flt3fgfr_dual_kinase_inhibitor_max40279: + common: + description: >- + An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) + and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic + activity. Upon oral administration of FLT3/FGFR dual kinase inhibitor MAX-40279, + this agent binds to and inhibits both FGFR and FLT3, including FLT3 mutant forms, + which results in the inhibition of FGFR/FLT3-mediated signal transduction pathways. + This inhibits proliferation in FGFR/FLT3-overexpressing tumor cells. FGFR, a + family of receptor tyrosine kinases, is upregulated in many tumor cell types. + FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated + in most B-lineage neoplasms and in acute myeloid leukemias. They both play key + roles in cellular proliferation and survival. + termDef: + term: >- + FLT3/FGFR Dual Kinase Inhibitor MAX-40279 + source: NCIt + cde_id: C174517 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174517" + term_id: C174517 + term_version: 20.10d + +flt3kitcsf1r_inhibitor_nms03592088: + common: + description: >- + An orally bioavailable inhibitor of the receptor tyrosine kinases FMS-like tyrosine + kinase 3 (FLT3; CD135; STK1; FLK2), the mast/stem cell factor receptor c-Kit + (SCFR; KIT) and colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; + CD115; M-CSFR), with potential antineoplastic and immunomodulating activities + Upon administration, FLT3/KIT/CSF1R inhibitor NMS-03592088 binds to and inhibits + the activity of FLT3, KIT and CSF1R. This prevents FLT3, KIT and CSF1R-mediated + signaling and results in the inhibition of proliferation in tumor cells overexpressing + FLT3, KIT and CSF1R. In addition, NMS-03592088 binds to CSF1R expressed on monocytes, + macrophages, and osteoclasts and inhibits the binding of the CSF1R ligands colony-stimulating + factor-1 (CSF-1) and interleukin-34 (IL-34), to CSF1R. This prevents CSF1R activation + and CSF1R-mediated signaling in these cells. This blocks the production of inflammatory + mediators by macrophages and monocytes and reduces inflammation. By blocking + the recruitment to the tumor microenvironment and activity of CSF1R-dependent + tumor-associated macrophages (TAMs), NMS-03592088 inhibits the immunomodulating + activity by macrophages and enhances T-cell infiltration and antitumor T-cell + immune responses, which inhibits the proliferation of tumor cells. FLT3, a class + III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B lineage + neoplasms and in acute myeloid leukemia (AML), and plays a key role in tumor + cell proliferation. c-Kit, a transmembrane protein and receptor tyrosine kinase, + is overexpressed in solid tumors and hematological malignancies; it plays a + key role in the regulation of cell differentiation and proliferation. CSF1R, + also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 + (cluster of differentiation 115), is a cell-surface receptor for its ligand + colony stimulating factor 1 (CSF1) and plays major roles in tumor cell proliferation + and metastasis. + termDef: + term: >- + FLT3/KIT/CSF1R Inhibitor NMS-03592088 + source: NCIt + cde_id: C172195 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172195" + term_id: C172195 + term_version: 20.10d + +flt4: + common: + description: >- + This gene plays an essential role in the development of embryonic cardiovasculature + and lymphatic vessel formation. + termDef: + term: >- + FLT4 Gene + source: NCIt + cde_id: C24400 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24400" + term_id: C24400 + term_version: 20.10d + +fluorine_f_18_arag: + common: + description: >- + A radioconjugate composed of the guanosine analog arabinosyl guanine (Ara-G), + a high-affinity substrate for both cytoplasmic deoxycytidine kinase (DCK) and + mitochondrial deoxyguanosine kinase (dGK), labeled with fluorine F 18, that + can potentially be used as a tracer for imaging of activated T-lymphocytes during + positron emission tomography (PET). Upon administration, fluorine F 18 ara-G + is taken up by and accumulates in activated T-lymphocytes with high levels of + DCK and dGK. After phosphorylation by DCK and dGK, the 18F moiety can be visualized + by PET imaging. Fluorine F 18 ara-G can potentially be used as an imaging agent + to detect anti-tumor immune responses and to predict the therapeutic efficacy + of immunotherapies. DCK and dGK, both nucleoside salvage pathway enzymes, are + overexpressed in activated T-cells. + termDef: + term: >- + Fluorine F 18 Ara-G + source: NCIt + cde_id: C120100 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C120100" + term_id: C120100 + term_version: 20.10d + +fnbp1: + common: + description: >- + This gene plays a role in endocytosis. + termDef: + term: >- + FNBP1 Gene + source: NCIt + cde_id: C97540 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97540" + term_id: C97540 + term_version: 20.10d + +focal: + common: + description: >- + Limited to a specific area. + termDef: + term: >- + Focal + source: NCIt + cde_id: C28224 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28224" + term_id: C28224 + term_version: 20.05a + +follicular_adenocarcinoma_nos: + common: + description: >- + A differentiated adenocarcinoma arising from the follicular cells of the thyroid + gland. The nuclear features which characterize the thyroid gland papillary + carcinoma are absent. Radiation exposure is a risk factor and it comprises + approximately 10% to 15% of thyroid cancers. Clinically, it usually presents + as a solitary mass in the thyroid gland. It is generally unifocal and thickly + encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures + include thyroid ultrasound and fine needle biopsy. + termDef: + term: >- + Thyroid Gland Follicular Carcinoma + source: NCIt + cde_id: C8054 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8054" + term_id: C8054 + term_version: 20.05a + +follicular_adenocarcinoma_well_differentiated: + common: + description: >- + A differentiated adenocarcinoma arising from the follicular cells of the thyroid + gland. The nuclear features which characterize the thyroid gland papillary + carcinoma are absent. Radiation exposure is a risk factor and it comprises + approximately 10% to 15% of thyroid cancers. Clinically, it usually presents + as a solitary mass in the thyroid gland. It is generally unifocal and thickly + encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures + include thyroid ultrasound and fine needle biopsy. + termDef: + term: >- + Thyroid Gland Follicular Carcinoma + source: NCIt + cde_id: C8054 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8054" + term_id: C8054 + term_version: 20.05a + +follicular_adenoma: + common: + description: >- + A benign, encapsulated tumor, arising from the follicular cells of the thyroid + gland. It may be associated with thyroid hormone secretion but it does not have + malignant characteristics. + termDef: + term: >- + Thyroid Gland Follicular Adenoma + source: NCIt + cde_id: C3502 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3502" + term_id: C3502 + term_version: 20.05a + +follicular_adenoma_oxyphilic_cell: + common: + description: >- + A benign neoplasm composed of large cells with abundant eosinophilic granular + cytoplasm. Representative examples include oncocytic adenomas of the thyroid + gland, parathyroid gland, and pituitary gland. + termDef: + term: >- + Oncocytic Adenoma + source: NCIt + cde_id: C3759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3759" + term_id: C3759 + term_version: 20.05a + +follicular_carcinoma_nos: + common: + description: >- + A differentiated adenocarcinoma arising from the follicular cells of the thyroid + gland. The nuclear features which characterize the thyroid gland papillary + carcinoma are absent. Radiation exposure is a risk factor and it comprises + approximately 10% to 15% of thyroid cancers. Clinically, it usually presents + as a solitary mass in the thyroid gland. It is generally unifocal and thickly + encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures + include thyroid ultrasound and fine needle biopsy. + termDef: + term: >- + Thyroid Gland Follicular Carcinoma + source: NCIt + cde_id: C8054 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8054" + term_id: C8054 + term_version: 20.05a + +follicular_carcinoma_oxyphilic_cell: + common: + description: >- + An adenocarcinoma characterized by the presence of large malignant epithelial + cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative + examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast + carcinoma, and salivary gland oncocytic carcinoma. + termDef: + term: >- + Oxyphilic Adenocarcinoma + source: NCIt + cde_id: C3679 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3679" + term_id: C3679 + term_version: 20.05a + +follicular_carcinoma_well_differentiated: + common: + description: >- + A differentiated adenocarcinoma arising from the follicular cells of the thyroid + gland. The nuclear features which characterize the thyroid gland papillary + carcinoma are absent. Radiation exposure is a risk factor and it comprises + approximately 10% to 15% of thyroid cancers. Clinically, it usually presents + as a solitary mass in the thyroid gland. It is generally unifocal and thickly + encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures + include thyroid ultrasound and fine needle biopsy. + termDef: + term: >- + Thyroid Gland Follicular Carcinoma + source: NCIt + cde_id: C8054 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8054" + term_id: C8054 + term_version: 20.05a + +follicular_dendritic_cell_sarcoma: + common: + description: >- + A neoplasm composed of spindle to ovoid cells which have morphologic and immunophenotypic + characteristics of follicular dendritic cells. It affects lymph nodes and other + sites including the tonsils, gastrointestinal tract, spleen, liver, soft tissues, + skin, and oral cavity. It usually behaves as a low grade sarcoma. Treatment + options include complete surgical removal of the tumor with or without adjuvant + chemotherapy or radiotherapy. Recurrences have been reported in up to half of + the cases. + termDef: + term: >- + Follicular Dendritic Cell Sarcoma + source: NCIt + cde_id: C9281 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9281" + term_id: C9281 + term_version: 20.05a + +follicular_dendritic_cell_tumor: + common: + description: >- + A neoplasm composed of spindle to ovoid cells which have morphologic and immunophenotypic + characteristics of follicular dendritic cells. It affects lymph nodes and other + sites including the tonsils, gastrointestinal tract, spleen, liver, soft tissues, + skin, and oral cavity. It usually behaves as a low grade sarcoma. Treatment + options include complete surgical removal of the tumor with or without adjuvant + chemotherapy or radiotherapy. Recurrences have been reported in up to half of + the cases. + termDef: + term: >- + Follicular Dendritic Cell Sarcoma + source: NCIt + cde_id: C9281 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9281" + term_id: C9281 + term_version: 20.05a + +follicular_fibroma: + common: + description: >- + A rare, pilar-associated mesenchyme neoplasm with follicular differentiation. + It usually occurs in the face, neck, and chest. It presents as a dome-shaped + papular lesion. It is composed of epithelial and mesenchymal cells. Patients + with Birt-Hogg-Dube syndrome may develop follicular fibromas. + termDef: + term: >- + Fibrofolliculoma + source: NCIt + cde_id: C43331 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43331" + term_id: C43331 + term_version: 20.05a + +follicular_lymphoma_grade_1: + common: + description: >- + A follicular lymphoma which contains up to 5 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 1 Follicular Lymphoma + source: NCIt + cde_id: C3465 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3465" + term_id: C3465 + term_version: 20.05a + +follicular_lymphoma_grade_2: + common: + description: >- + A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic + field. + termDef: + term: >- + Grade 2 Follicular Lymphoma + source: NCIt + cde_id: C8968 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8968" + term_id: C8968 + term_version: 20.05a + +follicular_lymphoma_grade_3: + common: + description: >- + A follicular lymphoma which contains more than 15 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 3 Follicular Lymphoma + source: NCIt + cde_id: C3460 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3460" + term_id: C3460 + term_version: 20.05a + +follicular_lymphoma_grade_3a: + common: + description: >- + A grade 3 follicular lymphoma in which centrocytes are present. + termDef: + term: >- + Grade 3a Follicular Lymphoma + source: NCIt + cde_id: C7191 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7191" + term_id: C7191 + term_version: 20.05a + +follicular_lymphoma_grade_3b: + common: + description: >- + A grade 3 follicular lymphoma composed of solid sheets of centroblasts. + termDef: + term: >- + Grade 3b Follicular Lymphoma + source: NCIt + cde_id: C7192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7192" + term_id: C7192 + term_version: 20.05a + +follicular_lymphoma_nos: + common: + description: >- + A neoplasm of follicle centre B cells which has at least a partial follicular + pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas + in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, + follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending + on the percentage of the large lymphocytes present. The vast majority of cases + (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates + with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade + 3 is more aggressive (adapted from WHO, 2001). + termDef: + term: >- + Follicular Lymphoma + source: NCIt + cde_id: C3209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3209" + term_id: C3209 + term_version: 20.05a + +follicular_lymphoma_small_cleaved_cell: + common: + description: >- + A follicular lymphoma which contains up to 5 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 1 Follicular Lymphoma + source: NCIt + cde_id: C3465 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3465" + term_id: C3465 + term_version: 20.05a + +follicular_thyroid_carcinoma_ftc_encapsulated_angioinvasive: + common: + description: >- + An encapsulated follicular carcinoma of the thyroid gland which shows angioinvasion. + termDef: + term: >- + Thyroid Gland Follicular Carcinoma, Encapsulated Angioinvasive + source: NCIt + cde_id: C156122 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156122" + term_id: C156122 + term_version: 20.05a + +foritinib_succinate: + common: + description: >- + The succinate salt form of foritinib, an orally bioavailable inhibitor of the + receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and C-ros oncogene + 1 (ROS1), with potential antineoplastic activity. Upon oral administration, + foritinib targets, binds to and inhibits the activity of ALK and ROS1, which + leads to the disruption of ALK- and ROS1-mediated signaling and the inhibition + of cell growth in ALK- and ROS1-expressing tumor cells. In addition, foritinib + is able to cross the blood brain barrier. ALK and ROS1, overexpressed or mutated + in many tumor cell types, play key roles in tumor cell proliferation, survival, + invasion and metastasis. + termDef: + term: >- + Foritinib Succinate + source: NCIt + cde_id: C175475 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175475" + term_id: C175475 + term_version: 20.10d + +fosgemcitabine_palabenamide: + common: + description: >- + A pyrimidine analogue and a proprietary prodrug based on an aryloxy phosphoramidate + derivative of gemcitabine with potential antineoplastic activity. Upon intravenous + administration and cellular uptake, fosgemcitabine palabenamide is converted + into the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, + dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide + pool available for DNA replication; dFdCTP is incorporated into DNA, resulting + in premature termination of DNA replication and eventually induction of apoptosis. + With the phosphoramidate moiety on the gemcitabine monophosphate group, NUC-1031 + has improved properties over its parent molecule: 1) is more lipophilic and + accumulates in cancer cells by passive diffusion and does not require a nucleoside + transporter, 2) as the agent is delivered in the monophosphate form, the first + phosphorylation step by deoxycytidine kinase is not required, 3) this agent + is not susceptible to deactivation by cytidine deaminase cleavage of the monophosphorylated + form. Altogether, this may help overcome resistance to gemcitabine. + termDef: + term: >- + Fosgemcitabine Palabenamide + source: NCIt + cde_id: C102752 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102752" + term_id: C102752 + term_version: 20.10d + +fosifloxuridine_nafalbenamide: + common: + description: >- + A phosphoramidate-based prodrug of the monophosphate (MP) form of 5-fluoro-2'-deoxyuridine + (FUdR; FUDR), the active metabolite of fluorouracil (5-FU), an antimetabolite + fluoropyrimidine analog of the pyrimidine nucleoside, with potential antineoplastic + activity. Upon administration of the nucleotide analog prodrug fosifloxuridine + nafalbenamide, fosifloxuridine nafalbenamide is readily taken up by tumor cells. + In the tumor cell, the phosphoramidate moiety is removed and fosifloxuridine + nafalbenamide is converted to its active form FUDR-MP. In turn, FUDR-MP binds + to and inhibits thymidylate synthase (TS), resulting in the depletion of thymidine + triphosphate (TTP) and thus DNA synthesis. With the phosphoramidate moiety attached + to FUDR-MP, fosifloxuridine nafalbenamide, compared to 5-FU, is more lipophilic + and accumulates in cancer cells by passive diffusion and does not require a + nucleoside transporter, thereby generating higher intracellular concentrations. + In addition, compared to 5-FU, once inside the cell FUDR-MP does not need to + be phosphorylated and is already in its active form. Unlike 5-FU, fosifloxuridine + nafalbenamide does not get deactivated or converted into toxic metabolites by + dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP), which + leads to both a longer half-life and less toxicity. + termDef: + term: >- + Fosifloxuridine Nafalbenamide + source: NCIt + cde_id: C156680 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156680" + term_id: C156680 + term_version: 20.10d + +foster_brother: + common: + description: >- + A male child being fostered by your parents or legal guardians. + termDef: + term: >- + Foster Brother + source: NCIt + cde_id: C165788 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165788" + term_id: C165788 + term_version: 19.12e + +foster_daughter: + common: + description: >- + A female child you are fostering. + termDef: + term: >- + Foster Daughter + source: NCIt + cde_id: C165790 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165790" + term_id: C165790 + term_version: 19.12e + +foster_father: + common: + description: >- + A male foster parent. + termDef: + term: >- + Foster Father + source: NCIt + cde_id: C165792 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165792" + term_id: C165792 + term_version: 19.12e + +foster_mother: + common: + description: >- + A female foster parent. + termDef: + term: >- + Foster Mother + source: NCIt + cde_id: C165793 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165793" + term_id: C165793 + term_version: 19.12e + +foster_sister: + common: + description: >- + A female child being fostered by your parents or legal guardians. + termDef: + term: >- + Foster Sister + source: NCIt + cde_id: C165794 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165794" + term_id: C165794 + term_version: 19.12e + +foster_son: + common: + description: >- + A male child you are fostering. + termDef: + term: >- + Foster Son + source: NCIt + cde_id: C165795 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165795" + term_id: C165795 + term_version: 19.12e + +foxa1: + common: + description: >- + This gene plays a role in the modulation of gene expression. + termDef: + term: >- + FOXA1 Gene + source: NCIt + cde_id: C101646 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101646" + term_id: C101646 + term_version: 20.10d + +foxl2: + common: + description: >- + This gene plays a role in ovarian function. + termDef: + term: >- + FOXL2 Gene + source: NCIt + cde_id: C75472 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75472" + term_id: C75472 + term_version: 20.10d + +foxo1: + common: + description: >- + This gene is involved in transcriptional regulation and may play a role in myogenic + growth and differentiation. + termDef: + term: >- + FOXO1 Gene + source: NCIt + cde_id: C24402 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24402" + term_id: C24402 + term_version: 20.10d + +foxo3: + common: + description: >- + This gene is involved in transcriptional regulation and apoptosis. + termDef: + term: >- + FOXO3 Gene + source: NCIt + cde_id: C28519 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28519" + term_id: C28519 + term_version: 20.10d + +foxo4: + common: + description: >- + This gene plays a role in smooth muscle cell differentiation, cellular growth, + cell cycle regulation and tumor suppression. + termDef: + term: >- + FOXO4 Gene + source: NCIt + cde_id: C24606 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24606" + term_id: C24606 + term_version: 20.10d + +foxp1: + common: + description: >- + This gene is involved in transcriptional modulation. + termDef: + term: >- + FOXP1 Gene + source: NCIt + cde_id: C97549 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97549" + term_id: C97549 + term_version: 20.10d + +foxr1: + common: + description: >- + This gene plays a role in DNA binding and transcriptional regulation. + termDef: + term: >- + FOXR1 Gene + source: NCIt + cde_id: C143124 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143124" + term_id: C143124 + term_version: 20.10d + +frameshift_variant: + common: + description: >- + A mutation occurring within the protein-coding region of a gene which results + in a shift in the reading frame of the encoded protein. Frameshift mutations + often result in the premature truncation of a gene product. + termDef: + term: >- + Frameshift Mutation + source: NCIt + cde_id: C17354 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17354" + term_id: C17354 + term_version: 20.10d + +france: + common: + description: >- + A country in western Europe, bordering the Bay of Biscay and the English Channel, + between Germany and Spain. + termDef: + term: >- + France + source: NCIt + cde_id: C16592 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16592" + term_id: C16592 + term_version: 19.12e + +franklin_disease: + common: + description: >- + A clonal disorder characterized by the secretion of a truncated gamma chain. In + most cases, it is associated with morphologic changes also seen in lymphoplasmacytic + lymphomas, but the clinical course is typically more aggressive than in lymphoplasmacytic + lymphoma. + termDef: + term: >- + Gamma Heavy Chain Disease + source: NCIt + cde_id: C3083 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3083" + term_id: C3083 + term_version: 20.05a + +fraternal_twin_brother: + common: + description: >- + A male full sibling that developed from a separately fertilized ova during the + same pregnancy. + termDef: + term: >- + Fraternal Twin Brother + source: NCIt + cde_id: C165796 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165796" + term_id: C165796 + term_version: 19.12e + +fraternal_twin_sibling: + common: + description: >- + Either of the two offspring from separately fertilized ova during the same pregnancy. + termDef: + term: >- + Fraternal Twin + source: NCIt + cde_id: C73428 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73428" + term_id: C73428 + term_version: 19.12e + +fraternal_twin_sister: + common: + description: >- + A female full sibling that developed from a separately fertilized ova during + the same pregnancy. + termDef: + term: >- + Fraternal Twin Sister + source: NCIt + cde_id: C165797 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165797" + term_id: C165797 + term_version: 19.12e + +french_guiana: + common: + description: >- + A country in northern South America, bordering the North Atlantic Ocean, between + Brazil and Suriname. + termDef: + term: >- + French Guiana + source: NCIt + cde_id: C16593 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16593" + term_id: C16593 + term_version: 19.12e + +french_polynesia: + common: + description: >- + An archipelago in the South Pacific Ocean, east of the Cook Islands. + termDef: + term: >- + French Polynesia + source: NCIt + cde_id: C16594 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16594" + term_id: C16594 + term_version: 19.12e + +frontal_lobe: + common: + description: >- + The part of the brain located anterior to the parietal lobes at the front of + each cerebral hemisphere. + termDef: + term: >- + Frontal Lobe + source: NCIt + cde_id: C12352 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12352" + term_id: C12352 + term_version: 20.05a + +frontal_sinus: + common: + description: >- + The paired, mucosal lined air spaces located above the orbit and communicating + with the nasal passages. + termDef: + term: >- + Frontal Sinus + source: NCIt + cde_id: C12277 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12277" + term_id: C12277 + term_version: 20.05a + +fstl3: + common: + description: >- + This gene plays a role in a variety of processes including transcription. + termDef: + term: >- + FSTL3 Gene + source: NCIt + cde_id: C24408 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24408" + term_id: C24408 + term_version: 20.10d + +fubp1: + common: + description: >- + This gene plays a role in transcriptional modulation. + termDef: + term: >- + FUBP1 Gene + source: NCIt + cde_id: C99614 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99614" + term_id: C99614 + term_version: 20.10d + +full_brother: + common: + description: >- + A male who shares with his sibling the genetic makeup inherited from both of + the biological parents. + termDef: + term: >- + Full Brother + source: NCIt + cde_id: C111201 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111201" + term_id: C111201 + term_version: 19.12e + +full_sister: + common: + description: >- + A female who shares with her sibling the genetic makeup inherited from both + of the biological parents. + termDef: + term: >- + Full Sister + source: NCIt + cde_id: C111202 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111202" + term_id: C111202 + term_version: 19.12e + +fundus_of_stomach: + common: + description: >- + The portion of the stomach that lies above the cardiac notch. It allows for + the accumulation of gases produced by chemical digestion. + termDef: + term: >- + Fundus of the Stomach + source: NCIt + cde_id: C12257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12257" + term_id: C12257 + term_version: 20.05a + +fundus_uteri: + common: + description: >- + The upper, rounded portion of the uterus which is opposite from the cervix. + termDef: + term: >- + Fundus Uteri + source: NCIt + cde_id: C12315 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12315" + term_id: C12315 + term_version: 20.05a + +furnace_or_boiler_smoke: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates emitted by a boiler or furnace. + termDef: + term: >- + Furnace or Boiler Smoke Exposure + source: NCIt + cde_id: C164083 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164083" + term_id: C164083 + term_version: 19.12e + +fus: + common: + description: >- + This gene is involved in gene expression, genomic integrity and RNA processing. + termDef: + term: >- + FUS Gene + source: NCIt + cde_id: C91852 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C91852" + term_id: C91852 + term_version: 20.10d + +futibatinib: + common: + description: >- + An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) + with potential antineoplastic activity. Futibatinib selectively and irreversibly + binds to and inhibits FGFR, which may result in the inhibition of both the FGFR-mediated + signal transduction pathway and tumor cell proliferation, and increased cell + death in FGFR-overexpressing tumor cells. FGFR is a receptor tyrosine kinase + essential to tumor cell proliferation, differentiation and survival and its + expression is upregulated in many tumor cell types. + termDef: + term: >- + Futibatinib + source: NCIt + cde_id: C114283 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C114283" + term_id: C114283 + term_version: 20.10d + +g_cell_tumor_malignant: + common: + description: >- + A gastrin-producing neuroendocrine tumor. It is characterized by inappropriate + secretion of gastrin and associated with Zollinger Ellison syndrome. It displays + vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Gastrinoma + source: NCIt + cde_id: C65188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65188" + term_id: C65188 + term_version: 20.05a + +g_cell_tumor_nos: + common: + description: >- + A gastrin-producing neuroendocrine tumor. It is usually located in the pancreas + but it is also found at other anatomic sites, including the stomach and small + intestine. + termDef: + term: >- + Gastrin-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C3050 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3050" + term_id: C3050 + term_version: 20.05a + +g_proteincoupled_estrogen_receptor_agonist_lns8801: + common: + description: >- + An orally bioavailable selective agonist of the G protein-coupled estrogen receptor + (G protein-coupled estrogen receptor 1; GPER; GPER1; GPR30), with potential + immunomodulating and antineoplastic activities. Upon oral administration, LNS8801 + targets, binds to and activates GPER. This activates GPER-mediated signaling + and suppresses the expression of various tumor-associated genes, such as c-Myc + and programmed cell death-ligand 1 (PD-L1). This leads to an inhibition of tumor + cell proliferation. GPER activation may also induce immune memory. GPER is a + membrane protein and a member of the G-protein coupled receptors (GPCRs) that + are widely distributed in various tissues. GPER is a tumor suppressor in a wide + range of cell cancer types. + termDef: + term: >- + G Protein-coupled Estrogen Receptor Agonist LNS8801 + source: NCIt + cde_id: C165626 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165626" + term_id: C165626 + term_version: 20.10d + +g1: + common: + description: >- + A morphologic qualifier indicating that a cancerous lesion is well differentiated. + termDef: + term: >- + Grade 1 + source: NCIt + cde_id: C28077 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28077" + term_id: C28077 + term_version: 20.05a + +g2: + common: + description: >- + A morphologic qualifier indicating that a cancerous lesion is moderately differentiated. + termDef: + term: >- + Grade 2 + source: NCIt + cde_id: C28078 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28078" + term_id: C28078 + term_version: 20.05a + +g3: + common: + description: >- + A morphologic qualifier indicating that a cancerous lesion is poorly differentiated. + termDef: + term: >- + Grade 3 + source: NCIt + cde_id: C28079 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28079" + term_id: C28079 + term_version: 20.05a + +g4: + common: + description: >- + A morphologic qualifier indicating that a cancerous lesion is undifferentiated. + termDef: + term: >- + Grade 4 + source: NCIt + cde_id: C28082 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28082" + term_id: C28082 + term_version: 20.05a + +gabon: + common: + description: >- + A country in central Africa, bordering the Atlantic Ocean at the Equator, between + Republic of the Congo and Equatorial Guinea. + termDef: + term: >- + Gabon + source: NCIt + cde_id: C16596 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16596" + term_id: C16596 + term_version: 19.12e + +gain: + common: + description: >- + Gain; to increase or the amount of increase. + termDef: + term: >- + Gain + source: NCIt + cde_id: C37956 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C37956" + term_id: C37956 + term_version: 20.10d + +gallbladder: + common: + description: >- + A pear-shaped organ located under the liver that stores and concentrates bile + secreted by the liver. From the gallbladder the bile is delivered through the + bile ducts into the intestine thereby aiding the digestion of fat-containing + foods. + termDef: + term: >- + Gallbladder + source: NCIt + cde_id: C12377 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12377" + term_id: C12377 + term_version: 20.05a + +gallbladder_cancer: + common: + description: >- + A malignant tumor arising from the epithelium of the gallbladder. It is usually + associated with the presence of gallstones. Clinical symptoms are not specific + and usually present late in the course. Morphologically, most gallbladder carcinomas + are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet + ring carcinomas, and undifferentiated carcinomas can also occur. + termDef: + term: >- + Gallbladder Carcinoma + source: NCIt + cde_id: C3844 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3844" + term_id: C3844 + term_version: 19.12e + +galliumbased_bone_resorption_inhibitor_ap002: + common: + description: >- + An orally bioavailable gallium (Ga)-based small molecule agent with potential + anti-bone resorption and antineoplastic activities. Upon oral administration, + AP-002 selectively inhibits osteoclast differentiation and bone resorption, + and may promote the growth of osteoblasts thereby improving the skeletal sequelae + of bony metastases which include pain, spinal cord compression, fractures and + hypercalcemia of malignancy. Additionally, AP-002 may, through an as of yet + undescribed mechanism of action, directly target and kill bone tumor cells. + termDef: + term: >- + Gallium-based Bone Resorption Inhibitor AP-002 + source: NCIt + cde_id: C165650 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165650" + term_id: C165650 + term_version: 20.10d + +gambia: + common: + description: >- + A country in western Africa, bordering the North Atlantic Ocean and surrounded + by Senegal. + termDef: + term: >- + Gambia + source: NCIt + cde_id: C16598 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16598" + term_id: C16598 + term_version: 19.12e + +gamma_heavy_chain_disease: + common: + description: >- + A clonal disorder characterized by the secretion of a truncated gamma chain. In + most cases, it is associated with morphologic changes also seen in lymphoplasmacytic + lymphomas, but the clinical course is typically more aggressive than in lymphoplasmacytic + lymphoma. + termDef: + term: >- + Gamma Heavy Chain Disease + source: NCIt + cde_id: C3083 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3083" + term_id: C3083 + term_version: 20.05a + +gammaenolase: + common: + description: >- + The determination of the amount of neuron specific enolase present in a sample. + termDef: + term: >- + Neuron Specific Enolase Measurement + source: NCIt + cde_id: C116205 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116205" + term_id: C116205 + term_version: 20.10d + +gangliocytic_paraganglioma: + common: + description: >- + A benign or malignant neoplasm arising from paraganglia located along the sympathetic + or parasympathetic nerves. Infrequently, it may arise outside the usual distribution + of the sympathetic and parasympathetic paraganglia. Tumors arising from the + adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas + usually display a nesting (Zellballen) growth pattern. There are no reliable + morphologic criteria to distinguish between benign and malignant paragangliomas. The + only definitive indicator of malignancy is the presence of regional or distant + metastases. + termDef: + term: >- + Paraganglioma + source: NCIt + cde_id: C3308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3308" + term_id: C3308 + term_version: 20.05a + +gangliocytoma: + common: + description: >- + A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, + mature ganglion cells. + termDef: + term: >- + Gangliocytoma + source: NCIt + cde_id: C6934 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6934" + term_id: C6934 + term_version: 20.05a + +ganglioglioma_anaplastic: + common: + description: >- + A WHO grade III neuroepithelial neoplasm composed of neoplastic, mature ganglion + cells and anaplastic glial cells. The anaplastic changes in the glial component + and high MIB-1 and TP53 labeling indices may indicate aggressive behavior. However, + the correlation of histological anaplasia with clinical outcome is inconsistent. + (Adapted from WHO) + termDef: + term: >- + Anaplastic Ganglioglioma + source: NCIt + cde_id: C4717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4717" + term_id: C4717 + term_version: 20.05a + +ganglioglioma_nos: + common: + description: >- + A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, + mature ganglion cells and neoplastic glial cells. Some gangliogliomas show anaplastic + features in their glial component and are considered to be WHO grade III. Rare + cases of newly diagnosed gangliogliomas with grade IV (glioblastoma) changes + in the glial component have also been reported. (Adapted from WHO) + termDef: + term: >- + Ganglioglioma + source: NCIt + cde_id: C3788 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3788" + term_id: C3788 + term_version: 20.05a + +ganglioneuroblastoma: + common: + description: >- + A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion + cells, and a stroma with Schwannian differentiation constituting more than fifty-percent + of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, + intermixed and ganglioneuroblastoma, nodular. + termDef: + term: >- + Ganglioneuroblastoma + source: NCIt + cde_id: C3790 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3790" + term_id: C3790 + term_version: 20.05a + +ganglioneuroma: + common: + description: >- + A benign neuroblastic tumor of the sympathetic nervous system that occurs in + childhood. Ganglioneuroma typically arises from the sympathetic trunk in the + mediastinum. Histologic features include spindle cell proliferation (resembling + a neurofibroma) and the presence of large ganglion cells. Common presenting + features include a palpable abdominal mass, hepatomegaly, and a thoracic mass + detected on routine chest X-ray. + termDef: + term: >- + Ganglioneuroma + source: NCIt + cde_id: C3049 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3049" + term_id: C3049 + term_version: 20.05a + +ganglioneuromatosis: + common: + description: >- + Extensive and diffuse infiltration of tissues by ganglioneuroma. + termDef: + term: >- + Ganglioneuromatosis + source: NCIt + cde_id: C66804 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66804" + term_id: C66804 + term_version: 20.05a + +gant: + common: + description: >- + A variant of gastrointestinal stromal tumor with ultrastructural features of + neural differentiation. It is composed of spindle or epithelioid neoplastic + cells. + termDef: + term: >- + Gastrointestinal Autonomic Nerve Tumor + source: NCIt + cde_id: C27940 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27940" + term_id: C27940 + term_version: 20.05a + +gas_burning_smoke_propane: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced when propane is rapidly oxidized via combustion. + termDef: + term: >- + Propane Smoke Exposue + source: NCIt + cde_id: C164084 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164084" + term_id: C164084 + term_version: 19.12e + +gas7: + common: + description: >- + This gene may play a role in neuronal development. + termDef: + term: >- + GAS7 Gene + source: NCIt + cde_id: C97562 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97562" + term_id: C97562 + term_version: 20.10d + +gastric_antrum: + common: + description: >- + The initial part of the pyloric canal of the stomach. This site contains endocrine + cells that produce gastrin and somatostatin. + termDef: + term: >- + Antrum Pylori + source: NCIt + cde_id: C12259 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12259" + term_id: C12259 + term_version: 20.05a + +gastric_cancer: + common: + description: >- + A malignant epithelial tumor of the stomach mucosa. The vast majority of gastric + carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. + termDef: + term: >- + Gastric Carcinoma + source: NCIt + cde_id: C4911 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4911" + term_id: C4911 + term_version: 19.12e + +gastrin_cell_tumor: + common: + description: >- + A gastrin-producing neuroendocrine tumor. It is usually located in the pancreas + but it is also found at other anatomic sites, including the stomach and small + intestine. + termDef: + term: >- + Gastrin-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C3050 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3050" + term_id: C3050 + term_version: 20.05a + +gastrin_cell_tumor_malignant: + common: + description: >- + A gastrin-producing neuroendocrine tumor. It is characterized by inappropriate + secretion of gastrin and associated with Zollinger Ellison syndrome. It displays + vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Gastrinoma + source: NCIt + cde_id: C65188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65188" + term_id: C65188 + term_version: 20.05a + +gastrinoma_malignant: + common: + description: >- + A gastrin-producing neuroendocrine tumor. It is characterized by inappropriate + secretion of gastrin and associated with Zollinger Ellison syndrome. It displays + vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Gastrinoma + source: NCIt + cde_id: C65188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65188" + term_id: C65188 + term_version: 20.05a + +gastrinoma_nos: + common: + description: >- + A gastrin-producing neuroendocrine tumor. It is usually located in the pancreas + but it is also found at other anatomic sites, including the stomach and small + intestine. + termDef: + term: >- + Gastrin-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C3050 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3050" + term_id: C3050 + term_version: 20.05a + +gastrointestinal_autonomic_nerve_tumor: + common: + description: >- + A variant of gastrointestinal stromal tumor with ultrastructural features of + neural differentiation. It is composed of spindle or epithelioid neoplastic + cells. + termDef: + term: >- + Gastrointestinal Autonomic Nerve Tumor + source: NCIt + cde_id: C27940 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27940" + term_id: C27940 + term_version: 20.05a + +gastrointestinal_stromal_sarcoma: + common: + description: >- + High Risk Gastrointestinal Stromal Tumor + termDef: + term: >- + High Risk Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C27243 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27243" + term_id: C27243 + term_version: 20.05a + +gastrointestinal_stromal_tumor_benign: + common: + description: >- + A gastrointestinal stromal tumor that is characterized by a maximum diameter + equal or less than 5 cm (gastric localization), or equal or less than 2 cm (intestinal + localization) and no more than 5 mitotic figures per 50 high power fields. + termDef: + term: >- + Benign Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C53998 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53998" + term_id: C53998 + term_version: 20.05a + +gastrointestinal_stromal_tumor_malignant: + common: + description: >- + A gastrointestinal stromal tumor that is characterized by large size (diameter + greater than 10 cm for gastric localization and greater than 5 cm for intestinal + localization) or more than 5 mitotic figures per 50 high power fields. + termDef: + term: >- + Malignant Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C53999 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53999" + term_id: C53999 + term_version: 20.05a + +gastrointestinal_stromal_tumor_nos: + common: + description: >- + A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases + of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal + gastrointestinal stromal tumor). It is a tumor that differentiates along the + lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating + mutations. Until recently, surgery has been the only effective therapy for this + tumor. However, many patients still experience recurrence. Conventional chemotherapy + and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, + imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the + treatment of relapsed and unresectable cases. + termDef: + term: >- + Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C3868 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3868" + term_id: C3868 + term_version: 20.05a + +gastrointestinal_stromal_tumor_uncertain_malignant_potential: + common: + description: >- + A gastrointestinal stromal tumor that is characterized by a maximum diameter + greater than 5 cm and equal or less than 10 cm (gastric localization), or greater + than 2 cm and equal or less than 5 cm (intestinal localization) and no more + than 5 mitotic figures per 50 high power fields. + termDef: + term: >- + Gastrointestinal Stromal Tumor of Uncertain Malignant Potential + source: NCIt + cde_id: C54000 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54000" + term_id: C54000 + term_version: 20.05a + +gastrointestinal_tract_nos: + common: + description: >- + The upper gastrointestinal (GI) tract is comprised of mouth, pharynx, esophagus + and stomach while the lower GI tract consists of intestines and anus. The primary + function of the GI tract is to ingest, digest, absorb and ultimately excrete + food stuff. + termDef: + term: >- + Gastrointestinal Tract + source: NCIt + cde_id: C34082 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C34082" + term_id: C34082 + term_version: 20.05a + +gata1: + common: + description: >- + This gene is involved in erythropoiesis and transcriptional activation. + termDef: + term: >- + GATA1 Gene + source: NCIt + cde_id: C28575 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28575" + term_id: C28575 + term_version: 20.10d + +gata2: + common: + description: >- + This gene is involved in both DNA binding and transcriptional regulation. + termDef: + term: >- + GATA2 Gene + source: NCIt + cde_id: C97552 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97552" + term_id: C97552 + term_version: 20.10d + +gata3: + common: + description: >- + This gene plays a role in the modulation of transcription. + termDef: + term: >- + GATA3 Gene + source: NCIt + cde_id: C75492 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75492" + term_id: C75492 + term_version: 20.10d + +gb: + common: + description: >- + A morphologic qualifier indicating that a neoplasm is of borderline malignancy. + termDef: + term: >- + Grade B + source: NCIt + cde_id: C113729 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113729" + term_id: C113729 + term_version: 20.05a + +gbm_antigens_and_alloantigens_immunotherapeutic_vaccine: + common: + description: >- + An orally bioavailable, immunotherapeutic vaccine composed of hydrolyzed and + formulated glioblastoma multiforme (GBM) antigens and alloantigens derived from + a pool of patients' cancer cells in the blood and samples of tumor tissues, + with potential immunomodulating and antineoplastic activities. Upon oral administration + of the GBM antigens and alloantigens immunotherapeutic vaccine, the GBM antigens + and alloantigens may stimulate the host immune system via antigen-presenting + cells (APCs) lining the gut to mount an immune response against tumor cells + expressing these antigens. This may lead to tumor cell death. + termDef: + term: >- + GBM Antigens and Alloantigens Immunotherapeutic Vaccine + source: NCIt + cde_id: C172199 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172199" + term_id: C172199 + term_version: 20.10d + +gelatinous_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +gelatinous_carcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +gemistocytic_astrocytoma: + common: + description: >- + A rare variant of diffuse astrocytoma. It is characterized by the presence of + a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. + Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary + cytoplasm which appears to displace the dark, angulated nucleus to the periphery + of the cell. To make the diagnosis of gemistocytic astrocytoma, gemistocytes + should amount to more than approximately 20% of all tumor cells. (Adapted from + WHO) + termDef: + term: >- + Gemistocytic Astrocytoma + source: NCIt + cde_id: C4321 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4321" + term_id: C4321 + term_version: 20.05a + +gemistocytoma: + common: + description: >- + A rare variant of diffuse astrocytoma. It is characterized by the presence of + a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. + Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary + cytoplasm which appears to displace the dark, angulated nucleus to the periphery + of the cell. To make the diagnosis of gemistocytic astrocytoma, gemistocytes + should amount to more than approximately 20% of all tumor cells. (Adapted from + WHO) + termDef: + term: >- + Gemistocytic Astrocytoma + source: NCIt + cde_id: C4321 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4321" + term_id: C4321 + term_version: 20.05a + +genetically_modified_interleukin12_transgeneencoding_bifidobacterium_longum: + common: + description: >- + A live, genetically modified probiotic bacteria Bifidobacterium longum (B. longum) + engineered to deliver genetic material encoding the human pro-inflammatory transgene + interleukin-12 (IL-12), with potential immunoactivating activity. Upon administration + of genetically modified IL-12 transgene-encoding B. longum, the bacteria selectively + colonize hypoxic tumor tissues and deliver plasmid DNA encoding the IL-12 transgene + within the tumor microenvironment (TME). IL-12 is translated in cells and activates + the immune system by promoting the activation of natural killer cells (NK cells), + inducing secretion of interferon-gamma and promoting cytotoxic T-cell responses + against tumor cells. This may result in both immune-mediated tumor cell death + and the inhibition of tumor cell proliferation. + termDef: + term: >- + Genetically Modified Interleukin-12 Transgene-encoding Bifidobacterium longum + source: NCIt + cde_id: C171371 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171371" + term_id: C171371 + term_version: 20.10d + +genital_rhabdomyoma: + common: + description: >- + A rare benign skeletal muscle neoplasm arising from the female genital tract. + It is characterized by the presence of small nucleated rhabdomyoblasts within + a fibrous and myxoid stroma. + termDef: + term: >- + Genital Rhabdomyoma + source: NCIt + cde_id: C6517 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6517" + term_id: C6517 + term_version: 20.05a + +georgia: + common: + description: >- + A country in southwestern Asia, bordering the Black Sea, between Turkey and + Russia. + termDef: + term: >- + Georgia + source: NCIt + cde_id: C16634 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16634" + term_id: C16634 + term_version: 19.12e + +germ_cell_tumor_nonseminomatous: + common: + description: >- + A term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, + or mixed forms of these tumors. + termDef: + term: >- + Nongerminomatous Germ Cell Tumor + source: NCIt + cde_id: C121619 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121619" + term_id: C121619 + term_version: 20.05a + +germ_cell_tumor_nos: + common: + description: >- + A benign or malignant, gonadal or extragonadal neoplasm that originates from + germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, + and yolk sac tumor. + termDef: + term: >- + Germ Cell Tumor + source: NCIt + cde_id: C3708 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3708" + term_id: C3708 + term_version: 20.05a + +germ_cell_tumors_with_associated_hematological_malignancy: + common: + description: >- + An extragonadal non-seminomatous malignant germ cell tumor that arises from + the mediastinum and is associated with a hematologic malignancy. The hematologic + malignancies are clonally related to the malignant germ cell tumor and include + acute leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, and + mastocytosis. + termDef: + term: >- + Malignant Mediastinal Germ Cell Tumor with Associated Hematologic Malignancy + source: NCIt + cde_id: C45733 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45733" + term_id: C45733 + term_version: 20.05a + +germany: + common: + description: >- + A country in central Europe, bordering the Baltic Sea and the North Sea, between + the Netherlands and Poland, south of Denmark. + termDef: + term: >- + Germany + source: NCIt + cde_id: C16636 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16636" + term_id: C16636 + term_version: 19.12e + +germinoma: + common: + description: >- + A malignant germ cell tumor arising in the central nervous system. It is characterized + by the presence of primitive, large malignant germ cells and lymphocytes. + termDef: + term: >- + Germinoma + source: NCIt + cde_id: C3753 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3753" + term_id: C3753 + term_version: 20.05a + +germline: + common: + description: >- + Any mutation that appears in the gametes and which will therefore be transmitted + to the progeny with some frequency. + termDef: + term: >- + Germline Mutation + source: NCIt + cde_id: C17666 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17666" + term_id: C17666 + term_version: 20.10d + +ghana: + common: + description: >- + A country in western Africa, bordering the Gulf of Guinea, between Cote d'Ivoire + and Togo. + termDef: + term: >- + Ghana + source: NCIt + cde_id: C26330 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26330" + term_id: C26330 + term_version: 19.12e + +ghost_cell_odontogenic_carcinoma: + common: + description: >- + A carcinoma usually arising from the maxilla and less often the mandible. Symptoms + include swelling and paresthesia. It is characterized by the presence of rounded + islands of malignant epithelial cells in a fibrous stroma and the benign features + of calcifying cystic odontogenic tumor. The clinical course varies from slow + growing and locally invasive to rapidly growing and highly aggressive with metastases. + termDef: + term: >- + Ghost Cell Odontogenic Carcinoma + source: NCIt + cde_id: C4311 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4311" + term_id: C4311 + term_version: 20.05a + +giant_cell_and_spindle_cell_carcinoma: + common: + description: >- + A malignant epithelial neoplasm composed of giant, pleomorphic cells and spindle + cells. + termDef: + term: >- + Giant Cell and Spindle Cell Carcinoma + source: NCIt + cde_id: C65160 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65160" + term_id: C65160 + term_version: 20.05a + +giant_cell_angiofibroma: + common: + description: >- + A morphologic variant of angiofibroma characterized by the presence of multinucleated + giant cells, collagenous or myxoid stroma, focal sclerotic areas, and angiectoid + spaces. + termDef: + term: >- + Giant Cell Angiofibroma + source: NCIt + cde_id: C27256 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27256" + term_id: C27256 + term_version: 20.05a + +giant_cell_carcinoma: + common: + description: >- + A malignant epithelial neoplasm composed of giant, pleomorphic cells. + termDef: + term: >- + Giant Cell Carcinoma + source: NCIt + cde_id: C3779 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3779" + term_id: C3779 + term_version: 20.05a + +giant_cell_fibroblastoma: + common: + description: >- + A rare, locally aggressive fibroblastic neoplasm typically affecting young patients + (predominantly boys). It manifests with painless nodules in the dermis or subcutaneous + tissues. Morphologically, it contains giant cells and wide vessel-like spaces. This + tumor can recur but metastases have not been reported. + termDef: + term: >- + Giant Cell Fibroblastoma + source: NCIt + cde_id: C4700 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4700" + term_id: C4700 + term_version: 20.05a + +giant_cell_glioblastoma: + common: + description: >- + A rare histological variant of glioblastoma (WHO grade IV) with a predominance + of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin + network, and a high frequency of TP53 mutations. (WHO) + termDef: + term: >- + Giant Cell Glioblastoma + source: NCIt + cde_id: C4325 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4325" + term_id: C4325 + term_version: 20.05a + +giant_cell_sarcoma: + common: + description: >- + A sarcoma characterized by the presence of large, anaplastic malignant cells. + termDef: + term: >- + Giant Cell Sarcoma + source: NCIt + cde_id: C66759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66759" + term_id: C66759 + term_version: 20.05a + +giant_cell_sarcoma_of_bone: + common: + description: >- + A malignant tumor that arises from the bone. It is characterized by the presence + of an area of high grade sarcoma in an otherwise typical giant cell tumor (primary + malignancy in giant cell tumor), or the presence of sarcoma in which the pre-existing + giant cell tumor may or may not be apparent (secondary malignancy in giant cell + tumor). + termDef: + term: >- + Malignancy in Giant Cell Tumor of Bone + source: NCIt + cde_id: C4304 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4304" + term_id: C4304 + term_version: 20.05a + +giant_cell_tumor_of_bone_malignant: + common: + description: >- + A malignant tumor that arises from the bone. It is characterized by the presence + of an area of high grade sarcoma in an otherwise typical giant cell tumor (primary + malignancy in giant cell tumor), or the presence of sarcoma in which the pre-existing + giant cell tumor may or may not be apparent (secondary malignancy in giant cell + tumor). + termDef: + term: >- + Malignancy in Giant Cell Tumor of Bone + source: NCIt + cde_id: C4304 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4304" + term_id: C4304 + term_version: 20.05a + +giant_cell_tumor_of_bone_nos: + common: + description: >- + A benign but locally aggressive tumor that arises from the bone and is composed + of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It + usually arises from the ends of long bones or the vertebrae. Clinical presentation + includes pain, edema, and decreased range of motion in the affected joint. + termDef: + term: >- + Giant Cell Tumor of Bone + source: NCIt + cde_id: C121932 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121932" + term_id: C121932 + term_version: 20.05a + +giant_cell_tumor_of_soft_parts_nos: + common: + description: >- + A painless, well circumscribed tumor arising in soft tissue, usually of the + upper and lower extremities. Morphologically, it is characterized by a multinodular + growth pattern. The cellular infiltrate is composed of mononuclear round or + oval cells and multinucleated osteoclast-like giant cells, in a rich vascular + stroma. It rarely metastasizes. + termDef: + term: >- + Giant Cell Tumor of Soft Tissue + source: NCIt + cde_id: C49107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49107" + term_id: C49107 + term_version: 20.05a + +giant_cell_tumor_of_tendon_sheath: + common: + description: >- + A tumor usually arising in the synovium of joints, bursa or tendon sheath. It + is characterized by the presence of mononuclear cells, multinucleated osteoclast-like + giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory + infiltrate. According to the growth pattern, it is classified as localized or + diffuse. + termDef: + term: >- + Tenosynovial Giant Cell Tumor + source: NCIt + cde_id: C3402 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3402" + term_id: C3402 + term_version: 20.05a + +giant_cell_tumor_of_tendon_sheath_malignant: + common: + description: >- + An uncommon malignant tumor arising from the tendon sheath. Morphologically, + it is characterized by the presence of a cellular infiltrate reminiscent of + a giant cell tumor with prominent malignant characteristics. Recurrent giant + cell tumors with a sarcomatous dedifferentiation are included in this category + as well. + termDef: + term: >- + Malignant Tenosynovial Giant Cell Tumor + source: NCIt + cde_id: C6535 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6535" + term_id: C6535 + term_version: 20.05a + +giant_fibroadenoma: + common: + description: >- + A breast fibroadenoma characterized by a very large size. This term has also + been used as a synonym for juvenile fibroadenoma by some authors. The latter + is characterized by epithelial hyperplasia and an increased stromal cellularity. + termDef: + term: >- + Breast Giant Fibroadenoma + source: NCIt + cde_id: C4273 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4273" + term_id: C4273 + term_version: 20.05a + +giant_osteoid_osteoma: + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the spine. It is a + well-circumscribed lytic tumor that varies in size. The tumor is composed of + woven bone trabeculae and shares similar histologic characteristics with the + osteoid osteoma. Surgical curettage is the treatment of choice. The prognosis + is excellent. + termDef: + term: >- + Osteoblastoma + source: NCIt + cde_id: C3294 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3294" + term_id: C3294 + term_version: 20.05a + +giant_pigmented_nevus_nos: + common: + description: >- + A rare melanocytic lesion occurring at birth, comprising at least 5% of the + body surface area. It usually presents as a dark brown to black hairy lesion. + Morphologically, it is characterized by the presence of a compound or intradermal + nevus. There is an increased risk of malignant transformation to melanoma, rhabdomyosarcoma, + and poorly differentiated malignant tumors. + termDef: + term: >- + Giant Congenital Nevus + source: NCIt + cde_id: C4234 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4234" + term_id: C4234 + term_version: 20.05a + +gibraltar: + common: + description: >- + A dependency in southwestern Europe, on the southern coast of Spain, bordering + the Strait of Gibraltar. + termDef: + term: >- + Gibraltar + source: NCIt + cde_id: C16638 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16638" + term_id: C16638 + term_version: 19.12e + +gigantiform_cementoma: + common: + description: >- + A rare, benign, slow growing, multifocal, and expansile lesion of the jaws. + Both familiar and sporadic cases have been reported. It is characterized by + a fibroblastic proliferation, cementum, and limited bone formation. + termDef: + term: >- + Gigantiform Cementoma + source: NCIt + cde_id: C8381 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8381" + term_id: C8381 + term_version: 20.05a + +giloralimab: + common: + description: >- + An agonistic monoclonal antibody directed against the B-cell surface antigen + CD40, with potential antineoplastic activity. Upon administration, giloralimab + binds to CD40 on a variety of immune cell types. This induces CD40-dependent + signaling pathways, triggers the proliferation and activation of antigen-presenting + cells (APCs), and activates T-cells. This results in an enhanced cytotoxic T-lymphocyte + (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor + and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed + on various immune cells and plays a key role in the activation of the immune + system. + termDef: + term: >- + Giloralimab + source: NCIt + cde_id: C139553 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139553" + term_id: C139553 + term_version: 20.10d + +giredestrant: + common: + description: >- + An orally available selective estrogen receptor degrader/downregulator (SERD), + with potential antineoplastic activity. Upon oral administration, giredestrant + specifically targets and binds to the estrogen receptor (ER) and induces a conformational + change that promotes ER degradation. This prevents ER-mediated signaling and + inhibits both the growth and survival of ER-expressing cancer cells. + termDef: + term: >- + Giredestrant + source: NCIt + cde_id: C147030 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C147030" + term_id: C147030 + term_version: 20.10d + +gist_benign: + common: + description: >- + A gastrointestinal stromal tumor that is characterized by a maximum diameter + equal or less than 5 cm (gastric localization), or equal or less than 2 cm (intestinal + localization) and no more than 5 mitotic figures per 50 high power fields. + termDef: + term: >- + Benign Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C53998 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53998" + term_id: C53998 + term_version: 20.05a + +gist_malignant: + common: + description: >- + A gastrointestinal stromal tumor that is characterized by large size (diameter + greater than 10 cm for gastric localization and greater than 5 cm for intestinal + localization) or more than 5 mitotic figures per 50 high power fields. + termDef: + term: >- + Malignant Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C53999 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53999" + term_id: C53999 + term_version: 20.05a + +gist_nos: + common: + description: >- + A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases + of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal + gastrointestinal stromal tumor). It is a tumor that differentiates along the + lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating + mutations. Until recently, surgery has been the only effective therapy for this + tumor. However, many patients still experience recurrence. Conventional chemotherapy + and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, + imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the + treatment of relapsed and unresectable cases. + termDef: + term: >- + Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C3868 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3868" + term_id: C3868 + term_version: 20.05a + +glandular_intraepithelial_neoplasia_grade_i: + common: + description: >- + Low Grade Glandular Intraepithelial Neoplasia + termDef: + term: >- + Low Grade Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: C7661 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7661" + term_id: C7661 + term_version: 20.05a + +glandular_intraepithelial_neoplasia_grade_ii: + common: + description: >- + Grade II Glandular Intraepithelial Neoplasia + termDef: + term: >- + Grade II Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: C7660 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7660" + term_id: C7660 + term_version: 20.05a + +glandular_intraepithelial_neoplasia_grade_iii: + common: + description: >- + A high grade intraepithelial neoplasia in which there is marked architectural + distortion and crowding of the glands, associated with severe cellular atypia. + The neoplastic cells display pleomorphic and hyperchromatic nuclei. + termDef: + term: >- + Grade III Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: C6877 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6877" + term_id: C6877 + term_version: 20.05a + +glandular_intraepithelial_neoplasia_high_grade: + common: + description: >- + This lesion shows moderate or marked architectural distortion with glandular + crowding and prominent cellular atypia. It includes moderate dysplasia and + severe dysplasia. (WHO, 2000) + termDef: + term: >- + High Grade Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: C7662 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7662" + term_id: C7662 + term_version: 20.05a + +glandular_intraepithelial_neoplasia_low_grade: + common: + description: >- + Low Grade Glandular Intraepithelial Neoplasia + termDef: + term: >- + Low Grade Glandular Intraepithelial Neoplasia + source: NCIt + cde_id: C7661 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7661" + term_id: C7661 + term_version: 20.05a + +glandular_papilloma: + common: + description: >- + Glandular Papilloma + termDef: + term: >- + Glandular Papilloma + source: NCIt + cde_id: C6880 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6880" + term_id: C6880 + term_version: 20.05a + +glans_penis: + common: + description: >- + The most distal portion of the penis covered by the foreskin. + termDef: + term: >- + Glans Penis + source: NCIt + cde_id: C12324 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12324" + term_id: C12324 + term_version: 20.05a + +glassy_cell_carcinoma: + common: + description: >- + A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm. + termDef: + term: >- + Glassy Cell Carcinoma + source: NCIt + cde_id: C65159 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65159" + term_id: C65159 + term_version: 20.05a + +gli1: + common: + description: >- + This gene plays a regulatory role in transcription and embryonic development. + termDef: + term: >- + GLI1 Gene + source: NCIt + cde_id: C24432 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24432" + term_id: C24432 + term_version: 20.10d + +glioblastoma: + common: + description: >- + The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly + differentiated neoplastic astrocytes and it is characterized by the presence + of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, + microvascular proliferation and necrosis. It typically affects adults and is + preferentially located in the cerebral hemispheres. It may develop from diffuse + astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, + IDH-mutant), but more frequently, it manifests after a short clinical history + de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, + IDH- wildtype). (Adapted from WHO) + termDef: + term: >- + Glioblastoma + source: NCIt + cde_id: C3058 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3058" + term_id: C3058 + term_version: 19.12e + +glioblastoma_idh_wildtype: + common: + description: >- + A glioblastoma that arises de novo. It is more commonly seen in older patients. + Mutations in IDH1 or IDH2 genes are not present. + termDef: + term: >- + Glioblastoma, IDH-Wildtype + source: NCIt + cde_id: C39750 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39750" + term_id: C39750 + term_version: 20.05a + +glioblastoma_idhmutant: + common: + description: >- + A glioblastoma associated with IDH1 or IDH2 gene mutations. + termDef: + term: >- + Glioblastoma, IDH-Mutant + source: NCIt + cde_id: C167335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167335" + term_id: C167335 + term_version: 20.05a + +glioblastoma_multiforme: + common: + description: >- + The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly + differentiated neoplastic astrocytes and it is characterized by the presence + of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, + microvascular proliferation and necrosis. It typically affects adults and is + preferentially located in the cerebral hemispheres. It may develop from diffuse + astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, + IDH-mutant), but more frequently, it manifests after a short clinical history + de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, + IDH- wildtype). (Adapted from WHO) + termDef: + term: >- + Glioblastoma + source: NCIt + cde_id: C3058 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3058" + term_id: C3058 + term_version: 20.05a + +glioblastoma_with_sarcomatous_component: + common: + description: >- + A rare histological variant of glioblastoma (WHO grade IV) characterized by + a biphasic tissue pattern with alternating areas displaying glial and mesenchymal + differentiation (WHO). + termDef: + term: >- + Gliosarcoma + source: NCIt + cde_id: C3796 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3796" + term_id: C3796 + term_version: 20.05a + +gliofibroma: + common: + description: >- + An astrocytic tumor affecting young people. Morphologically, it is characterized + by the presence of collagenous tissue surrounding neoplastic astrocytes. In + some cases the collagen is produced by the tumor cells (desmoplastic astrocytoma), + whereas in others it is produced by mesenchymal cells (mixed glioma/fibroma). + termDef: + term: >- + Gliofibroma + source: NCIt + cde_id: C5419 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5419" + term_id: C5419 + term_version: 20.05a + +glioma_malignant: + common: + description: >- + A grade III or grade IV glioma arising from the central nervous system. This + category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, + anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. + termDef: + term: >- + Malignant Glioma + source: NCIt + cde_id: C4822 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4822" + term_id: C4822 + term_version: 20.05a + +glioma_nos: + common: + description: >- + A benign or malignant brain and spinal cord tumor that arises from glial cells + (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes + are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes + are called oligodendroglial tumors. Tumors that arise from ependymal cells are + called ependymomas. + termDef: + term: >- + Glioma + source: NCIt + cde_id: C3059 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3059" + term_id: C3059 + term_version: 20.05a + +gliomatosis_cerebri: + common: + description: >- + A diffuse glial tumor which infiltrates the brain extensively, involving more + than two lobes. It is frequently bilateral and often extends to the infratentorial + structures, even to the spinal cord. It is probably of astrocytic origin, although + GFAP expression may be scant or absent. (Adapted from WHO.) + termDef: + term: >- + Gliomatosis Cerebri + source: NCIt + cde_id: C4318 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4318" + term_id: C4318 + term_version: 20.05a + +glioneuroma: + common: + description: >- + A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, + mature ganglion cells and neoplastic glial cells. Some gangliogliomas show anaplastic + features in their glial component and are considered to be WHO grade III. Rare + cases of newly diagnosed gangliogliomas with grade IV (glioblastoma) changes + in the glial component have also been reported. (Adapted from WHO) + termDef: + term: >- + Ganglioglioma + source: NCIt + cde_id: C3788 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3788" + term_id: C3788 + term_version: 20.05a + +gliosarcoma: + common: + description: >- + A rare histological variant of glioblastoma (WHO grade IV) characterized by + a biphasic tissue pattern with alternating areas displaying glial and mesenchymal + differentiation (WHO). + termDef: + term: >- + Gliosarcoma + source: NCIt + cde_id: C3796 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3796" + term_id: C3796 + term_version: 20.05a + +glofitamab: + common: + description: >- + A bispecific monoclonal antibody, with potential antineoplastic activity. Glofitamab + contains two antigen-recognition sites: one for human CD3, a T cell surface + antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively + expressed on B-cells during most stages of B-cell development and is often overexpressed + in B-cell malignancies. Upon administration, glofitamab binds to both T-cells + and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger + a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor + B-cells. + termDef: + term: >- + Glofitamab + source: NCIt + cde_id: C148486 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148486" + term_id: C148486 + term_version: 20.10d + +glomangioma: + common: + description: >- + A morphologic variant of the glomus tumor characterized by the presence of dilated + veins, surrounded by small clusters of glomus cells. Glomangiomas are most often + present in patients with multiple lesions. + termDef: + term: >- + Glomangioma + source: NCIt + cde_id: C4222 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4222" + term_id: C4222 + term_version: 20.05a + +glomangiomyoma: + common: + description: >- + A morphologic variant of the glomus tumor with architectural features similar + to solid glomus tumor. It is characterized by the presence of elongated glomus + cells which resemble mature smooth muscle. + termDef: + term: >- + Glomangiomyoma + source: NCIt + cde_id: C4223 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4223" + term_id: C4223 + term_version: 20.05a + +glomangiosarcoma: + common: + description: >- + A very rare morphologic variant of glomus tumor with a size greater than 2 cm. The + tumor arises in subfascial or visceral tissues. It is characterized by the presence + of atypical mitotic figures, or marked nuclear atypia, or the combination of + both. It has an aggressive clinical course. + termDef: + term: >- + Malignant Glomus Tumor + source: NCIt + cde_id: C4221 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4221" + term_id: C4221 + term_version: 20.05a + +glomoid_sarcoma: + common: + description: >- + A very rare morphologic variant of glomus tumor with a size greater than 2 cm. The + tumor arises in subfascial or visceral tissues. It is characterized by the presence + of atypical mitotic figures, or marked nuclear atypia, or the combination of + both. It has an aggressive clinical course. + termDef: + term: >- + Malignant Glomus Tumor + source: NCIt + cde_id: C4221 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4221" + term_id: C4221 + term_version: 20.05a + +glomus_jugulare_tumor_nos: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma arising from + paraganglia in the base of the skull and middle ear. + termDef: + term: >- + Jugulotympanic Paraganglioma + source: NCIt + cde_id: C3061 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3061" + term_id: C3061 + term_version: 20.05a + +glomus_tumor_malignant: + common: + description: >- + A very rare morphologic variant of glomus tumor with a size greater than 2 cm. The + tumor arises in subfascial or visceral tissues. It is characterized by the presence + of atypical mitotic figures, or marked nuclear atypia, or the combination of + both. It has an aggressive clinical course. + termDef: + term: >- + Malignant Glomus Tumor + source: NCIt + cde_id: C4221 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4221" + term_id: C4221 + term_version: 20.05a + +glomus_tumor_nos: + common: + description: >- + A rare benign or malignant mesenchymal neoplasm arising from cells that resemble + the modified smooth muscle cells of the glomus body. The majority of glomus + tumors occur in the distal extremities. + termDef: + term: >- + Glomus Tumor + source: NCIt + cde_id: C3060 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3060" + term_id: C3060 + term_version: 20.05a + +glottis: + common: + description: >- + The space in which the vocal cords are located. + termDef: + term: >- + Glottis + source: NCIt + cde_id: C12724 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12724" + term_id: C12724 + term_version: 20.05a + +glucagonoma_malignant: + common: + description: >- + A glucagon-producing neuroendocrine tumor arising from the alpha cells of the + pancreas. It may be associated with necrolytic erythema migrans, diarrhea, + diabetes, glossitis, weight loss, malabsorption, and anemia. It displays vascular + invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Pancreatic Glucagonoma + source: NCIt + cde_id: C65187 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65187" + term_id: C65187 + term_version: 20.05a + +glucose: + common: + description: >- + The determination of the amount of glucose present in a sample. + termDef: + term: >- + Glucose Measurement + source: NCIt + cde_id: C105585 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C105585" + term_id: C105585 + term_version: 20.10d + +glutaminase_inhibitor_ipn60090: + common: + description: >- + An orally bioavailable inhibitor of glutaminase, with potential antineoplastic + and immunostimulating activities. Upon oral administration, IPN60090 selectively + targets, binds to and inhibits human glutaminase, an enzyme that is essential + for the conversion of the amino acid glutamine into glutamate. Blocking glutamine + metabolism inhibits proliferation in rapidly growing tumor cells and leads to + an induction of cell death. Unlike normal healthy cells, glutamine-dependent + tumors heavily rely on the intracellular conversion of exogenous glutamine into + glutamate and glutamate metabolites to provide energy and generate building + blocks for the production of macromolecules, which are needed for cellular growth + and survival. + termDef: + term: >- + Glutaminase Inhibitor IPN60090 + source: NCIt + cde_id: C165612 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165612" + term_id: C165612 + term_version: 20.10d + +glutamine_antagonist_drp104: + common: + description: >- + A broad acting glutamine antagonist, with potential immunomodulatory and antineoplastic + activities. Upon administration, DON (6-Diazo-5-oxo-L-norleucine), the active + moiety of DRP-104, irreversibly inhibits multiple enzymes involved in glutamine + metabolism. Blocking glutamine metabolism inhibits proliferation in rapidly + growing tumor cells and leads to an induction of cell death. Unlike normal healthy + cells, glutamine-dependent tumors rely heavily on the intracellular conversion + of exogenous glutamine into glutamate and glutamate metabolites to both provide + energy and generate building blocks for the production of macromolecules, which + are needed for cellular growth and survival. In addition, blocking glutamine + metabolism leads to the accumulation of glutamine in tumor cells and increases + glutamine concentration in the tumor microenvironment (TME) upon tumor cell + death. As glutamine is essential for T-cell generation, DON may also enhance + T-cell proliferation and activation in the TME, which may lead to further killing + of tumor cells. The conversion of DRP-104 to the active moiety DON occurs primarily + in tumor cells, allowing glutamine metabolism in healthy cells which may lessen + adverse effects. + termDef: + term: >- + Glutamine Antagonist DRP-104 + source: NCIt + cde_id: C174038 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174038" + term_id: C174038 + term_version: 20.10d + +glycogenrich_carcinoma: + common: + description: >- + A carcinoma characterized by the presence of malignant epithelial cells with + abundant clear cytoplasm which contains glycogen. A representative example is + the glycogen-rich, clear cell breast carcinoma. + termDef: + term: >- + Glycogen-Rich Carcinoma + source: NCIt + cde_id: C4153 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4153" + term_id: C4153 + term_version: 20.05a + +gmps: + common: + description: >- + This gene plays a role in nucleotide biosynthesis. + termDef: + term: >- + GMPS Gene + source: NCIt + cde_id: C97522 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97522" + term_id: C97522 + term_version: 20.10d + +gna11: + common: + description: >- + This gene is involved in signal transduction. + termDef: + term: >- + GNA11 Gene + source: NCIt + cde_id: C89717 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C89717" + term_id: C89717 + term_version: 20.10d + +gnaq: + common: + description: >- + This gene plays a role in signal transduction and is involved in calcium signaling. + termDef: + term: >- + GNAQ Gene + source: NCIt + cde_id: C38316 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38316" + term_id: C38316 + term_version: 20.10d + +gnas: + common: + description: >- + This gene plays a role in signal transduction and is associated with pituitary + tumors. + termDef: + term: >- + GNAS Gene + source: NCIt + cde_id: C38317 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38317" + term_id: C38317 + term_version: 20.10d + +goblet_cell_carcinoid: + common: + description: >- + A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells + with morphologic and immunohistochemical characteristics of carcinoid tumor + and malignant glandular cells. + termDef: + term: >- + Combined Carcinoid and Adenocarcinoma + source: NCIt + cde_id: C4139 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4139" + term_id: C4139 + term_version: 20.05a + +golga5: + common: + description: >- + This gene is involved in Golgi maintenance. + termDef: + term: >- + GOLGA5 Gene + source: NCIt + cde_id: C97543 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97543" + term_id: C97543 + term_version: 20.10d + +gonadal_stromal_tumor_nos: + common: + description: >- + A neoplasm arising in the ovary or testis. It is composed of granulosa cells, + Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute + the only cellular component that is present in the neoplasm or it may be mixed + with other cell types in various combinations. The prognosis can not always + be predicted on histologic grounds alone. Approximately, 10% of these tumors + may metastasize. Representative examples include granulosa cell tumor, Leydig + cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group. + termDef: + term: >- + Sex Cord-Stromal Tumor + source: NCIt + cde_id: C3794 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3794" + term_id: C3794 + term_version: 20.05a + +gonadoblastoma: + common: + description: >- + A mixed germ cell/sex cord-stromal tumor characterized by the presence of large + germ cells which resemble seminoma cells and small cells which resemble Sertoli + or granulosa cells. It occurs in the testis and the ovary and is identified + in children and adults. It is often associated with gonadal dysgenesis and abnormal + karyotype. + termDef: + term: >- + Gonadoblastoma + source: NCIt + cde_id: C3754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3754" + term_id: C3754 + term_version: 20.05a + +gonocytoma: + common: + description: >- + A mixed germ cell/sex cord-stromal tumor characterized by the presence of large + germ cells which resemble seminoma cells and small cells which resemble Sertoli + or granulosa cells. It occurs in the testis and the ovary and is identified + in children and adults. It is often associated with gonadal dysgenesis and abnormal + karyotype. + termDef: + term: >- + Gonadoblastoma + source: NCIt + cde_id: C3754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3754" + term_id: C3754 + term_version: 20.05a + +gopc: + common: + description: >- + This gene plays a role in protein transport. + termDef: + term: >- + GOPC Gene + source: NCIt + cde_id: C97546 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97546" + term_id: C97546 + term_version: 20.10d + +gpc3: + common: + description: >- + This gene is involved in heparin sulfate binding. + termDef: + term: >- + GPC3 Gene + source: NCIt + cde_id: C88173 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C88173" + term_id: C88173 + term_version: 20.10d + +gphn: + common: + description: >- + This gene is involved in vitamin metabolism. + termDef: + term: >- + GPHN Gene + source: NCIt + cde_id: C97525 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97525" + term_id: C97525 + term_version: 20.10d + +grand_nephew: + common: + description: >- + A male child of one's niece or nephew. + termDef: + term: >- + Great Nephew + source: NCIt + cde_id: C165798 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165798" + term_id: C165798 + term_version: 19.12e + +grand_niece: + common: + description: >- + A female child of one's niece or nephew. + termDef: + term: >- + Great Niece + source: NCIt + cde_id: C165846 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165846" + term_id: C165846 + term_version: 19.12e + +grandchild: + common: + description: >- + A child of your son or daughter. + termDef: + term: >- + Grandchild + source: NCIt + cde_id: C71397 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71397" + term_id: C71397 + term_version: 19.12e + +granddaughter: + common: + description: >- + A female grandchild. + termDef: + term: >- + Granddaughter + source: NCIt + cde_id: C71399 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71399" + term_id: C71399 + term_version: 19.12e + +grandfather: + common: + description: >- + The father of your father or mother. + termDef: + term: >- + Grandfather + source: NCIt + cde_id: C71387 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71387" + term_id: C71387 + term_version: 19.12e + +grandmother: + common: + description: >- + The mother of your father or mother. + termDef: + term: >- + Grandmother + source: NCIt + cde_id: C71386 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71386" + term_id: C71386 + term_version: 19.12e + +grandparent: + common: + description: >- + A parent of your father or mother. + termDef: + term: >- + Grandparent + source: NCIt + cde_id: C71385 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71385" + term_id: C71385 + term_version: 19.12e + +grandson: + common: + description: >- + A male grandchild. + termDef: + term: >- + Grandson + source: NCIt + cde_id: C71398 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71398" + term_id: C71398 + term_version: 19.12e + +granular_cell_adenocarcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of malignant epithelial cells + with granular cytoplasm. + termDef: + term: >- + Granular Cell Carcinoma + source: NCIt + cde_id: C3681 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3681" + term_id: C3681 + term_version: 20.05a + +granular_cell_carcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of malignant epithelial cells + with granular cytoplasm. + termDef: + term: >- + Granular Cell Carcinoma + source: NCIt + cde_id: C3681 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3681" + term_id: C3681 + term_version: 20.05a + +granular_cell_myoblastoma_malignant: + common: + description: >- + An uncommon granular cell tumor which may metastasize to other anatomic sites. + Morphologic characteristics include the presence of spindling neoplastic cells, + necrosis, extensive pleomorphism, prominent nucleoli, and increased mitiotic + activity. + termDef: + term: >- + Malignant Granular Cell Tumor + source: NCIt + cde_id: C4336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4336" + term_id: C4336 + term_version: 20.05a + +granular_cell_myoblastoma_nos: + common: + description: >- + An unusual benign or malignant neoplasm characterized by the presence of neoplastic + large polygonal cells with granular, eosinophilic cytoplasm which contains abundant + lysosomes. It was originally thought to be a tumor originating from muscle cells + and was named granular cell myoblastoma. Subsequent studies have suggested a + derivation from Schwann cells. It affects females more often than males and + it usually presents as a solitary mass. A minority of patients have multiple + tumors. It can arise from many anatomic sites including the posterior pituitary + gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast. + termDef: + term: >- + Granular Cell Tumor + source: NCIt + cde_id: C3474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3474" + term_id: C3474 + term_version: 20.05a + +granular_cell_tumor_malignant: + common: + description: >- + An uncommon granular cell tumor which may metastasize to other anatomic sites. + Morphologic characteristics include the presence of spindling neoplastic cells, + necrosis, extensive pleomorphism, prominent nucleoli, and increased mitiotic + activity. + termDef: + term: >- + Malignant Granular Cell Tumor + source: NCIt + cde_id: C4336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4336" + term_id: C4336 + term_version: 20.05a + +granular_cell_tumor_nos: + common: + description: >- + An unusual benign or malignant neoplasm characterized by the presence of neoplastic + large polygonal cells with granular, eosinophilic cytoplasm which contains abundant + lysosomes. It was originally thought to be a tumor originating from muscle cells + and was named granular cell myoblastoma. Subsequent studies have suggested a + derivation from Schwann cells. It affects females more often than males and + it usually presents as a solitary mass. A minority of patients have multiple + tumors. It can arise from many anatomic sites including the posterior pituitary + gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast. + termDef: + term: >- + Granular Cell Tumor + source: NCIt + cde_id: C3474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3474" + term_id: C3474 + term_version: 20.05a + +granular_cell_tumor_of_the_sellar_region: + common: + description: >- + A generally benign intrasellar and/or suprasellar mass arising from the neurohypophysis + or infundibulum. It is composed of nests of large cells with granular, eosinophilic + cytoplasm due to abundant intracytoplasmic lysosomes. It generally has a slow + progression and lacks invasive growth. (Adapted from WHO) + termDef: + term: >- + Granular Cell Tumor of the Sellar Region + source: NCIt + cde_id: C7017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7017" + term_id: C7017 + term_version: 20.05a + +granulocyte: + common: + description: >- + A type of leukocyte with a multilobed nucleus and cytoplasmic granules. The + unique morphology of the nucleus has led to their also being known as polymorphonuclear + leukocytes (PMLs or PMNs). Granulocytes are subdivided according to the staining + properties of their granules into eosinophils (red with acidic dye), basophils + (blue with basic dye), and neutrophils (not amenable to staining with either + acidic or basic dyes). + termDef: + term: >- + Granulocyte + source: NCIt + cde_id: C12530 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12530" + term_id: C12530 + term_version: 20.10d + +granulocytic_leukemia_nos: + common: + description: >- + A clonal proliferation of myeloid cells and their precursors in the bone marrow, + peripheral blood, and spleen. When the proliferating cells are immature myeloid + cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating + myeloid cells are neutrophils, it is called chronic myelogenous leukemia. + termDef: + term: >- + Myeloid Leukemia + source: NCIt + cde_id: C3172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3172" + term_id: C3172 + term_version: 20.05a + +granulocytic_sarcoma: + common: + description: >- + A tumor mass composed of myeloblasts, neutrophils and neutrophil precursors. Granulocytic + sarcoma is the most common type of myeloid sarcoma. (WHO, 2001) + termDef: + term: >- + Granulocytic Sarcoma + source: NCIt + cde_id: C35815 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35815" + term_id: C35815 + term_version: 20.05a + +granulosa_cell_carcinoma: + common: + description: >- + A granulosa cell tumor which has an aggressive clinical course and metastasizes + to other anatomic sites. + termDef: + term: >- + Malignant Granulosa Cell Tumor + source: NCIt + cde_id: C4205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4205" + term_id: C4205 + term_version: 20.05a + +granulosa_cell_tumor_adult_type: + common: + description: >- + A granulosa cell tumor occurring in the ovary and rarely in the testis. It is + composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic + cells may form various patterns including the microfollicular, which is characterized + by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, + and diffuse pattern. In females, it affects middle aged to post-menopausal women. + Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic + and rarely androgenic manifestations may be present. The vast majority of cases + present as stage I tumors; however, all tumors have a potential for aggressive + clinical course. In males, it is reported in the age range of 16-76 years and + the average age at presentation is 44 years. A minority of patients have gynecomastia. + Metastases have been reported in a minority of patients. + termDef: + term: >- + Adult Type Granulosa Cell Tumor + source: NCIt + cde_id: C66750 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66750" + term_id: C66750 + term_version: 20.05a + +granulosa_cell_tumor_juvenile: + common: + description: >- + A granulosa cell tumor occurring in the ovary and testis. In females it occurs + predominantly in the first three decades of life and presents unilaterally as + stage I disease in the vast majority of cases. It is characterized by the presence + of granulosa cells forming macrofollicular structures. The majority of cases + have a good prognosis. In males it represents the most frequent congenital testicular + neoplasm and the vast majority of cases occur in the perinatal period. It presents + as a scrotal or abdominal mass and it more often affects the left testis. Approximately + 20% of the patients have ambiguous external genitalia. It is characterized by + the presence of cystic spaces lined by granulosa cells and cells resembling + theca cells. Metastases have not been reported. + termDef: + term: >- + Juvenile Type Granulosa Cell Tumor + source: NCIt + cde_id: C4207 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4207" + term_id: C4207 + term_version: 20.05a + +granulosa_cell_tumor_malignant: + common: + description: >- + A granulosa cell tumor which has an aggressive clinical course and metastasizes + to other anatomic sites. + termDef: + term: >- + Malignant Granulosa Cell Tumor + source: NCIt + cde_id: C4205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4205" + term_id: C4205 + term_version: 20.05a + +granulosa_cell_tumor_nos: + common: + description: >- + A slow-growing, malignant tumor, characterized by the presence of granulosa-like + cells and Call-Exner bodies, that is almost always found in the ovary. In rare + cases, it has also been found in the testicle. There are two types of granulosa + cell tumors that can be distinguished under the microscope: the adult and the + juvenile. The testicular juvenile granulosa cell tumors are perhaps the most + common congenital testicular neoplasms. + termDef: + term: >- + Granulosa Cell Tumor + source: NCIt + cde_id: C3070 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3070" + term_id: C3070 + term_version: 20.05a + +granulosa_celltheca_cell_tumor: + common: + description: >- + A general term used to describe sex cord-stromal tumors characterized by the + presence of granulosa cells in a thecomatous/fibrothecomatous background. + termDef: + term: >- + Granulosa Cell-Theca Cell Tumor + source: NCIt + cde_id: C66751 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66751" + term_id: C66751 + term_version: 20.05a + +grawitz_tumor: + common: + description: >- + A malignant epithelial neoplasm of the kidney characterized by the presence + of lipid-containing clear cells within a vascular network. The tumor may metastasize + to unusual sites and late metastasis is common. + termDef: + term: >- + Clear Cell Renal Cell Carcinoma + source: NCIt + cde_id: C4033 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4033" + term_id: C4033 + term_version: 20.05a + +grease_fire_smoke: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced during a grease fire. + termDef: + term: >- + Grease Fire Smoke Exposure + source: NCIt + cde_id: C164085 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164085" + term_id: C164085 + term_version: 19.12e + +great_grandchild: + common: + description: >- + A child of one's grandchild. + termDef: + term: >- + Great Grandchild + source: NCIt + cde_id: C165847 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165847" + term_id: C165847 + term_version: 19.12e + +greater_curvature_of_stomach_nos: + common: + description: >- + The lateral and inferior border of the stomach. Attached to it is the greater + omentum. + termDef: + term: >- + Greater Curvature of the Stomach + source: NCIt + cde_id: C12262 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12262" + term_id: C12262 + term_version: 20.05a + +greece: + common: + description: >- + A country in southern Europe, bordering the Aegean, Ionian, and Mediterranean + Seas, between Albania and Turkey. + termDef: + term: >- + Greece + source: NCIt + cde_id: C16645 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16645" + term_id: C16645 + term_version: 19.12e + +greenland: + common: + description: >- + An island between the Arctic Ocean and the North Atlantic Ocean, northeast of + Canada. + termDef: + term: >- + Greenland + source: NCIt + cde_id: C16646 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16646" + term_id: C16646 + term_version: 19.12e + +grenada: + common: + description: >- + An island between the Caribbean Sea and Atlantic Ocean, south of Saint Vincent + and the Grenadines and north of Trinidad and Tobago. + termDef: + term: >- + Grenada + source: NCIt + cde_id: C16647 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16647" + term_id: C16647 + term_version: 19.12e + +grilling_smoke: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates emitted by an indoor or outdoor grill used for cooking. + termDef: + term: >- + Grilling Smoke Exposure + source: NCIt + cde_id: C164086 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164086" + term_id: C164086 + term_version: 19.12e + +grin2a: + common: + description: >- + This gene is involved in the regulation of ion transport. + termDef: + term: >- + GRIN2A Gene + source: NCIt + cde_id: C98146 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98146" + term_id: C98146 + term_version: 20.10d + +grm3: + common: + description: >- + This gene is involved in ligand-depending signaling. + termDef: + term: >- + GRM3 Gene + source: NCIt + cde_id: C114529 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C114529" + term_id: C114529 + term_version: 20.10d + +groin: + common: + description: >- + The lower region of the anterior abdominal wall located laterally to the pubic + region. + termDef: + term: >- + Inguinal Region + source: NCIt + cde_id: C12726 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12726" + term_id: C12726 + term_version: 20.05a + +group_1: + common: + description: >- + Only individual discrete well-formed glands. + termDef: + term: >- + Gleason Grade Group 1 + source: NCIt + cde_id: C137992 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137992" + term_id: C137992 + term_version: 20.05a + +group_2: + common: + description: >- + Predominantly well-formed glands with lesser component of poorly-formed/fused/cribriform + glands. + termDef: + term: >- + Gleason Grade Group 2 + source: NCIt + cde_id: C137993 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137993" + term_id: C137993 + term_version: 20.05a + +group_3: + common: + description: >- + Predominantly poorly-formed/fused/cribriform glands with a lesser component + of well-formed glands. + termDef: + term: >- + Gleason Grade Group 3 + source: NCIt + cde_id: C137994 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137994" + term_id: C137994 + term_version: 20.05a + +group_4: + common: + description: >- + Only poorly-formed/fused/cribriform glands or Predominantly well-formed glands + and lesser component lacking glands or Predominantly lacking glands and lesser + component of well-formed gland. Poorly-formed/fused/cribriform glands can be + a more minor component. + termDef: + term: >- + Gleason Grade Group 4 + source: NCIt + cde_id: C137995 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137995" + term_id: C137995 + term_version: 20.05a + +group_5: + common: + description: >- + Lacks gland formation (or with necrosis) with or without poorly formed/fused/cribriform + glands. For cases with greater than 95% poorly formed/fused/cribriform glands + or lack of glands on a core or at RP, the component of less than 5% well-formed + glands is not factored into the grade. + termDef: + term: >- + Gleason Grade Group 5 + source: NCIt + cde_id: C137996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137996" + term_id: C137996 + term_version: 20.05a + +group_i: + common: + description: >- + Localized disease, excised. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group I + source: NCIt + cde_id: C148012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148012" + term_id: C148012 + term_version: 20.05a + +group_ia: + common: + description: >- + Confined to site of origin. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group Ia + source: NCIt + cde_id: C148013 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148013" + term_id: C148013 + term_version: 20.05a + +group_ib: + common: + description: >- + Infiltrative, beyond site of origin; negative lymph nodes. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group Ib + source: NCIt + cde_id: C148014 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148014" + term_id: C148014 + term_version: 20.05a + +group_ii: + common: + description: >- + Total gross resection with regional disease spread. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group II + source: NCIt + cde_id: C148015 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148015" + term_id: C148015 + term_version: 20.05a + +group_iia: + common: + description: >- + Localized tumor with microscopic residual disease. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group IIa + source: NCIt + cde_id: C148016 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148016" + term_id: C148016 + term_version: 20.05a + +group_iib: + common: + description: >- + Regional disease with positive lymph nodes, excised. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group IIb + source: NCIt + cde_id: C148017 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148017" + term_id: C148017 + term_version: 20.05a + +group_iic: + common: + description: >- + Regional disease with positive lymph nodes. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group IIc + source: NCIt + cde_id: C148018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148018" + term_id: C148018 + term_version: 20.05a + +group_iii: + common: + description: >- + Gross residual disease. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group III + source: NCIt + cde_id: C148019 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148019" + term_id: C148019 + term_version: 20.05a + +group_iiia: + common: + description: >- + Localized or regional disease; biopsy. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group IIIa + source: NCIt + cde_id: C148020 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148020" + term_id: C148020 + term_version: 20.05a + +group_iiib: + common: + description: >- + Localized or regional disease; resection (debulking of more than 50% of tumor). + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group IIIb + source: NCIt + cde_id: C148021 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148021" + term_id: C148021 + term_version: 20.05a + +group_iv: + common: + description: >- + Distant metastasis. + termDef: + term: >- + Intergroup Rhabdomyosarcoma Group IV + source: NCIt + cde_id: C148022 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148022" + term_id: C148022 + term_version: 20.05a + +guadeloupe: + common: + description: >- + A group of islands in the Caribbean Seas, southeast of Montserrat. + termDef: + term: >- + Guadeloupe + source: NCIt + cde_id: C16651 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16651" + term_id: C16651 + term_version: 19.12e + +guam: + common: + description: >- + An island in the North Pacific Ocean, about three-quarters of the way from Hawaii + to the Philippines, south of the Northern Mariana Islands. + termDef: + term: >- + Guam + source: NCIt + cde_id: C16652 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16652" + term_id: C16652 + term_version: 19.12e + +guatemala: + common: + description: >- + A country in Central America, bordering the Caribbean Sea and the North Pacific + Ocean, east of Mexico and west of Belize and Honduras. + termDef: + term: >- + Guatemala + source: NCIt + cde_id: C16654 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16654" + term_id: C16654 + term_version: 19.12e + +guernsey: + common: + description: >- + A British Crown dependency in the English Channel, between England and France. + termDef: + term: >- + Guernsey + source: NCIt + cde_id: C64375 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64375" + term_id: C64375 + term_version: 19.12e + +guinea: + common: + description: >- + A country in western Africa, bordering the North Atlantic Ocean, between Guinea-Bissau + and Sierra Leone. + termDef: + term: >- + Guinea + source: NCIt + cde_id: C16655 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16655" + term_id: C16655 + term_version: 19.12e + +guineabissau: + common: + description: >- + A country in western Africa, bordering the North Atlantic Ocean, between Guinea + and Senegal. + termDef: + term: >- + Guinea-Bissau + source: NCIt + cde_id: C16656 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16656" + term_id: C16656 + term_version: 19.12e + +gum_nos: + common: + description: >- + The soft tissue surrounding the neck of individual teeth as well as covering + the alveolar bone. The tissue is fibrous and continuous with the periodontal + ligament and mucosal covering. + termDef: + term: >- + Gingiva + source: NCIt + cde_id: C32677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32677" + term_id: C32677 + term_version: 20.05a + +guyana: + common: + description: >- + A country in northern South America, bordering the North Atlantic Ocean, between + Suriname and Venezuela. + termDef: + term: >- + Guyana + source: NCIt + cde_id: C16657 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16657" + term_id: C16657 + term_version: 19.12e + +gx: + common: + description: >- + A morphologic qualifier indicating that the grade of a neoplasm cannot be assessed. + termDef: + term: >- + Grade X + source: NCIt + cde_id: C113730 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113730" + term_id: C113730 + term_version: 20.05a + +gynandroblastoma: + common: + description: >- + A rare neoplasm arising from the ovary. Although it may occur at any age, it + is more often seen in young females. Morphologically, it is characterized by + a mixture of two cellular populations: well differentiated Sertoli cells and + granulosa cells, with the latter constituting at least ten percent of the neoplasm. + The vast majority of cases are stage I lesions at presentation and produce either + estrogenic or androgenic manifestations. Although it may present as a massive + ovarian tumor, it usually follows a benign clinical course. Very rare case reports + of testicular lesions morphologically resembling gynandroblastomas are in fact + variants of juvenile granulose cell tumor, or Sertoli cell tumor, or a combination + of both. + termDef: + term: >- + Ovarian Gynandroblastoma + source: NCIt + cde_id: C3072 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3072" + term_id: C3072 + term_version: 20.05a + +gynecologic_cancer: + common: + description: >- + A primary or metastatic malignant neoplasm involving the female reproductive + system. Representative examples include endometrial carcinoma, cervical carcinoma, + ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed + mesodermal (mullerian) tumor, and gestational choriocarcinoma. + termDef: + term: >- + Malignant Female Reproductive System Neoplasm + source: NCIt + cde_id: C4913 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4913" + term_id: C4913 + term_version: 19.12e + +h1: + common: + description: >- + Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin + compaction into higher order structures. Histones are basic nuclear proteins + responsible for the nucleosome structure of eukaryotic chromatin. Repeating + nucleosome units contain two molecules each of core Histones H2A, H2B, H3, and + H4 that form an octamer complex around which approximately 146 base pairs of + DNA is wrapped. (NCI) + termDef: + term: >- + Histone H1 + source: NCIt + cde_id: C16683 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16683" + term_id: C16683 + term_version: 20.10d + +h2a: + common: + description: >- + Slightly lysine rich histone. One of four histones assembled into a nucleosomal + core octamer. Various posttranslationally modified forms and variants exist. + Combines with histone H2B in a heterodimer; two H2A/H2B dimers are incorporated + in the nucleosomal octamer. + termDef: + term: >- + Histone H2A + source: NCIt + cde_id: C16684 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16684" + term_id: C16684 + term_version: 20.10d + +h2abbd: + common: + description: >- + A variant form of histone H2A found in chromatin structures that are transcriptionally + active. + termDef: + term: >- + Histone H2A-Bbd + source: NCIt + cde_id: C154613 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154613" + term_id: C154613 + term_version: 20.10d + +h2ax: + common: + description: >- + Histone H2AX (143 aa, ~15 kDa) is encoded by the human H2AX gene. This protein + plays a role in nucleosome formation and V(D)J recombination. + termDef: + term: >- + Histone H2AX + source: NCIt + cde_id: C19432 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19432" + term_id: C19432 + term_version: 20.10d + +h2az: + common: + description: >- + Histone H2A.Z (128 aa, ~14 kDa) is encoded by the human H2AZ1 gene. This protein + is involved in nucleosome and heterochromatin formation. + termDef: + term: >- + Histone H2A.Z + source: NCIt + cde_id: C126766 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126766" + term_id: C126766 + term_version: 20.10d + +h2az1: + common: + description: >- + Histone H2A.Z (128 aa, ~14 kDa) is encoded by the human H2AZ1 gene. This protein + is involved in nucleosome and heterochromatin formation. + termDef: + term: >- + Histone H2A.Z + source: NCIt + cde_id: C126766 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126766" + term_id: C126766 + term_version: 20.10d + +h2az2: + common: + description: >- + Histone H2A.V (128 aa, ~14 kDa) is encoded by the human H2AZ2 gene. This protein + is involved in nucleosome formation. + termDef: + term: >- + Histone H2A.V + source: NCIt + cde_id: C162832 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C162832" + term_id: C162832 + term_version: 20.10d + +h2az22: + common: + description: >- + Histone H2A.V isoform 2 (114 aa, ~12 kDa) is encoded by the human H2AZ2 gene. + This protein plays a role in nucleosome stability. + termDef: + term: >- + Histone H2A.V Isoform 2 + source: NCIt + cde_id: C162834 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C162834" + term_id: C162834 + term_version: 20.10d + +h2b: + common: + description: >- + Histone H2B is a core subunit of the eukaryotic nucleosome complex. Histones + are basic nuclear proteins responsible for the nucleosome structure of chromatin. + Repeating nucleosome units contain two molecules each of Histones H2A, H2B, + H3, and H4 that form an octamer complex around which approximately 146 base + pairs of DNA is wrapped. Linker Histone H1 interacts with DNA between nucleosome + units in mediating chromatin compaction into higher order structures. (NCI) + termDef: + term: >- + Histone H2B + source: NCIt + cde_id: C17460 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17460" + term_id: C17460 + term_version: 20.10d + +h3: + common: + description: >- + Histone H3 is a core subunit of the eukaryotic nucleosome complex. Histones + are basic nuclear proteins responsible for the nucleosome structure of chromatin. + Repeating nucleosome units contain two molecules each of Histones H2A, H2B, + H3, and H4 that form an octamer complex around which approximately 146 base + pairs of DNA is wrapped. Linker Histone H1 interacts with DNA between nucleosome + units in mediating chromatin compaction into higher order structures. (NCI) + termDef: + term: >- + Histone H3 + source: NCIt + cde_id: C16685 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16685" + term_id: C16685 + term_version: 20.10d + +h31: + common: + description: >- + Histone H3.1 (136 aa, ~15 kDa) is encoded by the human H3C1, H3C2, H3C3, H3C4, + H3C6, H3C7, H3C8, H3C10, H3C11 and H3C12 genes. This protein plays a role in + the formation of chromatin structures. + termDef: + term: >- + Histone H3.1 + source: NCIt + cde_id: C101734 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101734" + term_id: C101734 + term_version: 20.10d + +h32: + common: + description: >- + Histone H3.2 (136 aa, ~15 kDa) is encoded by the human H3C13, H3C14 and H3C15 + genes. This protein plays a role in nucleosome remodeling and chromosomal structure. + termDef: + term: >- + Histone H3.2 + source: NCIt + cde_id: C148067 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148067" + term_id: C148067 + term_version: 20.10d + +h33: + common: + description: >- + Histone H3.3 (136 aa, ~15 kDa) is encoded by both the human H3-3A and H3-3B + genes. This protein plays a role in chromosomal structure. + termDef: + term: >- + Histone H3.3 + source: NCIt + cde_id: C101445 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101445" + term_id: C101445 + term_version: 20.10d + +h35: + common: + description: >- + Histone H3.3C (135 aa, ~15 kDa) is encoded by the human H3-5 gene. This protein + is involved in the modulation of DNA accessibility to the transcriptional machinery. + termDef: + term: >- + Histone H3.3C + source: NCIt + cde_id: C154668 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154668" + term_id: C154668 + term_version: 20.10d + +h3f3a: + common: + description: >- + This gene is involved in chromatin structure. + termDef: + term: >- + H3F3A Gene + source: NCIt + cde_id: C101443 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101443" + term_id: C101443 + term_version: 20.10d + +h3f3b: + common: + description: >- + This gene plays a role in nucleosome assembly. + termDef: + term: >- + H3F3B Gene + source: NCIt + cde_id: C113760 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113760" + term_id: C113760 + term_version: 20.10d + +h3t_h34: + common: + description: >- + Histone H3.1t (136 aa, ~16 kDa) is encoded by the human H3-4 gene. This protein + is involved in formation of higher order chromatin structures. + termDef: + term: >- + Histone H3.1t + source: NCIt + cde_id: C154671 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154671" + term_id: C154671 + term_version: 20.10d + +h3x: + common: + description: >- + Human H3.X gene is located in the vicinity of 5p15.1 and is approximately 0.4 + kb in length. This pseudogene has no formally documented products. + termDef: + term: >- + H3.X Gene + source: NCIt + cde_id: C155735 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155735" + term_id: C155735 + term_version: 20.10d + +h3y: + common: + description: >- + Histone H3.Y (136 aa, ~15 kDa) is encoded by the human H3.Y gene. This protein + may be involved in both transcriptional regulation and the formation of higher + order chromatin structures. + termDef: + term: >- + Histone H3.Y + source: NCIt + cde_id: C155738 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155738" + term_id: C155738 + term_version: 20.10d + +h4: + common: + description: >- + Histone H4 (103 aa, ~11 kDa) is encoded by the human H4C1, H4C2, H4C3, H4C4, + H4C5, H4C6, H4C6, H4C8, H4C9, H4C11, H4C12, H4C13, H4C14, H4C15, H4-16 genes. + This protein plays a role in nucleating the formation of high order chromatin + structures as a part of nucleosomes. + termDef: + term: >- + Histone H4 + source: NCIt + cde_id: C16686 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16686" + term_id: C16686 + term_version: 20.10d + +haemangioblastoma: + common: + description: >- + A WHO grade I tumor of uncertain histogenesis which is composed of stromal cells + and abundant capillaries. Approximately 25% of hemangioblastomas are associated + with Von Hippel-Lindau disease, a disease inherited through an autosomal dominant + trait and characterized by the development of hemangioblastomas of the central + nervous system and retina, clear cell renal carcinoma, pheochromocytoma, and + pancreatic and inner ear tumors. (Adapted from WHO) + termDef: + term: >- + Hemangioblastoma + source: NCIt + cde_id: C3801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3801" + term_id: C3801 + term_version: 20.05a + +haemangiosarcoma: + common: + description: >- + A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, + it is characterized by frequently open vascular anastomosing and branching channels. The + malignant cells that line the vascular channels are spindle or epithelioid and + often display hyperchromatic nuclei. Angiosarcomas most frequently occur in + the skin and breast. Patients with long-standing lymphedema are at increased + risk of developing angiosarcoma. + termDef: + term: >- + Angiosarcoma + source: NCIt + cde_id: C3088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3088" + term_id: C3088 + term_version: 20.05a + +hairy_cell_leukaemia_variant: + common: + description: >- + An indolent chronic B-cell leukemia resembling classic hairy cell leukemia but + shows variant cytologic, hematologic, and immunophenotypic features and is resistant + to the conventional therapy applied to hairy cell leukemia. Biologically, it + is not related to hairy cell leukemia. + termDef: + term: >- + Hairy Cell Leukemia Variant + source: NCIt + cde_id: C7401 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7401" + term_id: C7401 + term_version: 20.05a + +hairy_cell_leukemia: + common: + description: >- + A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, + and peripheral blood. Most patients present with splenomegaly and pancytopenia. + (WHO, 2001) + termDef: + term: >- + Hairy Cell Leukemia + source: NCIt + cde_id: C7402 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7402" + term_id: C7402 + term_version: 20.05a + +hairy_cell_leukemia_variant: + common: + description: >- + An indolent chronic B-cell leukemia resembling classic hairy cell leukemia but + shows variant cytologic, hematologic, and immunophenotypic features and is resistant + to the conventional therapy applied to hairy cell leukemia. Biologically, it + is not related to hairy cell leukemia. + termDef: + term: >- + Hairy Cell Leukemia Variant + source: NCIt + cde_id: C7401 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7401" + term_id: C7401 + term_version: 20.05a + +hairy_nevus: + common: + description: >- + A usually benign congenital skin growth that is often pigmented and sometimes + develop coarse surface hair. There is a lifetime risk of transformation to malignant + melanoma which varies depending on the size of the lesion. + termDef: + term: >- + Hairy Nevus + source: NCIt + cde_id: C3074 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3074" + term_id: C3074 + term_version: 20.05a + +haiti: + common: + description: >- + A country comprising the western one-third of the island of Hispaniola, between + the Caribbean Sea and the North Atlantic Ocean, west of the Dominican Republic. + termDef: + term: >- + Haiti + source: NCIt + cde_id: C16660 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16660" + term_id: C16660 + term_version: 19.12e + +half_brother: + common: + description: >- + A male sibling with whom you share a single parent. + termDef: + term: >- + Half Brother + source: NCIt + cde_id: C71402 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71402" + term_id: C71402 + term_version: 19.12e + +half_sibling: + common: + description: >- + A sibling with whom you share a single parent. + termDef: + term: >- + Half Sibling + source: NCIt + cde_id: C71391 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71391" + term_id: C71391 + term_version: 19.12e + +half_sister: + common: + description: >- + A female sibling with whom you share a single parent. + termDef: + term: >- + Half Sister + source: NCIt + cde_id: C71403 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71403" + term_id: C71403 + term_version: 19.12e + +halo_nevus: + common: + description: >- + A melanocytic nevus characterized by circumferential depigmentation. It is usually + associated with a brisk lymphocytic infiltrate. + termDef: + term: >- + Halo Nevus + source: NCIt + cde_id: C7602 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7602" + term_id: C7602 + term_version: 20.05a + +handschullerchristian_disease: + common: + description: >- + A multifocal, unisystem form of Langerhans-cell histiocytosis. There is involvement + of multiple sites in one organ system, most frequently the bone. Patients are + usually young children presenting with multiple destructive bone lesions. + termDef: + term: >- + Hand-Schuller-Christian Disease + source: NCIt + cde_id: C6920 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6920" + term_id: C6920 + term_version: 20.05a + +hard_palate: + common: + description: >- + The bony anterior part of the roof of the mouth separating the nose from the + mouth. + termDef: + term: >- + Hard Palate + source: NCIt + cde_id: C12230 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12230" + term_id: C12230 + term_version: 20.05a + +hashish_smoke: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced by direct or nearby use of a vaporized or combusted product + made from cannabis plant resin. + termDef: + term: >- + Hashish Smoke Exposure + source: NCIt + cde_id: C164087 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164087" + term_id: C164087 + term_version: 19.12e + +head_and_neck_cancer: + common: + description: >- + A primary or metastatic malignant neoplasm affecting the head and neck. Representative + examples include oral cavity squamous cell carcinoma, laryngeal squamous cell + carcinoma, and salivary gland carcinoma. + termDef: + term: >- + Malignant Head and Neck Neoplasm + source: NCIt + cde_id: C4013 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4013" + term_id: C4013 + term_version: 19.12e + +head_of_pancreas: + common: + description: >- + That portion of the pancreas lying in the concavity of the duodenum. + termDef: + term: >- + Head of the Pancreas + source: NCIt + cde_id: C12269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12269" + term_id: C12269 + term_version: 20.05a + +headaches: + common: + description: >- + Pain in various parts of the head, not confined to the area of distribution + of any nerve. + termDef: + term: >- + Headache + source: NCIt + cde_id: C34661 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C34661" + term_id: C34661 + term_version: 20.05a + +heart: + common: + description: >- + A hollow organ located slightly to the left of the middle portion of the chest. + It is composed of muscle and it is divided by a septum into two sides: the right + side which receives de-oxygenated blood from the body and the left side which + sends newly oxygenated blood to the body. Each side is composed of two chambers: + the atrium (receiving blood) and ventricle (ejecting blood). + termDef: + term: >- + Heart + source: NCIt + cde_id: C12727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12727" + term_id: C12727 + term_version: 20.05a + +heavy_chain_disease_nos: + common: + description: >- + A group of rare disorders of immunoglobulin synthesis associated with B-cell + proliferative disorders. + termDef: + term: >- + Heavy Chain Disease + source: NCIt + cde_id: C3082 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3082" + term_id: C3082 + term_version: 20.05a + +heavy_drinker: + common: + description: >- + A man who drinks more than 14 standard drinks per week or a woman who drinks + more than 7 standard drinks per week. + termDef: + term: >- + Heavy Drinker + source: NCIt + cde_id: C126384 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126384" + term_id: C126384 + term_version: 19.12e + +hemangioblastic_meningioma: + common: + description: >- + An obsolete term referring to hemangiopericytoma of the central nervous system. + termDef: + term: >- + Hemangioblastic Meningioma + source: NCIt + cde_id: C66817 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66817" + term_id: C66817 + term_version: 20.05a + +hemangioendothelial_sarcoma: + common: + description: >- + A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, + it is characterized by frequently open vascular anastomosing and branching channels. The + malignant cells that line the vascular channels are spindle or epithelioid and + often display hyperchromatic nuclei. Angiosarcomas most frequently occur in + the skin and breast. Patients with long-standing lymphedema are at increased + risk of developing angiosarcoma. + termDef: + term: >- + Angiosarcoma + source: NCIt + cde_id: C3088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3088" + term_id: C3088 + term_version: 20.05a + +hemangioendothelioma_benign: + common: + description: >- + A benign vascular proliferation characterized by the presence of prominent endothelial + cells and the formation of vascular channels. + termDef: + term: >- + Benign Hemangioendothelioma + source: NCIt + cde_id: C66779 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66779" + term_id: C66779 + term_version: 20.05a + +hemangioendothelioma_malignant: + common: + description: >- + A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, + it is characterized by frequently open vascular anastomosing and branching channels. The + malignant cells that line the vascular channels are spindle or epithelioid and + often display hyperchromatic nuclei. Angiosarcomas most frequently occur in + the skin and breast. Patients with long-standing lymphedema are at increased + risk of developing angiosarcoma. + termDef: + term: >- + Angiosarcoma + source: NCIt + cde_id: C3088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3088" + term_id: C3088 + term_version: 20.05a + +hemangioendothelioma_nos: + common: + description: >- + A vascular proliferation characterized by the presence of prominent endothelial + cells and the formation of vascular channels. Hemangioendotheliomas may display + borderline or low grade characteristics. + termDef: + term: >- + Hemangioendothelioma + source: NCIt + cde_id: C3084 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3084" + term_id: C3084 + term_version: 20.05a + +hemangioma_nos: + common: + description: >- + A benign vascular lesion characterized by the formation of capillary-sized or + cavernous vascular channels. + termDef: + term: >- + Hemangioma + source: NCIt + cde_id: C3085 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3085" + term_id: C3085 + term_version: 20.05a + +hemangioma_simplex: + common: + description: >- + A capillary hemangioma that may regress spontaneously. It occurs in infants + and children. + termDef: + term: >- + Infantile Hemangioma + source: NCIt + cde_id: C6645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6645" + term_id: C6645 + term_version: 20.05a + +hemangiopericytoma_benign: + common: + description: >- + A hemangiopericytoma without malignant morphologic or clinical characteristics. + termDef: + term: >- + Benign Hemangiopericytoma + source: NCIt + cde_id: C4300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4300" + term_id: C4300 + term_version: 20.05a + +hemangiopericytoma_malignant: + common: + description: >- + An uncommon malignant neoplasm arising from pericytes. Distinction between + benign and malignant hemangiopericytoma may be difficult or even impossible + on morphologic grounds alone. + termDef: + term: >- + Malignant Hemangiopericytoma + source: NCIt + cde_id: C4301 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4301" + term_id: C4301 + term_version: 20.05a + +hemangiopericytoma_nos: + common: + description: >- + An antiquated term that refers to benign or malignant mesenchymal neoplasms + characterized by the presence of neoplastic spindle-shaped to round cells arranged + around thin-walled branching vascular spaces. + termDef: + term: >- + Hemangiopericytoma + source: NCIt + cde_id: C3087 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3087" + term_id: C3087 + term_version: 20.05a + +hematocrit: + common: + description: >- + A measure of the volume of red blood cells expressed as a percentage of the + total blood volume. Normal in males is 43-49%, in females 37-43%. + termDef: + term: >- + Hematocrit Measurement + source: NCIt + cde_id: C64796 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64796" + term_id: C64796 + term_version: 20.10d + +hematologic_cancer: + common: + description: >- + A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral + blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic + cell neoplasms can also involve other anatomic sites (e.g. central nervous system, + gastrointestinal tract), either by metastasis, direct tumor infiltration, or + neoplastic transformation of extranodal lymphoid tissues. The commonest forms + are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative + neoplasms, and myelodysplastic syndromes. + termDef: + term: >- + Hematopoietic and Lymphoid Cell Neoplasm + source: NCIt + cde_id: C27134 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27134" + term_id: C27134 + term_version: 19.12e + +hematopoietic_system_nos: + common: + description: >- + The bodily system of organs and tissues, primarily the bone marrow, spleen, + tonsils, and lymph nodes, involved in the production of blood. + termDef: + term: >- + Hematopoietic System + source: NCIt + cde_id: C12909 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12909" + term_id: C12909 + term_version: 20.05a + +hemizygous: + common: + description: >- + Having only one copy of a particular gene or genetic region. + termDef: + term: >- + Hemizygosity + source: NCIt + cde_id: C64346 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64346" + term_id: C64346 + term_version: 20.10d + +hemoglobin: + common: + description: >- + A quantitative measurement of the amount of hemoglobin present in a biospecimen. + termDef: + term: >- + Hemoglobin Measurement + source: NCIt + cde_id: C64848 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64848" + term_id: C64848 + term_version: 20.10d + +hemolymphangioma: + common: + description: >- + A hemorrhagic lymphatic lesion characterized by the presence of dilated lymphatic + spaces, extravasation of red blood cells, hemosiderin deposition, and fibrosis. + termDef: + term: >- + Hemolymphangioma + source: NCIt + cde_id: C66792 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66792" + term_id: C66792 + term_version: 20.05a + +hepatic_flexure_of_colon: + common: + description: >- + The bend of the colon at the juncture of its ascending and transverse portions. + termDef: + term: >- + Hepatic Flexure + source: NCIt + cde_id: C12266 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12266" + term_id: C12266 + term_version: 20.05a + +hepatoblastoma: + common: + description: >- + A malignant liver neoplasm that occurs almost exclusively in infants, although + isolated cases in older children and adults have been reported. Grossly, hepatoblastoma + is solid, well circumscribed, and more often solitary than multiple. Microscopically, + most of the tumors are composed exclusively of immature hepatocytic elements. + About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated + or develop into bone or cartilage. The treatment of choice for hepatoblastoma + is surgical excision with adjuvant therapy. Liver transplantation is being increasingly + used as well. + termDef: + term: >- + Hepatoblastoma + source: NCIt + cde_id: C3728 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3728" + term_id: C3728 + term_version: 20.05a + +hepatoblastoma_mixed_epithelialmesenchymal: + common: + description: >- + A hepatoblastoma characterized by the presence of fetal and embryonal epithelial + components and a mesenchymal component. + termDef: + term: >- + Mixed Epithelial and Mesenchymal Hepatoblastoma + source: NCIt + cde_id: C7097 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7097" + term_id: C7097 + term_version: 20.05a + +hepatocarcinoma: + common: + description: >- + A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is + relatively rare in the United States but very common in all African countries + south of the Sahara and in Southeast Asia. Most cases are seen in patients over + the age of 50 years, but this tumor can also occur in younger individuals and + even in children. Hepatocellular carcinoma is more common in males than females + and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. + Serum elevation of alpha-fetoprotein occurs in a large percentage of patients + with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present + as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, + there is a wide range of differentiation from tumor to tumor (well differentiated + to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize + to regional lymph nodes and lung. The overall median survival of untreated liver + cell carcinoma is about 4 months. The most effective treatment of hepatocellular + carcinoma is complete resection of the tumor. Lately, an increasing number of + tumors have been treated with liver transplantation. + termDef: + term: >- + Hepatocellular Carcinoma + source: NCIt + cde_id: C3099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3099" + term_id: C3099 + term_version: 20.05a + +hepatocellular_adenoma: + common: + description: >- + A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears + as a soft, round mass which often contains areas of hemorrhage and necrosis. + Morphologically, the neoplastic cells resemble normal hepatocytes and form plates + separated by sinusoids. Most patients have a history of contraceptive or anabolic + steroids use. + termDef: + term: >- + Hepatocellular Adenoma + source: NCIt + cde_id: C3758 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3758" + term_id: C3758 + term_version: 20.05a + +hepatocellular_carcinoma_fibrolamellar: + common: + description: >- + A distinctive type of liver cell carcinoma that arises in non-cirrhotic livers + and is seen predominantly in young patients. The tumor cells are polygonal + and deeply eosinophilic, and are embedded in a fibrous stroma. The prognosis + is similar to classical hepatocellular carcinoma that arises in non-cirrhotic + livers, and better than hepatocellular carcinoma that arises in cirrhotic livers. + termDef: + term: >- + Fibrolamellar Carcinoma + source: NCIt + cde_id: C4131 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4131" + term_id: C4131 + term_version: 20.05a + +hepatocellular_carcinoma_nos: + common: + description: >- + A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is + relatively rare in the United States but very common in all African countries + south of the Sahara and in Southeast Asia. Most cases are seen in patients over + the age of 50 years, but this tumor can also occur in younger individuals and + even in children. Hepatocellular carcinoma is more common in males than females + and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. + Serum elevation of alpha-fetoprotein occurs in a large percentage of patients + with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present + as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, + there is a wide range of differentiation from tumor to tumor (well differentiated + to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize + to regional lymph nodes and lung. The overall median survival of untreated liver + cell carcinoma is about 4 months. The most effective treatment of hepatocellular + carcinoma is complete resection of the tumor. Lately, an increasing number of + tumors have been treated with liver transplantation. + termDef: + term: >- + Hepatocellular Carcinoma + source: NCIt + cde_id: C3099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3099" + term_id: C3099 + term_version: 20.05a + +hepatocellular_carcinoma_scirrhous: + common: + description: >- + An uncommon type of hepatocelluar carcinoma, morphologically characterized by + significant fibrosis around the sinusoid-like spaces and atrophy of the tumor + trabeculae. + termDef: + term: >- + Scirrhous Hepatocellular Carcinoma + source: NCIt + cde_id: C27388 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27388" + term_id: C27388 + term_version: 20.05a + +hepatocholangiocarcinoma: + common: + description: >- + A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma + that are intimately admixed. This tumor should be distinguished from separate + hepatocellular carcinoma and cholangiocarcinoma arising in the same liver. The + prognosis of this tumor is poor. + termDef: + term: >- + Combined Hepatocellular Carcinoma and Cholangiocarcinoma + source: NCIt + cde_id: C3828 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3828" + term_id: C3828 + term_version: 20.05a + +hepatoid_adenocarcinoma: + common: + description: >- + An adenocarcinoma with morphologic characteristics similar to hepatocellular + carcinoma, arising from an anatomic site other than the liver. + termDef: + term: >- + Hepatoid Adenocarcinoma + source: NCIt + cde_id: C66950 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66950" + term_id: C66950 + term_version: 20.05a + +hepatoid_carcinoma: + common: + description: >- + An adenocarcinoma with morphologic characteristics similar to hepatocellular + carcinoma, arising from an anatomic site other than the liver. + termDef: + term: >- + Hepatoid Adenocarcinoma + source: NCIt + cde_id: C66950 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66950" + term_id: C66950 + term_version: 20.05a + +hepatoid_yolk_sac_tumor: + common: + description: >- + A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It + is the most common malignant germ cell tumor in the pediatric population. It + occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, + abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor + mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment + includes: surgical resection, radiation, and chemotherapy. This tumor is very + responsive to chemotherapy regimens that include cisplatinum. + termDef: + term: >- + Yolk Sac Tumor + source: NCIt + cde_id: C3011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3011" + term_id: C3011 + term_version: 20.05a + +hepatoma_benign: + common: + description: >- + A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears + as a soft, round mass which often contains areas of hemorrhage and necrosis. + Morphologically, the neoplastic cells resemble normal hepatocytes and form plates + separated by sinusoids. Most patients have a history of contraceptive or anabolic + steroids use. + termDef: + term: >- + Hepatocellular Adenoma + source: NCIt + cde_id: C3758 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3758" + term_id: C3758 + term_version: 20.05a + +hepatoma_malignant: + common: + description: >- + A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is + relatively rare in the United States but very common in all African countries + south of the Sahara and in Southeast Asia. Most cases are seen in patients over + the age of 50 years, but this tumor can also occur in younger individuals and + even in children. Hepatocellular carcinoma is more common in males than females + and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. + Serum elevation of alpha-fetoprotein occurs in a large percentage of patients + with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present + as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, + there is a wide range of differentiation from tumor to tumor (well differentiated + to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize + to regional lymph nodes and lung. The overall median survival of untreated liver + cell carcinoma is about 4 months. The most effective treatment of hepatocellular + carcinoma is complete resection of the tumor. Lately, an increasing number of + tumors have been treated with liver transplantation. + termDef: + term: >- + Hepatocellular Carcinoma + source: NCIt + cde_id: C3099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3099" + term_id: C3099 + term_version: 20.05a + +hepatoma_nos: + common: + description: >- + A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is + relatively rare in the United States but very common in all African countries + south of the Sahara and in Southeast Asia. Most cases are seen in patients over + the age of 50 years, but this tumor can also occur in younger individuals and + even in children. Hepatocellular carcinoma is more common in males than females + and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. + Serum elevation of alpha-fetoprotein occurs in a large percentage of patients + with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present + as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, + there is a wide range of differentiation from tumor to tumor (well differentiated + to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize + to regional lymph nodes and lung. The overall median survival of untreated liver + cell carcinoma is about 4 months. The most effective treatment of hepatocellular + carcinoma is complete resection of the tumor. Lately, an increasing number of + tumors have been treated with liver transplantation. + termDef: + term: >- + Hepatocellular Carcinoma + source: NCIt + cde_id: C3099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3099" + term_id: C3099 + term_version: 20.05a + +hepatosplenic_gammadelta_cell_lymphoma: + common: + description: >- + An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic + T-cells, usually of gamma/delta T-cell type. It is characterized by the presence + of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A + similar infiltrating pattern is also present in the spleen and bone marrow that + are usually involved at the time of the diagnosis. + termDef: + term: >- + Hepatosplenic T-Cell Lymphoma + source: NCIt + cde_id: C8459 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8459" + term_id: C8459 + term_version: 20.05a + +hepatosplenic_tcell_lymphoma: + common: + description: >- + An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic + T-cells, usually of gamma/delta T-cell type. It is characterized by the presence + of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A + similar infiltrating pattern is also present in the spleen and bone marrow that + are usually involved at the time of the diagnosis. + termDef: + term: >- + Hepatosplenic T-Cell Lymphoma + source: NCIt + cde_id: C8459 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8459" + term_id: C8459 + term_version: 20.05a + +her2_inhibitor_dzd1516: + common: + description: >- + An orally bioavailable, blood brain barrier (BBB) penetrable inhibitor of the + receptor tyrosine kinase human epidermal growth factor receptor 2 (HER2; ErbB2; + HER-2), with potential antineoplastic activity. Upon oral administration, HER2 + inhibitor DZD1516 selectively binds to and inhibits the activity of HER2. This + prevents HER2-mediated signaling and leads to cell death in HER2-expressing + tumor cells. HER2, a receptor tyrosine kinase overexpressed on a variety of + tumor cell types, plays an important role in tumor cell proliferation and tumor + vascularization. + termDef: + term: >- + HER2 Inhibitor DZD1516 + source: NCIt + cde_id: C174039 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174039" + term_id: C174039 + term_version: 20.10d + +her2_trispecific_natural_killer_cell_engager_df1001: + common: + description: >- + An engineered molecule based on tri-specific natural killer (NK) cell engager + therapies (TriNKET) that is directed against human epidermal growth factor receptor + 2 (EGFR2; HER2; ErbB2), with potential immunostimulating and antineoplastic + activities. Upon administration, HER2 tri-specific NK cell engager DF1001 targets + and binds to HER2 on tumor cells and simultaneously binds to NK cells, thereby + bringing HER2-expressing tumor cells and NK cells together, which stimulates + the NK cells and results in the selective NK cell-mediated tumor cell lysis + of HER2-expressing tumor cells. The binding of HER2-expressing tumor cells and + NK cells may also lead to the activation of T-cells and B-cells, potentiating + the immune response against HER2-expressing tumor cells. HER2, a receptor tyrosine + kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key + role in tumor cell proliferation and tumor vascularization. + termDef: + term: >- + HER2 Tri-specific Natural Killer Cell Engager DF1001 + source: NCIt + cde_id: C172279 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172279" + term_id: C172279 + term_version: 20.10d + +her2directed_tlr8_agonist_sbt6050: + common: + description: >- + An immunotherapeutic composed of a monoclonal antibody directed against the + tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2; + HER2; ErbB2) conjugated to a Toll-like receptor 8 (TLR8; CD288) agonist, with + potential immunostimulating and antineoplastic activities. Upon intravenous + administration of the HER2-directed TLR8 agonist SBT6050, the anti-HER2 monoclonal + antibody targets and binds to HER2 expressed on tumor cells, thereby localizing + the TLR8 agonist directly to the tumor site. In turn, the TLR8 agonist moiety + binds to TLR8 expressed on myeloid cells within the tumor microenvironment (TME). + This activates myeloid cells, including tumor-associated macrophages (TAMs), + myeloid cell-derived suppressive cells (MDSCs), and conventional dendritic cells + (cDCs). This may lead to the activation of nuclear factor NF-kappa-B, the production + of pro-inflammatory cytokines and chemokines, macrophage-induced tumor cell + killing, inflammasome activation, activation of cytolytic natural killer (NK) + cells and neutrophils, and the induction of a Th1-weighted anti-tumor immune + response. It also reverses the suppression of senescent naive and tumor-specific + T-cells, and enhances the anti-tumor cytotoxic T-lymphocyte (CTL) immune response. + TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) + and plays a key role in innate and adaptive immunity. HER2, a tyrosine kinase + receptor, is overexpressed by many cancer cell types. + termDef: + term: >- + HER2-directed TLR8 Agonist SBT6050 + source: NCIt + cde_id: C174010 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174010" + term_id: C174010 + term_version: 20.10d + +hereditary_leiomyomatosis__rccassociated_renal_cell_carcinoma: + common: + description: >- + An autosomal dominant inherited syndrome caused by germline mutations in the + FH gene. It is characterized by predisposition to renal cell carcinoma, leiomyomas + of the skin and uterus, and leiomyosarcoma of the uterus. + termDef: + term: >- + Hereditary Leiomyomatosis and Renal Cell Carcinoma + source: NCIt + cde_id: C51302 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51302" + term_id: C51302 + term_version: 20.05a + +herpud1: + common: + description: >- + This gene is involved in the response to endoplasmic reticulum stress. + termDef: + term: >- + HERPUD1 Gene + source: NCIt + cde_id: C97534 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97534" + term_id: C97534 + term_version: 20.10d + +heterozygous: + common: + description: >- + Having two different allelic forms of a gene, one inherited from each parent, + on each of the two homologous chromosomes. + termDef: + term: >- + Heterozygosity + source: NCIt + cde_id: C45825 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45825" + term_id: C45825 + term_version: 20.10d + +hey1: + common: + description: >- + This gene is involved in both transcription factor binding and transcriptional + repression. + termDef: + term: >- + HEY1 Gene + source: NCIt + cde_id: C101107 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101107" + term_id: C101107 + term_version: 20.10d + +hibernoma: + common: + description: >- + A rare benign slow growing adipose tissue tumor, characterized by the presence + of polygonal brown fat cells with multivacuolated and/or granular cytoplasm. The + tumor is usually painless and is most often seen in young adults. + termDef: + term: >- + Hibernoma + source: NCIt + cde_id: C3702 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3702" + term_id: C3702 + term_version: 20.05a + +hidradenocarcinoma: + common: + description: >- + A carcinoma with apocrine and less often eccrine differentiation, arising from + the sweat glands. It usually presents as a solitary slow growing nodule in the + dermis or subcutaneous tissues. It is characterized by a nodular growth pattern + and it is often associated with necrotic changes. + termDef: + term: >- + Hidradenocarcinoma + source: NCIt + cde_id: C54664 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54664" + term_id: C54664 + term_version: 20.05a + +hidradenoma_nos: + common: + description: >- + A benign epithelial neoplasm arising from the sweat glands. Variants include + the clear cell and nodular hidradenoma. + termDef: + term: >- + Hidradenoma + source: NCIt + cde_id: C7563 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7563" + term_id: C7563 + term_version: 20.05a + +hidradenoma_papilliferum: + common: + description: >- + A benign neoplasm arising from the sweat glands. It presents as a slow growing + cystic nodular lesion most often in the skin of the vulva and the perianal region. + It is characterized by the presence of cystic and large papillary structures. + The papillary structures contain connective tissue and are covered by two layers + of epithelium. Complete excision is curative. + termDef: + term: >- + Hidradenoma Papilliferum + source: NCIt + cde_id: C4171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4171" + term_id: C4171 + term_version: 20.05a + +hidrocystoma: + common: + description: >- + A benign cystic proliferation of the sweat glands with apocrine or eccrine differentiation. + It usually presents as a dome-shaped, cystic papular or nodular lesion usually + in the face and neck. It is a unilocular or mutlilocular lesion lined by an + inner and an outer layer of epithelium. Complete excision is usually curative. + termDef: + term: >- + Hidrocystoma + source: NCIt + cde_id: C3760 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3760" + term_id: C3760 + term_version: 20.05a + +hif1a: + common: + description: >- + This gene plays a role in cardiovascular development and systemic oxygen homeostasis. + termDef: + term: >- + HIF1A Gene + source: NCIt + cde_id: C26372 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26372" + term_id: C26372 + term_version: 20.10d + +hif2a_rnai_arohif2: + common: + description: >- + An RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), + with potential antineoplastic activity. Upon administration of HIF2a RNAi ARO-HIF2, + the agent binds to and neutralizes mRNA HIF2a, thereby preventing the production + of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, + overexpressed in certain cell types, plays a key role in proliferation, progression + and metastasis of tumors. + termDef: + term: >- + HIF2a RNAi ARO-HIF2 + source: NCIt + cde_id: C170918 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170918" + term_id: C170918 + term_version: 20.10d + +high: + common: + description: >- + An elevated level or position or degree; greater than normal in degree or intensity + or amount. + termDef: + term: >- + High + source: NCIt + cde_id: C25227 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25227" + term_id: C25227 + term_version: 20.05a + +high_grade: + common: + description: >- + Used to describe tumor samples that exhibit poorly differentiated or undifferentiated + cells. They are generally expected to be fast growing and aggressive. + termDef: + term: >- + High Grade + source: NCIt + cde_id: C14158 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C14158" + term_id: C14158 + term_version: 20.05a + pathology_detail: + dysplasia_degree: + description: >- + A subjective characterization of the phenomenon of dysplasia, based on microscopic + examination of the architectural and/or cytological changes in a tissue sample, + that is determined to be high. + termDef: + term: >- + High Grade Dysplasia + source: NCIt + cde_id: C156083 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156083" + term_id: C156083 + term_version: 20.10d + +high_grade_dysplasia: + common: + description: >- + A subjective characterization of the phenomenon of dysplasia, based on microscopic + examination of the architectural and/or cytological changes in a tissue sample, + that is determined to be high. + termDef: + term: >- + High Grade Dysplasia + source: NCIt + cde_id: C156083 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156083" + term_id: C156083 + term_version: 20.05a + +high_grade_g2: + common: + description: >- + A high-grade lesion, corresponding to Broder's Grades 3 and 4, having a higher + incidence of metastasis and characterized histologically by mitotic figures, + prominent nucleoli, and pleomorphism. + termDef: + term: >- + Enneking High Surgical Grade + source: NCIt + cde_id: C140261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140261" + term_id: C140261 + term_version: 20.05a + +high_grade_surface_osteosarcoma: + common: + description: >- + A usually aggressive high grade malignant bone-forming mesenchymal neoplasm + arising from the surface of the bone. + termDef: + term: >- + High Grade Surface Osteosarcoma + source: NCIt + cde_id: C53958 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53958" + term_id: C53958 + term_version: 20.05a + +high_risk: + diagnosis: + international_prognostic_index: + description: >- + A risk group associated with a total score of 4 or 5 on the International + Prognostic Index indicating that an individual has a 5 year survival prognosis + of 32%. + termDef: + term: >- + International Prognostic Index High Risk Group + source: NCIt + cde_id: C161809 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C161809" + term_id: C161809 + term_version: 20.05a + common: + description: >- + The potential future harm that may arise from some present action or attribute + or condition is almost certain. + termDef: + term: >- + High Risk + source: NCIt + cde_id: C102401 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102401" + term_id: C102401 + term_version: 20.05a + +highintermediate_risk: + common: + description: >- + A risk group associated with a total score of 3 on the International Prognostic + Index indicating that an individual has a 5 year survival prognosis of 46%. + termDef: + term: >- + International Prognostic Index High-Intermediate Risk Group + source: NCIt + cde_id: C161808 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C161808" + term_id: C161808 + term_version: 20.05a + +hilar: + common: + description: >- + A lymph node located in the area around the hilum. + termDef: + term: >- + Perihilar Lymph Node + source: NCIt + cde_id: C102330 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102330" + term_id: C102330 + term_version: 20.10d + +hilar_cell_tumor: + common: + description: >- + A benign Leydig cell tumor which arises in the hilar area of the ovary. + termDef: + term: >- + Ovarian Hilus Cell Tumor + source: NCIt + cde_id: C4214 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4214" + term_id: C4214 + term_version: 20.05a + +hilus_cell_tumor: + common: + description: >- + A benign Leydig cell tumor which arises in the hilar area of the ovary. + termDef: + term: >- + Ovarian Hilus Cell Tumor + source: NCIt + cde_id: C4214 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4214" + term_id: C4214 + term_version: 20.05a + +hip1: + common: + description: >- + This gene plays a role in both vesicle coat formation and endocytosis. + termDef: + term: >- + HIP1 Gene + source: NCIt + cde_id: C97537 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97537" + term_id: C97537 + term_version: 20.10d + +hispanic_or_latino: + common: + description: >- + A person of Cuban, Mexican, Puerto Rican, South or Central American, or other + Spanish culture or origin, regardless of race. The term, "Spanish origin," can + be used in addition to "Hispanic or Latino." (OMB) + termDef: + term: >- + Hispanic or Latino + source: NCIt + cde_id: C17459 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17459" + term_id: C17459 + term_version: 19.12e + +hist1h3b: + common: + description: >- + This gene is involved in chromatin structure. + termDef: + term: >- + HIST1H3B Gene + source: NCIt + cde_id: C101732 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101732" + term_id: C101732 + term_version: 20.10d + +hist1h4i: + common: + description: >- + This gene plays a role in nucleosomal structure. + termDef: + term: >- + HIST1H4I Gene + source: NCIt + cde_id: C68734 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68734" + term_id: C68734 + term_version: 20.10d + +histiocyterich_large_bcell_lymphoma: + common: + description: >- + A large B-cell lymphoma characterized by the presence of a limited number of + scattered neoplastic large B-lymphocytes which are admixed with numerous non-neoplastic + T-lymphocytes and frequently histiocytes. + termDef: + term: >- + T-Cell/Histiocyte-Rich Large B-Cell Lymphoma + source: NCIt + cde_id: C9496 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9496" + term_id: C9496 + term_version: 20.05a + +histiocytic_medullary_reticulosis: + common: + description: >- + An antiquated term referring to cases of systemic non-Hodgkin lymphomas which + are composed of large, atypical neoplastic lymphoid cells and cases of hemophagocytic + syndromes. In the past, cases of anaplastic large cells lymphoma were called + malignant histiocytosis. + termDef: + term: >- + Malignant Histiocytosis + source: NCIt + cde_id: C7202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7202" + term_id: C7202 + term_version: 20.05a + +histiocytic_sarcoma: + common: + description: >- + An aggressive malignant neoplasm with a poor response to therapy, usually presenting + as stage III/IV disease. It is characterized by the presence of neoplastic cells + with morphologic and immunophenotypic characteristics similar to those seen + in mature histiocytes. + termDef: + term: >- + Histiocytic Sarcoma + source: NCIt + cde_id: C27349 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27349" + term_id: C27349 + term_version: 20.05a + +histiocytoid_hemangioma: + common: + description: >- + A hemangioma characterized by the presence of epithelioid endothelial cells. + termDef: + term: >- + Epithelioid Hemangioma + source: NCIt + cde_id: C4298 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4298" + term_id: C4298 + term_version: 20.05a + +histiocytoma_nos: + common: + description: >- + A mesenchymal tumor composed of fibroblastic and histiocytic cells. + termDef: + term: >- + Histiocytoma + source: NCIt + cde_id: C35765 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35765" + term_id: C35765 + term_version: 20.05a + +histiocytosis_x_nos: + common: + description: >- + A neoplastic proliferation of Langerhans cells which contain Birbeck granules + by ultrastructural examination. Three major overlapping syndromes are recognized: + eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. + The clinical course is generally related to the number of organs affected at + presentation. (WHO, 2001) + termDef: + term: >- + Langerhans Cell Histiocytosis + source: NCIt + cde_id: C3107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3107" + term_id: C3107 + term_version: 20.05a + +hlaa: + common: + description: >- + This gene is involved in immune responses and histocompatibility processes. + termDef: + term: >- + HLA-A Gene + source: NCIt + cde_id: C28585 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28585" + term_id: C28585 + term_version: 20.10d + +hladr: + common: + description: >- + Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region + of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility + transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, + 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens + function in antigen presentation to regulatory T cells in the immune response + and in self/nonself discrimination. Invariant alpha and polymorphic beta chains + have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. + The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic + N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 + contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences + have relatively simple structure; beta chains carry the major polymorphic determinants. + termDef: + term: >- + HLA-DR Antigen + source: NCIt + cde_id: C16692 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16692" + term_id: C16692 + term_version: 20.10d + +hlf: + common: + description: >- + This gene is involved in both transcriptional regulation and DNA binding. + termDef: + term: >- + HLF Gene + source: NCIt + cde_id: C97556 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97556" + term_id: C97556 + term_version: 20.10d + +hmga1: + common: + description: >- + This gene plays a role in a number of cellular processes including apoptosis, + chromatin organization and transcriptional regulation. + termDef: + term: >- + HMGA1 Gene + source: NCIt + cde_id: C20576 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20576" + term_id: C20576 + term_version: 20.10d + +hmga2: + common: + description: >- + This gene is involved in chromatin organization and regulation of gene transcription. + It also plays a role in development. + termDef: + term: >- + HMGA2 Gene + source: NCIt + cde_id: C20577 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20577" + term_id: C20577 + term_version: 20.10d + +hmgn2p46: + common: + description: >- + This gene may be involved in prostate functions. + termDef: + term: >- + HMGN2P46 Gene + source: NCIt + cde_id: C98093 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98093" + term_id: C98093 + term_version: 20.10d + +hnf1a: + common: + description: >- + This gene plays a role in both DNA binding and transcriptional modulation. + termDef: + term: >- + HNF1A Gene + source: NCIt + cde_id: C97825 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97825" + term_id: C97825 + term_version: 20.10d + +hnrnpa2b1: + common: + description: >- + This gene is involved in RNA processing and transport. + termDef: + term: >- + HNRNPA2B1 Gene + source: NCIt + cde_id: C97496 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97496" + term_id: C97496 + term_version: 20.10d + +hodgkin_disease_lymphocyte_predominance_diffuse: + common: + description: >- + A subtype of classic Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg + cells and a nodular or less often diffuse cellular background consisting of + small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, + 2008) + termDef: + term: >- + Lymphocyte-Rich Classic Hodgkin Lymphoma + source: NCIt + cde_id: C6913 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6913" + term_id: C6913 + term_version: 20.05a + +hodgkin_disease_lymphocyte_predominance_nos: + common: + description: >- + An antiquated term that refers either to nodular lymphocyte predominant Hodgkin + lymphoma or to lymphocyte-rich classical Hodgkin lymphoma. + termDef: + term: >- + Lymphocyte Predominant Type Hodgkin's Disease + source: NCIt + cde_id: C8590 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8590" + term_id: C8590 + term_version: 20.05a + +hodgkin_disease_lymphocytichistiocytic_predominance: + common: + description: >- + An antiquated term that refers either to nodular lymphocyte predominant Hodgkin + lymphoma or to lymphocyte-rich classical Hodgkin lymphoma. + termDef: + term: >- + Lymphocyte Predominant Type Hodgkin's Disease + source: NCIt + cde_id: C8590 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8590" + term_id: C8590 + term_version: 20.05a + +hodgkin_disease_nodular_sclerosis_lymphocyte_depletion: + common: + description: >- + Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Depletion + termDef: + term: >- + Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Depletion + source: NCIt + cde_id: C27808 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27808" + term_id: C27808 + term_version: 20.05a + +hodgkin_disease_nodular_sclerosis_lymphocyte_predominance: + common: + description: >- + Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Predominance + termDef: + term: >- + Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Predominance + source: NCIt + cde_id: C27270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27270" + term_id: C27270 + term_version: 20.05a + +hodgkin_disease_nodular_sclerosis_mixed_cellularity: + common: + description: >- + Hodgkin's Disease, Nodular Sclerosis, Mixed Cellularity + termDef: + term: >- + Hodgkin's Disease, Nodular Sclerosis, Mixed Cellularity + source: NCIt + cde_id: C27098 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27098" + term_id: C27098 + term_version: 20.05a + +hodgkin_disease_nodular_sclerosis_nos: + common: + description: >- + A subtype of classic Hodgkin lymphoma characterized by collagen bands that surround + at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type + morphology. (WHO, 2008) + termDef: + term: >- + Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: C3518 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3518" + term_id: C3518 + term_version: 20.05a + +hodgkin_disease_nodular_sclerosis_syncytial_variant: + common: + description: >- + Nodular Sclerosis Classic Hodgkin Lymphoma, Syncytial Variant + termDef: + term: >- + Nodular Sclerosis Classic Hodgkin Lymphoma, Syncytial Variant + source: NCIt + cde_id: C27807 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27807" + term_id: C27807 + term_version: 20.05a + +hodgkin_disease_nos: + common: + description: >- + A lymphoma, previously known as Hodgkin's disease, characterized by the presence + of large tumor cells in an abundant admixture of nonneoplastic cells. There + are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and + classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. + termDef: + term: >- + Hodgkin Lymphoma + source: NCIt + cde_id: C9357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9357" + term_id: C9357 + term_version: 20.05a + +hodgkin_granuloma: + common: + description: >- + An obsolete term that refers to cases of Hodgkin lymphoma excluding cases that + were classified as Hodgkin's paragranuloma and Hodgkin's sarcoma. + termDef: + term: >- + Hodgkin's Granuloma + source: NCIt + cde_id: C6914 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6914" + term_id: C6914 + term_version: 20.05a + +hodgkin_lymphoma_lymphocyte_depletion_nos: + common: + description: >- + A diffuse subtype of classic Hodgkin lymphoma which is rich in Hodgkin and Reed-Sternberg + cells and/or depleted in non-neoplastic lymphocytes. (WHO, 2008) + termDef: + term: >- + Lymphocyte-Depleted Classic Hodgkin Lymphoma + source: NCIt + cde_id: C9283 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9283" + term_id: C9283 + term_version: 20.05a + +hodgkin_lymphoma_lymphocyte_predominance_nodular: + common: + description: >- + A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse + proliferation of scattered large neoplastic cells known as popcorn or lymphocyte + predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or + histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in + nearly all instances. Patients are predominantly male, frequently in the 30-50 + year age group. Most patients present with limited stage disease (localized + peripheral lymphadenopathy, stage I or II). (WHO 2008) + termDef: + term: >- + Nodular Lymphocyte Predominant Hodgkin Lymphoma + source: NCIt + cde_id: C7258 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7258" + term_id: C7258 + term_version: 20.05a + +hodgkin_lymphoma_lymphocyterich: + common: + description: >- + A subtype of classic Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg + cells and a nodular or less often diffuse cellular background consisting of + small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, + 2008) + termDef: + term: >- + Lymphocyte-Rich Classic Hodgkin Lymphoma + source: NCIt + cde_id: C6913 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6913" + term_id: C6913 + term_version: 20.05a + +hodgkin_lymphoma_mixed_cellularity_nos: + common: + description: >- + A subtype of classic Hodgkin lymphoma with scattered Reed-Sternberg and Hodgkin + cells in a diffuse or vaguely nodular mixed inflammatory background without + nodular sclerosing fibrosis. (WHO, 2008) + termDef: + term: >- + Mixed Cellularity Classic Hodgkin Lymphoma + source: NCIt + cde_id: C3517 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3517" + term_id: C3517 + term_version: 20.05a + +hodgkin_lymphoma_nodular_lymphocyte_predominance: + common: + description: >- + A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse + proliferation of scattered large neoplastic cells known as popcorn or lymphocyte + predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or + histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in + nearly all instances. Patients are predominantly male, frequently in the 30-50 + year age group. Most patients present with limited stage disease (localized + peripheral lymphadenopathy, stage I or II). (WHO 2008) + termDef: + term: >- + Nodular Lymphocyte Predominant Hodgkin Lymphoma + source: NCIt + cde_id: C7258 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7258" + term_id: C7258 + term_version: 20.05a + +hodgkin_lymphoma_nodular_sclerosis_cellular_phase: + common: + description: >- + A nodular sclerosis Hodgkin lymphoma characterized by the presence of lacunar + cells, nodular growth, and the absence of fibrosis. + termDef: + term: >- + Nodular Sclerosis Classic Hodgkin Lymphoma, Cellular Phase + source: NCIt + cde_id: C67171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67171" + term_id: C67171 + term_version: 20.05a + +hodgkin_lymphoma_nodular_sclerosis_grade_1: + common: + description: >- + Nodular sclerosis Hodgkin lymphoma in which at least 75% of the tumor nodules + contain scattered Reed-Sternberg cells. The background cellular infiltrate is + lymphocytic, mixed, or fibrohistiocytic. + termDef: + term: >- + Grade 1 Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: C7165 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7165" + term_id: C7165 + term_version: 20.05a + +hodgkin_lymphoma_nodular_sclerosis_grade_2: + common: + description: >- + Nodular sclerosis Hodgkin lymphoma in which at least 25% of the tumor nodules + contain increased numbers of Reed-Sternberg cells. + termDef: + term: >- + Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: C7166 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7166" + term_id: C7166 + term_version: 20.05a + +hodgkin_lymphoma_nodular_sclerosis_nos: + common: + description: >- + A subtype of classic Hodgkin lymphoma characterized by collagen bands that surround + at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type + morphology. (WHO, 2008) + termDef: + term: >- + Nodular Sclerosis Classic Hodgkin Lymphoma + source: NCIt + cde_id: C3518 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3518" + term_id: C3518 + term_version: 20.05a + +hodgkin_lymphoma_nos: + common: + description: >- + A lymphoma, previously known as Hodgkin's disease, characterized by the presence + of large tumor cells in an abundant admixture of nonneoplastic cells. There + are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and + classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. + termDef: + term: >- + Hodgkin Lymphoma + source: NCIt + cde_id: C9357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9357" + term_id: C9357 + term_version: 20.05a + +hodgkin_paragranuloma_nodular: + common: + description: >- + An obsolete term that includes cases currently classified as nodular lymphocyte + predominant Hodgkin lymphoma. + termDef: + term: >- + Hodgkin's Paragranuloma + source: NCIt + cde_id: C26956 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26956" + term_id: C26956 + term_version: 20.05a + +hodgkin_paragranuloma_nos: + common: + description: >- + An obsolete term that includes cases currently classified as nodular lymphocyte + predominant Hodgkin lymphoma. + termDef: + term: >- + Hodgkin's Paragranuloma + source: NCIt + cde_id: C26956 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26956" + term_id: C26956 + term_version: 20.05a + +hodgkin_sarcoma: + common: + description: >- + A lymphoma, previously known as Hodgkin's disease, characterized by the presence + of large tumor cells in an abundant admixture of nonneoplastic cells. There + are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and + classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. + termDef: + term: >- + Hodgkin Lymphoma + source: NCIt + cde_id: C9357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9357" + term_id: C9357 + term_version: 20.05a + +holy_see: + common: + description: >- + An enclave of Rome (Italy). Vatican City State. + termDef: + term: >- + Holy See + source: NCIt + cde_id: C17249 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17249" + term_id: C17249 + term_version: 19.12e + +homozygous: + common: + description: >- + Having two identical allelic forms of a gene, one inherited from each parent, + on each of the two homologous chromosomes. + termDef: + term: >- + Homozygosity + source: NCIt + cde_id: C45826 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45826" + term_id: C45826 + term_version: 20.10d + +honduras: + common: + description: >- + A country in Central America, bordering the Caribbean Sea, between Guatemala + and Nicaragua. + termDef: + term: >- + Honduras + source: NCIt + cde_id: C16694 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16694" + term_id: C16694 + term_version: 19.12e + +hong_kong: + common: + description: >- + A special administrative region of China, bordering the South China Sea, east + of Macao. + termDef: + term: >- + Hong Kong + source: NCIt + cde_id: C16695 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16695" + term_id: C16695 + term_version: 19.12e + +hook3: + common: + description: >- + This gene plays a role in endocytosis and Golgi maintenance. + termDef: + term: >- + HOOK3 Gene + source: NCIt + cde_id: C97493 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97493" + term_id: C97493 + term_version: 20.10d + +hoxa11: + common: + description: >- + This gene is involved in embryologic pattern formation. + termDef: + term: >- + HOXA11 Gene + source: NCIt + cde_id: C97568 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97568" + term_id: C97568 + term_version: 20.10d + +hoxa13: + common: + description: >- + This gene plays a role in transcriptional modulation. + termDef: + term: >- + HOXA13 Gene + source: NCIt + cde_id: C97571 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97571" + term_id: C97571 + term_version: 20.10d + +hoxa9: + common: + description: >- + This gene plays a role in transcriptional regulation, morphogenesis and differentiation. + termDef: + term: >- + HOXA9 Gene + source: NCIt + cde_id: C24474 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24474" + term_id: C24474 + term_version: 20.10d + +hoxb1: + common: + description: >- + This gene is involved in the development of anterior embryonic structures and + facial nerves. + termDef: + term: >- + HOXB1 Gene + source: NCIt + cde_id: C162630 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C162630" + term_id: C162630 + term_version: 20.10d + +hoxc11: + common: + description: >- + This gene is involved in embryological development. + termDef: + term: >- + HOXC11 Gene + source: NCIt + cde_id: C97574 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97574" + term_id: C97574 + term_version: 20.10d + +hoxc13: + common: + description: >- + This gene plays a role in the modulation of transcription. + termDef: + term: >- + HOXC13 Gene + source: NCIt + cde_id: C97577 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97577" + term_id: C97577 + term_version: 20.10d + +hoxd11: + common: + description: >- + This gene is involved in limb morphogenesis. + termDef: + term: >- + HOXD11 Gene + source: NCIt + cde_id: C97580 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97580" + term_id: C97580 + term_version: 20.10d + +hoxd13: + common: + description: >- + This gene plays a role in the development of limbs and appendages. + termDef: + term: >- + HOXD13 Gene + source: NCIt + cde_id: C97583 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97583" + term_id: C97583 + term_version: 20.10d + +hpv_16_e6e7encoding_arenavirus_vaccine_hb202: + common: + description: >- + A cancer vaccine consisting of replication-attenuated arenavirus encoding the + inactivated fusion protein of the viral oncoproteins E6 and E7 derived from + the human papillomavirus (HPV) serotype 16, with potential immunomodulating + and antineoplastic activities. Upon administration, HPV 16 E6/E7-encoding arenavirus + vaccine HB-202 induces expression of the E6/E7 proteins and stimulates the host + immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor + cells expressing HPV16 E6 and E7, resulting in tumor cell lysis. Oncoproteins + E6 and E7 play a key role in the development of cervical intraepithelial neoplasia + (CIN) and cervical carcinoma. + termDef: + term: >- + HPV 16 E6/E7-encoding Arenavirus Vaccine HB-202 + source: NCIt + cde_id: C173149 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173149" + term_id: C173149 + term_version: 20.10d + +hpv_e6e7encoding_arenavirus_vaccine_hb201: + common: + description: >- + A cancer vaccine consisting of a replication-attenuated arenavirus lymphocytic + choriomeningitis virus (LCMV) encoding the inactivated fusion protein of the + viral oncoproteins E6 and E7 derived from the human papillomavirus (HPV) serotype + 16, with potential immunomodulating and antineoplastic activities. Upon administration, + HPV E6/E7-encoding arenavirus vaccine HB-201 induces expression of the E6/E7 + proteins and stimulates the host immune system to mount a cytotoxic T-lymphocyte + (CTL) response against tumor cells expressing HPV16 E6 and E7, resulting in + tumor cell lysis. Oncoproteins E6 and E7 play a key role in the development + of cervical intraepithelial neoplasia (CIN) and cervical carcinoma. + termDef: + term: >- + HPV E6/E7-encoding Arenavirus Vaccine HB-201 + source: NCIt + cde_id: C167349 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167349" + term_id: C167349 + term_version: 20.10d + +hpv611targeted_dna_plasmid_vaccine_ino3107: + common: + description: >- + A DNA vaccine consisting of plasmids encoding E6 and E7 genes of human papilloma + virus subtype 6 (HPV-6) and 11 (HPV-11), with potential immunostimulating and + antineoplastic activities. Upon administration via intramuscular electroporation, + the HPV-6/11-targeted DNA plasmid vaccine INO-3107 expresses the HPV-6/11 E6 + and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against + tumor cells that are expressing HPV6 and/or HPV11 E6 and E7 proteins, resulting + in tumor cell lysis. HPV-6/11 infections are associated with aerodigestive malignancies. + termDef: + term: >- + HPV6/11-targeted DNA Plasmid Vaccine INO-3107 + source: NCIt + cde_id: C173718 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173718" + term_id: C173718 + term_version: 20.10d + +hpve6e7: + common: + description: >- + The determination of the amount of the human papillomavirus transforming proteins + E6 and E7 present in a sample. + termDef: + term: >- + Human Papillomavirus E6/E7 Protein Measurement + source: NCIt + cde_id: C171144 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171144" + term_id: C171144 + term_version: 20.10d + +hras: + common: + description: >- + This gene plays a role in signal transduction and cellular communication. + termDef: + term: >- + HRAS Gene + source: NCIt + cde_id: C17060 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17060" + term_id: C17060 + term_version: 20.10d + +hsp90_inhibitor_tqb3474: + common: + description: >- + An inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic + activity. Upon administration, Hsp90 inhibitor TQB3474 specifically blocks Hsp90, + which inhibits its chaperone function and promotes the proteasomal degradation + of oncogenic signaling proteins involved in tumor cell proliferation and survival. + This may lead to an inhibition of tumor cell proliferation. Hsp90, a chaperone + complex protein upregulated in a variety of tumor cell types, regulates the + folding and degradation of many oncogenic signaling proteins. + termDef: + term: >- + Hsp90 Inhibitor TQB3474 + source: NCIt + cde_id: C173550 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173550" + term_id: C173550 + term_version: 20.10d + +hsp90aa1: + common: + description: >- + This gene is involved in both protein folding and nitric oxide metabolism. + termDef: + term: >- + HSP90AA1 Gene + source: NCIt + cde_id: C97586 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97586" + term_id: C97586 + term_version: 20.10d + +hsp90ab1: + common: + description: >- + This gene plays a role in both interferon signaling and protein folding. + termDef: + term: >- + HSP90AB1 Gene + source: NCIt + cde_id: C97589 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97589" + term_id: C97589 + term_version: 20.10d + +hsp90targeted_photosensitizer_hs201: + common: + description: >- + A conjugate consisting of a heat shock protein 90 (Hsp90) inhibitor connected + via a linker to verteporfin, a photosensitizing agent, with potential imaging, + photodynamic and antineoplastic activities. Upon administration, the Hsp90 inhibitor + moiety of HS-201 selectively binds to the Hsp90 ATP binding domain in tumor + cells and HS-201 accumulates in tumor cells. The verteporfin moiety of HS-201 + allows for visualization and photodynamic therapy of the tumors. Hsp90, a chaperone + protein upregulated in a variety of tumor cells, regulates the folding, stability + and degradation of many oncogenic signaling proteins. Verteporfin is a synthetic + photosensitizer with photodynamic activity. + termDef: + term: >- + Hsp90-targeted Photosensitizer HS-201 + source: NCIt + cde_id: C172190 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172190" + term_id: C172190 + term_version: 20.10d + +human_chorionic_gonadotropin: + common: + description: >- + The determination of the amount of choriogonadotropin present in a sample. + termDef: + term: >- + Choriogonadotropin Measurement + source: NCIt + cde_id: C147128 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C147128" + term_id: C147128 + term_version: 20.10d + +human_papillomavirus: + common: + description: >- + Any microbiologic test or molecular assay used to detect the presence of a human + papillomavirus in a sample. + termDef: + term: >- + Human Papillomavirus Test + source: NCIt + cde_id: C171145 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171145" + term_id: C171145 + term_version: 20.10d + +hungary: + common: + description: >- + A country in central Europe, northwest of Romania and south of Slovakia. + termDef: + term: >- + Hungary + source: NCIt + cde_id: C16699 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16699" + term_id: C16699 + term_version: 19.12e + +hurthle_cell_adenocarcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of large malignant epithelial + cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative + examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast + carcinoma, and salivary gland oncocytic carcinoma. + termDef: + term: >- + Oxyphilic Adenocarcinoma + source: NCIt + cde_id: C3679 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3679" + term_id: C3679 + term_version: 20.05a + +hurthle_cell_adenoma: + common: + description: >- + A thyroid gland adenoma composed of large cells with abundant granular eosinophilic + cytoplasm and large nuclei with prominent nucleoli. + termDef: + term: >- + Thyroid Gland Hurthle Cell Adenoma + source: NCIt + cde_id: C6042 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6042" + term_id: C6042 + term_version: 20.05a + +hurthle_cell_carcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of large malignant epithelial + cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative + examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast + carcinoma, and salivary gland oncocytic carcinoma. + termDef: + term: >- + Oxyphilic Adenocarcinoma + source: NCIt + cde_id: C3679 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3679" + term_id: C3679 + term_version: 20.05a + +hurthle_cell_tumor: + common: + description: >- + An adenoma or carcinoma arising from the follicular cells of the thyroid gland. It + is composed of large oncocytic cells with abundant granular eosinophilic cytoplasm. + termDef: + term: >- + Thyroid Gland Hurthle (Oncocytic) Cell Neoplasm + source: NCIt + cde_id: C46068 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46068" + term_id: C46068 + term_version: 20.05a + +husband: + common: + description: >- + A male partner in marriage. + termDef: + term: >- + Husband + source: NCIt + cde_id: C71588 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71588" + term_id: C71588 + term_version: 19.12e + +hutchinson_melanotic_freckle_nos: + common: + description: >- + An atypical proliferation of atypical melanocytes in the dermal-epidermal junction, + without infiltration of the papillary or reticular dermis. The melanocytic proliferation + is associated with actinic damage and epidermal atrophy. It usually occurs + in the sun-exposed skin of elderly people. It is a form of melanoma in situ. + termDef: + term: >- + Lentigo Maligna + source: NCIt + cde_id: C43372 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43372" + term_id: C43372 + term_version: 20.05a + +hyalinizing_trabecular_adenoma: + common: + description: >- + A rare, circumscribed or encapsulated tumor arising from the follicular cells + of the thyroid gland. It is characterized by a trabecular growth pattern and + hyalinized stroma formation. The vast majority of cases have a benign clinical + course. + termDef: + term: >- + Thyroid Gland Hyalinizing Trabecular Tumor + source: NCIt + cde_id: C6846 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6846" + term_id: C6846 + term_version: 20.05a + +hyaluronidasezzxfpertuzumabtrastuzumab: + common: + description: >- + A ready-to-use fixed-dose combination of pertuzumab and trastuzumab, both recombinant + humanized monoclonal antibodies directed against the tyrosine kinase receptor + (TKR) human epidermal growth factor receptor 2 (HER2; HER-2; receptor tyrosine-protein + kinase erbB-2), and hyaluronidase-zzxf, a biosimilar of the recombinant form + of the naturally occurring endoglycosidase hyaluronidase, with antineoplastic + activity that can be used for the treatment of HER2-overexpressing breast cancers. + Upon subcutaneous administration, hyaluronidase-zzxf temporarily breaks down + the hyaluronan barrier, which decreases viscosity of, and allows both pertuzumab + and trastuzumab to spread rapidly through the interstitial space. This improves + access to lymphatic and capillary vessels and facilitates the absorption of + both antibodies into the bloodstream. Pertuzumab targets and binds to the extracellular + dimerization domain (subdomain II) of HER2 and blocks ligand-dependent heterodimerization + of HER2 with other HER family members, including EGFR, HER3 and HER4. This inhibits + ligand-initiated intracellular signaling and prevents the activation of the + mitogen-activated protein (MAP) kinase and the phosphoinositide 3-kinase (PI3K) + signaling pathways, leading to growth arrest and apoptosis in HER2-overexpressing + tumor cells, respectively. Trastuzumab targets and binds to subdomain IV of + HER2 and inhibits ligand-independent, HER2 mediated cell proliferation and inhibits + the PI3K signaling pathway in HER2-overexpressing tumor cells. Both antibodies + induce an antibody-dependent cell-mediated cytotoxicity (ADCC) against HER2-expressing + tumor cells. HER2 is overexpressed in many adenocarcinomas, particularly breast + adenocarcinomas. + termDef: + term: >- + Hyaluronidase-zzxf/Pertuzumab/Trastuzumab + source: NCIt + cde_id: C173339 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173339" + term_id: C173339 + term_version: 20.10d + +hydatid_mole: + common: + description: >- + A gestational trophoblastic disorder characterized by marked enlargement of + the chorionic villi, hyperplasia of the villous trophoblastic cells and hydropic + changes. + termDef: + term: >- + Hydatidiform Mole + source: NCIt + cde_id: C3110 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3110" + term_id: C3110 + term_version: 20.05a + +hydatidiform_mole_nos: + common: + description: >- + A gestational trophoblastic disorder characterized by marked enlargement of + the chorionic villi, hyperplasia of the villous trophoblastic cells and hydropic + changes. + termDef: + term: >- + Hydatidiform Mole + source: NCIt + cde_id: C3110 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3110" + term_id: C3110 + term_version: 20.05a + +hydroa_vacciniformelike_lymphoma: + common: + description: >- + A rare, EBV-positive cutaneous T-cell lymphoproliferative disorder, composed + of CD8 positive cytotoxic T-lymphocytes. It affects children, almost exclusively + in Latin America and Asia. Patients present with papulovesicular skin lesions, + clinically resembling hydroa vacciniforme, in areas of sun-exposed skin. + termDef: + term: >- + Hydroa Vacciniforme-Like Lymphoproliferative Disorder + source: NCIt + cde_id: C45327 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45327" + term_id: C45327 + term_version: 20.05a + +hygroma_nos: + common: + description: >- + A benign lymphatic neoplasm usually arising from the neck and characterized + by cystic dilation of the lymphatic vessels. + termDef: + term: >- + Cystic Hygroma + source: NCIt + cde_id: C3724 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3724" + term_id: C3724 + term_version: 20.05a + +hyperdiploid: + common: + description: >- + A chromosomal abnormality in which the chromosomal number is greater than the + normal diploid number. + termDef: + term: >- + Hyperdiploidy + source: NCIt + cde_id: C80336 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80336" + term_id: C80336 + term_version: 20.10d + +hypereosinophilic_syndrome: + common: + description: >- + A syndrome characterized by persistent eosinophilia, for which no underlying + cause can be found, and which is associated with signs of organ involvement + and dysfunction. This term has often been applied to cases of chronic eosinophilic + leukemia. (WHO, 2001) + termDef: + term: >- + Hypereosinophilic Syndrome + source: NCIt + cde_id: C27038 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27038" + term_id: C27038 + term_version: 20.05a + +hypermethylation: + common: + description: >- + Hypermethylation appears to be a controlled, epigenetic, heritable, and aberrant + DNA methylation reaction on gene promoter regions and CpG islands associated + with loss of (e.g., tumor-suppressor) gene function in diverse cellular pathways + through transcriptional silencing by the formation of transcriptionally repressive + chromatin. + termDef: + term: >- + Hypermethylation + source: NCIt + cde_id: C20102 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20102" + term_id: C20102 + term_version: 20.10d + +hypernephroma: + common: + description: >- + A malignant epithelial neoplasm of the kidney characterized by the presence + of lipid-containing clear cells within a vascular network. The tumor may metastasize + to unusual sites and late metastasis is common. + termDef: + term: >- + Clear Cell Renal Cell Carcinoma + source: NCIt + cde_id: C4033 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4033" + term_id: C4033 + term_version: 20.05a + +hypodiploid: + common: + description: >- + A chromosomal abnormality in which the chromosomal number is less than the normal + diploid number. + termDef: + term: >- + Hypodiploidy + source: NCIt + cde_id: C80337 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80337" + term_id: C80337 + term_version: 20.10d + +hypopharynx_nos: + common: + description: >- + The lower part of the pharynx that connects to the esophagus. + termDef: + term: >- + Hypopharynx + source: NCIt + cde_id: C12246 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12246" + term_id: C12246 + term_version: 20.05a + +i: + common: + description: >- + Plasma cell myeloma with beta-2-microglobulin less than 3.5 and albumin greater + than or equal to 3.5 (median survival of 62 months). Note that the older Durie/Salmon + staging system defines stage I quite differently. (PDQ) + termDef: + term: >- + ISS Stage I Plasma Cell Myeloma + source: NCIt + cde_id: C70658 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70658" + term_id: C70658 + term_version: 20.05a + diagnosis: + clark_level: + description: >- + A morphologic finding indicating that the cutaneous melanoma is confined to + the epidermis and does not invade the dermis. + termDef: + term: >- + Clark Level I + source: NCIt + cde_id: C94812 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94812" + term_id: C94812 + term_version: 23.03d + other_clinical_attribute: + myasthenia_gravis_classification: + description: >- + Myasthenia gravis presenting with any ocular weakness; may have weakness of + eye closure. All other muscles strength is normal. + termDef: + term: >- + Class I + source: NCIt + cde_id: C112014 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112014&ns=ncit" + term_id: C112014 + term_version: 23.08d + +iadademstat: + common: + description: >- + An orally available inhibitor of lysine specific histone demethylase 1 (KDM1A; + LSD1), with potential antineoplastic activity. Upon administration, iadademstat + binds to and inhibits LSD1, a demethylase that suppresses the expression of + target genes by converting the di- and mono-methylated forms of lysine at position + 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively. LSD1 inhibition + enhances H3K4 methylation and increases the expression of tumor suppressor genes. + This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. + In addition, LSD1 demethylates mono- or di-methylated H3K9, which increases + gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation + and decreases transcription of these genes. LSD1, an enzyme belonging to the + flavin adenine dinucleotide (FAD)-dependent amine oxidase family, is overexpressed + in certain tumor cells and plays a key role in in the regulation of gene expression, + tumor cell growth and survival. + termDef: + term: >- + Iadademstat + source: NCIt + cde_id: C131908 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131908" + term_id: C131908 + term_version: 20.10d + +ianalumab: + common: + description: >- + A fully human combinatorial antibody library (HuCAL)-derived monoclonal antibody + targeting the B-cell-activating factor receptor (BAFF-R), with potential anti-inflammatory + and antineoplastic activities. Upon administration, ianalumab targets and binds + to BAFF-R, which inhibits both BAFF/BAFF-R interaction and BAFF-R-mediated signaling. + This may decrease cell growth in tumor cells expressing BAFF-R. BAFF-R, also + known as tumor necrosis factor receptor superfamily member 13C, is overexpressed + in certain tumor cell types and autoimmune diseases. In cancer cells, BAFF-R + plays a key role in B-cell proliferation and survival. VAY736 was developed + using HuCAL technology. + termDef: + term: >- + Ianalumab + source: NCIt + cde_id: C116788 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116788" + term_id: C116788 + term_version: 20.10d + +iceland: + common: + description: >- + A country in northern Europe, island between the Greenland Sea and the North + Atlantic Ocean, northwest of the UK. + termDef: + term: >- + Iceland + source: NCIt + cde_id: C16704 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16704" + term_id: C16704 + term_version: 19.12e + +id3: + common: + description: >- + This gene plays a role in transcriptional repression. + termDef: + term: >- + ID3 Gene + source: NCIt + cde_id: C102968 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102968" + term_id: C102968 + term_version: 20.10d + +identical_twin_brother: + common: + description: >- + A male full sibling that developed from a shared ovum. + termDef: + term: >- + Identical Twin Brother + source: NCIt + cde_id: C165848 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165848" + term_id: C165848 + term_version: 19.12e + +identical_twin_sibling: + common: + description: >- + Either of the two offspring resulting from a shared ovum. + termDef: + term: >- + Identical Twin + source: NCIt + cde_id: C73429 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73429" + term_id: C73429 + term_version: 19.12e + +identical_twin_sister: + common: + description: >- + A female full sibling that developed from a shared ovum. + termDef: + term: >- + Identical Twin Sister + source: NCIt + cde_id: C165849 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165849" + term_id: C165849 + term_version: 19.12e + +idetrexed: + common: + description: >- + An alpha-folate receptor (aFR)-mediated inhibitor of thymidylate synthase (TS), + with potential antineoplastic activity. Upon intravenous infusion, idetrexed + selectively targets and binds to aFR-expressing tumor cells. Upon uptake by + aFR, this agent binds to and inhibits TS. This reduces thymine nucleotide synthesis, + inhibits both DNA synthesis and cell division, and leads to tumor cell apoptosis. + TS catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine + monophosphate (dTMP), an essential precursor for DNA synthesis, and plays a + key role in cell growth and division. aFR, a cell-surface receptor glycoprotein, + is overexpressed on various tumor cell types, but is minimally expressed by + normal, healthy tissue. + termDef: + term: >- + Idetrexed + source: NCIt + cde_id: C120550 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C120550" + term_id: C120550 + term_version: 20.10d + +idh1: + common: + description: >- + This gene plays a role in carbohydrate metabolism. + termDef: + term: >- + IDH1 Gene + source: NCIt + cde_id: C77215 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77215" + term_id: C77215 + term_version: 20.10d + +idh1_mutant_inhibitor_ly3410738: + common: + description: >- + An orally available inhibitor of mutant form of the isocitrate dehydrogenase + type 1 (IDH1; IDH-1; IDH1 [NADP+] soluble), including the substitution mutation + at arginine (R) in position 132, IDH1(R132), with potential antineoplastic activity. + Upon oral administration, IDH1 mutant inhibitor LY3410738 specifically and covalently + binds to and modifies a single cysteine (Cys269) in the allosteric binding pocket + of mutant forms of IDH1, thereby inactivating IDH1. This inhibits the formation + of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). + This depletes 2-HG levels, prevents 2HG-mediated signaling and leads to both + an induction of cellular differentiation and an inhibition of cellular proliferation + in tumor cells expressing mutant forms of IDH1. In addition, LY3410738 has the + ability to cross the blood-brain barrier (BBB). IDH1 mutations, including IDH1(R132) + mutations, are highly expressed in certain malignancies, including gliomas; + they initiate and drive cancer growth by both blocking cell differentiation + and catalyzing the formation of 2HG. + termDef: + term: >- + IDH1 Mutant Inhibitor LY3410738 + source: NCIt + cde_id: C175542 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175542" + term_id: C175542 + term_version: 20.10d + +idh2: + common: + description: >- + This gene plays a role in intermediary metabolism. + termDef: + term: >- + IDH2 Gene + source: NCIt + cde_id: C84948 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84948" + term_id: C84948 + term_version: 20.10d + +idiopathic_hemorrhagic_thrombocythaemia: + common: + description: >- + A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic + lineage. It is characterized by sustained thrombocytosis in the blood, increased + numbers of large, mature megakaryocytes in the bone marrow, and episodes of + thrombosis and/or hemorrhage. (WHO, 2008) + termDef: + term: >- + Essential Thrombocythemia + source: NCIt + cde_id: C3407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3407" + term_id: C3407 + term_version: 20.05a + +idiopathic_thrombocythemia: + common: + description: >- + A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic + lineage. It is characterized by sustained thrombocytosis in the blood, increased + numbers of large, mature megakaryocytes in the bone marrow, and episodes of + thrombosis and/or hemorrhage. (WHO, 2008) + termDef: + term: >- + Essential Thrombocythemia + source: NCIt + cde_id: C3407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3407" + term_id: C3407 + term_version: 20.05a + +ido1tdo2_inhibitor_m4112: + common: + description: >- + An inhibitor of both the enzymes indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1) + and tryptophan 2,3-dioxygenase 2 (TDO2; TDO-2), with potential immunomodulating + and antineoplastic activities. Upon administration, IDO1/TDO2 inhibitor M4112 + targets, binds to and inhibits both IDO1 and TDO2, which catalyze the first + and rate-limiting step in the production of the immunosuppressive transcription + factor aryl hydrocarbon receptor (AhR) ligand kynurenine (Kyn). This inhibits + the IDO1/TDO2-Kyn-AhR pathway and abrogates AhR activation. This prevents the + activation of immune-tolerant dendritic cells (DCs) and regulatory T-cells (Tregs) + in the tumor microenvironment (TME), and may restore the immune response by + stimulating a cytotoxic T-lymphocyte (CTL) immune response against tumor cells + in which IDO1 and/or TDO2 are overexpressed. The IDO1/TDO2-KYN-AhR pathway is + overexpressed in a variety of tumor cell types and plays a key role in immunosuppression. + Its expression is correlated with poor prognosis. + termDef: + term: >- + IDO1/TDO2 Inhibitor M4112 + source: NCIt + cde_id: C168808 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168808" + term_id: C168808 + term_version: 20.10d + +idotdo_inhibitor_ly01013: + common: + description: >- + An orally bioavailable, small-molecule inhibitor of indoleamine 2,3-dioxygenase + 1 (IDO1; IDO-1) and the kynurenine-producing hepatic enzyme tryptophan 2,3-dioxygenase + (TDO), with potential immunomodulating and antineoplastic activities. Upon administration, + IDO1/TDO inhibitor LY-01013 specifically targets and binds to both IDO1, a cytosolic + enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive + metabolite kynurenine, and TDO, a hepatic enzyme catalyzing the first step of + tryptophan degradation. By inhibiting IDO1 and TDO, LY-01013 decreases kynurenine + levels in tumor cells, restores tryptophan and promotes the proliferation and + activation of various immune cells, including dendritic cells (DCs), natural + killer (NK) cells and T-lymphocytes. This reduces the number of tumor-associated + regulatory T-cells (Tregs) and activates the immune system to induce a cytotoxic + T-lymphocyte (CTL) response against the IDO1/TDO-expressing tumor cells, thereby + inhibiting the growth of the tumor cells. IDO1 and TDO, both overexpressed by + multiple tumor cell types, play important roles in immunosuppression and the + promotion of tumor cell survival and proliferation. Tryptophan depletion inhibits + T-lymphocyte proliferation and activation, and subsequently suppresses the immune + system. + termDef: + term: >- + IDO/TDO Inhibitor LY-01013 + source: NCIt + cde_id: C171343 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171343" + term_id: C171343 + term_version: 20.10d + +ieramilimab: + common: + description: >- + A humanized monoclonal antibody directed against the inhibitory receptor lymphocyte + activation gene-3 (LAG-3), with potential immunomodulating and antineoplastic + activities. Upon administration, Ieramilimab binds to LAG-3 expressed on tumor-infiltrating + lymphocytes (TILs) and blocks its binding with major histocompatibility complex + (MHC) class II molecules expressed on tumor cells. This activates antigen-specific + T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which + leads to a reduction in tumor growth. LAG-3, a member of the immunoglobulin + superfamily (IgSF) and expressed on various immune cells, negatively regulates + cellular proliferation and activation of T-cells. Its expression on TILs is + associated with tumor-mediated immune suppression. + termDef: + term: >- + Ieramilimab + source: NCIt + cde_id: C122683 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122683" + term_id: C122683 + term_version: 20.10d + +igh: + common: + description: >- + This region represents the germline organization of the immunoglobulin heavy + chain locus. The locus includes V (variable), J (joining), diversity (D), and + C (constant) segments. During B cell development, a recombination event at the + DNA level joins a D segment with a J segment; a V segment is then joined to + the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination + of many different V segments with several D and J segments provides a wide range + of antigen recognition. Additional diversity is attained by junctional diversity, + resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, + and by somatic hypermutation, which occurs during B cell maturation in the spleen + and lymph nodes. (from LocusLink) + termDef: + term: >- + Immunoglobulin Heavy Locus + source: NCIt + cde_id: C26422 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26422" + term_id: C26422 + term_version: 20.10d + +igk: + common: + description: >- + This region represents the germline organization of the kappa light chain locus. + The locus includes V (variable), J (joining), and C (constant) segments. During + B cell development, a recombination event at the DNA level joins a single V + segment with a J segment; the C segment is later joined by splicing at the RNA + level. Recombination of many different V segments with several J segments provides + a wide range of antigen recognition. Additional diversity is attained by junctional + diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, + and by somatic hypermutation, which occurs during B cell maturation in the spleen + and lymph nodes. (from LocusLink) + termDef: + term: >- + Immunoglobulin Kappa Locus + source: NCIt + cde_id: C26425 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26425" + term_id: C26425 + term_version: 20.10d + +igkc: + common: + description: >- + This gene plays a role in the structure of immunoglobulin light chains. + termDef: + term: >- + IGKC Gene + source: NCIt + cde_id: C171139 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171139" + term_id: C171139 + term_version: 20.10d + +igl: + common: + description: >- + This region represents the germline organization of the lambda light chain locus. + The locus includes V (variable), J (joining), and C (constant) segments. During + B cell development, a recombination event at the DNA level joins a single V + segment with a J segment; the C segment is later joined by splicing at the RNA + level. Recombination of many different V segments with several J segments provides + a wide range of antigen recognition. Additional diversity is attained by junctional + diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, + and by somatic hypermutation, which occurs during B cell maturation in the spleen + and lymph nodes. (from LocusLink) + termDef: + term: >- + Immunoglobulin Lambda Locus + source: NCIt + cde_id: C26423 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26423" + term_id: C26423 + term_version: 20.10d + +ihc: + common: + description: >- + Immunohistochemical staining techniques allow for the visualization of antigens + via the sequential application of a specific antibody to the antigen (primary + antibody), a secondary antibody to the primary antibody and an enzyme complex + with a chromogenic substrate. The enzymatic activation of the chromogen results + in a visible reaction product at the antigen site. The specimen may then be + counterstained and coverslipped. Results are interpreted using a light microscope + and aid in the differential diagnosis of pathophysiological processes, which + may or may not be associated with a particular antigen. + termDef: + term: >- + Immunohistochemistry Staining Method + source: NCIt + cde_id: C23020 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C23020" + term_id: C23020 + term_version: 20.10d + +ii: + common: + description: >- + Plasma cell myeloma with blood levels of beta-2-microglobulin between 3.5 and + 5.5 mg/L. + termDef: + term: >- + ISS Stage II Plasma Cell Myeloma + source: NCIt + cde_id: C70659 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70659" + term_id: C70659 + term_version: 20.05a + diagnosis: + clark_level: + description: >- + A morphologic finding indicating that the cutaneous melanoma has invaded part + of the papillary dermis but the malignant cellular infiltrate has not reached + the papillary-reticular dermis interface. + termDef: + term: >- + Clark Level II + source: NCIt + cde_id: C94813 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94813" + term_id: C94813 + term_version: 23.03d + other_clinical_attribute: + myasthenia_gravis_classification: + description: >- + Myasthenia gravis presenting with mild weakness affecting non-ocular muscles. + May also have ocular muscle weakness of any severity. + termDef: + term: >- + Class II + source: NCIt + cde_id: C112015 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112015&ns=ncit" + term_id: C112015 + term_version: 23.08d + +iii: + common: + description: >- + Plasma cell myeloma with beta-2-microglobulin greater than or equal to 5.5 (median + survival of 29 months). Note that the older Durie/Salmon staging system defines + stage III quite differently. (PDQ) + termDef: + term: >- + ISS Stage III Plasma Cell Myeloma + source: NCIt + cde_id: C70660 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70660" + term_id: C70660 + term_version: 20.05a + diagnosis: + clark_level: + description: >- + A morphologic finding indicating that the cutaneous melanoma has invaded the + entire thickness of the papillary dermis but the malignant cellular infiltrate + does not extend into the reticular dermis. + termDef: + term: >- + Clark Level III + source: NCIt + cde_id: C94814 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94814" + term_id: C94814 + term_version: 23.03d + other_clinical_attribute: + myasthenia_gravis_classification: + description: >- + Myasthenia gravis presenting with moderate weakness affecting non-ocular muscles. + May also have ocular muscle weakness of any severity. + termDef: + term: >- + Class III + source: NCIt + cde_id: C112016 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112016&ns=ncit" + term_id: C112016 + term_version: 23.08d + +ikbkb: + common: + description: >- + This gene is involved in protein phosphorylation. + termDef: + term: >- + IKBKB Gene + source: NCIt + cde_id: C96383 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96383" + term_id: C96383 + term_version: 20.10d + +ikzf1: + common: + description: >- + This gene is involved in B-cell and T-cell maturation. + termDef: + term: >- + IKZF1 Gene + source: NCIt + cde_id: C68730 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68730" + term_id: C68730 + term_version: 20.10d + +il12sc_il15sushi_ifna_and_gmcsf_mrnabased_immunotherapeutic_agent_sar441000: + common: + description: >- + An immunotherapeutic agent utilizing mRNA to encode the cytokines interleukin-12sc + (IL-12sc), interleukin-15sushi (IL-15sushi), interferon alpha (IFNa) and granulocyte-macrophage + colony-stimulating factor (GM-CSF), with potential immunomodulating and antineoplastic + activities. Upon intratumoral administration of IL-12sc, IL-15sushi, IFNa and + GM-CSF mRNA-based immunotherapeutic agent SAR441000, mRNA is picked up by nearby + cells, translated and released into the local tumor microenvironment (TME). + Secretion of these cytokines activate the immune system by promoting the activation + of natural killer cells (NKs) and inducing cytotoxic T-lymphocyte (CTL) responses, + which may result in an immune-mediated destruction of tumor cells. + termDef: + term: >- + IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000 + source: NCIt + cde_id: C166375 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166375" + term_id: C166375 + term_version: 20.10d + +il2: + common: + description: >- + This gene is involved in growth and lymphokine regulation. + termDef: + term: >- + IL2 Gene + source: NCIt + cde_id: C24498 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24498" + term_id: C24498 + term_version: 20.10d + +il21r: + common: + description: >- + This gene is involved in cytokine recognition. + termDef: + term: >- + IL21R Gene + source: NCIt + cde_id: C68736 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68736" + term_id: C68736 + term_version: 20.10d + +il6st: + common: + description: >- + This gene plays a role in signal transduction and is putatively involved in + embryonic development. + termDef: + term: >- + IL6ST Gene + source: NCIt + cde_id: C24505 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24505" + term_id: C24505 + term_version: 20.10d + +il7r: + common: + description: >- + This gene is involved in the regulation of lymphopoiesis. + termDef: + term: >- + IL7R Gene + source: NCIt + cde_id: C24506 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24506" + term_id: C24506 + term_version: 20.10d + +ileum: + common: + description: >- + The final section of the small intestine. + termDef: + term: >- + Ileum + source: NCIt + cde_id: C12387 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12387" + term_id: C12387 + term_version: 20.05a + +ilginatinib: + common: + description: >- + An orally bioavailable, small molecule inhibitor of Janus-associated kinase + 2 (JAK2) and Src-family kinases, with potential antineoplastic activity. Ilginatinib + competes with ATP for binding to JAK2 as well as the mutated form JAK2V617F, + thereby inhibiting the activation of JAK2 and downstream molecules in the JAK2/STAT3 + (signal transducer and activator of transcription 3) signaling pathway that + plays an important role in normal development, particularly hematopoiesis. In + addition, ilginatinib inhibits the Src family tyrosine kinases. This eventually + leads to the induction of tumor cell apoptosis. JAK2 is the most common mutated + gene in bcr-abl-negative myeloproliferative disorders (MPDs); JAK2V617F is a + constitutively activated kinase that activates the JAK/STAT signaling pathway + and dysregulates cell growth and function, and its expression transforms hematopoietic + cells to cytokine-independent growth. + termDef: + term: >- + Ilginatinib + source: NCIt + cde_id: C98109 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98109" + term_id: C98109 + term_version: 20.10d + +iliac_nos: + common: + description: >- + One of the three lymph nodes of the pelvis: the superior gluteal, interior gluteal + or sacral. + termDef: + term: >- + Iliac Lymph Node + source: NCIt + cde_id: C32761 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32761" + term_id: C32761 + term_version: 20.10d + +iliaccommon: + common: + description: >- + A lymph node located adjacent to the common iliac artery. (NCI) + termDef: + term: >- + Common Iliac Lymph Node + source: NCIt + cde_id: C103384 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C103384" + term_id: C103384 + term_version: 20.10d + +iliacexternal: + common: + description: >- + A lymph node located along the external iliac artery. + termDef: + term: >- + External Iliac Lymph Node + source: NCIt + cde_id: C88143 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C88143" + term_id: C88143 + term_version: 20.10d + +illdefined_sites_within_respiratory_system: + common: + description: >- + Anatomic sites within the respiratory system and intrathoracic organs that are + referenced in topographic category C39 of ICD-O-3. + termDef: + term: >- + Other and Ill-Defined Sites within Respiratory System and Intrathoracic Organs + ICD-O-3 + source: NCIt + cde_id: C148338 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148338" + term_id: C148338 + term_version: 20.05a + +imaging: + common: + description: >- + Any technology or method that aids in the visualization of any biological process, + cell, tissue or organ for use in screening, diagnosis, surgical procedures or + therapy. + termDef: + term: >- + Imaging Technique + source: NCIt + cde_id: C17369 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17369" + term_id: C17369 + term_version: 20.05a + +imaradenant: + common: + description: >- + An orally bioavailable antagonist of the adenosine A2A receptor (A2AR; ADORA2A), + with potential immunomodulating and antineoplastic activities. Upon administration, + imaradenant selectively binds to and inhibits A2AR expressed on T-lymphocytes. + This blocks tumor-released adenosine from interacting with A2AR and prevents + the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in the + proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated + immune response against tumor cells. A2AR, a G protein-coupled receptor, is + highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, + inhibits T-cell proliferation and activation. Adenosine is often overproduced + by cancer cells and plays a key role in immunosuppression. + termDef: + term: >- + Imaradenant + source: NCIt + cde_id: C148039 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148039" + term_id: C148039 + term_version: 20.10d + +imgatuzumab: + common: + description: >- + A glycoengineered monoclonal antibody directed against the epidermal growth + factor receptor (EGFR) with potential antineoplastic activity. Imgatuzumab binds + to the extracellular domain of EGFR, preventing the activation and subsequent + dimerization of the receptor; the decrease in receptor activation and dimerization + may result in an inhibition of downstream ERK and JNK signaling pathways and + so inhibition of EGFR-dependent tumor cell proliferation and metastasis. EGFR, + a member of the epidermal growth factor family of extracellular protein ligands, + may be overexpressed on the cell surfaces of various solid tumor cell types. + termDef: + term: >- + Imgatuzumab + source: NCIt + cde_id: C78838 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C78838" + term_id: C78838 + term_version: 20.10d + +imifoplatin: + common: + description: >- + A platinum (Pt)-based agent belonging to the phosphaplatin family comprised + of Pt complexed to a pyrophosphate ligand, with potential antineoplastic activity. + Although the exact mechanisms through which imifoplatin exerts its effect have + yet to be fully elucidated, this agent, upon intravenous administration, binds + to certain transmembrane proteins and activates several genes involved in tumor + suppression and apoptosis. This leads to the activation of various signal transduction + pathways, induces S/G2 phase cell cycle, and causes tumor cell apoptosis. In + addition, imifoplatin may inhibit angiogenesis. Unlike conventional Pt-based + chemotherapeutics, imifoplatin does not bind to DNA and is able to overcome + drug resistance, which occurs with conventional Pt-based chemotherapeutics; + it also has a more favorable side effect profile and is more stable in plasma. + termDef: + term: >- + Imifoplatin + source: NCIt + cde_id: C121375 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121375" + term_id: C121375 + term_version: 20.10d + +immature_teratoma_malignant: + common: + description: >- + A teratoma characterized by the presence of an extensive component of immature, + fetal-type tissues. + termDef: + term: >- + Immature Teratoma + source: NCIt + cde_id: C4286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4286" + term_id: C4286 + term_version: 20.05a + +immature_teratoma_nos: + common: + description: >- + A teratoma characterized by the presence of an extensive component of immature, + fetal-type tissues. + termDef: + term: >- + Immature Teratoma + source: NCIt + cde_id: C4286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4286" + term_id: C4286 + term_version: 20.05a + +immunoblastic_sarcoma: + common: + description: >- + A diffuse large B-cell lymphoma characterized by the presence of immunoblasts + with uniformly round-to-oval nuclei, a prominent nucleolus, and abundant cytoplasm. + termDef: + term: >- + Immunoblastic Lymphoma + source: NCIt + cde_id: C3461 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3461" + term_id: C3461 + term_version: 20.05a + +immunocytoma: + common: + description: >- + An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes + (centrocyte-like cells). The gastrointestinal tract is the most common site + of involvement. Other common sites of involvement include lung, head and neck, + ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated + with the presence of H. pylori infection. (WHO, 2001) + termDef: + term: >- + Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue + source: NCIt + cde_id: C3898 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3898" + term_id: C3898 + term_version: 20.05a + +immunodeficiencyassociated_adult: + common: + description: >- + Burkitt lymphoma in a patient with immunodeficiency. + termDef: + term: >- + Immunodeficiency-Related Burkitt Lymphoma + source: NCIt + cde_id: C27915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27915" + term_id: C27915 + term_version: 20.05a + +immunodeficiencyassociated_pediatric: + common: + description: >- + Burkitt lymphoma in a patient with immunodeficiency. + termDef: + term: >- + Immunodeficiency-Related Burkitt Lymphoma + source: NCIt + cde_id: C27915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27915" + term_id: C27915 + term_version: 20.05a + +immunofluorescence: + common: + description: >- + A microscopy staining method that utilizes immunofluorescent markers for use + with histological applications of preserved cells. + termDef: + term: >- + Immunofluorescent Staining Method + source: NCIt + cde_id: C142337 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142337" + term_id: C142337 + term_version: 20.10d + +immunoglobulin_a: + common: + description: >- + The determination of the amount of immunoglobulin A present in a sample. + termDef: + term: >- + Immunoglobulin A Measurement + source: NCIt + cde_id: C81969 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81969" + term_id: C81969 + term_version: 20.10d + +immunoglobulin_deposition_disease: + common: + description: >- + A plasma cell neoplasm characterized by the deposition of immunoglobulin in + tissues, resulting in impaired organ function. It includes the following entities: + primary amyloidosis, heavy chain deposition disease, and light chain deposition + disease. + termDef: + term: >- + Monoclonal Immunoglobulin Deposition Disease + source: NCIt + cde_id: C7151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7151" + term_id: C7151 + term_version: 20.05a + +immunoglobulin_g: + common: + description: >- + The determination of the amount of immunoglobulin G present in a sample. + termDef: + term: >- + Immunoglobulin G Measurement + source: NCIt + cde_id: C81971 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81971" + term_id: C81971 + term_version: 20.10d + +immunoglobulin_m: + common: + description: >- + The determination of the amount of immunoglobulin M present in a sample. + termDef: + term: >- + Immunoglobulin M Measurement + source: NCIt + cde_id: C81972 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81972" + term_id: C81972 + term_version: 20.10d + +immunoproliferative_small_intestinal_disease: + common: + description: >- + A clonal disorder, also known as immunoproliferative small intestinal disease + or Mediterranean lymphoma, characterised by the secretion of a defective alpha + heavy chain. It predominantly affects young people in the Mediterranean region. It + involves the small intestine, and patients usually present with malabsorption + syndrome, abdominal pain, weight loss, and fever. There is extensive villous + atrophy of the small intestinal mucosa, which is heavily infiltrated by small + lymphocytes and plasma cells. The small intestinal morphologic changes are + consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). + termDef: + term: >- + Alpha Heavy Chain Disease + source: NCIt + cde_id: C3132 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3132" + term_id: C3132 + term_version: 20.05a + +imrimmunoresponse: + common: + description: >- + A marked decrease in contrast enhancement that is not due to actual tumor shrinkage, + but that may be due to immunotherapy. + termDef: + term: >- + Immunoresponse + source: NCIt + cde_id: C131144 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131144" + term_id: C131144 + term_version: 20.05a + +inactivated_oncolytic_virus_particle_gen0101: + common: + description: >- + An inactivated, non-replicating particle of hemagglutinating virus of Japan + (HVJ), an oncolytic virus of the paramyxovirus family, with potential immunostimulating + and antineoplastic activities. Upon intracutaneous administration, GEN0101 targets + and binds to the cytosolic nucleic acid receptor retinoic acid-inducible gene + I (RIG-I). This induces RIG-I-mediated signaling and a potent innate immune + response against tumor cells, leading to the activation of natural killer (NK) + cells and cytotoxic T-lymphocytes (CTL), and apoptosis in tumor cells. GEN0101 + also activates dendritic cells (DCs) to produce cytokine interleukin-6 (IL-6), + suppressing the function of regulatory T cells (Treg), a negative regulator + of immune responses. The suppression of Treg activity helps maintain the induced + immune responses. + termDef: + term: >- + Inactivated Oncolytic Virus Particle GEN0101 + source: NCIt + cde_id: C170893 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170893" + term_id: C170893 + term_version: 20.10d + +incisional_biopsy: + common: + description: >- + A surgical procedure in which part of a lesion is removed for microscopic examination. + termDef: + term: >- + Incisional Biopsy + source: NCIt + cde_id: C15386 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15386" + term_id: C15386 + term_version: 20.05a + +indatuximab_ravtansine: + common: + description: >- + An immunoconjugate consisting of a monoclonal antibody directed against a highly-expressed + myeloma cell surface antigen covalently attached to the maytansinoid DM4, a + derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic + activity. Indatuximab ravtansine binds to an unspecified cell surface antigen + highly expressed on myeloma cells; upon internalization the DM4 moiety is released, + binding to tubulin and disrupting microtubule assembly/disassembly dynamics, + which may result in the inhibition of cell division and cell growth of myeloma + tumor cells. + termDef: + term: >- + Indatuximab Ravtansine + source: NCIt + cde_id: C78840 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C78840" + term_id: C78840 + term_version: 20.10d + +indefinite: + common: + description: >- + An indication that there is an ambiguous morphological pattern in a tissue sample + such that the presence or absence of dysplasia cannot be determined. + termDef: + term: >- + Indefinite Dysplasia + source: NCIt + cde_id: C164039 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164039" + term_id: C164039 + term_version: 20.10d + +indefinite_for_dysplasia: + common: + description: >- + An indication that there is an ambiguous morphological pattern in a tissue sample + such that the presence or absence of dysplasia cannot be determined. + termDef: + term: >- + Indefinite Dysplasia + source: NCIt + cde_id: C164039 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164039" + term_id: C164039 + term_version: 20.05a + +indeterminant: + common: + description: >- + Cannot distinguish between two or more possible values in the current context. + termDef: + term: >- + Indeterminate + source: NCIt + cde_id: C48658 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48658" + term_id: C48658 + term_version: 20.10d + +indeterminate: + common: + description: >- + Cannot distinguish between two or more possible values in the current context. + termDef: + term: >- + Indeterminate + source: NCIt + cde_id: C48658 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48658" + term_id: C48658 + term_version: 20.05a + +indeterminate_dendritic_cell_tumor: + common: + description: >- + A very rare dendritic cell tumor composed of spindle to ovoid cells with a phenotype + that is similar to the Langerhans cells. Patients usually present with cutaneous + papules, nodules, and plaques. Systemic symptoms are usually absent. The clinical + course is variable. + termDef: + term: >- + Indeterminate Dendritic Cell Tumor + source: NCIt + cde_id: C81767 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81767" + term_id: C81767 + term_version: 20.05a + +india: + common: + description: >- + A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, + between Pakistan and China. + termDef: + term: >- + India + source: NCIt + cde_id: C16727 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16727" + term_id: C16727 + term_version: 19.12e + +individualized_mvabased_vaccine_tg4050: + common: + description: >- + An off-the-shelf (OTS) individualized vaccine comprised of a modified Vaccinia + virus Ankara (MVA) viral vector encoding tumor-specific neoantigens (TSNAs), + with potential immunostimulatory and antineoplastic activities. Following administration + of the individualized MVA-based vaccine TG4050, the neoantigens are expressed + and presented to the immune system, which induces the activation of a specific + cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing + the patient-specific neoantigens. + termDef: + term: >- + Individualized MVA-based Vaccine TG4050 + source: NCIt + cde_id: C171392 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171392" + term_id: C171392 + term_version: 20.10d + +indolent_systemic_mastocytosis: + common: + description: >- + An indolent mast cell neoplasm characterized by systemic infiltration of skin + and internal organs by aggregates of neoplastic mast cells. There is no evidence + of mast cell leukemia or clonal hematologic malignancy. Clinically, there is + no evidence of palpable hepatomegaly and splenomegaly, malabsorption syndrome, + or pathologic fractures. + termDef: + term: >- + Indolent Systemic Mastocytosis + source: NCIt + cde_id: C9286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9286" + term_id: C9286 + term_version: 20.05a + +indonesia: + common: + description: >- + A country in southeastern Asia, comprising the archipelago and islands between + the Indian Ocean and the Pacific Ocean, north of Australia. + termDef: + term: >- + Indonesia + source: NCIt + cde_id: C16728 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16728" + term_id: C16728 + term_version: 19.12e + +indoor_stove_or_fireplace_smoke_coal_burning: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when coal is subjected to combustion in an indoor stove or fireplace. + termDef: + term: >- + Coal-Burining Indoor Stove or Fireplace Smoke Exposure + source: NCIt + cde_id: C164088 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164088" + term_id: C164088 + term_version: 19.12e + +indoor_stove_or_fireplace_smoke_nos: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when materials are subjected to combustion in an indoor stove or fireplace. + termDef: + term: >- + Indoor Stove or Fireplace Smoke Exposure + source: NCIt + cde_id: C164064 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164064" + term_id: C164064 + term_version: 19.12e + +indoor_stove_or_fireplace_smoke_wood_burning: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when wood is subjected to combustion in an indoor stove or fireplace. + termDef: + term: >- + Wood-Burning Indoor Stove or Fireplace Smoke Exposure + source: NCIt + cde_id: C164089 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164089" + term_id: C164089 + term_version: 19.12e + +indusatumab_vedotin: + common: + description: >- + An antibody-drug conjugate (ADC) containing a monoclonal antibody directed against + guanylyl cyclase C (GCC or GUCY2C) conjugated to monomethylauristatin E (MMAE), + an auristatin derivative and a potent microtubule inhibitor, with potential + antineoplastic activity. The monoclonal antibody moiety of indusatumab vedotin + selectively binds to GCC, a transmembrane receptor normally found on intestinal + cells and dopamine neurons in the brain, but is also overexpressed on the surface + of gastrointestinal cancers. Upon internalization and proteolytic cleavage, + MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase + arrest and tumor cell apoptosis in GCC-expressing tumor cells. + termDef: + term: >- + Indusatumab Vedotin + source: NCIt + cde_id: C101524 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101524" + term_id: C101524 + term_version: 20.10d + +inebilizumab: + common: + description: >- + A humanized immunoglobulin IgG1 kappa monoclonal antibody directed against the + B-cell-specific membrane protein CD-19 with potential immunostimulating and + antineoplastic activities. Inebilizumab binds to CD19, which may result in a + cytotoxic T-lymphocyte (CTL) response and antibody-dependent cellular cytotoxicity + (ADCC) to CD19-expressing B-cells. The Fc portion of inebilizumab does not contain + a fucose sugar moiety, which may contribute to its enhanced ADCC activity. CD19 + is a membrane antigen that is widely expressed during B-cell development, from + pro-B-cell to early plasma cell stages. + termDef: + term: >- + Inebilizumab + source: NCIt + cde_id: C88283 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C88283" + term_id: C88283 + term_version: 20.10d + +infantile_fibrosarcoma: + common: + description: >- + A fibrosarcoma that occurs in infants. It shares identical morphologic features + with adult fibrosarcoma but carries the t(12;15)(p13;q25) translocation that + results in ETV6-NTRK3 gene fusion. It usually affects the superficial and deep + soft tissues of the extremities. The prognosis is generally much more favorable + than for adult fibrosarcoma, and it rarely metastasizes. + termDef: + term: >- + Infantile Fibrosarcoma + source: NCIt + cde_id: C4244 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4244" + term_id: C4244 + term_version: 20.05a + +infantile_hemangioma: + common: + description: >- + A capillary hemangioma that may regress spontaneously. It occurs in infants + and children. + termDef: + term: >- + Infantile Hemangioma + source: NCIt + cde_id: C6645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6645" + term_id: C6645 + term_version: 20.05a + +infantile_myofibromatosis: + common: + description: >- + A benign, multifocal, nodular and well-circumscribed neoplasm usually seen as + a congenital neoplasm or in the first year of life. It is characterized by a + biphasic growth pattern and is composed of small, undifferentiated mesenchymal + cells associated with branching thin-walled vessels and more mature neoplastic + spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma. + termDef: + term: >- + Myofibromatosis + source: NCIt + cde_id: C3742 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3742" + term_id: C3742 + term_version: 20.05a + +infection: + common: + description: >- + A disorder resulting from the presence and activity of a microbial, viral, fungal, + or parasitic agent. It can be transmitted by direct or indirect contact. + termDef: + term: >- + Infectious Disorder + source: NCIt + cde_id: C26726 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26726" + term_id: C26726 + term_version: 19.12e + +infiltrating_and_papillary_adenocarcinoma: + common: + description: >- + A carcinoma that has papillary growth and invades the wall and/or the surrounding + tissues of the organ it originates from. + termDef: + term: >- + Infiltrating Papillary Adenocarcinoma + source: NCIt + cde_id: C7438 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7438" + term_id: C7438 + term_version: 20.05a + +infiltrating_angiolipoma: + common: + description: >- + An uncommon lipoma characterized by prominent vascularity that invades the surrounding + deep tissue. + termDef: + term: >- + Infiltrating Angiolipoma + source: NCIt + cde_id: C7449 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7449" + term_id: C7449 + term_version: 20.05a + +infiltrating_basal_cell_carcinoma_nonsclerosing: + common: + description: >- + A variant of basal cell carcinoma presenting as a pale, indurated plaque, usually + in the upper trunk or face. Morphologically, it is characterized by the presence + of strands, cords, and columns of basaloid cells infiltrating the dermis. Perineural + invasion may be present and the basaloid cell infiltrate may extend into deeper + tissues. + termDef: + term: >- + Skin Infiltrating Basal Cell Carcinoma + source: NCIt + cde_id: C27539 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27539" + term_id: C27539 + term_version: 20.05a + +infiltrating_basal_cell_carcinoma_nos: + common: + description: >- + A variant of basal cell carcinoma presenting as a pale, indurated plaque, usually + in the upper trunk or face. Morphologically, it is characterized by the presence + of strands, cords, and columns of basaloid cells infiltrating the dermis. Perineural + invasion may be present and the basaloid cell infiltrate may extend into deeper + tissues. + termDef: + term: >- + Skin Infiltrating Basal Cell Carcinoma + source: NCIt + cde_id: C27539 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27539" + term_id: C27539 + term_version: 20.05a + +infiltrating_basal_cell_carcinoma_sclerosing: + common: + description: >- + A histologic variant of basal cell carcinoma of the skin characterized by the + presence of strands and nests of malignant cells that are embedded in a dense + fibrotic stroma. + termDef: + term: >- + Skin Sclerosing/Morphoeic Basal Cell Carcinoma + source: NCIt + cde_id: C27182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27182" + term_id: C27182 + term_version: 20.05a + +infiltrating_duct_adenocarcinoma: + common: + description: >- + The most common type of invasive breast carcinoma, accounting for approximately + 70% of breast carcinomas. The gross appearance is usually typical with an irregular + stellate outline. Microscopically, randomly arranged epithelial elements are + seen. When large sheets of malignant cells are present, necrosis may be seen. With + adequate tissue sampling, in situ carcinoma can be demonstrated in association + with the infiltrating carcinoma. The in situ component is nearly always ductal + but occasionally may be lobular or both. + termDef: + term: >- + Invasive Ductal Carcinoma, Not Otherwise Specified + source: NCIt + cde_id: C4194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4194" + term_id: C4194 + term_version: 20.05a + +infiltrating_duct_and_lobular_carcinoma: + common: + description: >- + An invasive ductal breast carcinoma associated with a lobular carcinomatous + component. The lobular carcinomatous component may be in situ or invasive. + termDef: + term: >- + Invasive Ductal and Lobular Carcinoma + source: NCIt + cde_id: C7688 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7688" + term_id: C7688 + term_version: 20.05a + +infiltrating_duct_and_lobular_carcinoma_in_situ: + common: + description: >- + An invasive ductal breast carcinoma associated with an in situ lobular carcinomatous + component. + termDef: + term: >- + Invasive Ductal and Lobular Carcinoma In Situ + source: NCIt + cde_id: C7689 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7689" + term_id: C7689 + term_version: 20.05a + +infiltrating_duct_carcinoma_nos: + common: + description: >- + The most common type of invasive breast carcinoma, accounting for approximately + 70% of breast carcinomas. The gross appearance is usually typical with an irregular + stellate outline. Microscopically, randomly arranged epithelial elements are + seen. When large sheets of malignant cells are present, necrosis may be seen. With + adequate tissue sampling, in situ carcinoma can be demonstrated in association + with the infiltrating carcinoma. The in situ component is nearly always ductal + but occasionally may be lobular or both. + termDef: + term: >- + Invasive Ductal Carcinoma, Not Otherwise Specified + source: NCIt + cde_id: C4194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4194" + term_id: C4194 + term_version: 20.05a + +infiltrating_ductular_carcinoma: + common: + description: >- + The most common type of invasive breast carcinoma, accounting for approximately + 70% of breast carcinomas. The gross appearance is usually typical with an irregular + stellate outline. Microscopically, randomly arranged epithelial elements are + seen. When large sheets of malignant cells are present, necrosis may be seen. With + adequate tissue sampling, in situ carcinoma can be demonstrated in association + with the infiltrating carcinoma. The in situ component is nearly always ductal + but occasionally may be lobular or both. + termDef: + term: >- + Invasive Ductal Carcinoma, Not Otherwise Specified + source: NCIt + cde_id: C4194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4194" + term_id: C4194 + term_version: 20.05a + +infiltrating_lipoma: + common: + description: >- + A benign tumor, composed of lobules of mature adipocytes, that penetrates the + surrounding tissue from which it arises. There is usually a higher local recurrence + rate when compared with non-infiltrating lipomas. + termDef: + term: >- + Infiltrating Lipoma + source: NCIt + cde_id: C7451 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7451" + term_id: C7451 + term_version: 20.05a + +infiltrating_lobular_carcinoma_and_ductal_carcinoma_in_situ: + common: + description: >- + A breast carcinoma characterized by the presence of a ductal carcinoma in situ + component and an invasive lobular carcinomatous component. + termDef: + term: >- + Ductal Breast Carcinoma In Situ and Invasive Lobular Carcinoma + source: NCIt + cde_id: C6939 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6939" + term_id: C6939 + term_version: 20.05a + +infiltrating_lobular_carcinoma_nos: + common: + description: >- + An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack + cohesion and are arranged individually or in a linear manner (Indian files), + or as narrow trabeculae within the stroma. The malignant cells are usually + smaller than those of ductal carcinoma, are less pleomorphic, and have fewer + mitotic figures. + termDef: + term: >- + Invasive Lobular Breast Carcinoma + source: NCIt + cde_id: C7950 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7950" + term_id: C7950 + term_version: 20.05a + +infiltrating_papillary_adenocarcinoma: + common: + description: >- + A carcinoma that has papillary growth and invades the wall and/or the surrounding + tissues of the organ it originates from. + termDef: + term: >- + Infiltrating Papillary Adenocarcinoma + source: NCIt + cde_id: C7438 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7438" + term_id: C7438 + term_version: 20.05a + +inflammatory_liposarcoma: + common: + description: >- + A rare morphologic variant of well differentiated liposarcoma occurring most + often in the retroperitoneum. It is characterized by the presence of a predominant + inflammatory infiltrate composed of lymphoplasmacytic aggregates. + termDef: + term: >- + Inflammatory Liposarcoma + source: NCIt + cde_id: C6508 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6508" + term_id: C6508 + term_version: 20.05a + +inflammatory_myofibroblastic_tumor: + common: + description: >- + A multinodular intermediate fibroblastic neoplasm that arises from soft tissue + or viscera, in children and young adults. It is characterized by the presence + of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory + infiltrate composed of eosinophils, lymphocytes, and plasma cells. + termDef: + term: >- + Inflammatory Myofibroblastic Tumor + source: NCIt + cde_id: C6481 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6481" + term_id: C6481 + term_version: 20.05a + +inframe_deletion: + common: + description: >- + A loss of three consecutive nucleotides (one codon) or multiple codons in a + gene that encodes for a protein where one or more canonical amino acids are + deleted but does not result in a frameshift mutation. + termDef: + term: >- + Inframe Deletion + source: NCIt + cde_id: C165225 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165225" + term_id: C165225 + term_version: 20.10d + +inframe_insertion: + common: + description: >- + A gain of three consecutive nucleotides (one codon) or multiple codons in a + gene that encodes for a protein where one or more non-wildtype amino acids are + inserted but does not result in a frameshift mutation. + termDef: + term: >- + Inframe Insertion + source: NCIt + cde_id: C165226 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165226" + term_id: C165226 + term_version: 20.10d + +inguinal: + common: + description: >- + A superficial or deep lymph node located in the inguinal area. + termDef: + term: >- + Inguinal Lymph Node + source: NCIt + cde_id: C32801 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32801" + term_id: C32801 + term_version: 20.10d + +inkt_cell_agonist_abx196: + common: + description: >- + A synthetic glycolipid agonist for natural killer T-cells (NKTs) expressing + an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating + and antineoplastic activities. Upon infusion of the iNKT cell agonist ABX196, + this agent targets and binds to iNKTs, thereby activating iNKTs. In turn, iNKTs + recognize CD1d-restricted lipid ligands, which are expressed on certain tumor + cells, and secrete large amounts of various cytokines. This may activate the + immune system against tumor cells. Additionally, iNKTs directly target and lyse + tumor cells. + termDef: + term: >- + iNKT Cell Agonist ABX196 + source: NCIt + cde_id: C172187 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172187" + term_id: C172187 + term_version: 20.10d + +insertion: + common: + description: >- + Any rearrangement to the genomic content that adds one or more extra nucleotides + into the DNA. Insertions may be reversible, particulary if caused by transposable + elements. They may alter the reading frame of a gene, or may cause large scale + additions of genomic DNA. + termDef: + term: >- + Insertion Mutation + source: NCIt + cde_id: C19295 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19295" + term_id: C19295 + term_version: 20.10d + +insular_carcinoma: + common: + description: >- + An adenocarcinoma arising from the thyroid gland showing only limited evidence + of follicular cell differentiation. Microscopically, the adenocarcinoma cells + are arranged in insular, solid, and trabecular patterns. There is associated + necrosis, and vascular invasion. The prognosis depends on the tumor stage, complete + or partial surgical removal of the tumor, and the degree of response to radioactive + iodine therapy. (adapted from WHO Tumors of Endocrine Organs, IARC Press, Lyon + 2004) + termDef: + term: >- + Poorly Differentiated Thyroid Gland Carcinoma + source: NCIt + cde_id: C6040 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6040" + term_id: C6040 + term_version: 20.05a + +insulinoma_malignant: + common: + description: >- + An insulin-producing neuroendocrine tumor arising from the beta cells of the + pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate + secretion of insulin. It displays vascular invasion and metastasizes to other + anatomic sites. + termDef: + term: >- + Malignant Pancreatic Insulinoma + source: NCIt + cde_id: C65186 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65186" + term_id: C65186 + term_version: 20.05a + +insulinoma_nos: + common: + description: >- + An insulin-producing neuroendocrine tumor arising from the beta cells of the + pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate + secretion of insulin. + termDef: + term: >- + Pancreatic Insulinoma + source: NCIt + cde_id: C95598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95598" + term_id: C95598 + term_version: 20.05a + +interdigitating_cell_sarcoma: + common: + description: >- + A neoplastic proliferation of spindle to ovoid cells which show phenotypic features + similar to those of interdigitating dendritic cells. The clinical course is + generally aggressive. (WHO, 2008) + termDef: + term: >- + Interdigitating Dendritic Cell Sarcoma + source: NCIt + cde_id: C9282 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9282" + term_id: C9282 + term_version: 20.05a + +interdigitating_dendritic_cell_sarcoma: + common: + description: >- + A neoplastic proliferation of spindle to ovoid cells which show phenotypic features + similar to those of interdigitating dendritic cells. The clinical course is + generally aggressive. (WHO, 2008) + termDef: + term: >- + Interdigitating Dendritic Cell Sarcoma + source: NCIt + cde_id: C9282 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9282" + term_id: C9282 + term_version: 20.05a + +intergenic_variant: + common: + description: >- + A change in the nucleotide sequence of a region between gene loci. + termDef: + term: >- + Intergenic Mutation + source: NCIt + cde_id: C148642 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148642" + term_id: C148642 + term_version: 20.10d + +interleukin12fc_fusion_protein_df6002: + common: + description: >- + A fusion protein composed of human interleukin-12 (IL-12) fused to a Fc fragment, + with potential immunomodulatory and antineoplastic activities. Upon administration + of IL-12-Fc fusion protein DF6002, the IL-12 moiety binds to the IL-12 receptor. + This may activate the immune system by promoting the secretion of interferon-gamma, + activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) + responses, which may result in both decreased tumor cell proliferation and enhanced + immune-mediated destruction of tumor cells. + termDef: + term: >- + Interleukin-12-Fc Fusion Protein DF6002 + source: NCIt + cde_id: C173371 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173371" + term_id: C173371 + term_version: 20.10d + +interleukin15_agonist_fusion_protein_shr1501: + common: + description: >- + A human Fc fusion protein composed of the cytokine interleukin (IL)-15 cross-linked + with the high-affinity binding sushi domain of IL-15 receptor alpha (IL-15Ra), + with potential antineoplastic activity. Upon administration, SHR-1501 activates + and increases the levels of natural killer (NK) cells and memory CD8+ T-cells + without stimulating regulatory T-cells (Tregs). The memory T-cells enhance the + secretion of the cytokine interferon-gamma (IFN-g), which further potentiates + the immune response against tumor cells. This may increase tumor cell killing + and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, + activation and proliferation. SHR1501 is more potent than unmodified IL-15 and + does not require endogenous IL-15Ra for its action. The Fc moiety allows for + an extended half-life of SHR-1501 while cross linking IL-15 with IL-15Ra sushi + domain improves stability. + termDef: + term: >- + Interleukin-15 Agonist Fusion Protein SHR1501 + source: NCIt + cde_id: C171385 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171385" + term_id: C171385 + term_version: 20.10d + +interleukin15_fusion_protein_bj001: + common: + description: >- + A human fusion protein composed of the cytokine interleukin (IL)-15 linked with + an integrins-targeting moiety, with potential antineoplastic activity. Upon + subcutaneous administration, the integrins-targeting moiety of BJ-001 targets + tumor cells that overexpress integrins such as alpha v beta 3 (avb3), alpha + v beta 5 (avb5) and alpha v beta 6 (avb6) and the IL-15 moiety binds to the + IL-2/IL-15 receptor beta-common gamma chain (IL-2Rbetagamma) receptor on natural + killer (NK) cells and CD8+ T-lymphocytes. This activates and increases the levels + of NK cells and memory CD8+ T-cells. The memory T-cells enhance the secretion + of the cytokine interferon-gamma (IFN-g), which further potentiates the immune + response against tumor cells. This may increase tumor cell killing and decrease + tumor cell proliferation. IL-15 regulates CD8+ T- and NK cell development, activation + and proliferation. Integrins are involved in tumor growth, angiogenesis, and + metastasis and they are overexpressed in a variety of tumor cell types. The + linkage of the two moieties may limit the effects of IL-15 to the local tumor + microenvironment (TME), increasing efficacy while reducing systemic toxicities. + termDef: + term: >- + Interleukin-15 Fusion Protein BJ-001 + source: NCIt + cde_id: C172075 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172075" + term_id: C172075 + term_version: 20.10d + +interleukin15interleukin15_receptor_alpha_complexfc_fusion_protein_xmab24306: + common: + description: >- + An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific + Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306 + stimulates the proliferation of natural killer (NK) cells and memory CD8+ T-cells. + The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), + which further potentiates the immune response against tumor cells. This may + increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates + CD8+ T and NK cell development, activation and proliferation. XmAb24306 does + not require endogenous IL-15Ra for its activation. + termDef: + term: >- + Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306 + source: NCIt + cde_id: C170890 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170890" + term_id: C170890 + term_version: 20.10d + +interleukin15interleukin15_receptor_alpha_sushi_domain_fusion_protein_soc101: + common: + description: >- + A human fusion protein consisting of the cytokine interleukin (IL)-15 and the + high-affinity binding sushi+ domain of IL-15 receptor alpha (IL-15Ra), with + potential antineoplastic activities. Upon administration, SO-C101 activates + and increases the levels of natural killer (NK) cells and memory CD8+ T-cells. + The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), + which further potentiates the immune response against tumor cells. This may + increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates + CD8+ T and NK cell development, activation and proliferation. SO-C101 is more + potent than unmodified IL-15 and does not require endogenous IL-15Ra for its + action. + termDef: + term: >- + Interleukin-15/Interleukin-15 Receptor Alpha Sushi+ Domain Fusion Protein + SO-C101 + source: NCIt + cde_id: C170516 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170516" + term_id: C170516 + term_version: 20.10d + +intermediate: + common: + description: >- + Lying between two extremes in time or space or degree. + termDef: + term: >- + Intermediate + source: NCIt + cde_id: C73705 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73705" + term_id: C73705 + term_version: 20.05a + +intermediate_grade: + common: + description: >- + A term referring to the degree of differentiation of a malignant neoplasm and + indicating that it is moderately differentiated. + termDef: + term: >- + Intermediate Grade + source: NCIt + cde_id: C28083 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28083" + term_id: C28083 + term_version: 20.05a + +intermediate_risk: + common: + description: >- + The potential future harm that may arise from some present action or attribute + or condition is moderate. + termDef: + term: >- + Intermediate Risk + source: NCIt + cde_id: C102402 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102402" + term_id: C102402 + term_version: 20.05a + +interstitial_cell_tumor_benign: + common: + description: >- + A Leydig cell tumor which does not recur or metastasize. Morphologically, there + is no evidence of cellular atypia, increased mitotic activity, necrosis, or + vascular invasion. + termDef: + term: >- + Benign Leydig Cell Tumor + source: NCIt + cde_id: C4212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4212" + term_id: C4212 + term_version: 20.05a + +interstitial_cell_tumor_malignant: + common: + description: >- + A Leydig cell tumor characterized by large tumor size, the presence of cytologic + atypia, increased mitotic activity, necrosis, and vascular invasion. Approximately + 10% of the testicular Leydig cell tumors show malignant characteristics and + metastasize. Leydig cell tumors of the ovary follow a benign clinical course. + termDef: + term: >- + Malignant Leydig Cell Tumor + source: NCIt + cde_id: C4213 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4213" + term_id: C4213 + term_version: 20.05a + +interstitial_cell_tumor_nos: + common: + description: >- + A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It + is predominantly or completely composed of Leydig cells which may contain crystals + of Reinke. In males it usually presents as a painless testicular enlargement + and it may be associated with gynecomastia and decreased libido. The majority + of the cases have a benign clinical course. Approximately 10% of the cases have + a malignant clinical course and metastasize. In females it may be associated + with androgenic manifestations and it follows a benign clinical course. + termDef: + term: >- + Leydig Cell Tumor + source: NCIt + cde_id: C3188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3188" + term_id: C3188 + term_version: 20.05a + +intestinal_tcell_lymphoma: + common: + description: >- + A mature T-cell and NK-cell non-Hodgkin lymphoma of intraepithelial T-lymphocytes. + It usually arises from the small intestine, most commonly the jejunum or ileum. Other + less frequent primary anatomic sites include the duodenum, stomach, colon, or + outside the gastrointestinal tract. It is characterized by the presence of pleomorphic + medium-sized to large T-lymphocytes with vesicular nuclei, prominent nucleoli, + and moderate to abundant pale cytoplasm. It is associated with celiac disease. + termDef: + term: >- + Enteropathy-Associated T-Cell Lymphoma + source: NCIt + cde_id: C4737 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4737" + term_id: C4737 + term_version: 20.05a + +intestinal_tract_nos: + common: + description: >- + The portion of the gastrointestinal tract between the stomach and the anus. + It includes the small intestine and large intestine. + termDef: + term: >- + Intestine + source: NCIt + cde_id: C12736 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12736" + term_id: C12736 + term_version: 20.05a + +intestinaltype_adenocarcinoma: + common: + description: >- + An adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. + Representative examples include gastric, gallbladder, and ampulla of Vater intestinal + type adenocarcinomas. + termDef: + term: >- + Intestinal-Type Adenocarcinoma + source: NCIt + cde_id: C4126 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4126" + term_id: C4126 + term_version: 20.05a + +intimal_sarcoma: + common: + description: >- + A malignant neoplasm arising from the large blood vessels. It is characterized + by the presence of tumor cells that grow within the lumen of the blood vessels. The + intraluminal tumor growth may result in vascular obstruction and spread of tumor + emboli to peripheral organs. The prognosis is usually poor. + termDef: + term: >- + Intimal Sarcoma + source: NCIt + cde_id: C53677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53677" + term_id: C53677 + term_version: 20.05a + +intraabdominal_lymph_nodes: + common: + description: >- + Any lymph node within the abdomen. + termDef: + term: >- + Intra-Abdominal Lymph Node + source: NCIt + cde_id: C12360 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12360" + term_id: C12360 + term_version: 20.05a + +intracanalicular_fibroadenoma: + common: + description: >- + A morphologic variant of breast fibroadenoma without clinical significance. + It is characterized by distortion and compression of the ducts by proliferating + stromal cells. + termDef: + term: >- + Breast Intracanalicular Fibroadenoma + source: NCIt + cde_id: C4271 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4271" + term_id: C4271 + term_version: 20.05a + +intracompartmental_t1: + common: + description: >- + Bone tumors are confined within the cortex of the bone. + termDef: + term: >- + Intracompartmental Tumor + source: NCIt + cde_id: C140263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140263" + term_id: C140263 + term_version: 20.05a + +intracortical_osteosarcoma: + common: + description: >- + A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. + The tumor arises from the medullary portion of the bone. It affects the long + bones and most commonly, the distal femur, proximal tibia, and proximal humerus. + Pain with or without a palpable mass is the most common clinical presentation. + It usually has an aggressive growth and may metastasize through the hematogenous + route. The lung is the most frequent site of metastasis. + termDef: + term: >- + Conventional Osteosarcoma + source: NCIt + cde_id: C35870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35870" + term_id: C35870 + term_version: 20.05a + +intracystic_carcinoma_nos: + common: + description: >- + An intraductal breast carcinoma characterized by a papillary growth within a + large cystic duct. There is no evidence of invasion of the breast parenchyma. + termDef: + term: >- + Intracystic Papillary Breast Carcinoma + source: NCIt + cde_id: C7645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7645" + term_id: C7645 + term_version: 20.05a + +intracystic_papillary_adenocarcinoma: + common: + description: >- + An intraductal breast carcinoma characterized by a papillary growth within a + large cystic duct. There is no evidence of invasion of the breast parenchyma. + termDef: + term: >- + Intracystic Papillary Breast Carcinoma + source: NCIt + cde_id: C7645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7645" + term_id: C7645 + term_version: 20.05a + +intracystic_papillary_adenoma: + common: + description: >- + A papillary epithelial neoplasm arising in a cystically dilated breast duct. + termDef: + term: >- + Intracystic Papilloma + source: NCIt + cde_id: C4191 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4191" + term_id: C4191 + term_version: 20.05a + +intracystic_papillary_neoplasm_with_intermediate_grade_intraepithelial_neoplasia: + common: + description: >- + A non-invasive, papillary epithelial neoplasm that arises from the epithelium + of gallbladder. It is characterized by the presence of moderate epithelial + atypia. + termDef: + term: >- + Gallbladder Papillary Neoplasm with Intermediate Grade Intraepithelial Neoplasia + source: NCIt + cde_id: C96878 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96878" + term_id: C96878 + term_version: 20.05a + +intracystic_papillary_neoplasm_with_low_grade_intraepithelial_neoplasia: + common: + description: >- + A non-invasive, papillary epithelial neoplasm that arises from the epithelium + of the gallbladder. It is characterized by the presence of mild epithelial + atypia. + termDef: + term: >- + Gallbladder Papillary Neoplasm with Low Grade Intraepithelial Neoplasia + source: NCIt + cde_id: C96877 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96877" + term_id: C96877 + term_version: 20.05a + +intracystic_papilloma: + common: + description: >- + A papillary epithelial neoplasm arising in a cystically dilated breast duct. + termDef: + term: >- + Intracystic Papilloma + source: NCIt + cde_id: C4191 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4191" + term_id: C4191 + term_version: 20.05a + +intradermal_nevus: + common: + description: >- + A nevus characterized by the proliferation of nevus cells in the dermis without + involvement of the dermal-epidermal junction. + termDef: + term: >- + Dermal Nevus + source: NCIt + cde_id: C3804 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3804" + term_id: C3804 + term_version: 20.05a + +intraductal_adenocarcinoma_noninfiltrating_nos: + common: + description: >- + A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There + is no evidence of invasion of the basement membrane. Currently, it is classified + into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade + DCIS. In this classification the DCIS grade is defined by a combination of nuclear + grade, architectural growth pattern and presence of necrosis. The size of the + lesion as well as the grade and the clearance margins play a major role in dictating + the most appropriate therapy for DCIS. + termDef: + term: >- + Ductal Breast Carcinoma In Situ + source: NCIt + cde_id: C2924 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2924" + term_id: C2924 + term_version: 20.05a + +intraductal_and_lobular_carcinoma: + common: + description: >- + A breast carcinoma characterized by the presence of a ductal carcinoma in situ + component and an in situ or invasive lobular carcinomatous component. + termDef: + term: >- + Intraductal and Lobular Carcinoma + source: NCIt + cde_id: C7690 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7690" + term_id: C7690 + term_version: 20.05a + +intraductal_carcinoma_and_lobular_carcinoma_in_situ: + common: + description: >- + The co-existence of ductal and lobular carcinoma in situ in the breast, without + evidence of stromal invasion. + termDef: + term: >- + Ductal Breast Carcinoma In Situ and Lobular Carcinoma In Situ + source: NCIt + cde_id: C4195 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4195" + term_id: C4195 + term_version: 20.05a + +intraductal_carcinoma_noninfiltrating_nos: + common: + description: >- + A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There + is no evidence of invasion of the basement membrane. Currently, it is classified + into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade + DCIS. In this classification the DCIS grade is defined by a combination of nuclear + grade, architectural growth pattern and presence of necrosis. The size of the + lesion as well as the grade and the clearance margins play a major role in dictating + the most appropriate therapy for DCIS. + termDef: + term: >- + Ductal Breast Carcinoma In Situ + source: NCIt + cde_id: C2924 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2924" + term_id: C2924 + term_version: 20.05a + +intraductal_carcinoma_nos: + common: + description: >- + A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There + is no evidence of invasion of the basement membrane. Currently, it is classified + into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade + DCIS. In this classification the DCIS grade is defined by a combination of nuclear + grade, architectural growth pattern and presence of necrosis. The size of the + lesion as well as the grade and the clearance margins play a major role in dictating + the most appropriate therapy for DCIS. + termDef: + term: >- + Ductal Breast Carcinoma In Situ + source: NCIt + cde_id: C2924 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2924" + term_id: C2924 + term_version: 20.05a + +intraductal_papillary_adenocarcinoma_nos: + common: + description: >- + A non-invasive breast adenocarcinoma located in a distended duct. It is characterized + by the presence of papillary structures with fibrovascular stalks. In the absence + of ductal carcinoma in situ or invasive carcinoma in adjacent tissues, the prognosis + is usually favorable. + termDef: + term: >- + Intraductal Papillary Breast Carcinoma + source: NCIt + cde_id: C4190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4190" + term_id: C4190 + term_version: 20.05a + +intraductal_papillary_adenocarcinoma_with_invasion: + common: + description: >- + A breast adenocarcinoma characterized by the presence of an intraductal papillary + carcinomatous component and an invasive carcinomatous component. + termDef: + term: >- + Intraductal Papillary Adenocarcinoma with Invasion + source: NCIt + cde_id: C7439 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7439" + term_id: C7439 + term_version: 20.05a + +intraductal_papillary_carcinoma: + common: + description: >- + A non-invasive breast adenocarcinoma located in a distended duct. It is characterized + by the presence of papillary structures with fibrovascular stalks. In the absence + of ductal carcinoma in situ or invasive carcinoma in adjacent tissues, the prognosis + is usually favorable. + termDef: + term: >- + Intraductal Papillary Breast Carcinoma + source: NCIt + cde_id: C4190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4190" + term_id: C4190 + term_version: 20.05a + +intraductal_papillary_mucinous_neoplasm_ipmn_with_an_associated_invasive_carcinoma: + common: + description: >- + A pancreatic intraductal papillary mucinous neoplasm characterized by the presence + of a focal or multifocal invasive carcinomatous component. The invasive carcinoma + is either colloid or ductal adenocarcinoma. + termDef: + term: >- + Pancreatic Intraductal Papillary-Mucinous Neoplasm with an Associated Invasive + Carcinoma + source: NCIt + cde_id: C5726 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5726" + term_id: C5726 + term_version: 20.05a + +intraductal_papillary_mucinous_neoplasm_with_high_grade_dysplasia: + common: + description: >- + A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized + by the presence of neoplastic epithelial cells that exhibit loss of polarity, + nuclear stratification, hyperchromasia, and pleomorphism. There is severe architectural + atypia and frequent mitotic figures present. + termDef: + term: >- + Pancreatic Intraductal Papillary-Mucinous Neoplasm with High Grade Dysplasia + source: NCIt + cde_id: C41251 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C41251" + term_id: C41251 + term_version: 20.05a + +intraductal_papillary_neoplasm_nos: + common: + description: >- + A non-invasive, papillary epithelial neoplasm that arises from the epithelium + of the intrahepatic or extrahepatic bile ducts. + termDef: + term: >- + Bile Duct Papillary Neoplasm + source: NCIt + cde_id: C6881 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6881" + term_id: C6881 + term_version: 20.05a + +intraductal_papillary_neoplasm_with_associated_invasive_carcinoma: + common: + description: >- + A breast adenocarcinoma characterized by the presence of an intraductal papillary + carcinomatous component and an invasive carcinomatous component. + termDef: + term: >- + Intraductal Papillary Adenocarcinoma with Invasion + source: NCIt + cde_id: C7439 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7439" + term_id: C7439 + term_version: 20.05a + +intraductal_papillary_neoplasm_with_high_grade_intraepithelial_neoplasia: + common: + description: >- + A non-invasive, papillary epithelial neoplasm that arises from the epithelium + of the intrahepatic or extrahepatic bile ducts. It is characterized by the + presence of severe epithelial atypia. + termDef: + term: >- + Bile Duct Papillary Neoplasm with High Grade Intraepithelial Neoplasia + source: NCIt + cde_id: C96809 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96809" + term_id: C96809 + term_version: 20.05a + +intraductal_papillary_neoplasm_with_intermediate_grade_neoplasia: + common: + description: >- + An intraluminal papillary epithelial neoplasm arising within the ducts. Representative + examples are the intraductal breast papilloma and the salivary gland intraductal + papilloma. + termDef: + term: >- + Intraductal Papilloma + source: NCIt + cde_id: C3785 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3785" + term_id: C3785 + term_version: 20.05a + +intraductal_papillary_neoplasm_with_low_grade_intraepithelial_neoplasia: + common: + description: >- + A non-invasive, papillary epithelial neoplasm that arises from the epithelium + of the intrahepatic or extrahepatic bile ducts. It is characterized by the + presence of mild epithelial atypia. + termDef: + term: >- + Bile Duct Papillary Neoplasm with Low Grade Intraepithelial Neoplasia + source: NCIt + cde_id: C96807 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96807" + term_id: C96807 + term_version: 20.05a + +intraductal_papilloma: + common: + description: >- + An intraluminal papillary epithelial neoplasm arising within the ducts. Representative + examples are the intraductal breast papilloma and the salivary gland intraductal + papilloma. + termDef: + term: >- + Intraductal Papilloma + source: NCIt + cde_id: C3785 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3785" + term_id: C3785 + term_version: 20.05a + +intraductal_papillomatosis_nos: + common: + description: >- + A neoplastic process characterized by the presence of multiple intraductal papillomas. + termDef: + term: >- + Intraductal Papillomatosis + source: NCIt + cde_id: C7363 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7363" + term_id: C7363 + term_version: 20.05a + +intraductal_tubulopapillary_neoplasm: + common: + description: >- + An epithelial neoplasm that arises from the exocrine pancreas characterized + by the formation of tubular structures, high grade dysplasia, and ductal differentiation. + Grossly, it is characterized by the presence of intraductal nodular masses. + Morphologically, there are nodules of tubular glands and occasional papillary + structures growing in dilated ducts. There is no significant mucin production. + Signs and symptoms include epigastric pain, weight loss, vomiting, steatorrhea, + and diabetes mellitus. + termDef: + term: >- + Pancreatic Intraductal Tubulopapillary Neoplasm + source: NCIt + cde_id: C95506 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95506" + term_id: C95506 + term_version: 20.05a + +intraepidermal_carcinoma_nos: + common: + description: >- + A malignant epithelial neoplasm confined to the squamous epithelium, without + invasion of the underlying tissues. + termDef: + term: >- + Stage 0 Squamous Cell Carcinoma + source: NCIt + cde_id: C27093 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27093" + term_id: C27093 + term_version: 20.05a + +intraepidermal_epithelioma_of_jadassohn: + common: + description: >- + A rare cutaneous lesion presenting as a scaly verrucous plaque. Morphologically, + the plaque contains nests of basaloid cells. + termDef: + term: >- + Intraepidermal Epithelioma of Jadassohn + source: NCIt + cde_id: C4110 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4110" + term_id: C4110 + term_version: 20.05a + +intraepidermal_nevus: + common: + description: >- + A nevus characterized by the presence of an intraepidermal proliferation of + nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. + It presents as a small, slightly raised, pigmented skin lesion. + termDef: + term: >- + Junctional Nevus + source: NCIt + cde_id: C4231 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4231" + term_id: C4231 + term_version: 20.05a + +intraepidermal_squamous_cell_carcinoma_bowen_type: + common: + description: >- + A form of squamous cell carcinoma in situ. It is a distinct clinicopathological + entity and arises from the skin or the mucocutaneous junction. It affects predominantly + white males in their 6-8th decades of life. Exposed and non-exposed skin sites + are equally affected. UV damage and ingestion of inorganic arsenic may play + a role in the development of the disease. On the skin surface, it presents as + a single or multiple erythematous, scaly, keratotic patches or plaques. The + clinical entity of erythroplasia of Queyrat is regarded as Bowen disease of + the penis and it presents as an asymptomatic, red, circumscribed plaque. Morphologically, + Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, + dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and + display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement + membrane is intact. Complete surgical removal of the lesion may be curative. + termDef: + term: >- + Bowen Disease of the Skin + source: NCIt + cde_id: C62571 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62571" + term_id: C62571 + term_version: 20.05a + +intraepithelial_carcinoma_nos: + common: + description: >- + A malignant epithelial neoplasm which is confined to the epithelial layer without + evidence of further tissue invasion. + termDef: + term: >- + Carcinoma In Situ + source: NCIt + cde_id: C2917 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2917" + term_id: C2917 + term_version: 20.05a + +intraepithelial_squamous_cell_carcinoma: + common: + description: >- + A malignant epithelial neoplasm confined to the squamous epithelium, without + invasion of the underlying tissues. + termDef: + term: >- + Stage 0 Squamous Cell Carcinoma + source: NCIt + cde_id: C27093 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27093" + term_id: C27093 + term_version: 20.05a + +intraglandular_papillary_neoplasm_with_low_grade_intraepithelial_neoplasia: + common: + description: >- + An intraluminal papillary epithelial neoplasm arising within the ducts. Representative + examples are the intraductal breast papilloma and the salivary gland intraductal + papilloma. + termDef: + term: >- + Intraductal Papilloma + source: NCIt + cde_id: C3785 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3785" + term_id: C3785 + term_version: 20.05a + +intrahepatic_bile_duct: + common: + description: >- + The bile ducts which are located within the liver. They include the small interlobular + bile ducts, intrahepatic large bile ducts, and the intrahepatic portions of + the left and right hepatic ducts. + termDef: + term: >- + Intrahepatic Bile Duct + source: NCIt + cde_id: C12677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12677" + term_id: C12677 + term_version: 20.05a + +intramural: + common: + description: >- + Happening or arising or located within some limits, or especially, within some + surface. + termDef: + term: >- + Internal + source: NCIt + cde_id: C25234 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25234" + term_id: C25234 + term_version: 20.05a + +intramuscular_hemangioma: + common: + description: >- + A hemangioma arising from skeletal muscle. + termDef: + term: >- + Intramuscular Hemangioma + source: NCIt + cde_id: C3699 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3699" + term_id: C3699 + term_version: 20.05a + +intramuscular_lipoma: + common: + description: >- + A benign tumor, composed of mature adipocytes, that arises within skeletal muscle + fibers. + termDef: + term: >- + Intramuscular Lipoma + source: NCIt + cde_id: C7450 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7450" + term_id: C7450 + term_version: 20.05a + +intraneural_perineurioma: + common: + description: >- + A WHO grade I perineurioma that arises within the endoneurium. It is characterized + by the formation of pseudo-onion bulbs by the proliferating perineural cells. + termDef: + term: >- + Intraneural Perineurioma + source: NCIt + cde_id: C6911 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6911" + term_id: C6911 + term_version: 20.05a + +intraosseous_low_grade_osteosarcoma: + common: + description: >- + A low grade osteosarcoma arising from the medullary portion of the bone. It + affects the long bones and is characterized by the presence of fibroblastic + stroma and osteoid production. Pain and swelling are the usual sign and symptom. + The prognosis is more favorable than conventional osteosarcoma. + termDef: + term: >- + Low Grade Central Osteosarcoma + source: NCIt + cde_id: C6474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6474" + term_id: C6474 + term_version: 20.05a + +intraosseous_well_differentiated_osteosarcoma: + common: + description: >- + A low grade osteosarcoma arising from the medullary portion of the bone. It + affects the long bones and is characterized by the presence of fibroblastic + stroma and osteoid production. Pain and swelling are the usual sign and symptom. + The prognosis is more favorable than conventional osteosarcoma. + termDef: + term: >- + Low Grade Central Osteosarcoma + source: NCIt + cde_id: C6474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6474" + term_id: C6474 + term_version: 20.05a + +intrathoracic_lymph_nodes: + common: + description: >- + Any lymph node within the thoracic cavity. + termDef: + term: >- + Intrathoracic Lymph Node + source: NCIt + cde_id: C12359 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12359" + term_id: C12359 + term_version: 20.05a + +intravascular_bcell_lymphoma: + common: + description: >- + A rare extranodal B-cell non-Hodgkin lymphoma, characterized by the presence + of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries. This + is an extremely aggressive lymphoma which responds poorly to chemotherapy. (WHO, + 2001) + termDef: + term: >- + Intravascular Large B-Cell Lymphoma + source: NCIt + cde_id: C4342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4342" + term_id: C4342 + term_version: 20.05a + +intravascular_large_bcell_lymphoma: + common: + description: >- + A rare extranodal B-cell non-Hodgkin lymphoma, characterized by the presence + of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries. This + is an extremely aggressive lymphoma which responds poorly to chemotherapy. (WHO, + 2001) + termDef: + term: >- + Intravascular Large B-Cell Lymphoma + source: NCIt + cde_id: C4342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4342" + term_id: C4342 + term_version: 20.05a + +intron_variant: + common: + description: >- + Any mutation within an intron, including the sequences that comprise the intron + boundary. + termDef: + term: >- + Intronic Mutation + source: NCIt + cde_id: C63429 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63429" + term_id: C63429 + term_version: 20.10d + +invasive_encapsulated_follicular_variant_of_papillary_thyroid_carcinoma_invasive_efvptc: + common: + description: >- + A papillary carcinoma of the thyroid gland which is encapsulated and resembles + an encapsulated follicular neoplasm. Capsular invasion is present. The malignant + follicular cells display the nuclear features that characterize the papillary + adenocarcinomas of the thyroid gland. + termDef: + term: >- + Follicular Variant Thyroid Gland Papillary Carcinoma, Encapsulated Subtype + with Invasion + source: NCIt + cde_id: C66850 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66850" + term_id: C66850 + term_version: 20.05a + +invasive_fibroma: + common: + description: >- + An insidious, locally aggressive, poorly circumscribed neoplasm arising from + the deep soft tissues. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + It lacks metastatic potential. + termDef: + term: >- + Desmoid-Type Fibromatosis + source: NCIt + cde_id: C9182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9182" + term_id: C9182 + term_version: 20.05a + +invasive_hydatidiform_mole: + common: + description: >- + A complete hydatidiform mole or very rarely a partial mole that invades the + myometrium. + termDef: + term: >- + Invasive Hydatidiform Mole + source: NCIt + cde_id: C6985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6985" + term_id: C6985 + term_version: 20.05a + +invasive_lobular_carcinoma: + common: + description: >- + An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack + cohesion and are arranged individually or in a linear manner (Indian files), + or as narrow trabeculae within the stroma. The malignant cells are usually + smaller than those of ductal carcinoma, are less pleomorphic, and have fewer + mitotic figures. + termDef: + term: >- + Invasive Lobular Breast Carcinoma + source: NCIt + cde_id: C7950 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7950" + term_id: C7950 + term_version: 20.05a + +invasive_lobular_carcinoma_alveolar_type: + common: + description: >- + A grade I invasive lobular carcinoma of the breast, characterized by the presence + of round groups of neoplastic cells. + termDef: + term: >- + Invasive Lobular Breast Carcinoma, Alveolar Variant + source: NCIt + cde_id: C97049 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97049" + term_id: C97049 + term_version: 20.05a + +invasive_lobular_carcinoma_solid_type: + common: + description: >- + A grade I invasive lobular carcinoma of the breast, characterized by the presence + of neoplastic cells that form trabeculae and groups infiltrating collagen bundles. + termDef: + term: >- + Invasive Lobular Breast Carcinoma, Solid Variant + source: NCIt + cde_id: C97052 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97052" + term_id: C97052 + term_version: 20.05a + +invasive_lobular_carcinoma_tubulolobular_variant: + common: + description: >- + An invasive lobular carcinoma of the breast, characterized by the presence of + neoplastic cells forming small tubular structures. + termDef: + term: >- + Invasive Lobular Breast Carcinoma, Tubulolobular Variant + source: NCIt + cde_id: C97053 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97053" + term_id: C97053 + term_version: 20.05a + +invasive_mammary_carcinoma: + common: + description: >- + A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas + arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma + co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma + affecting women. + termDef: + term: >- + Invasive Breast Carcinoma + source: NCIt + cde_id: C9245 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9245" + term_id: C9245 + term_version: 20.05a + +invasive_micropapillary_carcinoma: + common: + description: >- + An invasive breast carcinoma characterized by the presence of clusters of malignant + cells located within artifactual clear stromal spaces that resemble vascular + spaces. + termDef: + term: >- + Invasive Micropapillary Breast Carcinoma + source: NCIt + cde_id: C36084 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36084" + term_id: C36084 + term_version: 20.05a + +invasive_mole_nos: + common: + description: >- + A complete hydatidiform mole or very rarely a partial mole that invades the + myometrium. + termDef: + term: >- + Invasive Hydatidiform Mole + source: NCIt + cde_id: C6985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6985" + term_id: C6985 + term_version: 20.05a + +invasive_mucinous_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma that arises from the lung. It is characterized by + the presence of tall columnar cells and mucin production. This category refers + to cases formerly classified as mucinous bronchioloalveolar carcinoma, excluding + cases that meet the criteria for adenocarcinoma in situ or mucinous minimally + invasive adenocarcinoma. + termDef: + term: >- + Invasive Lung Mucinous Adenocarcinoma + source: NCIt + cde_id: C136709 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C136709" + term_id: C136709 + term_version: 20.05a + +inversion: + common: + description: >- + A structural change in genomic DNA where the 5' to 3' order of a nucleotide + sequence is completely reversed to the 3' to 5' order relative to its adjacent + sequences. This inversion is termed either pericentric, if it includes the centromere + of a chromosome, or pancentric, if it excludes the centromere. An inversion + mutation abnormality may be heritable or occur somatically. + termDef: + term: >- + Inversion Mutation Abnormality + source: NCIt + cde_id: C45589 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45589" + term_id: C45589 + term_version: 20.10d + +involved: + common: + description: >- + Specifies whether the margins of surgical resection are infiltrated by disease. + termDef: + term: >- + Involved Surgical Margin Indicator + source: NCIt + cde_id: C93581 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93581" + term_id: C93581 + term_version: 20.10d + +iodine_i_131_apamistamab: + common: + description: >- + A radioimmunoconjugate consisting of BC8, a murine IgG1 anti-CD45 monoclonal + antibody labeled with iodine 131 (I-131), with radioimmunotherapeutic properties. + Using monoclonal antibody BC8 as a carrier for I-131 results in the targeted + destruction of cells expressing CD45. CD45 is tyrosine phosphatase expressed + on virtually all leukocytes, including myeloid and lymphoid precursors in bone + marrow and mature lymphocytes in lymph nodes; it is also expressed on most myeloid + and lymphoid leukemic cells, but not on mature erythrocytes or platelets. (NCI04) + termDef: + term: >- + Iodine I 131 Apamistamab + source: NCIt + cde_id: C2527 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2527" + term_id: C2527 + term_version: 20.10d + +iodine_i_131_ipa: + common: + description: >- + A radioconjugate consisting of the tumor-specific amino acid derivative 4-iodo-L-phenylalanine + labeled with iodine I 131, a beta emitting radionuclide, with potential antineoplastic + activity. Upon administration, iodine I 131 IPA actively crosses the blood-brain + barrier and accumulates specifically in gliomas, via the amino acid transport + system l-amino acid transporter 1 (LAT1) over-expressed in malignant glioma + cells. where it delivers a cytotoxic dose of beta radiation. Cells that are + exposed to radiation may also release potent toxins into the intracellular environment, + leading to radiation-induced biological bystander effects (RIBBE) and killing + cells not directly exposed to the radiation. Iodine I 131 IPA may also act synergistically + with external irradiation due to its radiosensitizing property. + termDef: + term: >- + Iodine I 131 IPA + source: NCIt + cde_id: C171348 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171348" + term_id: C171348 + term_version: 20.10d + +ipdimmunoprogression: + common: + description: >- + A marked increase in contrast enhancement that is not due to actual tumor growth, + but that may be due to a reaction to immunotherapy. + termDef: + term: >- + Immunoprogression + source: NCIt + cde_id: C131143 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131143" + term_id: C131143 + term_version: 20.05a + +ipscderived_cd16il15rfexpressing_anticd19_carnk_cells_ft596: + common: + description: >- + An allogeneic, off-the-shelf, chimeric antigen receptor (CAR)-natural killer + (NK) cell product derived from a clonal master induced pluripotent stem cell + (iPSC) line, and engineered to express a NK cell-specific anti-CD19 CAR, a high-affinity, + non-cleavable CD16 (hnCD16) Fc receptor, and a recombinant fusion of IL-15 and + IL-15 receptor alpha (IL-15RF), with potential immunostimulatory and antineoplastic + activities. Upon administration, iPSC-derived CD16/IL-15RF-expressing Anti-CD19 + CAR-NK Cells FT596 recognize, bind to and induce selective cytotoxicity in CD19-expressing + tumor cells. IL-15RF enhances the cytotoxic effect of the NK cells and the activated + anti-tumor T-cells. When used in combination with monoclonal antibodies, the + hnCD16 Fc receptor of FT596 binds to the Fc portion of tumor cell-bound monoclonal + antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent + cellular cytotoxicity (ADCC). CD19 antigen is a B-cell specific cell surface + antigen expressed in all B-cell lineage malignancies. CD16, also known as Fc-gamma + receptor III, is normally expressed on the surface of NK cells, neutrophils, + monocytes and macrophages, and plays a key role in initiating ADCC. It is often + downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. + termDef: + term: >- + iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596 + source: NCIt + cde_id: C170800 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170800" + term_id: C170800 + term_version: 20.10d + +iran: + common: + description: >- + A country in the Middle East, bordering the Gulf of Oman, the Persian Gulf, + and the Caspian Sea, between Iraq and Pakistan. + termDef: + term: >- + Iran + source: NCIt + cde_id: C16755 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16755" + term_id: C16755 + term_version: 19.12e + +iraq: + common: + description: >- + A country in the Middle East, bordering the Persian Gulf, between Iran and Syria. + termDef: + term: >- + Iraq + source: NCIt + cde_id: C16756 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16756" + term_id: C16756 + term_version: 19.12e + +ireland: + common: + description: >- + A country in western Europe, occupying five-sixths of the island of Ireland + in the North Atlantic Ocean, west of Great Britain. + termDef: + term: >- + Ireland + source: NCIt + cde_id: C16757 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16757" + term_id: C16757 + term_version: 19.12e + +irf4: + common: + description: >- + This gene is involved in the regulation of B-cell differentiation and proliferation. + It also plays a role in mediating the proliferation of mitogen-stimulated T + cells. + termDef: + term: >- + IRF4 Gene + source: NCIt + cde_id: C18430 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18430" + term_id: C18430 + term_version: 20.10d + +irinotecan_sucrosofate: + common: + description: >- + A liposomal formulation of the semisynthetic camptothecin analogue irinotecan + with potential antineoplastic activity. During the S phase of the cell cycle, + irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting + religation of topoisomerase I-mediated single-strand DNA breaks and producing + lethal double-strand DNA breaks when complexes are encountered by the DNA replication + machinery. Liposome encapsulation of this agent promotes efficient drug delivery + into the cytosol from the endosome compartment of the cell. + termDef: + term: >- + Irinotecan Sucrosofate + source: NCIt + cde_id: C82676 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82676" + term_id: C82676 + term_version: 20.10d + +iroplact: + common: + description: >- + A recombinant form of the endogenous chemokine platelet factor 4 with potential + antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, + iroplact inhibits growth factor-stimulated endothelial cell proliferation, migration, + and angiogenesis; it has been shown that this agent inhibits fibroblast growth + factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity + is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit + the proliferation of some tumor cell types. + termDef: + term: >- + Iroplact + source: NCIt + cde_id: C2251 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2251" + term_id: C2251 + term_version: 20.10d + +irradiated_allogeneic_human_lung_cancer_cells_expressing_ox40lig_vaccine_hs130: + common: + description: >- + An allogeneic irradiated human lung cancer cell vaccine expressing a fusion + protein composed of the OX40 ligand (OX40L) linked to an immunoglobulin (Ig) + (OX40L-Ig), with potential immunomodulating and antineoplastic activities. Upon + intradermal administration of irradiated allogeneic human lung cancer cells + expressing OX40L-Ig vaccine HS-130, the irradiated lung cancer cells continuously + express OX40L-Ig. OX40L may then target, bind to and activate its cognate receptor, + tumor necrosis factor receptor superfamily member 4 (TNFRSF4; OX40; CD134), + which is expressed on activated T-cells. OX40L/OX40 binding promotes increased + cytokine production, and induces the proliferation and activation of memory + and effector T-lymphocytes against the human lung cancer cells. In turn, this + promotes a CTL-mediated immune response against the endogenous lung cancer cells. + OX40L, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) + ligand family, provides a co-stimulatory signal for the proliferation and survival + of activated T-cells. + termDef: + term: >- + Irradiated Allogeneic Human Lung Cancer Cells Expressing OX40L-Ig Vaccine + HS-130 + source: NCIt + cde_id: C165639 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165639" + term_id: C165639 + term_version: 20.10d + +irs4: + common: + description: >- + This gene plays a role in signal transduction and ligand binding. + termDef: + term: >- + IRS4 Gene + source: NCIt + cde_id: C24524 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24524" + term_id: C24524 + term_version: 20.10d + +ish: + common: + description: >- + Use of a DNA or RNA probe to detect the presence of complementary sequences + in chromosomes, cells, or tissues. + termDef: + term: >- + In Situ Hybridization + source: NCIt + cde_id: C17562 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17562" + term_id: C17562 + term_version: 20.10d + +isle_of_man: + common: + description: >- + An island in the Irish Sea, between Great Britain and Ireland. + termDef: + term: >- + Isle of Man + source: NCIt + cde_id: C44480 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C44480" + term_id: C44480 + term_version: 19.12e + +islet_cell_adenocarcinoma: + common: + description: >- + An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine + differentiation that arises from the pancreas. The mitotic count is more than + 20 per 10 HPF. According to the size of the malignant cells, the prominence + of the nucleoli, and the amount of cytoplasm, it is classified either as small + or large cell neuroendocrine carcinoma. + termDef: + term: >- + Pancreatic Neuroendocrine Carcinoma + source: NCIt + cde_id: C3770 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3770" + term_id: C3770 + term_version: 20.05a + +islet_cell_adenoma: + common: + description: >- + A benign endocrine neoplasm arising from the pancreas. It is separated from + the normal pancreatic tissues by a thin collagenous capsule. It may secrete + a hormone (e.g. insulin, gastrin) or it may be non-functional. + termDef: + term: >- + Islet Cell Adenoma + source: NCIt + cde_id: C65184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65184" + term_id: C65184 + term_version: 20.05a + +islet_cell_adenomatosis: + common: + description: >- + A sporadic or inherited disorder characterized by the focal or diffuse proliferation + of the cells of the islets of Langerhans in the pancreas. It results in hyperinsulinemia + and hypoglycemia. + termDef: + term: >- + Nesidioblastosis + source: NCIt + cde_id: C4375 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4375" + term_id: C4375 + term_version: 20.05a + +islet_cell_carcinoma: + common: + description: >- + An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine + differentiation that arises from the pancreas. The mitotic count is more than + 20 per 10 HPF. According to the size of the malignant cells, the prominence + of the nucleoli, and the amount of cytoplasm, it is classified either as small + or large cell neuroendocrine carcinoma. + termDef: + term: >- + Pancreatic Neuroendocrine Carcinoma + source: NCIt + cde_id: C3770 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3770" + term_id: C3770 + term_version: 20.05a + +islet_cell_tumor_nos: + common: + description: >- + A neoplasm with neuroendocrine differentiation that arises from the pancreas. It + includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine + carcinomas (high grade). + termDef: + term: >- + Pancreatic Neuroendocrine Neoplasm + source: NCIt + cde_id: C27031 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27031" + term_id: C27031 + term_version: 20.05a + +islets_of_langerhans: + common: + description: >- + The pancreatic tissue that contains the islets of Langerhans. It is responsible + for the production and secretions of the pancreatic hormones. + termDef: + term: >- + Islet of Langerhans + source: NCIt + cde_id: C12608 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12608" + term_id: C12608 + term_version: 20.05a + +israel: + common: + description: >- + A country in the Middle East, bordering the Mediterranean Sea, between Egypt + and Lebanon. + termDef: + term: >- + Israel + source: NCIt + cde_id: C16760 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16760" + term_id: C16760 + term_version: 19.12e + +isthmus_uteri: + common: + description: >- + An elongated constriction of the lower part of the uterus, located at the junction + of the body of the uterus and the cervix, that is composed principally of smooth + muscle. + termDef: + term: >- + Isthmus Uteri + source: NCIt + cde_id: C12312 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12312" + term_id: C12312 + term_version: 20.05a + +istiratumab: + common: + description: >- + A bispecific monoclonal antibody directed against the human epidermal growth + factor receptor ErbB3 (Her3) and the human insulin-like growth factor-1 receptor + (IGF-1R), with potential antineoplastic activity. The anti-IGF-1R targeting + arm of Istiratumab binds to IGF-1R on tumor cells thereby preventing the binding + of the natural ligands IGF-1, 2 and heregulin (HRG) to IGF-1R; the anti-ErbB3 + therapeutic arm prevents the binding of neuregulin (NRG) to ErbB3. This prevents + the activation of the PI3K/AKT signal transduction pathway and may result in + both the induction of apoptosis and a decrease in cellular proliferation in + IGF-1R and ErbB3-overexpressing tumor cells. IGF-1R, a receptor tyrosine kinase + of the insulin receptor superfamily, and ErB3, a member of the epidermal growth + factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed + in solid tumors. + termDef: + term: >- + Istiratumab + source: NCIt + cde_id: C103863 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C103863" + term_id: C103863 + term_version: 20.10d + +isx: + common: + description: >- + This gene is involved in gene expression regulation in the intestine. + termDef: + term: >- + ISX Gene + source: NCIt + cde_id: C116411 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116411" + term_id: C116411 + term_version: 20.10d + +italy: + common: + description: >- + A country in southern Europe, occupying a peninsula extending into the central + Mediterranean Sea, northeast of Tunisia. + termDef: + term: >- + Italy + source: NCIt + cde_id: C16761 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16761" + term_id: C16761 + term_version: 19.12e + +itgav: + common: + description: >- + This gene plays a role in cell communication and angiogenesis. + termDef: + term: >- + ITGAV Gene + source: NCIt + cde_id: C53661 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53661" + term_id: C53661 + term_version: 20.10d + +itk: + common: + description: >- + This gene is involved in the differentiation and proliferation of T cells. + termDef: + term: >- + ITK Gene + source: NCIt + cde_id: C24526 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24526" + term_id: C24526 + term_version: 20.10d + +ivaltinostat: + common: + description: >- + A histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. + Ivaltinosta tinhibits the catalytic activity of HDAC, resulting in an accumulation + of highly acetylated chromatin histones, followed by the induction of chromatin + remodeling and an altered pattern of gene expression. In particular, this agent + enhances the histone acetylation of the tumor suppressor gene p53. This results + in an accumulation of p53, p53-dependent transactivation and apoptosis in tumor + cells. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin + histone proteins. + termDef: + term: >- + Ivaltinostat + source: NCIt + cde_id: C94225 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94225" + term_id: C94225 + term_version: 20.10d + +ivuxolimab: + common: + description: >- + An agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134; + TNFRSF4), with potential immunostimulatory activity. Upon administration, ivuxolimab + selectively binds to and activates OX40; which induces proliferation of memory + and effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), + this may promote a T-cell-mediated immune response against TAA-expressing tumor + cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor + receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential + role in T-cell activation. + termDef: + term: >- + Ivuxolimab + source: NCIt + cde_id: C121927 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121927" + term_id: C121927 + term_version: 20.10d + +jadassohn_blue_nevus: + common: + description: >- + An intradermal nevus characterized by the presence of benign pigmented dendritic + spindle-shaped melanocytes. It most frequently occurs in the skin of the distal + upper extremities, followed by the lower extremities, scalp, face, and buttocks. + It usually presents as a single blue or blue-black papular lesion less than + 1cm in diameter. Simple excision is usually curative. + termDef: + term: >- + Blue Nevus + source: NCIt + cde_id: C3803 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3803" + term_id: C3803 + term_version: 20.05a + +jak_inhibitor: + common: + description: >- + Any agent that targets, binds to and inhibits the activity of one or more of + the Janus kinase family of enzymes. + termDef: + term: >- + JAK Inhibitor + source: NCIt + cde_id: C172200 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172200" + term_id: C172200 + term_version: 20.10d + +jak1: + common: + description: >- + This gene plays a role in signal transduction. + termDef: + term: >- + JAK1 Gene + source: NCIt + cde_id: C24528 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24528" + term_id: C24528 + term_version: 20.10d + +jak2: + common: + description: >- + This gene is involved in erythropoiesis and signal transduction. + termDef: + term: >- + JAK2 Gene + source: NCIt + cde_id: C24529 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24529" + term_id: C24529 + term_version: 20.10d + +jak3: + common: + description: >- + This gene plays a role in signal transduction. + termDef: + term: >- + JAK3 Gene + source: NCIt + cde_id: C24530 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24530" + term_id: C24530 + term_version: 20.10d + +jamaica: + common: + description: >- + An island in the Caribbean Sea, south of Cuba, between the Cayman Islands and + Haiti. + termDef: + term: >- + Jamaica + source: NCIt + cde_id: C16763 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16763" + term_id: C16763 + term_version: 19.12e + +japan: + common: + description: >- + A country in eastern Asia, occupying an island chain between the North Pacific + Ocean and the Sea of Japan, east of the Korean Peninsula. + termDef: + term: >- + Japan + source: NCIt + cde_id: C16764 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16764" + term_id: C16764 + term_version: 19.12e + +jazf1: + common: + description: >- + This gene may be involved in transcriptional regulation. + termDef: + term: >- + JAZF1 Gene + source: NCIt + cde_id: C73542 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73542" + term_id: C73542 + term_version: 20.10d + +jejunum: + common: + description: >- + The portion of the small intestine that extends from the duodenum to the ileum. + termDef: + term: >- + Jejunum + source: NCIt + cde_id: C12388 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12388" + term_id: C12388 + term_version: 20.05a + +jersey: + common: + description: >- + A British Crown dependency in the English Channel southeast of Guernsey. + termDef: + term: >- + Jersey + source: NCIt + cde_id: C64374 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64374" + term_id: C64374 + term_version: 19.12e + +jordan: + common: + description: >- + A country in the Middle East, northwest of Saudi Arabia. + termDef: + term: >- + Jordan + source: NCIt + cde_id: C16765 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16765" + term_id: C16765 + term_version: 19.12e + +jugular_paraganglioma: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma arising from + paraganglia in the base of the skull and middle ear. + termDef: + term: >- + Jugulotympanic Paraganglioma + source: NCIt + cde_id: C3061 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3061" + term_id: C3061 + term_version: 20.05a + +jugulotympanic_paraganglioma: + common: + description: >- + A benign or malignant extra-adrenal parasympathetic paraganglioma arising from + paraganglia in the base of the skull and middle ear. + termDef: + term: >- + Jugulotympanic Paraganglioma + source: NCIt + cde_id: C3061 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3061" + term_id: C3061 + term_version: 20.05a + +jun: + common: + description: >- + This gene plays a critical role in transcriptional regulation and cellular growth. + termDef: + term: >- + JUN Gene + source: NCIt + cde_id: C19531 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19531" + term_id: C19531 + term_version: 20.10d + +junction_nevus: + common: + description: >- + A nevus characterized by the presence of an intraepidermal proliferation of + nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. + It presents as a small, slightly raised, pigmented skin lesion. + termDef: + term: >- + Junctional Nevus + source: NCIt + cde_id: C4231 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4231" + term_id: C4231 + term_version: 20.05a + +junctional_nevus_nos: + common: + description: >- + A nevus characterized by the presence of an intraepidermal proliferation of + nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. + It presents as a small, slightly raised, pigmented skin lesion. + termDef: + term: >- + Junctional Nevus + source: NCIt + cde_id: C4231 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4231" + term_id: C4231 + term_version: 20.05a + +juvenile_angiofibroma: + common: + description: >- + A morphologic variant of fibroma characterized by the presence of numerous dilated + vascular channels. + termDef: + term: >- + Angiofibroma + source: NCIt + cde_id: C3799 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3799" + term_id: C3799 + term_version: 20.05a + +juvenile_astrocytoma: + common: + description: >- + An astrocytic tumor appearing before the age of twenty one without designation + of benign or malignant nor designated location. + termDef: + term: >- + Childhood Astrocytic Tumor + source: NCIt + cde_id: C9022 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9022" + term_id: C9022 + term_version: 20.05a + +juvenile_carcinoma_of_breast: + common: + description: >- + A rare, low grade invasive adenocarcinoma of the breast characterized by the + presence of cells that secrete milk-like material. Morphologically, it usually + appears as a circumscribed lesion, composed of cystic spaces, tubular structures, + and solid areas. + termDef: + term: >- + Secretory Breast Carcinoma + source: NCIt + cde_id: C4189 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4189" + term_id: C4189 + term_version: 20.05a + +juvenile_chronic_myelomonocytic_leukemia: + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm of childhood that is characterized + by proliferation principally of the granulocytic and monocytic lineages. Myelomonocytic + proliferation is seen in the bone marrow and the blood. The leukemic cells + may infiltrate any tissue, however liver, spleen, lymph nodes, skin, and respiratory + tract are the most common sites of involvement. (WHO, 2001) + termDef: + term: >- + Juvenile Myelomonocytic Leukemia + source: NCIt + cde_id: C9233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9233" + term_id: C9233 + term_version: 20.05a + +juvenile_fibroadenoma: + common: + description: >- + A breast fibroadenoma characterized by epithelial hyperplasia and an increased + stromal cellularity. + termDef: + term: >- + Breast Juvenile Fibroadenoma + source: NCIt + cde_id: C4276 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4276" + term_id: C4276 + term_version: 20.05a + +juvenile_hemangioma: + common: + description: >- + A capillary hemangioma that may regress spontaneously. It occurs in infants + and children. + termDef: + term: >- + Infantile Hemangioma + source: NCIt + cde_id: C6645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6645" + term_id: C6645 + term_version: 20.05a + +juvenile_histiocytoma: + common: + description: >- + A rare, well-circumscribed, pseudo-encapsulated benign fibrous histiocytoma + that arises entirely within the subcutaneous tissue or deep soft tissue. It + usually affects the extremities or the head and neck region. It recurs locally + in a minority of cases. + termDef: + term: >- + Deep Benign Fibrous Histiocytoma + source: NCIt + cde_id: C6492 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6492" + term_id: C6492 + term_version: 20.05a + +juvenile_melanoma: + common: + description: >- + A benign, acquired or congenital, usually single skin lesion. It can occur on + any area of the body, but most commonly occurs on the face of children and the + thighs of young females. It is characterized by a proliferation of large spindle, + oval, or large epithelioid melanocytes in the dermal-epidermal junction. The + melanocytic proliferation subsequently extends into the dermis. + termDef: + term: >- + Spitz Nevus + source: NCIt + cde_id: C27007 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27007" + term_id: C27007 + term_version: 20.05a + +juvenile_myelomonocytic_leukemia: + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm of childhood that is characterized + by proliferation principally of the granulocytic and monocytic lineages. Myelomonocytic + proliferation is seen in the bone marrow and the blood. The leukemic cells + may infiltrate any tissue, however liver, spleen, lymph nodes, skin, and respiratory + tract are the most common sites of involvement. (WHO, 2001) + termDef: + term: >- + Juvenile Myelomonocytic Leukemia + source: NCIt + cde_id: C9233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9233" + term_id: C9233 + term_version: 20.05a + +juvenile_nevus: + common: + description: >- + A benign, acquired or congenital, usually single skin lesion. It can occur on + any area of the body, but most commonly occurs on the face of children and the + thighs of young females. It is characterized by a proliferation of large spindle, + oval, or large epithelioid melanocytes in the dermal-epidermal junction. The + melanocytic proliferation subsequently extends into the dermis. + termDef: + term: >- + Spitz Nevus + source: NCIt + cde_id: C27007 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27007" + term_id: C27007 + term_version: 20.05a + +juxtacortical_chondroma: + common: + description: >- + A benign neoplasm of bone surface composed of hyaline cartilage. It arises + beneath the periosteum and is characterized by the presence of chondrocytes, + a lobulated growth pattern, and calcification. + termDef: + term: >- + Periosteal Chondroma + source: NCIt + cde_id: C4302 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4302" + term_id: C4302 + term_version: 20.05a + +juxtacortical_chondrosarcoma: + common: + description: >- + A chondrosarcoma arising from the surface of bone. It is characterized by a + lobulated growth pattern, high mitotic activity, myxoid stroma formation, and + necrotic changes. It occurs in adults. Clinical presentation includes pain, + and sometimes swelling. + termDef: + term: >- + Periosteal Chondrosarcoma + source: NCIt + cde_id: C7357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7357" + term_id: C7357 + term_version: 20.05a + +juxtacortical_osteosarcoma: + common: + description: >- + A low grade malignant bone-forming mesenchymal neoplasm arising from the surface + of the bone. It usually affects the distal posterior femur, the proximal tibia, + and proximal humerus. Painless swelling is the usual clinical sign. Most patients + are young adults and the prognosis is usually excellent. + termDef: + term: >- + Parosteal Osteosarcoma + source: NCIt + cde_id: C8969 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8969" + term_id: C8969 + term_version: 20.05a + +juxtaglomerular_tumor: + common: + description: >- + A benign, well circumscribed neoplasm arising from the cortex of the kidney. + It secrets renin and the patients usually present with severe hypertension and + marked hypokalemia. Morphologically, it is characterized by the presence of + sheets of polygonal or spindle-shaped neoplastic cells forming a hemangiopericytic + pattern. + termDef: + term: >- + Juxtaglomerular Cell Tumor + source: NCIt + cde_id: C4162 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4162" + term_id: C4162 + term_version: 20.05a + +kanitinib: + common: + description: >- + A tyrosine kinase inhibitor targeting the oncoprotein c-Met (hepatocyte growth + factor receptor; HGFR; MET) and vascular endothelial growth factor receptor + 2 (VEGFR2), with potential anti-angiogenic and antineoplastic activities. Upon + oral administration, kanitinib targets and binds to c-Met and VEGFR2, thereby + disrupting c-Met- and VEGFR2-dependent signal transduction pathways. This may + induce cell death in tumor cells overexpressing c-Met and/or VEGFR2 protein. + c-Met and VEGFR2 are both overexpressed in many tumor cell types and play key + roles in tumor cell proliferation, survival, invasion, metastasis, and tumor + angiogenesis. + termDef: + term: >- + Kanitinib + source: NCIt + cde_id: C168608 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168608" + term_id: C168608 + term_version: 20.10d + +kaposi_sarcoma: + common: + description: >- + A malignant neoplasm characterized by a vascular proliferation which usually + contains blunt endothelial cells. Erythrocyte extravasation and hemosiderin + deposition are frequently present. The most frequent site of involvement is + the skin; however it may also occur internally. It generally develops in people + with compromised immune systems including those with acquired immune deficiency + syndrome (AIDS). + termDef: + term: >- + Kaposi Sarcoma + source: NCIt + cde_id: C9087 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9087" + term_id: C9087 + term_version: 19.12e + +kaposiform_hemangioendothelioma: + common: + description: >- + An intermediate, locally aggressive blood vessel neoplasm characterized by the + presence of spindle endothelial cells, and formation of capillary-sized and + slit-like vascular channels. It is often associated with hemorrhage and hemosiderin + deposition. + termDef: + term: >- + Kaposiform Hemangioendothelioma + source: NCIt + cde_id: C27510 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27510" + term_id: C27510 + term_version: 20.05a + +karyotype: + common: + description: >- + The preparation, analysis, and interpretation of a karyotype, the representation + of the chromosome set of a cell. + termDef: + term: >- + Karyotyping + source: NCIt + cde_id: C16768 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16768" + term_id: C16768 + term_version: 20.10d + +kat6a: + common: + description: >- + This gene is involved in both histone acetylation and transcriptional regulation. + termDef: + term: >- + KAT6A Gene + source: NCIt + cde_id: C71429 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71429" + term_id: C71429 + term_version: 20.10d + +kat6b: + common: + description: >- + This gene plays a role in both transcription and histone acetylation. + termDef: + term: >- + KAT6B Gene + source: NCIt + cde_id: C71431 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71431" + term_id: C71431 + term_version: 20.10d + +kat7: + common: + description: >- + This gene is involved in epigenetic control of gene expression. + termDef: + term: >- + KAT7 Gene + source: NCIt + cde_id: C73660 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73660" + term_id: C73660 + term_version: 20.10d + +kazakhstan: + common: + description: >- + A country in central Asia, northwest of China and south of Russia. + termDef: + term: >- + Kazakhstan + source: NCIt + cde_id: C20107 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20107" + term_id: C20107 + term_version: 19.12e + +kcnj5: + common: + description: >- + This gene is involved in ion transport. + termDef: + term: >- + KCNJ5 Gene + source: NCIt + cde_id: C95838 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95838" + term_id: C95838 + term_version: 20.10d + +kdm5a: + common: + description: >- + This gene plays a role in transcriptional modulation. + termDef: + term: >- + KDM5A Gene + source: NCIt + cde_id: C97595 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97595" + term_id: C97595 + term_version: 20.10d + +kdm5c: + common: + description: >- + This gene is involved in histone modification. + termDef: + term: >- + KDM5C Gene + source: NCIt + cde_id: C97598 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97598" + term_id: C97598 + term_version: 20.10d + +kdm6a: + common: + description: >- + This gene is involved in the modulation of histone methylation. + termDef: + term: >- + KDM6A Gene + source: NCIt + cde_id: C96334 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96334" + term_id: C96334 + term_version: 20.10d + +kdr: + common: + description: >- + This gene plays a role in angiogenesis and vascular regulation. + termDef: + term: >- + KDR Gene + source: NCIt + cde_id: C24532 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24532" + term_id: C24532 + term_version: 20.10d + +kdsr: + common: + description: >- + This gene plays a role in glycosphingolipid metabolism. + termDef: + term: >- + KDSR Gene + source: NCIt + cde_id: C24410 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24410" + term_id: C24410 + term_version: 20.10d + +keap1: + common: + description: >- + This gene is involved in ubiquitin-mediated protein degradation. + termDef: + term: >- + KEAP1 Gene + source: NCIt + cde_id: C112105 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112105" + term_id: C112105 + term_version: 20.10d + +kenya: + common: + description: >- + A country in eastern Africa, bordering the Indian Ocean, between Somalia and + Tanzania. + termDef: + term: >- + Kenya + source: NCIt + cde_id: C16769 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16769" + term_id: C16769 + term_version: 19.12e + +keratinizing: + common: + description: >- + Epithelial dysplasia in which the dysplastic changes, although limited to the + lower basal zone, are so severe that there is a high probability of progression + to invasive carcinoma. + termDef: + term: >- + Keratinizing Dysplasia + source: NCIt + cde_id: C161017 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C161017" + term_id: C161017 + term_version: 20.10d + +keratotoc_papilloma: + common: + description: >- + A benign epithelial neoplasm characterized by a papillary growth pattern and + a proliferation of neoplastic squamous cells without morphologic evidence of + malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, + esophagus, vagina, and vulva. + termDef: + term: >- + Squamous Cell Papilloma + source: NCIt + cde_id: C3712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3712" + term_id: C3712 + term_version: 20.05a + +kiaa1549: + common: + description: >- + This gene may play a role in brain functions. + termDef: + term: >- + KIAA1549 Gene + source: NCIt + cde_id: C98017 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98017" + term_id: C98017 + term_version: 20.10d + +kidney: + common: + description: >- + One of the two bean-shaped organs located on each side of the spine in the retroperitoneum. + The right kidney is located below the liver and the left kidney below the diaphragm. + The kidneys filter and secret the metabolic products and minerals from the blood, + thus maintaining the homeostasis. On the superior pole of each kidney there + is an adrenal gland. Each kidney and adrenal gland is surrounded by fat. + termDef: + term: >- + Kidney + source: NCIt + cde_id: C12415 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12415" + term_id: C12415 + term_version: 20.05a + +kidney_cancer: + common: + description: >- + A carcinoma arising from the epithelium of the renal parenchyma or the renal + pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect + middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass + are common symptoms. + termDef: + term: >- + Kidney Carcinoma + source: NCIt + cde_id: C9384 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9384" + term_id: C9384 + term_version: 19.12e + +kidney_lower_pole: + common: + description: >- + The pole of the kidney located in the lowest region of the kidney. + termDef: + term: >- + Lower Pole of Kidney + source: NCIt + cde_id: C93180 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93180" + term_id: C93180 + term_version: 20.10d + +kidney_nos: + common: + description: >- + One of the two bean-shaped organs located on each side of the spine in the retroperitoneum. + The right kidney is located below the liver and the left kidney below the diaphragm. + The kidneys filter and secret the metabolic products and minerals from the blood, + thus maintaining the homeostasis. On the superior pole of each kidney there + is an adrenal gland. Each kidney and adrenal gland is surrounded by fat. + termDef: + term: >- + Kidney + source: NCIt + cde_id: C12415 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12415" + term_id: C12415 + term_version: 20.05a + +kidney_upper_pole: + common: + description: >- + The pole of the kidney located in the uppermost region of the kidney. + termDef: + term: >- + Upper Pole of Kidney + source: NCIt + cde_id: C93179 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93179" + term_id: C93179 + term_version: 20.10d + +kif5b: + common: + description: >- + This gene is involved in the transport of vesicles along microtubules. + termDef: + term: >- + KIF5B Gene + source: NCIt + cde_id: C101425 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101425" + term_id: C101425 + term_version: 20.10d + +kiribati: + common: + description: >- + A group of 33 coral atolls in the Pacific Ocean, south of Hawaii and northeast + of Jarvis Island. + termDef: + term: >- + Kiribati + source: NCIt + cde_id: C16639 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16639" + term_id: C16639 + term_version: 19.12e + +kit: + common: + description: >- + This gene plays a role in cellular hematopoiesis and differentiations. Mutations + in the gene are associated with several diseases, including acute myelogenous + leukemia, gastrointestinal tumors, and mast cell disease. + termDef: + term: >- + KIT Gene + source: NCIt + cde_id: C18609 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18609" + term_id: C18609 + term_version: 20.10d + +klatskin_tumor: + common: + description: >- + A carcinoma that arises from the junction, or adjacent to the junction, of the + right and left hepatic ducts. + termDef: + term: >- + Hilar Cholangiocarcinoma + source: NCIt + cde_id: C36077 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36077" + term_id: C36077 + term_version: 20.05a + +klf4: + common: + description: >- + This gene plays a role in gene transcription. + termDef: + term: >- + KLF4 Gene + source: NCIt + cde_id: C73449 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73449" + term_id: C73449 + term_version: 20.10d + +klf6: + common: + description: >- + This gene plays a role in transcriptional activation. + termDef: + term: >- + KLF6 Gene + source: NCIt + cde_id: C97448 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97448" + term_id: C97448 + term_version: 20.10d + +klk2: + common: + description: >- + This gene plays a role in proteolysis. + termDef: + term: >- + KLK2 Gene + source: NCIt + cde_id: C26584 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26584" + term_id: C26584 + term_version: 20.10d + +kmt2a: + common: + description: >- + This gene is involved in transcriptional regulation and alterations in the gene + are associated with acute lymphoblastic leukemia. + termDef: + term: >- + KMT2A Gene + source: NCIt + cde_id: C18585 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18585" + term_id: C18585 + term_version: 20.10d + +kmt2c: + common: + description: >- + This gene plays a role in both methylation and transcriptional regulation + termDef: + term: >- + KMT2C Gene + source: NCIt + cde_id: C93091 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93091" + term_id: C93091 + term_version: 20.10d + +kmt2d: + common: + description: >- + This gene plays a role in co-activation of gene expression. + termDef: + term: >- + KMT2D Gene + source: NCIt + cde_id: C24600 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24600" + term_id: C24600 + term_version: 20.10d + +knl1: + common: + description: >- + This gene is involved in both signaling and chromosome alignment in mitosis. + termDef: + term: >- + KNL1 Gene + source: NCIt + cde_id: C97378 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97378" + term_id: C97378 + term_version: 20.10d + +knstrn: + common: + description: >- + This gene plays a role in both mitotic spindle formation and chromosome segregation. + termDef: + term: >- + KNSTRN Gene + source: NCIt + cde_id: C119652 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119652" + term_id: C119652 + term_version: 20.10d + +kosovo: + common: + description: >- + A southeastern European country between Servia and Macedonia. + termDef: + term: >- + Kosovo + source: NCIt + cde_id: C123740 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123740" + term_id: C123740 + term_version: 19.12e + +kras: + common: + description: >- + This gene is involved in signal transduction and apoptosis. + termDef: + term: >- + KRAS Gene + source: NCIt + cde_id: C25785 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25785" + term_id: C25785 + term_version: 20.10d + +kras_g12c_inhibitor_gdc6036: + common: + description: >- + An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, + with potential antineoplastic activity. Upon oral administration, KRAS G12C + inhibitor GDC-6036 selectively targets the KRAS G12C mutant and inhibits KRAS + G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, + serves an important role in cell signaling, division and differentiation. Mutations + of KRAS may induce constitutive signal transduction leading to tumor cell growth, + proliferation, invasion, and metastasis. + termDef: + term: >- + KRAS G12C Inhibitor GDC-6036 + source: NCIt + cde_id: C173995 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173995" + term_id: C173995 + term_version: 20.10d + +kras_g12c_inhibitor_ly3499446: + common: + description: >- + An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, + with potential antineoplastic activity. Upon oral administration, LY3499446 + targets and covalently binds to cytosine 12 within the switch II pocket of GDP-bound + KRAS G12C, thereby inhibiting mutant KRAS-dependent signaling. KRAS, a member + of the RAS family of oncogenes, serves an important role in cell signaling, + division and differentiation. Mutations of KRAS may induce constitutive signal + transduction leading to tumor cell growth, proliferation, invasion, and metastasis. + termDef: + term: >- + KRAS G12C Inhibitor LY3499446 + source: NCIt + cde_id: C166410 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166410" + term_id: C166410 + term_version: 20.10d + +krasg12c_inhibitor_jnj74699157: + common: + description: >- + An orally available, small molecule inhibitor of the oncogenic Kirsten rat sarcoma + virus homolog KRAS glycine-to-cysteine substitution mutation, G12C, with potential + antineoplastic activity. Upon oral administration JNJ-74699157 targets and binds + to cytosine 12 within the switch II pocket of GDP-bound KRAS G12C, thereby inhibiting + mutant KRAS-dependent signaling. KRAS, a member of the RAS family of oncogenes, + serves an important role in cell signaling, division and differentiation. Mutations + of KRAS may induce constitutive signal transduction leading to tumor cell growth, + proliferation, invasion, and metastasis. + termDef: + term: >- + KRASG12C Inhibitor JNJ-74699157 + source: NCIt + cde_id: C167157 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167157" + term_id: C167157 + term_version: 20.10d + +krt20: + common: + description: >- + This gene plays a role in the formation of intestinal epithelia. + termDef: + term: >- + KRT20 Gene + source: NCIt + cde_id: C96457 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96457" + term_id: C96457 + term_version: 20.10d + +krt7: + common: + description: >- + This gene plays a role in DNA replication. + termDef: + term: >- + KRT7 Gene + source: NCIt + cde_id: C96444 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96444" + term_id: C96444 + term_version: 20.10d + +krukenberg_tumor: + common: + description: >- + Metastatic signet-ring cell carcinoma in the ovary. The primary site is the + gastrointestinal tract or breast. + termDef: + term: >- + Krukenberg Tumor + source: NCIt + cde_id: C3153 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3153" + term_id: C3153 + term_version: 20.05a + +ktn1: + common: + description: >- + This gene plays a role in kinesin function. + termDef: + term: >- + KTN1 Gene + source: NCIt + cde_id: C97601 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97601" + term_id: C97601 + term_version: 20.10d + +kuwait: + common: + description: >- + A country in the Middle East, bordering the Persian Gulf, between Iraq and Saudi + Arabia. + termDef: + term: >- + Kuwait + source: NCIt + cde_id: C16775 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16775" + term_id: C16775 + term_version: 19.12e + +kyrgyzstan: + common: + description: >- + A country in central Asia, between southern Kazakhstan and western China. + termDef: + term: >- + Kyrgyzstan + source: NCIt + cde_id: C16771 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16771" + term_id: C16771 + term_version: 19.12e + +l1: + common: + description: >- + Locoregional neuroblastoma without image defined risk factors (IDRFs). + termDef: + term: >- + INRG Stage L1 + source: NCIt + cde_id: C133428 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C133428" + term_id: C133428 + term_version: 20.05a + +l2: + common: + description: >- + Locoregional neuroblastoma with one or more image defined risk factors (IDRFs). + termDef: + term: >- + INRG Stage L2 + source: NCIt + cde_id: C133429 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C133429" + term_id: C133429 + term_version: 20.05a + +labium_majus: + common: + description: >- + One of the two longitudinal folds of skin that form the lateral boundary of + the vulva. It extends from the mons pubis to the perineum. + termDef: + term: >- + Labium Majus + source: NCIt + cde_id: C12306 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12306" + term_id: C12306 + term_version: 20.05a + +labium_minus: + common: + description: >- + One of the two longitudinal folds of skin located between the labia majora. + termDef: + term: >- + Labium Minus + source: NCIt + cde_id: C12307 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12307" + term_id: C12307 + term_version: 20.05a + +lacrimal_gland: + common: + description: >- + Paired, almond-shaped exocrine glands situated superior and posterior to each + orbit of the eye that produce and secrete the watery serous component of tears. + termDef: + term: >- + Lacrimal Gland + source: NCIt + cde_id: C12346 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12346" + term_id: C12346 + term_version: 20.05a + +lactate_dehydrogenase: + common: + description: >- + A quantitative measurement of the amount of lactate dehydrogenase present in + a sample. + termDef: + term: >- + Lactate Dehydrogenase Measurement + source: NCIt + cde_id: C64855 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64855" + term_id: C64855 + term_version: 20.10d + +lactating_adenoma: + common: + description: >- + A tubular type adenoma of the breast in which, during pregnancy and lactation, + the epithelial cells show extensive secretory changes. + termDef: + term: >- + Lactating Adenoma + source: NCIt + cde_id: C9473 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9473" + term_id: C9473 + term_version: 20.05a + +ladiratuzumab_vedotin: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody + directed against the anti-solute carrier family 39 zinc transporter member 6 + (SLC39A6; LIV-1; ZIP6) protein that is conjugated, via a protease-cleavable + linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential + antineoplastic activity. Upon administration and internalization by LIV-1-positive + tumor cells, ladiratuzumab vedotin undergoes enzymatic cleavage to release MMAE + into the cytosol. In turn, MMAE binds to and inhibits tubulin polymerization, + which may result in G2/M phase cell cycle arrest and apoptosis in LIV-1-expressing + tumor cells. LIV-1, a member of the zinc transporter family, is expressed in + several types of solid tumors and plays a key role in tumor cell progression + and metastasis. The linkage system in ladiratuzumab vedotin is highly stable + in plasma, resulting in cytotoxic specificity against LIV-1-positive cells. + termDef: + term: >- + Ladiratuzumab Vedotin + source: NCIt + cde_id: C112001 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112001" + term_id: C112001 + term_version: 20.10d + +lair2_fusion_protein_nc410: + common: + description: >- + A fusion protein of leukocyte-associated immunoglobulin (Ig)-like receptor (LAIR)-2, + a high-affinity collagen receptor, with potential immunomodulatory and antineoplastic + activities. Upon administration, LAIR-2 fusion protein NC410 binds to the ligand + collagen of LAIR-1 (CD305), thereby blocking the binding of LAIR-1 to its ligand + collagen and inhibiting LAIR-1-mediated immune suppression. This may result + in enhanced T-cell and dendritic cell (DC) activities, and cytotoxic T-lymphocyte + (CTL) and anti-tumor immune responses. LAIR-1, a collagen-receptor and an inhibitory + immune receptor belonging to the Ig superfamily, is expressed on many peripheral + blood mononuclear cells (PBMC) including T-cells and DCs. + termDef: + term: >- + LAIR-2 Fusion Protein NC410 + source: NCIt + cde_id: C173559 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173559" + term_id: C173559 + term_version: 20.10d + +landogrozumab: + common: + description: >- + A monoclonal antibody against myostatin (MSTN) with potential anti-cachexia + activity. Upon administration, landogrozumab binds to and neutralizes the MSTN + protein, thereby blocking the MSTN signalling pathway. This may help decrease + muscle protein breakdown and muscle weakness and may attenuate cancer cachexia. + MSTN, a member of the transforming growth factor-beta (TGF-beta) superfamily, + is a negative regulator of muscle growth and development. + termDef: + term: >- + Landogrozumab + source: NCIt + cde_id: C99640 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99640" + term_id: C99640 + term_version: 20.10d + +langerhans_cell_granulomatosis: + common: + description: >- + A neoplastic proliferation of Langerhans cells which contain Birbeck granules + by ultrastructural examination. Three major overlapping syndromes are recognized: + eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. + The clinical course is generally related to the number of organs affected at + presentation. (WHO, 2001) + termDef: + term: >- + Langerhans Cell Histiocytosis + source: NCIt + cde_id: C3107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3107" + term_id: C3107 + term_version: 20.05a + +langerhans_cell_granulomatosis_unifocal: + common: + description: >- + A clinical variant of Langerhans cell histiocytosis characterized by unifocal + involvement of a bone (most often), skin, or lung. Patients are usually older + children or adults usually presenting with a lytic bone lesion. The etiology + is unknown. Morphologically, eosinophilic granuloma is characterized by the + presence of Langerhans cells in a characteristic milieu which includes histiocytes, + eosinophils, neutrophils, and small, mature lymphocytes. + termDef: + term: >- + Eosinophilic Granuloma + source: NCIt + cde_id: C3016 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3016" + term_id: C3016 + term_version: 20.05a + +langerhans_cell_histiocytosis_disseminated: + common: + description: >- + Langerhans cell histiocytosis presenting with disseminated disease. + termDef: + term: >- + Langerhans Cell Histiocytosis, Disseminated + source: NCIt + cde_id: C150703 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150703" + term_id: C150703 + term_version: 20.05a + +langerhans_cell_histiocytosis_generalized: + common: + description: >- + Langerhans cell histiocytosis presenting with disseminated disease. + termDef: + term: >- + Langerhans Cell Histiocytosis, Disseminated + source: NCIt + cde_id: C150703 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150703" + term_id: C150703 + term_version: 20.05a + +langerhans_cell_histiocytosis_monoostotic: + common: + description: >- + Langerhans cell histiocytosis presenting as a solitary lesion. + termDef: + term: >- + Langerhans Cell Histiocytosis, Monostotic + source: NCIt + cde_id: C150701 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150701" + term_id: C150701 + term_version: 20.05a + +langerhans_cell_histiocytosis_multifocal: + common: + description: >- + Langerhans cell histiocytosis presenting with multiple sites of involvement. + termDef: + term: >- + Langerhans Cell Histiocytosis, Polyostotic + source: NCIt + cde_id: C150702 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150702" + term_id: C150702 + term_version: 20.05a + +langerhans_cell_histiocytosis_nos: + common: + description: >- + A neoplastic proliferation of Langerhans cells which contain Birbeck granules + by ultrastructural examination. Three major overlapping syndromes are recognized: + eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. + The clinical course is generally related to the number of organs affected at + presentation. (WHO, 2001) + termDef: + term: >- + Langerhans Cell Histiocytosis + source: NCIt + cde_id: C3107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3107" + term_id: C3107 + term_version: 20.05a + +langerhans_cell_histiocytosis_polyostotic: + common: + description: >- + Langerhans cell histiocytosis presenting with multiple sites of involvement. + termDef: + term: >- + Langerhans Cell Histiocytosis, Polyostotic + source: NCIt + cde_id: C150702 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150702" + term_id: C150702 + term_version: 20.05a + +langerhans_cell_histiocytosis_unifocal: + common: + description: >- + Langerhans cell histiocytosis presenting as a solitary lesion. + termDef: + term: >- + Langerhans Cell Histiocytosis, Monostotic + source: NCIt + cde_id: C150701 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150701" + term_id: C150701 + term_version: 20.05a + +langerhans_cell_sarcoma: + common: + description: >- + A neoplastic proliferation of Langerhans cells with overtly malignant cytologic + features. It can be considered a higher grade variant of Langerhans cell histiocytosis + (LCH) and it can present de novo or progress from antecedent LCH. (WHO, 2001) + termDef: + term: >- + Langerhans Cell Sarcoma + source: NCIt + cde_id: C6921 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6921" + term_id: C6921 + term_version: 20.05a + +laos: + common: + description: >- + A country in southeastern Asia, north and east of Thailand, west of Vietnam. + termDef: + term: >- + Laos + source: NCIt + cde_id: C16780 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16780" + term_id: C16780 + term_version: 19.12e + +laparoscopy: + common: + description: >- + A surgical procedure during which a laparoscope is inserted into the abdomen + to view the abdominopelvic contents for diagnostic and/or therapeutic purposes. + termDef: + term: >- + Laparoscopy + source: NCIt + cde_id: C16969 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16969" + term_id: C16969 + term_version: 20.05a + +laparotomy: + common: + description: >- + Creation of a surgical opening into the abdominal cavity. + termDef: + term: >- + Laparotomy + source: NCIt + cde_id: C15266 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15266" + term_id: C15266 + term_version: 20.05a + +laprituximab_emtansine: + common: + description: >- + A targeted antibody payload (TAP)-based immunoconjugate consisting of a human + monoclonal antibody directed against the epidermal growth factor receptor (EGFR) + conjugated, via a nonreducible thioether linker (succinimidyl trans-4-(maleimidylmethyl)cyclohexane-1-carboxylate + or SMCC), to the cytotoxic agent maytansinoid mertansine (DM1), with potential + antineoplastic activity. Upon intravenous administration, the monoclonal antibody + moiety of laprituximab emtansine binds to and inhibits EGFR on tumor cell surfaces. + Inhibition of EGFR prevents EGFR-mediated signaling and may inhibit tumor cell + proliferation. After internalization, the mertansine moiety binds to tubulin + and interferes with microtubule assembly/disassembly dynamics. This inhibits + both cell division and the proliferation of cancer cells that express EGFR. + EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell + proliferation and survival. Linkage of the antibody and drug, through a nonreducible + linker, appears to contribute to the improved efficacy and reduced toxicity + of this antibody-drug conjugate (ADC) compared to similar ADCs constructed with + reducible linkers. + termDef: + term: >- + Laprituximab Emtansine + source: NCIt + cde_id: C111906 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111906" + term_id: C111906 + term_version: 20.10d + +large_bcell_lymphoma_arising_in_hhv8associated_multicentric_castleman_disease: + common: + description: >- + An aggressive diffuse large B-cell lymphoma occurring in patients with HHV8-positive + multicentric Castleman disease. It is characterized by the presence of human + herpesvirus 8-infected large B-lymphocytes that resemble plasmablasts. It is + usually seen in patients with HIV infection. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman + Disease + source: NCIt + cde_id: C27856 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27856" + term_id: C27856 + term_version: 20.05a + +large_cell_carcinoma_nos: + common: + description: >- + A malignant epithelial neoplasm composed of large, atypical cells. + termDef: + term: >- + Large Cell Carcinoma + source: NCIt + cde_id: C3780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3780" + term_id: C3780 + term_version: 20.05a + +large_cell_carcinoma_with_rhabdoid_phenotype: + common: + description: >- + A large cell lung carcinoma characterized by the presence of rhabdoid cells. + termDef: + term: >- + Lung Large Cell Carcinoma with Rhabdoid Phenotype + source: NCIt + cde_id: C6876 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6876" + term_id: C6876 + term_version: 20.05a + +large_cell_ki1_lymphoma: + common: + description: >- + A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, + CD30 positive cells. The majority of cases are positive for the anaplastic large + cell lymphoma (ALK) protein. The most frequently seen genetic alteration is + a t(2;5) translocation. Majority of patients present with advanced disease. + The most important prognostic indicator is ALK positivity, which has been associated + with a favorable prognosis. (WHO, 2001) + termDef: + term: >- + Anaplastic Large Cell Lymphoma + source: NCIt + cde_id: C3720 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3720" + term_id: C3720 + term_version: 20.05a + +large_cell_medulloblastoma: + common: + description: >- + A medulloblastoma composed of large cells with prominent nucleoli and a larger + amount of cytoplasm in contrast with the cells of the classic medulloblastoma. + termDef: + term: >- + Large Cell Medulloblastoma + source: NCIt + cde_id: C6904 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6904" + term_id: C6904 + term_version: 20.05a + +large_cell_neuroendocrine_carcinoma: + common: + description: >- + A usually aggressive carcinoma composed of large malignant cells which display + neuroendocrine characteristics. It is characterized by the presence of high + mitotic activity and necrotic changes. The vast majority of cases are positive + for neuron-specific enolase. Representative examples include lung, breast, cervical, + and thymic neuroendocrine carcinomas. + termDef: + term: >- + Large Cell Neuroendocrine Carcinoma + source: NCIt + cde_id: C6875 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6875" + term_id: C6875 + term_version: 20.05a + +larotinib_mesylate: + common: + description: >- + The mesylate salt form of larotinib, a reversible pan-ErbB inhibitor with potential + antineoplastic activity. Upon administration, larotinib binds to and inhibits + ErbB tyrosine receptor kinases, which may result in the inhibition of cellular + proliferation and angiogenesis in tumors expressing ErbB. The ErbB protein family, + also called the epidermal growth factor receptor (EGFR) family, plays major + roles in tumor cell proliferation and tumor vascularization. + termDef: + term: >- + Larotinib Mesylate + source: NCIt + cde_id: C172062 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172062" + term_id: C172062 + term_version: 20.10d + +larp4b: + common: + description: >- + This gene is involved in RNA metabolism and translation. + termDef: + term: >- + LARP4B Gene + source: NCIt + cde_id: C143064 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143064" + term_id: C143064 + term_version: 20.10d + +laryngeal_cancer: + common: + description: >- + Carcinoma that arises from the laryngeal epithelium. More than 90% of laryngeal + carcinomas are squamous cell carcinomas. The remainder are adenoid cystic carcinomas, + mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation. + termDef: + term: >- + Laryngeal Carcinoma + source: NCIt + cde_id: C4855 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4855" + term_id: C4855 + term_version: 19.12e + +laryngeal_cartilage: + common: + description: >- + The nine cartilages that comprise the skeleton of the larynx, including the + single thyroid, epiglottic, and cricoid cartilages, and the paired arytenoid, + corniculate, and cuneiform cartilages. + termDef: + term: >- + Laryngeal Cartilage + source: NCIt + cde_id: C12281 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12281" + term_id: C12281 + term_version: 20.05a + +larynx_nos: + common: + description: >- + The cartilaginous structure of the respiratory tract between the pharynx and + the trachea. It contains elastic vocal cords required for sound production. + termDef: + term: >- + Larynx + source: NCIt + cde_id: C12420 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12420" + term_id: C12420 + term_version: 20.05a + +lasp1: + common: + description: >- + This gene is involved in actin-dependent ion transport. + termDef: + term: >- + LASP1 Gene + source: NCIt + cde_id: C97604 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97604" + term_id: C97604 + term_version: 20.10d + +lateral_wall_of_bladder: + common: + description: >- + The aspect of the bladder wall that is located on the side. + termDef: + term: >- + Lateral Wall of the Bladder + source: NCIt + cde_id: C12333 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12333" + term_id: C12333 + term_version: 20.05a + +lateral_wall_of_nasopharynx: + common: + description: >- + The aspect of the nasopharyngeal wall that is located on the side. It contains + the pharyngeal opening of the auditory tube. + termDef: + term: >- + Lateral Wall of the Nasopharynx + source: NCIt + cde_id: C12244 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12244" + term_id: C12244 + term_version: 20.05a + +lateral_wall_of_oropharynx: + common: + description: >- + The aspect of the oropharyngeal wall that is located on the side. + termDef: + term: >- + Lateral Wall of the Oropharynx + source: NCIt + cde_id: C12239 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12239" + term_id: C12239 + term_version: 20.05a + +latvia: + common: + description: >- + A country in eastern Europe, bordering the Baltic Sea, between Estonia and Lithuania. + termDef: + term: >- + Latvia + source: NCIt + cde_id: C16783 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16783" + term_id: C16783 + term_version: 19.12e + +lcis_nos: + common: + description: >- + A non-invasive adenocarcinoma of the breast characterized by a proliferation + of monomorphic cells completely filling the lumina. The overall lobular architecture + is preserved. It is frequently multifocal (90% in some series) and bilateral. It + seldom becomes invasive; however there is an increased risk of infiltrating + ductal adenocarcinoma. + termDef: + term: >- + Lobular Breast Carcinoma In Situ + source: NCIt + cde_id: C4018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4018" + term_id: C4018 + term_version: 20.05a + +lck: + common: + description: >- + This gene is involved in signal transduction and the development/function of + T cells. + termDef: + term: >- + LCK Gene + source: NCIt + cde_id: C18541 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18541" + term_id: C18541 + term_version: 20.10d + +lcp1: + common: + description: >- + This gene plays a role in cytoskeletal remodeling. + termDef: + term: >- + LCP1 Gene + source: NCIt + cde_id: C21294 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21294" + term_id: C21294 + term_version: 20.10d + +lebanon: + common: + description: >- + A country in the Middle East, bordering the Mediterranean Sea, between Israel + and Syria. + termDef: + term: >- + Lebanon + source: NCIt + cde_id: C16784 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16784" + term_id: C16784 + term_version: 19.12e + +lef1: + common: + description: >- + This gene plays a role in both signal transduction and transcription. + termDef: + term: >- + LEF1 Gene + source: NCIt + cde_id: C80032 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80032" + term_id: C80032 + term_version: 20.10d + +left: + common: + description: >- + Being or located on or directed toward the side of the body to the west when + facing north. + termDef: + term: >- + Left + source: NCIt + cde_id: C25229 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25229" + term_id: C25229 + term_version: 20.05a + +legal_guardian: + common: + description: >- + An individual who is authorized under applicable State or local law to consent + on behalf of a child or incapable person to general medical care including participation + in clinical research. + termDef: + term: >- + Guardian + source: NCIt + cde_id: C51828 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51828" + term_id: C51828 + term_version: 19.12e + +leiomyoblastoma: + common: + description: >- + A benign or malignant gastrointestinal stromal tumor with epithelioid morphology. + termDef: + term: >- + Epithelioid Cell Type Gastrointestinal Stromal Tumor + source: NCIt + cde_id: C3486 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3486" + term_id: C3486 + term_version: 20.05a + +leiomyofibroma: + common: + description: >- + A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized + by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, + and a whorled pattern. + termDef: + term: >- + Uterine Corpus Leiomyoma + source: NCIt + cde_id: C3434 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3434" + term_id: C3434 + term_version: 20.05a + +leiomyoma_nos: + common: + description: >- + A well-circumscribed benign smooth muscle neoplasm characterized by the presence + of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled + pattern. + termDef: + term: >- + Leiomyoma + source: NCIt + cde_id: C3157 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3157" + term_id: C3157 + term_version: 20.05a + +leiomyomatosis_nos: + common: + description: >- + A condition characterized by the presence of numerous small benign smooth muscle + neoplasms located throughout the body. + termDef: + term: >- + Leiomyomatosis + source: NCIt + cde_id: C3748 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3748" + term_id: C3748 + term_version: 20.05a + +leiomyosarcoma_nos: + common: + description: >- + An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring + in post-menopausal women. It is characterized by a proliferation of neoplastic + spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory + and myxoid leimyosarcomas. + termDef: + term: >- + Leiomyosarcoma + source: NCIt + cde_id: C3158 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3158" + term_id: C3158 + term_version: 20.05a + +lennert_lymphoma: + common: + description: >- + A variant of peripheral T-cell lymphoma, not otherwise specified. It is characterized + by the presence of neoplastic small lymphocytes infiltrating the lymph nodes + in a diffuse and less frequently interfollicular pattern. There is an associated + proliferation of epithelioid histiocytes forming confluent clusters. + termDef: + term: >- + Lymphoepithelioid Variant Peripheral T-Cell Lymphoma + source: NCIt + cde_id: C7205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7205" + term_id: C7205 + term_version: 20.05a + +lentigo_maligna: + common: + description: >- + An atypical proliferation of atypical melanocytes in the dermal-epidermal junction, + without infiltration of the papillary or reticular dermis. The melanocytic proliferation + is associated with actinic damage and epidermal atrophy. It usually occurs + in the sun-exposed skin of elderly people. It is a form of melanoma in situ. + termDef: + term: >- + Lentigo Maligna + source: NCIt + cde_id: C43372 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43372" + term_id: C43372 + term_version: 20.05a + +lentigo_maligna_melanoma: + common: + description: >- + A melanoma of the skin characterized by single cell infiltration of the papillary + dermis by atypical melanocytes, in a background of lentigo maligna changes. + termDef: + term: >- + Lentigo Maligna Melanoma + source: NCIt + cde_id: C9151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9151" + term_id: C9151 + term_version: 20.05a + +lepidic_predominant_adenocarcinoma: + common: + description: >- + A lung adenocarcinoma characterized by the presence of mildly and moderately + differentiated adenocarcinoma cells across the alveolar walls with at least + one focus of invasive carcinoma measuring more than 5 mm in greatest dimension. + termDef: + term: >- + Lepidic Predominant Adenocarcinoma + source: NCIt + cde_id: C123160 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123160" + term_id: C123160 + term_version: 20.05a + +leptomeningeal_sarcoma: + common: + description: >- + A sarcoma arising from the leptomeninges. + termDef: + term: >- + Leptomeningeal Sarcoma + source: NCIt + cde_id: C8312 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8312" + term_id: C8312 + term_version: 20.05a + +lerociclib: + common: + description: >- + An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) + and 6 (CDK6), with potential antineoplastic activity. Upon administration, lerociclib + selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma + protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S phase transition + and leads to cell cycle arrest. This suppresses DNA replication and decreases + tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated + in many tumor cell types and play a key role in the regulation of both cell + cycle progression from the G1-phase into the S-phase and tumor cell proliferation. + termDef: + term: >- + Lerociclib + source: NCIt + cde_id: C138165 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C138165" + term_id: C138165 + term_version: 20.10d + +lesotho: + common: + description: >- + A country in southern Africa, an enclave of South Africa. + termDef: + term: >- + Lesotho + source: NCIt + cde_id: C16787 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16787" + term_id: C16787 + term_version: 19.12e + +lesser_curvature_of_stomach_nos: + common: + description: >- + The right border of the stomach. It is concave in shape and extends from the + cardiac orifice to the pyloric orifice. + termDef: + term: >- + Lesser Curvature of the Stomach + source: NCIt + cde_id: C12261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12261" + term_id: C12261 + term_version: 20.05a + +letetresgene_autoleucel: + common: + description: >- + Human autologous T-lymphocytes transduced with a lentiviral vector encoding + a T-cell receptor (TCR) specific for the cancer-testis antigens (CTAs) NY-ESO-1 + and L antigen family member 1 (LAGE-1; Cancer/Testis Antigen 2; CTAG2; CT2), + with potential antineoplastic activity. Following leukapheresis, isolation of + lymphocytes, expansion ex vivo, transduction, and reintroduction into the patient, + letetresgene autoleucel specifically target and bind to NY-ESO-1/LAGE-1-overexpressing + tumor cells. This may result in a cytotoxic T-lymphocyte (CTL)-mediated elimination + of NY-ESO-1/LAGE-1-positive cancer cells. NY-ESO-1 and LAGE-1, members of the + cancer-testis antigen (CTA) family, are overexpressed on the surface of various + tumor cell types. + termDef: + term: >- + Letetresgene Autoleucel + source: NCIt + cde_id: C121379 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121379" + term_id: C121379 + term_version: 20.10d + +letolizumab: + common: + description: >- + A dimeric fusion protein composed of the C-terminus of the domain antibody (dAb) + BMS2h-572-633 targeting the CD40 ligand (CD40L or CD154) linked to a modified + Fc fragment of immunoglobulin G1 (IgG1), with potential immunomodulatory activity. + Upon intravenous administration, the peptide moiety of letolizumab specifically + targets and binds to CD40L expressed on T-lymphocytes. This prevents the binding + of CD40L to its cognate receptor CD40 expressed on B-lymphocytes, macrophages, + and dendritic cells (DCs). This prevents T-cell mediated proliferation and differentiation + of B-cells, and prevents the production of antibodies. By inhibiting both the + production of anti-glycoprotein (GP) IIb/IIIa antibodies by B-cells and GPIIb/IIIa-dependent + T-cell proliferation, letolizumab may prevent platelet destruction and may increase + platelet counts in idiopathic thrombocytopenic purpura (ITP). The direct binding + of letolizumab to CD40L on platelets further prevents CD40L/CD40-mediated destruction + by macrophages and DCs in ITP. The modified Fc domain prevents the binding of + letolizumab to the Fc receptor FcgammaRIIA on platelets, thereby preventing + FcgammaRIIA-dependent platelet activation and anti-CD40L-induced thromboembolism. + CD40L, a transmembrane protein of the tumor necrosis factor (TNF) superfamily, + is primarily expressed on activated T-cells, but is also expressed on eosinophils, + basophils, natural killer (NK) cells, mast cells, platelets and activated endothelial + cells. + termDef: + term: >- + Letolizumab + source: NCIt + cde_id: C120140 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C120140" + term_id: C120140 + term_version: 20.10d + +letterersiwe_disease: + common: + description: >- + A multifocal, multisystem form of Langerhans-cell histiocytosis. There is involvement + of multiple organ systems including the bones, skin, liver, spleen, and lymph + nodes. Patients are usually infants presenting with fever, hepatosplenomegaly, + lymphadenopathy, bone and skin lesions, and pancytopenia. + termDef: + term: >- + Letterer-Siwe Disease + source: NCIt + cde_id: C3160 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3160" + term_id: C3160 + term_version: 20.05a + +leukemia: + common: + description: >- + A malignant (clonal) hematologic disorder, involving hematopoietic stem cells + and characterized by the presence of primitive or atypical myeloid or lymphoid + cells in the bone marrow and the blood. Leukemias are classified as acute or + chronic based on the degree of cellular differentiation and the predominant + cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic + episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, + chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic + leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; + untreated, the natural course of acute leukemias is normally measured in weeks + or months, while that of chronic leukemias is more often measured in months + or years. + termDef: + term: >- + Leukemia + source: NCIt + cde_id: C3161 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3161" + term_id: C3161 + term_version: 19.12e + +leukemia_nos: + common: + description: >- + A malignant (clonal) hematologic disorder, involving hematopoietic stem cells + and characterized by the presence of primitive or atypical myeloid or lymphoid + cells in the bone marrow and the blood. Leukemias are classified as acute or + chronic based on the degree of cellular differentiation and the predominant + cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic + episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, + chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic + leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; + untreated, the natural course of acute leukemias is normally measured in weeks + or months, while that of chronic leukemias is more often measured in months + or years. + termDef: + term: >- + Leukemia + source: NCIt + cde_id: C3161 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3161" + term_id: C3161 + term_version: 20.05a + +leukemic_reticuloendotheliosis: + common: + description: >- + A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, + and peripheral blood. Most patients present with splenomegaly and pancytopenia. + (WHO, 2001) + termDef: + term: >- + Hairy Cell Leukemia + source: NCIt + cde_id: C7402 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7402" + term_id: C7402 + term_version: 20.05a + +leukocytes: + common: + description: >- + A test to determine the number of leukocytes in a biospecimen. + termDef: + term: >- + Leukocyte Count + source: NCIt + cde_id: C51948 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51948" + term_id: C51948 + term_version: 20.10d + +leydig_cell_tumor_benign: + common: + description: >- + A Leydig cell tumor which does not recur or metastasize. Morphologically, there + is no evidence of cellular atypia, increased mitotic activity, necrosis, or + vascular invasion. + termDef: + term: >- + Benign Leydig Cell Tumor + source: NCIt + cde_id: C4212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4212" + term_id: C4212 + term_version: 20.05a + +leydig_cell_tumor_malignant: + common: + description: >- + A Leydig cell tumor characterized by large tumor size, the presence of cytologic + atypia, increased mitotic activity, necrosis, and vascular invasion. Approximately + 10% of the testicular Leydig cell tumors show malignant characteristics and + metastasize. Leydig cell tumors of the ovary follow a benign clinical course. + termDef: + term: >- + Malignant Leydig Cell Tumor + source: NCIt + cde_id: C4213 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4213" + term_id: C4213 + term_version: 20.05a + +leydig_cell_tumor_nos: + common: + description: >- + A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It + is predominantly or completely composed of Leydig cells which may contain crystals + of Reinke. In males it usually presents as a painless testicular enlargement + and it may be associated with gynecomastia and decreased libido. The majority + of the cases have a benign clinical course. Approximately 10% of the cases have + a malignant clinical course and metastasize. In females it may be associated + with androgenic manifestations and it follows a benign clinical course. + termDef: + term: >- + Leydig Cell Tumor + source: NCIt + cde_id: C3188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3188" + term_id: C3188 + term_version: 20.05a + +lhfp: + common: + description: >- + This gene may play a role in cell adhesion or cell proliferation. + termDef: + term: >- + LHFPL6 Gene + source: NCIt + cde_id: C97607 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97607" + term_id: C97607 + term_version: 20.10d + +liberia: + common: + description: >- + A country in western Africa, bordering the North Atlantic Ocean, between Cote + d'Ivoire and Sierra Leone. + termDef: + term: >- + Liberia + source: NCIt + cde_id: C16791 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16791" + term_id: C16791 + term_version: 19.12e + +libya: + common: + description: >- + A country in northern Africa, bordering the Mediterranean Sea, between Egypt + and Algeria. + termDef: + term: >- + Libya + source: NCIt + cde_id: C16793 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16793" + term_id: C16793 + term_version: 19.12e + +liechtenstein: + common: + description: >- + A country in central Europe, between Austria and Switzerland. + termDef: + term: >- + Liechtenstein + source: NCIt + cde_id: C16794 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16794" + term_id: C16794 + term_version: 19.12e + +lifelong_nondrinker: + common: + description: >- + An individual who does not drink at the present time and who claims that they + have never been a drinker. + termDef: + term: >- + Lifelong Non-Drinker + source: NCIt + cde_id: C126380 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126380" + term_id: C126380 + term_version: 19.12e + +lifileucel: + common: + description: >- + A preparation of autologous tumor infiltrating lymphocytes (TILs), with potential + antineoplastic activity. TILs are isolated from a patient's tumor tissue, cultured + in vitro with high-dose interleukin-2 (lL-2), further selected based on antigen + specificity and tumor reactivity, and the selected TILs are subsequently expanded. + Upon re-introduction of lifileucel into the patient, the TILs re-infiltrate + the tumor, specifically recognize the tumor-associated antigens (TAAs), and + initiate tumor cell lysis. IL-2 induces the proliferation and expansion of TILs + in vitro. + termDef: + term: >- + Lifileucel + source: NCIt + cde_id: C120552 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C120552" + term_id: C120552 + term_version: 20.10d + +lifirafenib: + common: + description: >- + An inhibitor of the serine/threonine protein kinase B-raf (BRAF) and epidermal + growth factor receptor (EGFR), with potential antineoplastic activity. Lifirafenib + selectively binds to and inhibits the activity of BRAF and certain BRAF mutant + forms, and EGFR. This prevents BRAF- and EGFR-mediated signaling and inhibits + the proliferation of tumor cells that either contain a mutated BRAF gene or + express over-activated EGFR. In addition, BGB-283 inhibits mutant forms of the + Ras proteins K-RAS and N-RAS. BRAF and EGFR are mutated or upregulated in many + tumor cell types. + termDef: + term: >- + Lifirafenib + source: NCIt + cde_id: C124995 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124995" + term_id: C124995 + term_version: 20.10d + +lifr: + common: + description: >- + This gene plays a critical role in cell fate and proliferation in both embryonic + and adult cells. + termDef: + term: >- + LIFR Gene + source: NCIt + cde_id: C24552 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24552" + term_id: C24552 + term_version: 20.10d + +likely_benign: + common: + description: >- + A genetic variant that is not expected to contribute to the development of a + disease, but the scientific evidence may be insufficient to prove this conclusively. + termDef: + term: >- + Variant Likely Benign + source: NCIt + cde_id: C168801 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168801" + term_id: C168801 + term_version: 20.10d + +likely_pathogenic: + common: + description: >- + A genetic variant that is known to have a high likelihood (greater than 90% + certainty) to contribute to the development of a disease. + termDef: + term: >- + Likely Pathogenic Variant + source: NCIt + cde_id: C168800 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168800" + term_id: C168800 + term_version: 20.10d + +lilotomab: + common: + description: >- + A murine immunoglobulin G1 (IgG1) monoclonal antibody directed against the CD37 + antigen with potential antineoplastic activity. Upon administration, lilotomab + both activates the immune system to induce an antibody-dependent cell-mediated + cytotoxicity (ADCC) against CD37-overexpressing tumor cells and induces apoptosis + in these tumor cells. CD37 is a transmembrane glycoprotein expressed at high-levels + on B-cells and to a lesser extent on T-cells and myeloid cells, and is frequently + overexpressed in certain B-cell malignancies. + termDef: + term: >- + Lilotomab + source: NCIt + cde_id: C165685 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165685" + term_id: C165685 + term_version: 20.10d + +lingual_tonsil: + common: + description: >- + The lymphoid follicles on the dorsal surface in the posterior region of the + tongue. + termDef: + term: >- + Lingual Tonsil + source: NCIt + cde_id: C32988 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32988" + term_id: C32988 + term_version: 20.05a + +linitis_plastica: + common: + description: >- + A cancer-related condition in which the gastric wall becomes thickened and rubbery + (leather-bottle stomach). It is most often associated with diffuse gastric adenocarcinomas. + termDef: + term: >- + Linitis Plastica + source: NCIt + cde_id: C3190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3190" + term_id: C3190 + term_version: 20.05a + +linperlisib: + common: + description: >- + An orally available selective inhibitor of the delta form of phosphatidylinositol + 3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic + activity. Upon oral administration linperlisib selectively binds to and inhibits + PI3K-delta and prevents the activation of the PI3K/AKT signaling pathway. This + decreases proliferation of and induces cell death in PI3K-delta over-expressing + tumor cells. PI3K-delta also plays a key role in the B-cell receptor (BCR) signaling + pathway and the proliferation of certain hematologic cancer cells. The targeted + inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic + cells, thereby minimizing serious side effects. + termDef: + term: >- + Linperlisib + source: NCIt + cde_id: C158508 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C158508" + term_id: C158508 + term_version: 20.10d + +lip_nos: + common: + description: >- + Fleshy fold which surrounds the opening of the mouth. + termDef: + term: >- + Lip + source: NCIt + cde_id: C12220 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12220" + term_id: C12220 + term_version: 20.05a + +lipid_cell_tumor_of_ovary: + common: + description: >- + An ovarian tumor in which the vast majority of the cells (more than 90% of the + tumor cells) resemble steroid hormone-secreting cells. It usually presents with + androgenic manifestations. Approximately one-third of the cases follow a malignant + clinical course. + termDef: + term: >- + Ovarian Steroid Cell Tumor + source: NCIt + cde_id: C4215 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4215" + term_id: C4215 + term_version: 20.05a + +lipid_nanoparticle_encapsulating_glutathione_stransferase_p_sirna_nbf006: + common: + description: >- + A biodegradable, lyophilized lipid nanoparticle (LNP) encapsulating small interfering + ribonucleic acid (siRNA) directed against glutathione S-transferase P (GSTP), + with potential antineoplastic activity. Upon administration of LNP encapsulating + GSTP siRNA NBF-006, the LNP formulation delivers the siRNA particles to the + tumor cells where the GSTP siRNA targets and binds to GSTP mRNA. This results + in the inhibition of the translation and expression of GSTP and may inhibit + proliferation of KRAS-overexpressing tumor cells. GSTP, an enzyme overexpressed + in many tumor cell types, is involved in modulating MAP kinase-related cell-signaling + pathways. + termDef: + term: >- + Lipid Nanoparticle Encapsulating Glutathione S-transferase P siRNA NBF-006 + source: NCIt + cde_id: C170753 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170753" + term_id: C170753 + term_version: 20.10d + +lipidrich_carcinoma: + common: + description: >- + A carcinoma characterized by the presence of malignant epithelial cells with + clear cytoplasm which contains neutral lipids. A representative example is the + lipid-rich breast carcinoma. + termDef: + term: >- + Lipid-Rich Carcinoma + source: NCIt + cde_id: C4152 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4152" + term_id: C4152 + term_version: 20.05a + +lipidrich_urothelial_carcinoma: + common: + description: >- + A variant of infiltrating bladder urothelial carcinoma characterized by the + presence of lipid laden tumor cells. + termDef: + term: >- + Infiltrating Bladder Urothelial Carcinoma, Lipid-Rich Variant + source: NCIt + cde_id: C39828 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39828" + term_id: C39828 + term_version: 20.05a + +lipoadenoma: + common: + description: >- + An adenoma in which the neoplastic epithelial cells are admixed with adipose + tissue cells. + termDef: + term: >- + Lipoadenoma + source: NCIt + cde_id: C4159 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4159" + term_id: C4159 + term_version: 20.05a + +lipoblastoma: + common: + description: >- + A lipoma usually occurring in the extremities of young children (usually boys). + It is characterized by lobules of adipose tissue, separated by fibrous septa. The + adipose tissue is composed of mature adipocytes and lipoblasts. The lipoblasts + may be scarce, depending on the age of the patient. + termDef: + term: >- + Lipoblastoma + source: NCIt + cde_id: C27483 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27483" + term_id: C27483 + term_version: 20.05a + +lipoblastomatosis: + common: + description: >- + A benign disorder characterized by the presence of multiple lipoblastomas. + termDef: + term: >- + Lipoblastomatosis + source: NCIt + cde_id: C4255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4255" + term_id: C4255 + term_version: 20.05a + +lipoid_cell_tumor_of_ovary: + common: + description: >- + An ovarian tumor in which the vast majority of the cells (more than 90% of the + tumor cells) resemble steroid hormone-secreting cells. It usually presents with + androgenic manifestations. Approximately one-third of the cases follow a malignant + clinical course. + termDef: + term: >- + Ovarian Steroid Cell Tumor + source: NCIt + cde_id: C4215 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4215" + term_id: C4215 + term_version: 20.05a + +lipoleiomyoma: + common: + description: >- + A benign extrauterine tumor composed of mature adipocytes and smooth muscle + cells. + termDef: + term: >- + Myolipoma + source: NCIt + cde_id: C9502 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9502" + term_id: C9502 + term_version: 20.05a + +lipoma_nos: + common: + description: >- + A benign, usually painless, well-circumscribed lipomatous tumor composed of + adipose tissue. + termDef: + term: >- + Lipoma + source: NCIt + cde_id: C3192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3192" + term_id: C3192 + term_version: 20.05a + +lipomalike_liposarcoma: + common: + description: >- + An intermediate, locally aggressive lipomatous neoplasm. Microscopically, the + adipose tissue contains large and pleomorphic lipoblasts, and is dissected by + fibrous septa containing spindle cells. It requires a wide local excision, + may recur locally, but never metastasizes. + termDef: + term: >- + Atypical Lipomatous Tumor + source: NCIt + cde_id: C6505 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6505" + term_id: C6505 + term_version: 20.05a + +lipomatous_medulloblastoma: + common: + description: >- + A rare, WHO grade II cerebellar neoplasm which shows consistent neuronal, variable + astrocytic and focal lipomatous differentiation. It occurs in adults, has a + low proliferative potential and usually has a favorable prognosis. (Adapted + from WHO) + termDef: + term: >- + Cerebellar Liponeurocytoma + source: NCIt + cde_id: C6905 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6905" + term_id: C6905 + term_version: 20.05a + +liposarcoma_differentiated: + common: + description: >- + A locally aggressive malignant neoplasm composed of mature adipocytes showing + cell size variation and nuclear atypia. It is often associated with the presence + of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. + There are three histologic subtypes, sclerosing, inflammatory, and spindle cell + liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation. + termDef: + term: >- + Well Differentiated Liposarcoma + source: NCIt + cde_id: C4250 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4250" + term_id: C4250 + term_version: 20.05a + +liposarcoma_nos: + common: + description: >- + A usually painless malignant tumor that arises from adipose tissue. Microscopically, + it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to + pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, + dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential + is higher in less differentiated tumors. + termDef: + term: >- + Liposarcoma + source: NCIt + cde_id: C3194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3194" + term_id: C3194 + term_version: 20.05a + +liposarcoma_well_differentiated: + common: + description: >- + A locally aggressive malignant neoplasm composed of mature adipocytes showing + cell size variation and nuclear atypia. It is often associated with the presence + of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. + There are three histologic subtypes, sclerosing, inflammatory, and spindle cell + liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation. + termDef: + term: >- + Well Differentiated Liposarcoma + source: NCIt + cde_id: C4250 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4250" + term_id: C4250 + term_version: 20.05a + +liposomal_bcl2_antisense_oligonucleotide__bp1002: + common: + description: >- + A liposomal-based nanoparticle composed of an uncharged P-ethoxy antisense oligodeoxynucleotide + (ODN) targeting Bcl-2 mRNA and incorporated in liposomes, with potential antineoplastic + activity. Upon administration of liposomal Bcl-2 antisense oligonucleotide BP1002, + this agent targets and hybridizes with Bcl-2 mRNA and inhibits the expression + of Bcl-2 protein. This may induce tumor cell apoptosis of Bcl2-overexpressing + tumor cells and may decrease tumor cell proliferation. Bcl2, a protein involved + in regulating programmed cell death, is overexpressed in a wide variety of tumors. + It promotes cellular survival and inhibits apoptosis. + termDef: + term: >- + Liposomal Bcl-2 Antisense Oligonucleotide BP1002 + source: NCIt + cde_id: C170743 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170743" + term_id: C170743 + term_version: 20.10d + +liposomeencapsulated_taas_mrna_vaccine_w_ova1: + common: + description: >- + A vaccine consisting of messenger RNA (mRNA) encoding three tumor-associated + antigens (TAAs) specific for ovarian cancer that are encapsulated in liposomes, + with potential immunomodulating and antineoplastic activities. Upon administration + of the liposome-encapsulated TAAs mRNA vaccine W_ova1, the liposomes bind to + the plasma membrane of cells and release the mRNA into the cells. The mRNA is + then translated by ribosomes to produce the TAAs. The TAAs are presented to + the immune system which may activate both humoral and cellular immune responses + against the ovarian cancer cells expressing these TAAs. + termDef: + term: >- + Liposome-encapsulated TAAs mRNA Vaccine W_ova1 + source: NCIt + cde_id: C174421 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174421" + term_id: C174421 + term_version: 20.10d + +lithuania: + common: + description: >- + A country in eastern Europe, bordering the Baltic Sea, between Latvia and Russia. + termDef: + term: >- + Lithuania + source: NCIt + cde_id: C16799 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16799" + term_id: C16799 + term_version: 19.12e + +liver: + common: + description: >- + A triangular-shaped organ located under the diaphragm in the right hypochondrium. + It is the largest internal organ of the body, weighting up to 2 kg. Metabolism + and bile secretion are its main functions. It is composed of cells which have + the ability to regenerate. + termDef: + term: >- + Liver + source: NCIt + cde_id: C12392 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12392" + term_id: C12392 + term_version: 20.05a + +liver_cancer: + common: + description: >- + A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The + main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma. + termDef: + term: >- + Liver and Intrahepatic Bile Duct Carcinoma + source: NCIt + cde_id: C7927 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7927" + term_id: C7927 + term_version: 19.12e + +liver_cell_adenoma: + common: + description: >- + A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears + as a soft, round mass which often contains areas of hemorrhage and necrosis. + Morphologically, the neoplastic cells resemble normal hepatocytes and form plates + separated by sinusoids. Most patients have a history of contraceptive or anabolic + steroids use. + termDef: + term: >- + Hepatocellular Adenoma + source: NCIt + cde_id: C3758 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3758" + term_id: C3758 + term_version: 20.05a + +liver_cell_carcinoma: + common: + description: >- + A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is + relatively rare in the United States but very common in all African countries + south of the Sahara and in Southeast Asia. Most cases are seen in patients over + the age of 50 years, but this tumor can also occur in younger individuals and + even in children. Hepatocellular carcinoma is more common in males than females + and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. + Serum elevation of alpha-fetoprotein occurs in a large percentage of patients + with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present + as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, + there is a wide range of differentiation from tumor to tumor (well differentiated + to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize + to regional lymph nodes and lung. The overall median survival of untreated liver + cell carcinoma is about 4 months. The most effective treatment of hepatocellular + carcinoma is complete resection of the tumor. Lately, an increasing number of + tumors have been treated with liver transplantation. + termDef: + term: >- + Hepatocellular Carcinoma + source: NCIt + cde_id: C3099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3099" + term_id: C3099 + term_version: 20.05a + +lmna: + common: + description: >- + This gene is involved in the architecture of nuclear membrane construction. + termDef: + term: >- + LMNA Gene + source: NCIt + cde_id: C61148 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61148" + term_id: C61148 + term_version: 20.10d + +lmo1: + common: + description: >- + This gene is involved in the regulation of transcription. + termDef: + term: >- + LMO1 Gene + source: NCIt + cde_id: C91263 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C91263" + term_id: C91263 + term_version: 20.10d + +lmo2: + common: + description: >- + This gene plays a crucial role in hematopoietic development and is involved + in transcriptional activation. + termDef: + term: >- + LMO2 Gene + source: NCIt + cde_id: C17973 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17973" + term_id: C17973 + term_version: 20.10d + +lmp2specific_t_cell_receptortransduced_autologous_tlymphocytes: + common: + description: >- + A preparation of autologous T-lymphocytes that have been transduced with a lentiviral + vector encoding a T-cell receptor (TCR) specific for human leukocyte antigen + (HLA)-A02:01/24:02/11:01-restricted Epstein-Barr virus (EBV) latent membrane + proteins (LMP) 1 and 2, and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic + activity. Upon administration, the autologous LMP1/LMP2/EBNA1-specific, HLA-A02:01/24:02/11:01-restricted + TCR-expressing T-lymphocytes YT-E001 recognize and bind to HLA-presented EBV + peptides, which may promote cell death and inhibit the growth of tumor cells + expressing LMP1, LMP2 or EBNA1. LMP1, LMP2, and EBNA1 are expressed in various, + EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive + Hodgkin lymphoma. + termDef: + term: >- + LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes + source: NCIt + cde_id: C172395 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172395" + term_id: C172395 + term_version: 20.10d + +lmp7_inhibitor_m3258: + common: + description: >- + An orally bioavailable, potent, selective, reversible inhibitor of the large + multifunctional peptidase 7 (LMP7, Beta5i, PSMB8), a chymotrypsin-like, proteolytic + subunit of the immunoproteasome, with potential antineoplastic activity. Upon + oral administration, LMP7 inhibitor M3258 targets and inhibits the proteolytic + activity of the LMP7 subunit of immunoproteasome, thereby blocking its deubiquitylating + activity. This blocks the ubiquitin proteasome degradation pathway, prevents + the degradation of defective proteins, and leads to an accumulation of poly-ubiquitylated + proteins. This induces the unfolded protein response (UPR) and results in both + the induction of tumor cell apoptosis and the inhibition of tumor cell growth. + Proteasomes are large multi-subunit protease complexes that degrade unneeded + or damaged proteins that have been ubiquitinated, thereby restoring protein + homeostasis. Unlike the constitutive proteasome, which is expressed in most + tissues, immunoproteasome is specifically present in normal and malignant hematopoietic + cells, including multiple myeloma. Immunoproteasome degrades ubiquitinated proteins, + generates peptides for presentation on MHC class I, and plays a key role in + the adaptive immune response and inflammatory diseases. + termDef: + term: >- + LMP7 Inhibitor M3258 + source: NCIt + cde_id: C169060 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C169060" + term_id: C169060 + term_version: 20.10d + +lobular_adenocarcinoma: + common: + description: >- + An adenocarcinoma of the breast arising from the lobules. This is a relatively + uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas + and is often bilateral or multifocal. + termDef: + term: >- + Lobular Breast Carcinoma + source: NCIt + cde_id: C3771 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3771" + term_id: C3771 + term_version: 20.05a + +lobular_and_ductal_carcinoma: + common: + description: >- + A breast carcinoma characterized by the presence of a lobular and a ductal component. + The ductal component comprises less than 50 percent of the tumor. + termDef: + term: >- + Mixed Ductal and Lobular Carcinoma + source: NCIt + cde_id: C5160 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5160" + term_id: C5160 + term_version: 20.05a + +lobular_carcinoma_in_situ_nos: + common: + description: >- + A non-invasive adenocarcinoma of the breast characterized by a proliferation + of monomorphic cells completely filling the lumina. The overall lobular architecture + is preserved. It is frequently multifocal (90% in some series) and bilateral. It + seldom becomes invasive; however there is an increased risk of infiltrating + ductal adenocarcinoma. + termDef: + term: >- + Lobular Breast Carcinoma In Situ + source: NCIt + cde_id: C4018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4018" + term_id: C4018 + term_version: 20.05a + +lobular_carcinoma_noninfiltrating: + common: + description: >- + A non-invasive adenocarcinoma of the breast characterized by a proliferation + of monomorphic cells completely filling the lumina. The overall lobular architecture + is preserved. It is frequently multifocal (90% in some series) and bilateral. It + seldom becomes invasive; however there is an increased risk of infiltrating + ductal adenocarcinoma. + termDef: + term: >- + Lobular Breast Carcinoma In Situ + source: NCIt + cde_id: C4018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4018" + term_id: C4018 + term_version: 20.05a + +lobular_carcinoma_nos: + common: + description: >- + An adenocarcinoma of the breast arising from the lobules. This is a relatively + uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas + and is often bilateral or multifocal. + termDef: + term: >- + Lobular Breast Carcinoma + source: NCIt + cde_id: C3771 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3771" + term_id: C3771 + term_version: 20.05a + +localized_fibrous_tumor: + common: + description: >- + A localized neoplasm of probable fibroblastic derivation. It is characterized + by the presence of round to spindle-shaped cells, hylanized stroma formation, + thin-walled branching blood vessels, and thin bands of collagen. + termDef: + term: >- + Solitary Fibrous Tumor + source: NCIt + cde_id: C7634 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7634" + term_id: C7634 + term_version: 20.05a + +lodapolimab: + common: + description: >- + A monoclonal antibody directed against programmed cell death-1 ligand 1 (PD-L1) + with immune checkpoint inhibitory and potential antineoplastic activities. Upon + administration, lodapolimab binds to PD-L1 and prevents the interaction of PD-L1 + with its receptor programmed cell death protein 1 (PD-1). This inhibits the + activation of PD-1 and its downstream signaling pathways, which may enhance + the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. + PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 + on T-cells suppresses the immune system and results in immune evasion. PD-1, + a transmembrane protein expressed on activated T-cells, is a negative regulator + of the immune system that limits the expansion and survival of CD8+ T-cells. + termDef: + term: >- + Lodapolimab + source: NCIt + cde_id: C128138 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128138" + term_id: C128138 + term_version: 20.10d + +loss: + common: + description: >- + A gradual decline in amount or activity. + termDef: + term: >- + Loss + source: NCIt + cde_id: C25559 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25559" + term_id: C25559 + term_version: 20.10d + +loss_of_expression: + common: + description: >- + An indication that expression of a gene, RNA species or protein is not detected + in a sample. + termDef: + term: >- + Expression Negative + source: NCIt + cde_id: C165233 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165233" + term_id: C165233 + term_version: 20.10d + +low: + common: + description: >- + A minimum level or position or degree; less than normal in degree, intensity + or amount. + termDef: + term: >- + Low + source: NCIt + cde_id: C54722 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54722" + term_id: C54722 + term_version: 20.05a + +low_grade: + common: + description: >- + Used to describe tumor samples that exhibit well to moderately well differentiated + cells. They are generally expected to be slow growing and less aggressive. + termDef: + term: >- + Low Grade + source: NCIt + cde_id: C14161 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C14161" + term_id: C14161 + term_version: 20.05a + pathology_detail: + dysplasia_degree: + description: >- + A subjective characterization of the phenomenon of dysplasia, based on microscopic + examination of the architectural and/or cytological changes in a tissue sample, + that is determined to be low. + termDef: + term: >- + Low Grade Dysplasia + source: NCIt + cde_id: C156084 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156084" + term_id: C156084 + term_version: 20.10d + +low_grade_adenosquamous_carcinoma: + common: + description: >- + A low grade metaplastic carcinoma of the breast with morphologic features similar + to the adenosquamous carcinoma of the skin. In the majority of cases the prognosis + is excellent. + termDef: + term: >- + Low Grade Adenosquamous Breast Carcinoma + source: NCIt + cde_id: C40362 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40362" + term_id: C40362 + term_version: 20.05a + +low_grade_appendiceal_mucinous_neoplasm: + common: + description: >- + A well differentiated mucinous adenocarcinoma that arises from the appendix. It + is characterized by slow growth and it is associated with the development of + pseudomyxoma peritonei. Unlike the high grade mucinous adenocarcinoma of the + appendix, it usually does not spread beyond the peritoneum and it does not metastasize + to distant anatomic sites. + termDef: + term: >- + Low-Grade Appendix Mucinous Neoplasm + source: NCIt + cde_id: C42598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C42598" + term_id: C42598 + term_version: 20.05a + +low_grade_cribriform_cystadenocarcinoma_lgccc: + common: + description: >- + A rare, low-grade adenocarcinoma that arises from the salivary glands. It is + characterized by the presence of cystic structures lined by ductal cells which + are arranged in cribriform patterns. Adjacent ducts show intraductal proliferation. + termDef: + term: >- + Intraductal Carcinoma of the Minor Salivary Gland + source: NCIt + cde_id: C62192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62192" + term_id: C62192 + term_version: 20.05a + +low_grade_dysplasia: + common: + description: >- + A subjective characterization of the phenomenon of dysplasia, based on microscopic + examination of the architectural and/or cytological changes in a tissue sample, + that is determined to be low. + termDef: + term: >- + Low Grade Dysplasia + source: NCIt + cde_id: C156084 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156084" + term_id: C156084 + term_version: 20.05a + +low_grade_g1: + common: + description: >- + A low-grade lesion, corresponding to Broder's Grades 1 or 2, with a low risk + for distant spread (< 25%). These tumors are characterized by low mitotic rates, + low nuclear to cytoplasmic ratio, and limited pleomorphism. + termDef: + term: >- + Enneking Low Surgical Grade + source: NCIt + cde_id: C140260 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140260" + term_id: C140260 + term_version: 20.05a + +low_risk: + diagnosis: + international_prognostic_index: + description: >- + A risk group associated with a total score of 0 or 1 on the International + Prognostic Index indicating that an individual has a 5 year survival prognosis + of 73%. + termDef: + term: >- + International Prognostic Index Low Risk Group + source: NCIt + cde_id: C161806 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C161806" + term_id: C161806 + term_version: 20.05a + common: + description: >- + The potential future harm that may arise from some present action or attribute + or condition is small. + termDef: + term: >- + Low Risk + source: NCIt + cde_id: C102403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102403" + term_id: C102403 + term_version: 20.05a + +lower_gum: + common: + description: >- + Lower Gingiva + termDef: + term: >- + Lower Gingiva + source: NCIt + cde_id: C54204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54204" + term_id: C54204 + term_version: 20.05a + +lower_limb_nos: + common: + description: >- + The limb that is composed of the hip, thigh, leg and foot. + termDef: + term: >- + Lower Extremity + source: NCIt + cde_id: C12742 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12742" + term_id: C12742 + term_version: 20.05a + +lower_lobe_lung: + common: + description: >- + The bottom most subdivision of either the right or left lung. + termDef: + term: >- + Lower Lobe of the Lung + source: NCIt + cde_id: C12287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12287" + term_id: C12287 + term_version: 20.05a + +lower_third_of_esophagus: + common: + description: >- + The lower one third of the esophagus in which the muscle layer is composed of + muscle cells predominantly of the smooth type. + termDef: + term: >- + Lower Third of the Esophagus + source: NCIt + cde_id: C12255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12255" + term_id: C12255 + term_version: 20.05a + +lowerinner_quadrant_of_breast: + common: + description: >- + The quarter of the breast which is inferior and medial. + termDef: + term: >- + Lower-Inner Quadrant of the Breast + source: NCIt + cde_id: C12302 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12302" + term_id: C12302 + term_version: 20.05a + +lowerouter_quadrant_of_breast: + common: + description: >- + The quarter of the breast which is inferior and lateral. + termDef: + term: >- + Lower-Outer Quadrant of the Breast + source: NCIt + cde_id: C12304 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12304" + term_id: C12304 + term_version: 20.05a + +lowgrade_central_osteosarcoma: + common: + description: >- + A low grade osteosarcoma arising from the medullary portion of the bone. It + affects the long bones and is characterized by the presence of fibroblastic + stroma and osteoid production. Pain and swelling are the usual sign and symptom. + The prognosis is more favorable than conventional osteosarcoma. + termDef: + term: >- + Low Grade Central Osteosarcoma + source: NCIt + cde_id: C6474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6474" + term_id: C6474 + term_version: 20.05a + +lowgrade_fibromyxoid_sarcoma: + common: + description: >- + A low grade, late-metastasizing variant of fibrosarcoma characterized by alternating + fibrous and myxoid areas and a whorling growth pattern. The neoplastic cells + have a spindle morphology, and lack hyperchromasia or significant nuclear atypia. Approximately + 40% of cases show the focal presence of collagen rosettes. A t(7;16)(q33;p11) + translocation has been identified in the majority of cases, associated with + the presence of FUS-CREB3L2 fusion protein. Rare cases carry the t(11;16)(p11;p11) + translocation which is associated with the presence of the FUS-CREB3L1 fusion + protein. + termDef: + term: >- + Low Grade Fibromyxoid Sarcoma + source: NCIt + cde_id: C45202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45202" + term_id: C45202 + term_version: 20.05a + +lowgrade_intramedullary_osteosarcoma: + common: + description: >- + A low grade osteosarcoma arising from the medullary portion of the bone. It + affects the long bones and is characterized by the presence of fibroblastic + stroma and osteoid production. Pain and swelling are the usual sign and symptom. + The prognosis is more favorable than conventional osteosarcoma. + termDef: + term: >- + Low Grade Central Osteosarcoma + source: NCIt + cde_id: C6474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6474" + term_id: C6474 + term_version: 20.05a + +lowgrade_myofibroblastic_sarcoma: + common: + description: >- + A low grade malignant neoplasm arising from the deep soft tissues. It is characterized + by the presence of spindle-shaped myofibroblasts and collagenous stroma formation + in a storiform growth pattern. Metastasis is very rare. + termDef: + term: >- + Low Grade Myofibroblastic Sarcoma + source: NCIt + cde_id: C49024 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49024" + term_id: C49024 + term_version: 20.05a + +lowintermediate_risk: + common: + description: >- + A risk group associated with a total score of 2 on the International Prognostic + Index indicating that an individual has a 5 year survival prognosis of 69%. + termDef: + term: >- + International Prognostic Index Low-Intermediate Risk Group + source: NCIt + cde_id: C161807 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C161807" + term_id: C161807 + term_version: 20.05a + +lpp: + common: + description: >- + This gene may be involved in cell shape and cell motility. + termDef: + term: >- + LPP Gene + source: NCIt + cde_id: C97610 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97610" + term_id: C97610 + term_version: 20.10d + +lrig3: + common: + description: >- + This gene may be involved in signaling. + termDef: + term: >- + LRIG3 Gene + source: NCIt + cde_id: C101446 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101446" + term_id: C101446 + term_version: 20.10d + +lrp1b: + common: + description: >- + This gene plays a role in low density lipoprotein metabolism. + termDef: + term: >- + LRP1B Gene + source: NCIt + cde_id: C111830 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111830" + term_id: C111830 + term_version: 20.10d + +lrp5_antagonist_bi_905681: + common: + description: >- + An antagonist of the lipoprotein receptor-related protein (LRP) 5, with potential + antineoplastic and immunomodulating activities. Upon administration, LRP5 antagonist + BI 905681 targets and binds to LRP5, thereby blocking the binding of Wnt ligands + to LRP5. This prevents the formation of the serpentine receptor Frizzled (FZD)-Wnt-LRP5 + trimeric complex and prevents the inactivation of the beta-catenin degradation + complex, which leads to beta-catenin degradation. This inhibits the Wnt/beta-catenin + signaling pathway, prevents the beta-catenin-mediated activation of Wnt target + genes, and inhibits the proliferation and survival of Wnt/beta-catenin-driven + tumor cells. In addition, inhibition of Wnt signaling by BI 905681 prevents + Wnt-mediated immune escape, thereby re-activating the immune system, specifically + inducing the activation of dendritic cells (DCs) and activation as well as infiltration + of cytotoxic T-cells into the tumor tissue. The FZD-Wnt-LRP5 trimeric complex + induces phosphorylation of LRP5 intracellular domain leading to inactivation + of the beta-catenin degradation complex, allowing beta-catenin accumulation; + stabilized beta-catenin enters the nucleus and acts as a transcriptional activator + of Wnt target genes. Wnt/beta-catenin signaling plays a key role in tumor cell + proliferation and survival, and resistance to immunotherapy. + termDef: + term: >- + LRP5 Antagonist BI 905681 + source: NCIt + cde_id: C171102 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171102" + term_id: C171102 + term_version: 20.10d + +lsd1_inhibitor_syha1807: + common: + description: >- + An orally available inhibitor of lysine-specific demethylase 1 (LSD1; KDM1A), + with potential antineoplastic activity. Upon oral administration, LSD1 inhibitor + SYHA1807 targets, binds to and inhibits LSD1, a demethylase that suppresses + the expression of target genes by converting the di- and mono-methylated forms + of lysine at position 4 of histone 3 (H3K4) to mono- and unmethylated H3K4, + respectively. LSD1 inhibition enhances H3K4 methylation and increases the expression + of tumor suppressor genes. This may lead to an inhibition of cell growth in + LSD1-overexpressing tumor cells. In addition, LSD1 demethylates mono- or di-methylated + H3K9 which increases gene expression of tumor promoting genes; inhibition of + LSD1 promotes H3K9 methylation and decreases transcription of these genes. LSD1 + is overexpressed in a number of tumor cell types. LSD1 acts on histone H3 as + a transcription co-repressor through demethylation of lysine 4 (H3K4) or as + a transcription co-activator through demethylation of lysine 9 (H3K9). + termDef: + term: >- + LSD1 Inhibitor SYHA1807 + source: NCIt + cde_id: C173722 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173722" + term_id: C173722 + term_version: 20.10d + +lsm14a: + common: + description: >- + This gene plays a role in the storage of mRNA. + termDef: + term: >- + LSM14A Gene + source: NCIt + cde_id: C122884 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122884" + term_id: C122884 + term_version: 20.10d + +lumretuzumab: + common: + description: >- + An immunoconjugate containing a glycoengineered, humanized monoclonal antibody + directed against the human epidermal growth factor receptor HER3 (ErbB3), with + potential antineoplastic activity. Upon administration, lumretuzumab binds + to the extracellular domain of HER3 and inhibits HER3 dimerization; thereby, + preventing EGFR-dependent signaling. In addition, RO5479599 stimulates the immune + system to exert antibody-dependent cellular cytotoxicity (ADCC). This may decrease + proliferation of HER3-overexpressing tumor cells. HER3, a member of the epidermal + growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently + overexpressed in tumors; it has no active kinase domain but is activated through + heterodimerization with other members of the EGFR receptor family, such as HER2. + termDef: + term: >- + Lumretuzumab + source: NCIt + cde_id: C104058 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104058" + term_id: C104058 + term_version: 20.10d + +lung: + common: + description: >- + One of a pair of viscera occupying the pulmonary cavities of the thorax, the + organs of respiration in which aeration of the blood takes place. As a rule, + the right lung is slightly larger than the left and is divided into three lobes + (an upper, a middle, and a lower or basal), while the left has two lobes (an + upper and a lower or basal). Each lung is irregularly conical in shape, presenting + a blunt upper extremity (the apex), a concave base following the curve of the + diaphragm, an outer convex surface (costal surface), an inner or mediastinal + surface (mediastinal surface), a thin and sharp anterior border, and a thick + and rounded posterior border. + termDef: + term: >- + Lung + source: NCIt + cde_id: C12468 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12468" + term_id: C12468 + term_version: 20.05a + +lung_cancer: + common: + description: >- + A carcinoma originating in the lung. Lung carcinomas usually arise from the + epithelium that lines the bronchial tree (bronchogenic carcinomas), and are + classified as small cell or non-small cell carcinomas. Non-small cell lung carcinomas + are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas. + Metastatic carcinomas to the lung are also common, and can be difficult to distinguish + from primary tumors. + termDef: + term: >- + Lung Carcinoma + source: NCIt + cde_id: C4878 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4878" + term_id: C4878 + term_version: 19.12e + +lung_nos: + common: + description: >- + One of a pair of viscera occupying the pulmonary cavities of the thorax, the + organs of respiration in which aeration of the blood takes place. As a rule, + the right lung is slightly larger than the left and is divided into three lobes + (an upper, a middle, and a lower or basal), while the left has two lobes (an + upper and a lower or basal). Each lung is irregularly conical in shape, presenting + a blunt upper extremity (the apex), a concave base following the curve of the + diaphragm, an outer convex surface (costal surface), an inner or mediastinal + surface (mediastinal surface), a thin and sharp anterior border, and a thick + and rounded posterior border. + termDef: + term: >- + Lung + source: NCIt + cde_id: C12468 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12468" + term_id: C12468 + term_version: 20.05a + +lupartumab_amadotin: + common: + description: >- + An antibody-drug conjugate (ADC) composed of an antibody against a structural + homolog of the urokinase-type plasminogen activator receptor (uPAR) and tumor-associated + antigen, C4.4a, and conjugated with a cytotoxic agent, with potential antineoplastic + activity. Upon intravenous administration, lupartumab amadotin targets and binds + to C4.4a-expressing tumor cells. Upon binding and cell entry, the cytotoxic + agent kills the tumor cell. C4.4a, a glycolipid-anchored membrane protein and + a member of the Ly-6 family, is overexpressed by a variety of cancer cell types + whereas it is minimally expressed on healthy cells. + termDef: + term: >- + Lupartumab Amadotin + source: NCIt + cde_id: C116070 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116070" + term_id: C116070 + term_version: 20.10d + +luteinizing_hormone: + common: + description: >- + The determination of the amount of luteinizing hormone present in a sample. + termDef: + term: >- + Luteinizing Hormone Measurement + source: NCIt + cde_id: C74790 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74790" + term_id: C74790 + term_version: 20.10d + +luteinoma: + common: + description: >- + A benign ovarian stromal tumor in which more than 90% of the tumor cells resemble + steroid hormone-secreting cells. Crystals of Reinke are not present. It occurs + in post-menopausal women and it is usually associated with estrogenic effects. + termDef: + term: >- + Ovarian Stromal Luteoma + source: NCIt + cde_id: C3202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3202" + term_id: C3202 + term_version: 20.05a + +luteoma_nos: + common: + description: >- + A benign ovarian stromal tumor in which more than 90% of the tumor cells resemble + steroid hormone-secreting cells. Crystals of Reinke are not present. It occurs + in post-menopausal women and it is usually associated with estrogenic effects. + termDef: + term: >- + Ovarian Stromal Luteoma + source: NCIt + cde_id: C3202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3202" + term_id: C3202 + term_version: 20.05a + +lutetium_lu_177dtpaomburtamab: + common: + description: >- + A radioimmunoconjugate consisting of omburtamab, a murine immunoglobulin G1 + (IgG1) antibody directed against the surface immunomodulatory glycoprotein human + B7-homolog 3 (B7-H3, CD276), conjugated, via the chelating agent diethylenetriaminepentaacetic + acid (DTPA), to the radioisotope lutetium Lu 177, with potential antineoplastic + activity. Upon intracerebroventricular administration of lutetium Lu 177-DTPA-omburtamab, + the omburtamab moiety binds to B7-H3 expressed on certain tumor cells. Upon + binding, lutetium Lu 177-DTPA-omburtamab delivers a cytotoxic dose of beta radiation + to B7-H3-expressing cells. B7-H3, a type I transmembrane protein and a member + of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor + cell types and on various immune cells but is minimally expressed by normal + human tissues. B7-H3 is a negative regulator of T-cell activation; its overexpression + plays a key role in immuno-evasion, tumor cell invasion and metastasis, and + is correlated with poor prognosis. + termDef: + term: >- + Lutetium Lu 177-DTPA-omburtamab + source: NCIt + cde_id: C174423 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174423" + term_id: C174423 + term_version: 20.10d + +luxembourg: + common: + description: >- + A country in western Europe, between France, Belgium, and Germany. + termDef: + term: >- + Luxembourg + source: NCIt + cde_id: C16803 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16803" + term_id: C16803 + term_version: 19.12e + +lyl1: + common: + description: >- + This gene plays a role in transcriptional regulation and is involved in the + pathogenesis of acute lymphoblastic leukemia. + termDef: + term: >- + LYL1 Gene + source: NCIt + cde_id: C24564 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24564" + term_id: C24564 + term_version: 20.10d + +lymph_node_axillary: + common: + description: >- + One of approximately 20-30 lymph nodes in chain formation that traverse the + concavity of the underarm to the clavicle. + termDef: + term: >- + Axillary Lymph Node + source: NCIt + cde_id: C12904 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12904" + term_id: C12904 + term_version: 20.05a + +lymph_node_cancer: + common: + description: >- + A primary or metastatic malignant tumor involving the lymph node. Lymphomas + and metastatic carcinomas are representative examples. + termDef: + term: >- + Malignant Lymph Node Neoplasm + source: NCIt + cde_id: C35812 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35812" + term_id: C35812 + term_version: 19.12e + +lymph_node_inguinal: + common: + description: >- + A superficial or deep lymph node located in the inguinal area. + termDef: + term: >- + Inguinal Lymph Node + source: NCIt + cde_id: C32801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32801" + term_id: C32801 + term_version: 20.05a + +lymph_node_nos: + common: + description: >- + A bean-shaped organ surrounded by a connective tissue capsule. It is part of + the lymphatic system and is found throughout the body. It is composed predominantly + of lymphocytes and its main function is immune protection. + termDef: + term: >- + Lymph Node + source: NCIt + cde_id: C12745 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12745" + term_id: C12745 + term_version: 20.05a + +lymph_nodes_of_axilla_or_arm: + common: + description: >- + One of approximately 20-30 lymph nodes in chain formation that traverse the + concavity of the underarm to the clavicle. + termDef: + term: >- + Axillary Lymph Node + source: NCIt + cde_id: C12904 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12904" + term_id: C12904 + term_version: 20.05a + +lymph_nodes_of_head_face_and_neck: + common: + description: >- + Lymph nodes found within the head and neck region of the body, which drain into + the deep cervical nodes, either directly or indirectly. These include the occipital, + mastoid, parotid, facial, retropharyngeal, submandibular, submental, lingual + and cervical lymph nodes. Any lymph node located in the head or neck. + termDef: + term: >- + Head and Neck Lymph Node + source: NCIt + cde_id: C12358 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12358" + term_id: C12358 + term_version: 20.05a + +lymph_nodes_of_inguinal_region_or_leg: + common: + description: >- + Any lymph node that is located in the inguinal region or in either leg. + termDef: + term: >- + Lymph Node of Inguinal Region or Leg + source: NCIt + cde_id: C12362 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12362" + term_id: C12362 + term_version: 20.05a + +lymphangioendothelial_sarcoma: + common: + description: >- + A malignant neoplasm arising from the endothelial cells of the lymphatic vessels. + termDef: + term: >- + Lymphangiosarcoma + source: NCIt + cde_id: C3205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3205" + term_id: C3205 + term_version: 20.05a + +lymphangioendothelioma_malignant: + common: + description: >- + A malignant neoplasm arising from the endothelial cells of the lymphatic vessels. + termDef: + term: >- + Lymphangiosarcoma + source: NCIt + cde_id: C3205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3205" + term_id: C3205 + term_version: 20.05a + +lymphangioendothelioma_nos: + common: + description: >- + A lymphangioma characterized by the presence of collagen bundle formation. It + has an indolent clinical course and may be associated with skin plaques. + termDef: + term: >- + Acquired Progressive Lymphangioma + source: NCIt + cde_id: C3203 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3203" + term_id: C3203 + term_version: 20.05a + +lymphangioleiomyomatosis: + common: + description: >- + A multifocal neoplasm with perivascular epithelioid cell differentiation affecting + almost exclusively females of child-bearing age. It is characterized by the + presence of smooth muscle and epithelioid cells and by the proliferation of + lymphatic vessels. Sites of involvement include the lungs, mediastinum, and + the retroperitoneum. It usually presents with chylous pleural effusion or ascites. + termDef: + term: >- + Lymphangioleiomyomatosis + source: NCIt + cde_id: C3725 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3725" + term_id: C3725 + term_version: 20.05a + +lymphangioma_nos: + common: + description: >- + A benign lesion composed of dilated lymphatic channels. Painless swelling is + the usual clinical manifestation. + termDef: + term: >- + Lymphangioma + source: NCIt + cde_id: C8965 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8965" + term_id: C8965 + term_version: 20.05a + +lymphangiomyoma: + common: + description: >- + A neoplasm with perivascular epithelioid cell differentiation, often associated + with tuberous sclerosis. It is characterized by the presence of smooth muscle + and epithelioid cells and by the proliferation of lymphatic vessels. Sites of + involvement include the lymph nodes, lung, mediastinum, and retroperitoneum. + termDef: + term: >- + Lymphangioleiomyoma + source: NCIt + cde_id: C3204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3204" + term_id: C3204 + term_version: 20.05a + +lymphangiomyomatosis: + common: + description: >- + A multifocal neoplasm with perivascular epithelioid cell differentiation affecting + almost exclusively females of child-bearing age. It is characterized by the + presence of smooth muscle and epithelioid cells and by the proliferation of + lymphatic vessels. Sites of involvement include the lungs, mediastinum, and + the retroperitoneum. It usually presents with chylous pleural effusion or ascites. + termDef: + term: >- + Lymphangioleiomyomatosis + source: NCIt + cde_id: C3725 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3725" + term_id: C3725 + term_version: 20.05a + +lymphangiosarcoma: + common: + description: >- + A malignant neoplasm arising from the endothelial cells of the lymphatic vessels. + termDef: + term: >- + Lymphangiosarcoma + source: NCIt + cde_id: C3205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3205" + term_id: C3205 + term_version: 20.05a + +lymphatic_leukemic_nos: + common: + description: >- + A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily + the bone marrow and the peripheral blood. This category includes precursor + or acute lymphoblastic leukemias and chronic leukemias. + termDef: + term: >- + Lymphoid Leukemia + source: NCIt + cde_id: C7539 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7539" + term_id: C7539 + term_version: 20.05a + +lymphoblastic_leukemia_nos: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +lymphoblastoma: + common: + description: >- + A lymphoma composed of immature small to medium-sized precursor lymphoid cells + (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma. + termDef: + term: >- + Lymphoblastic Lymphoma + source: NCIt + cde_id: C9360 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9360" + term_id: C9360 + term_version: 20.05a + +lymphoblasts: + common: + description: >- + The determination of the amount of lymphoblasts (immature cells that differentiate + to form lymphocytes) present in a sample. + termDef: + term: >- + Lymphoblast Count + source: NCIt + cde_id: C102278 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102278" + term_id: C102278 + term_version: 20.10d + +lymphocytes: + common: + description: >- + The determination of the number of lymphocytes in a blood sample. + termDef: + term: >- + Lymphocyte Count + source: NCIt + cde_id: C51949 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51949" + term_id: C51949 + term_version: 20.10d + +lymphocytic_leukemia_nos: + common: + description: >- + A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily + the bone marrow and the peripheral blood. This category includes precursor + or acute lymphoblastic leukemias and chronic leukemias. + termDef: + term: >- + Lymphoid Leukemia + source: NCIt + cde_id: C7539 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7539" + term_id: C7539 + term_version: 20.05a + +lymphoepithelial_carcinoma: + common: + description: >- + A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but + also in the tonsils and rarely in other anatomic sites. It is characterized + by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, + syncytial growth pattern, and a lymphoplasmacytic infiltrate. + termDef: + term: >- + Nasopharyngeal-Type Undifferentiated Carcinoma + source: NCIt + cde_id: C4107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4107" + term_id: C4107 + term_version: 20.05a + +lymphoepithelioid_lymphoma: + common: + description: >- + A variant of peripheral T-cell lymphoma, not otherwise specified. It is characterized + by the presence of neoplastic small lymphocytes infiltrating the lymph nodes + in a diffuse and less frequently interfollicular pattern. There is an associated + proliferation of epithelioid histiocytes forming confluent clusters. + termDef: + term: >- + Lymphoepithelioid Variant Peripheral T-Cell Lymphoma + source: NCIt + cde_id: C7205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7205" + term_id: C7205 + term_version: 20.05a + +lymphoepithelioma: + common: + description: >- + A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but + also in the tonsils and rarely in other anatomic sites. It is characterized + by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, + syncytial growth pattern, and a lymphoplasmacytic infiltrate. + termDef: + term: >- + Nasopharyngeal-Type Undifferentiated Carcinoma + source: NCIt + cde_id: C4107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4107" + term_id: C4107 + term_version: 20.05a + +lymphoepitheliomalike_carcinoma: + common: + description: >- + A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but + also in the tonsils and rarely in other anatomic sites. It is characterized + by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, + syncytial growth pattern, and a lymphoplasmacytic infiltrate. + termDef: + term: >- + Nasopharyngeal-Type Undifferentiated Carcinoma + source: NCIt + cde_id: C4107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4107" + term_id: C4107 + term_version: 20.05a + +lymphoid_leukemia_nos: + common: + description: >- + A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily + the bone marrow and the peripheral blood. This category includes precursor + or acute lymphoblastic leukemias and chronic leukemias. + termDef: + term: >- + Lymphoid Leukemia + source: NCIt + cde_id: C7539 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7539" + term_id: C7539 + term_version: 20.05a + +lymphoma: + common: + description: >- + A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which + involves the lymph nodes, bone marrow and/or extranodal sites. This category + includes Non-Hodgkin lymphomas and Hodgkin lymphomas. + termDef: + term: >- + Lymphoma + source: NCIt + cde_id: C3208 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3208" + term_id: C3208 + term_version: 19.12e + +lymphoma_nos: + common: + description: >- + A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which + involves the lymph nodes, bone marrow and/or extranodal sites. This category + includes Non-Hodgkin lymphomas and Hodgkin lymphomas. + termDef: + term: >- + Lymphoma + source: NCIt + cde_id: C3208 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3208" + term_id: C3208 + term_version: 20.05a + +lymphomatoid_granulomatosis: + common: + description: >- + An angiocentric and angiodestructive lymphoproliferative disease involving extranodal + sites, comprised of Epstein-Barr virus (EBV)-positive B-cells admixed with reactive + T-cells. Incidence is higher among adult males; patients with a history of + immunodeficiency are at increased risk. The most common site of involvement + is the lung; other common sites include brain, kidney, liver, and skin. Morphologically, + three grades are recognized: grade I, II, and III. Grade III lymphomatoid granulomatosis + should be approached clinically as a subtype of diffuse large B-cell lymphoma. + termDef: + term: >- + Lymphomatoid Granulomatosis + source: NCIt + cde_id: C7930 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7930" + term_id: C7930 + term_version: 20.05a + +lymphomatoid_papulosis: + common: + description: >- + A chronic, recurrent cutaneous disorder characterized by the presence of spontaneously + regressing papules. The papules are composed of an atypical lymphocytic infiltrate + that contains anaplastic CD30-positive T-cells, which are found in type A and + diffuse large cell type (type C) lymphomatoid papulosis. In a small number + of cases, of type B, the lymphocytic infiltrate is composed of small, cerebriform-like + lymphocytes that are often negative for CD30. The majority of cases follow + a benign clinical course, but some cases are clonal and may progress to lymphoma. Treatment + options include low dose methotrexate and psoralen/UVA (PUVA). + termDef: + term: >- + Lymphomatoid Papulosis + source: NCIt + cde_id: C3721 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3721" + term_id: C3721 + term_version: 20.05a + +lymphoplasmacyterich_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of prominent chronic + inflammatory infiltrates that predominate over the meningioma cells. + termDef: + term: >- + Lymphoplasmacyte-Rich Meningioma + source: NCIt + cde_id: C4720 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4720" + term_id: C4720 + term_version: 20.05a + +lymphoproliferative_disease_nos: + common: + description: >- + A disorder characterized by proliferation of lymphocytes at various stages of + differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as + in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis). + termDef: + term: >- + Lymphoproliferative Disorder + source: NCIt + cde_id: C9308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9308" + term_id: C9308 + term_version: 20.05a + +lymphoproliferative_disorder_nos: + common: + description: >- + A disorder characterized by proliferation of lymphocytes at various stages of + differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as + in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis). + termDef: + term: >- + Lymphoproliferative Disorder + source: NCIt + cde_id: C9308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9308" + term_id: C9308 + term_version: 20.05a + +lymphosarcoma_cell_leukemia: + common: + description: >- + A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily + the bone marrow and the peripheral blood. This category includes precursor + or acute lymphoblastic leukemias and chronic leukemias. + termDef: + term: >- + Lymphoid Leukemia + source: NCIt + cde_id: C7539 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7539" + term_id: C7539 + term_version: 20.05a + +lymphosarcoma_diffuse: + common: + description: >- + An antiquated term that refers to a non-Hodgkin lymphoma composed of small and + medium sized lymphocytes. + termDef: + term: >- + Lymphosarcoma + source: NCIt + cde_id: C26919 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26919" + term_id: C26919 + term_version: 20.05a + +lymphosarcoma_nos: + common: + description: >- + An antiquated term that refers to a non-Hodgkin lymphoma composed of small and + medium sized lymphocytes. + termDef: + term: >- + Lymphosarcoma + source: NCIt + cde_id: C26919 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26919" + term_id: C26919 + term_version: 20.05a + +lztr1: + common: + description: >- + This gene may be involved in Golgi stabilization, embryogenesis or transcriptional + regulation. + termDef: + term: >- + LZTR1 Gene + source: NCIt + cde_id: C128257 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128257" + term_id: C128257 + term_version: 20.10d + +m: + common: + description: >- + Neuroblastoma with distant metastatic disease (except MS). + termDef: + term: >- + INRG Stage M + source: NCIt + cde_id: C133430 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C133430" + term_id: C133430 + term_version: 20.05a + +m_protein: + common: + description: >- + The determination of the amount of monoclonal protein present in a sample. + termDef: + term: >- + Monoclonal Protein Measurement + source: NCIt + cde_id: C92291 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92291" + term_id: C92291 + term_version: 20.10d + +m0: + common: + description: >- + A distant metastasis TNM finding indicating that there is no evidence of distant + metastasis. + termDef: + term: >- + M0 Stage Finding + source: NCIt + cde_id: C48699 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48699" + term_id: C48699 + term_version: 20.05a + diagnosis: + ensat_clinical_m: + description: >- + Adrenal cancer with no involvement of distant organs or tissues. (7th Ed, + 2009) + termDef: + term: >- + cM0 ENSAT Staging Finding v7 + source: NCIt + cde_id: C104028 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104028" + term_id: C104028 + term_version: 23.03d + +m1: + common: + description: >- + A clinical and/or pathologic distant metastasis TNM finding indicating the spread + of cancer to distant anatomic sites. + termDef: + term: >- + M1 Stage Finding + source: NCIt + cde_id: C48700 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48700" + term_id: C48700 + term_version: 20.05a + diagnosis: + ensat_clinical_m: + description: >- + Adrenal cancer with involvement of distant organs or tissues such as liver, + bone or brain. (7th Ed, 2009) + termDef: + term: >- + cM1 ENSAT Staging Finding v7 + source: NCIt + cde_id: C104029 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104029" + term_id: C104029 + term_version: 23.03d + +m1a: + common: + description: >- + A TNM finding indicating the spread of cancer to distant anatomic sites. The + definition of M1a TNM finding depends on the specific type of cancer that it + refers to; for example, for colorectal cancer it refers to metastasis confined + to one organ or site (e.g., liver, lung, ovary, nonregional node); for prostate + cancer it refers to metastasis to non-regional lymph node(s); for bone cancer + it refers to metastasis to the lung. + termDef: + term: >- + M1a Stage Finding + source: NCIt + cde_id: C48701 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48701" + term_id: C48701 + term_version: 20.05a + +m1b: + common: + description: >- + A TNM finding indicating the spread of cancer to distant anatomic sites. The + definition of M1b TNM finding depends on the specific type of cancer that it + refers to; for example, for colorectal cancer it refers to metastases in more + than one organ/site or the peritoneum; for prostate cancer it refers to metastasis + to bone(s); for bone cancer it refers to metastasis to distant sites other than + lung. + termDef: + term: >- + M1b Stage Finding + source: NCIt + cde_id: C48702 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48702" + term_id: C48702 + term_version: 20.05a + +m1c: + common: + description: >- + A TNM finding indicating the spread of cancer to distant anatomic sites. The + definition of M1c TNM finding depends on the specific type of cancer that it + refers to; for example, for prostate cancer it refers to metastasis to anatomic + site(s) other than bone, with or without bone disease; for retinoblastoma it + refers to central nervous system metastasis; for melanoma of the uvea it refers + to distant metastasis, with the largest diameter of the largest metastasis measuring + 8.0 cm or more. + termDef: + term: >- + M1c Stage Finding + source: NCIt + cde_id: C48703 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48703" + term_id: C48703 + term_version: 20.05a + +m6a: + common: + description: >- + Acute erythroid leukemia characterised by the presence of at least 50% erythroid + precursors and at least 20% myeloblasts in the bone marrow. + termDef: + term: >- + Erythroleukemia + source: NCIt + cde_id: C7152 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7152" + term_id: C7152 + term_version: 20.05a + +m6b: + common: + description: >- + Acute erythroid leukemia characterised by the presence of immature erythroid + cells in the bone marrow (at least 80% of the cellular component), without evidence + of a significant myeloblastic cell population present. + termDef: + term: >- + Pure Erythroid Leukemia + source: NCIt + cde_id: C7467 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7467" + term_id: C7467 + term_version: 20.05a + +maackia_amurensis_seed_lectin: + common: + description: >- + A preparation of lectin extracted from the seeds of Maackia amurensis, with + potential antineoplastic activity. Upon administration, Maackia amurensis seed + lectin (MASL) may target and bind to podoplanin (PDPN), thereby blocking the + activation of PDPN by endogenous ligands. This may inhibit tumor cell growth, + migration and metastasis that result from PDPN activation. PDPN, a transmembrane + receptor glycoprotein that is overexpressed in some cancer types, promotes tumor + cell migration, invasion, and metastasis upon activation by various endogenous + ligands. + termDef: + term: >- + Maackia amurensis Seed Lectin + source: NCIt + cde_id: C174518 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174518" + term_id: C174518 + term_version: 20.10d + +macau: + common: + description: >- + A special administrative region of China, bordering the South China Sea, west + of Hong Kong. + termDef: + term: >- + Macau + source: NCIt + cde_id: C16807 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16807" + term_id: C16807 + term_version: 19.12e + +machine_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates through + the direct or nearby use of a machine. + termDef: + term: >- + Machine Smoke Exposure + source: NCIt + cde_id: C164090 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164090" + term_id: C164090 + term_version: 19.12e + +macro: + common: + description: >- + Visible to the naked eye. + termDef: + term: >- + Gross + source: NCIt + cde_id: C43566 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43566" + term_id: C43566 + term_version: 20.05a + +macrocyclebridged_sting_agonist_e7766: + common: + description: >- + An agonist of macrocycle-bridged stimulator of interferon genes (STING) protein, + with potential immunoactivating and antineoplastic activities. Upon intravenous + administration, macrocycle-bridged STING agonist (MBSA) E7766 targets and binds + to STING and activates the STING pathway, which promotes IKK-related kinase + TANK-binding kinase 1 (TBK1) signaling and activates nuclear factor-kappa B + (NF-kB) and interferon regulatory factor 3 (IRF3) in immune cells in the tumor + microenvironment (TME). This leads to the production of pro-inflammatory cytokines, + including interferons (IFNs). Specifically, expression of IFN-beta (IFNb) enhances + the cross-presentation of tumor-associated antigens (TAAs) by CD8alpha-positive + and CD103-positive dendritic cells (DCs) to cytotoxic T-lymphocytes (CTLs). + This results in a CTL-mediated immune response against tumor cells and causes + tumor cell lysis. Compared to conventional STING agonists, MBSA E7766 allows + for conformational rigidity of the unique macrocycle bridge which enhances its + stability and STING affinity, thereby increasing its efficacy. + termDef: + term: >- + Macrocycle-bridged STING Agonist E7766 + source: NCIt + cde_id: C166141 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166141" + term_id: C166141 + term_version: 20.10d + +macrofollicular_adenoma: + common: + description: >- + A thyroid gland adenoma composed of large size follicles. + termDef: + term: >- + Thyroid Gland Macrofollicular Adenoma + source: NCIt + cde_id: C4161 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4161" + term_id: C4161 + term_version: 20.05a + +macroscopic_2cm_or_less: + common: + description: >- + Lesion with Diameter of 2 cm or Less + termDef: + term: >- + Lesion with Diameter of 2cm or Less + source: NCIt + cde_id: C53696 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53696" + term_id: C53696 + term_version: 20.05a + +macroscopic_greater_than_2cm: + common: + description: >- + Lesion with Diameter Greater than 2 cm + termDef: + term: >- + Lesion with Diameter Greater than 2cm + source: NCIt + cde_id: C51138 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51138" + term_id: C51138 + term_version: 20.05a + +madagascar: + common: + description: >- + A country in southern Africa, occupying an island in the Indian Ocean, east + of Mozambique. + termDef: + term: >- + Madagascar + source: NCIt + cde_id: C16808 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16808" + term_id: C16808 + term_version: 19.12e + +maf: + molecular_test: + gene_symbol: + description: >- + This gene plays a role in transcriptional regulation and cellular differentiation. + termDef: + term: >- + MAF Gene + source: NCIt + cde_id: C18417 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18417" + term_id: C18417 + term_version: 20.10d + second_gene_symbol: + description: >- + This gene plays a role in transcriptional regulation and cellular differentiation. + termDef: + term: >- + MAF Gene + source: NCIt + cde_id: C18417 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18417" + term_id: C18417 + term_version: 20.10d + +mafb: + common: + description: >- + This gene plays a role in both hematopoiesis and transcriptional modulation. + termDef: + term: >- + MAFB Gene + source: NCIt + cde_id: C97671 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97671" + term_id: C97671 + term_version: 20.10d + +magea1specific_t_cell_receptortransduced_autologous_tcells: + common: + description: >- + A preparation of autologous CD4- and CD8-positive T-lymphocytes genetically + modified to express a T-cell receptor (TCR) that specifically targets the human + melanoma-associated antigen A1 (MAGE-A1), with potential antineoplastic activity. + Upon isolation, transduction, expansion ex vivo, and reintroduction into the + patient, the MAGE-A1-specific TCR-transduced autologous T-cells bind to tumor + cells expressing MAGE-A1, which may halt the growth of and kill MAGE-A1-expressing + cancer cells. MAGE-A1 is a tumor-associated antigen (TAA) overexpressed by a + variety of cancer cell types. + termDef: + term: >- + MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells + source: NCIt + cde_id: C174139 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174139" + term_id: C174139 + term_version: 20.10d + +magnocellular_nevus: + common: + description: >- + A benign melanocytic proliferation within or adjacent to the optic disk. It + presents as a pigmented, intraocular tumor. + termDef: + term: >- + Melanocytoma of the Eyeball + source: NCIt + cde_id: C4230 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4230" + term_id: C4230 + term_version: 20.05a + +magrolimab: + common: + description: >- + A humanized monoclonal antibody targeting the human cell surface antigen CD47, + with potential immunostimulating and antineoplastic activities. Upon administration, + magrolimab selectively binds to CD47 expressed on tumor cells and blocks the + interaction of CD47 with its ligand signal regulatory protein alpha (SIRPa), + a protein expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling, + allows the activation of macrophages, through the induction of pro-phagocytic + signaling mediated by calreticulin, which is specifically expressed on the surface + of tumor cells, and results in specific tumor cell phagocytosis. In addition, + blocking CD47 signaling activates an anti-tumor T-lymphocyte immune response + and T-mediated cell killing. CD47, a tumor associated antigen expressed on normal, + healthy hematopoietic stem cells (HSC), is overexpressed on the surface of a + variety of cancer cells. Expression of CD47, and interaction with SIRP-alpha, + leads to inhibition of macrophages and protects cancer cells from phagocytosis + thereby allowing cancer cells to proliferate. + termDef: + term: >- + Magrolimab + source: NCIt + cde_id: C117730 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C117730" + term_id: C117730 + term_version: 20.10d + +main_bronchus: + common: + description: >- + The left and right main bronchi considered as a group. + termDef: + term: >- + Main Bronchus + source: NCIt + cde_id: C12284 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12284" + term_id: C12284 + term_version: 20.05a + +major_salivary_gland_nos: + common: + description: >- + An exocrine gland that secretes saliva. Salivary glands are mostly located in + and around the oral cavity. + termDef: + term: >- + Salivary Gland + source: NCIt + cde_id: C12426 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12426" + term_id: C12426 + term_version: 20.05a + +malat1: + common: + description: >- + This gene may play a role in carcinogenesis. + termDef: + term: >- + MALAT1 Gene + source: NCIt + cde_id: C92696 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92696" + term_id: C92696 + term_version: 20.10d + +malawi: + common: + description: >- + A country in southern Africa, east of Zambia and west of Mozambique and Tanzania. + termDef: + term: >- + Malawi + source: NCIt + cde_id: C16813 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16813" + term_id: C16813 + term_version: 19.12e + +malaysia: + common: + description: >- + A country in southeastern Asia bordering Indonesia and the South China Sea, + occupying a peninsula south of Thailand and the northern one-third of the island + of Borneo. + termDef: + term: >- + Malaysia + source: NCIt + cde_id: C16814 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16814" + term_id: C16814 + term_version: 19.12e + +maldives: + common: + description: >- + A country in southern Asia, occupying a group of atolls in the Indian Ocean, + south-southwest of India and north of the British Indian Ocean Territory. + termDef: + term: >- + Maldives + source: NCIt + cde_id: C16815 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16815" + term_id: C16815 + term_version: 19.12e + +male: + common: + description: >- + A person who belongs to the sex that normally produces sperm. The term is used + to indicate biological sex distinctions, cultural gender role distinctions, + or both. + termDef: + term: >- + Male + source: NCIt + cde_id: C20197 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20197" + term_id: C20197 + term_version: 19.12e + +male_cousin: + common: + description: >- + A male child of one's aunt or uncle. + termDef: + term: >- + Male Cousin + source: NCIt + cde_id: C165850 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165850" + term_id: C165850 + term_version: 19.12e + +male_genital_organs_nos: + common: + description: >- + The external male sexual organs. + termDef: + term: >- + Male Genitalia + source: NCIt + cde_id: C61599 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61599" + term_id: C61599 + term_version: 20.05a + +male_sibling_of_adopted_child: + common: + description: >- + A male sibling of an adopted child. The said male is a biological or legal child + of the parents who facilitated the adoption. + termDef: + term: >- + Male Sibling of Adopted Child + source: NCIt + cde_id: C166197 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166197" + term_id: C166197 + term_version: 19.12e + +mali: + common: + description: >- + A country in western Africa, southwest of Algeria and east of Mauritania. + termDef: + term: >- + Mali + source: NCIt + cde_id: C16816 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16816" + term_id: C16816 + term_version: 19.12e + +malignancy: + common: + description: >- + A tumor composed of atypical neoplastic, often pleomorphic cells that invade + other tissues. Malignant neoplasms often metastasize to distant anatomic sites + and may recur after excision. The most common malignant neoplasms are carcinomas, + Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. + termDef: + term: >- + Malignant Neoplasm + source: NCIt + cde_id: C9305 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9305" + term_id: C9305 + term_version: 20.05a + +malignant: + common: + description: >- + Refers to abnormal cell activity manifested by decreased control over growth + and function, causing tumor growth or spread into surrounding tissue and adverse + effects to the host. + termDef: + term: >- + Malignant + source: NCIt + cde_id: C14143 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C14143" + term_id: C14143 + term_version: 20.05a + +malignant_cystic_nephroma: + common: + description: >- + A variant of Wilms tumor of the kidney characterized by the presence of cystic + spaces separated by septa. The septa contain immature epithelial cells, immature + stromal cells, and blastema cells. Surgical resection is usually curative. + termDef: + term: >- + Cystic Partially Differentiated Kidney Nephroblastoma + source: NCIt + cde_id: C6897 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6897" + term_id: C6897 + term_version: 20.05a + +malignant_eccrine_spiradenoma: + common: + description: >- + A very rare, aggressive carcinoma of the sweat glands arising from malignant + transformation of a long standing spiradenoma. It usually grows in the upper + extremities, lower extremities, trunk, and head and neck. It has the tendency + to recur and metastasize most often to the lymph nodes, bones, and lungs. + termDef: + term: >- + Spiradenocarcinoma + source: NCIt + cde_id: C5117 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5117" + term_id: C5117 + term_version: 20.05a + +malignant_fibrous_histiocytoma: + common: + description: >- + An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic + malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma. + termDef: + term: >- + Undifferentiated Pleomorphic Sarcoma + source: NCIt + cde_id: C4247 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4247" + term_id: C4247 + term_version: 20.05a + +malignant_giant_cell_tumor_of_soft_parts: + common: + description: >- + An undifferentiated pleomorphic sarcoma characterized by the presence of osteoclast-like + giant cells and cellular pleomorphism. + termDef: + term: >- + Undifferentiated Pleomorphic Sarcoma with Osteoclast-Like Giant Cells + source: NCIt + cde_id: C8380 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8380" + term_id: C8380 + term_version: 20.05a + +malignant_histiocytosis: + common: + description: >- + An antiquated term referring to cases of systemic non-Hodgkin lymphomas which + are composed of large, atypical neoplastic lymphoid cells and cases of hemophagocytic + syndromes. In the past, cases of anaplastic large cells lymphoma were called + malignant histiocytosis. + termDef: + term: >- + Malignant Histiocytosis + source: NCIt + cde_id: C7202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7202" + term_id: C7202 + term_version: 20.05a + +malignant_hydatidiform_mole: + common: + description: >- + A complete hydatidiform mole or very rarely a partial mole that invades the + myometrium. + termDef: + term: >- + Invasive Hydatidiform Mole + source: NCIt + cde_id: C6985 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6985" + term_id: C6985 + term_version: 20.05a + +malignant_lymphoma_centroblastic_diffuse: + common: + description: >- + A B-cell non-Hodgkin lymphoma composed of large noncleaved cells. This is a + subtype of diffuse large B-cell non-Hodgkin lymphoma. + termDef: + term: >- + Centroblastic Lymphoma + source: NCIt + cde_id: C4074 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4074" + term_id: C4074 + term_version: 20.05a + +malignant_lymphoma_centroblastic_follicular: + common: + description: >- + An antiquated term that refers to a follicular non-Hodgkin lymphoma composed + predominantly of large B-lymphocytes. + termDef: + term: >- + Malignant Lymphoma Centroblastic, Follicular + source: NCIt + cde_id: C8994 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8994" + term_id: C8994 + term_version: 20.05a + +malignant_lymphoma_centroblastic_nos: + common: + description: >- + A B-cell non-Hodgkin lymphoma composed of large noncleaved cells. This is a + subtype of diffuse large B-cell non-Hodgkin lymphoma. + termDef: + term: >- + Centroblastic Lymphoma + source: NCIt + cde_id: C4074 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4074" + term_id: C4074 + term_version: 20.05a + +malignant_lymphoma_centroblasticcentrocytic_diffuse: + common: + description: >- + Diffuse Centroblastic-Centrocytic Lymphoma + termDef: + term: >- + Diffuse Centroblastic-Centrocytic Lymphoma + source: NCIt + cde_id: C4338 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4338" + term_id: C4338 + term_version: 20.05a + +malignant_lymphoma_centroblasticcentrocytic_follicular: + common: + description: >- + A neoplasm of follicle centre B cells which has at least a partial follicular + pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas + in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, + follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending + on the percentage of the large lymphocytes present. The vast majority of cases + (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates + with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade + 3 is more aggressive (adapted from WHO, 2001). + termDef: + term: >- + Follicular Lymphoma + source: NCIt + cde_id: C3209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3209" + term_id: C3209 + term_version: 20.05a + +malignant_lymphoma_centroblasticcentrocytic_nos: + common: + description: >- + Diffuse Centroblastic-Centrocytic Lymphoma + termDef: + term: >- + Diffuse Centroblastic-Centrocytic Lymphoma + source: NCIt + cde_id: C4338 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4338" + term_id: C4338 + term_version: 20.05a + +malignant_lymphoma_convoluted_cell: + common: + description: >- + Malignant Lymphoma, Convoluted + termDef: + term: >- + Malignant Lymphoma, Convoluted + source: NCIt + cde_id: C27821 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27821" + term_id: C27821 + term_version: 20.05a + +malignant_lymphoma_diffuse_nos: + common: + description: >- + An antiquated term referring to non-Hodgkin lymphomas with a diffuse architectural + pattern. + termDef: + term: >- + Diffuse Malignant Lymphoma + source: NCIt + cde_id: C27822 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27822" + term_id: C27822 + term_version: 20.05a + +malignant_lymphoma_follicle_center_follicular: + common: + description: >- + A neoplasm of follicle centre B cells which has at least a partial follicular + pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas + in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, + follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending + on the percentage of the large lymphocytes present. The vast majority of cases + (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates + with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade + 3 is more aggressive (adapted from WHO, 2001). + termDef: + term: >- + Follicular Lymphoma + source: NCIt + cde_id: C3209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3209" + term_id: C3209 + term_version: 20.05a + +malignant_lymphoma_follicle_center_nos: + common: + description: >- + A neoplasm of follicle centre B cells which has at least a partial follicular + pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas + in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, + follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending + on the percentage of the large lymphocytes present. The vast majority of cases + (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates + with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade + 3 is more aggressive (adapted from WHO, 2001). + termDef: + term: >- + Follicular Lymphoma + source: NCIt + cde_id: C3209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3209" + term_id: C3209 + term_version: 20.05a + +malignant_lymphoma_follicular_nos: + common: + description: >- + A neoplasm of follicle centre B cells which has at least a partial follicular + pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas + in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, + follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending + on the percentage of the large lymphocytes present. The vast majority of cases + (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates + with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade + 3 is more aggressive (adapted from WHO, 2001). + termDef: + term: >- + Follicular Lymphoma + source: NCIt + cde_id: C3209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3209" + term_id: C3209 + term_version: 20.05a + +malignant_lymphoma_histiocytic_diffuse: + common: + description: >- + Malignant Lymphoma, Histiocytic, Diffuse + termDef: + term: >- + Malignant Lymphoma, Histiocytic, Diffuse + source: NCIt + cde_id: C27099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27099" + term_id: C27099 + term_version: 20.05a + +malignant_lymphoma_histiocytic_nodular: + common: + description: >- + A follicular lymphoma which contains more than 15 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 3 Follicular Lymphoma + source: NCIt + cde_id: C3460 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3460" + term_id: C3460 + term_version: 20.05a + +malignant_lymphoma_histiocytic_nos: + common: + description: >- + A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly + large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin + lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic + lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities + include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large + B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary + cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell + lymphoma. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma + source: NCIt + cde_id: C8851 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8851" + term_id: C8851 + term_version: 20.05a + +malignant_lymphoma_hodgkin: + common: + description: >- + A lymphoma, previously known as Hodgkin's disease, characterized by the presence + of large tumor cells in an abundant admixture of nonneoplastic cells. There + are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and + classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. + termDef: + term: >- + Hodgkin Lymphoma + source: NCIt + cde_id: C9357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9357" + term_id: C9357 + term_version: 20.05a + +malignant_lymphoma_immunoblastic_nos: + common: + description: >- + A diffuse large B-cell lymphoma characterized by the presence of immunoblasts + with uniformly round-to-oval nuclei, a prominent nucleolus, and abundant cytoplasm. + termDef: + term: >- + Immunoblastic Lymphoma + source: NCIt + cde_id: C3461 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3461" + term_id: C3461 + term_version: 20.05a + +malignant_lymphoma_large_bcell_diffuse_centroblastic_nos: + common: + description: >- + A B-cell non-Hodgkin lymphoma composed of large noncleaved cells. This is a + subtype of diffuse large B-cell non-Hodgkin lymphoma. + termDef: + term: >- + Centroblastic Lymphoma + source: NCIt + cde_id: C4074 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4074" + term_id: C4074 + term_version: 20.05a + +malignant_lymphoma_large_bcell_diffuse_immunoblastic_nos: + common: + description: >- + A diffuse large B-cell lymphoma characterized by the presence of immunoblasts + with uniformly round-to-oval nuclei, a prominent nucleolus, and abundant cytoplasm. + termDef: + term: >- + Immunoblastic Lymphoma + source: NCIt + cde_id: C3461 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3461" + term_id: C3461 + term_version: 20.05a + +malignant_lymphoma_large_bcell_diffuse_nos: + common: + description: >- + A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly + large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin + lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic + lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities + include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large + B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary + cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell + lymphoma. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma + source: NCIt + cde_id: C8851 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8851" + term_id: C8851 + term_version: 20.05a + +malignant_lymphoma_large_bcell_nos: + common: + description: >- + A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly + large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin + lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic + lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities + include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large + B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary + cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell + lymphoma. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma + source: NCIt + cde_id: C8851 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8851" + term_id: C8851 + term_version: 20.05a + +malignant_lymphoma_large_cell_cleaved_and_noncleaved: + common: + description: >- + A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly + large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin + lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic + lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities + include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large + B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary + cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell + lymphoma. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma + source: NCIt + cde_id: C8851 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8851" + term_id: C8851 + term_version: 20.05a + +malignant_lymphoma_large_cell_cleaved_diffuse: + common: + description: >- + Antiquated term describing non-Hodgkin lymphomas that are usually diffuse and + are composed of large cells with irregular nuclei, invisible nucleoli and a + small amount of cytoplasm. This morphologic category includes both mature B- + and mature T-cell lymphomas. + termDef: + term: >- + Malignant Lymphoma, Large Cell, Cleaved + source: NCIt + cde_id: C27265 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27265" + term_id: C27265 + term_version: 20.05a + +malignant_lymphoma_large_cell_cleaved_nos: + common: + description: >- + Antiquated term describing non-Hodgkin lymphomas that are usually diffuse and + are composed of large cells with irregular nuclei, invisible nucleoli and a + small amount of cytoplasm. This morphologic category includes both mature B- + and mature T-cell lymphomas. + termDef: + term: >- + Malignant Lymphoma, Large Cell, Cleaved + source: NCIt + cde_id: C27265 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27265" + term_id: C27265 + term_version: 20.05a + +malignant_lymphoma_large_cell_diffuse_nos: + common: + description: >- + A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly + large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin + lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic + lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities + include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large + B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary + cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell + lymphoma. + termDef: + term: >- + Diffuse Large B-Cell Lymphoma + source: NCIt + cde_id: C8851 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8851" + term_id: C8851 + term_version: 20.05a + +malignant_lymphoma_large_cell_follicular_nos: + common: + description: >- + A follicular lymphoma which contains more than 15 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 3 Follicular Lymphoma + source: NCIt + cde_id: C3460 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3460" + term_id: C3460 + term_version: 20.05a + +malignant_lymphoma_large_cell_immunoblastic: + common: + description: >- + A diffuse large B-cell lymphoma characterized by the presence of immunoblasts + with uniformly round-to-oval nuclei, a prominent nucleolus, and abundant cytoplasm. + termDef: + term: >- + Immunoblastic Lymphoma + source: NCIt + cde_id: C3461 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3461" + term_id: C3461 + term_version: 20.05a + +malignant_lymphoma_large_cell_noncleaved_diffuse: + common: + description: >- + Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells. The + vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large + B-cell lymphomas). + termDef: + term: >- + Malignant Lymphoma, Non-Cleaved, Diffuse + source: NCIt + cde_id: C27266 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27266" + term_id: C27266 + term_version: 20.05a + +malignant_lymphoma_large_cell_noncleaved_follicular: + common: + description: >- + A follicular lymphoma which contains more than 15 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 3 Follicular Lymphoma + source: NCIt + cde_id: C3460 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3460" + term_id: C3460 + term_version: 20.05a + +malignant_lymphoma_large_cell_noncleaved_nos: + common: + description: >- + Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells. The + vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large + B-cell lymphomas). + termDef: + term: >- + Malignant Lymphoma, Non-Cleaved, Diffuse + source: NCIt + cde_id: C27266 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27266" + term_id: C27266 + term_version: 20.05a + +malignant_lymphoma_large_cell_nos: + common: + description: >- + An antiquated term that refers to a morphologic variant of non-Hodgkin lymphoma + which is composed predominantly or exclusively of large neoplastic lymphocytes. + termDef: + term: >- + Malignant Lymphoma, Large Cell Type + source: NCIt + cde_id: C27823 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27823" + term_id: C27823 + term_version: 20.05a + +malignant_lymphoma_large_cleaved_cell_follicular: + common: + description: >- + A follicular lymphoma which contains more than 15 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 3 Follicular Lymphoma + source: NCIt + cde_id: C3460 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3460" + term_id: C3460 + term_version: 20.05a + +malignant_lymphoma_large_cleaved_cell_nos: + common: + description: >- + Antiquated term describing non-Hodgkin lymphomas that are usually diffuse and + are composed of large cells with irregular nuclei, invisible nucleoli and a + small amount of cytoplasm. This morphologic category includes both mature B- + and mature T-cell lymphomas. + termDef: + term: >- + Malignant Lymphoma, Large Cell, Cleaved + source: NCIt + cde_id: C27265 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27265" + term_id: C27265 + term_version: 20.05a + +malignant_lymphoma_lymphoblastic_nos: + common: + description: >- + A lymphoma composed of immature small to medium-sized precursor lymphoid cells + (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma. + termDef: + term: >- + Lymphoblastic Lymphoma + source: NCIt + cde_id: C9360 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9360" + term_id: C9360 + term_version: 20.05a + +malignant_lymphoma_lymphocytic_diffuse_nos: + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +malignant_lymphoma_lymphocytic_intermediate_differentiation_diffuse: + common: + description: >- + An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium + sized B-lymphocytes (centrocytes). Most patients present with advanced stage + disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The + gastrointestinal tract is the most commonly affected extranodal site by this + type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) + resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin + D1 mRNA. + termDef: + term: >- + Mantle Cell Lymphoma + source: NCIt + cde_id: C4337 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4337" + term_id: C4337 + term_version: 20.05a + +malignant_lymphoma_lymphocytic_nodular_nos: + common: + description: >- + A neoplasm of follicle centre B cells which has at least a partial follicular + pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas + in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, + follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending + on the percentage of the large lymphocytes present. The vast majority of cases + (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates + with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade + 3 is more aggressive (adapted from WHO, 2001). + termDef: + term: >- + Follicular Lymphoma + source: NCIt + cde_id: C3209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3209" + term_id: C3209 + term_version: 20.05a + +malignant_lymphoma_lymphocytic_nos: + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +malignant_lymphoma_lymphocytic_poorly_differentiated_nodular: + common: + description: >- + A follicular lymphoma which contains up to 5 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 1 Follicular Lymphoma + source: NCIt + cde_id: C3465 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3465" + term_id: C3465 + term_version: 20.05a + +malignant_lymphoma_lymphocytic_well_differentiated_diffuse: + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +malignant_lymphoma_lymphoplasmacytic: + common: + description: >- + A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma + cells involving the bone marrow, lymph nodes, and the spleen. The majority of + patients have a serum IgM paraprotein. + termDef: + term: >- + Lymphoplasmacytic Lymphoma + source: NCIt + cde_id: C3212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3212" + term_id: C3212 + term_version: 20.05a + +malignant_lymphoma_lymphoplasmacytoid: + common: + description: >- + A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma + cells involving the bone marrow, lymph nodes, and the spleen. The majority of + patients have a serum IgM paraprotein. + termDef: + term: >- + Lymphoplasmacytic Lymphoma + source: NCIt + cde_id: C3212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3212" + term_id: C3212 + term_version: 20.05a + +malignant_lymphoma_mixed_cell_type_follicular: + common: + description: >- + A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic + field. + termDef: + term: >- + Grade 2 Follicular Lymphoma + source: NCIt + cde_id: C8968 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8968" + term_id: C8968 + term_version: 20.05a + +malignant_lymphoma_mixed_cell_type_nodular: + common: + description: >- + A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic + field. + termDef: + term: >- + Grade 2 Follicular Lymphoma + source: NCIt + cde_id: C8968 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8968" + term_id: C8968 + term_version: 20.05a + +malignant_lymphoma_mixed_lymphocytichistiocytic_nodular: + common: + description: >- + A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic + field. + termDef: + term: >- + Grade 2 Follicular Lymphoma + source: NCIt + cde_id: C8968 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8968" + term_id: C8968 + term_version: 20.05a + +malignant_lymphoma_mixed_small_cleaved_and_large_cell_follicular: + common: + description: >- + A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic + field. + termDef: + term: >- + Grade 2 Follicular Lymphoma + source: NCIt + cde_id: C8968 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8968" + term_id: C8968 + term_version: 20.05a + +malignant_lymphoma_nodular_nos: + common: + description: >- + A neoplasm of follicle centre B cells which has at least a partial follicular + pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas + in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, + follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending + on the percentage of the large lymphocytes present. The vast majority of cases + (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates + with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade + 3 is more aggressive (adapted from WHO, 2001). + termDef: + term: >- + Follicular Lymphoma + source: NCIt + cde_id: C3209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3209" + term_id: C3209 + term_version: 20.05a + +malignant_lymphoma_noncleaved_cell_nos: + common: + description: >- + Malignant Lymphoma, Non-Cleaved Cell Type + termDef: + term: >- + Malignant Lymphoma, Non-Cleaved Cell Type + source: NCIt + cde_id: C27258 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27258" + term_id: C27258 + term_version: 20.05a + +malignant_lymphoma_noncleaved_diffuse_nos: + common: + description: >- + Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells. The + vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large + B-cell lymphomas). + termDef: + term: >- + Malignant Lymphoma, Non-Cleaved, Diffuse + source: NCIt + cde_id: C27266 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27266" + term_id: C27266 + term_version: 20.05a + +malignant_lymphoma_noncleaved_nos: + common: + description: >- + Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells. The + vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large + B-cell lymphomas). + termDef: + term: >- + Malignant Lymphoma, Non-Cleaved, Diffuse + source: NCIt + cde_id: C27266 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27266" + term_id: C27266 + term_version: 20.05a + +malignant_lymphoma_nonhodgkin_nos: + common: + description: >- + Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin + lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can + occur at any age, and usually presents as a localized or generalized lymphadenopathy + associated with fever and weight loss. The clinical course varies according + to the morphologic type. NHL is clinically classified as indolent, aggressive, + or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage. + termDef: + term: >- + Non-Hodgkin Lymphoma + source: NCIt + cde_id: C3211 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3211" + term_id: C3211 + term_version: 20.05a + +malignant_lymphoma_nos: + common: + description: >- + A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which + involves the lymph nodes, bone marrow and/or extranodal sites. This category + includes Non-Hodgkin lymphomas and Hodgkin lymphomas. + termDef: + term: >- + Lymphoma + source: NCIt + cde_id: C3208 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3208" + term_id: C3208 + term_version: 20.05a + +malignant_lymphoma_plasmacytoid: + common: + description: >- + A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma + cells involving the bone marrow, lymph nodes, and the spleen. The majority of + patients have a serum IgM paraprotein. + termDef: + term: >- + Lymphoplasmacytic Lymphoma + source: NCIt + cde_id: C3212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3212" + term_id: C3212 + term_version: 20.05a + +malignant_lymphoma_small_b_lymphocytic_nos: + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +malignant_lymphoma_small_cell_diffuse: + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +malignant_lymphoma_small_cell_nos: + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +malignant_lymphoma_small_cleaved_cell_follicular: + common: + description: >- + A follicular lymphoma which contains up to 5 centroblasts per 40X high-power + microscopic field. + termDef: + term: >- + Grade 1 Follicular Lymphoma + source: NCIt + cde_id: C3465 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3465" + term_id: C3465 + term_version: 20.05a + +malignant_lymphoma_small_lymphocytic_diffuse: + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +malignant_lymphoma_small_lymphocytic_nos: + common: + description: >- + A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in + the lymph nodes. When the lymphoid process predominantly involves the bone + marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, + 2001) + termDef: + term: >- + Small Lymphocytic Lymphoma + source: NCIt + cde_id: C7540 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7540" + term_id: C7540 + term_version: 20.05a + +malignant_lymphoma_small_noncleaved_burkitt_type: + common: + description: >- + A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with + basophilic cytoplasm and numerous mitotic figures. It is often associated with + the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three + morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma + with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All + cases express the MYC translocation [t(8;14)]. (WHO, 2001) + termDef: + term: >- + Burkitt Lymphoma + source: NCIt + cde_id: C2912 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2912" + term_id: C2912 + term_version: 20.05a + +malignant_lymphoma_undifferentiated_burkitt_type: + common: + description: >- + A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with + basophilic cytoplasm and numerous mitotic figures. It is often associated with + the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three + morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma + with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All + cases express the MYC translocation [t(8;14)]. (WHO, 2001) + termDef: + term: >- + Burkitt Lymphoma + source: NCIt + cde_id: C2912 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2912" + term_id: C2912 + term_version: 20.05a + +malignant_lymphomatous_polyposis: + common: + description: >- + A clinico-pathological entity reflecting the multiple polyps throughout the + gastrointestinal tract created as a result of involvement by a non-Hodgkin lymphoma. + Typically, mantle cell lymphomas involving the gastrointestinal tract give rise + to multifocal lymphomatous polyposis. Importantly, other histologic subtypes + of non-Hodgkin lymphoma can also produce this clinico-pathological entity. (WHO, + 2000) + termDef: + term: >- + Multifocal Lymphomatous Polyposis + source: NCIt + cde_id: C4339 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4339" + term_id: C4339 + term_version: 20.05a + +malignant_mast_cell_tumor: + common: + description: >- + A rare malignant neoplasm characterized by localized but destructive growth + of a tumor consisting of highly atypical, immature mast cells.(WHO, 2001) + termDef: + term: >- + Mast Cell Sarcoma + source: NCIt + cde_id: C9348 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9348" + term_id: C9348 + term_version: 20.05a + +malignant_mastocytoma: + common: + description: >- + A rare malignant neoplasm characterized by localized but destructive growth + of a tumor consisting of highly atypical, immature mast cells.(WHO, 2001) + termDef: + term: >- + Mast Cell Sarcoma + source: NCIt + cde_id: C9348 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9348" + term_id: C9348 + term_version: 20.05a + +malignant_mastocytosis: + common: + description: >- + Malignant neoplasm originating from mast cells. + termDef: + term: >- + Malignant Mastocytosis + source: NCIt + cde_id: C8991 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8991" + term_id: C8991 + term_version: 20.05a + +malignant_melanoma_in_hutchinson_melanotic_freckle: + common: + description: >- + A melanoma of the skin characterized by single cell infiltration of the papillary + dermis by atypical melanocytes, in a background of lentigo maligna changes. + termDef: + term: >- + Lentigo Maligna Melanoma + source: NCIt + cde_id: C9151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9151" + term_id: C9151 + term_version: 20.05a + +malignant_melanoma_in_junctional_nevus: + common: + description: >- + A melanoma arising from a melanocytic nevus which involves the dermal-epidermal + junction of the skin. + termDef: + term: >- + Melanoma in Junctional Nevus + source: NCIt + cde_id: C4232 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4232" + term_id: C4232 + term_version: 20.05a + +malignant_melanoma_in_precancerous_melanosis: + common: + description: >- + A melanoma arising from an atypical intraepithelial melanocytic hyperplasia. + termDef: + term: >- + Malignant Melanoma in Precancerous Melanosis + source: NCIt + cde_id: C66753 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66753" + term_id: C66753 + term_version: 20.05a + +malignant_melanoma_nos: + common: + description: >- + A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. + Most often, melanomas arise in the skin (cutaneous melanomas) and include the + following histologic subtypes: superficial spreading melanoma, nodular melanoma, + acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas + may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas + may also arise in other anatomic sites including the gastrointestinal system, + eye, urinary tract, and reproductive system. Melanomas frequently metastasize + to lymph nodes, liver, lungs, and brain. + termDef: + term: >- + Melanoma + source: NCIt + cde_id: C3224 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3224" + term_id: C3224 + term_version: 20.05a + +malignant_melanoma_regressing: + common: + description: >- + A skin lesion characterized by the disappearance of the melanoma cells from + the primary melanoma site. The disappearance of the malignant cells is associated + with fibroplasia of the papillary dermis. According to some authors, complete + regression of the primary melanoma may occur in 4-8% of patients. + termDef: + term: >- + Regressing Melanoma + source: NCIt + cde_id: C4228 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4228" + term_id: C4228 + term_version: 20.05a + +malignant_multilocular_cystic_nephroma: + common: + description: >- + A variant of Wilms tumor of the kidney characterized by the presence of cystic + spaces separated by septa. The septa contain immature epithelial cells, immature + stromal cells, and blastema cells. Surgical resection is usually curative. + termDef: + term: >- + Cystic Partially Differentiated Kidney Nephroblastoma + source: NCIt + cde_id: C6897 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6897" + term_id: C6897 + term_version: 20.05a + +malignant_myoepithelioma: + common: + description: >- + An infiltrating malignant tumor characterized by the presence of atypical cells + with myoepithelial differentiation. Representative examples include malignant + breast myoepithelioma and salivary gland myoepithelial carcinoma. + termDef: + term: >- + Malignant Myoepithelioma + source: NCIt + cde_id: C7596 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7596" + term_id: C7596 + term_version: 20.05a + +malignant_peripheral_nerve_sheath_tumor: + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +malignant_peripheral_nerve_sheath_tumor_with_rhabdomyoblastic_differentiation: + common: + description: >- + A malignant peripheral nerve sheath tumor which shows rhabdomyosarcomatous differentiation. + More than half of the patients have neurofibromatosis type 1. The prognosis + is usually poor. + termDef: + term: >- + Malignant Triton Tumor + source: NCIt + cde_id: C4335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4335" + term_id: C4335 + term_version: 20.05a + +malignant_perivascular_epithelial_cell_tumor: + common: + description: >- + A malignant mesenchymal neoplasm arising from the perivascular cells of the + connective and soft tissues. It is characterized by the presence of pericytes + that grow in a circumferential pattern around vessels, and cytologic atypia. + termDef: + term: >- + Malignant Pericytic Neoplasm + source: NCIt + cde_id: C6530 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6530" + term_id: C6530 + term_version: 20.05a + +malignant_reticulosis_nos: + common: + description: >- + An aggressive, predominantly extranodal, mature T-cell non-Hodgkin lymphoma. + It is characterized by an often angiocentric and angiodestructive cellular infiltrate + composed of EBV positive NK/T cells. The nasal cavity is the most common site + of involvement. Patients often present with midfacial destructive lesions (lethal + midline granuloma). The disease may disseminate rapidly to various anatomic + sites including the gastrointestinal tract, skin, testis, and cervical lymph + nodes. It is also known as angiocentric T-cell lymphoma. The term "polymorphic + reticulosis" has been widely used to describe the morphologic changes seen in + this type of lymphoma. However, the latter term may also apply to lymphomatoid + granulomatosis, which is an angiocentric and angiodestructive EBV positive B-cell + lymphoproliferative disorder. + termDef: + term: >- + Nasal Type Extranodal NK/T-Cell Lymphoma + source: NCIt + cde_id: C4684 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4684" + term_id: C4684 + term_version: 20.05a + +malignant_rhabdoid_tumor: + common: + description: >- + An aggressive malignant embryonal neoplasm usually occurring during childhood. It + is characterized by the presence of large cells with abundant cytoplasm, large + eccentric nucleus, and a prominent nucleolus and it is associated with abnormalities + of chromosome 22. It can arise from the central nervous system, kidney, and + the soft tissues. The prognosis is poor. + termDef: + term: >- + Rhabdoid Tumor + source: NCIt + cde_id: C3808 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3808" + term_id: C3808 + term_version: 20.05a + +malignant_schwannoma_nos: + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +malignant_schwannoma_with_rhabdomyoblastic_differentiation: + common: + description: >- + A malignant peripheral nerve sheath tumor which shows rhabdomyosarcomatous differentiation. + More than half of the patients have neurofibromatosis type 1. The prognosis + is usually poor. + termDef: + term: >- + Malignant Triton Tumor + source: NCIt + cde_id: C4335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4335" + term_id: C4335 + term_version: 20.05a + +malignant_tenosynovial_giant_cell_tumor: + common: + description: >- + An uncommon malignant tumor arising from the tendon sheath. Morphologically, + it is characterized by the presence of a cellular infiltrate reminiscent of + a giant cell tumor with prominent malignant characteristics. Recurrent giant + cell tumors with a sarcomatous dedifferentiation are included in this category + as well. + termDef: + term: >- + Malignant Tenosynovial Giant Cell Tumor + source: NCIt + cde_id: C6535 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6535" + term_id: C6535 + term_version: 20.05a + +malignant_teratoma_anaplastic: + common: + description: >- + A teratoma composed exclusively of immature tissues. + termDef: + term: >- + Malignant Teratoma + source: NCIt + cde_id: C4287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4287" + term_id: C4287 + term_version: 20.05a + +malignant_teratoma_intermediate: + common: + description: >- + An immature teratoma characterized by the presence of an intermediate amount + of undifferentiated tissues. + termDef: + term: >- + Intermediate Immature Teratoma + source: NCIt + cde_id: C4288 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4288" + term_id: C4288 + term_version: 20.05a + +malignant_teratoma_trophoblastic: + common: + description: >- + A malignant germ cell tumor which metastasizes widely and produces high levels + of human chorionic gonadotropin. + termDef: + term: >- + Malignant Trophoblastic Teratoma + source: NCIt + cde_id: C66778 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66778" + term_id: C66778 + term_version: 20.05a + +malignant_teratoma_undifferentiated: + common: + description: >- + A teratoma composed exclusively of immature tissues. + termDef: + term: >- + Malignant Teratoma + source: NCIt + cde_id: C4287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4287" + term_id: C4287 + term_version: 20.05a + +malignant_tumor_fusiform_cell_type: + common: + description: >- + A malignant neoplasm characterized by the presence of atypical spindle cells. + termDef: + term: >- + Malignant Spindle Cell Neoplasm + source: NCIt + cde_id: C27091 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27091" + term_id: C27091 + term_version: 20.05a + +malignant_tumor_giant_cell_type: + common: + description: >- + A malignant neoplasm characterized by then presence of atypical giant cells. + termDef: + term: >- + Malignant Giant Cell Neoplasm + source: NCIt + cde_id: C4090 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4090" + term_id: C4090 + term_version: 20.05a + +malignant_tumor_small_cell_type: + common: + description: >- + A malignant neoplasm characterized by the presence of small atypical cells. + termDef: + term: >- + Malignant Tumor, Small Cell Type + source: NCIt + cde_id: C65154 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65154" + term_id: C65154 + term_version: 20.05a + +malignant_tumor_spindle_cell_type: + common: + description: >- + A malignant neoplasm characterized by the presence of atypical spindle cells. + termDef: + term: >- + Malignant Spindle Cell Neoplasm + source: NCIt + cde_id: C27091 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27091" + term_id: C27091 + term_version: 20.05a + +malt_lymphoma: + common: + description: >- + An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes + (centrocyte-like cells). The gastrointestinal tract is the most common site + of involvement. Other common sites of involvement include lung, head and neck, + ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated + with the presence of H. pylori infection. (WHO, 2001) + termDef: + term: >- + Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue + source: NCIt + cde_id: C3898 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3898" + term_id: C3898 + term_version: 20.05a + +malt1: + common: + description: >- + This gene plays a role in signal transduction and in the pathology of mucosa-associated + lymphoid tissue lymphomas. + termDef: + term: >- + MALT1 Gene + source: NCIt + cde_id: C60671 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C60671" + term_id: C60671 + term_version: 20.10d + +malta: + common: + description: >- + A country in southern Europe, occupying islands in the Mediterranean Sea, south + of Sicily (Italy). + termDef: + term: >- + Malta + source: NCIt + cde_id: C16817 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16817" + term_id: C16817 + term_version: 19.12e + +maml2: + common: + description: >- + This gene plays a role in transcriptional regulation and signal transduction. + termDef: + term: >- + MAML2 Gene + source: NCIt + cde_id: C95456 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95456" + term_id: C95456 + term_version: 20.10d + +maml3: + common: + description: >- + This gene plays a role in both transcriptional activation and signaling. + termDef: + term: >- + MAML3 Gene + source: NCIt + cde_id: C117094 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C117094" + term_id: C117094 + term_version: 20.10d + +mandible: + common: + description: >- + The lower jaw bone holding the lower teeth. + termDef: + term: >- + Mandible + source: NCIt + cde_id: C12290 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12290" + term_id: C12290 + term_version: 20.05a + +manec: + common: + description: >- + A carcinoma that arises from the digestive system and is characterized by the + presence of a malignant glandular epithelial component and a malignant neuroendocrine + component. At least 30% of either component should be present for the diagnosis + to be made. + termDef: + term: >- + Digestive System Mixed Adenoneuroendocrine Carcinoma + source: NCIt + cde_id: C95406 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95406" + term_id: C95406 + term_version: 20.05a + +manelimab: + common: + description: >- + A monoclonal antibody directed against the immunosuppressive ligand programmed + cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + manelimab specifically targets and binds to PD-L1, blocking its binding to and + activation of its receptor programmed death 1 (PD-1). This reverses T-cell inactivation + caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated + anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed + by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses + the immune system and results in immune evasion. PD-1, a transmembrane protein + belonging to the immunoglobulin superfamily expressed on activated T-cells, + is a negative regulator of the immune system that limits the expansion and survival + of CD8-positive T-cells. + termDef: + term: >- + Manelimab + source: NCIt + cde_id: C156741 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156741" + term_id: C156741 + term_version: 20.10d + +mantle_cell_lymphoma_includes_all_variants_blastic_pleomorphic_small_cell: + common: + description: >- + An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium + sized B-lymphocytes (centrocytes). Most patients present with advanced stage + disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The + gastrointestinal tract is the most commonly affected extranodal site by this + type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) + resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin + D1 mRNA. + termDef: + term: >- + Mantle Cell Lymphoma + source: NCIt + cde_id: C4337 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4337" + term_id: C4337 + term_version: 20.05a + +mantle_zone_lymphoma: + common: + description: >- + An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium + sized B-lymphocytes (centrocytes). Most patients present with advanced stage + disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The + gastrointestinal tract is the most commonly affected extranodal site by this + type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) + resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin + D1 mRNA. + termDef: + term: >- + Mantle Cell Lymphoma + source: NCIt + cde_id: C4337 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4337" + term_id: C4337 + term_version: 20.05a + +map2k1: + common: + description: >- + This gene plays a role in signal transduction and regulation of transcription. + It is also involved in cell differentiation, growth and proliferation. + termDef: + term: >- + MAP2K1 Gene + source: NCIt + cde_id: C21222 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21222" + term_id: C21222 + term_version: 20.10d + +map2k2: + common: + description: >- + This gene plays a role in both protein phosphorylation and signal transduction. + termDef: + term: >- + MAP2K2 Gene + source: NCIt + cde_id: C106606 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106606" + term_id: C106606 + term_version: 20.10d + +map2k4: + common: + description: >- + This gene is involved in MAPK signaling. + termDef: + term: >- + MAP2K4 Gene + source: NCIt + cde_id: C97674 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97674" + term_id: C97674 + term_version: 20.10d + +map3k1: + common: + description: >- + This gene plays a role in mediating cellular responses to growth factors, metabolic + stimuli and mitogens. + termDef: + term: >- + MAP3K1 Gene + source: NCIt + cde_id: C24572 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24572" + term_id: C24572 + term_version: 20.10d + +map3k13: + common: + description: >- + This gene is involved in both protein phosphorylation and signaling. + termDef: + term: >- + MAP3K13 Gene + source: NCIt + cde_id: C102523 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102523" + term_id: C102523 + term_version: 20.10d + +mapk1: + common: + description: >- + This gene plays a role in signal transduction and positive regulation of the + cell cycle. + termDef: + term: >- + MAPK1 Gene + source: NCIt + cde_id: C21227 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21227" + term_id: C21227 + term_version: 20.10d + +marginal_zone_bcell_lymphoma_nos: + common: + description: >- + A usually indolent mature B-cell lymphoma, arising from the marginal zone of + lymphoid tissues. It is characterized by the presence of small to medium sized + atypical lymphocytes. It comprises three entities, according to the anatomic + sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated + lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, + and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph + nodes without evidence of extranodal disease; and splenic marginal zone B-cell + lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, + and often the peripheral blood. + termDef: + term: >- + Marginal Zone Lymphoma + source: NCIt + cde_id: C4341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4341" + term_id: C4341 + term_version: 20.05a + +marginal_zone_lymphoma_nos: + common: + description: >- + A usually indolent mature B-cell lymphoma, arising from the marginal zone of + lymphoid tissues. It is characterized by the presence of small to medium sized + atypical lymphocytes. It comprises three entities, according to the anatomic + sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated + lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, + and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph + nodes without evidence of extranodal disease; and splenic marginal zone B-cell + lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, + and often the peripheral blood. + termDef: + term: >- + Marginal Zone Lymphoma + source: NCIt + cde_id: C4341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4341" + term_id: C4341 + term_version: 20.05a + +marijuana: + common: + description: >- + Any part of, or extract from, the female hemp plant Cannabis sativa. Marijuana + contains cannabinoids, substances with hallucinogenic, psychoactive, and addictive + properties. This agent has potential use for treating cancer pain and cachexia. + termDef: + term: >- + Marijuana + source: NCIt + cde_id: C26659 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26659" + term_id: C26659 + term_version: 19.12e + +marijuana_smoke: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced by direct or nearby use of a vaporized or combusted product + made from the leaves and flowers of the cannabis plant. + termDef: + term: >- + Marijuana Smoke Exposure + source: NCIt + cde_id: C164091 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164091" + term_id: C164091 + term_version: 19.12e + +marshall_islands: + common: + description: >- + A group of atolls and reefs in the North Pacific Ocean, about one-half of the + way from Hawaii to Australia, south of Wake Island and north of Nauru. + termDef: + term: >- + Marshall Islands + source: NCIt + cde_id: C16822 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16822" + term_id: C16822 + term_version: 19.12e + +martinique: + common: + description: >- + An island between the Caribbean Sea and the North Atlantic Ocean, south of Dominica + and north of Saint Lucia. + termDef: + term: >- + Martinique + source: NCIt + cde_id: C16823 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16823" + term_id: C16823 + term_version: 19.12e + +masculinovoblastoma: + common: + description: >- + An ovarian tumor in which the vast majority of the cells (more than 90% of the + tumor cells) resemble steroid hormone-secreting cells. It usually presents with + androgenic manifestations. Approximately one-third of the cases follow a malignant + clinical course. + termDef: + term: >- + Ovarian Steroid Cell Tumor + source: NCIt + cde_id: C4215 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4215" + term_id: C4215 + term_version: 20.05a + +mast_cell_leukaemia: + common: + description: >- + A variant of systemic mastocytosis with involvement of the bone marrow (20% + or more mast cells) and the peripheral blood (mast cells account for 10% or + more of peripheral blood white cells). (WHO, 2001) + termDef: + term: >- + Mast Cell Leukemia + source: NCIt + cde_id: C3169 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3169" + term_id: C3169 + term_version: 20.05a + +mast_cell_sarcoma: + common: + description: >- + A rare malignant neoplasm characterized by localized but destructive growth + of a tumor consisting of highly atypical, immature mast cells.(WHO, 2001) + termDef: + term: >- + Mast Cell Sarcoma + source: NCIt + cde_id: C9348 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9348" + term_id: C9348 + term_version: 20.05a + +mast_cell_tumor_nos: + common: + description: >- + A heterogeneous group of disorders characterized by the abnormal growth and + accumulation of mast cells in one or more organ systems. Recent data suggest + that most variants of mast cell neoplasms are clonal disorders. (WHO, 2001) + termDef: + term: >- + Mast Cell Neoplasm + source: NCIt + cde_id: C9295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9295" + term_id: C9295 + term_version: 20.05a + +mastocytoma_nos: + common: + description: >- + A localized tumor composed of sheets of mast cells without atypia. It includes + the cutaneous mastocytoma which involves the dermis and subcutaneous tissue, + and the extracutaneous mastocytoma. Most cases of extracutaneous mastocytoma + have been reported in the lung. + termDef: + term: >- + Mastocytoma + source: NCIt + cde_id: C9303 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9303" + term_id: C9303 + term_version: 20.05a + +maternal_aunt: + common: + description: >- + A female relative who is a sibling of the biological mother, and who both share + a common ancestor. + termDef: + term: >- + Biological Maternal Aunt + source: NCIt + cde_id: C96575 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96575" + term_id: C96575 + term_version: 19.12e + +maternal_first_cousin: + common: + description: >- + A relative who is the offspring of a sibling of the biological mother and thus + sharing a common ancestor. + termDef: + term: >- + Biological Maternal Cousin + source: NCIt + cde_id: C96576 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96576" + term_id: C96576 + term_version: 19.12e + +maternal_first_cousin_once_removed: + common: + description: >- + A child of one's first cousin who is related by lineage through the mother's + side of the family. + termDef: + term: >- + Maternal First Cousin Once Removed + source: NCIt + cde_id: C165851 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165851" + term_id: C165851 + term_version: 19.12e + +maternal_grandfather: + common: + description: >- + A male relative who is the biological father of the biological mother. + termDef: + term: >- + Biological Maternal Grandfather + source: NCIt + cde_id: C96577 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96577" + term_id: C96577 + term_version: 19.12e + +maternal_grandmother: + common: + description: >- + A female relative who is the biological mother of the biological mother. + termDef: + term: >- + Biological Maternal Grandmother + source: NCIt + cde_id: C96578 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96578" + term_id: C96578 + term_version: 19.12e + +maternal_grandparent: + common: + description: >- + A relative who is the biological parent of the biological mother. + termDef: + term: >- + Biological Maternal Grandparent + source: NCIt + cde_id: C111248 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111248" + term_id: C111248 + term_version: 19.12e + +maternal_great_aunt: + common: + description: >- + The aunt of one's mother. + termDef: + term: >- + Maternal Great Aunt + source: NCIt + cde_id: C165853 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165853" + term_id: C165853 + term_version: 19.12e + +maternal_great_grandparent: + common: + description: >- + A parent of one's maternal grandparent. + termDef: + term: >- + Maternal Great Grandparent + source: NCIt + cde_id: C166127 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166127" + term_id: C166127 + term_version: 19.12e + +maternal_great_uncle: + common: + description: >- + The uncle of one's mother. + termDef: + term: >- + Maternal Great Uncle + source: NCIt + cde_id: C165854 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165854" + term_id: C165854 + term_version: 19.12e + +maternal_half_brother: + common: + description: >- + A male sibling who shares the genetic makeup inherited from only the biological + mother. + termDef: + term: >- + Half-brother with Mother as Common Parent + source: NCIt + cde_id: C96656 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96656" + term_id: C96656 + term_version: 19.12e + +maternal_half_sibling: + common: + description: >- + A relative with whom you share a biological mother but you have different fathers. + termDef: + term: >- + Maternal Half Sibling + source: NCIt + cde_id: C166112 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166112" + term_id: C166112 + term_version: 19.12e + +maternal_half_sister: + common: + description: >- + A female sibling who shares the genetic makeup inherited from only the biological + mother. + termDef: + term: >- + Half-sister with Mother as Common Parent + source: NCIt + cde_id: C96658 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96658" + term_id: C96658 + term_version: 19.12e + +maternal_uncle: + common: + description: >- + A male relative who is a sibling of the biological mother, and who both share + a common ancestor. + termDef: + term: >- + Biological Maternal Uncle + source: NCIt + cde_id: C96579 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96579" + term_id: C96579 + term_version: 19.12e + +matrical_carcinoma: + common: + description: >- + A very rare, locally aggressive, malignant neoplasm of the hair follicle. The + majority of the cases arise de novo, however malignant transformation from a + pre-existing pilomatricoma has been reported. It usually presents as a solitary + nodule in the head and neck, upper extremities, or buttocks. Morphologically, + it is characterized by the presence of aggregates of basaloid cells infiltrating + the dermis. Masses of ghost cells are present in the cellular aggregates. Complete + surgical excision is the treatment of choice. If it is not completely removed, + it usually recurs, but it rarely metastasizes to distant anatomic sites. + termDef: + term: >- + Pilomatrical Carcinoma + source: NCIt + cde_id: C4114 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4114" + term_id: C4114 + term_version: 20.05a + +mature_mirna_variant: + common: + description: >- + A ribonucleotide variation in the sequence of a fully processed microRNA. + termDef: + term: >- + Mature miRNA Variant + source: NCIt + cde_id: C165227 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165227" + term_id: C165227 + term_version: 20.10d + +mature_t_all: + common: + description: >- + Mature T-ALL + termDef: + term: >- + Mature T-ALL + source: NCIt + cde_id: C27820 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27820" + term_id: C27820 + term_version: 20.05a + +mature_tcell_lymphoma_nos: + common: + description: >- + A heterogenous category of nodal and extranodal mature T-cell lymphomas that + do not correspond to any of the specifically defined entities of mature T-cell + lymphoma in the 2017 WHO classification. Excluded from this category are tumors + with a T follicular helper (TFH) cell phenotype. Variants include lymphoepithelioid + lymphoma (Lennert lymphoma) and primary EBV-positive nodal T-cell or NK-cell + lymphoma. The follicular variant included in the peripheral T-cell lymphomas, + not otherwise specified, in the 2008 edition of the WHO classification has been + moved to the category of angioimmunoblastic T-cell lymphoma and other nodal + lymphomas of T follicular helper cell origin in the 2017 WHO update. The same + is true for a proportion of cases previously designated as the T-zone variant, + because they usually have a TFH-cell phenotype. (WHO 2017) + termDef: + term: >- + Peripheral T-Cell Lymphoma, Not Otherwise Specified + source: NCIt + cde_id: C4340 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4340" + term_id: C4340 + term_version: 20.05a + +mature_teratoma: + common: + description: >- + A teratoma which may be cystic; it is composed entirely of well differentiated, + adult-type mature tissues, without evidence of fetal-type immature tissues (grade + 0 teratoma). + termDef: + term: >- + Mature Teratoma + source: NCIt + cde_id: C9015 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9015" + term_id: C9015 + term_version: 20.05a + +mauritania: + common: + description: >- + A country in northern Africa, bordering the North Atlantic Ocean, between Senegal, + Western Sahara, and Mali. + termDef: + term: >- + Mauritania + source: NCIt + cde_id: C16826 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16826" + term_id: C16826 + term_version: 19.12e + +mauritius: + common: + description: >- + A country in southern Africa, occupying an island in the Indian Ocean, off the + coast of Madagascar, east of Reunion. + termDef: + term: >- + Mauritius + source: NCIt + cde_id: C16827 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16827" + term_id: C16827 + term_version: 19.12e + +max: + common: + description: >- + This gene is involved in transcriptional regulation and plays a role in the + mediation of DNA-protein interactions. + termDef: + term: >- + MAX Gene + source: NCIt + cde_id: C18576 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18576" + term_id: C18576 + term_version: 20.10d + +maxillary_sinus: + common: + description: >- + A pyramidal-shaped, thin-walled, air-filled cavity located in the maxilla. It + is lined by mucus membrane and periosteum (mucoperiosteum) which contains cilia. + It is adjacent to the nasal cavity and communicates with the middle meatus of + the nose. It is the largest paranasal sinus and is composed of three recesses: + alveolar, zygomatic, and infraorbital. + termDef: + term: >- + Maxillary Sinus + source: NCIt + cde_id: C12275 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12275" + term_id: C12275 + term_version: 20.05a + +mayotte: + common: + description: >- + A country in southern Africa, occupying an island in the Mozambique Channel, + about one-half of the way from northern Madagascar to northern Mozambique, southeast + of Comoros. + termDef: + term: >- + Mayotte + source: NCIt + cde_id: C16828 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16828" + term_id: C16828 + term_version: 19.12e + +mb21d2: + common: + description: >- + This gene plays a role in protein-protein interactions. + termDef: + term: >- + MB21D2 Gene + source: NCIt + cde_id: C132170 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132170" + term_id: C132170 + term_version: 20.10d + +mcl1_inhibitor_abbv467: + common: + description: >- + An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid + cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic + activities. Upon administration, MCL-1 inhibitor ABBV-467 targets and binds + to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain + pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. + Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) + family of proteins, is upregulated in cancer cells and promotes tumor cell survival. + termDef: + term: >- + MCL-1 Inhibitor ABBV-467 + source: NCIt + cde_id: C174400 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174400" + term_id: C174400 + term_version: 20.10d + +mdm2: + common: + description: >- + This gene plays a role in several cellular processes related to cellular viability; + including the cell cycle and apoptosis. + termDef: + term: >- + MDM2 Gene + source: NCIt + cde_id: C18345 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18345" + term_id: C18345 + term_version: 20.10d + +mdm2_inhibitor_amgmds3: + common: + description: >- + An inhibitor of MDM2 (murine double minute 2), with potential antineoplastic + activity. Upon administration, MDM2 inhibitor AMGMDS3 binds to the MDM2 protein + and prevents its binding to the transcriptional activation domain of the tumor + suppressor protein p53. By preventing this MDM2-p53 interaction, the transcriptional + activity of p53 is restored. This leads to p53-mediated induction of tumor cell + apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, + is overexpressed in cancer cells; it plays a key role in cancer cell proliferation + and survival. + termDef: + term: >- + MDM2 Inhibitor AMGMDS3 + source: NCIt + cde_id: C171616 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171616" + term_id: C171616 + term_version: 20.10d + +mdm4: + common: + description: >- + This gene plays a role in both cell cycle arrest and the inhibition of apoptosis. + termDef: + term: >- + MDM4 Gene + source: NCIt + cde_id: C88218 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C88218" + term_id: C88218 + term_version: 20.10d + +mds2: + common: + description: >- + This gene plays a role in myelodysplastic syndrome. + termDef: + term: >- + MDS2 Gene + source: NCIt + cde_id: C97615 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97615" + term_id: C97615 + term_version: 20.10d + +meckel_diverticulum: + common: + description: >- + A congenital pouch in the distal ileum. It may cause painless rectal bleeding + and bowel obstruction. + termDef: + term: >- + Meckel Diverticulum + source: NCIt + cde_id: C12264 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12264" + term_id: C12264 + term_version: 20.05a + +mecom: + common: + description: >- + This gene plays a role in transcriptional regulation, histone methylation and + leukemogenesis. + termDef: + term: >- + MECOM Gene + source: NCIt + cde_id: C18392 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18392" + term_id: C18392 + term_version: 20.10d + +med12: + common: + description: >- + This gene plays a role in the regulation of RNA polymerase II-dependent transcription. + termDef: + term: >- + MED12 Gene + source: NCIt + cde_id: C98210 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98210" + term_id: C98210 + term_version: 20.10d + +mediastinal: + common: + description: >- + A lymph node located in the mediastinum. Mediastinal lymph nodes are arranged + in three groups, one on the lateral, another on the medial, and a third on the + anterior aspect of the vessels; the third group is, however, sometimes absent. + termDef: + term: >- + Mediastinal Lymph Node + source: NCIt + cde_id: C33073 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33073" + term_id: C33073 + term_version: 20.10d + +mediastinal_thymic_large_bcell_lymphoma: + common: + description: >- + A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically + it is characterized by a massive diffuse lymphocytic proliferation associated + with compartmentalizing fibrosis. Response to intensive chemotherapy, with + or without radiotherapy, is usually good. (WHO, 2001) + termDef: + term: >- + Primary Mediastinal (Thymic) Large B-Cell Lymphoma + source: NCIt + cde_id: C9280 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9280" + term_id: C9280 + term_version: 20.05a + +mediastinum: + common: + description: >- + A group of organs surrounded by loose connective tissue, separating the two + pleural sacs, between the sternum anteriorly and the vertebral column posteriorly + as well as from the thoracic inlet superiorly to the diaphragm inferiorly. The + mediastinum contains the heart and pericardium, the bases of the great vessels, + the trachea and bronchi, esophagus, thymus, lymph nodes, thoracic duct, phrenic + and vagus nerves, and other structures and tissues. + termDef: + term: >- + Mediastinum + source: NCIt + cde_id: C12748 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12748" + term_id: C12748 + term_version: 20.05a + +mediastinum_nos: + common: + description: >- + A group of organs surrounded by loose connective tissue, separating the two + pleural sacs, between the sternum anteriorly and the vertebral column posteriorly + as well as from the thoracic inlet superiorly to the diaphragm inferiorly. The + mediastinum contains the heart and pericardium, the bases of the great vessels, + the trachea and bronchi, esophagus, thymus, lymph nodes, thoracic duct, phrenic + and vagus nerves, and other structures and tissues. + termDef: + term: >- + Mediastinum + source: NCIt + cde_id: C12748 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12748" + term_id: C12748 + term_version: 20.05a + +medical_record: + common: + description: >- + A chronological written account of a patient's examination and treatment that + includes the patient's medical history and complaints, the physician's physical + findings, the results of diagnostic tests and procedures, and medications and + therapeutic procedures. + termDef: + term: >- + Medical Record + source: NCIt + cde_id: C45258 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45258" + term_id: C45258 + term_version: 19.12e + +mediterranean_lymphoma: + common: + description: >- + A clonal disorder, also known as immunoproliferative small intestinal disease + or Mediterranean lymphoma, characterised by the secretion of a defective alpha + heavy chain. It predominantly affects young people in the Mediterranean region. It + involves the small intestine, and patients usually present with malabsorption + syndrome, abdominal pain, weight loss, and fever. There is extensive villous + atrophy of the small intestinal mucosa, which is heavily infiltrated by small + lymphocytes and plasma cells. The small intestinal morphologic changes are + consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). + termDef: + term: >- + Alpha Heavy Chain Disease + source: NCIt + cde_id: C3132 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3132" + term_id: C3132 + term_version: 20.05a + +medulla_of_adrenal_gland: + common: + description: >- + The inner region of the adrenal gland. The adrenal medulla produces, stores, + and secretes epinephrine and norepinephrine. + termDef: + term: >- + Adrenal Medulla + source: NCIt + cde_id: C12397 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12397" + term_id: C12397 + term_version: 20.05a + +medullary_carcinoma_nos: + common: + description: >- + A term referring to medullary carcinomas which can develop in various anatomic + sites such as the thyroid gland, breast, colon, rectum, and small intestine. + termDef: + term: >- + Medullary Carcinoma, Not Otherwise Specified + source: NCIt + cde_id: C66718 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66718" + term_id: C66718 + term_version: 20.05a + +medullary_carcinoma_with_amyloid_stroma: + common: + description: >- + A medullary thyroid gland carcinoma characterized by the presence of amyloid + stroma. The majority of medullary carcinomas of the thyroid gland are associated + with amyloid deposits. The latter are highlighted with Congo red staining method. + termDef: + term: >- + Thyroid Gland Medullary Carcinoma with Amyloid Stroma + source: NCIt + cde_id: C4193 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4193" + term_id: C4193 + term_version: 20.05a + +medullary_osteosarcoma: + common: + description: >- + A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. + The tumor arises from the medullary portion of the bone. It affects the long + bones and most commonly, the distal femur, proximal tibia, and proximal humerus. + Pain with or without a palpable mass is the most common clinical presentation. + It usually has an aggressive growth and may metastasize through the hematogenous + route. The lung is the most frequent site of metastasis. + termDef: + term: >- + Conventional Osteosarcoma + source: NCIt + cde_id: C35870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35870" + term_id: C35870 + term_version: 20.05a + +medulloblastoma_classic: + common: + description: >- + A medulloblastoma composed of malignant cells with hyperchromatic nucleus and + scanty cytoplasm. Homer Wright rosettes may be present. + termDef: + term: >- + Classic Medulloblastoma + source: NCIt + cde_id: C54039 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54039" + term_id: C54039 + term_version: 20.05a + +medulloblastoma_group_3: + common: + description: >- + Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog + (SHH) pathway. MYC amplifications may be present. TP53 mutations are absent. + Patients in this group are usually young children. The overall survival is the + worst among all the molecular groups. + termDef: + term: >- + Medulloblastoma, Non-WNT/Non-SHH, Group 3 + source: NCIt + cde_id: C129445 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129445" + term_id: C129445 + term_version: 20.05a + +medulloblastoma_group_4: + common: + description: >- + Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog + (SHH) pathway. MYC amplifications are absent. TP53 mutations are absent. Chromosome + 17 abnormalities may be present. + termDef: + term: >- + Medulloblastoma, Non-WNT/Non-SHH, Group 4 + source: NCIt + cde_id: C129446 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129446" + term_id: C129446 + term_version: 20.05a + +medulloblastoma_nonwntnonshh: + common: + description: >- + Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog + (SHH) pathway. TP53 mutations are absent. This molecular subtype includes medulloblastomas + numerically designated as "group 3" and "group 4". + termDef: + term: >- + Medulloblastoma, Non-WNT/Non-SHH + source: NCIt + cde_id: C129444 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129444" + term_id: C129444 + term_version: 20.05a + +medulloblastoma_nos: + common: + description: >- + A malignant, invasive embryonal neoplasm arising from the cerebellum or posterior + fossa. It occurs predominantly in children and has the tendency to metastasize + via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, + disturbed gait, lethargy, headache, and vomiting. There are four histologic + variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular + medulloblastoma, and medulloblastoma with extensive nodularity. + termDef: + term: >- + Medulloblastoma + source: NCIt + cde_id: C3222 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3222" + term_id: C3222 + term_version: 20.05a + +medulloblastoma_shhactivated_and_tp53mutant: + common: + description: >- + Medulloblastoma associated with activation of the sonic hedgehog (SHH) pathway + and the presence of TP53 mutations. + termDef: + term: >- + Medulloblastoma, SHH-Activated, TP53-Mutant + source: NCIt + cde_id: C129442 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129442" + term_id: C129442 + term_version: 20.05a + +medulloblastoma_shhactivated_and_tp53wildtype: + common: + description: >- + Medulloblastoma associated with activation of the sonic hedgehog (SHH) pathway + and the absence of TP53 mutations. + termDef: + term: >- + Medulloblastoma, SHH-Activated, TP53-Wildtype + source: NCIt + cde_id: C129443 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129443" + term_id: C129443 + term_version: 20.05a + +medulloblastoma_with_extensive_nodularity: + common: + description: >- + A medulloblastoma characterized by nodularity and neuronal differentiation. + termDef: + term: >- + Medulloblastoma with Extensive Nodularity + source: NCIt + cde_id: C5407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5407" + term_id: C5407 + term_version: 20.05a + +medulloblastoma_wntactivated: + common: + description: >- + A molecular subtype of medulloblastoma associated with activation of the WNT + pathway. TP53 mutations may be present or absent. WNT pathway activation in + medulloblastomas is associated with good outcome. + termDef: + term: >- + Medulloblastoma, WNT-Activated + source: NCIt + cde_id: C129440 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129440" + term_id: C129440 + term_version: 20.05a + +medullocytoma: + common: + description: >- + A rare, WHO grade II cerebellar neoplasm which shows consistent neuronal, variable + astrocytic and focal lipomatous differentiation. It occurs in adults, has a + low proliferative potential and usually has a favorable prognosis. (Adapted + from WHO) + termDef: + term: >- + Cerebellar Liponeurocytoma + source: NCIt + cde_id: C6905 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6905" + term_id: C6905 + term_version: 20.05a + +medulloepithelioma_nos: + common: + description: >- + A rare, unilateral, benign or malignant embryonic neoplasm typically presenting + as a cilliary body mass during childhood. It is composed of medullary epithelial + cells. + termDef: + term: >- + Medulloepithelioma Not Otherwise Specified + source: NCIt + cde_id: C66808 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66808" + term_id: C66808 + term_version: 20.05a + +medullomyoblastoma: + common: + description: >- + A rare malignant embryonal neoplasm arising from the cerebellum. It is characterized + by the morphologic features of a medulloblastoma and the presence of a striated + muscle component. Its clinical behavior is similar to medulloblastoma. + termDef: + term: >- + Medullomyoblastoma with Myogenic Differentiation + source: NCIt + cde_id: C3706 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3706" + term_id: C3706 + term_version: 20.05a + +megakaryocytic_leukemia: + common: + description: >- + An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic + lineage. (WHO, 2001) + termDef: + term: >- + Acute Megakaryoblastic Leukemia + source: NCIt + cde_id: C3170 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3170" + term_id: C3170 + term_version: 20.05a + +megakaryocytic_myelosclerosis: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, + proliferation of atypical megakaryocytes and granulocytes in the bone marrow, + anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001) + termDef: + term: >- + Primary Myelofibrosis + source: NCIt + cde_id: C2862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2862" + term_id: C2862 + term_version: 20.05a + +mek_12_inhibitor_fcn159: + common: + description: >- + An orally bioavailable inhibitor of mitogen-activated protein kinase kinase + (MAP2K, MAPK/ERK kinase, or MEK) 1 and 2, with potential antineoplastic activity. + Upon administration, MEK 1/2 Inhibitor FCN-159 selectively binds to and inhibits + the activity of MEK1 and MEK2, preventing the activation of MEK1/2-dependent + effector proteins and transcription factors, which may result in the inhibition + of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 + are dual-specificity threonine/tyrosine kinases that play key roles in the activation + of the RAS/RAF/MEK/ERK pathway that regulates cell growth. This pathway is often + dysregulated in a variety of tumor cell types through BRAF, KRAS and NRAS mutations. + termDef: + term: >- + MEK 1/2 Inhibitor FCN-159 + source: NCIt + cde_id: C172382 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172382" + term_id: C172382 + term_version: 20.10d + +mek_inhibitor_hl085: + common: + description: >- + An orally bioavailable inhibitor of mitogen-activated protein kinase kinase + (MAP2K, MAPK/ERK kinase, or MEK), with potential antineoplastic activity. Upon + administration, MEK inhibitor HL-085 selectively binds to and inhibits the activity + of MEK, preventing the activation of MEK-dependent effector proteins and transcription + factors, which may result in the inhibition of growth factor-mediated cell signaling + and tumor cell proliferation. MEK, a threonine/tyrosine kinase, plays a key + role in the activation of the RAS/RAF/MEK/ERK pathway that regulates cell growth. + This pathway is often dysregulated in a variety of tumor cell types through + BRAF, KRAS and NRAS mutations. + termDef: + term: >- + MEK Inhibitor HL-085 + source: NCIt + cde_id: C173437 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173437" + term_id: C173437 + term_version: 20.10d + +melanoameloblastoma: + common: + description: >- + A rare neoplasm usually occurring in infants. It is characterized by the presence + of a mixture of melanin-containing epithelial cells and smaller neuroblast-like + cells. It may involve the skull and facial bones, or the epididymis. It usually + has a benign clinical course. + termDef: + term: >- + Melanotic Neuroectodermal Tumor + source: NCIt + cde_id: C3717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3717" + term_id: C3717 + term_version: 20.05a + +melanocytic_nevus: + common: + description: >- + A neoplasm composed of melanocytes that usually appears as a dark spot on the + skin. + termDef: + term: >- + Melanocytic Nevus + source: NCIt + cde_id: C7570 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7570" + term_id: C7570 + term_version: 20.05a + +melanocytoma_eyeball: + common: + description: >- + A benign melanocytic proliferation within or adjacent to the optic disk. It + presents as a pigmented, intraocular tumor. + termDef: + term: >- + Melanocytoma of the Eyeball + source: NCIt + cde_id: C4230 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4230" + term_id: C4230 + term_version: 20.05a + +melanocytoma_nos: + common: + description: >- + A benign melanocytic proliferation without metastatic potential. + termDef: + term: >- + Melanocytoma + source: NCIt + cde_id: C9498 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9498" + term_id: C9498 + term_version: 20.05a + +melanoma: + common: + description: >- + A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. + Most often, melanomas arise in the skin (cutaneous melanomas) and include the + following histologic subtypes: superficial spreading melanoma, nodular melanoma, + acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas + may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas + may also arise in other anatomic sites including the gastrointestinal system, + eye, urinary tract, and reproductive system. Melanomas frequently metastasize + to lymph nodes, liver, lungs, and brain. + termDef: + term: >- + Melanoma + source: NCIt + cde_id: C3224 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3224" + term_id: C3224 + term_version: 19.12e + +melanoma_in_situ: + common: + description: >- + Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. N0: No regional lymph + node metastases. M0: No detectable evidence of distant metastases. (from AJCC + 6th and 7th Eds.) + termDef: + term: >- + Stage 0 Cutaneous Melanoma AJCC v6 and v7 + source: NCIt + cde_id: C8423 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8423" + term_id: C8423 + term_version: 20.05a + +melanoma_malignant_of_soft_parts: + common: + description: >- + A rare malignant neoplasm with melanocytic differentiation characterized by + the presence of polygonal or spindle shaped clear cells. This sarcoma usually + affects the tendons and aponeuroses and is associated with a poor prognosis + due to recurrences and metastases. + termDef: + term: >- + Clear Cell Sarcoma of Soft Tissue + source: NCIt + cde_id: C3745 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3745" + term_id: C3745 + term_version: 20.05a + +melanoma_nos: + common: + description: >- + A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. + Most often, melanomas arise in the skin (cutaneous melanomas) and include the + following histologic subtypes: superficial spreading melanoma, nodular melanoma, + acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas + may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas + may also arise in other anatomic sites including the gastrointestinal system, + eye, urinary tract, and reproductive system. Melanomas frequently metastasize + to lymph nodes, liver, lungs, and brain. + termDef: + term: >- + Melanoma + source: NCIt + cde_id: C3224 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3224" + term_id: C3224 + term_version: 20.05a + +melanotic_medulloblastoma: + common: + description: >- + A rare malignant embryonal neoplasm characterized by the presence of small cells + which resemble the cells of classic medulloblastoma and a minor population of + melanin-forming neuroepithelial cells. It usually has an unfavorable clinical + course. + termDef: + term: >- + Medulloblastoma with Melanotic Differentiation + source: NCIt + cde_id: C9497 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9497" + term_id: C9497 + term_version: 20.05a + +melanotic_mpnst: + common: + description: >- + A rare variant of malignant peripheral nerve sheath tumor. It is characterized + by the presence of malignant cells that contain melanin. + termDef: + term: >- + Malignant Melanotic Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C4748 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4748" + term_id: C4748 + term_version: 20.05a + +melanotic_neuroectodermal_tumor: + common: + description: >- + A rare neoplasm usually occurring in infants. It is characterized by the presence + of a mixture of melanin-containing epithelial cells and smaller neuroblast-like + cells. It may involve the skull and facial bones, or the epididymis. It usually + has a benign clinical course. + termDef: + term: >- + Melanotic Neuroectodermal Tumor + source: NCIt + cde_id: C3717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3717" + term_id: C3717 + term_version: 20.05a + +melanotic_neurofibroma: + common: + description: >- + A rare neurofibroma characterized by the presence of melanin-laden cells and + the absence of atypia. + termDef: + term: >- + Melanotic Neurofibroma + source: NCIt + cde_id: C66841 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66841" + term_id: C66841 + term_version: 20.05a + +melanotic_progonoma: + common: + description: >- + A rare neoplasm usually occurring in infants. It is characterized by the presence + of a mixture of melanin-containing epithelial cells and smaller neuroblast-like + cells. It may involve the skull and facial bones, or the epididymis. It usually + has a benign clinical course. + termDef: + term: >- + Melanotic Neuroectodermal Tumor + source: NCIt + cde_id: C3717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3717" + term_id: C3717 + term_version: 20.05a + +melanotic_psammomatous_mpnst: + common: + description: >- + A malignant peripheral nerve sheath tumor characterized by the presence of malignant + cells that contain melanin and formation of psammoma bodies. + termDef: + term: >- + Melanotic Psammomatous Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C6910 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6910" + term_id: C6910 + term_version: 20.05a + +melanotic_schwannoma: + common: + description: >- + A rare circumscribed, non-encapsulated and grossly pigmented nerve sheath tumor. + It is composed of cells with the immunophenotypic and electron microscopic features + of Schwann cells which contain melanosomes and are positive for melanoma markers. + It usually involves spinal nerve roots but may occur in other locations. It + may be associated with PRKAR1A gene mutation and Carney complex. Malignant behavior + has been reported in a significant number of patients. + termDef: + term: >- + Melanotic Schwannoma + source: NCIt + cde_id: C6970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6970" + term_id: C6970 + term_version: 20.05a + +men1: + common: + description: >- + This gene is involved in transcriptional regulation and has tumor suppressor + activity. + termDef: + term: >- + MEN1 Gene + source: NCIt + cde_id: C18254 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18254" + term_id: C18254 + term_version: 20.10d + +meningeal_melanocytoma: + common: + description: >- + A usually well differentiated melanocytic neoplasm arising from the meninges. + It is characterized by the presence of epithelioid, fusiform, polyhedral, and + spindle melanocytes without evidence of hemorrhage, necrosis, or high mitotic + activity. Presenting symptoms include headache, vomiting, and neurological manifestations. + Complete excision is usually curative. + termDef: + term: >- + Meningeal Melanocytoma + source: NCIt + cde_id: C4662 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4662" + term_id: C4662 + term_version: 20.05a + +meningeal_melanoma: + common: + description: >- + A melanoma that arises from leptomeningeal melanocytes. + termDef: + term: >- + Meningeal Melanoma + source: NCIt + cde_id: C5317 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5317" + term_id: C5317 + term_version: 20.05a + +meningeal_melanomatosis: + common: + description: >- + A meningeal melanoma with secondary diffuse meningeal spread. (WHO) + termDef: + term: >- + Meningeal Melanomatosis + source: NCIt + cde_id: C6891 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6891" + term_id: C6891 + term_version: 20.05a + +meningeal_sarcoma: + common: + description: >- + A rare sarcoma arising from the meninges. + termDef: + term: >- + Meningeal Sarcoma + source: NCIt + cde_id: C4073 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4073" + term_id: C4073 + term_version: 20.05a + +meningeal_sarcomatosis: + common: + description: >- + A rare condition characterized by diffuse spread of sarcoma cells throughout + the meninges. The neoplastic cells are derived from meningeal connective tissue. + Clinically, this disorder may present as a fulminant pachymeningitis and/or + encephalitis. + termDef: + term: >- + Meningeal Sarcomatosis + source: NCIt + cde_id: C4334 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4334" + term_id: C4334 + term_version: 20.05a + +meninges_nos: + common: + description: >- + Any one of three membranes that surround the brain and spinal cord. + termDef: + term: >- + Meninges + source: NCIt + cde_id: C12348 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12348" + term_id: C12348 + term_version: 20.05a + +meningioma_anaplastic: + common: + description: >- + A WHO grade III meningioma characterized by the presence of malignant morphologic + features, including malignant cytology and a very high mitotic index (20 or + more mitoses per ten high power fields). + termDef: + term: >- + Anaplastic (Malignant) Meningioma + source: NCIt + cde_id: C4051 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4051" + term_id: C4051 + term_version: 20.05a + +meningioma_malignant: + common: + description: >- + A WHO grade III meningioma characterized by the presence of malignant morphologic + features, including malignant cytology and a very high mitotic index (20 or + more mitoses per ten high power fields). + termDef: + term: >- + Anaplastic (Malignant) Meningioma + source: NCIt + cde_id: C4051 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4051" + term_id: C4051 + term_version: 20.05a + +meningioma_nos: + common: + description: >- + A generally slow growing tumor attached to the dura mater. It is composed of + neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, + often women and it has a wide range of histopathological appearances. Of the + various subtypes, meningothelial, fibrous and transitional meningiomas are the + most common. Most meningiomas are WHO grade I tumors, and some are WHO grade + II or III tumors. Most subtypes share a common clinical behavior, although some + subtypes are more likely to recur and follow a more aggressive clinical course. + (Adapted from WHO) + termDef: + term: >- + Meningioma + source: NCIt + cde_id: C3230 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3230" + term_id: C3230 + term_version: 20.05a + +meningiomatosis_nos: + common: + description: >- + The presence of multiple meningiomas in the leptomeninges. + termDef: + term: >- + Meningiomatosis + source: NCIt + cde_id: C3707 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3707" + term_id: C3707 + term_version: 20.05a + +meningothelial_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of tumor cells that form + lobules. The tumor cells are generally uniform. Whorls and psammoma bodies are + usually not present. + termDef: + term: >- + Meningothelial Meningioma + source: NCIt + cde_id: C4329 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4329" + term_id: C4329 + term_version: 20.05a + +meningothelial_sarcoma: + common: + description: >- + A rare sarcoma arising from the meninges. + termDef: + term: >- + Meningeal Sarcoma + source: NCIt + cde_id: C4073 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4073" + term_id: C4073 + term_version: 20.05a + +meninmll_interaction_inhibitor_sndx5613: + common: + description: >- + An orally bioavailable protein-protein interaction (PPI) inhibitor of the menin-mixed + lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) proteins, with potential + antineoplastic activity. Upon oral administration, menin-MLL interaction inhibitor + SNDX-5613 targets and binds to the nuclear protein menin, thereby preventing + the interaction between the two proteins menin and MLL and the formation of + the menin-MLL complex. This reduces the expression of downstream target genes + and results in an inhibition of the proliferation of MLL-rearranged leukemic + cells. The menin-MLL complex plays a key role in the survival, growth, transformation + and proliferation of certain kinds of leukemia cells. + termDef: + term: >- + Menin-MLL Interaction Inhibitor SNDX-5613 + source: NCIt + cde_id: C165776 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165776" + term_id: C165776 + term_version: 20.10d + +merkel_cell_carcinoma: + common: + description: >- + A rare malignant cutaneous tumor seen in elderly patients. Its usual location + is on the head, neck and extremities. The tumor is composed of small round cells + with scanty cytoplasm arranged in a trabecular pattern, or in ill-defined nodules + or in a diffuse pattern. The tumor cells contain cytoplasmic membrane-bound + dense core granules resembling neurosecretory granules. There is strong evidence + implicating Merkel cell polyomavirus in a majority of cases of Merkel cell carcinoma. + termDef: + term: >- + Merkel Cell Carcinoma + source: NCIt + cde_id: C9231 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9231" + term_id: C9231 + term_version: 20.05a + +merkel_cell_tumor: + common: + description: >- + A rare malignant cutaneous tumor seen in elderly patients. Its usual location + is on the head, neck and extremities. The tumor is composed of small round cells + with scanty cytoplasm arranged in a trabecular pattern, or in ill-defined nodules + or in a diffuse pattern. The tumor cells contain cytoplasmic membrane-bound + dense core granules resembling neurosecretory granules. There is strong evidence + implicating Merkel cell polyomavirus in a majority of cases of Merkel cell carcinoma. + termDef: + term: >- + Merkel Cell Carcinoma + source: NCIt + cde_id: C9231 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9231" + term_id: C9231 + term_version: 20.05a + +mesenchymal_chondrosarcoma: + common: + description: >- + A morphologic variant of chondrosarcoma arising from bone and soft tissue. It + is characterized by the presence of malignant small round cells, biphasic growth + pattern, and well differentiated hyaline cartilage. Clinical presentation includes + pain and swelling. The clinical course is aggressive, with local recurrences + and distant metastases. + termDef: + term: >- + Mesenchymal Chondrosarcoma + source: NCIt + cde_id: C3737 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3737" + term_id: C3737 + term_version: 20.05a + +mesenchymal_tumor_malignant: + common: + description: >- + A usually aggressive malignant neoplasm of the soft tissue or bone. It arises + from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas + occur in both children and adults. The prognosis depends largely on the degree + of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, + leiomyosarcoma, osteosarcoma, and chondrosarcoma. + termDef: + term: >- + Sarcoma + source: NCIt + cde_id: C9118 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9118" + term_id: C9118 + term_version: 20.05a + +mesenchymoma_benign: + common: + description: >- + A term describing a benign soft tissue tumor which consists of two or more mesenchymal + lines of differentiation, excluding a fibroblastic line of differentiation. + termDef: + term: >- + Benign Mesenchymoma + source: NCIt + cde_id: C4267 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4267" + term_id: C4267 + term_version: 20.05a + +mesenchymoma_malignant: + common: + description: >- + A term describing a malignant soft tissue tumor which consists of two or more + mesenchymal lines of differentiation, excluding a fibroblastic line of differentiation. + termDef: + term: >- + Malignant Mesenchymoma + source: NCIt + cde_id: C4268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4268" + term_id: C4268 + term_version: 20.05a + +mesenchymoma_nos: + common: + description: >- + A term describing a soft tissue tumor which consists of two or more mesenchymal + lines of differentiation, excluding a fibroblastic line of differentiation. + termDef: + term: >- + Mesenchymoma + source: NCIt + cde_id: C3233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3233" + term_id: C3233 + term_version: 20.05a + +mesenteric: + common: + description: >- + A lymph node located in the mesentery. + termDef: + term: >- + Mesenteric Lymph Node + source: NCIt + cde_id: C77641 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77641" + term_id: C77641 + term_version: 20.10d + +mesenteric_fibromatosis: + common: + description: >- + An insidious poorly circumscribed neoplasm arising from the deep soft tissues + of the abdomen. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + termDef: + term: >- + Abdominal (Mesenteric) Fibromatosis + source: NCIt + cde_id: C3741 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3741" + term_id: C3741 + term_version: 20.05a + +mesoblastic_nephroma: + common: + description: >- + A low grade childhood congenital malignant neoplasm arising from the kidney. + It is characterized by the presence of fibroblastic cells. The majority of cases + occur in the first year of life. Complete excision is usually associated with + an excellent prognosis. + termDef: + term: >- + Congenital Mesoblastic Nephroma + source: NCIt + cde_id: C6569 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6569" + term_id: C6569 + term_version: 20.05a + +mesodermal_mixed_tumor: + common: + description: >- + A group of tumors affecting the female reproductive system, characterized by + the presence of epithelial and stromal elements. It includes the following clinicopathological + entities: adenofibroma, adenomyoma, Mullerian adenosarcoma, and malignant mixed + mesodermal (Mullerian) tumor. + termDef: + term: >- + Mixed Mesodermal (Mullerian) Tumor + source: NCIt + cde_id: C3730 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3730" + term_id: C3730 + term_version: 20.05a + +mesonephric_adenocarcinoma: + common: + description: >- + An adenocarcinoma of the cervix or the vagina arising from mesonephric remnants. + termDef: + term: >- + Mesonephric Adenocarcinoma + source: NCIt + cde_id: C4072 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4072" + term_id: C4072 + term_version: 20.05a + +mesonephric_adenoma: + common: + description: >- + A benign epithelial neoplasm of the female reproductive system arising from + mesonephric remnants. + termDef: + term: >- + Benign Mesonephroma + source: NCIt + cde_id: C4294 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4294" + term_id: C4294 + term_version: 20.05a + +mesonephric_tumor_nos: + common: + description: >- + An epithelial neoplasm of the female reproductive system arising from mesonephric + remnants. + termDef: + term: >- + Mesonephric Neoplasm + source: NCIt + cde_id: C4295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4295" + term_id: C4295 + term_version: 20.05a + +mesonephroma_benign: + common: + description: >- + A benign epithelial neoplasm of the female reproductive system arising from + mesonephric remnants. + termDef: + term: >- + Benign Mesonephroma + source: NCIt + cde_id: C4294 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4294" + term_id: C4294 + term_version: 20.05a + +mesonephroma_malignant: + common: + description: >- + An adenocarcinoma of the cervix or the vagina arising from mesonephric remnants. + termDef: + term: >- + Mesonephric Adenocarcinoma + source: NCIt + cde_id: C4072 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4072" + term_id: C4072 + term_version: 20.05a + +mesonephroma_nos: + common: + description: >- + An epithelial neoplasm of the female reproductive system arising from mesonephric + remnants. + termDef: + term: >- + Mesonephric Neoplasm + source: NCIt + cde_id: C4295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4295" + term_id: C4295 + term_version: 20.05a + +mesothelin: + common: + description: >- + Mesothelin (630 aa, ~69 kDa) is encoded by the human MSLN gene. This protein + may play a role in cellular adhesion. + termDef: + term: >- + Mesothelin + source: NCIt + cde_id: C20887 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20887" + term_id: C20887 + term_version: 20.10d + +mesothelioma: + common: + description: >- + A usually malignant and aggressive neoplasm of the mesothelium which is often + associated with exposure to asbestos. + termDef: + term: >- + Mesothelioma + source: NCIt + cde_id: C3234 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3234" + term_id: C3234 + term_version: 19.12e + +mesothelioma_benign: + common: + description: >- + A benign neoplasm arising from mesothelial cells. It is characterized by the + formation of glandular and tubular patterns. It can occur in several anatomic + sites including the pleura, peritoneum, and epididymis. + termDef: + term: >- + Adenomatoid Tumor + source: NCIt + cde_id: C3762 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3762" + term_id: C3762 + term_version: 20.05a + +mesothelioma_biphasic_malignant: + common: + description: >- + A malignant mesothelioma characterized by the presence of epithelioid and sarcomatoid + components, with each component representing at least 10% of the tumor. + termDef: + term: >- + Biphasic Mesothelioma + source: NCIt + cde_id: C4282 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4282" + term_id: C4282 + term_version: 20.05a + +mesothelioma_biphasic_nos: + common: + description: >- + A malignant mesothelioma characterized by the presence of epithelioid and sarcomatoid + components, with each component representing at least 10% of the tumor. + termDef: + term: >- + Biphasic Mesothelioma + source: NCIt + cde_id: C4282 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4282" + term_id: C4282 + term_version: 20.05a + +mesothelioma_malignant: + common: + description: >- + A malignant neoplasm that arises from mesothelial cells. It is associated with + exposure to asbestos. + termDef: + term: >- + Malignant Mesothelioma + source: NCIt + cde_id: C4456 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4456" + term_id: C4456 + term_version: 20.05a + +mesothelioma_nos: + common: + description: >- + A usually malignant and aggressive neoplasm of the mesothelium which is often + associated with exposure to asbestos. + termDef: + term: >- + Mesothelioma + source: NCIt + cde_id: C3234 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3234" + term_id: C3234 + term_version: 20.05a + +met: + common: + description: >- + This gene plays a regulatory role in the modulation of cell-surface receptors + and hepatocyte growth factor interactions. + termDef: + term: >- + MET Gene + source: NCIt + cde_id: C18325 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18325" + term_id: C18325 + term_version: 20.10d + +met_x_met_bispecific_antibody_regn5093: + common: + description: >- + A bispecific monoclonal antibody that targets two different epitopes of the + human tumor-associated antigen (TAA) MET (c-MET; hepatocyte growth factor receptor; + HGFR), with potential antineoplastic activity. Upon administration, MET x MET + bispecific antibody REGN5093 targets and binds to two different, non-overlapping + epitopes on MET expressed on the tumor cell surface, thereby forming unique + REGN5093-MET complexes. The binding of REGN5093 to the MET epitopes and the + unique complex formation causes MET internalization and degradation. This prevents + MET-mediated signaling and inhibits growth of MET-driven tumor cells. MET, a + receptor tyrosine kinase, is overexpressed on the cell surfaces of various solid + tumor cell types where it is involved in epithelial-mesenchymal transition; + it plays a key role in cancer cell growth, survival, angiogenesis, invasion, + and metastasis. + termDef: + term: >- + MET x MET Bispecific Antibody REGN5093 + source: NCIt + cde_id: C167188 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167188" + term_id: C167188 + term_version: 20.10d + +metamyelocytes: + common: + description: >- + The determination of the number of metamyelocytes present in a sample. + termDef: + term: >- + Metamyelocyte Count + source: NCIt + cde_id: C74615 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74615" + term_id: C74615 + term_version: 20.10d + +metanephric_adenoma: + common: + description: >- + A benign, well-circumscribed renal cortical neoplasm affecting females more + often than males. Polycythemia has been reported in twelve-percent of patients. + termDef: + term: >- + Metanephric Adenoma + source: NCIt + cde_id: C27253 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27253" + term_id: C27253 + term_version: 20.05a + +metaplastic_carcinoma_nos: + common: + description: >- + A general term used to describe carcinomas arising from epithelial cells that + have been transformed into another cells type (metaplastic epithelial cells). + A representative example is the adenocarcinoma arising in Barrett esophagus. + This term is also used to describe carcinomas in which the malignant epithelial + cells show differentiation towards another cell type. A representative example + of the latter is the metaplastic breast carcinoma in which the malignant glandular + cells show squamous, spindle cell, or chondroid/osseous differentiation. + termDef: + term: >- + Metaplastic Carcinoma + source: NCIt + cde_id: C27949 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27949" + term_id: C27949 + term_version: 20.05a + +metaplastic_carcinoma_of_no_special_type: + common: + description: >- + A general term used to describe carcinomas arising from epithelial cells that + have been transformed into another cells type (metaplastic epithelial cells). + A representative example is the adenocarcinoma arising in Barrett esophagus. + This term is also used to describe carcinomas in which the malignant epithelial + cells show differentiation towards another cell type. A representative example + of the latter is the metaplastic breast carcinoma in which the malignant glandular + cells show squamous, spindle cell, or chondroid/osseous differentiation. + termDef: + term: >- + Metaplastic Carcinoma + source: NCIt + cde_id: C27949 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27949" + term_id: C27949 + term_version: 20.05a + +metaplastic_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of a prominent mesenchymal + component. The mesenchymal component may be osseous, cartilaginous, myxoid, + lipomatous, or a mixture of mesenchymal elements. + termDef: + term: >- + Metaplastic Meningioma + source: NCIt + cde_id: C6907 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6907" + term_id: C6907 + term_version: 20.05a + +metarrestin: + common: + description: >- + An orally available small molecule inhibitor of perinucleolar compartment (PNC), + with potential antineoplastic activities. Although the exact mechanisms(s) through + which this agent exerts its effects have yet to be fully elucidated, upon oral + administration, metarrestin disrupts the structure of PNC and inhibits RNA polymerase + (Pol) I transcription. This leads to the reduction in the prevalence of PNC + in cancer cells and decrease in tumor growth and spread. PNC is a subnuclear + structure and a phenotypic marker of metastatic cancer cells. A high PNC prevalence + has been associated with disease progression and poor patient outcomes. + termDef: + term: >- + Metarrestin + source: NCIt + cde_id: C168544 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168544" + term_id: C168544 + term_version: 20.10d + +metastasis: + common: + description: >- + A tumor that has spread from its original (primary) site of growth to another + site, close to or distant from the primary site. Metastasis is characteristic + of advanced malignancies, but in rare instances can be seen in neoplasms lacking + malignant morphology. + termDef: + term: >- + Metastatic Neoplasm + source: NCIt + cde_id: C3261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3261" + term_id: C3261 + term_version: 20.05a + +metastasis_nos: + common: + description: >- + The spread or migration of cancer cells from one part of the body (the organ + in which it first appeared) to another. The secondary tumor contains cells that + are like those in the original (primary) tumor. + termDef: + term: >- + Metastasis + source: NCIt + cde_id: C19151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19151" + term_id: C19151 + term_version: 20.05a + +metastatic_signet_ring_cell_carcinoma: + common: + description: >- + A signet ring cell carcinoma that has spread from its original site of growth + to another anatomic site. + termDef: + term: >- + Metastatic Signet Ring Cell Carcinoma + source: NCIt + cde_id: C66717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66717" + term_id: C66717 + term_version: 20.05a + +metatypical_carcinoma: + common: + description: >- + A skin carcinoma displaying cytological characteristics intermediate to nodular + basal cell carcinoma and squamous cell carcinoma. + termDef: + term: >- + Skin Metatypical Carcinoma + source: NCIt + cde_id: C66903 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66903" + term_id: C66903 + term_version: 20.05a + +methylation: + common: + description: >- + The covalent chemical or biochemical addition of a methyl group(s) to a compound. + (NCI) + termDef: + term: >- + Methylation + source: NCIt + cde_id: C16848 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16848" + term_id: C16848 + term_version: 20.10d + +methylcantharidimide: + common: + description: >- + An orally bioavailable derivative of the terpenoid cantharidin, which is a natural + toxin extracted from blister beetles, with potential antineoplastic activity. + Although the exact mechanism of action through which methylcantharidimide exerts + its effect has yet to be fully elucidated, this agent, upon oral administration, + may exert a direct tumor cell killing effect in susceptible tumor cells. + termDef: + term: >- + Methylcantharidimide + source: NCIt + cde_id: C173446 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173446" + term_id: C173446 + term_version: 20.10d + +mevociclib: + common: + description: >- + A selective inhibitor of cyclin-dependent kinase 7 (CDK7), with potential antineoplastic + activity. Upon administration, SY-1365 binds to and inhibits CDK7, thereby inhibiting + CDK7-mediated signal transduction pathways. This inhibits cell growth of CDK7-overexpressing + tumor cells. CDK7, a serine/threonine kinase, plays a key role in cell proliferation; + CDK7 is overexpressed in a variety of tumor cell types. + termDef: + term: >- + Mevociclib + source: NCIt + cde_id: C139552 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139552" + term_id: C139552 + term_version: 20.10d + +mexico: + common: + description: >- + A country in southern North America, bordering the North Pacific Ocean and the + Gulf of Mexico, south of the US. + termDef: + term: >- + Mexico + source: NCIt + cde_id: C16850 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16850" + term_id: C16850 + term_version: 19.12e + +mezagitamab: + common: + description: >- + A human, non-agonistic immunoglobulin G1 (IgG1) monoclonal antibody directed + against the cell surface glycoprotein ADP-ribosyl cyclase 1 (CD38) with potential + immunomodulating and antineoplastic activities. Mezagitamab specifically binds + to CD38 that is expressed on human plasmablasts, plasma cells, NK cells and + activated T- and B-cells. This may trigger antibody-dependent cellular cytotoxicity + (ADCC), cell lysis and depletion of CD38-expressing cells. Additionally, TAK-079 + does not induce CD38-dependent signaling and does not promote cytokine activation + in peripheral blood mononuclear cells (PMBCs). CD38, a type II transmembrane + glycoprotein, is overexpressed on cells associated with autoimmune diseases + and hematologic malignancies. + termDef: + term: >- + Mezagitamab + source: NCIt + cde_id: C148078 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148078" + term_id: C148078 + term_version: 20.10d + +mg: + common: + description: >- + A metric unit of mass equal to one thousandth of a gram or 1000 micrograms. + One milligram equals approximately 0.015 432 grain or 35.274 x 10E-6 ounce. + termDef: + term: >- + Milligram + source: NCIt + cde_id: C28253 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28253" + term_id: C28253 + term_version: 20.10d + +mgmt: + common: + description: >- + This gene is involved in DNA repair. + termDef: + term: >- + MGMT Gene + source: NCIt + cde_id: C21232 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21232" + term_id: C21232 + term_version: 20.10d + +mgus: + common: + description: >- + A condition in which an abnormal amount of a single immunoglobulin is present + in the serum. This category includes IgM monoclonal gammopathy of undetermined + significance and non-IgM monoclonal gammopathy of undetermined significance. + Up to 25% of cases of monoclonal gammopathy of undetermined significance progress + to a B-cell malignancy or myeloma. + termDef: + term: >- + Monoclonal Gammopathy of Undetermined Significance + source: NCIt + cde_id: C3996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3996" + term_id: C3996 + term_version: 20.05a + +mh2a: + common: + description: >- + A histone protein that is comprised of a histone H2A domain, which allows interaction + with the nucleosome, and a macro domain, which may bind to ADP-ribose. This + protein can substitute for histone H2A in the nucleosomal complex and plays + a role in transcriptional repression and X chromosome inactivation. + termDef: + term: >- + Core Histone Macro-H2A + source: NCIt + cde_id: C95407 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95407" + term_id: C95407 + term_version: 20.10d + +mh2a1: + common: + description: >- + Core histone macro-H2A.1 (372 aa, ~40 kDa) is encoded by the human MACROH2A1 + gene. This protein plays a role in chromatin modification. + termDef: + term: >- + Core Histone Macro-H2A.1 + source: NCIt + cde_id: C113624 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113624" + term_id: C113624 + term_version: 20.10d + +mh2a2: + common: + description: >- + Core histone macro-H2A.2 (372 aa, ~40 kDa) is encoded by the human MACROH2A2 + gene. This protein plays a role in nucleosome formation and transcriptional + repression. + termDef: + term: >- + Core Histone Macro-H2A.2 + source: NCIt + cde_id: C154659 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154659" + term_id: C154659 + term_version: 20.10d + +mib1: + common: + description: >- + This gene is involved in both ubiquitination and cell signaling. + termDef: + term: >- + MIB1 Gene + source: NCIt + cde_id: C104651 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104651" + term_id: C104651 + term_version: 20.10d + +micro: + common: + description: >- + Too small to be seen except under a microscope. + termDef: + term: >- + Microscopic + source: NCIt + cde_id: C25252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25252" + term_id: C25252 + term_version: 20.05a + +microarray: + common: + description: >- + Analysis using microarray technology (e.g., cDNA arrays to see gene expression + or protein microarrays to profile the pattern of proteins). + termDef: + term: >- + Microarray Analysis + source: NCIt + cde_id: C18477 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18477" + term_id: C18477 + term_version: 20.10d + +microbiome_gen001: + common: + description: >- + A microbiome therapeutic composed of a single-strain bacterium, isolated from + the gut of healthy donors, with potential anti-tumor and immunomodulating activities. + Upon oral administration, the metabolites of GEN-001 may activate dendritic + cells and macrophages in the gut and increase the expression of the cytokines + interleukin-7 (IL-7) and interleukin-15 (IL-15), which stimulates the proliferation + of natural killer (NK) cells and memory CD8+ T-cells. The memory T-cells enhance + the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates + the immune response against tumor cells. This may increase tumor cell killing + and decrease tumor cell proliferation. GEN-001 may improve therapeutic responses + to other therapies, such as anti-PD-1 therapy. + termDef: + term: >- + Microbiome GEN-001 + source: NCIt + cde_id: C171422 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171422" + term_id: C171422 + term_version: 20.10d + +microbiomederived_peptide_vaccine_eo2401: + common: + description: >- + A donor-derived, off-the-shelf, microbiome therapeutic cancer peptide vaccine + composed of three bacterial onco-mimics, immunogenic microbiome-derived peptides + that are highly homologous to tumor-associated antigens (TAAs), that are obtained + and selected from the human gut microbiome and are specific for brain tumors, + including glioblastoma, with potential immunomodulating and antineoplastic activities. + The three microbiome-derived bacterial antigens in EO2401 mimic three TAAs that + are highly expressed by brain tumors. Upon administration of microbiome-derived + peptide vaccine EO2401, the peptides are taken up by and presented on dendritic + cells (DCs) to T-cells. As the presented antigens display molecular mimicry + with selected TAAs on brain cancer cells, a memory T-cell and cytotoxic T-lymphocyte + (CTL)-mediated immune response may be mounted against the TAAs expressed on + the brain cancer cells, thereby eradicating the brain cancer cells. + termDef: + term: >- + Microbiome-derived Peptide Vaccine EO2401 + source: NCIt + cde_id: C165646 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165646" + term_id: C165646 + term_version: 20.10d + +microcystic_adenoma: + common: + description: >- + A benign epithelial neoplasm characterized by a microcystic pattern. The cystic + spaces are lined by small cuboidal cells without evidence of significant cytologic + atypia. + termDef: + term: >- + Microcystic Adenoma + source: NCIt + cde_id: C3685 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3685" + term_id: C3685 + term_version: 20.05a + +microcystic_adnexal_carcinoma: + common: + description: >- + A low grade adenocarcinoma with ductal differentiation, arising from the sweat + glands. It presents as a scar usually in the face. It is characterized by the + formation of small ducts and it frequently involves nerves and perineural spaces. + termDef: + term: >- + Microcystic Adnexal Carcinoma + source: NCIt + cde_id: C7581 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7581" + term_id: C7581 + term_version: 20.05a + +microcystic_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of intercellular microcystic + spaces that contain mucinous fluid. + termDef: + term: >- + Microcystic Meningioma + source: NCIt + cde_id: C4721 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4721" + term_id: C4721 + term_version: 20.05a + +microcystic_urothelial_carcinoma: + common: + description: >- + A variant of infiltrating bladder urothelial carcinoma. It is characterized + by microcysts formation. It is also associated with intracytoplasmic mucin deposits + and calcification in cyst walls. + termDef: + term: >- + Infiltrating Bladder Urothelial Carcinoma, Microcystic Variant + source: NCIt + cde_id: C39820 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39820" + term_id: C39820 + term_version: 20.05a + +microfollicular_adenoma_nos: + common: + description: >- + A thyroid gland adenoma composed of microfollicular structures. + termDef: + term: >- + Thyroid Gland Microfollicular Adenoma + source: NCIt + cde_id: C4160 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4160" + term_id: C4160 + term_version: 20.05a + +microglioma: + common: + description: >- + A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as + a primary lesion. There is no evidence of lymphoma outside the central nervous + system at the time of diagnosis. + termDef: + term: >- + Central Nervous System Lymphoma + source: NCIt + cde_id: C9301 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9301" + term_id: C9301 + term_version: 20.05a + +micropapillary: + common: + description: >- + A morphologic finding indicating the presence of an architectural pattern dominated + by the presence of small papillary structures. + termDef: + term: >- + Micropapillary Pattern + source: NCIt + cde_id: C36181 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36181" + term_id: C36181 + term_version: 20.10d + +micropapillary_serous_carcinoma: + common: + description: >- + An adenocarcinoma usually arising from the ovary. It is characterized by the + presence of complex micropapillary structures covered by round and cuboidal + cells with a high nuclear to cytoplasmic ratio. + termDef: + term: >- + Micropapillary Serous Carcinoma + source: NCIt + cde_id: C6882 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6882" + term_id: C6882 + term_version: 20.05a + +microsatellite_analysis: + common: + description: >- + A laboratory procedure to detect microsatellite instability. + termDef: + term: >- + Microsatellite Instability Analysis + source: NCIt + cde_id: C63331 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63331" + term_id: C63331 + term_version: 20.10d + +microscopic: + common: + description: >- + Too small to be seen except under a microscope. + termDef: + term: >- + Microscopic + source: NCIt + cde_id: C25252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25252" + term_id: C25252 + term_version: 20.05a + +middle_ear: + common: + description: >- + The part of the ear including the eardrum and ossicles. The middle ear leads + to the inner ear. + termDef: + term: >- + Middle Ear + source: NCIt + cde_id: C12274 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12274" + term_id: C12274 + term_version: 20.05a + +middle_lobe_lung: + common: + description: >- + The smallest lobe of the right lung, situated above the oblique fissure and + below the horizontal fissure. + termDef: + term: >- + Middle Lobe of the Right Lung + source: NCIt + cde_id: C12286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12286" + term_id: C12286 + term_version: 20.05a + +middle_third_of_esophagus: + common: + description: >- + The middle one third of the esophagus in which the muscle layer is composed + of muscle cells of the striated and smooth types. + termDef: + term: >- + Middle Third of the Esophagus + source: NCIt + cde_id: C12254 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12254" + term_id: C12254 + term_version: 20.05a + +midline: + common: + description: >- + A medial line, especially the medial line or medial plane of the body (or some + part of the body). + termDef: + term: >- + Midline + source: NCIt + cde_id: C81170 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81170" + term_id: C81170 + term_version: 20.05a + +midline_carcinoma_of_children_and_young_adults_with_nut_rearrangement: + common: + description: >- + A rare, highly aggressive and lethal carcinoma that affects children and young + adults. It arises from midline epithelial structures, most commonly the head, + neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized + by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) + is present that results in the creation of a fusion gene involving the NUT gene, + most commonly BRD4-NUT fusion gene. + termDef: + term: >- + NUT Carcinoma + source: NCIt + cde_id: C45716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45716" + term_id: C45716 + term_version: 20.05a + +milataxel: + common: + description: >- + An orally bioavailable taxane with potential antineoplastic activity. Upon oral + administration, milataxel and its major active metabolite M-10 bind to and stabilize + tubulin, resulting in the inhibition of microtubule depolymerization and cell + division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell + proliferation. Unlike other taxane compounds, milataxel appears to be a poor + substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein + (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. + termDef: + term: >- + Milataxel + source: NCIt + cde_id: C77880 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77880" + term_id: C77880 + term_version: 20.10d + +mild: + common: + description: >- + Gentle or temperate in nature or degree. + termDef: + term: >- + Mild + source: NCIt + cde_id: C70666 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70666" + term_id: C70666 + term_version: 20.10d + +minimally_invasive_adenocarcinoma_mucinous: + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by tall columnar cells and mucin production. + termDef: + term: >- + Minimally Invasive Lung Mucinous Adenocarcinoma + source: NCIt + cde_id: C7268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7268" + term_id: C7268 + term_version: 20.05a + +minimally_invasive_adenocarcinoma_nonmucinous: + common: + description: >- + A morphologic variant of minimally invasive lung adenocarcinoma characterized + by the presence of Clara cells and/or type II cells. + termDef: + term: >- + Minimally Invasive Lung Non-Mucinous Adenocarcinoma + source: NCIt + cde_id: C7269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7269" + term_id: C7269 + term_version: 20.05a + +minimally_invasive_adenocarcinoma_nos: + common: + description: >- + A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is + characterized by a predominantly lepidic pattern and 5 mm or less invasion in + greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely + may be mucinous. + termDef: + term: >- + Minimally Invasive Lung Adenocarcinoma + source: NCIt + cde_id: C2923 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2923" + term_id: C2923 + term_version: 20.05a + +miptenalimab: + common: + description: >- + A monoclonal antibody directed against the inhibitory receptor lymphocyte activation + gene 3 protein (LAG3; LAG-3), with potential immune checkpoint inhibitory and + antineoplastic activities. Upon administration,miptenalimab binds to LAG3 expressed + on tumor-infiltrating lymphocytes (TILs) and blocks its binding with major histocompatibility + complex (MHC) class II molecules expressed on tumor cells. This activates antigen-specific + T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which + leads to a reduction in tumor growth. LAG3, a member of the immunoglobulin superfamily + (IgSF), is expressed on various immune cells, and negatively regulates both + proliferation and activation of T-cells. Its expression on TILs is associated + with tumor-mediated immune suppression. + termDef: + term: >- + Miptenalimab + source: NCIt + cde_id: C150403 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150403" + term_id: C150403 + term_version: 20.10d + +miransertib: + common: + description: >- + An orally bioavailable inhibitor of the serine/threonine protein kinase AKT + (protein kinase B) with potential antineoplastic activity. Miransertib binds + to and inhibits the activity of AKT in a non-ATP competitive manner, which may + result in the inhibition of the PI3K/AKT signaling pathway. This may lead to + the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. + The AKT signaling pathway is often deregulated in cancer and is associated with + tumor cell proliferation, survival and migration. + termDef: + term: >- + Miransertib + source: NCIt + cde_id: C99172 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99172" + term_id: C99172 + term_version: 20.10d + +mirdametinib: + common: + description: >- + An orally bioavailable, synthetic organic molecule targeting mitogen-activated + protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic + activity. Upon administration, mirdametinib selectively binds to and inhibits + MEK, which may result in the inhibition of the phosphorylation and activation + of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific + threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling + pathway that is frequently activated in human tumors. + termDef: + term: >- + Mirdametinib + source: NCIt + cde_id: C52195 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C52195" + term_id: C52195 + term_version: 20.10d + +mirna: + common: + description: >- + A sequence of single-stranded RNA, that is 20-25 nucleotides in length, which + is transcribed from DNA but is not translated into a protein. This nucleic acid + may regulate the transcription or translation of other genes. + termDef: + term: >- + MicroRNA + source: NCIt + cde_id: C25966 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25966" + term_id: C25966 + term_version: 20.10d + +mirzotamab_clezutoclax: + common: + description: >- + An antibody-drug conjugate (ADC) composed of an as of yet undisclosed monoclonal + antibody against a tumor-associated antigen (TAA) linked to an as of yet undisclosed + cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration + of mirzotamab clezutoclax, the monoclonal antibody moiety of ABBV-155 targets + and binds to the TAA expressed on tumor cells. Upon binding and internalization, + the cytotoxic agent is released and kills the TAA-expressing cancer cells, through + an as of yet unknown mechanism of action. + termDef: + term: >- + Mirzotamab Clezutoclax + source: NCIt + cde_id: C157279 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157279" + term_id: C157279 + term_version: 20.10d + +missense_variant: + common: + description: >- + A point mutation occurring within the protein-coding region of a gene, and which + codes for a different amino acid than expected. + termDef: + term: >- + Missense Mutation + source: NCIt + cde_id: C18133 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18133" + term_id: C18133 + term_version: 20.10d + +mit_family_translocation_renal_cell_carcinoma: + common: + description: >- + A renal cell carcinoma (RCC) usually seen in children or young adults. It is + characterized by papillary, alveolar and nested growth patterns with clear and + eosinophilic cells. The carcinomas range from microscopic lesions to clinically + symptomatic tumors. It is associated with translocations/gene fusions involving + members of the MiT family of transcription factors, including TFE3 and TFEB. + There are two subtypes; RCCs associated with Xp11 translocations and TFE3 gene + fusions and RCCs with t(6:11) translocations resulting in MALAT1-TFEB gene fusions. + termDef: + term: >- + MiT Family Translocation-Associated Renal Cell Carcinoma + source: NCIt + cde_id: C154494 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154494" + term_id: C154494 + term_version: 20.05a + +mitazalimab: + common: + description: >- + A human immunoglobulin (Ig) G1 monoclonal antibody directed against the cell + surface receptor CD40 with potential immunostimulatory and antineoplastic activities. + Upon intratumoral administration, mitazalimab binds to CD40 on antigen-presenting + dendritic cells, which leads to the activation and proliferation of effector + and memory T-cells, and enhances the immune response against tumor cells. In + addition, this agent binds to the CD40 antigen present on the surfaces of tumor + cells, which induces antibody-dependent cytotoxicity (ADCC). This eventually + inhibits the proliferation of CD40-expressing tumor cells. CD40, a stimulatory + receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, + is expressed on various immune cells, such as macrophages, dendritic cells and + various tumor cell types; it plays a key role in the activation of the immune + system. + termDef: + term: >- + Mitazalimab + source: NCIt + cde_id: C121538 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121538" + term_id: C121538 + term_version: 20.10d + +mitf: + common: + description: >- + This gene is involved in transcriptional promotion in melanocytes. + termDef: + term: >- + MITF Gene + source: NCIt + cde_id: C70584 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70584" + term_id: C70584 + term_version: 20.10d + +mixed_acidophilbasophil_adenoma: + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells stain positive with acidic and basic dyes. + termDef: + term: >- + Pituitary Gland Mixed Acidophil-Basophil Adenoma + source: NCIt + cde_id: C4148 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4148" + term_id: C4148 + term_version: 20.05a + +mixed_acidophilbasophil_carcinoma: + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with acidic and basic dyes. + termDef: + term: >- + Pituitary Gland Mixed Acidophil-Basophil Carcinoma + source: NCIt + cde_id: C4149 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4149" + term_id: C4149 + term_version: 20.05a + +mixed_acinarendocrineductal_carcinoma: + common: + description: >- + A carcinoma that arises from the pancreas showing either extensive mucin accumulation + and acinar neoplastic cells or a mixture of columnar or signet-ring cells and + acinar neoplastic cells. + termDef: + term: >- + Mixed Acinar-Ductal Carcinoma of the Pancreas + source: NCIt + cde_id: C95458 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95458" + term_id: C95458 + term_version: 20.05a + +mixed_adenocarcinoma_and_epidermoid_carcinoma: + common: + description: >- + An invasive carcinoma composed of malignant glandular cells and malignant squamous + cells. + termDef: + term: >- + Adenosquamous Carcinoma + source: NCIt + cde_id: C3727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3727" + term_id: C3727 + term_version: 20.05a + +mixed_adenocarcinoma_and_squamous_cell_carcinoma: + common: + description: >- + An invasive carcinoma composed of malignant glandular cells and malignant squamous + cells. + termDef: + term: >- + Adenosquamous Carcinoma + source: NCIt + cde_id: C3727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3727" + term_id: C3727 + term_version: 20.05a + +mixed_adenomatous_and_hyperplastic_polyp: + common: + description: >- + An adenoma that arises from the large intestine and the appendix. It is characterized + by prominent serration of the glands and the presence of generalized low-grade + dysplasia. + termDef: + term: >- + Traditional Serrated Adenoma + source: NCIt + cde_id: C38458 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38458" + term_id: C38458 + term_version: 20.05a + +mixed_adenoneuroendocrine_carcinoma: + common: + description: >- + A carcinoma that arises from the digestive system and is characterized by the + presence of a malignant glandular epithelial component and a malignant neuroendocrine + component. At least 30% of either component should be present for the diagnosis + to be made. + termDef: + term: >- + Digestive System Mixed Adenoneuroendocrine Carcinoma + source: NCIt + cde_id: C95406 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95406" + term_id: C95406 + term_version: 20.05a + +mixed_basalsquamous_cell_carcinoma: + common: + description: >- + A basal cell carcinoma which displays squamous differentiation. The neoplastic + cells have more abundant cytoplasm with more marked keratinization than typical + basal cell carcinomas. It usually has a more aggressive clinical course compared + to typical basal cell carcinoma, and it may produce regional or widespread metastases. + termDef: + term: >- + Skin Basosquamous Cell Carcinoma + source: NCIt + cde_id: C2922 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2922" + term_id: C2922 + term_version: 20.05a + +mixed_carcinoidadenocarcinoma: + common: + description: >- + A carcinoma that arises from the digestive system and is characterized by the + presence of a malignant glandular epithelial component and a malignant neuroendocrine + component. At least 30% of either component should be present for the diagnosis + to be made. + termDef: + term: >- + Digestive System Mixed Adenoneuroendocrine Carcinoma + source: NCIt + cde_id: C95406 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95406" + term_id: C95406 + term_version: 20.05a + +mixed_cell_adenocarcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of a mixed malignant glandular + cell population. + termDef: + term: >- + Mixed Cell Adenocarcinoma + source: NCIt + cde_id: C4158 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4158" + term_id: C4158 + term_version: 20.05a + +mixed_cell_adenoma: + common: + description: >- + An adenoma characterized by the presence of a mixed epithelial cell population. + termDef: + term: >- + Mixed Cell Adenoma + source: NCIt + cde_id: C4157 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4157" + term_id: C4157 + term_version: 20.05a + +mixed_ductalendocrine_carcinoma: + common: + description: >- + A carcinoma that arises from the pancreas showing a mixture of ductal and neuroendocrine + malignant cells in both the primary tumor and in the metastatic sites. + termDef: + term: >- + Mixed Ductal-Neuroendocrine Carcinoma of the Pancreas + source: NCIt + cde_id: C6879 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6879" + term_id: C6879 + term_version: 20.05a + +mixed_embryonal_carcinoma_and_teratoma: + common: + description: >- + A germ cell tumor characterized by the presence of an embryonal carcinoma component + and a teratoma component. + termDef: + term: >- + Mixed Embryonal Carcinoma and Teratoma + source: NCIt + cde_id: C3756 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3756" + term_id: C3756 + term_version: 20.05a + +mixed_epithelioid_and_spindle_cell_melanoma: + common: + description: >- + A melanoma characterized by the presence of malignant large epithelioid melanocytes + and malignant spindle-shaped melanocytes. + termDef: + term: >- + Mixed Epithelioid and Spindle Cell Melanoma + source: NCIt + cde_id: C66756 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66756" + term_id: C66756 + term_version: 20.05a + +mixed_germ_cell_sex_cordstromal_tumor_unclassified: + common: + description: >- + A testicular mixed germ cell-sex cord-stromal tumor in which the neoplastic + germ cells and the neoplastic sex cord-stromal cells do not form nests and are + instead arranged in a diffuse pattern. + termDef: + term: >- + Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor, Unclassified + source: NCIt + cde_id: C39912 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39912" + term_id: C39912 + term_version: 20.05a + +mixed_germ_cell_tumor: + common: + description: >- + A malignant germ cell tumor characterized by the presence of at least two different + germ cell tumor components. The different germ cell tumor components include + choriocarcinoma, embryonal carcinoma, yolk sac tumor, teratoma, and seminoma. + It occurs in the ovary, testis, and extragonadal sites including central nervous + system and mediastinum. + termDef: + term: >- + Mixed Germ Cell Tumor + source: NCIt + cde_id: C4290 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4290" + term_id: C4290 + term_version: 20.05a + +mixed_glioma: + common: + description: >- + A tumor composed of two or more glial cell types (astrocytes, ependymal cells, + and oligodendrocytes). + termDef: + term: >- + Mixed Glioma + source: NCIt + cde_id: C3903 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3903" + term_id: C3903 + term_version: 20.05a + +mixed_hepatocellular_and_bile_duct_carcinoma: + common: + description: >- + A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma + that are intimately admixed. This tumor should be distinguished from separate + hepatocellular carcinoma and cholangiocarcinoma arising in the same liver. The + prognosis of this tumor is poor. + termDef: + term: >- + Combined Hepatocellular Carcinoma and Cholangiocarcinoma + source: NCIt + cde_id: C3828 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3828" + term_id: C3828 + term_version: 20.05a + +mixed_liposarcoma: + common: + description: >- + A malignant neoplasm characterized by the presence of a combination of liposarcomatous + morphologic subtypes: myxoid/round cell and well differentiated/dedifferentiated + liposarcoma or myxoid/round cell and pleomorphic liposarcoma. + termDef: + term: >- + Mixed Liposarcoma + source: NCIt + cde_id: C4253 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4253" + term_id: C4253 + term_version: 20.05a + +mixed_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the coexistence of meningothelial + cells and fibrous architectural patterns. + termDef: + term: >- + Transitional Meningioma + source: NCIt + cde_id: C4333 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4333" + term_id: C4333 + term_version: 20.05a + +mixed_mesenchymal_sarcoma: + common: + description: >- + A term describing a malignant soft tissue tumor which consists of two or more + mesenchymal lines of differentiation, excluding a fibroblastic line of differentiation. + termDef: + term: >- + Malignant Mesenchymoma + source: NCIt + cde_id: C4268 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4268" + term_id: C4268 + term_version: 20.05a + +mixed_mesenchymal_tumor: + common: + description: >- + A term describing a soft tissue tumor which consists of two or more mesenchymal + lines of differentiation, excluding a fibroblastic line of differentiation. + termDef: + term: >- + Mesenchymoma + source: NCIt + cde_id: C3233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3233" + term_id: C3233 + term_version: 20.05a + +mixed_phenotype_acute_leukemia_bmyeloid_nos: + common: + description: >- + A rare mixed phenotype acute leukemia in which the blasts express B-lymphoid + and myeloid lineage markers but are negative for MLL translocation and t(9;22)(q34;q11.2) + translocation. The prognosis is usually unfavorable. + termDef: + term: >- + Mixed Phenotype Acute Leukemia, B/Myeloid, Not Otherwise Specified + source: NCIt + cde_id: C82212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82212" + term_id: C82212 + term_version: 20.05a + +mixed_phenotype_acute_leukemia_tmyeloid_nos: + common: + description: >- + A rare mixed phenotype acute leukemia in which the blasts express T-lymphoid + and myeloid lineage markers but are negative for MLL translocation and t(9;22)(q34;q11.2) + translocation. The prognosis is usually unfavorable. + termDef: + term: >- + Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified + source: NCIt + cde_id: C82213 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82213" + term_id: C82213 + term_version: 20.05a + +mixed_phenotype_acute_leukemia_with_t922q34q112_bcrabl1: + common: + description: >- + A rare mixed phenotype acute leukemia in which the blasts also carry the translocation + t(9;22)(q34.1;q11.2) by karyotypic analysis or the BCR-ABL1 translocation by + FISH or PCR. The prognosis is usually unfavorable. + termDef: + term: >- + Mixed Phenotype Acute Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 + source: NCIt + cde_id: C82192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82192" + term_id: C82192 + term_version: 20.05a + +mixed_phenotype_acute_leukemia_with_tv11q23_mll_rearranged: + common: + description: >- + A rare mixed phenotype acute leukemia in which the blasts also carry a translocation + (v; 11q23.3) involving the KMT2A gene. The prognosis is usually unfavorable. + termDef: + term: >- + Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged + source: NCIt + cde_id: C82203 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82203" + term_id: C82203 + term_version: 20.05a + +mixed_small_cell_carcinoma: + common: + description: >- + A morphologic variant of small cell lung carcinoma in combination with a non-small + cell carcinoma. + termDef: + term: >- + Combined Lung Small Cell Carcinoma + source: NCIt + cde_id: C9137 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9137" + term_id: C9137 + term_version: 20.05a + +mixed_subependymomaependymoma: + common: + description: >- + A benign, slow growing neoplasm which is typically attached to a ventricular + wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary + matrix with frequent microcystic change. Some lesions have the histological + features of both subependymoma and ependymoma. It is often detected incidentally + and has a very favorable prognosis. (Adapted from WHO.) + termDef: + term: >- + Subependymoma + source: NCIt + cde_id: C3795 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3795" + term_id: C3795 + term_version: 20.05a + +mixed_teratoma_and_seminoma: + common: + description: >- + Mixed Teratoma and Seminoma + termDef: + term: >- + Mixed Teratoma and Seminoma + source: NCIt + cde_id: C9010 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9010" + term_id: C9010 + term_version: 20.05a + +mixed_tumor_malignant_nos: + common: + description: >- + A malignant tumor arising from the salivary gland. It includes carcinoma ex + pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing + pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of + malignant epithelial and sarcomatous elements. + termDef: + term: >- + Malignant Mixed Tumor of the Salivary Gland + source: NCIt + cde_id: C8025 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8025" + term_id: C8025 + term_version: 20.05a + +mixed_tumor_nos: + common: + description: >- + A benign myoepithelioma characterized by the presence of a minor ductal component. + termDef: + term: >- + Mixed Tumor, Not Otherwise Specified + source: NCIt + cde_id: C121786 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121786" + term_id: C121786 + term_version: 20.05a + +mixed_tumor_salivary_gland_type_malignant: + common: + description: >- + A malignant tumor arising from the salivary gland. It includes carcinoma ex + pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing + pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of + malignant epithelial and sarcomatous elements. + termDef: + term: >- + Malignant Mixed Tumor of the Salivary Gland + source: NCIt + cde_id: C8025 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8025" + term_id: C8025 + term_version: 20.05a + +mixed_tumor_salivary_gland_type_nos: + common: + description: >- + A neoplasm characterized by the presence of benign epithelial and myoepithelial + cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, + or osseous areas. It may be completely or partially encapsulated. It occurs + in the parotid gland, submandibular gland, minor salivary glands in the oral + cavity, upper respiratory tract, and nasal cavity and paranasal sinuses. It + usually presents as a slow growing painless mass. Infrequently, patients may + present with pain and facial palsy. It may recur after excision or transform + to a malignant neoplasm (carcinoma ex pleomorphic adenoma). + termDef: + term: >- + Pleomorphic Adenoma + source: NCIt + cde_id: C8602 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8602" + term_id: C8602 + term_version: 20.05a + +mkl1: + common: + description: >- + This gene is involved in transcriptional modulation and muscle cell differentiation. + termDef: + term: >- + MRTFA Gene + source: NCIt + cde_id: C97296 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97296" + term_id: C97296 + term_version: 20.10d + +mlf1: + common: + description: >- + This gene plays a role in both transcriptional regulation and cell cycle arrest. + termDef: + term: >- + MLF1 Gene + source: NCIt + cde_id: C97650 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97650" + term_id: C97650 + term_version: 20.10d + +mlh1: + common: + description: >- + This gene plays a role in DNA mismatch repair. + termDef: + term: >- + MLH1 Gene + source: NCIt + cde_id: C18482 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18482" + term_id: C18482 + term_version: 20.10d + +mlh2: + common: + description: >- + This gene is involved in mismatch repair and mutations in the gene result in + hereditary non-polyposis colon cancer 3. + termDef: + term: >- + PMS1 Gene + source: NCIt + cde_id: C18590 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18590" + term_id: C18590 + term_version: 20.10d + +mllt1: + common: + description: >- + This gene is involved in transcriptional regulation and translocations in the + gene are associated with acute leukemia. + termDef: + term: >- + MLLT1 Gene + source: NCIt + cde_id: C24601 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24601" + term_id: C24601 + term_version: 20.10d + +mllt10: + common: + description: >- + This gene may be involved in transcriptional regulation. + termDef: + term: >- + MLLT10 Gene + source: NCIt + cde_id: C84461 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84461" + term_id: C84461 + term_version: 20.10d + +mllt11: + common: + description: >- + This gene is involved in mitochondrial functions. + termDef: + term: >- + MLLT11 Gene + source: NCIt + cde_id: C97387 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97387" + term_id: C97387 + term_version: 20.10d + +mllt3: + common: + description: >- + This gene plays a role in transcriptional regulation and translocations in the + gene are associated with leukemia. + termDef: + term: >- + MLLT3 Gene + source: NCIt + cde_id: C24603 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24603" + term_id: C24603 + term_version: 20.10d + +mllt4: + common: + description: >- + This gene is involved in cell adhesion and cytoskeletal modeling + termDef: + term: >- + AFDN Gene + source: NCIt + cde_id: C24604 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24604" + term_id: C24604 + term_version: 20.10d + +mllt6: + common: + description: >- + This gene is involved in transcriptional regulation and aberrations in the gene + are associated with acute leukemias due to chromosomal translocations. + termDef: + term: >- + MLLT6 Gene + source: NCIt + cde_id: C24605 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24605" + term_id: C24605 + term_version: 20.10d + +mn1: + common: + description: >- + This gene is involved in tumor suppression. + termDef: + term: >- + MN1 Gene + source: NCIt + cde_id: C97618 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97618" + term_id: C97618 + term_version: 20.10d + +mnx1: + common: + description: >- + This gene plays a role in both the regulation of transcription and DNA binding. + termDef: + term: >- + MNX1 Gene + source: NCIt + cde_id: C97559 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97559" + term_id: C97559 + term_version: 20.10d + +mobocertinib: + common: + description: >- + An orally available inhibitor of specific mutant forms of both human epidermal + growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2; + ERBB2), with potential antineoplastic activity. Upon oral administration, mobocertinib + specifically and irreversibly binds to and inhibits certain mutant forms of + EGFR and HER2. This prevents EGFR- and HER2-mediated signaling and leads to + cell death in EGFR mutant- and HER2 mutant-expressing tumor cells. EGFR and + HER2, receptor tyrosine kinases mutated in many tumor cell types, play key roles + in tumor cell proliferation and tumor vascularization. + termDef: + term: >- + Mobocertinib + source: NCIt + cde_id: C126752 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126752" + term_id: C126752 + term_version: 20.10d + +modakafusp_alfa: + common: + description: >- + A proprietary preparation composed of an immunoglobulin G4 (IgG4) directed against + the cell surface glycoprotein CD-38 (CD38) that is fused to an attenuated form + of human interferon alpha (IFN alpha; IFNa), with potential immunomodulating + and antineoplastic activities. Upon administration, modakafusp alfa specifically + targets and binds to CD38 on CD38-positive tumor cells. In turn, the IFNa moiety + binds to cell-surface IFN receptors, and activates IFN-mediated signal transduction + pathways, which results in the transcription and translation of genes whose + products may cause antiproliferative effects in CD38-positive tumor cells. CD38, + a type II transmembrane glycoprotein, is present on various immune cells and + hematologic malignancies, and its expression has been correlated with poor prognosis. + termDef: + term: >- + Modakafusp Alfa + source: NCIt + cde_id: C140427 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140427" + term_id: C140427 + term_version: 20.10d + +moderate: + common: + description: >- + The quality of being within reasonable or average limits; not excessive or extreme. + termDef: + term: >- + Moderate + source: NCIt + cde_id: C61376 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61376" + term_id: C61376 + term_version: 20.10d + +modified_vaccinia_ankaravectored_hpv1618_vaccine_jnj65195208: + common: + description: >- + A booster cancer vaccine comprised of a modified, replication-defective, vaccinia + virus Ankara (MVA) Bavarian Nordic (MVA-BN) strain encoding the oncogenic human + papillomavirus types 16 (HPV16) and 18 (HPV18), with potential immunostimulating + and antineoplastic activities. Upon intramuscular administration of MVA-vectored + HPV16/18 vaccine JNJ-65195208, and after the administration of the prime vaccine(s) + adenovirus serotype 26 (Ad26)-expressing HPV16 vaccine JNJ-63682918 and/or Ad26-expressing + HPV18 vaccine JNJ-63682931, this vaccine further stimulates the host immune + system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells + expressing HPV16/18 proteins, resulting in tumor cell lysis. HPV16/18 infection + plays a key role in the development of a variety of cancers. + termDef: + term: >- + Modified Vaccinia Ankara-vectored HPV16/18 Vaccine JNJ-65195208 + source: NCIt + cde_id: C167362 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167362" + term_id: C167362 + term_version: 20.10d + +moldova: + common: + description: >- + A country in eastern Europe, northeast of Romania. + termDef: + term: >- + Moldova + source: NCIt + cde_id: C16871 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16871" + term_id: C16871 + term_version: 19.12e + +monaco: + common: + description: >- + A country in western Europe, bordering the Mediterranean Sea on the southern + coast of France, near the border with Italy. + termDef: + term: >- + Monaco + source: NCIt + cde_id: C16874 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16874" + term_id: C16874 + term_version: 19.12e + +mongolia: + common: + description: >- + A country in northern Asia, between China and Russia. + termDef: + term: >- + Mongolia + source: NCIt + cde_id: C16875 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16875" + term_id: C16875 + term_version: 19.12e + +monoblastic_leukemia_nos: + common: + description: >- + An acute myeloid leukemia in which the monoblasts represent 80% or more of the + total cellular population. (WHO, 2001) + termDef: + term: >- + Acute Monoblastic Leukemia + source: NCIt + cde_id: C7171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7171" + term_id: C7171 + term_version: 20.05a + +monoclonal_gammopathy_nos: + common: + description: >- + A condition in which an abnormal amount of a single immunoglobulin is present + in the serum. This category includes IgM monoclonal gammopathy of undetermined + significance and non-IgM monoclonal gammopathy of undetermined significance. + Up to 25% of cases of monoclonal gammopathy of undetermined significance progress + to a B-cell malignancy or myeloma. + termDef: + term: >- + Monoclonal Gammopathy of Undetermined Significance + source: NCIt + cde_id: C3996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3996" + term_id: C3996 + term_version: 20.05a + +monoclonal_gammopathy_of_undetermined_significance: + common: + description: >- + A condition in which an abnormal amount of a single immunoglobulin is present + in the serum. This category includes IgM monoclonal gammopathy of undetermined + significance and non-IgM monoclonal gammopathy of undetermined significance. + Up to 25% of cases of monoclonal gammopathy of undetermined significance progress + to a B-cell malignancy or myeloma. + termDef: + term: >- + Monoclonal Gammopathy of Undetermined Significance + source: NCIt + cde_id: C3996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3996" + term_id: C3996 + term_version: 20.05a + +monocytic_leukemia_nos: + common: + description: >- + An acute myeloid leukemia in which the majority of monocytic cells are promonocytes. (WHO, + 2001) + termDef: + term: >- + Acute Monocytic Leukemia + source: NCIt + cde_id: C4861 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4861" + term_id: C4861 + term_version: 20.05a + +monocytoid_bcell_lymphoma: + common: + description: >- + A primary nodal B-cell non-Hodgkin lymphoma which morphologically resembles + lymph nodes involved by marginal zone lymphomas of extranodal or splenic types, + but without evidence of extranodal or splenic disease. (WHO, 2001) + termDef: + term: >- + Nodal Marginal Zone Lymphoma + source: NCIt + cde_id: C8863 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8863" + term_id: C8863 + term_version: 20.05a + +monomorphic_adenoma: + common: + description: >- + A benign epithelial neoplasm arising from the salivary glands. It is characterized + by the presence of a monomorphic cellular infiltrate. + termDef: + term: >- + Salivary Gland Monomorphic Adenoma + source: NCIt + cde_id: C3686 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3686" + term_id: C3686 + term_version: 20.05a + +montenegro: + common: + description: >- + A country in southeastern Europe, bordering the Adriatic Sea, between Albania + and Bosnia and Herzegovina. + termDef: + term: >- + Montenegro + source: NCIt + cde_id: C64378 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64378" + term_id: C64378 + term_version: 19.12e + +montserrat: + common: + description: >- + An island in the Caribbean Seas, southeast of Saint Kitts and Nevis. + termDef: + term: >- + Montserrat + source: NCIt + cde_id: C16876 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16876" + term_id: C16876 + term_version: 19.12e + +morocco: + common: + description: >- + A country in northern Africa, bordering the North Atlantic Ocean and the Mediterranean + Sea, south of Spain and between Algeria and Western Sahara. + termDef: + term: >- + Morocco + source: NCIt + cde_id: C16878 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16878" + term_id: C16878 + term_version: 19.12e + +mosaicism: + common: + description: >- + The presence of more than one genetically distinct cell line in germ and/or + somatic cells. + termDef: + term: >- + Mosaicism + source: NCIt + cde_id: C92976 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92976" + term_id: C92976 + term_version: 20.10d + +mother: + common: + description: >- + A female parent. + termDef: + term: >- + Mother + source: NCIt + cde_id: C25189 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25189" + term_id: C25189 + term_version: 19.12e + +motherinlaw: + common: + description: >- + The mother of your spouse. + termDef: + term: >- + Mother-in-law + source: NCIt + cde_id: C68639 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68639" + term_id: C68639 + term_version: 19.12e + +motixafortide: + common: + description: >- + An orally bioavailable inhibitor of CXC Chemokine Receptor 4 (CXCR4) with potential + antineoplastic activity. CXCR4 antagonist BL-8040 selectively binds to the chemokine + receptor CXCR4, preventing the binding of stromal derived factor 1 (SDF-1 or + CXCL12) to the CXCR4 receptor and subsequent receptor activation, which may + result in decreased tumor cell proliferation and migration. In addition, inhibition + of CXCR4 may induce mobilization of hematopoietic cells from the bone marrow + into blood. The G protein-coupled receptor CXCR4 plays an important role in + chemotaxis and angiogenesis and is upregulated in several tumor cell types; + SDF-1/CXCR4 interaction induces retention of hematopoietic cells in the bone + marrow. + termDef: + term: >- + Motixafortide + source: NCIt + cde_id: C88309 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C88309" + term_id: C88309 + term_version: 20.10d + +motor_or_movement_changes: + common: + description: >- + An alteration in the motor/movement of an individual. + termDef: + term: >- + Motor / Movement Change + source: NCIt + cde_id: C157433 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157433" + term_id: C157433 + term_version: 20.05a + +mouth_nos: + common: + description: >- + The cavity located at the upper end of the alimentary canal, behind the teeth + and gums that is bounded on the outside by the lips, above by the hard and soft + palates and below by the tongue. + termDef: + term: >- + Oral Cavity + source: NCIt + cde_id: C12421 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12421" + term_id: C12421 + term_version: 20.05a + +mozambique: + common: + description: >- + A country in southeastern Africa, bordering the Mozambique Channel, between + South Africa and Tanzania. + termDef: + term: >- + Mozambique + source: NCIt + cde_id: C16882 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16882" + term_id: C16882 + term_version: 19.12e + +mpl: + common: + description: >- + This gene plays a regulatory role in megakaryocytopoiesis and platelet formation. + termDef: + term: >- + MPL Gene + source: NCIt + cde_id: C18411 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18411" + term_id: C18411 + term_version: 20.10d + +mpnst_nos: + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +mpnst_with_rhabdomyoblastic_differentiation: + common: + description: >- + A malignant peripheral nerve sheath tumor which shows rhabdomyosarcomatous differentiation. + More than half of the patients have neurofibromatosis type 1. The prognosis + is usually poor. + termDef: + term: >- + Malignant Triton Tumor + source: NCIt + cde_id: C4335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4335" + term_id: C4335 + term_version: 20.05a + +mrminimalmarginal_response: + common: + description: >- + Some response with no new symptoms or disease and not meeting partial response. + termDef: + term: >- + Minor Response + source: NCIt + cde_id: C123598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123598" + term_id: C123598 + term_version: 20.05a + +mrna: + common: + description: >- + A class of RNA molecule containing protein-coding information in its nucleotide + sequence that can be translated into the amino acid sequence of a protein. + termDef: + term: >- + Messenger RNA + source: NCIt + cde_id: C813 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C813" + term_id: C813 + term_version: 20.10d + +ms: + common: + description: >- + INRG stage L1 or L2 neuroblastoma with metastatic disease confined to the skin + and/or liver and/or bone marrow. + termDef: + term: >- + INRG Stage MS + source: NCIt + cde_id: C133431 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C133431" + term_id: C133431 + term_version: 20.05a + +msh2: + common: + description: >- + This gene plays a role in DNA mismatch repair mutations in the gene result in + hereditary nonpolyposis colorectal cancer-1. + termDef: + term: >- + MSH2 Gene + source: NCIt + cde_id: C18481 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18481" + term_id: C18481 + term_version: 20.10d + +msh6: + common: + description: >- + This gene is involved in mismatch repair and plays a role in several cancers. + termDef: + term: >- + MSH6 Gene + source: NCIt + cde_id: C19195 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19195" + term_id: C19195 + term_version: 20.10d + +msi2: + common: + description: >- + This gene is involved in translational regulation. + termDef: + term: >- + MSI2 Gene + source: NCIt + cde_id: C91356 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C91356" + term_id: C91356 + term_version: 20.10d + +msn: + common: + description: >- + This gene plays a role in both cell adhesion and cytoskeleton modeling. + termDef: + term: >- + MSN Gene + source: NCIt + cde_id: C97621 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97621" + term_id: C97621 + term_version: 20.10d + +mtcp1: + common: + description: >- + This gene plays a role in the proliferation of T cells and is involved in cell + cycle regulation. + termDef: + term: >- + MTCP1 Gene + source: NCIt + cde_id: C24617 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24617" + term_id: C24617 + term_version: 20.10d + +mtor: + common: + description: >- + This gene plays a role in apoptosis, cell growth, differentiation and proliferation. + termDef: + term: >- + MTOR Gene + source: NCIt + cde_id: C38928 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38928" + term_id: C38928 + term_version: 20.10d + +mu_heavy_chain_disease: + common: + description: >- + A clonal disorder characterized by the secretion of a mu heavy chain that lacks + a variable region. Most patients present with slowly progressive chronic lymphocytic + leukemia (CLL). In contrast to most cases of CLL, Mu heavy chain disease is + associated with hepatosplenomegaly and absence of lymphadenopathy. + termDef: + term: >- + Mu Heavy Chain Disease + source: NCIt + cde_id: C3892 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3892" + term_id: C3892 + term_version: 20.05a + +muc1: + common: + description: >- + This gene plays a role in cellular signal transduction and is used as a biomarker + for breast cancer. + termDef: + term: >- + MUC1 Gene + source: NCIt + cde_id: C38939 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38939" + term_id: C38939 + term_version: 20.10d + +muc16: + common: + description: >- + This gene is involved in both cellular adhesion and the maintenance of mucosal + surfaces. + termDef: + term: >- + MUC16 Gene + source: NCIt + cde_id: C71018 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71018" + term_id: C71018 + term_version: 20.10d + +muc1wt1_peptideprimed_autologous_dendritic_cells: + common: + description: >- + A cell-based cancer vaccine composed of autologous monocyte-derived dendritic + cells (DCs) loaded with the human tumor-associated antigens (TAAs) mucin-1 (MUC1) + and Wilms tumor protein 1 (WT1), with potential immunomodulating and antineoplastic + activities. Upon vaccination, the MUC-1/WT1 peptide-primed autologous DCs expose + the immune system to MUC1 and WT1 peptides and may stimulate the host immune + system to mount a cytotoxic T-lymphocyte (CTL) response against MUC1 and WT1-expressing + cancer cells, which could result in cancer cell lysis. MUC1 and WT1, are overexpressed + in a variety of tumor types and play an important role in tumor cell proliferation. + termDef: + term: >- + MUC-1/WT1 Peptide-primed Autologous Dendritic Cells + source: NCIt + cde_id: C174519 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174519" + term_id: C174519 + term_version: 20.10d + +muc4: + common: + description: >- + This gene is involved in both cell adhesion and receptor signaling. + termDef: + term: >- + MUC4 Gene + source: NCIt + cde_id: C128854 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128854" + term_id: C128854 + term_version: 20.10d + +mucinous_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +mucinous_adenocarcinoma_endocervical_type: + common: + description: >- + A mucinous adenocarcinoma characterized by the presence of malignant glandular + cells which resemble the endocervical epithelium. + termDef: + term: >- + Mucinous Adenocarcinoma, Endocervical Type + source: NCIt + cde_id: C66953 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66953" + term_id: C66953 + term_version: 20.05a + +mucinous_adenofibroma_nos: + common: + description: >- + A benign or borderline adenofibroma characterized by the presence of epithelial + cells which contain intracytoplasmic mucin and a fibrotic stroma. A representative + example is the ovarian mucinous adenofibroma. + termDef: + term: >- + Mucinous Adenofibroma + source: NCIt + cde_id: C8978 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8978" + term_id: C8978 + term_version: 20.05a + +mucinous_adenoma: + common: + description: >- + A benign or low malignant potential cystic epithelial neoplasm composed of cells + which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, + appendix, and lung. + termDef: + term: >- + Mucinous Cystadenoma + source: NCIt + cde_id: C2973 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2973" + term_id: C2973 + term_version: 20.05a + +mucinous_carcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +mucinous_carcinoma_gastric_type: + common: + description: >- + A cervical mucinous adenocarcinoma showing gastric differentiation. + termDef: + term: >- + Cervical Mucinous Adenocarcinoma, Gastric Type + source: NCIt + cde_id: C127905 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127905" + term_id: C127905 + term_version: 20.05a + +mucinous_carcinoma_intestinal_type: + common: + description: >- + A cervical mucinous adenocarcinoma that resembles the large intestinal adenocarcinoma. + termDef: + term: >- + Cervical Mucinous Adenocarcinoma, Intestinal-Type + source: NCIt + cde_id: C40203 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40203" + term_id: C40203 + term_version: 20.05a + +mucinous_cystadenocarcinoma_nos: + common: + description: >- + An invasive adenocarcinoma characterized by cystic changes and the presence + of malignant glandular cells which contain intracytoplasmic mucin. It may arise + from the ovary, pancreas, appendix, and lung. + termDef: + term: >- + Mucinous Cystadenocarcinoma + source: NCIt + cde_id: C3776 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3776" + term_id: C3776 + term_version: 20.05a + +mucinous_cystadenofibroma_nos: + common: + description: >- + A benign neoplasm characterized by the presence of cystic structures lined by + mucinous columnar epithelial cells in a fibrotic stroma. + termDef: + term: >- + Mucinous Cystadenofibroma + source: NCIt + cde_id: C8979 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8979" + term_id: C8979 + term_version: 20.05a + +mucinous_cystadenoma_nos: + common: + description: >- + A benign or low malignant potential cystic epithelial neoplasm composed of cells + which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, + appendix, and lung. + termDef: + term: >- + Mucinous Cystadenoma + source: NCIt + cde_id: C2973 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2973" + term_id: C2973 + term_version: 20.05a + +mucinous_cystic_tumor_with_moderate_dysplasia: + common: + description: >- + A non-invasive mucinous cystic neoplasm that arises from the pancreas and is + characterized by the presence of moderate dysplasia. The neoplastic columnar + mucin-producing epithelial cells form papillary projections or crypt-like invaginations. + There is cellular pseudostratification and mitotic activity present. + termDef: + term: >- + Pancreatic Mucinous-Cystic Neoplasm with Intermediate Grade Dysplasia + source: NCIt + cde_id: C6883 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6883" + term_id: C6883 + term_version: 20.05a + +mucinous_cystoma: + common: + description: >- + A benign or low malignant potential cystic epithelial neoplasm composed of cells + which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, + appendix, and lung. + termDef: + term: >- + Mucinous Cystadenoma + source: NCIt + cde_id: C2973 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2973" + term_id: C2973 + term_version: 20.05a + +mucinous_tubular_and_spindle_cell_carcinoma: + common: + description: >- + A low grade carcinoma of the kidney characterized by the presence of tubules + which are separated by mucinous stroma. Often the tubular structures have a + spindle cell appearance. Patients are usually asymptomatic and occasionally + they may present with hematuria or flank pain. + termDef: + term: >- + Mucinous Tubular and Spindle Cell Carcinoma of the Kidney + source: NCIt + cde_id: C39807 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39807" + term_id: C39807 + term_version: 20.05a + +mucinproducing_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which produce + mucin. + termDef: + term: >- + Mucin-Producing Adenocarcinoma + source: NCIt + cde_id: C27379 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27379" + term_id: C27379 + term_version: 20.05a + +mucinproducing_carcinoma: + common: + description: >- + A carcinoma that produces mucin. + termDef: + term: >- + Mucin-Producing Carcinoma + source: NCIt + cde_id: C27825 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27825" + term_id: C27825 + term_version: 20.05a + +mucinsecreting_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which produce + mucin. + termDef: + term: >- + Mucin-Producing Adenocarcinoma + source: NCIt + cde_id: C27379 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27379" + term_id: C27379 + term_version: 20.05a + +mucinsecreting_carcinoma: + common: + description: >- + A carcinoma that produces mucin. + termDef: + term: >- + Mucin-Producing Carcinoma + source: NCIt + cde_id: C27825 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27825" + term_id: C27825 + term_version: 20.05a + +mucoepidermoid_carcinoma: + common: + description: >- + A carcinoma morphologically characterized the presence of cuboidal mucous cells, + goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal + formation. It can occur in several anatomic sites, including parotid gland, + oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. + It is classified as low or high grade. + termDef: + term: >- + Mucoepidermoid Carcinoma + source: NCIt + cde_id: C3772 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3772" + term_id: C3772 + term_version: 20.05a + +mucoid_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +mucoid_carcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +mucoid_cell_adenocarcinoma: + common: + description: >- + A malignant epithelial neoplasm of the anterior pituitary gland in which the + neoplastic cells stain positive with basic dyes. + termDef: + term: >- + Basophilic Adenocarcinoma + source: NCIt + cde_id: C4150 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4150" + term_id: C4150 + term_version: 20.05a + +mucoid_cell_adenoma: + common: + description: >- + An epithelial neoplasm of the anterior pituitary gland in which the neoplastic + cells stain positive with basic dyes. + termDef: + term: >- + Pituitary Gland Basophil Adenoma + source: NCIt + cde_id: C2856 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2856" + term_id: C2856 + term_version: 20.05a + +mucosa_of_lip_nos: + common: + description: >- + The lining of the fleshy folds surrounding the mouth. It is comprised of the + epithelium, basement membrane, lamina propria mucosae, and lamina muscularis + mucosae. + termDef: + term: >- + Mucosa of the Lip + source: NCIt + cde_id: C12226 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12226" + term_id: C12226 + term_version: 20.05a + +mucosa_of_lower_lip: + common: + description: >- + The lining of the inferior fleshy fold bordering the mouth. It is comprised + of the epithelium, basement membrane, lamina propria mucosae, and lamina muscularis + mucosae. + termDef: + term: >- + Mucosa of the Lower Lip + source: NCIt + cde_id: C12225 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12225" + term_id: C12225 + term_version: 20.05a + +mucosa_of_upper_lip: + common: + description: >- + The lining of the superior fleshy fold bordering the mouth. It is comprised + of the epithelium, basement membrane, lamina propria mucosae, and lamina muscularis + mucosae. + termDef: + term: >- + Mucosa of the Upper Lip + source: NCIt + cde_id: C12224 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12224" + term_id: C12224 + term_version: 20.05a + +mucosal_lentiginous_melanoma: + common: + description: >- + An acral lentiginous melanoma affecting mucosal surfaces. + termDef: + term: >- + Mucosal Lentiginous Melanoma + source: NCIt + cde_id: C48622 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48622" + term_id: C48622 + term_version: 20.05a + +mucosalassociated_lymphoid_tissue_lymphoma: + common: + description: >- + An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes + (centrocyte-like cells). The gastrointestinal tract is the most common site + of involvement. Other common sites of involvement include lung, head and neck, + ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated + with the presence of H. pylori infection. (WHO, 2001) + termDef: + term: >- + Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue + source: NCIt + cde_id: C3898 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3898" + term_id: C3898 + term_version: 20.05a + +mucous_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +mucous_carcinoma: + common: + description: >- + An invasive adenocarcinoma composed of malignant glandular cells which contain + intracytoplasmic mucin. Often, the infiltrating glandular structures are associated + with mucoid stromal formation. It may arise from the large and small intestine, + appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary + gland. + termDef: + term: >- + Mucinous Adenocarcinoma + source: NCIt + cde_id: C26712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26712" + term_id: C26712 + term_version: 20.05a + +mullerian_adenosarcoma: + common: + description: >- + A low grade malignant neoplasm characterized by the presence of a benign epithelial + component (tubular and cleft-like glands) and a low grade sarcomatous component + that contains varying amounts of fibrous and smooth muscle tissues. In a minority + of cases, the sarcomatous component contains heterologous elements including + striated muscle, cartilage, and fat. It occurs in the uterine corpus, ovary, + fallopian tube, cervix, and vagina. It may recur and in a minority of cases + may metastasize to distant anatomic sites. + termDef: + term: >- + Adenosarcoma + source: NCIt + cde_id: C9474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9474" + term_id: C9474 + term_version: 20.05a + +mullerian_mixed_tumor: + common: + description: >- + A group of tumors affecting the female reproductive system, characterized by + the presence of epithelial and stromal elements. It includes the following clinicopathological + entities: adenofibroma, adenomyoma, Mullerian adenosarcoma, and malignant mixed + mesodermal (Mullerian) tumor. + termDef: + term: >- + Mixed Mesodermal (Mullerian) Tumor + source: NCIt + cde_id: C3730 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3730" + term_id: C3730 + term_version: 20.05a + +multicentric_basal_cell_carcinoma: + common: + description: >- + A superficial basal cell carcinoma of the skin characterized by the presence + of lobules of basaloid cells which are separated by large distances and represent + multifocal discrete tumors. + termDef: + term: >- + Superficial Multifocal Basal Cell Carcinoma + source: NCIt + cde_id: C4108 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4108" + term_id: C4108 + term_version: 20.05a + +multiepitope_her2_peptide_vaccine_tpiv100: + common: + description: >- + A cancer peptide vaccine comprised of four peptides derived from the tumor-associated + antigen (TAA) HER-2/neu (ErbB-2), with potential immunomodulating and antineoplastic + activities. Upon administration of the multi-epitope HER2 peptide vaccine TPIV100, + the four peptides may induce a cytotoxic T-lymphocyte (CTL)-mediated immune + response against tumor cells expressing the HER-2/neu antigen, which may result + in the inhibition of proliferation in Her-2/neu-expressing tumor cells. Her-2/neu, + a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, + is overexpressed in various tumor cell types. To enhance immunity, the peptides + are admixed with the adjuvant granulocyte macrophage-colony-stimulating factor + (GM-CSF). + termDef: + term: >- + Multi-epitope HER2 Peptide Vaccine TPIV100 + source: NCIt + cde_id: C173525 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173525" + term_id: C173525 + term_version: 20.10d + +multifocal: + common: + description: >- + Arising from, pertaining to, or having many locations. + termDef: + term: >- + Multifocal + source: NCIt + cde_id: C25253 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25253" + term_id: C25253 + term_version: 20.05a + +multifocal_superficial_basal_cell_carcinoma: + common: + description: >- + A superficial basal cell carcinoma of the skin characterized by the presence + of lobules of basaloid cells which are separated by large distances and represent + multifocal discrete tumors. + termDef: + term: >- + Superficial Multifocal Basal Cell Carcinoma + source: NCIt + cde_id: C4108 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4108" + term_id: C4108 + term_version: 20.05a + +multiple_adenomatous_polyps: + common: + description: >- + A condition in which multiple adenomas develop in the gastrointestinal tract. + termDef: + term: >- + Multiple Adenomatous Polyps + source: NCIt + cde_id: C4135 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4135" + term_id: C4135 + term_version: 20.05a + +multiple_endocrine_adenomas: + common: + description: >- + An autosomal dominant inherited neoplastic syndrome characterized by the development + of various endocrine neoplasms and abnormalities in various anatomic sites. + There are four types recognized: type 1 (MEN 1), caused by inactivation of the + tumor suppressor gene MEN-1, type 2A (MEN 2A), caused by mutation of the RET + gene, type 2B (MEN 2B) also caused by mutation of the RET gene, and type 4 (MEN + 4) caused by mutation of the CDKN1B gene. Patients with MEN 1 may develop hyperparathyroidism + and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell + neoplasms, and carcinoid tumors. Patients with MEN 2A develop medullary thyroid + carcinomas and may also develop pheochromocytomas and parathyroid gland hyperplasia. + Patients with MEN 2B develop medullary thyroid carcinomas and numerous neural + defects including neuromas. Patients with MEN 4 develop endocrine neoplasms, + particularly in the parathyroid glands, pituitary, and pancreas. + termDef: + term: >- + Multiple Endocrine Neoplasia + source: NCIt + cde_id: C6432 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6432" + term_id: C6432 + term_version: 20.05a + +multiple_hemorrhagic_sarcoma: + common: + description: >- + A malignant neoplasm characterized by a vascular proliferation which usually + contains blunt endothelial cells. Erythrocyte extravasation and hemosiderin + deposition are frequently present. The most frequent site of involvement is + the skin; however it may also occur internally. It generally develops in people + with compromised immune systems including those with acquired immune deficiency + syndrome (AIDS). + termDef: + term: >- + Kaposi Sarcoma + source: NCIt + cde_id: C9087 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9087" + term_id: C9087 + term_version: 20.05a + +multiple_meningiomas: + common: + description: >- + The presence of multiple meningiomas in the leptomeninges. + termDef: + term: >- + Meningiomatosis + source: NCIt + cde_id: C3707 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3707" + term_id: C3707 + term_version: 20.05a + +multiple_myeloma: + common: + description: >- + A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal + protein and skeletal destruction with osteolytic lesions, pathological fractures, + bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory + myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. + termDef: + term: >- + Plasma Cell Myeloma + source: NCIt + cde_id: C3242 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3242" + term_id: C3242 + term_version: 19.12e + +multiple_neurofibromatosis: + common: + description: >- + An autosomal dominant hereditary neoplastic syndrome. Two distinct clinicopathological + entities are recognized: neurofibromatosis type 1 and neurofibromatosis type + 2. Neurofibromatosis type 1 is associated with the presence of cafe-au-lait + cutaneous lesions, multiple neurofibromas, malignant peripheral nerve sheath + tumors, optic nerve gliomas, and bone lesions. Neurofibromatosis type 2 is associated + with the presence of schwannomas, meningiomas, and gliomas. + termDef: + term: >- + Neurofibromatosis + source: NCIt + cde_id: C6727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6727" + term_id: C6727 + term_version: 20.05a + +murizatoclax: + common: + description: >- + An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid + cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic + activities. Upon administration, MCL-1 inhibitor AMG 397 targets and binds to + Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain + pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. + Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) + family of proteins, is upregulated in cancer cells and promotes tumor cell survival. + termDef: + term: >- + Murizatoclax + source: NCIt + cde_id: C156740 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156740" + term_id: C156740 + term_version: 20.10d + +muscadine_grape_extract: + common: + description: >- + An extract derived from the Muscadine grape (Vitis rotundifolia), with potential + anti-inflammatory, antioxidant, anti-lipidemic and chemopreventive activities. + The muscadine grape extract (MGE) contains numerous phytochemicals including + hydrolyzable tannins and flavonoids, such as resveratrol, anthocyanin 3,5-diglucosides, + quercetin, ellagic acid, myricetin, and kaempferol glycosides. Upon administration, + the active components in the MGE scavenge free radicals, protect against oxidation + of low-density lipoprotein (LDL), and inhibit cell damage due to reactive oxygen + species (ROS). This inhibits oxidative stress and protects against DNA damage. + MGE also inhibits enzymes involved in inflammation, cell replication and DNA + synthesis, and induces the expression of anti-oxidant enzymes. The active ingredients + may also inhibit certain signaling pathways upregulated in some tumor cell types, + eventually leading to apoptosis and a reduction in tumor cell proliferation. + MGE may also boost energy and prevent fatigue. + termDef: + term: >- + Muscadine Grape Extract + source: NCIt + cde_id: C175526 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175526" + term_id: C175526 + term_version: 20.10d + +muscle_tissue: + common: + description: >- + Tissue responsible for the body movements and the shape and size changes of + internal organs. Muscle tissue is composed of specialized contractile cells. + There are two types of muscle tissue recognized: striated and smooth muscle. + The striated muscle tissue is further subdivided into skeletal, visceral striated, + and cardiac muscle. + termDef: + term: >- + Muscle Tissue + source: NCIt + cde_id: C12435 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12435" + term_id: C12435 + term_version: 20.10d + +mutyh: + common: + description: >- + This gene plays a role in the repair of oxidative DNA damage. + termDef: + term: >- + MUTYH Gene + source: NCIt + cde_id: C61056 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61056" + term_id: C61056 + term_version: 20.10d + +mvabn_smallpox_vaccine: + common: + description: >- + A vaccine consisting of modified vaccinia Ankara-Bavarian Nordic (MVA-BN), a + live, attenuated, non-replicating, proprietary version of the MVA virus, used + for the prevention of smallpox and monkeypox, with potential antineoplastic + activity. Upon intratumoral administration, MVA-BN smallpox vaccine may induce + both cellular and humoral immune responses, which may lead to tumor cell lysis. + termDef: + term: >- + MVA-BN Smallpox Vaccine + source: NCIt + cde_id: C173552 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173552" + term_id: C173552 + term_version: 20.10d + +mx: + common: + description: >- + A distant metastasis TNM finding indicating that the status of distant metastasis + cannot be assessed. + termDef: + term: >- + MX Stage Finding + source: NCIt + cde_id: C48704 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48704" + term_id: C48704 + term_version: 20.05a + +mxmixed_response: + common: + description: >- + An indication that some disease characteristics are improving while others are + worsening over time. + termDef: + term: >- + Mixed Response + source: NCIt + cde_id: C165202 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165202" + term_id: C165202 + term_version: 20.05a + +myanmar: + common: + description: >- + A country in southeastern Asia, bordering the Andaman Sea and the Bay of Bengal, + southwest of China, between Bangladesh and Thailand. + termDef: + term: >- + Myanmar + source: NCIt + cde_id: C16370 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16370" + term_id: C16370 + term_version: 19.12e + +myb: + common: + description: >- + This gene plays a role in hematopoietic cell proliferation and development. + termDef: + term: >- + MYB Gene + source: NCIt + cde_id: C28569 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28569" + term_id: C28569 + term_version: 20.10d + +myc: + common: + description: >- + This gene plays a role in cell cycle progression and apoptosis. Cytogenetic + aberrations in the gene are involved in cellular transformation and are associated + with a variety of hematopoietic tumors, leukemias and lymphomas. + termDef: + term: >- + MYC Gene + source: NCIt + cde_id: C16887 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16887" + term_id: C16887 + term_version: 20.10d + +mycl: + common: + description: >- + This gene is involved in transcriptional regulation and is frequently amplified + in small-cell lung cancer. + termDef: + term: >- + MYCL Gene + source: NCIt + cde_id: C18407 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18407" + term_id: C18407 + term_version: 20.10d + +mycn: + common: + description: >- + This gene is involved in transcriptional regulation and amplification of this + gene is associated with a variety of tumors, most notably neuroblastomas. + termDef: + term: >- + MYCN Gene + source: NCIt + cde_id: C18405 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18405" + term_id: C18405 + term_version: 20.10d + +mycosis_fungoides: + common: + description: >- + A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques. + It is characterized by epidermal and dermal infiltration of small to medium-sized + T-cells with cerebriform nuclei. Patients with limited disease generally have + an excellent prognosis. In the more advanced stages, the prognosis is poor. + (WHO, 2001) + termDef: + term: >- + Mycosis Fungoides + source: NCIt + cde_id: C3246 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3246" + term_id: C3246 + term_version: 20.05a + +myd88: + common: + description: >- + This gene is involved in the modulation of proinflammatory gene expression. + termDef: + term: >- + MYD88 Gene + source: NCIt + cde_id: C90089 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C90089" + term_id: C90089 + term_version: 20.10d + +myeloblasts: + common: + description: >- + The determination of the number of myeloblast cells present in a sample. + termDef: + term: >- + Myeloblast Count + source: NCIt + cde_id: C74632 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74632" + term_id: C74632 + term_version: 20.10d + +myelocytes: + common: + description: >- + The determination of the number of myelocyte cells present in a sample. + termDef: + term: >- + Myelocyte Count + source: NCIt + cde_id: C74662 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74662" + term_id: C74662 + term_version: 20.10d + +myelocytic_leukemia_nos: + common: + description: >- + A clonal proliferation of myeloid cells and their precursors in the bone marrow, + peripheral blood, and spleen. When the proliferating cells are immature myeloid + cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating + myeloid cells are neutrophils, it is called chronic myelogenous leukemia. + termDef: + term: >- + Myeloid Leukemia + source: NCIt + cde_id: C3172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3172" + term_id: C3172 + term_version: 20.05a + +myelodysplastic_syndrome_nos: + common: + description: >- + A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis + in one or more of the hematopoietic cell lines. The dysplasia may be accompanied + by an increase in myeloblasts, but the number is less than 20%, which, according + to the WHO guidelines, is the requisite threshold for the diagnosis of acute + myeloid leukemia. It may occur de novo or as a result of exposure to alkylating + agents and/or radiotherapy. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome + source: NCIt + cde_id: C3247 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3247" + term_id: C3247 + term_version: 20.05a + +myelodysplastic_syndrome_unclassifiable: + common: + description: >- + A subtype of myelodysplastic syndrome which initially lacks findings appropriate + for classification into any other myelodysplastic category. There are no specific + morphologic findings. The diagnosis can be made in the following instances: + 1. in cases of refractory cytopenia with unilineage dysplasia or refractory + cytopenia with multilineage dysplasia but with 1% blasts in the peripheral blood; + 2: in cases of myelodysplastic syndrome with unilineage dysplasia which are + associated with pancytopenia; 3: in cases with persistent cytopenia (s) with + 1% or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal + dysplasia in less than 10% of the cells in one or more myeloid lineages, and + cytogenetic abnormalities considered as presumptive evidence of myelodysplastic + syndrome. (WHO, 2008) + termDef: + term: >- + Myelodysplastic Syndrome, Unclassifiable + source: NCIt + cde_id: C8648 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8648" + term_id: C8648 + term_version: 20.05a + +myelodysplastic_syndrome_with_5q_deletion_5q_syndrome: + common: + description: >- + A myelodysplastic syndrome characterized by a deletion between bands q31 and + 33 on chromosome 5. The number of blasts in the bone marrow and blood is <5%. The + bone marrow is usually hypercellular or normocellular with increased number + of often hypolobated megakaryocytes. The peripheral blood shows macrocytic + anemia. This syndrome occurs predominantly but not exclusively in middle age + to older women. The prognosis is good and transformation to acute leukemia + is rare. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Isolated del(5q) + source: NCIt + cde_id: C6867 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6867" + term_id: C6867 + term_version: 20.05a + +myelodysplastic_syndrome_with_isolated_del_5q: + common: + description: >- + A myelodysplastic syndrome characterized by a deletion between bands q31 and + 33 on chromosome 5. The number of blasts in the bone marrow and blood is <5%. The + bone marrow is usually hypercellular or normocellular with increased number + of often hypolobated megakaryocytes. The peripheral blood shows macrocytic + anemia. This syndrome occurs predominantly but not exclusively in middle age + to older women. The prognosis is good and transformation to acute leukemia + is rare. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Isolated del(5q) + source: NCIt + cde_id: C6867 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6867" + term_id: C6867 + term_version: 20.05a + +myelodysplasticmyeloproliferative_neoplasm_unclassifiable: + common: + description: >- + This entity includes cases that have clinical, laboratory, and morphologic features + that support the diagnosis of both a myelodysplastic syndrome and a myeloproliferative + neoplasm, but do not meet the criteria for any of the other entities included + in the myelodysplastic/myeloproliferative neoplasm category. (WHO, 2001) + termDef: + term: >- + Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable + source: NCIt + cde_id: C27780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27780" + term_id: C27780 + term_version: 20.05a + +myelofibrosis_as_a_result_of_myeloproliferative_disease: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, + proliferation of atypical megakaryocytes and granulocytes in the bone marrow, + anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001) + termDef: + term: >- + Primary Myelofibrosis + source: NCIt + cde_id: C2862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2862" + term_id: C2862 + term_version: 20.05a + +myelofibrosis_with_myeloid_metaplasia: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, + proliferation of atypical megakaryocytes and granulocytes in the bone marrow, + anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001) + termDef: + term: >- + Primary Myelofibrosis + source: NCIt + cde_id: C2862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2862" + term_id: C2862 + term_version: 20.05a + +myelogenous_leukemia_nos: + common: + description: >- + A clonal proliferation of myeloid cells and their precursors in the bone marrow, + peripheral blood, and spleen. When the proliferating cells are immature myeloid + cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating + myeloid cells are neutrophils, it is called chronic myelogenous leukemia. + termDef: + term: >- + Myeloid Leukemia + source: NCIt + cde_id: C3172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3172" + term_id: C3172 + term_version: 20.05a + +myeloid_and_lymphoid_neoplasms_with_pdgfra_rearrangement: + common: + description: >- + Hematologic neoplasms characterized by the rearrangement of the PDGFRA gene, + most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts. Patients + usually present with chronic eosinophilic leukemia, and less often with acute + myeloid leukemia or T-lymphoblastic leukemia. + termDef: + term: >- + Myeloid/Lymphoid Neoplasms with PDGFRA Rearrangement + source: NCIt + cde_id: C84275 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84275" + term_id: C84275 + term_version: 20.05a + +myeloid_leukemia_associated_with_down_syndrome: + common: + description: >- + Acute myeloid leukemia or myelodysplastic syndrome occurring in children with + Down syndrome. The acute myeloid leukemia is usually an acute megakaryoblastic + leukemia, and is associated with GATA1 gene mutation. + termDef: + term: >- + Myeloid Leukemia Associated with Down Syndrome + source: NCIt + cde_id: C43223 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43223" + term_id: C43223 + term_version: 20.05a + +myeloid_leukemia_nos: + common: + description: >- + A clonal proliferation of myeloid cells and their precursors in the bone marrow, + peripheral blood, and spleen. When the proliferating cells are immature myeloid + cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating + myeloid cells are neutrophils, it is called chronic myelogenous leukemia. + termDef: + term: >- + Myeloid Leukemia + source: NCIt + cde_id: C3172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3172" + term_id: C3172 + term_version: 20.05a + +myeloid_neoplasms_with_pdgfrb_rearrangement: + common: + description: >- + Myeloid and rarely lymphoid neoplasms characterized by the rearrangement of + the PDGFRB gene, most often resulting in the formation of ETV6-PDGFRB fusion + transcripts. Patients usually present with chronic myelomonocytic leukemia and + less often with atypical chronic myeloid leukemia, or chronic eosinophilic leukemia. + termDef: + term: >- + Myeloid/Lymphoid Neoplasms with PDGFRB Rearrangement + source: NCIt + cde_id: C84276 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84276" + term_id: C84276 + term_version: 20.05a + +myeloid_sarcoma: + common: + description: >- + A tumor mass composed of myeloblasts or immature myeloid cells. It occurs in + extramedullary sites or the bone. (WHO, 2001) + termDef: + term: >- + Myeloid Sarcoma + source: NCIt + cde_id: C3520 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3520" + term_id: C3520 + term_version: 20.05a + +myelolipoma: + common: + description: >- + A benign soft tissue lesion arising from the adrenal gland. It is composed + of mature adipose and hematopoietic/lymphoid tissues. + termDef: + term: >- + Adrenal Gland Myelolipoma + source: NCIt + cde_id: C3736 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3736" + term_id: C3736 + term_version: 20.05a + +myeloma_nos: + common: + description: >- + A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal + protein and skeletal destruction with osteolytic lesions, pathological fractures, + bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory + myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, + 2001) + termDef: + term: >- + Plasma Cell Myeloma + source: NCIt + cde_id: C3242 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3242" + term_id: C3242 + term_version: 20.05a + +myelomatosis: + common: + description: >- + A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal + protein and skeletal destruction with osteolytic lesions, pathological fractures, + bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory + myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, + 2001) + termDef: + term: >- + Plasma Cell Myeloma + source: NCIt + cde_id: C3242 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3242" + term_id: C3242 + term_version: 20.05a + +myeloproliferative_disease_nos: + common: + description: >- + A clonal hematopoietic stem cell disorder, characterized by proliferation in + the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, + megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. + (WHO 2008) + termDef: + term: >- + Myeloproliferative Neoplasm + source: NCIt + cde_id: C4345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4345" + term_id: C4345 + term_version: 20.05a + +myeloproliferative_neoplasm_nos: + common: + description: >- + A clonal hematopoietic stem cell disorder, characterized by proliferation in + the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, + megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. + (WHO 2008) + termDef: + term: >- + Myeloproliferative Neoplasm + source: NCIt + cde_id: C4345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4345" + term_id: C4345 + term_version: 20.05a + +myelosclerosis_with_myeloid_metaplasia: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, + proliferation of atypical megakaryocytes and granulocytes in the bone marrow, + anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001) + termDef: + term: >- + Primary Myelofibrosis + source: NCIt + cde_id: C2862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2862" + term_id: C2862 + term_version: 20.05a + +myh11: + common: + description: >- + This gene plays a regulatory role in muscle contraction and the required ATP + hydrolysis. + termDef: + term: >- + MYH11 Gene + source: NCIt + cde_id: C29957 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C29957" + term_id: C29957 + term_version: 20.10d + +myh9: + common: + description: >- + This gene is involved in both cytoskeleton modeling and cytokinesis. + termDef: + term: >- + MYH9 Gene + source: NCIt + cde_id: C97646 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97646" + term_id: C97646 + term_version: 20.10d + +myloproliferative_neoplasm_unclassifiable: + common: + description: >- + This entity includes cases that have clinical, laboratory, and morphologic features + that support the diagnosis of both a myelodysplastic syndrome and a myeloproliferative + neoplasm, but do not meet the criteria for any of the other entities included + in the myelodysplastic/myeloproliferative neoplasm category. (WHO, 2001) + termDef: + term: >- + Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable + source: NCIt + cde_id: C27780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27780" + term_id: C27780 + term_version: 20.05a + +myo5a: + common: + description: >- + This gene is involved in vesicle transport along actin filaments. + termDef: + term: >- + MYO5A Gene + source: NCIt + cde_id: C122881 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122881" + term_id: C122881 + term_version: 20.10d + +myod1: + common: + description: >- + This gene plays a role in DNA binding and myogenesis. + termDef: + term: >- + MYOD1 Gene + source: NCIt + cde_id: C93113 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93113" + term_id: C93113 + term_version: 20.10d + +myoepithelial_adenoma: + common: + description: >- + A tumor with myoepithelial differentiation that lacks an infiltrative growth + pattern and does not metastasize. + termDef: + term: >- + Benign Myoepithelioma + source: NCIt + cde_id: C7442 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7442" + term_id: C7442 + term_version: 20.05a + +myoepithelial_carcinoma: + common: + description: >- + An infiltrating malignant tumor characterized by the presence of atypical cells + with myoepithelial differentiation. Representative examples include malignant + breast myoepithelioma and salivary gland myoepithelial carcinoma. + termDef: + term: >- + Malignant Myoepithelioma + source: NCIt + cde_id: C7596 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7596" + term_id: C7596 + term_version: 20.05a + +myoepithelial_tumor: + common: + description: >- + A benign or malignant tumor characterized by the presence of cells that show + myoepithelial differentiation. Based on its morphologic features, it is classified + as benign or malignant. A representative example of benign myoepithelioma is + benign salivary gland myoepithelioma. Representative examples of malignant myoepithelioma + or myoepithelial carcinoma are malignant breast myoepithelioma and salivary + gland myoepithelial carcinoma. + termDef: + term: >- + Myoepithelial Tumor + source: NCIt + cde_id: C40392 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40392" + term_id: C40392 + term_version: 20.05a + +myoepithelioma: + common: + description: >- + A benign or malignant tumor characterized by the presence of cells that show + myoepithelial differentiation. Based on its morphologic features, it is classified + as benign or malignant. A representative example of benign myoepithelioma is + benign salivary gland myoepithelioma. Representative examples of malignant myoepithelioma + or myoepithelial carcinoma are malignant breast myoepithelioma and salivary + gland myoepithelial carcinoma. + termDef: + term: >- + Myoepithelial Tumor + source: NCIt + cde_id: C40392 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40392" + term_id: C40392 + term_version: 20.05a + +myofibroblastic_tumor_nos: + common: + description: >- + A multinodular intermediate fibroblastic neoplasm that arises from soft tissue + or viscera, in children and young adults. It is characterized by the presence + of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory + infiltrate composed of eosinophils, lymphocytes, and plasma cells. + termDef: + term: >- + Inflammatory Myofibroblastic Tumor + source: NCIt + cde_id: C6481 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6481" + term_id: C6481 + term_version: 20.05a + +myofibroblastoma: + common: + description: >- + A benign, well circumscribed soft tissue neoplasm characterized by the presence + of spindle shaped myofibroblasts and mast cells in a collagenous stroma. + termDef: + term: >- + Myofibroblastoma + source: NCIt + cde_id: C49012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49012" + term_id: C49012 + term_version: 20.05a + +myofibroma: + common: + description: >- + A benign, localized, nodular and well-circumscribed neoplasm usually seen as + a congenital neoplasm or in the first year of life. It is characterized by a + biphasic growth pattern and is composed of small, undifferentiated mesenchymal + cells associated with branching thin-walled vessels and more mature neoplastic + spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma. + termDef: + term: >- + Myofibroma + source: NCIt + cde_id: C7052 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7052" + term_id: C7052 + term_version: 20.05a + +myofibromatosis: + common: + description: >- + A benign, multifocal, nodular and well-circumscribed neoplasm usually seen as + a congenital neoplasm or in the first year of life. It is characterized by a + biphasic growth pattern and is composed of small, undifferentiated mesenchymal + cells associated with branching thin-walled vessels and more mature neoplastic + spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma. + termDef: + term: >- + Myofibromatosis + source: NCIt + cde_id: C3742 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3742" + term_id: C3742 + term_version: 20.05a + +myoma: + common: + description: >- + A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle + tissue. + termDef: + term: >- + Benign Muscle Neoplasm + source: NCIt + cde_id: C4882 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4882" + term_id: C4882 + term_version: 20.05a + +myometrium: + common: + description: >- + The smooth muscle lining the uterus. + termDef: + term: >- + Myometrium + source: NCIt + cde_id: C12314 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12314" + term_id: C12314 + term_version: 20.05a + +myosarcoma: + common: + description: >- + A malignant neoplasm affecting the skeletal or smooth muscles. Malignant neoplasms + arising from the skeletal muscles are called rhabdomyosarcomas. Malignant neoplasms + arising from the smooth muscles are called leiomyosarcomas. + termDef: + term: >- + Malignant Muscle Neoplasm + source: NCIt + cde_id: C4883 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4883" + term_id: C4883 + term_version: 20.05a + +myxofibroma_nos: + common: + description: >- + A soft tissue tumor of uncertain lineage characterized by the presence of neoplastic + spindle-shaped to round cells in a fibromyxoid stroma. Metaplastic bone formation + may or may not be present. + termDef: + term: >- + Fibromyxoid Tumor + source: NCIt + cde_id: C66760 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66760" + term_id: C66760 + term_version: 20.05a + +myxoid_chondrosarcoma: + common: + description: >- + A chondrosarcoma characterized by the presence of myxoid changes. + termDef: + term: >- + Myxoid Chondrosarcoma + source: NCIt + cde_id: C4303 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4303" + term_id: C4303 + term_version: 20.05a + +myxoid_fibroma: + common: + description: >- + A soft tissue tumor of uncertain lineage characterized by the presence of neoplastic + spindle-shaped to round cells in a fibromyxoid stroma. Metaplastic bone formation + may or may not be present. + termDef: + term: >- + Fibromyxoid Tumor + source: NCIt + cde_id: C66760 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66760" + term_id: C66760 + term_version: 20.05a + +myxoid_leiomyosarcoma: + common: + description: >- + A morphologic variant of leiomyosarcoma characterized by the presence of cellular + pleomorphism, malignant cells with large nuclei, and a myxoid stroma. + termDef: + term: >- + Myxoid Leiomyosarcoma + source: NCIt + cde_id: C3701 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3701" + term_id: C3701 + term_version: 20.05a + +myxoid_liposarcoma: + common: + description: >- + A liposarcoma characterized by the presence of round non-lipogenic primitive + mesenchymal cells and small signet ring lipoblasts within a myxoid stoma with + a branching vascular pattern. This category includes hypercellular lesions + with round cell morphology, formerly known as round cell liposarcoma. + termDef: + term: >- + Myxoid Liposarcoma + source: NCIt + cde_id: C27781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27781" + term_id: C27781 + term_version: 20.05a + +myxoinflammatory_fibroblastic_sarcoma_mifs: + common: + description: >- + A low grade, locally aggressive, fibroblastic neoplasm that occurs primarily + in the distal extremities. It is characterized by the presence of spindle-shaped + fibroblasts, multivacuolated lipoblast-like cells, bizarre ganglion-like cells + with inclusion-like nuclei, myxoid stroma formation, and a mixture of acute + and chronic inflammatory cells. Distant metastases are very rare. + termDef: + term: >- + Myxoinflammatory Fibroblastic Sarcoma + source: NCIt + cde_id: C49025 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49025" + term_id: C49025 + term_version: 20.05a + +myxolipoma: + common: + description: >- + A benign well-circumscribed tumor composed of mature adipocytes, characterized + by areas of abundant fibrous tissue and extensive myxoid change. + termDef: + term: >- + Fibromyxolipoma + source: NCIt + cde_id: C4251 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4251" + term_id: C4251 + term_version: 20.05a + +myxoliposarcoma: + common: + description: >- + A liposarcoma characterized by the presence of round non-lipogenic primitive + mesenchymal cells and small signet ring lipoblasts within a myxoid stoma with + a branching vascular pattern. This category includes hypercellular lesions + with round cell morphology, formerly known as round cell liposarcoma. + termDef: + term: >- + Myxoid Liposarcoma + source: NCIt + cde_id: C27781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27781" + term_id: C27781 + term_version: 20.05a + +myxoma_nos: + common: + description: >- + A benign soft tissue neoplasm characterized by the presence of spindle and stellate + cells, lobulated growth pattern, and myxoid stroma formation. + termDef: + term: >- + Myxoma + source: NCIt + cde_id: C6577 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6577" + term_id: C6577 + term_version: 20.05a + +myxopapillary_ependymoma: + common: + description: >- + A slow growing, WHO grade I glioma which generally occurs in young adults. It + arises almost exclusively in the conus medullaris, cauda equina, and filum terminale + of the spinal cord. It generally has a favorable prognosis and is characterized + histologically by tumor cells arranged in a papillary manner around vascularized + mucoid stromal cores. (Adapted from WHO). + termDef: + term: >- + Myxopapillary Ependymoma + source: NCIt + cde_id: C3697 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3697" + term_id: C3697 + term_version: 20.05a + +myxosarcoma: + common: + description: >- + An infiltrating malignant soft tissue neoplasm characterized by the presence + of immature undifferentiated cells and abundant myxoid stroma formation. + termDef: + term: >- + Myxosarcoma + source: NCIt + cde_id: C3255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3255" + term_id: C3255 + term_version: 20.05a + +n0: + common: + description: >- + A regional lymph node TNM finding indicating that there is no evidence of regional + lymph node metastasis. + termDef: + term: >- + N0 Stage Finding + source: NCIt + cde_id: C48705 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48705" + term_id: C48705 + term_version: 20.05a + diagnosis: + ensat_pathologic_n: + description: >- + Adrenal cancer with no involvement of regional lymph nodes. (7th Ed, 2009) + termDef: + term: >- + pN0 ENSAT Staging Finding v7 + source: NCIt + cde_id: C104024 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104024" + term_id: C104024 + term_version: 23.03d + +n0_i: + common: + description: >- + A regional lymph node TNM finding indicating that there are malignant cells + in regional lymph node(s) no greater than 0.2 mm and are detected by hematoxylin + and eosin stain or immunohistochemistry. + termDef: + term: >- + N0 (i+) Stage Finding + source: NCIt + cde_id: C95922 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95922" + term_id: C95922 + term_version: 20.05a + +n0_mol: + common: + description: >- + A regional lymph node TNM finding indicating that there is no evidence of regional + lymph node metastasis histologically and by immunohistochemistry, but the molecular + analysis (RT-PCR) is positive. + termDef: + term: >- + N0 (mol+) Stage Finding + source: NCIt + cde_id: C95925 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95925" + term_id: C95925 + term_version: 20.05a + +n1: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases usually in + a limited number of regional lymph nodes. The definition of N1 TNM finding depends + on the specific type of cancer that it refers to; for example, for breast cancer + it refers to micrometastases or metastases in 1-3 axillary lymph nodes; for + cutaneous melanoma it refers to metastasis in 1 regional lymph node; for colorectal + cancer it refers to metastases in 1-3 regional lymph nodes; and for bladder + cancer it refers to metastasis in 1 regional lymph node in the true pelvis. + termDef: + term: >- + N1 Stage Finding + source: NCIt + cde_id: C48706 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48706" + term_id: C48706 + term_version: 20.05a + diagnosis: + ensat_pathologic_n: + description: >- + Adrenal cancer with involvement of regional lymph nodes. (7th Ed, 2009) + termDef: + term: >- + pN1 ENSAT Staging Finding v7 + source: NCIt + cde_id: C104025 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104025" + term_id: C104025 + term_version: 23.03d + +n1a: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases usually in + a limited number of regional lymph nodes. The definition of N1a TNM finding + depends on the specific type of cancer that it refers to; for example, for breast + cancer it refers to metastasis in 1 to 3 axillary lymph nodes (at least 1 tumor + deposit greater than 2.0 mm); for cutaneous melanoma it refers to micrometastasis + in one regional lymph node; for colorectal cancer it refers to metastasis in + one regional lymph node. + termDef: + term: >- + N1a Stage Finding + source: NCIt + cde_id: C48707 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48707" + term_id: C48707 + term_version: 20.05a + +n1b: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases usually in + a limited number of regional lymph nodes. The definition of N1b TNM finding + depends on the specific type of cancer that it refers to; for example, for breast + cancer it refers to metastases in internal mammary lymph nodes with micrometastases + or macrometastases detected by sentinel lymph node biopsy but not clinically + detected; for cutaneous melanoma it refers to macrometastasis in one regional + lymph node; for colorectal cancer it refers to metastasis in 2-3 regional lymph + nodes. + termDef: + term: >- + N1b Stage Finding + source: NCIt + cde_id: C48708 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48708" + term_id: C48708 + term_version: 20.05a + +n1bi: + common: + description: >- + A regional lymph node TNM finding indicating that there is metastasis to 1-3 + nodes. The metastasis is greater than 2 mm and all are less than 20 mm. + termDef: + term: >- + N1bI Stage Finding + source: NCIt + cde_id: C95929 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95929" + term_id: C95929 + term_version: 20.05a + +n1bii: + common: + description: >- + A regional lymph node TNM finding indicating that there is metastasis to four + or more nodes. The metastasis is greater than 2 mm and all are less than 20 + mm. + termDef: + term: >- + N1bII Stage Finding + source: NCIt + cde_id: C95935 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95935" + term_id: C95935 + term_version: 20.05a + +n1biii: + common: + description: >- + A regional lymph node TNM finding indicating that the tumor extends beyond the + lymph node capsule and is less than 20 mm. + termDef: + term: >- + N1bIII Stage Finding + source: NCIt + cde_id: C95936 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95936" + term_id: C95936 + term_version: 20.05a + +n1biv: + common: + description: >- + A regional lymph node TNM finding indicating that the metastases to the lymph + nodes are more than 20 mm. + termDef: + term: >- + N1bIV Stage Finding + source: NCIt + cde_id: C95937 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95937" + term_id: C95937 + term_version: 20.05a + +n1c: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases usually in + a limited number of regional lymph nodes. The definition of N1c TNM finding + depends on the specific type of cancer that it refers to; for example, for breast + cancer it refers to metastases in 1 to 3 axillary lymph nodes and in internal + mammary lymph nodes with micrometastases or macrometastases detected by sentinel + lymph node biopsy but not clinically detected; for colorectal cancer it refers + to tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic + or perirectal tissues without regional lymph node metastasis. + termDef: + term: >- + N1c Stage Finding + source: NCIt + cde_id: C48709 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48709" + term_id: C48709 + term_version: 20.05a + +n1mi: + common: + description: >- + A regional lymph node TNM finding indicating the presence of micrometastases + (greater than 0.2 mm and/or more than 200 cells, but none greater than 2.0 mm). + termDef: + term: >- + N1mi Stage Finding + source: NCIt + cde_id: C95955 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95955" + term_id: C95955 + term_version: 20.05a + +n2: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in several + regional lymph nodes. The definition of N2 TNM finding depends on the specific + type of cancer that it refers to; for example, for breast cancer it refers to + metastases in 4-9 axillary lymph nodes; for cutaneous melanoma it refers to + metastases in 2-3 regional lymph nodes; for colorectal cancer it refers to metastases + in 4 or more regional lymph nodes; and for bladder cancer it refers to metastases + in multiple regional lymph nodes in the true pelvis. + termDef: + term: >- + N2 Stage Finding + source: NCIt + cde_id: C48786 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48786" + term_id: C48786 + term_version: 20.05a + +n2a: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in several + regional lymph nodes. The definition of N2a TNM finding depends on the specific + type of cancer that it refers to; for example, for breast cancer it refers to + metastases in 4 to 9 axillary lymph nodes (at least 1 tumor deposit greater + than 2.0 mm); for cutaneous melanoma it refers to micrometastases in 2-3 regional + lymph nodes; for colorectal cancer it refers to metastases in 4-6 regional lymph + nodes. + termDef: + term: >- + N2a Stage Finding + source: NCIt + cde_id: C48711 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48711" + term_id: C48711 + term_version: 20.05a + +n2b: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in several + regional lymph nodes. The definition of N2b TNM finding depends on the specific + type of cancer that it refers to; for example, for breast cancer it refers to + metastases only in clinically detected ipsilateral internal mammary nodes and + in the absence of clinically evident level I, II axillary lymph node metastases; + for cutaneous melanoma it refers to macrometastases in 2-3 regional lymph nodes; + for colorectal cancer it refers to metastases in seven or more regional lymph + nodes. + termDef: + term: >- + N2b Stage Finding + source: NCIt + cde_id: C48712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48712" + term_id: C48712 + term_version: 20.05a + +n2c: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in several + regional lymph nodes. The definition of N2c TNM finding depends on the specific + type of cancer that it refers to; for example, for cutaneous melanoma it refers + to intralymphatic metastases (in transit or satellite metastases) without metastatic + nodes; for lip and oral cavity cancer it refers to metastases in bilateral or + contralateral lymph nodes, none more than 6 cm in greatest dimension. + termDef: + term: >- + N2c Stage Finding + source: NCIt + cde_id: C48713 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48713" + term_id: C48713 + term_version: 20.05a + +n3: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in multiple + lymph nodes. The definition of N3 TNM finding depends on the specific type of + cancer that it refers to; for example, for breast cancer it refers to metastases + in 10 or more axillary lymph nodes; for cutaneous melanoma it refers to metastases + in 4 or more regional lymph nodes; for gastric cancer it refers to metastases + in 7 or more regional lymph nodes; and for bladder cancer it refers to metastases + in common iliac lymph nodes. + termDef: + term: >- + N3 Stage Finding + source: NCIt + cde_id: C48714 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48714" + term_id: C48714 + term_version: 20.05a + +n3a: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in multiple + lymph nodes. The definition of N3a TNM finding depends on the specific type + of cancer that it refers to; for example, for breast cancer it refers to metastases + in 10 or more axillary lymph nodes (at least one tumor deposit greater than + 2.0 mm) or metastases to the infraclavicular (level III axillary) lymph nodes; + for gastric cancer it refers to metastases in 7-15 regional lymph nodes; for + nasopharyngeal cancer it refers to metastases to one or more lymph nodes greater + than 6 cm in greatest dimension. + termDef: + term: >- + N3a Stage Finding + source: NCIt + cde_id: C48715 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48715" + term_id: C48715 + term_version: 20.05a + +n3b: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in multiple + lymph nodes. The definition of N3b TNM finding depends on the specific type + of cancer that it refers to; for example, for breast cancer it refers to metastases + in clinically detected ipsilateral internal mammary lymph nodes in the presence + of one or more positive axillary lymph nodes, or in more than 3 axillary lymph + nodes and in internal mammary lymph nodes with micrometastases or macrometastases + detected by sentinel lymph node biopsy but not clinically detected; for gastric + cancer it refers to metastases in sixteen or more regional lymph nodes; for + nasopharyngeal cancer it refers to extension to the supraclavicular fossa. + termDef: + term: >- + N3b Stage Finding + source: NCIt + cde_id: C48716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48716" + term_id: C48716 + term_version: 20.05a + +n3c: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in multiple + lymph nodes. The definition of N3c TNM finding depends on the specific type + of cancer that it refers to; for example, for breast cancer it refers to metastases + in ipsilateral supraclavicular lymph nodes. + termDef: + term: >- + N3c Stage Finding + source: NCIt + cde_id: C48717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48717" + term_id: C48717 + term_version: 20.05a + +n4: + common: + description: >- + A general term that refers to a TNM finding of cancer metastases in multiple + lymph nodes. The definition of N4 TNM finding depends on the specific type of + cancer that it refers to; for example, for ocular adnexal lymphoma it refers + to metastases to central lymph nodes. + termDef: + term: >- + N4 Stage Finding + source: NCIt + cde_id: C96026 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96026" + term_id: C96026 + term_version: 20.05a + +nab2: + common: + description: >- + This gene plays a role in the repression of gene transcription. + termDef: + term: >- + NAB2 Gene + source: NCIt + cde_id: C122903 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122903" + term_id: C122903 + term_version: 20.10d + +naca: + common: + description: >- + This gene plays a role in protein sorting. + termDef: + term: >- + NACA Gene + source: NCIt + cde_id: C97653 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97653" + term_id: C97653 + term_version: 20.10d + +nagrestipen: + common: + description: >- + A recombinant form of a human macrophage inflammatory protein-1 alpha (MIP1-alpha) + with a substitution of aspartate to alanine at position 26, with potential immunomodulating + and radiotherapy potentiating activity. Intravenous administration of nagrestipen + after local tumor irradiation enhances the anti-tumor effect of ionizing radiation + at the irradiated site as well as the antitumor effect at non-irradiated tumor + sites (known as the abscopal effect). The abscopal effect appears to be attributed + to this agent's ability to recruit and activate leukocytes, such as monocytes, + dendritic cells, natural killer cells and T lymphocytes, thereby initiating + an anti-tumor immune response against cancer cells. MIP1-alpha, also known as + chemokine (C-C motif) ligand 3, is a ligand for the chemokine receptors CCR1, + CCR4 and CCR5 that are involved in immune and inflammatory responses. + termDef: + term: >- + Nagrestipen + source: NCIt + cde_id: C98294 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98294" + term_id: C98294 + term_version: 20.10d + +namibia: + common: + description: >- + A country in southwestern Africa, bordering the South Atlantic Ocean, between + Angola and South Africa. + termDef: + term: >- + Namibia + source: NCIt + cde_id: C16891 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16891" + term_id: C16891 + term_version: 19.12e + +naratuximab_emtansine: + common: + description: >- + An immunoconjugate that consists of a humanized IgG1 antibody K7153A against + the cell-surface antigen CD37 and covalently linked via the uncleavable, maleimide-derived + thioether-based linker SMCC to the maytansinoid DM1, with potential pro-apoptotic + and cytotoxic activities. Upon administration of naratuximab emtansine, the + antibody moiety of IMGN529 binds to CD37 on tumor B-cells and induces an antibody-dependent + cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), + thereby showing pro-apoptotic activity. In addition, after the internalization + of this agent and lysosomal degradation, the DM1 moiety binds to tubulin and + inhibits tubulin polymerization and microtubule assembly, resulting in a disruption + of microtubule activity and cell division, and eventually causing cell death + in CD37-positive B-cells. CD37, a transmembrane glycoprotein, is overexpressed + in B-cell malignancies. Compared to reducible, cleavable linkers, the non-reducible + SMCC linker shows increased stability in plasma. + termDef: + term: >- + Naratuximab Emtansine + source: NCIt + cde_id: C100101 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C100101" + term_id: C100101 + term_version: 20.10d + +nasal_cavity: + common: + description: >- + The proximal portion of the respiratory passages on either side of the nasal + septum lying between the floor of the cranium and the roof of the mouth and + extending from the face to the pharynx. The nasal cavity is lined with ciliated + mucosa, extending from the nares to the pharynx. + termDef: + term: >- + Nasal Cavity + source: NCIt + cde_id: C12424 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12424" + term_id: C12424 + term_version: 20.05a + +nasopharynx_nos: + common: + description: >- + The part of the pharynx in the back of the throat, at and above the soft palate. + The nasopharynx is continuous with the nasal passages. + termDef: + term: >- + Nasopharynx + source: NCIt + cde_id: C12423 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12423" + term_id: C12423 + term_version: 20.05a + +native_hawaiian_or_other_pacific_islander: + common: + description: >- + A person having origins in any of the original peoples of Hawaii, Guam, Samoa, + or other Pacific Islands. (OMB) + termDef: + term: >- + Native Hawaiian or Other Pacific Islander + source: NCIt + cde_id: C41219 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C41219" + term_id: C41219 + term_version: 19.12e + +natural_brother: + common: + description: >- + A male who shares with his sibling the genetic makeup inherited from one or + both of their shared biological parents. + termDef: + term: >- + Biological Brother + source: NCIt + cde_id: C96570 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96570" + term_id: C96570 + term_version: 19.12e + +natural_child: + common: + description: >- + A son or daughter with genetic makeup inherited from the parent. + termDef: + term: >- + Biological Child + source: NCIt + cde_id: C100807 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C100807" + term_id: C100807 + term_version: 19.12e + +natural_daughter: + common: + description: >- + A female human offspring. + termDef: + term: >- + Daughter + source: NCIt + cde_id: C25165 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25165" + term_id: C25165 + term_version: 19.12e + +natural_father: + common: + description: >- + A male who contributes to the genetic makeup of his offspring through the fertilization + of an ovum by his sperm. + termDef: + term: >- + Biological Father + source: NCIt + cde_id: C96572 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96572" + term_id: C96572 + term_version: 19.12e + +natural_grandchild: + common: + description: >- + A biological child of an individual's biological child. + termDef: + term: >- + Biological Grandchild + source: NCIt + cde_id: C100805 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C100805" + term_id: C100805 + term_version: 19.12e + +natural_grandfather: + common: + description: >- + A male relative who is the biological father of either the biological mother + or the biological father. + termDef: + term: >- + Biological Grandfather + source: NCIt + cde_id: C96573 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96573" + term_id: C96573 + term_version: 19.12e + +natural_grandmother: + common: + description: >- + A female relative who is the biological mother of either the biological mother + or the biological father. + termDef: + term: >- + Biological Grandmother + source: NCIt + cde_id: C96574 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96574" + term_id: C96574 + term_version: 19.12e + +natural_grandparent: + common: + description: >- + A biological parent of the biological father or biological mother. + termDef: + term: >- + Biological Grandparent + source: NCIt + cde_id: C100806 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C100806" + term_id: C100806 + term_version: 19.12e + +natural_mother: + common: + description: >- + A female who contributes to the genetic makeup of her offspring from the fertilization + of her ovum. + termDef: + term: >- + Biological Mother + source: NCIt + cde_id: C96580 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96580" + term_id: C96580 + term_version: 19.12e + +natural_parent: + common: + description: >- + The male who supplied the sperm or the female who supplied the egg which resulted + in one's conception. + termDef: + term: >- + Biological Parent + source: NCIt + cde_id: C166114 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166114" + term_id: C166114 + term_version: 19.12e + +natural_sibling: + common: + description: >- + A person's brother or sister with whom they share a genetic makeup inherited + from one or both of their shared biological parents. + termDef: + term: >- + Biological Sibling + source: NCIt + cde_id: C100809 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C100809" + term_id: C100809 + term_version: 19.12e + +natural_sister: + common: + description: >- + A female who shares with her sibling the genetic makeup inherited from one or + both of their shared biological parents. + termDef: + term: >- + Biological Sister + source: NCIt + cde_id: C96586 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96586" + term_id: C96586 + term_version: 19.12e + +natural_son: + common: + description: >- + A male progeny with genetic makeup inherited from the parent. + termDef: + term: >- + Biological Son + source: NCIt + cde_id: C150888 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150888" + term_id: C150888 + term_version: 19.12e + +nauru: + common: + description: >- + A country in Oceania, occupying an island in the South Pacific Ocean, south + of the Marshall Islands. + termDef: + term: >- + Nauru + source: NCIt + cde_id: C16896 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16896" + term_id: C16896 + term_version: 19.12e + +navicixizumab: + common: + description: >- + A bispecific monoclonal antibody directed against both the Notch ligand delta-like + 4 (DLL4) and the human tyrosine kinase vascular endothelial growth factor (VEGF), + with potential anti-angiogenic and antineoplastic activities. The anti-DLL4 + moiety of navicixizumab specifically binds to DLL4, prevents its interaction + with Notch receptors, and inhibits Notch-mediated signaling and gene transcription, + which may both block tumor angiogenesis and inhibit tumor cell growth. The anti-VEGF + moiety binds to VEGF and prevents the binding of VEGF to its receptor, which + blocks VEGF-mediated signaling and further inhibits the growth and maintenance + of tumor blood vessels. The expression of DLL4 is highly restricted to the vascular + endothelium; DLL4/Notch signaling is required for the development of functional + tumor blood vessels. The expression of the pro-angiogenic growth factor VEGF + is associated with tumor angiogenesis and tumor cell proliferation and invasion. + termDef: + term: >- + Navicixizumab + source: NCIt + cde_id: C119620 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119620" + term_id: C119620 + term_version: 20.10d + +nbea: + common: + description: >- + This gene plays a role in membrane-targeting of protein kinase A. + termDef: + term: >- + NBEA Gene + source: NCIt + cde_id: C143075 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143075" + term_id: C143075 + term_version: 20.10d + +nbn: + common: + description: >- + This gene plays a role in DNA repair and cell cycle checkpoints. + termDef: + term: >- + NBN Gene + source: NCIt + cde_id: C21178 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21178" + term_id: C21178 + term_version: 20.10d + +nckipsd: + common: + description: >- + This gene plays a role in stress fiber formation. + termDef: + term: >- + NCKIPSD Gene + source: NCIt + cde_id: C97433 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97433" + term_id: C97433 + term_version: 20.10d + +ncoa1: + common: + description: >- + This gene plays a role in regulation of transcription. + termDef: + term: >- + NCOA1 Gene + source: NCIt + cde_id: C20695 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20695" + term_id: C20695 + term_version: 20.10d + +ncoa2: + common: + description: >- + This gene is involved in regulation of transcription. It also plays a role in + myogenic differentiation. + termDef: + term: >- + NCOA2 Gene + source: NCIt + cde_id: C20697 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20697" + term_id: C20697 + term_version: 20.10d + +ncoa4: + common: + description: >- + This gene is involved in the transcriptional activation of target genes. + termDef: + term: >- + NCOA4 Gene + source: NCIt + cde_id: C18381 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18381" + term_id: C18381 + term_version: 20.10d + +ncor1: + common: + description: >- + This gene is involved in chromatin remodeling and repression of transcription. + termDef: + term: >- + NCOR1 Gene + source: NCIt + cde_id: C28640 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28640" + term_id: C28640 + term_version: 20.10d + +ncor2: + common: + description: >- + This gene plays a role in repression of transcription. It is also involved in + chromatin remodeling. + termDef: + term: >- + NCOR2 Gene + source: NCIt + cde_id: C28633 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28633" + term_id: C28633 + term_version: 20.10d + +ndihydrogalactochitosan: + common: + description: >- + A carbohyrate polymer in which galactose molecules are attached to the amino + groups of the glucosamine polymer chitosan, with potential imunostimulating + activity. After a tumor ablation and upon intratumoral injection directly into + the location of the ablated tumor, N-dihydrogalactochitosan may trigger a tumor-specific + systemic immune response when exposed to tumor-associated neoantigens that are + liberated by tumor ablation. This may kill tumor cells. + termDef: + term: >- + N-dihydrogalactochitosan + source: NCIt + cde_id: C173438 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173438" + term_id: C173438 + term_version: 20.10d + +ndrg1: + common: + description: >- + This gene plays a role in cellular stress responses. It is also involved in + both cell growth and differentiation. + termDef: + term: >- + NDRG1 Gene + source: NCIt + cde_id: C24625 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24625" + term_id: C24625 + term_version: 20.10d + +near_diploid: + common: + description: >- + A chromosomal abnormality in which the total chromosome number is slightly more + (hyperdiploid) or slightly less (hypodiploid) than the normal diploid number. + termDef: + term: >- + Near Diploidy + source: NCIt + cde_id: C165228 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165228" + term_id: C165228 + term_version: 20.10d + +neck: + common: + description: >- + The region that connects the head to the rest of the body. + termDef: + term: >- + Neck + source: NCIt + cde_id: C13063 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13063" + term_id: C13063 + term_version: 20.10d + +negative: + common: + description: >- + A finding of normality following an examination or investigation looking for + the presence of a microorganism, disease, or condition. + termDef: + term: >- + Negative Finding + source: NCIt + cde_id: C38757 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38757" + term_id: C38757 + term_version: 20.10d + +negative_no_dysplasia: + common: + description: >- + An indication that signs of dysplasia were not found in a sample. + termDef: + term: >- + Dysplasia Negative + source: NCIt + cde_id: C164040 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164040" + term_id: C164040 + term_version: 20.05a + +neoplasm_benign: + common: + description: >- + A neoplasm which is characterized by the absence of morphologic features associated + with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic + rate). Benign neoplasms remain confined to the original site of growth and do + not metastasize to other anatomic sites. + termDef: + term: >- + Benign Neoplasm + source: NCIt + cde_id: C3677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3677" + term_id: C3677 + term_version: 20.05a + +neoplasm_malignant: + common: + description: >- + A tumor composed of atypical neoplastic, often pleomorphic cells that invade + other tissues. Malignant neoplasms often metastasize to distant anatomic sites + and may recur after excision. The most common malignant neoplasms are carcinomas, + Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. + termDef: + term: >- + Malignant Neoplasm + source: NCIt + cde_id: C9305 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9305" + term_id: C9305 + term_version: 20.05a + +neoplasm_malignant_uncertain_whether_primary_or_metastatic: + common: + description: >- + A malignant neoplasm in which the examined tissue can not be determined with + certainty if it represents the primary site of tumor growth or tumor spread + from another anatomic site. + termDef: + term: >- + Malignant Neoplasm, Uncertain Whether Primary or Metastatic + source: NCIt + cde_id: C65153 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65153" + term_id: C65153 + term_version: 20.05a + +neoplasm_metastatic: + common: + description: >- + A tumor that has spread from its original (primary) site of growth to another + site, close to or distant from the primary site. Metastasis is characteristic + of advanced malignancies, but in rare instances can be seen in neoplasms lacking + malignant morphology. + termDef: + term: >- + Metastatic Neoplasm + source: NCIt + cde_id: C3261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3261" + term_id: C3261 + term_version: 20.05a + +neoplasm_nos: + common: + description: >- + A benign or malignant tissue growth resulting from uncontrolled cell proliferation. + Benign neoplastic cells resemble normal cells without exhibiting significant + cytologic atypia, while malignant cells exhibit overt signs such as dysplastic + features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. + Representative examples of benign neoplasms include papillomas, cystadenomas, + and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and + leukemias. + termDef: + term: >- + Neoplasm + source: NCIt + cde_id: C3262 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3262" + term_id: C3262 + term_version: 20.05a + +neoplasm_secondary: + common: + description: >- + A neoplasm that arises from a pre-existing lower grade lesion, or as a result + of a primary lesion that has spread to secondary sites, or due to a complication + of a cancer treatment. + termDef: + term: >- + Secondary Neoplasm + source: NCIt + cde_id: C36255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36255" + term_id: C36255 + term_version: 20.05a + +neoplasm_uncertain_whether_benign_or_malignant: + common: + description: >- + A neoplasm which, on morphologic grounds, can not be classified with certainty + as benign or malignant. + termDef: + term: >- + Neoplasm, Uncertain Whether Benign or Malignant + source: NCIt + cde_id: C65157 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65157" + term_id: C65157 + term_version: 20.05a + +nepal: + common: + description: >- + A country in southern Asia, between China and India, west of Bhutan. + termDef: + term: >- + Nepal + source: NCIt + cde_id: C16901 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16901" + term_id: C16901 + term_version: 19.12e + +nephew: + common: + description: >- + A son of your brother or sister. + termDef: + term: >- + Nephew + source: NCIt + cde_id: C71409 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71409" + term_id: C71409 + term_version: 19.12e + +nephroblastoma_nos: + common: + description: >- + An embryonal pediatric tumor of the kidney which may also be seen rarely in + adults. The peak incidence of Wilms tumor is between the second and fifth year + of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, + stromal, and epithelial). The most common sites of metastasis include the regional + lymph nodes, lungs, and liver. + termDef: + term: >- + Kidney Wilms Tumor + source: NCIt + cde_id: C40407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40407" + term_id: C40407 + term_version: 20.05a + +nephrogenic_adenofibroma: + common: + description: >- + A benign, solitary, and partially cystic neoplasm arising from the kidney. It + occurs in children and adults. Presenting symptoms include hematuria and polycythemia. + It is characterized by the presence of epithelial nodules embedded in a stroma + containing spindle cells. + termDef: + term: >- + Metanephric Adenofibroma + source: NCIt + cde_id: C39812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39812" + term_id: C39812 + term_version: 20.05a + +nephroma_nos: + common: + description: >- + An embryonal pediatric tumor of the kidney which may also be seen rarely in + adults. The peak incidence of Wilms tumor is between the second and fifth year + of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, + stromal, and epithelial). The most common sites of metastasis include the regional + lymph nodes, lungs, and liver. + termDef: + term: >- + Kidney Wilms Tumor + source: NCIt + cde_id: C40407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40407" + term_id: C40407 + term_version: 20.05a + +nerve_sheath_myxoma: + common: + description: >- + A benign neoplasm arising from nerve sheaths. It is characterized by the presence + of a myxoid stroma. + termDef: + term: >- + Nerve Sheath Myxoma + source: NCIt + cde_id: C7018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7018" + term_id: C7018 + term_version: 20.05a + +nerve_tissue: + common: + description: >- + The tissue that generates and conducts electrical signals in the body. It contains + the neurons. + termDef: + term: >- + Nerve Tissue + source: NCIt + cde_id: C13052 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13052" + term_id: C13052 + term_version: 20.10d + +nervous_system_nos: + common: + description: >- + The entire nerve apparatus, composed of a central part, the brain and spinal + cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, + and plexuses. + termDef: + term: >- + Nervous System + source: NCIt + cde_id: C12755 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12755" + term_id: C12755 + term_version: 20.05a + +nesidioblastoma: + common: + description: >- + A benign endocrine neoplasm arising from the pancreas. It is separated from + the normal pancreatic tissues by a thin collagenous capsule. It may secrete + a hormone (e.g. insulin, gastrin) or it may be non-functional. + termDef: + term: >- + Islet Cell Adenoma + source: NCIt + cde_id: C65184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65184" + term_id: C65184 + term_version: 20.05a + +nested_urothelial_carcinoma: + common: + description: >- + A variant of infiltrating bladder urothelial carcinoma. It is characterized + by a nested growth pattern. + termDef: + term: >- + Infiltrating Bladder Urothelial Carcinoma, Nested Variant + source: NCIt + cde_id: C39819 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39819" + term_id: C39819 + term_version: 20.05a + +netherlands: + common: + description: >- + A country in western Europe, bordering the North Sea, between Belgium and Germany. + termDef: + term: >- + Netherlands + source: NCIt + cde_id: C16903 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16903" + term_id: C16903 + term_version: 19.12e + +neurilemoma_malignant: + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +neurilemoma_nos: + common: + description: >- + A benign, usually encapsulated slow growing tumor composed of Schwann cells. It + affects peripheral and cranial nerves. It recurs infrequently and only rare + cases associated with malignant transformation have been reported. + termDef: + term: >- + Schwannoma + source: NCIt + cde_id: C3269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3269" + term_id: C3269 + term_version: 20.05a + +neurilemosarcoma: + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +neurinoma: + common: + description: >- + A benign, usually encapsulated slow growing tumor composed of Schwann cells. It + affects peripheral and cranial nerves. It recurs infrequently and only rare + cases associated with malignant transformation have been reported. + termDef: + term: >- + Schwannoma + source: NCIt + cde_id: C3269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3269" + term_id: C3269 + term_version: 20.05a + +neurinomatosis: + common: + description: >- + A rare genetic disorder characterized by the presence of multiple schwannomas. + termDef: + term: >- + Schwannomatosis + source: NCIt + cde_id: C6557 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6557" + term_id: C6557 + term_version: 20.05a + +neuroastrocytoma: + common: + description: >- + A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, + mature ganglion cells and neoplastic glial cells. Some gangliogliomas show anaplastic + features in their glial component and are considered to be WHO grade III. Rare + cases of newly diagnosed gangliogliomas with grade IV (glioblastoma) changes + in the glial component have also been reported. (Adapted from WHO) + termDef: + term: >- + Ganglioglioma + source: NCIt + cde_id: C3788 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3788" + term_id: C3788 + term_version: 20.05a + +neuroblastoma: + common: + description: >- + A neuroblastic tumor characterized by the presence of neuroblastic cells, the + absence of ganglion cells, and the absence of a prominent Schwannian stroma + formation. + termDef: + term: >- + Neuroblastoma + source: NCIt + cde_id: C3270 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3270" + term_id: C3270 + term_version: 19.12e + +neuroblastoma_nos: + common: + description: >- + A neuroblastic tumor characterized by the presence of neuroblastic cells, the + absence of ganglion cells, and the absence of a prominent Schwannian stroma + formation. + termDef: + term: >- + Neuroblastoma + source: NCIt + cde_id: C3270 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3270" + term_id: C3270 + term_version: 20.05a + +neurocytoma: + common: + description: >- + An intraventricular neuronal neoplasm composed of uniform round cells with neuronal + differentiation. It is typically located in the lateral ventricles in the region + of the foramen of Monro. It generally affects young adults and has a favorable + prognosis. (Adapted from WHO) + termDef: + term: >- + Central Neurocytoma + source: NCIt + cde_id: C3791 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3791" + term_id: C3791 + term_version: 20.05a + +neuroectodermal_tumor_nos: + common: + description: >- + A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm + constitutes the portion of the ectoderm of the early embryo that gives rise + to the central and peripheral nervous systems and includes some glial cell precursors. + termDef: + term: >- + Primitive Neuroectodermal Tumor + source: NCIt + cde_id: C3716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3716" + term_id: C3716 + term_version: 20.05a + +neuroendocrine_carcinoma_low_grade: + common: + description: >- + Grade I Neuroendocrine Carcinoma + termDef: + term: >- + Grade I Neuroendocrine Carcinoma + source: NCIt + cde_id: C35727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35727" + term_id: C35727 + term_version: 20.05a + +neuroendocrine_carcinoma_moderately_differentiated: + common: + description: >- + Grade II Neuroendocrine Carcinoma + termDef: + term: >- + Grade II Neuroendocrine Carcinoma + source: NCIt + cde_id: C35725 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35725" + term_id: C35725 + term_version: 20.05a + +neuroendocrine_carcinoma_nos: + common: + description: >- + A malignant neuroendocrine neoplasm composed of cells containing secretory granules + that stain positive for NSE and chromogranin. The neoplastic cells are often + round and form clusters or trabecular sheets. Representative examples are small + cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma. + termDef: + term: >- + Neuroendocrine Carcinoma + source: NCIt + cde_id: C3773 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3773" + term_id: C3773 + term_version: 20.05a + +neuroendocrine_carcinoma_poorly_differentiated: + common: + description: >- + A neoplastic lesion with neuroendocrine differentiation and poorly differentiated + histological features. + termDef: + term: >- + Poorly Differentiated Neuroendocrine Lesion + source: NCIt + cde_id: C155863 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155863" + term_id: C155863 + term_version: 20.05a + +neuroendocrine_carcinoma_welldifferentiated: + common: + description: >- + Grade I Neuroendocrine Carcinoma + termDef: + term: >- + Grade I Neuroendocrine Carcinoma + source: NCIt + cde_id: C35727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35727" + term_id: C35727 + term_version: 20.05a + +neuroendocrine_tumor_well_differentiated: + common: + description: >- + A neoplastic lesion with neuroendocrine differentiation and well differentiated + histological features. + termDef: + term: >- + Well Differentiated Neuroendocrine Lesion + source: NCIt + cde_id: C155861 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155861" + term_id: C155861 + term_version: 20.05a + +neuroepithelioma_nos: + common: + description: >- + A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm + constitutes the portion of the ectoderm of the early embryo that gives rise + to the central and peripheral nervous systems and includes some glial cell precursors. + termDef: + term: >- + Primitive Neuroectodermal Tumor + source: NCIt + cde_id: C3716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3716" + term_id: C3716 + term_version: 20.05a + +neurofibroma_nos: + common: + description: >- + An intraneural or extraneural neoplasm arising from nerve tissues and neural + sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It + usually presents as a localized cutaneous lesion and less often as a circumscribed + peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple + masses. Neurofibromas which arise from major nerves and plexiform neurofibromas + are precursor lesions to malignant peripheral nerve sheath tumors. + termDef: + term: >- + Neurofibroma + source: NCIt + cde_id: C3272 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3272" + term_id: C3272 + term_version: 20.05a + +neurofibromatosis_nos: + common: + description: >- + An autosomal dominant hereditary neoplastic syndrome. Two distinct clinicopathological + entities are recognized: neurofibromatosis type 1 and neurofibromatosis type + 2. Neurofibromatosis type 1 is associated with the presence of cafe-au-lait + cutaneous lesions, multiple neurofibromas, malignant peripheral nerve sheath + tumors, optic nerve gliomas, and bone lesions. Neurofibromatosis type 2 is associated + with the presence of schwannomas, meningiomas, and gliomas. + termDef: + term: >- + Neurofibromatosis + source: NCIt + cde_id: C6727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6727" + term_id: C6727 + term_version: 20.05a + +neurofibrosarcoma: + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +neurogenic_sarcoma: + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +neurolipocytoma: + common: + description: >- + A rare, WHO grade II cerebellar neoplasm which shows consistent neuronal, variable + astrocytic and focal lipomatous differentiation. It occurs in adults, has a + low proliferative potential and usually has a favorable prognosis. (Adapted + from WHO) + termDef: + term: >- + Cerebellar Liponeurocytoma + source: NCIt + cde_id: C6905 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6905" + term_id: C6905 + term_version: 20.05a + +neuroma_nos: + common: + description: >- + A tumor that grows from a nerve or is composed of nerve cells and nerve fibers. + termDef: + term: >- + Neuroma + source: NCIt + cde_id: C3275 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3275" + term_id: C3275 + term_version: 20.05a + +neuronevus: + common: + description: >- + An intradermal nevus characterized by the presence of nests of atrophic nevus + cells which are hyalinized and resemble nerve bundles. + termDef: + term: >- + Neuronevus + source: NCIt + cde_id: C4229 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4229" + term_id: C4229 + term_version: 20.05a + +neurosarcoma: + common: + description: >- + An uncommon, highly aggressive malignant tumor, arising from the peripheral + nerves and affecting mostly adults in their third to sixth decades of life. It + usually occurs in medium-sized and large nerves of the buttock, thigh, upper + arm, or the paraspinal region. It may be associated with neurofibromatosis + 1 (NF1). + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor + source: NCIt + cde_id: C3798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3798" + term_id: C3798 + term_version: 20.05a + +neurothekeoma: + common: + description: >- + A benign neoplasm arising from nerve sheaths. It is characterized by the presence + of a myxoid stroma. + termDef: + term: >- + Nerve Sheath Myxoma + source: NCIt + cde_id: C7018 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7018" + term_id: C7018 + term_version: 20.05a + +neutrophil_bands: + common: + description: >- + The determination of the number of band neutrophils in a blood sample. + termDef: + term: >- + Neutrophil Band Form Count + source: NCIt + cde_id: C64830 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64830" + term_id: C64830 + term_version: 20.10d + +nevus_nos: + common: + description: >- + A neoplasm composed of melanocytes that usually appears as a dark spot on the + skin. + termDef: + term: >- + Melanocytic Nevus + source: NCIt + cde_id: C7570 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7570" + term_id: C7570 + term_version: 20.05a + +new_caledonia: + common: + description: >- + A country in the Pacific, comprised of islands in the South Pacific Ocean, east + of Australia. + termDef: + term: >- + New Caledonia + source: NCIt + cde_id: C16913 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16913" + term_id: C16913 + term_version: 19.12e + +new_zealand: + common: + description: >- + A country in the Pacific, comprised of islands in the South Pacific Ocean, southeast + of Australia. + termDef: + term: >- + New Zealand + source: NCIt + cde_id: C16914 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16914" + term_id: C16914 + term_version: 19.12e + +nf1: + common: + description: >- + This gene plays a role in signal transduction and cytoskeletal remodeling. + termDef: + term: >- + NF1 Gene + source: NCIt + cde_id: C17424 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17424" + term_id: C17424 + term_version: 20.10d + +nf2: + common: + description: >- + This gene plays a role in cell adhesion and cytoskeletal remodeling. It is also + involved in suppression of cell growth. + termDef: + term: >- + NF2 Gene + source: NCIt + cde_id: C17425 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17425" + term_id: C17425 + term_version: 20.10d + +nfatc2: + common: + description: >- + This gene is involved in cytokine gene transcription. + termDef: + term: >- + NFATC2 Gene + source: NCIt + cde_id: C93138 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93138" + term_id: C93138 + term_version: 20.10d + +nfe2l2: + common: + description: >- + This gene plays a role in transcriptional regulation. + termDef: + term: >- + NFE2L2 Gene + source: NCIt + cde_id: C54237 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54237" + term_id: C54237 + term_version: 20.10d + +nfib: + common: + description: >- + This gene plays a role in transcriptional regulation and mediates DNA-binding + interactions. + termDef: + term: >- + NFIB Gene + source: NCIt + cde_id: C38401 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38401" + term_id: C38401 + term_version: 20.10d + +nfkb2: + common: + description: >- + This gene plays a role in transcriptional regulation, signal transduction and + inflammatory responses. + termDef: + term: >- + NFKB2 Gene + source: NCIt + cde_id: C18404 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18404" + term_id: C18404 + term_version: 20.10d + +nfkbie: + common: + description: >- + This gene plays a role in signal transduction and regulation of transcription. + It is involved in the immune response. + termDef: + term: >- + NFKBIE Gene + source: NCIt + cde_id: C38396 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38396" + term_id: C38396 + term_version: 20.10d + +nicaragua: + common: + description: >- + A country in Central America, bordering both the Caribbean Sea and the North + Pacific Ocean, between Costa Rica and Honduras. + termDef: + term: >- + Nicaragua + source: NCIt + cde_id: C16915 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16915" + term_id: C16915 + term_version: 19.12e + +niece: + common: + description: >- + A daughter of your brother or sister. + termDef: + term: >- + Niece + source: NCIt + cde_id: C71408 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71408" + term_id: C71408 + term_version: 19.12e + +niece_second_degree_relative: + common: + description: >- + A daughter of one's biological sibling. + termDef: + term: >- + Biological Niece + source: NCIt + cde_id: C166115 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166115" + term_id: C166115 + term_version: 19.12e + +niger: + common: + description: >- + A country in western Africa, southeast of Algeria and north of Nigeria. + termDef: + term: >- + Niger + source: NCIt + cde_id: C16916 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16916" + term_id: C16916 + term_version: 19.12e + +nigeria: + common: + description: >- + A country in western Africa, bordering the Gulf of Guinea, between Benin and + Cameroon. + termDef: + term: >- + Nigeria + source: NCIt + cde_id: C16917 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16917" + term_id: C16917 + term_version: 19.12e + +nin: + common: + description: >- + This gene is involved in the localization of the centrosome. + termDef: + term: >- + NIN Gene + source: NCIt + cde_id: C97668 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97668" + term_id: C97668 + term_version: 20.10d + +nipple: + common: + description: >- + The pigmented protuberance on the surface of the breast through which milk is + drawn from the breast. + termDef: + term: >- + Nipple + source: NCIt + cde_id: C12299 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12299" + term_id: C12299 + term_version: 20.05a + +niue: + common: + description: >- + A country in the Pacific, occupying an island in the South Pacific Ocean, east + of Tonga and south of American Samoa. + termDef: + term: >- + Niue + source: NCIt + cde_id: C16918 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16918" + term_id: C16918 + term_version: 19.12e + +nktcell_lymphoma_nasal_and_nasaltype: + common: + description: >- + An aggressive, predominantly extranodal, mature T-cell non-Hodgkin lymphoma. + It is characterized by an often angiocentric and angiodestructive cellular infiltrate + composed of EBV positive NK/T cells. The nasal cavity is the most common site + of involvement. Patients often present with midfacial destructive lesions (lethal + midline granuloma). The disease may disseminate rapidly to various anatomic + sites including the gastrointestinal tract, skin, testis, and cervical lymph + nodes. It is also known as angiocentric T-cell lymphoma. The term "polymorphic + reticulosis" has been widely used to describe the morphologic changes seen in + this type of lymphoma. However, the latter term may also apply to lymphomatoid + granulomatosis, which is an angiocentric and angiodestructive EBV positive B-cell + lymphoproliferative disorder. + termDef: + term: >- + Nasal Type Extranodal NK/T-Cell Lymphoma + source: NCIt + cde_id: C4684 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4684" + term_id: C4684 + term_version: 20.05a + +nkx21: + common: + description: >- + This gene plays a role in thyroid gene transcription. + termDef: + term: >- + NKX2-1 Gene + source: NCIt + cde_id: C73443 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73443" + term_id: C73443 + term_version: 20.10d + +nmd_transcript_variant: + common: + description: >- + A mutation occurring in a sequence that regulates non-sense mediated mRNA decay. + termDef: + term: >- + Non-Sense Mediated Decay Mutation + source: NCIt + cde_id: C148643 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148643" + term_id: C148643 + term_version: 20.10d + +"no": + common: + description: >- + The non-affirmative response to a question. + termDef: + term: >- + No + source: NCIt + cde_id: C49487 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49487" + term_id: C49487 + term_version: 19.12e + +no_dysplasia: + common: + description: >- + An indication that signs of dysplasia were not found in a sample. + termDef: + term: >- + Dysplasia Negative + source: NCIt + cde_id: C164040 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164040" + term_id: C164040 + term_version: 20.10d + +no_metastasis: + common: + description: >- + An indication that signs of metastasis were not found in a sample. + termDef: + term: >- + Metastasis Negative + source: NCIt + cde_id: C164041 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164041" + term_id: C164041 + term_version: 20.05a + +no_metastasis_m0: + common: + description: >- + No metastasis. + termDef: + term: >- + Enneking Metastasis M0 + source: NCIt + cde_id: C147528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C147528" + term_id: C147528 + term_version: 20.05a + +no_smoke_exposure: + common: + description: >- + An indication that a subject has no history of smoke exposure from any source. + termDef: + term: >- + No Smoke Exposure + source: NCIt + cde_id: C164092 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164092" + term_id: C164092 + term_version: 19.12e + +no_vascular_invasion: + common: + description: >- + An indication that signs of vascular invasion have not been found in a sample. + termDef: + term: >- + Vascular Invasion Negative + source: NCIt + cde_id: C164046 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164046" + term_id: C164046 + term_version: 20.05a + +nodal_marginal_zone_lymphoma: + common: + description: >- + A primary nodal B-cell non-Hodgkin lymphoma which morphologically resembles + lymph nodes involved by marginal zone lymphomas of extranodal or splenic types, + but without evidence of extranodal or splenic disease. (WHO, 2001) + termDef: + term: >- + Nodal Marginal Zone Lymphoma + source: NCIt + cde_id: C8863 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8863" + term_id: C8863 + term_version: 20.05a + +nodular_hidradenoma: + common: + description: >- + A benign epithelial neoplasm arising from the sweat glands. It presents as a + nodular lesion usually in the scalp, trunk, and proximal extremities. It is + characterized by a nodular growth pattern. Complete excision is curative. + termDef: + term: >- + Nodular Hidradenoma + source: NCIt + cde_id: C7568 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7568" + term_id: C7568 + term_version: 20.05a + +nodular_melanoma: + common: + description: >- + An aggressive form of melanoma, frequently metastasizing to the lymph nodes. It + presents as a papular or nodular raised skin lesion. It comprises approximately + 10-15% of melanomas. Morphologically, it often displays an epithelioid appearance. + termDef: + term: >- + Cutaneous Nodular Melanoma + source: NCIt + cde_id: C4225 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4225" + term_id: C4225 + term_version: 20.05a + +nogapendekin_alfa: + common: + description: >- + A fusion protein complex composed of a mutated form of the cytokine interleukin + (IL)-15 (IL-15N72D) and a soluble, dimeric IL-15 receptor alpha (IL-15Ra) Fc + fusion protein (IL-15Ra-Fc) (IL-15N72D/IL-15Ra-Fc), with potential antineoplastic + activity. Upon administration, superagonist interleukin-15:interleukin-15 receptor + alphaSu/Fc fusion complex N-803 binds to the IL-2/IL-15 receptor beta-common + gamma chain (IL-2Rbetagamma) receptor on natural killer (NK) and CD8+ T lymphocytes, + which activates and increases the levels of NK cells and memory CD8+(CD44high) + T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma + (IFN-g), which further potentiates the immune response against tumor cells. + This may increase tumor cell killing and decrease tumor cell proliferation. + IL-15 regulates CD8+ T and NK cell development, activation and proliferation. + By coupling IL-15 to IL15Ra-Fc, this agent has a prolonged drug half-life and + shows an increased ability to bind IL-2Rbetagamma, which enhances its immune + stimulatory activity as compared to IL-15 alone. + termDef: + term: >- + Nogapendekin Alfa + source: NCIt + cde_id: C107503 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107503" + term_id: C107503 + term_version: 20.10d + +nonchromaffin_paraganglioma_malignant: + common: + description: >- + An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic + sites. Common sites of metastasis include the lymph nodes, lungs, bones, and + liver. + termDef: + term: >- + Malignant Extra-Adrenal Paraganglioma + source: NCIt + cde_id: C4219 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4219" + term_id: C4219 + term_version: 20.05a + +nonclonal: + common: + description: >- + An indication that the cells in a sample did not arise from a single progenitor + cell. + termDef: + term: >- + Nonclonal Cellular Population Present + source: NCIt + cde_id: C172229 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172229" + term_id: C172229 + term_version: 20.10d + +noncoding_transcript_exon_variant: + common: + description: >- + A change in the nucleotide sequence of an exon in a non-coding gene. + termDef: + term: >- + Non-Coding Gene Exon Mutation + source: NCIt + cde_id: C148645 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148645" + term_id: C148645 + term_version: 20.10d + +noncoding_transcript_variant: + common: + description: >- + A change in the nucleotide sequence of a non-coding gene. + termDef: + term: >- + Non-Coding Gene Mutation + source: NCIt + cde_id: C148644 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148644" + term_id: C148644 + term_version: 20.10d + +nondrinker: + common: + description: >- + An individual who does not drink at the present time. This is a heterogeneous + group comprising both lifelong teetotallers and ex-drinkers. + termDef: + term: >- + Non-Drinker + source: NCIt + cde_id: C126379 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126379" + term_id: C126379 + term_version: 19.12e + +none: + common: + description: >- + No person or thing, nobody, not any. + termDef: + term: >- + None + source: NCIt + cde_id: C41132 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C41132" + term_id: C41132 + term_version: 20.10d + +nonencapsulated_sclerosing_adenocarcinoma: + common: + description: >- + A morphologic variant of papillary carcinoma of the thyroid gland that more + often affects young patients and commonly metastasizing to the lungs. It is + characterized by a diffuse infiltration of the thyroid gland by malignant follicular + cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration. + termDef: + term: >- + Diffuse Sclerosing Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C7427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7427" + term_id: C7427 + term_version: 20.05a + +nonencapsulated_sclerosing_carcinoma: + common: + description: >- + A morphologic variant of papillary carcinoma of the thyroid gland that more + often affects young patients and commonly metastasizing to the lungs. It is + characterized by a diffuse infiltration of the thyroid gland by malignant follicular + cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration. + termDef: + term: >- + Diffuse Sclerosing Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C7427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7427" + term_id: C7427 + term_version: 20.05a + +nonencapsulated_sclerosing_tumor: + common: + description: >- + A morphologic variant of papillary carcinoma of the thyroid gland that more + often affects young patients and commonly metastasizing to the lungs. It is + characterized by a diffuse infiltration of the thyroid gland by malignant follicular + cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration. + termDef: + term: >- + Diffuse Sclerosing Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C7427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7427" + term_id: C7427 + term_version: 20.05a + +nonhodgkin_lymphoma_nos: + common: + description: >- + Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin + lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can + occur at any age, and usually presents as a localized or generalized lymphadenopathy + associated with fever and weight loss. The clinical course varies according + to the morphologic type. NHL is clinically classified as indolent, aggressive, + or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage. + termDef: + term: >- + Non-Hodgkin Lymphoma + source: NCIt + cde_id: C3211 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3211" + term_id: C3211 + term_version: 20.05a + +noninfiltrating_intracystic_carcinoma: + common: + description: >- + An intraductal breast carcinoma characterized by a papillary growth within a + large cystic duct. There is no evidence of invasion of the breast parenchyma. + termDef: + term: >- + Intracystic Papillary Breast Carcinoma + source: NCIt + cde_id: C7645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7645" + term_id: C7645 + term_version: 20.05a + +noninfiltrating_intraductal_papillary_adenocarcinoma: + common: + description: >- + A non-invasive breast adenocarcinoma located in a distended duct. It is characterized + by the presence of papillary structures with fibrovascular stalks. In the absence + of ductal carcinoma in situ or invasive carcinoma in adjacent tissues, the prognosis + is usually favorable. + termDef: + term: >- + Intraductal Papillary Breast Carcinoma + source: NCIt + cde_id: C4190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4190" + term_id: C4190 + term_version: 20.05a + +noninfiltrating_intraductal_papillary_carcinoma: + common: + description: >- + A non-invasive breast adenocarcinoma located in a distended duct. It is characterized + by the presence of papillary structures with fibrovascular stalks. In the absence + of ductal carcinoma in situ or invasive carcinoma in adjacent tissues, the prognosis + is usually favorable. + termDef: + term: >- + Intraductal Papillary Breast Carcinoma + source: NCIt + cde_id: C4190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4190" + term_id: C4190 + term_version: 20.05a + +noninvasive_efvptc: + common: + description: >- + A non-invasive neoplasm of thyroid follicular cells with a follicular growth + pattern and nuclear features of papillary thyroid carcinoma that has an extremely + low malignant potential. These tumors were formerly classified as non-invasive + encapsulated follicular variant of papillary thyroid carcinoma or well-differentiated + tumor of uncertain malignant potential. (WHO 2017) + termDef: + term: >- + Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear + Features + source: NCIt + cde_id: C126598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126598" + term_id: C126598 + term_version: 20.05a + +noninvasive_encapsulated_follicular_variant_of_papillary_thyroid_carcinoma_noninvasive_efvptc: + common: + description: >- + A non-invasive neoplasm of thyroid follicular cells with a follicular growth + pattern and nuclear features of papillary thyroid carcinoma that has an extremely + low malignant potential. These tumors were formerly classified as non-invasive + encapsulated follicular variant of papillary thyroid carcinoma or well-differentiated + tumor of uncertain malignant potential. (WHO 2017) + termDef: + term: >- + Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear + Features + source: NCIt + cde_id: C126598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126598" + term_id: C126598 + term_version: 20.05a + +noninvasive_follicular_thyroid_neoplasm_with_papillarylike_nuclear_features_niftp: + common: + description: >- + A non-invasive neoplasm of thyroid follicular cells with a follicular growth + pattern and nuclear features of papillary thyroid carcinoma that has an extremely + low malignant potential. These tumors were formerly classified as non-invasive + encapsulated follicular variant of papillary thyroid carcinoma or well-differentiated + tumor of uncertain malignant potential. (WHO 2017) + termDef: + term: >- + Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear + Features + source: NCIt + cde_id: C126598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126598" + term_id: C126598 + term_version: 20.05a + +noninvasive_ftp: + common: + description: >- + A non-invasive neoplasm of thyroid follicular cells with a follicular growth + pattern and nuclear features of papillary thyroid carcinoma that has an extremely + low malignant potential. These tumors were formerly classified as non-invasive + encapsulated follicular variant of papillary thyroid carcinoma or well-differentiated + tumor of uncertain malignant potential. (WHO 2017) + termDef: + term: >- + Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear + Features + source: NCIt + cde_id: C126598 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126598" + term_id: C126598 + term_version: 20.05a + +noninvasive_pancreatobiliary_papillary_neoplasm_with_high_grade_dysplasia: + common: + description: >- + An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized + by the presence of high grade dysplasia. + termDef: + term: >- + Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade + Dysplasia + source: NCIt + cde_id: C95915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95915" + term_id: C95915 + term_version: 20.05a + +noninvasive_pancreatobiliary_papillary_neoplasm_with_high_grade_intraepithelial_neoplasia: + common: + description: >- + An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized + by the presence of high grade dysplasia. + termDef: + term: >- + Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade + Dysplasia + source: NCIt + cde_id: C95915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95915" + term_id: C95915 + term_version: 20.05a + +noninvasive_pancreatobiliary_papillary_neoplasm_with_low_grade_dysplasia: + common: + description: >- + An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized + by the presence of low grade dysplasia. + termDef: + term: >- + Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with Low Grade Dysplasia + source: NCIt + cde_id: C95914 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95914" + term_id: C95914 + term_version: 20.05a + +noninvasive_pancreatobiliary_papillary_neoplasm_with_low_grade_intraepithelial_neoplasia: + common: + description: >- + An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized + by the presence of low grade dysplasia. + termDef: + term: >- + Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with Low Grade Dysplasia + source: NCIt + cde_id: C95914 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95914" + term_id: C95914 + term_version: 20.05a + +nonkeratinizing: + common: + description: >- + Epithelial dysplasia in which there is continuum from mild dysplasia to moderate + dysplasia to severe dysplasia before the development of invasive carcinoma. + termDef: + term: >- + Non-Keratinizing Dysplasia + source: NCIt + cde_id: C161016 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C161016" + term_id: C161016 + term_version: 20.10d + +nonlymphocytic_leukemia_nos: + common: + description: >- + A clonal proliferation of myeloid cells and their precursors in the bone marrow, + peripheral blood, and spleen. When the proliferating cells are immature myeloid + cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating + myeloid cells are neutrophils, it is called chronic myelogenous leukemia. + termDef: + term: >- + Myeloid Leukemia + source: NCIt + cde_id: C3172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3172" + term_id: C3172 + term_version: 20.05a + +nonmalignant: + common: + description: >- + For neoplasms, a neoplastic process that, at the time of the pathologic diagnosis, + does not show evidence of tissue infiltration and may or may not show evidence + of atypical morphologic features (e.g., cellular atypia, formation of complex + structures, cellular pseudostratification, and increased mitotic activity). This + term encompasses benign neoplastic processes, neoplastic processes with dysplastic + features, and borderline processes. The former do not metastasize and the latter + two are associated with a future risk of stromal invasion and metastasis. For + other conditions, a process that is not seriously resistant to treatment or + dangerous to health. + termDef: + term: >- + Non-Malignant + source: NCIt + cde_id: C25588 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25588" + term_id: C25588 + term_version: 20.05a + +nono: + common: + description: >- + This gene may play a role in both transcriptional regulation and nuclear RNA + processing. + termDef: + term: >- + NONO Gene + source: NCIt + cde_id: C71419 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71419" + term_id: C71419 + term_version: 20.10d + +nonpigmented_nevus: + common: + description: >- + A benign nevus characterized by the absence of melanin pigment in the melanocytes. + termDef: + term: >- + Nonpigmented Nevus + source: NCIt + cde_id: C27095 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27095" + term_id: C27095 + term_version: 20.05a + +nonsense: + common: + description: >- + A point mutation occurring within the protein-coding region of a gene, and which + codes for a stop that can truncate the protein. + termDef: + term: >- + Nonsense Mutation + source: NCIt + cde_id: C62198 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62198" + term_id: C62198 + term_version: 20.10d + +nonsmall_cell_carcinoma: + common: + description: >- + A malignant epithelial neoplasm characterized by the absence of neoplastic small + epithelial cells. A representative example is the lung non-small cell carcinoma. + termDef: + term: >- + Non-Small Cell Carcinoma + source: NCIt + cde_id: C65151 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65151" + term_id: C65151 + term_version: 20.05a + +nonwntnonshh_activated: + common: + description: >- + Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog + (SHH) pathway. TP53 mutations are absent. This molecular subtype includes medulloblastomas + numerically designated as "group 3" and "group 4". + termDef: + term: >- + Medulloblastoma, Non-WNT/Non-SHH + source: NCIt + cde_id: C129444 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129444" + term_id: C129444 + term_version: 20.05a + +normal: + common: + description: >- + Being approximately average or within certain limits; conforming with or constituting + a norm or standard or level or type or social norm. + termDef: + term: >- + Normal + source: NCIt + cde_id: C14165 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C14165" + term_id: C14165 + term_version: 20.10d + +north_korea: + common: + description: >- + A country in eastern Asia, occupying the northern half of the Korean Peninsula, + bordering the Korea Bay and the Sea of Japan, between China and South Korea. + termDef: + term: >- + North Korea + source: NCIt + cde_id: C16773 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16773" + term_id: C16773 + term_version: 19.12e + +north_macedonia: + common: + description: >- + A country in southeastern Europe, north of Greece, between Albania and Bulgaria. + termDef: + term: >- + North Macedonia + source: NCIt + cde_id: C17654 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17654" + term_id: C17654 + term_version: 19.12e + +northern_mariana_islands: + common: + description: >- + A country in the Pacific, comprising islands in the North Pacific Ocean, about + three-quarters of the way from Hawaii to the Philippines, north of Guam. + termDef: + term: >- + Northern Mariana Islands + source: NCIt + cde_id: C17882 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17882" + term_id: C17882 + term_version: 19.12e + +norway: + common: + description: >- + A country in northern Europe, bordering the North Sea and the North Atlantic + Ocean, west of Sweden. + termDef: + term: >- + Norway + source: NCIt + cde_id: C16920 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16920" + term_id: C16920 + term_version: 19.12e + +not_allowed_to_collect: + common: + description: >- + An indicator that specifies that a collection event was not permitted. + termDef: + term: >- + Not Allowed To Collect + source: NCIt + cde_id: C141478 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C141478" + term_id: C141478 + term_version: 19.12e + +not_applicable: + common: + description: >- + Determination of a value is not relevant in the current context. + termDef: + term: >- + Not Applicable + source: NCIt + cde_id: C48660 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48660" + term_id: C48660 + term_version: 20.10d + +not_cancer_related: + common: + description: >- + A death attributed to any cause other than the progression of a cancer-related + pathologic condition. + termDef: + term: >- + Non-Cancer Related Death + source: NCIt + cde_id: C156428 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156428" + term_id: C156428 + term_version: 19.12e + +not_determined: + common: + description: >- + A medulloblastoma which has not been further characterized. + termDef: + term: >- + Medulloblastoma, Not Otherwise Specified + source: NCIt + cde_id: C129447 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129447" + term_id: C129447 + term_version: 20.05a + +not_hispanic_or_latino: + common: + description: >- + A person not of Cuban, Mexican, Puerto Rican, South or Central American, or + other Spanish culture or origin, regardless of race. + termDef: + term: >- + Not Hispanic or Latino + source: NCIt + cde_id: C41222 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C41222" + term_id: C41222 + term_version: 19.12e + +not_reported: + common: + description: >- + Not provided or available. + termDef: + term: >- + Not Reported + source: NCIt + cde_id: C43234 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43234" + term_id: C43234 + term_version: 20.05a + +notch1: + common: + description: >- + This gene is involved in intercellular signal transduction that plays a key + role in development. + termDef: + term: >- + NOTCH1 Gene + source: NCIt + cde_id: C24636 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24636" + term_id: C24636 + term_version: 20.10d + +notch2: + common: + description: >- + This gene plays a role in cell-cell signaling. + termDef: + term: >- + NOTCH2 Gene + source: NCIt + cde_id: C97677 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97677" + term_id: C97677 + term_version: 20.10d + +npbno_palliative_benefit: + common: + description: >- + An indication that the treatment for a patient is not relieving symptoms or + providing comfort. + termDef: + term: >- + No Palliative Benefit + source: NCIt + cde_id: C165204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165204" + term_id: C165204 + term_version: 20.05a + +npm1: + common: + description: >- + This gene is involved in the regulation of ribosomal assembly. + termDef: + term: >- + NPM1 Gene + source: NCIt + cde_id: C21185 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21185" + term_id: C21185 + term_version: 20.10d + +nr4a3: + common: + description: >- + This gene is involved in the modulation of transcription. + termDef: + term: >- + NR4A3 Gene + source: NCIt + cde_id: C96007 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96007" + term_id: C96007 + term_version: 20.10d + +nras: + common: + description: >- + This gene plays a role in signal transduction and cell cycle regulation. + termDef: + term: >- + NRAS Gene + source: NCIt + cde_id: C25786 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25786" + term_id: C25786 + term_version: 20.10d + +nrg1: + common: + description: >- + This gene plays a role in cellular differentiation, growth and proliferation. + termDef: + term: >- + NRG1 Gene + source: NCIt + cde_id: C20174 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20174" + term_id: C20174 + term_version: 20.10d + +nrno_response: + common: + description: >- + No apparent change or worsening in lesion staging classification. + termDef: + term: >- + No Response + source: NCIt + cde_id: C123600 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123600" + term_id: C123600 + term_version: 20.05a + +nsd1: + common: + description: >- + This gene is involved in the mediation of histone methylation. + termDef: + term: >- + NSD1 Gene + source: NCIt + cde_id: C75876 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75876" + term_id: C75876 + term_version: 20.10d + +nsd2: + common: + description: >- + This gene plays a role in histone-lysine methylation. + termDef: + term: >- + NSD2 Gene + source: NCIt + cde_id: C21416 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21416" + term_id: C21416 + term_version: 20.10d + +nsd3: + common: + description: >- + This gene is involved in histone methylation. + termDef: + term: >- + NSD3 Gene + source: NCIt + cde_id: C96341 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96341" + term_id: C96341 + term_version: 20.10d + +nse: + common: + description: >- + Gamma-enolase (434 aa, ~47 kDa) is encoded by the human ENO2 gene. This protein + is involved in glycolysis, neurotrophy and neuroprotection. + termDef: + term: >- + Gamma-Enolase + source: NCIt + cde_id: C62216 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62216" + term_id: C62216 + term_version: 20.10d + +nt5c2: + common: + description: >- + This gene plays a role in purine metabolism. + termDef: + term: >- + NT5C2 Gene + source: NCIt + cde_id: C104587 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104587" + term_id: C104587 + term_version: 20.10d + +nthl1: + common: + description: >- + This gene plays a role in nucleotide-excision DNA repair. + termDef: + term: >- + NTHL1 Gene + source: NCIt + cde_id: C106190 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106190" + term_id: C106190 + term_version: 20.10d + +ntrk1: + common: + description: >- + This gene is involved in cellular differentiation and neurotrophic functions. + termDef: + term: >- + NTRK1 Gene + source: NCIt + cde_id: C18551 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18551" + term_id: C18551 + term_version: 20.10d + +ntrk3: + common: + description: >- + This gene plays a role in neuronal development and cellular differentiation. + Mutations in the gene are associated with medulloblastomas, secretory breast + carcinomas and other cancers. + termDef: + term: >- + NTRK3 Gene + source: NCIt + cde_id: C24647 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24647" + term_id: C24647 + term_version: 20.10d + +nuclear_staining: + common: + description: >- + A microscopy staining method that uses a dye or a contrast agent that specifically + binds to chromosomal material and/or nucleoproteins, which permits visualization + of a cellular nucleus. + termDef: + term: >- + Nuclear Staining Method + source: NCIt + cde_id: C165224 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165224" + term_id: C165224 + term_version: 20.10d + +nullizygous: + common: + description: >- + Having no copies, or nonfunctional copies, of a particular gene or genetic region. + termDef: + term: >- + Nullizygosity + source: NCIt + cde_id: C148063 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148063" + term_id: C148063 + term_version: 20.10d + +numa1: + common: + description: >- + This gene plays an essential role in normal mitosis. It is also involved in + cell organization/biogenesis. + termDef: + term: >- + NUMA1 Gene + source: NCIt + cde_id: C24648 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24648" + term_id: C24648 + term_version: 20.10d + +numidargistat: + common: + description: >- + An orally available inhibitor of arginase, a manganese-dependent enzyme that + hydrolyzes the amino acid arginine to form ornithine and urea, with potential + immunomodulating and antineoplastic activities. Upon administration, numidargistat + inhibits the breakdown of arginine by arginase, which is produced by myeloid + cells, and restores arginine levels. This allows arginine to stimulate the synthesis + of nitric oxide and the secretion of pro-inflammatory cytokines and chemokines, + which induces the proliferation and activation of T-cells. Therefore, this agent + may prevent the immunosuppressive effects of tumor-infiltrating myeloid cells + and promote lymphocyte-mediated immune responses against tumor cells. Arginase + is produced by neutrophils, macrophages and myeloid-derived suppressor cells + (MDSC) and plays a role in inflammation-associated immunosuppression. + termDef: + term: >- + Numidargistat + source: NCIt + cde_id: C142866 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142866" + term_id: C142866 + term_version: 20.10d + +nup214: + common: + description: >- + This gene plays a critical role in nuclear transport and docking regulation. + Alterations in the gene have been associated with several cancers and leukemias. + termDef: + term: >- + NUP214 Gene + source: NCIt + cde_id: C24649 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24649" + term_id: C24649 + term_version: 20.10d + +nup98: + common: + description: >- + This gene plays a role in transport and is frequently overexpressed in prostate + cancers. + termDef: + term: >- + NUP98 Gene + source: NCIt + cde_id: C20820 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20820" + term_id: C20820 + term_version: 20.10d + +nurulimab: + common: + description: >- + A monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic + T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint + inhibitory and antineoplastic activities. Upon administration, nurulimab targets + and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation + of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated + immune response against cancer cells. CTLA-4, an inhibitory receptor and member + of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation + of the immune system. + termDef: + term: >- + Nurulimab + source: NCIt + cde_id: C156734 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156734" + term_id: C156734 + term_version: 20.10d + +nut_carcinoma: + common: + description: >- + A rare, highly aggressive and lethal carcinoma that affects children and young + adults. It arises from midline epithelial structures, most commonly the head, + neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized + by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) + is present that results in the creation of a fusion gene involving the NUT gene, + most commonly BRD4-NUT fusion gene. + termDef: + term: >- + NUT Carcinoma + source: NCIt + cde_id: C45716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45716" + term_id: C45716 + term_version: 20.05a + +nut_midline_carcinoma: + common: + description: >- + A rare, highly aggressive and lethal carcinoma that affects children and young + adults. It arises from midline epithelial structures, most commonly the head, + neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized + by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) + is present that results in the creation of a fusion gene involving the NUT gene, + most commonly BRD4-NUT fusion gene. + termDef: + term: >- + NUT Carcinoma + source: NCIt + cde_id: C45716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45716" + term_id: C45716 + term_version: 20.05a + +nutm1: + common: + description: >- + This gene may be involved in testicular function. + termDef: + term: >- + NUTM1 Gene + source: NCIt + cde_id: C92705 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92705" + term_id: C92705 + term_version: 20.10d + +nutm2a: + common: + description: >- + This gene has an unknown function. + termDef: + term: >- + NUTM2A Gene + source: NCIt + cde_id: C101098 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101098" + term_id: C101098 + term_version: 20.10d + +nutm2b: + common: + description: >- + The function of this gene is unknown. + termDef: + term: >- + NUTM2B Gene + source: NCIt + cde_id: C101101 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101101" + term_id: C101101 + term_version: 20.10d + +nx: + common: + description: >- + A regional lymph node TNM finding indicating that the status of regional lymph + nodes cannot be assessed. + termDef: + term: >- + NX Stage Finding + source: NCIt + cde_id: C48718 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48718" + term_id: C48718 + term_version: 20.05a + +oat_cell_carcinoma: + common: + description: >- + A neuroendocrine carcinoma composed of small malignant cells which are often + said to resemble "oat cells" under the microscope. Small cell carcinoma most + often affects the lungs. Clinically, this is often a rapidly growing cancer + that spreads to distant sites early. + termDef: + term: >- + Small Cell Carcinoma + source: NCIt + cde_id: C3915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3915" + term_id: C3915 + term_version: 20.05a + +occasional_drinker: + common: + description: >- + An individual who drinks from time to time, but generally less than once per + week. + termDef: + term: >- + Occasional Drinker + source: NCIt + cde_id: C126382 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126382" + term_id: C126382 + term_version: 19.12e + +occipital: + common: + description: >- + A lymph node located in the back of the head adjacent to the trapezius muscle. + termDef: + term: >- + Occipital Lymph Node + source: NCIt + cde_id: C98188 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98188" + term_id: C98188 + term_version: 20.10d + +occipital_lobe: + common: + description: >- + One of the four regions of cortex in each cerebral hemisphere. It is located + posterior to the temporal lobe and inferior to the parietal lobe. + termDef: + term: >- + Occipital Lobe + source: NCIt + cde_id: C12355 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12355" + term_id: C12355 + term_version: 20.05a + +odontoameloblastoma: + common: + description: >- + A rare, locally aggressive neoplasm arising from tooth-forming tissues. It occurs + in the mandible and maxilla. It is characterized by the presence of odontogenic + epithelium and adjacent myxoid tissue, fibrous stroma, and mineralized dental + tissues. + termDef: + term: >- + Odontoameloblastoma + source: NCIt + cde_id: C54317 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54317" + term_id: C54317 + term_version: 20.05a + +odontogenic_carcinoma: + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial + skeleton or the gingiva. Symptoms include swelling, pain, bleeding, mobility + of affected teeth, and oral mucosa ulcerations. It may metastasize to lymph + nodes and distant anatomic sites early. + termDef: + term: >- + Malignant Odontogenic Neoplasm + source: NCIt + cde_id: C4812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4812" + term_id: C4812 + term_version: 20.05a + +odontogenic_carcinosarcoma: + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial + skeleton or the gingiva. Symptoms include swelling, pain, bleeding, mobility + of affected teeth, and oral mucosa ulcerations. It may metastasize to lymph + nodes and distant anatomic sites early. + termDef: + term: >- + Malignant Odontogenic Neoplasm + source: NCIt + cde_id: C4812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4812" + term_id: C4812 + term_version: 20.05a + +odontogenic_fibroma_nos: + common: + description: >- + A rare, benign, intraosseous neoplasm arising from tooth-forming tissues in + the mandible and maxilla. It is characterized by the presence of odontogenic + epithelium which is embedded in a fibrous stroma. Local enucleation of the tumor + is curative. + termDef: + term: >- + Odontogenic Fibroma + source: NCIt + cde_id: C4314 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4314" + term_id: C4314 + term_version: 20.05a + +odontogenic_fibrosarcoma: + common: + description: >- + A locally aggressive malignant neoplasm arising from odontogenic tissue. It + occurs in the mandible and less often in the maxilla. It is characterized by + the presence of a malignant connective tissue component and a benign epithelial + component. The frequency of distal metastases is low. + termDef: + term: >- + Ameloblastic Fibrosarcoma + source: NCIt + cde_id: C4317 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4317" + term_id: C4317 + term_version: 20.05a + +odontogenic_ghost_cell_tumor: + common: + description: >- + A locally aggressive neoplasm arising from tooth-forming tissues. It is more + often intraosseous and less frequently extraosseous and occurs in the jaw. It + is characterized by the presence of ameloblastoma-like epithelium, connective + tissue stroma, ghost cells, and dysplastic dentin. Wide local resection is recommended + for intraosseous neoplasms and enucleation for extraosseous neoplasms. + termDef: + term: >- + Dentinogenic Ghost Cell Tumor + source: NCIt + cde_id: C54323 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54323" + term_id: C54323 + term_version: 20.05a + +odontogenic_myxofibroma: + common: + description: >- + An intraosseous odontogenic neoplasm with good prognosis, arising from the mandible + and less frequently from the maxilla. It is characterized by the presence of + stellate cells, myxoid stroma formation, and prominent collagen. Small tumors + may be cured with enucleation. Complete excision may be required for larger + tumors. + termDef: + term: >- + Odontogenic Myxofibroma + source: NCIt + cde_id: C7452 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7452" + term_id: C7452 + term_version: 20.05a + +odontogenic_myxoma: + common: + description: >- + An intraosseous odontogenic neoplasm with good prognosis, arising from the mandible + and less frequently from the maxilla. It is characterized by the presence of + stellate cells and abundant myxoid stroma formation. Small tumors may be cured + with enucleation. Complete excision may be required for larger tumors. + termDef: + term: >- + Odontogenic Myxoma + source: NCIt + cde_id: C7501 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7501" + term_id: C7501 + term_version: 20.05a + +odontogenic_sarcoma: + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial + skeleton or the gingiva. Symptoms include swelling, pain, bleeding, mobility + of affected teeth, and oral mucosa ulcerations. It may metastasize to lymph + nodes and distant anatomic sites early. + termDef: + term: >- + Malignant Odontogenic Neoplasm + source: NCIt + cde_id: C4812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4812" + term_id: C4812 + term_version: 20.05a + +odontogenic_tumor_benign: + common: + description: >- + A benign, slow growing neoplasm arising from tooth-forming tissues. It occurs + in the maxillofacial skeleton or the gingiva. Representative examples include + adenomatoid odontogenic tumor, calcifying cystic odontogenic tumor, and squamous + odontogenic tumor. + termDef: + term: >- + Benign Odontogenic Neoplasm + source: NCIt + cde_id: C4306 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4306" + term_id: C4306 + term_version: 20.05a + +odontogenic_tumor_malignant: + common: + description: >- + A rare neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial + skeleton or the gingiva. Symptoms include swelling, pain, bleeding, mobility + of affected teeth, and oral mucosa ulcerations. It may metastasize to lymph + nodes and distant anatomic sites early. + termDef: + term: >- + Malignant Odontogenic Neoplasm + source: NCIt + cde_id: C4812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4812" + term_id: C4812 + term_version: 20.05a + +odontogenic_tumor_nos: + common: + description: >- + A benign or malignant neoplasm arising from tooth-forming tissues. It occurs + in the maxillofacial skeleton or the gingiva. Benign tumors are slow growing + and are not associated with specific clinical symptoms. Pain is absent or slight. + Malignant tumors are usually associated with rapid swelling and pain. + termDef: + term: >- + Odontogenic Neoplasm + source: NCIt + cde_id: C3286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3286" + term_id: C3286 + term_version: 20.05a + +odontoma_nos: + common: + description: >- + A benign, slow growing, and painless hamartomatous tumor occurring in tooth-bearing + areas of the jaws. According to the presence or absence of tooth-like structures, + it is classified as complex type or compound type. Odontoma of complex type + is characterized by the presence of enamel and dentin and the absence of tooth-like + structures. It is treated with local excision. If it is incompletely removed, + it may recur. Odontoma of compound type is characterized by the presence of + tooth-like structures. It is treated by local excision. Recurrences have not + been reported. + termDef: + term: >- + Odontoma + source: NCIt + cde_id: C3287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3287" + term_id: C3287 + term_version: 20.05a + +odronextamab: + common: + description: >- + A bispecific, human monoclonal antibody with potential antineoplastic activity. + Anti-CD20/CD3 monoclonal antibody REGN1979 contains two antigen-recognition + sites: one for human CD3, a T cell surface antigen, and one for human CD20, + a tumor-associated antigen that is exclusively expressed on B-cells during most + stages of B-cell development and is often overexpressed in B-cell malignancies. + Upon administration, odronextamab binds to both T-cells and CD20-expressing + tumor B-cells, which cross-links the T-cells to tumor cells, and may result + in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor + B-cells. + termDef: + term: >- + Odronextamab + source: NCIt + cde_id: C119615 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119615" + term_id: C119615 + term_version: 20.10d + +ofranergene_obadenovec: + common: + description: >- + A non-replicating adenovirus 5 (Ad-5, El-deleted) encoding a human Fas-chimera + (Fas-c) transgene under the control of a modified murine pre-proendothelin-1 + (PPE-1) promoter, with potential anti-angiogenic activity. Upon the administration + of ofranergene obadenovec, the modified murine PPE-1 promoter is specifically + activated in PPE-1-expressing angiogenic endothelial cells residing in the tumor + microvasculature. Subsequently, the Fas-c pro-apoptotic transgene, containing + the human tumor necrosis factor (TNF) receptor 1 (TNFR-1/p55) and the signaling + domain of Fas, is expressed in angiogenic endothelial cells. Fas-mediated apoptosis + is activated via binding of the TNFR-1 receptor with TNF-alpha, which is more + abundant in the tumor microenvironment (TME), enhancing specificity and limiting + systemic toxicities. + termDef: + term: >- + Ofranergene Obadenovec + source: NCIt + cde_id: C71539 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71539" + term_id: C71539 + term_version: 20.10d + +oil_burning_smoke_kerosene: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced when kerosene is rapidly oxidized via combustion. + termDef: + term: >- + Kerosene Smoke Exposure + source: NCIt + cde_id: C164093 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164093" + term_id: C164093 + term_version: 19.12e + +oil_burning_smoke_nos: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when oils are rapidly oxidized via combustion. + termDef: + term: >- + Burning Oil Smoke Exposure + source: NCIt + cde_id: C164063 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164063" + term_id: C164063 + term_version: 19.12e + +olfactory_nerve: + common: + description: >- + The first cranial nerve. It is the shortest cranial nerve and of paramount importance + in the sense of smell. Its neurons are in the olfactory mucosa in the nasal + cavity. + termDef: + term: >- + Olfactory Nerve + source: NCIt + cde_id: C12759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12759" + term_id: C12759 + term_version: 20.05a + +olfactory_neuroblastoma: + common: + description: >- + A rare neuroectodermal tumor originating from olfactory receptor cells in the + nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic + differentiation with occasional formation of rosettes. If the tumor is not resected + at an early stage, the prognosis is usually poor. + termDef: + term: >- + Olfactory Neuroblastoma + source: NCIt + cde_id: C3789 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3789" + term_id: C3789 + term_version: 20.05a + +olfactory_neurocytoma: + common: + description: >- + A rare benign neuroectodermal tumor originating from olfactory receptor cells + in the nasal cavity. Microscopically, it is characterized by the absence of + malignant characteristics and the absence of rosettes formation. + termDef: + term: >- + Olfactory Neurocytoma + source: NCIt + cde_id: C67156 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67156" + term_id: C67156 + term_version: 20.05a + +olfactory_neuroepithelioma: + common: + description: >- + A rare neuroectodermal tumor originating from olfactory receptor cells in the + nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic + differentiation with occasional formation of rosettes. If the tumor is not resected + at an early stage, the prognosis is usually poor. + termDef: + term: >- + Olfactory Neuroblastoma + source: NCIt + cde_id: C3789 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3789" + term_id: C3789 + term_version: 20.05a + +olfactory_neurogenic_tumor: + common: + description: >- + A rare, benign (olfactory neurocytoma) or malignant (olfactory neuroblastoma) + neuroectodermal tumor originating from olfactory receptor cells in the nasal + cavity. + termDef: + term: >- + Olfactory Neurogenic Tumor + source: NCIt + cde_id: C67155 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67155" + term_id: C67155 + term_version: 20.05a + +olig2: + common: + description: >- + This gene is involved in transcriptional regulation and oligodendrocyte and + motor neuron differentiation. This gene may play a role in the development of + brain tumors. + termDef: + term: >- + OLIG2 Gene + source: NCIt + cde_id: C68575 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68575" + term_id: C68575 + term_version: 20.10d + +oligoastrocytoma: + common: + description: >- + A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic + cell types morphologically resembling the tumor cells in oligodendroglioma and + diffuse astrocytoma. (WHO) + termDef: + term: >- + Oligoastrocytoma + source: NCIt + cde_id: C4050 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4050" + term_id: C4050 + term_version: 20.05a + +oligodendroblastoma: + common: + description: >- + An obsolete term referring to neoplasms arising from oligodendrocytes. + termDef: + term: >- + Oligodendroblastoma + source: NCIt + cde_id: C66802 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66802" + term_id: C66802 + term_version: 20.05a + +oligodendroglioma_anaplastic: + common: + description: >- + A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic + features (prominent nuclear pleomorphism, mitoses, and increased cellularity). + termDef: + term: >- + Anaplastic Oligodendroglioma + source: NCIt + cde_id: C4326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4326" + term_id: C4326 + term_version: 20.05a + +oligodendroglioma_idhmutant_and_1p19qcodeleted: + common: + description: >- + An oligodendroglioma carrying IDH gene family mutation and combined whole-arm + losses of 1p and 19q (1p/19q codeletion). + termDef: + term: >- + Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted + source: NCIt + cde_id: C129318 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129318" + term_id: C129318 + term_version: 20.05a + +oligodendroglioma_nos: + common: + description: >- + An oligodendroglioma in which there is insufficient information on the IDH genes + and 1p/19q codeletion status. + termDef: + term: >- + Oligodendroglioma, Not Otherwise Specified + source: NCIt + cde_id: C129319 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129319" + term_id: C129319 + term_version: 20.05a + +oligofucoidan: + common: + description: >- + A sulfated polysaccharide low-molecular-weight fucoidan, with potential antioxidant, + anti-inflammatory, antiproliferative, anti-angiogenic and pro-apoptotic activities. + Upon administration of oligo-fucoidan, this agent seems to exert numerous effects + through various mechanisms of action, some of which remain to be fully elucidated. + Oligo-fucoidan induces cell cycle arrest, activates caspases, induces apoptosis, + and inhibits tumor cell proliferation in susceptible tumor cells. It also increases + the expression of tumor suppressors, such as p53, while decreasing levels of + certain tumor promoters. Oligo-fucoidan also promotes the degradation of transforming + growth factor-beta (TGFb) receptor and the inhibition of epithelial-mesenchymal + transition (EMT). It prevents tumor progression, alters tumor microenvironment + (TME) and decreases the tumor-promoting M2 macrophages in the TME. Oligo-fucoidan + has anti-inflammatory effects that suppress the expression of nitric oxide synthase + (iNOS), cyclooxygenase (COX)-2 and monocyte chemoattractant protein-1 (MCP-1/CCL2), + and decrease the production of certain pro-inflammatory cytokines, such as interleukin-1beta + (IL-1b) and tumor necrosis factor (TNF)-alpha (TNFa). This agent may also suppress + angiogenic activity by inhibiting vascular endothelial growth factor (VEGF) + receptor expression and VEGF-induced endothelial cell proliferation. As an antioxidant, + this agent protects cells against oxidative stress by scavenging superoxide + radicals and induces the expression of the anti-oxidant nuclear factor erythroid-2-related + factor 2 and that of its target gene, superoxide dismutase; and prevents reactive + oxidative species (ROS) generation in cancer cells and ROS release into the + TME. Fucoidan also has immune-modulatory effects and enhances the proliferation + of natural killer (NKs) cells and cytotoxic T-cells (CTLs). + termDef: + term: >- + Oligo-fucoidan + source: NCIt + cde_id: C170752 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170752" + term_id: C170752 + term_version: 20.10d + +olinvacimab: + common: + description: >- + A fully human monoclonal antibody targeting the vascular endothelial growth + factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, + olinvacimab specifically binds to VEGFR2, thereby preventing the binding of + its ligand VEGF. This may result in the inhibition of tumor angiogenesis and + a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor + receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed + in many tumors and is correlated to tumor progression. + termDef: + term: >- + Olinvacimab + source: NCIt + cde_id: C102877 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102877" + term_id: C102877 + term_version: 20.10d + +olvimulogene_nanivacirepvec: + common: + description: >- + An attenuated oncolytic vaccinia virus encoding the light-emitting fusion protein + Renilla luciferase-Aequorea green fluorescent protein (RUC-GFP) with potential + bioluminescent and antineoplastic activities. Upon administration, light-emitting + oncolytic vaccinia virus GL-ONC1 specifically enters tumor cells due to the + permeable nature of the tumor vasculature. Once inside the cell, the virus replicates, + resulting in tumor cell lysis and the release of mature viral particles into + the tumor microenvironment. Released viral particles may then infect and destroy + neighboring tumor cells. In addition, the release of tumor-associated antigens + (TAAs) by lysed tumor cells into the bloodstream may activate the immune system + to mount a cytotoxic T lymphocyte (CTL) response against the tumor. The expression + of RUC-GFP by this agent allows for both detection and monitoring of virally + infected tumor cells in vivo and vitro with luciferase-mediated bioluminescence + imaging and fluorescence imaging techniques. + termDef: + term: >- + Olvimulogene Nanivacirepvec + source: NCIt + cde_id: C79833 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C79833" + term_id: C79833 + term_version: 20.10d + +oman: + common: + description: >- + A country in the Middle East, bordering the Arabian Sea, southeast of Saudi + Arabia. + termDef: + term: >- + Oman + source: NCIt + cde_id: C16933 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16933" + term_id: C16933 + term_version: 19.12e + +omd: + common: + description: >- + This gene is involved in cell adhesion. + termDef: + term: >- + OMD Gene + source: NCIt + cde_id: C97680 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97680" + term_id: C97680 + term_version: 20.10d + +omentum: + common: + description: >- + A fold of peritoneum originating at the stomach and supporting the viscera. + termDef: + term: >- + Omentum + source: NCIt + cde_id: C33209 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33209" + term_id: C33209 + term_version: 20.05a + +onatasertib: + common: + description: >- + An orally available inhibitor of the mammalian target of rapamycin (mTOR) with + potential antineoplastic activity. Onatasertib inhibits the activity of mTOR, + which may result in the induction of tumor cell apoptosis and a decrease in + tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated + in a variety of tumors, plays an important role downstream in the PI3K/AKT/mTOR + signaling pathway, which is frequently dysregulated in human cancers. + termDef: + term: >- + Onatasertib + source: NCIt + cde_id: C92575 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92575" + term_id: C92575 + term_version: 20.10d + +oncocytic_adenocarcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of large malignant epithelial + cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative + examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast + carcinoma, and salivary gland oncocytic carcinoma. + termDef: + term: >- + Oxyphilic Adenocarcinoma + source: NCIt + cde_id: C3679 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3679" + term_id: C3679 + term_version: 20.05a + +oncocytic_adenoma: + common: + description: >- + A benign neoplasm composed of large cells with abundant eosinophilic granular + cytoplasm. Representative examples include oncocytic adenomas of the thyroid + gland, parathyroid gland, and pituitary gland. + termDef: + term: >- + Oncocytic Adenoma + source: NCIt + cde_id: C3759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3759" + term_id: C3759 + term_version: 20.05a + +oncocytic_carcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of large malignant epithelial + cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative + examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast + carcinoma, and salivary gland oncocytic carcinoma. + termDef: + term: >- + Oxyphilic Adenocarcinoma + source: NCIt + cde_id: C3679 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3679" + term_id: C3679 + term_version: 20.05a + +oncocytic_schneiderian_papilloma: + common: + description: >- + A benign neoplasm with exophytic and endophytic growth arising from the lateral + nasal wall or the paranasal sinuses. It is characterized by the proliferation + of columnar cells with oncocytic features. Microcysts containing mucin and neutrophils + are present in the epithelium. Clinical manifestations include nasal obstruction + and epistaxis. Occasionally, it is associated with the development or presence + of a carcinoma, usually squamous cell carcinoma. + termDef: + term: >- + Sinonasal Oncocytic Schneiderian Papilloma + source: NCIt + cde_id: C54345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54345" + term_id: C54345 + term_version: 20.05a + +oncocytoma: + common: + description: >- + A usually benign neoplasm composed of large cells with abundant eosinophilic + granular cytoplasm. Representative examples include oncocytic neoplasms of + the thyroid gland, and kidney. (NCI05) + termDef: + term: >- + Oncocytic Neoplasm + source: NCIt + cde_id: C7072 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7072" + term_id: C7072 + term_version: 20.05a + +oncolytic_adenovirus_orca010: + common: + description: >- + A replication competent, oncolytic adenovirus serotype 5 (Ad5) that has been + modified with a delta24 (d24) deletion, an incorporation of an RGD-4C motif + in the Ad fiber protein, and an insertion of the T1 mutation in E3/19K gene, + with potential oncolytic activity. Upon administration, oncolytic adenovirus + ORCA-010 binds to specific Ad3 receptors that are highly expressed on certain + tumor cells. This results in the replication of oncolytic adenovirus Ad5/3-delta24 + in tumor cells and induces tumor cell lysis which may potentially result in + the activation of a systemic immune response against tumor-associated antigens + (TAAs). The Ad5/3-delta24 has a 24 base pair deletion in constant region 2 of + the E1A gene which allows for selective replication in cells that are defective + in the retinoblastoma gene (Rb) or cyclin-dependent kinase inhibitor-2A (CDKN2A + or p16INK4a). As most tumor cells are defective in the Rb/p16 pathway, this + virus selectively replicates in these cells. The RGD-4C motif is a 9-amino acid + peptide that binds to various and enhances viral-cell receptor binding by allowing + for a Coxsackie-adenovirus receptor (CAR)-independent infection of tumor cells, + which is the natural route of viral binding, as CAR expression is often deficient + on cancer cells. As integrins are often overexpressed on tumor cell surfaces, + integrin receptor binding enhances tumor cells binding and infection by the + Ad. The T1 mutation enhances the Ad5 release from tumor cells and promotes spreading + throughout the tumor, thereby enhancing anti-tumor activity. The T1 mutation, + a single Adenine insertion at position 445 of the nucleotide sequence of the + E3/19K gene of Adenovirus, creates a truncated E3/19K protein that is relocated + to the plasma membrane due to the disruption of its ER retention signal. This + increases plasma membrane permeability and enhances the release of Ad5. + termDef: + term: >- + Oncolytic Adenovirus ORCA-010 + source: NCIt + cde_id: C168607 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168607" + term_id: C168607 + term_version: 20.10d + +oncolytic_herpes_simplex_virus1_oncr177: + common: + description: >- + A recombinant, genetically modified, microRNA (miRNA)-attenuated oncolytic viral + strain of the herpes simplex type 1 (HSV-1) virus, with potential oncolytic, + immunostimulating and antineoplastic activities. In ONCR-177, a dual bidirectional + promoter enables the expression of five different transgenes: the natural killer + (NK) cell and T-cell activating cytokine interleuin-12 (IL-12), the chemokines + C-C motif chemokine 4 (CCL4) and the extracellular domain of the Fms-related + tyrosine kinase 3 ligand (FLT3LG), to allow for expansion and recruitment of + classical dendritic cells (DCs), and antagonists to the immune checkpoints programmed + cell death protein-1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 + (CTLA-4) to counter T cell exhaustion. Upon intra-tumoral administration, the + oncolytic HSV-1 ONCR-177 specifically targets, infects and selectively replicates + in tumor cells only while not infecting normal, healthy cells. This induces + tumor cell lysis. The released virus particles then infect and replicate in + neighboring tumor cells, thereby further killing tumor cells. The released tumor-associated + antigens (TAAs) from the tumor cells activate the immune system to exert an + anti-tumor immune response against the tumor cells, thereby further killing + the tumor cells. In addition, the expressed transgenes that are released upon + tumor cell lysis induce a systemic tumor-specific immune response and activate + NKs, DCs and cytotoxic T-lymphocytes (CTLs) while inhibiting regulatory T-cells + (Tregs). This further kills nearby non-infected tumor cells. In ONCR-177, the + neurovirulence gene ICP34.5 allows for potent oncolysis, even in the presence + of host cell antiviral responses. To ensure selective replication and oncolysis + in cancer cells while attenuating replication in healthy tissue, tissue specific + miRNA-binding cassettes (miR-T) are inserted into early genes essential for + viral replication. In addition, UL37 mutation suppresses latent infection. + termDef: + term: >- + Oncolytic Herpes Simplex Virus-1 ONCR-177 + source: NCIt + cde_id: C171540 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171540" + term_id: C171540 + term_version: 20.10d + +oncolytic_hsv1_expressing_il12_and_antipd1_antibody_t3011: + common: + description: >- + A genetically engineered oncolytic herpes simplex virus type 1 (oHSV-1) expressing + the human immunostimulating cytokine interleukin-12 (IL-12) and an antibody + directed against the negative immunoregulatory human cell receptor programmed + cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint + inhibitory and antineoplastic activities. Upon intratumoral administration, + oHSV-1 expressing IL-12 and anti-PD-1 antibody T3011 infects and replicates + in tumor cells causing viral-mediated tumor cell lysis. The released virus particles, + in turn, infect and replicate in neighboring tumor cells. Tumor antigens released + from the lysed tumor cells also activate the immune system to induce a tumor-specific + systemic immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby + non-infected tumor cells. In addition, oHSV-1 expressing IL-12 and anti-PD-1 + antibody T3011 promotes the secretion of IL-12 and anti-PD-1 antibody by the + tumor cells. IL-12 promotes the activation of natural killer cells, which induces + both the secretion of interferon-gamma and a cytotoxic T-lymphocyte (CTL) response + against the tumor cells. This results in both immune-mediated tumor cell death + and further inhibition of tumor cell proliferation. Anti-PD-1 antibody targets, + binds to and inhibits PD-1 and its downstream signaling pathways. This may restore + immune function through the activation of T-cells and T-cell-mediated immune + responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin + superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that + negatively regulates T-cell activation and effector function when activated + by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays + an important role in tumor evasion from host immunity. + termDef: + term: >- + Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011 + source: NCIt + cde_id: C175473 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175473" + term_id: C175473 + term_version: 20.10d + +oncolytic_measles_virus_encoding_helicobacter_pylori_neutrophilactivating_protein: + common: + description: >- + An attenuated oncolytic Edmonston (Ed) strain of measles virus (MV) encoding + the N-terminus of the human lambda immunoglobulin light chain containing the + Helicobacter pylori neutrophil-activating protein (NAP), with potential immunostimulating + and antineoplastic activities. Upon administration, the oncolytic measles virus + encoding H. pylori NAP selectively infects and replicates in tumor cells, leading + to syncytia formation and tumor cell lysis. The expressed NAP, a toll-like receptor-2 + (TLR2) agonist, may stimulate the secretion of proinflammatory cytokines such + as tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1 and IL-6, leading + to local inflammatory reaction in the tumor microenvironment (TME). H. pylori + NAP, a bacterial antigen and potent immunomodulator, may enhance the antitumor + effect of oncolytic MV. + termDef: + term: >- + Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating + Protein + source: NCIt + cde_id: C173889 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173889" + term_id: C173889 + term_version: 20.10d + +ontorpacept: + common: + description: >- + A soluble recombinant antibody-like fusion protein composed of the N-terminal + CD47 binding domain of human signal-regulatory protein alpha (SIRPa) linked + to the Fc domain of human immunoglobulin G1 (IgG1), with potential immune checkpoint + inhibitory and antineoplastic activities. Upon administration, ontorpacept selectively + targets and binds to CD47 expressed on tumor cells and blocks the interaction + of CD47 with endogenous SIRPa, a cell surface protein expressed on macrophages. + This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated + inhibition of macrophage activation and phagocytosis of cancer cells. This induces + pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which + is specifically expressed on the surface of tumor cells, to low-density lipoprotein + (LDL) receptor-related protein-1 (LRP-1), expressed on macrophages, and results + in macrophage activation and the specific phagocytosis of tumor cells. CD47, + also called integrin-associated protein (IAP), is a tumor-associated antigen + (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed + on the surface of a variety of cancer cells. Expression of CD47, and its interaction + with SIRPa, leads to the inhibition of macrophage activation and protects cancer + cells from phagocytosis, thereby allowing cancer cells to proliferate. + termDef: + term: >- + Ontorpacept + source: NCIt + cde_id: C125718 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125718" + term_id: C125718 + term_version: 20.10d + +onvatilimab: + common: + description: >- + A human monoclonal antibody against the protein V-domain immunoglobulin (Ig) + suppressor of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), + with potential negative checkpoint regulatory and antineoplastic activities. + Upon administration, onvatilimab targets and binds to VISTA. This inhibits VISTA + signaling, abrogates the VISTA-induced suppression of T-lymphocyte-mediated + immune responses, enhances cytotoxic T-cell responses against tumor cells and + inhibits tumor cell growth. VISTA, mainly expressed on hematopoietic cells, + plays a key role in immunosuppression. + termDef: + term: >- + Onvatilimab + source: NCIt + cde_id: C127124 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127124" + term_id: C127124 + term_version: 20.10d + +opolimogene_capmilisbac: + common: + description: >- + A proprietary, live-attenuated, double-deleted (LADD) strain of the Gram-positive + bacterium Listeria monocytogenes (Lm) encoding multiple, as of yet undisclosed, + tumor-associated antigens (TAAs), with potential immunostimulatory and antineoplastic + activities. Upon intravenous administration, opolimogene capmilisbac is taken + up by antigen-presenting cells (APCs), including dendritic cells (DCs). The + TAAs are subsequently expressed by the APCs and then processed and presented + to the immune system by both major histocompatibility complex (MHC) class I + and II molecules. This activates the immune system and leads to the recruitment + and activation of cytotoxic T-lymphocytes (CTLs) against the TAA-expressing + tumor cells, eventually resulting in tumor cell lysis. Two genes contributing + to the virulence of Lm have been removed to minimize the risk of infection. + termDef: + term: >- + Opolimogene Capmilisbac + source: NCIt + cde_id: C125631 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125631" + term_id: C125631 + term_version: 20.10d + +optic_nerve: + common: + description: >- + The second cranial nerve. + termDef: + term: >- + Optic Nerve + source: NCIt + cde_id: C12761 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12761" + term_id: C12761 + term_version: 20.05a + +opucolimab: + common: + description: >- + A recombinant human monoclonal antibody directed against the immunosuppressive + ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; + CD274), with potential immune checkpoint inhibitory and antineoplastic activities. + Upon administration, opucolimab specifically targets and binds to PD-L1, blocking + its binding to and activation of its receptor programmed cell death 1 (PD-1; + cluster of differentiation 279; CD279). This reverses T-cell inactivation caused + by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated + anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed + by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses + the immune system and results in immune evasion. PD-1, a transmembrane protein + belonging to the immunoglobulin superfamily (IgSF) expressed on activated T-cells, + is a negative regulator of the immune system that limits the expansion and survival + of CD8-positive T-cells. + termDef: + term: >- + Opucolimab + source: NCIt + cde_id: C165270 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165270" + term_id: C165270 + term_version: 20.10d + +orbit_nos: + common: + description: >- + The bony cavity of the skull which contains the eye, anterior portion of the + optic nerve, ocular muscles and ocular adnexa. Seven bones contribute to the + structure of the orbit: the frontal, maxillary, zygomatic, sphenoid, lacrimal, + ethmoid, and palatine bones. + termDef: + term: >- + Orbit + source: NCIt + cde_id: C12347 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12347" + term_id: C12347 + term_version: 20.05a + +orchioblastoma: + common: + description: >- + A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It + is the most common malignant germ cell tumor in the pediatric population. It + occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, + abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor + mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment + includes: surgical resection, radiation, and chemotherapy. This tumor is very + responsive to chemotherapy regimens that include cisplatinum. + termDef: + term: >- + Yolk Sac Tumor + source: NCIt + cde_id: C3011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3011" + term_id: C3011 + term_version: 20.05a + +orelabrutinib: + common: + description: >- + A small molecule inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia + tyrosine kinase) with potential antineoplastic activity. Upon administration, + orelabrutinib binds to and inhibits the activity of BTK. This prevents both + the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated + activation of downstream survival pathways, inhibiting the growth of malignant + B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family + of cytoplasmic tyrosine kinases, is overexpressed or mutated in B-cell malignancies; + it plays an important role in the development, activation, signaling, proliferation + and survival of B-lymphocytes. + termDef: + term: >- + Orelabrutinib + source: NCIt + cde_id: C156173 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156173" + term_id: C156173 + term_version: 20.10d + +oropharynx_nos: + common: + description: >- + The part of the pharynx between the soft palate and the upper portion of the + epiglottis. + termDef: + term: >- + Oropharynx + source: NCIt + cde_id: C12762 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12762" + term_id: C12762 + term_version: 20.05a + +orvacabtagene_autoleucel: + common: + description: >- + A preparation of autologous CD4- and CD8-positive T-lymphocytes that have been + ex vivo transduced with a genetically-engineered lentiviral vector (LV) expressing + a chimeric antigen receptor (CAR) containing a single chain variable fragment + (scFv) specific for the tumor-associated antigen (TAA) human B-cell maturation + antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) + fused to the co-stimulatory domain of 4-1BB (CD137) and the CD3-zeta (CD3z) + T-cell signaling domain, with potential immunostimulating and antineoplastic + activities. Upon administration, orvacabtagene autoleucel specifically recognize + and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific + antigen and a receptor for both a proliferation-inducing ligand (APRIL) and + B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor + superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found + on the surfaces of plasma cells and overexpressed on malignant plasma cells. + termDef: + term: >- + Orvacabtagene Autoleucel + source: NCIt + cde_id: C147523 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C147523" + term_id: C147523 + term_version: 20.10d + +ossifying_fibroma: + common: + description: >- + A well circumscribed lesion of the bone, most frequently arising from the posterior + mandible. It is characterized by the presence of fibrous tissue and a mineralized + component which may be woven bone, lamellar bone, or cementum-like material. + Complete removal is recommended, since it continues to enlarge if left untreated. + termDef: + term: >- + Ossifying Fibroma + source: NCIt + cde_id: C8422 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8422" + term_id: C8422 + term_version: 20.05a + +ossifying_fibromyxoid_tumor: + common: + description: >- + A rare soft tissue tumor of uncertain lineage characterized by the presence + of neoplastic spindle to round cells forming cords in a fibromyxoid stroma. The + lesions are associated with the formation of metaplastic bone. Most patients + present with painless subcutaneous masses. Recurrences have been reported in + a minority of patients. + termDef: + term: >- + Ossifying Fibromyxoid Tumor + source: NCIt + cde_id: C6582 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6582" + term_id: C6582 + term_version: 20.05a + +ossifying_fibromyxoid_tumor_malignant: + common: + description: >- + An ossifying fibromyxoid tumor characterized by the presence of high grade nuclear + features or increased cellularity and more than two mitotic figures per 50 HPFs. + termDef: + term: >- + Malignant Ossifying Fibromyxoid Tumor + source: NCIt + cde_id: C121774 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121774" + term_id: C121774 + term_version: 20.05a + +osteoblastic_sarcoma: + common: + description: >- + A conventional osteosarcoma characterized by the predominance of osteoid matrix. + termDef: + term: >- + Osteoblastic Osteosarcoma + source: NCIt + cde_id: C53953 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53953" + term_id: C53953 + term_version: 20.05a + +osteoblastoma_malignant: + common: + description: >- + An undifferentiated pleomorphic sarcoma characterized by the presence of osteoclast-like + giant cells and cellular pleomorphism. + termDef: + term: >- + Undifferentiated Pleomorphic Sarcoma with Osteoclast-Like Giant Cells + source: NCIt + cde_id: C8380 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8380" + term_id: C8380 + term_version: 20.05a + +osteoblastoma_nos: + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the spine. It is a + well-circumscribed lytic tumor that varies in size. The tumor is composed of + woven bone trabeculae and shares similar histologic characteristics with the + osteoid osteoma. Surgical curettage is the treatment of choice. The prognosis + is excellent. + termDef: + term: >- + Osteoblastoma + source: NCIt + cde_id: C3294 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3294" + term_id: C3294 + term_version: 20.05a + +osteocartilaginous_exostosis: + common: + description: >- + A common, benign cartiliginous neoplasm arising from the metaphysis of bone. + The tumor grows on the surface of the bone; it may be pedunculated or sessile. + It is characterized by the presence of chondrocytes, a cartilage cap, and a + fibrous perichondrium that extends to the periosteum of the bone. In some cases, + there is deletion of 8q24.1 chromosome locus. + termDef: + term: >- + Osteochondroma + source: NCIt + cde_id: C3295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3295" + term_id: C3295 + term_version: 20.05a + +osteochondroma: + common: + description: >- + A common, benign cartiliginous neoplasm arising from the metaphysis of bone. + The tumor grows on the surface of the bone; it may be pedunculated or sessile. + It is characterized by the presence of chondrocytes, a cartilage cap, and a + fibrous perichondrium that extends to the periosteum of the bone. In some cases, + there is deletion of 8q24.1 chromosome locus. + termDef: + term: >- + Osteochondroma + source: NCIt + cde_id: C3295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3295" + term_id: C3295 + term_version: 20.05a + +osteochondromatosis_nos: + common: + description: >- + An autosomal dominant neoplastic chondrogenic process affecting multiple sites. + It is caused by mutations in the EXT1 or EXT2 genes. Grossly and microscopically, + the lesions resemble an osteochondroma. + termDef: + term: >- + Multiple Osteochondromas + source: NCIt + cde_id: C53457 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53457" + term_id: C53457 + term_version: 20.05a + +osteochondrosarcoma: + common: + description: >- + An osteosarcoma characterised by the presence of atypical cartilage of variable + cellularity. It may or may not be associated with the presence of myxoid areas + or focal bone formation. + termDef: + term: >- + Chondroblastic Osteosarcoma + source: NCIt + cde_id: C4021 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4021" + term_id: C4021 + term_version: 20.05a + +osteofibrosarcoma: + common: + description: >- + A conventional osteosarcoma characterized by the presence of spindle shaped + cells. + termDef: + term: >- + Fibroblastic Osteosarcoma + source: NCIt + cde_id: C4020 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4020" + term_id: C4020 + term_version: 20.05a + +osteogenic_sarcoma_nos: + common: + description: >- + A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly + affecting adolescents and young adults. It usually involves bones and less frequently + extraosseous sites. It often involves the long bones (particularly distal femur, + proximal tibia, and proximal humerus). Pain with or without a palpable mass + is the most frequent clinical symptom. It may spread to other anatomic sites, + particularly the lungs. + termDef: + term: >- + Osteosarcoma + source: NCIt + cde_id: C9145 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9145" + term_id: C9145 + term_version: 20.05a + +osteoid_osteoma_nos: + common: + description: >- + A small, benign, bone-forming neoplasm that can arise from any bone but more + frequently affects the long bones. The central portion of the neoplasm (nidus) + contains differentiated osteoblasts which produce osteoid and sometimes bone. + The lesion is usually surrounded by hypervascular sclerotic bone and has limited + growth potential. Clinical signs and symptoms include pain and localized tenderness, + at the site of the lesion. The pain may be intense but in the majority of cases + it is completely alleviated by non-steroidal anti-inflammatory drugs. Prognosis + is excellent and recurrences are rare. + termDef: + term: >- + Osteoid Osteoma + source: NCIt + cde_id: C3297 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3297" + term_id: C3297 + term_version: 20.05a + +osteoma_nos: + common: + description: >- + A benign, well-circumscribed, bone-forming neoplasm predominantly composed of + lamellar bone. It usually arises from the calvarial, facial, or jaw bones. It + is usually asymptomatic but it may cause local swelling or obstruction of the + paranasal sinuses. Asymptomatic cases have an indolent clinical course. + termDef: + term: >- + Osteoma + source: NCIt + cde_id: C3296 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3296" + term_id: C3296 + term_version: 20.05a + +osteosarcoma: + common: + description: >- + A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly + affecting adolescents and young adults. It usually involves bones and less frequently + extraosseous sites. It often involves the long bones (particularly distal femur, + proximal tibia, and proximal humerus). Pain with or without a palpable mass + is the most frequent clinical symptom. It may spread to other anatomic sites, + particularly the lungs. + termDef: + term: >- + Osteosarcoma + source: NCIt + cde_id: C9145 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9145" + term_id: C9145 + term_version: 19.12e + +osteosarcoma_nos: + common: + description: >- + A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly + affecting adolescents and young adults. It usually involves bones and less frequently + extraosseous sites. It often involves the long bones (particularly distal femur, + proximal tibia, and proximal humerus). Pain with or without a palpable mass + is the most frequent clinical symptom. It may spread to other anatomic sites, + particularly the lungs. + termDef: + term: >- + Osteosarcoma + source: NCIt + cde_id: C9145 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9145" + term_id: C9145 + term_version: 20.05a + +other: + common: + description: >- + Different than the one(s) previously specified or mentioned. + termDef: + term: >- + Other + source: NCIt + cde_id: C17649 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17649" + term_id: C17649 + term_version: 19.12e + +other_illdefined_sites: + common: + description: >- + An anatomic site that is not specified or defined well enough to associate with + a specific site. + termDef: + term: >- + Ill-Defined Anatomic Site + source: NCIt + cde_id: C147919 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C147919" + term_id: C147919 + term_version: 20.05a + +other_specified_parts_of_female_genital_organs: + common: + description: >- + Female genital organs that are referenced in topographic category C57 of ICD-O-3. + termDef: + term: >- + Other and Unspecified Female Genital Organs ICD-O-3 + source: NCIt + cde_id: C148339 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148339" + term_id: C148339 + term_version: 20.05a + +other_specified_parts_of_male_genital_organs: + common: + description: >- + Male genital organs that are referenced in topographic category C63 of ICD-O-3. + termDef: + term: >- + Other and Unspecified Male Genital Organs ICD-O-3 + source: NCIt + cde_id: C148341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148341" + term_id: C148341 + term_version: 20.05a + +other_specified_parts_of_pancreas: + common: + description: >- + Any component associated with the pancreas that is different from the one(s) + previously specified or mentioned. + termDef: + term: >- + Other Specified Parts of Pancreas + source: NCIt + cde_id: C12273 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12273" + term_id: C12273 + term_version: 20.05a + +ovarian_cancer: + common: + description: >- + A primary or metastatic malignant neoplasm involving the ovary. Most primary + malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid + adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms + to the ovary include carcinomas, lymphomas, and melanomas. + termDef: + term: >- + Malignant Ovarian Neoplasm + source: NCIt + cde_id: C7431 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7431" + term_id: C7431 + term_version: 19.12e + +ovarian_capsule_fragmented: + common: + description: >- + A microscopy finding indicating that a portion of the ovarian capsule in a biopsy + was fragmented. + termDef: + term: >- + Ovarian Capsule Fragmented + source: NCIt + cde_id: C164045 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164045" + term_id: C164045 + term_version: 20.05a + +ovarian_capsule_intact: + common: + description: >- + A microscopy finding indicating that the ovarian capsule in a biopsy is intact. + termDef: + term: >- + Ovarian Capsule Intact + source: NCIt + cde_id: C164042 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164042" + term_id: C164042 + term_version: 20.05a + +ovarian_capsule_ruptured: + common: + description: >- + A microscopy finding indicating that a portion of the ovarian capsule in a biopsy + has ruptured. + termDef: + term: >- + Ovarian Capsule Ruptured + source: NCIt + cde_id: C164044 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164044" + term_id: C164044 + term_version: 20.05a + +ovarian_stromal_tumor: + common: + description: >- + A benign or malignant neoplasm that arises from the ovary and is composed of + granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative + examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor. + termDef: + term: >- + Ovarian Sex Cord-Stromal Tumor + source: NCIt + cde_id: C4862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4862" + term_id: C4862 + term_version: 20.05a + +ovary: + common: + description: >- + One of the paired female reproductive glands containing the ova or germ cells; + the ovary's stroma is a vascular connective tissue containing numbers of ovarian + follicles enclosing the ova. + termDef: + term: >- + Ovary + source: NCIt + cde_id: C12404 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12404" + term_id: C12404 + term_version: 20.05a + +overexpressed: + common: + description: >- + Synthesis of excess polypeptide within the cell. Overexpression is often due + to the amplification or deregulation of the gene which encodes the gene product. + termDef: + term: >- + Protein Overexpression + source: NCIt + cde_id: C18211 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18211" + term_id: C18211 + term_version: 20.10d + +oxaliplatin_eluting_beads: + common: + description: >- + A formulation of drug-eluting beads (DEB) consisting of polymeric microbeads + impregnated with the organoplatinum complex and alkylating agent oxaliplatin, + with potential antineoplastic activity. The beads consist of polyvinyl alcohol + (PVA) microspheres modified with sulfonic acid groups and loaded with oxaliplatin. + During transarterial chemoembolization (TACE) in the hepatic artery, the oxaliplatin + eluting beads occlude tumor blood vessels that feed the tumor and induce ischemic + necrosis of tumor tissue due to mechanical blockage of the tumor vasculature. + The beads release cytotoxic oxaliplatin locally, which may result in oxaliplatin-mediated + inhibition of tumor cell proliferation through formation of both inter- and + intra-strand platinum-DNA crosslinks, and the inhibition of DNA replication. + termDef: + term: >- + Oxaliplatin Eluting Beads + source: NCIt + cde_id: C172098 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172098" + term_id: C172098 + term_version: 20.10d + +oxyphilic_adenocarcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of large malignant epithelial + cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative + examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast + carcinoma, and salivary gland oncocytic carcinoma. + termDef: + term: >- + Oxyphilic Adenocarcinoma + source: NCIt + cde_id: C3679 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3679" + term_id: C3679 + term_version: 20.05a + +oxyphilic_adenoma: + common: + description: >- + A benign neoplasm composed of large cells with abundant eosinophilic granular + cytoplasm. Representative examples include oncocytic adenomas of the thyroid + gland, parathyroid gland, and pituitary gland. + termDef: + term: >- + Oncocytic Adenoma + source: NCIt + cde_id: C3759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3759" + term_id: C3759 + term_version: 20.05a + +p2ry8: + common: + description: >- + This gene plays a role in signaling. + termDef: + term: >- + P2RY8 Gene + source: NCIt + cde_id: C97683 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97683" + term_id: C97683 + term_version: 20.10d + +p97_inhibitor_cb5339: + common: + description: >- + An orally bioavailable, selective, second-generation inhibitor of valosin-containing + protein (VCP)/p97, with potential antineoplastic activity. Upon oral administration, + p97 inhibitor CB-5339 binds to and inhibits the activity of p97. This prevents + ubiquitin-dependent protein degradation and causes cellular accumulation of + poly-ubiquitinated proteins. The inhibition of endoplasmic reticulum (ER)-associated + protein degradation activates the ER-dependent stress response pathway, and + leads to both an induction of apoptosis and the inhibition of cell proliferation + in susceptible tumor cells. VCP/p97, a type II AAA+ ATPase, plays a key role + in cellular protein homeostasis processes including ER-associated degradation + (ERAD), chromatin associated degradation (CAD) and the DNA damage response (DDR). Its + overexpression in many tumor cell types is associated with increased tumor cell + proliferation and survival. + termDef: + term: >- + p97 Inhibitor CB-5339 + source: NCIt + cde_id: C167257 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167257" + term_id: C167257 + term_version: 20.10d + +p97_inhibitor_cb5339_tosylate: + common: + description: >- + The tosylate salt of CB-5339, an orally bioavailable, selective, second-generation + inhibitor of valosin-containing protein (VCP)/p97, with potential antineoplastic + activity. Upon oral administration, p97 inhibitor CB-5339 binds to and inhibits + the activity of p97. This prevents ubiquitin-dependent protein degradation + and causes cellular accumulation of poly-ubiquitinated proteins. The inhibition + of endoplasmic reticulum (ER)-associated protein degradation activates the ER-dependent + stress response pathway, and leads to both an induction of apoptosis and the + inhibition of cell proliferation in susceptible tumor cells. VCP/p97, a type + II AAA+ ATPase, plays a key role in cellular protein homeostasis processes including + endoplasmic reticulum associated degradation (ERAD), chromatin associated degradation + (CAD) and the DNA damage response (DDR). Its overexpression in many tumor cell + types is associated with increased tumor cell proliferation and survival. + termDef: + term: >- + p97 Inhibitor CB-5339 Tosylate + source: NCIt + cde_id: C167262 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167262" + term_id: C167262 + term_version: 20.10d + +pabpc1: + common: + description: >- + This gene is involved in binding to poly(A)RNA. + termDef: + term: >- + PABPC1 Gene + source: NCIt + cde_id: C143072 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143072" + term_id: C143072 + term_version: 20.10d + +pacinian_tumor: + common: + description: >- + A neurofibroma characterized by the presence of structures which resemble Vater-Pacini + corpuscles. + termDef: + term: >- + Pacinian Neurofibroma + source: NCIt + cde_id: C4328 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4328" + term_id: C4328 + term_version: 20.05a + +pacmilimab: + common: + description: >- + A recombinant antibody prodrug composed of a monoclonal antibody directed against + the tumor-associated antigen (TAA) programmed cell death 1 ligand 1 (PD-L1; + B7-H1; CD274) that is linked to a proprietary masking peptide through a protease-cleavable + linker on the amino terminus of the light chain domain of the antibody, with + potential immune checkpoint inhibitory and antineoplastic activities. Upon administration + of pacmilimab, the linkage system is stable in the circulation and, upon extravasation + into the tumor microenvironment, the peptide mask is cleaved by tumor-associated + proteases. These proteases are present in high concentrations and aberrantly + activated in the tumor microenvironment, while expressed as inactive forms, + at much lower concentrations, in normal, healthy tissue. Protease cleavage of + the linker enables binding of the unmasked, fully active monoclonal antibody + moiety of CX-072 to PD-L1, which is over expressed on certain cancer cells. + This blocks the binding to and activation of its receptor programmed cell death + 1 (PD-1) on T-lymphocytes, thereby enhancing the T-cell-mediated anti-tumor + immune response and reversing PD-L1/PD-1-mediated T-cell suppression. PD-L1 + binding to PD-1 on T-cells suppresses the immune system and results in immune + evasion. Compared to the unmodified PD-L1 antibody, peptide masking of CX-072 + minimizes binding to PD-L1 in normal tissues, thereby decreasing autoimmune-based + side effects while retaining anti-tumor activity. + termDef: + term: >- + Pacmilimab + source: NCIt + cde_id: C132192 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132192" + term_id: C132192 + term_version: 20.10d + +pafah1b2: + common: + description: >- + This gene is involved in lipid metabolism. + termDef: + term: >- + PAFAH1B2 Gene + source: NCIt + cde_id: C97894 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97894" + term_id: C97894 + term_version: 20.10d + +paget_disease_and_intraductal_carcinoma_of_breast: + common: + description: >- + Paget disease of the breast associated with the presence of a usually high grade + ductal carcinoma in situ in the lactiferous glands. + termDef: + term: >- + Paget Disease and Intraductal Carcinoma of the Breast + source: NCIt + cde_id: C4019 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4019" + term_id: C4019 + term_version: 20.05a + +paget_disease_extramammary: + common: + description: >- + A malignant neoplasm in which there is infiltration of the skin by neoplastic + large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli + (Paget cells). It may affect the anus, penis, scrotum, and vulva. + termDef: + term: >- + Extramammary Paget Disease + source: NCIt + cde_id: C3302 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3302" + term_id: C3302 + term_version: 20.05a + +paget_disease_mammary: + common: + description: >- + A malignant neoplasm in which there is infiltration of the skin overlying the + breast by neoplastic large cells with abundant pale cytoplasm and large nuclei + with prominent nucleoli (Paget cells). It is almost always associated with an + intraductal or invasive ductal carcinoma of the breast. The clinical features + include focal skin reddening, and eczema. Retraction of the nipple may sometimes + occur. + termDef: + term: >- + Paget Disease of the Breast + source: NCIt + cde_id: C47857 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47857" + term_id: C47857 + term_version: 20.05a + +paget_disease_of_breast: + common: + description: >- + A malignant neoplasm in which there is infiltration of the skin overlying the + breast by neoplastic large cells with abundant pale cytoplasm and large nuclei + with prominent nucleoli (Paget cells). It is almost always associated with an + intraductal or invasive ductal carcinoma of the breast. The clinical features + include focal skin reddening, and eczema. Retraction of the nipple may sometimes + occur. + termDef: + term: >- + Paget Disease of the Breast + source: NCIt + cde_id: C47857 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47857" + term_id: C47857 + term_version: 20.05a + +pagetoid_reticulosis: + common: + description: >- + A variant of mycosis fungoides, characterized by an exclusively intraepidermal + atypical (cerebriform) lymphocytic infiltrate. Patients present with a localized + psoriasiform or hyperkeratotic patch or plaque, usually in the extremities. Extracutaneous + dissemination of the disease has never been reported. + termDef: + term: >- + Pagetoid Reticulosis + source: NCIt + cde_id: C35794 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35794" + term_id: C35794 + term_version: 20.05a + +pakistan: + common: + description: >- + A country in southern Asia, bordering the Arabian Sea, between India on the + east and Iran and Afghanistan on the west and China in the north. + termDef: + term: >- + Pakistan + source: NCIt + cde_id: C16949 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16949" + term_id: C16949 + term_version: 19.12e + +palate_nos: + common: + description: >- + The roof of the oral cavity. It separates the oral cavity from the nasal cavity. + termDef: + term: >- + Palate + source: NCIt + cde_id: C12229 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12229" + term_id: C12229 + term_version: 20.05a + +palau: + common: + description: >- + A country in the Pacific, comprising a group of islands in the North Pacific + Ocean, southeast of the Philippines and northwest of Papua New Guinea. + termDef: + term: >- + Palau + source: NCIt + cde_id: C17733 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17733" + term_id: C17733 + term_version: 19.12e + +palb2: + common: + description: >- + This gene may play a role in the repair of DNA damage that is resolved by recombination. + termDef: + term: >- + PALB2 Gene + source: NCIt + cde_id: C84945 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84945" + term_id: C84945 + term_version: 20.10d + +pamrevlumab: + common: + description: >- + A human monoclonal antibody targeting connective tissue growth factor (CTGF) + with potential anti-fibrotic and antineoplastic activities. Pamrevlumab binds + to CTGF thereby preventing the binding of the ligand to the receptor and subsequent + receptor activation. As CTGF enhances the production of collagen and fibronectin, + FG-319 may prevent and reverse fibrosis. In addition, FG-3019 may prevent tumor + cell proliferation in CTGF-expressing tumor cells. CTGF, a member of the CCN + family (CTGF, CYR61/CEF and NOV), is expressed in a variety of tumor cell types + and is involved in processes such as cell proliferation, cell migration, cell + adhesion, differentiation and angiogenesis. + termDef: + term: >- + Pamrevlumab + source: NCIt + cde_id: C92577 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92577" + term_id: C92577 + term_version: 20.10d + +panama: + common: + description: >- + A country in Central America, bordering both the Caribbean Sea and the North + Pacific Ocean, between Colombia and Costa Rica. + termDef: + term: >- + Panama + source: NCIt + cde_id: C16951 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16951" + term_id: C16951 + term_version: 19.12e + +pancreas: + common: + description: >- + An organ behind the lower part of the stomach that is the shape of a fish and + about the size of a hand. It is a compound gland composed of both exocrine and + endocrine tissues. The endocrine pancreas makes insulin so that the body can + use glucose (sugar) for energy. The exocrine pancreas makes enzymes that help + the body digest food. Spread all over the pancreas are areas called the Islets + of Langerhans. The cells in these areas each have a special purpose. The alpha + cells make glucagon, which raises the level of glucose in the blood; the beta + cells make insulin; the delta cells make somatostatin. There are also PP cells + and D1 cells, about which little is known. + termDef: + term: >- + Pancreas + source: NCIt + cde_id: C12393 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12393" + term_id: C12393 + term_version: 20.05a + +pancreas_cancer: + common: + description: >- + A carcinoma arising from the exocrine pancreas. The overwhelming majority of + pancreatic carcinomas are adenocarcinomas. + termDef: + term: >- + Pancreatic Carcinoma + source: NCIt + cde_id: C3850 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3850" + term_id: C3850 + term_version: 19.12e + +pancreas_nos: + common: + description: >- + An organ behind the lower part of the stomach that is the shape of a fish and + about the size of a hand. It is a compound gland composed of both exocrine and + endocrine tissues. The endocrine pancreas makes insulin so that the body can + use glucose (sugar) for energy. The exocrine pancreas makes enzymes that help + the body digest food. Spread all over the pancreas are areas called the Islets + of Langerhans. The cells in these areas each have a special purpose. The alpha + cells make glucagon, which raises the level of glucose in the blood; the beta + cells make insulin; the delta cells make somatostatin. There are also PP cells + and D1 cells, about which little is known. + termDef: + term: >- + Pancreas + source: NCIt + cde_id: C12393 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12393" + term_id: C12393 + term_version: 20.05a + +pancreatic_duct: + common: + description: >- + A duct joining the pancreas to the common bile duct to supply pancreatic juices. + termDef: + term: >- + Pancreatic Duct + source: NCIt + cde_id: C12272 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12272" + term_id: C12272 + term_version: 20.05a + +pancreatic_endocrine_tumor_nos: + common: + description: >- + A neoplasm with neuroendocrine differentiation that arises from the pancreas. It + includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine + carcinomas (high grade). + termDef: + term: >- + Pancreatic Neuroendocrine Neoplasm + source: NCIt + cde_id: C27031 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27031" + term_id: C27031 + term_version: 20.05a + +pancreatoblastoma: + common: + description: >- + A rare malignant epithelial neoplasm arising from the pancreas. The vast majority + of cases occur during childhood. It is characterized by acinar differentiation, + the formation of squamoid corpuscles, and the formation of stromal bands. Patients + may present with an abdominal mass. Symptoms include pain, weight loss, and + diarrhea. It may metastasize to lymph nodes, liver, and distant anatomic sites. + Children who do not have metastatic disease at the time of diagnosis usually + have a favorable clinical outcome when treated with a combination of surgery + and chemotherapy. However, children with metastatic disease at presentation + or adult patients usually have a poor prognosis. + termDef: + term: >- + Pancreatoblastoma + source: NCIt + cde_id: C4265 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4265" + term_id: C4265 + term_version: 20.05a + +pankras_inhibitor_bi_1701963: + common: + description: >- + An orally available protein-protein interaction (PPI) inhibitor that targets + the guanine nucleotide exchange factor Son of sevenless homolog 1 (SOS1), with + potential antineoplastic activity. Upon oral administration, pan-KRAS inhibitor + BI 1701963 selectively targets and binds to SOS1, thereby preventing the interaction + of SOS1 with Kirsten rat sarcoma viral oncogene homolog (KRAS) in the guanosine + diphosphate (GDP)-bound 'off' state, which is the inactivated state of KRAS. + This abrogates the exchange of RAS-bound GDP for guanosine triphosphate (GTP) + and prevents the formation of GTP-loaded KRAS, which is the activated 'on' state + of KRAS. This prevents activation of downstream RAF/mitogen-activated protein + kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway + by GTP-loaded KRAS. This inhibits mutant KRAS-dependent signaling and may inhibit + growth and survival of KRAS-expressing tumor cells. KRAS is a member of the + RAS family of oncogenes that is mutated in many cancer cell types. Mutations + of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, + survival, invasion, and metastasis. SOS1 regulates the KRAS GDP-GTP cycle and + promotes nucleotide exchange and formation of 'active' KRAS-GTP. + termDef: + term: >- + Pan-KRAS Inhibitor BI 1701963 + source: NCIt + cde_id: C166138 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166138" + term_id: C166138 + term_version: 20.10d + +panmutationselective_egfr_inhibitor_cln081: + common: + description: >- + An orally available selective inhibitor of a broad spectrum of epidermal growth + factor receptor (EGFR) mutations, including EGFR exon 20 insertion mutations + (EGFR Ex20ins; Ex20ins mutations), with potential antineoplastic activity. CLN-081 + is also active against other EGFR mutations including exon 19 deletions (exon19del), + L858R, and T790M, as well as the less common G719X, L861Q and S768I mutations. + Upon administration, the pan-mutation-selective EGFR inhibitor CLN-081 specifically + and covalently binds to and inhibits a variety of EGFR mutations, with particularly + high selectivity against EGFR Ex20ins, which prevents EGFR mutant-mediated signaling + and leads to cell death in EGFR mutant-expressing tumor cells. Compared to some + other EGFR inhibitors, CLN-081 may have therapeutic benefits in tumors with + EGFR Ex20ins, as most EGFR mutant-selective inhibitors are not active against + EGFR Ex20ins. This agent shows minimal activity against wild-type EGFR (wt EGFR), + and does not cause dose-limiting toxicities that occur during the use of non-selective + EGFR inhibitors, which also inhibit wt EGFR. EGFR, a receptor tyrosine kinase + mutated in many tumor cell types, plays a key role in tumor cell proliferation + and tumor vascularization. + termDef: + term: >- + Pan-mutation-selective EGFR Inhibitor CLN-081 + source: NCIt + cde_id: C165567 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165567" + term_id: C165567 + term_version: 20.10d + +pantrk_inhibitor_nov1601: + common: + description: >- + An orally bioavailable, selective pan-tropomyosin-related-kinase (tyrosine receptor + kinase; TRK) inhibitor, with potential antineoplastic activity. Upon oral administration, + pan-TRK inhibitor NOV1601 specifically targets and binds to TRK, TRK mutations + and fusion proteins containing sequences from neurotrophic tyrosine receptor + kinase (NTRK) types 1 (NTRK1; TrkA), 2 (NTRK2; TrkB), and 3 (NTRK3; TrkC). This + inhibits neurotrophin-TRK interaction and TRK activation, thereby preventing + the activation of downstream signaling pathways and resulting in both the induction + of cellular apoptosis and the inhibition of cell growth in tumors that overexpress + TRK and/or express NTRK fusion proteins. TRK, a family of receptor tyrosine + kinases (RTKs) activated by neurotrophins, is encoded by NTRK family genes. + The expression of either mutated forms of, or fusion proteins involving, NTRK + family members results in uncontrolled TRK signaling, which plays an important + role in tumor cell growth, survival, invasion and treatment resistance. + termDef: + term: >- + Pan-TRK Inhibitor NOV1601 + source: NCIt + cde_id: C172394 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172394" + term_id: C172394 + term_version: 20.10d + +panulisib: + common: + description: >- + An orally bioavailable inhibitor of phosphoinositide 3-kinase (PI3K), mammalian + target of rapamycin (mTOR), activin receptor-like kinase 1 (ALK-1) and DNA-dependent + protein kinase (DNA-PK), with potential anti-angiogenic and antineoplastic activities. + Upon oral administration, panulisib inhibits the activity of all four kinases. + This prevents PI3K/mTOR and ALK-1-mediated signaling pathways and may lead to + the inhibition of cancer cell growth in PI3K/mTOR-overexpressing tumor cells + and angiogenesis in ALK-1-overexpressing endothelial cells. Also, by inhibiting + DNA-PK, this agent inhibits the ability of tumor cells to repair damaged DNA. + The PI3K/mTOR pathway is upregulated in a variety of tumors and plays an important + role in regulating cancer cell proliferation, growth, and survival. ALK-1, a + member of the transforming growth factor beta (TGF-b) type I receptor family, + is overexpressed on endothelial cells in a variety of tumor types and increases + endothelial cell proliferation and migration. DNA-PK is activated upon DNA damage + and plays a key role in repairing double-stranded DNA breaks. + termDef: + term: >- + Panulisib + source: NCIt + cde_id: C104292 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104292" + term_id: C104292 + term_version: 20.10d + +pap_smear: + common: + description: >- + A biospecimen collection and staining procedure in which secretions and superficial + cells of the cervix are collected and stained with the Papanicolaou stain followed + by microscopic examination to identify the presence of abnormal cells. + termDef: + term: >- + Pap Smear + source: NCIt + cde_id: C17348 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17348" + term_id: C17348 + term_version: 20.05a + +papalliative_therapy: + common: + description: >- + The patient- and family-centered active holistic care of patients with advanced, + progressive disease. Essential components of palliative care are: pain and symptom + control, communication regarding treatment and alternatives, prognosis, and + available services, rehabilitation services, care that addresses treatment and + palliative concerns, intellectual, emotional, social, and spiritual needs, terminal + care, support in bereavement. The goal of palliative care is an achievement + of the best quality of life for patients and their families. + termDef: + term: >- + Palliative Therapy + source: NCIt + cde_id: C15292 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15292" + term_id: C15292 + term_version: 20.05a + +papillary_adenocarcinoma_nos: + common: + description: >- + A morphologic variant of adenocarcinoma. It is characterized by the presence + of a papillary growth pattern. Representative examples include thyroid gland + papillary carcinoma, invasive papillary breast carcinoma, and ovarian serous + surface papillary adenocarcinoma. + termDef: + term: >- + Papillary Adenocarcinoma + source: NCIt + cde_id: C2853 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2853" + term_id: C2853 + term_version: 20.05a + +papillary_adenofibroma: + common: + description: >- + A biphasic polypoid neoplasm characterized by the presence of papillary projections + that are lined by epithelial cells and fibrotic stroma. + termDef: + term: >- + Papillary Adenofibroma + source: NCIt + cde_id: C8986 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8986" + term_id: C8986 + term_version: 20.05a + +papillary_adenoma_nos: + common: + description: >- + Glandular Papilloma + termDef: + term: >- + Glandular Papilloma + source: NCIt + cde_id: C6880 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6880" + term_id: C6880 + term_version: 20.05a + +papillary_and_follicular_adenocarcinoma: + common: + description: >- + Thyroid Gland Papillary and Follicular Carcinoma + termDef: + term: >- + Thyroid Gland Papillary and Follicular Carcinoma + source: NCIt + cde_id: C7380 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7380 " + term_id: C7380 + term_version: 20.05a + +papillary_and_follicular_carcinoma: + common: + description: >- + Thyroid Gland Papillary and Follicular Carcinoma + termDef: + term: >- + Thyroid Gland Papillary and Follicular Carcinoma + source: NCIt + cde_id: C7380 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7380 " + term_id: C7380 + term_version: 20.05a + +papillary_carcinoma_columnar_cell: + common: + description: >- + A morphologic variant of papillary carcinoma of the thyroid gland characterized + by the presence of pseudostratified malignant follicular cells. + termDef: + term: >- + Columnar Cell Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C35830 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35830" + term_id: C35830 + term_version: 20.05a + +papillary_carcinoma_diffuse_sclerosing: + common: + description: >- + A morphologic variant of papillary carcinoma of the thyroid gland that more + often affects young patients and commonly metastasizing to the lungs. It is + characterized by a diffuse infiltration of the thyroid gland by malignant follicular + cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration. + termDef: + term: >- + Diffuse Sclerosing Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C7427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7427" + term_id: C7427 + term_version: 20.05a + +papillary_carcinoma_in_situ: + common: + description: >- + An epithelial neoplasm with a papillary growth pattern in which the malignant + cells are confined to the epithelium, without evidence of invasion. + termDef: + term: >- + Papillary Carcinoma In Situ + source: NCIt + cde_id: C65163 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65163 " + term_id: C65163 + term_version: 20.05a + +papillary_carcinoma_nos: + common: + description: >- + A malignant epithelial neoplasm characterized by a papillary growth pattern. + A papillary carcinoma may be composed of glandular cells (papillary adenocarcinoma), + squamous cells (papillary squamous cell carcinoma), or transitional cells (papillary + transitional cell carcinoma). Bladder carcinoma is a representative example + of papillary transitional cell carcinoma. + termDef: + term: >- + Papillary Carcinoma + source: NCIt + cde_id: C2927 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2927" + term_id: C2927 + term_version: 20.05a + +papillary_carcinoma_of_thyroid: + common: + description: >- + A differentiated adenocarcinoma arising from the follicular cells of the thyroid + gland. Radiation exposure is a risk factor and it is the most common malignant + thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient + countries. Diagnostic procedures include thyroid ultrasound and fine needle + biopsy. Microscopically, the diagnosis is based on the distinct characteristics + of the malignant cells, which include enlargement, oval shape, elongation, and + overlapping of the nuclei. The nuclei also display clearing or have a ground + glass appearance. + termDef: + term: >- + Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C4035 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4035" + term_id: C4035 + term_version: 20.05a + +papillary_carcinoma_tall_cell: + common: + description: >- + A morphologic variant of papillary carcinoma of the thyroid gland characterized + by the presence of tall malignant follicular cells, arranged in papillary and + trabecular patterns. Necrotic changes and high mitotic activity are present. + termDef: + term: >- + Tall Cell Variant Thyroid Gland Papillary Carcinoma + source: NCIt + cde_id: C35558 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35558" + term_id: C35558 + term_version: 20.05a + +papillary_cystadenocarcinoma_nos: + common: + description: >- + A malignant cystic serous or mucinous epithelial neoplasm characterized by the + presence of malignant glandular epithelial cells forming papillary structures. + Stromal invasion is present. + termDef: + term: >- + Papillary Cystadenocarcinoma + source: NCIt + cde_id: C3777 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3777" + term_id: C3777 + term_version: 20.05a + +papillary_cystadenoma_borderline_malignancy: + common: + description: >- + A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. + It is characterized by the presence of atypical or malignant glandular epithelial + cells forming papillary structures with an absence of stromal invasion. + termDef: + term: >- + Borderline Papillary Cystadenoma + source: NCIt + cde_id: C4178 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4178" + term_id: C4178 + term_version: 20.05a + +papillary_cystadenoma_lymphomatosum: + common: + description: >- + An adenoma characterized by an oncocytic, often papillary, epithelial component, + dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid + gland, and is the second most common benign parotid salivary gland tumor. A + strong association with smoking has been reported. It typically presents as + a painless swelling in the lower portion of the parotid gland. + termDef: + term: >- + Warthin Tumor + source: NCIt + cde_id: C2854 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2854" + term_id: C2854 + term_version: 20.05a + +papillary_cystadenoma_nos: + common: + description: >- + A serous or mucinous benign or low malignant potential cystic epithelial neoplasm. + It is characterized by the presence of glandular epithelial cells forming papillary + structures. + termDef: + term: >- + Papillary Cystadenoma + source: NCIt + cde_id: C2974 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2974" + term_id: C2974 + term_version: 20.05a + +papillary_cystic_tumor: + common: + description: >- + A benign, malignant, or borderline epithelial neoplasm characterized by the + presence of papillary mucinous, serous, or clear cell structures and cystic + structures. + termDef: + term: >- + Papillary Cystic Neoplasm + source: NCIt + cde_id: C4179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4179" + term_id: C4179 + term_version: 20.05a + +papillary_ependymoma: + common: + description: >- + A rare variant of ependymoma characterized by well formed papillae. Tumor cell + processes abutting capillaries are usually GFAP-positive. Differential diagnoses + include choroid plexus papilloma, papillary meningioma and metastatic papillary + carcinoma. (Adapted from WHO) + termDef: + term: >- + Papillary Ependymoma + source: NCIt + cde_id: C4319 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4319" + term_id: C4319 + term_version: 20.05a + +papillary_epidermoid_carcinoma: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary, + exophytic growth pattern and hyperkeratosis. The most commonly affected anatomic + sites are the larynx, penis, cervix, vagina, and vulva. + termDef: + term: >- + Papillary Squamous Cell Carcinoma + source: NCIt + cde_id: C4102 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4102" + term_id: C4102 + term_version: 20.05a + +papillary_glioneuronal_tumor: + common: + description: >- + A WHO grade I, indolent and relatively circumscribed brain tumor. Morphologically + it is characterized by the presence of astrocytes that line vascular and hyalinized + pseudopapillae. In between the pseudopapillae aggregates of neurocytes, large + neurons, and ganglioid cells are present. + termDef: + term: >- + Papillary Glioneuronal Tumor + source: NCIt + cde_id: C92554 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92554" + term_id: C92554 + term_version: 20.05a + +papillary_hidradenoma: + common: + description: >- + A benign neoplasm arising from the sweat glands. It presents as a slow growing + cystic nodular lesion most often in the skin of the vulva and the perianal region. + It is characterized by the presence of cystic and large papillary structures. + The papillary structures contain connective tissue and are covered by two layers + of epithelium. Complete excision is curative. + termDef: + term: >- + Hidradenoma Papilliferum + source: NCIt + cde_id: C4171 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4171" + term_id: C4171 + term_version: 20.05a + +papillary_meningioma: + common: + description: >- + A WHO grade III meningioma characterized by the predominance of a perivascular + pseudopapillary pattern. + termDef: + term: >- + Papillary Meningioma + source: NCIt + cde_id: C3904 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3904" + term_id: C3904 + term_version: 20.05a + +papillary_mucinous_cystadenocarcinoma: + common: + description: >- + An invasive adenocarcinoma characterized by cystic changes, papillary growth + pattern, and the presence of malignant glandular cells which contain intracytoplasmic + mucin. + termDef: + term: >- + Papillary Mucinous Cystadenocarcinoma + source: NCIt + cde_id: C65204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65204" + term_id: C65204 + term_version: 20.05a + +papillary_mucinous_cystadenoma_borderline_malignancy: + common: + description: >- + A low malignant potential cystic epithelial neoplasm usually arising from the + ovary. It is composed of glandular cells with intracytoplasmic mucin. It is + characterized by an atypical epithelial proliferation and a papillary growth + pattern. There is no evidence of destructive stromal invasion. + termDef: + term: >- + Borderline Papillary Mucinous Cystadenoma + source: NCIt + cde_id: C4186 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4186" + term_id: C4186 + term_version: 20.05a + +papillary_mucinous_cystadenoma_nos: + common: + description: >- + A usually benign and less often low malignant potential cystic epithelial neoplasm + composed of cells which contain intracytoplasmic mucin. It is characterized + by the presence of papillary structures. + termDef: + term: >- + Papillary Mucinous Cystadenoma + source: NCIt + cde_id: C4184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4184" + term_id: C4184 + term_version: 20.05a + +papillary_mucinous_tumor_of_low_malignant_potential: + common: + description: >- + A low malignant potential cystic epithelial neoplasm usually arising from the + ovary. It is composed of glandular cells with intracytoplasmic mucin. It is + characterized by an atypical epithelial proliferation and a papillary growth + pattern. There is no evidence of destructive stromal invasion. + termDef: + term: >- + Borderline Papillary Mucinous Cystadenoma + source: NCIt + cde_id: C4186 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4186" + term_id: C4186 + term_version: 20.05a + +papillary_neoplasm_pancreatobiliarytype_with_high_grade_intraepithelial_neoplasia: + common: + description: >- + An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized + by the presence of high grade dysplasia. + termDef: + term: >- + Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade + Dysplasia + source: NCIt + cde_id: C95915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95915" + term_id: C95915 + term_version: 20.05a + +papillary_nos: + common: + description: >- + A morphologic finding indicating the presence of a cellular infiltrate with + papillary growth in a tissue sample. + termDef: + term: >- + Papillary Pattern + source: NCIt + cde_id: C35911 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35911" + term_id: C35911 + term_version: 20.10d + +papillary_pseudomucinous_cystadenocarcinoma: + common: + description: >- + An invasive adenocarcinoma characterized by cystic changes, papillary growth + pattern, and the presence of malignant glandular cells which contain intracytoplasmic + mucin. + termDef: + term: >- + Papillary Mucinous Cystadenocarcinoma + source: NCIt + cde_id: C65204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65204" + term_id: C65204 + term_version: 20.05a + +papillary_pseudomucinous_cystadenoma_borderline_malignancy: + common: + description: >- + A low malignant potential cystic epithelial neoplasm usually arising from the + ovary. It is composed of glandular cells with intracytoplasmic mucin. It is + characterized by an atypical epithelial proliferation and a papillary growth + pattern. There is no evidence of destructive stromal invasion. + termDef: + term: >- + Borderline Papillary Mucinous Cystadenoma + source: NCIt + cde_id: C4186 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4186" + term_id: C4186 + term_version: 20.05a + +papillary_pseudomucinous_cystadenoma_nos: + common: + description: >- + A usually benign and less often low malignant potential cystic epithelial neoplasm + composed of cells which contain intracytoplasmic mucin. It is characterized + by the presence of papillary structures. + termDef: + term: >- + Papillary Mucinous Cystadenoma + source: NCIt + cde_id: C4184 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4184" + term_id: C4184 + term_version: 20.05a + +papillary_renal_cell: + common: + description: >- + Also known as chromophil carcinoma, it represents a minority of renal cell carcinomas. + It can be hereditary or sporadic. The sporadic papillary renal cell carcinoma + is characterized by trisomy of chromosomes 7, 16, and 17, and loss of chromosome + Y. The peak incidence is in the sixth and seven decades. It is classified as + type 1 or 2, based on the cytoplasmic volume and the thickness of the lining + neoplastic cells. The prognosis is more favorable than for conventional (clear + cell) renal cell carcinoma. + termDef: + term: >- + Papillary Renal Cell Carcinoma + source: NCIt + cde_id: C6975 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6975" + term_id: C6975 + term_version: 20.10d + +papillary_renal_cell_carcinoma: + common: + description: >- + Also known as chromophil carcinoma, it represents a minority of renal cell carcinomas. It + can be hereditary or sporadic. The sporadic papillary renal cell carcinoma + is characterized by trisomy of chromosomes 7, 16, and 17, and loss of chromosome + Y. The peak incidence is in the sixth and seven decades. It is classified + as type 1 or 2, based on the cytoplasmic volume and the thickness of the lining + neoplastic cells. The prognosis is more favorable than for conventional (clear + cell) renal cell carcinoma. + termDef: + term: >- + Papillary Renal Cell Carcinoma + source: NCIt + cde_id: C6975 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6975" + term_id: C6975 + term_version: 20.05a + +papillary_serous_adenocarcinoma: + common: + description: >- + A malignant cystic serous epithelial neoplasm characterized by the presence + of malignant glandular epithelial cells forming papillary structures. Stromal + invasion is present. + termDef: + term: >- + Papillary Serous Cystadenocarcinoma + source: NCIt + cde_id: C8377 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8377" + term_id: C8377 + term_version: 20.05a + +papillary_serous_cystadenocarcinoma: + common: + description: >- + A malignant cystic serous epithelial neoplasm characterized by the presence + of malignant glandular epithelial cells forming papillary structures. Stromal + invasion is present. + termDef: + term: >- + Papillary Serous Cystadenocarcinoma + source: NCIt + cde_id: C8377 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8377" + term_id: C8377 + term_version: 20.05a + +papillary_serous_cystadenoma_borderline_malignancy: + common: + description: >- + A low malignant potential cystic serous epithelial neoplasm arising from the + ovary. Cases with identical morphology have been described arising from the + peritoneum as well. It is characterized by an atypical epithelial proliferation + and a papillary growth pattern. There is no evidence of destructive stromal + invasion. + termDef: + term: >- + Borderline Papillary Serous Cystadenoma + source: NCIt + cde_id: C4183 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4183" + term_id: C4183 + term_version: 20.05a + +papillary_serous_cystadenoma_nos: + common: + description: >- + A serous benign or low malignant potential cystic epithelial neoplasm characterized + by the presence of glandular epithelial cells forming papillary structures. + termDef: + term: >- + Papillary Serous Cystadenoma + source: NCIt + cde_id: C4180 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4180" + term_id: C4180 + term_version: 20.05a + +papillary_serous_tumor_of_low_malignant_potential: + common: + description: >- + A low malignant potential cystic serous epithelial neoplasm arising from the + ovary. Cases with identical morphology have been described arising from the + peritoneum as well. It is characterized by an atypical epithelial proliferation + and a papillary growth pattern. There is no evidence of destructive stromal + invasion. + termDef: + term: >- + Borderline Papillary Serous Cystadenoma + source: NCIt + cde_id: C4183 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4183" + term_id: C4183 + term_version: 20.05a + +papillary_squamous_cell_carcinoma: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary, + exophytic growth pattern and hyperkeratosis. The most commonly affected anatomic + sites are the larynx, penis, cervix, vagina, and vulva. + termDef: + term: >- + Papillary Squamous Cell Carcinoma + source: NCIt + cde_id: C4102 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4102" + term_id: C4102 + term_version: 20.05a + +papillary_squamous_cell_carcinoma_in_situ: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary, + exophytic growth pattern, hyperkeratosis, and absence of invasion of adjacent + tissues. + termDef: + term: >- + Non-Invasive Papillary Squamous Cell Carcinoma + source: NCIt + cde_id: C65164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65164" + term_id: C65164 + term_version: 20.05a + +papillary_squamous_cell_carcinoma_noninvasive: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary, + exophytic growth pattern, hyperkeratosis, and absence of invasion of adjacent + tissues. + termDef: + term: >- + Non-Invasive Papillary Squamous Cell Carcinoma + source: NCIt + cde_id: C65164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65164" + term_id: C65164 + term_version: 20.05a + +papillary_syringadenoma: + common: + description: >- + A benign adnexal neoplasm occurring during childhood or adolescence. It usually + presents as a papular lesion or a plaque on the head and neck. It may arise + in an organoid nevus such as sebaceous. It is characterized by an endophytic + invagination of the epithelium into the dermis. There are dermal cystic spaces + present, containing villous projections. Complete excision is curative. + termDef: + term: >- + Syringocystadenoma Papilliferum + source: NCIt + cde_id: C4172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4172" + term_id: C4172 + term_version: 20.05a + +papillary_syringocystadenoma: + common: + description: >- + A benign adnexal neoplasm occurring during childhood or adolescence. It usually + presents as a papular lesion or a plaque on the head and neck. It may arise + in an organoid nevus such as sebaceous. It is characterized by an endophytic + invagination of the epithelium into the dermis. There are dermal cystic spaces + present, containing villous projections. Complete excision is curative. + termDef: + term: >- + Syringocystadenoma Papilliferum + source: NCIt + cde_id: C4172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4172" + term_id: C4172 + term_version: 20.05a + +papillary_transitional_cell_carcinoma: + common: + description: >- + A non-invasive or invasive transitional cell carcinoma characterized by a papillary + growth pattern. It may occur in the bladder or the renal pelvis. + termDef: + term: >- + Papillary Transitional Cell Carcinoma + source: NCIt + cde_id: C4122 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4122" + term_id: C4122 + term_version: 20.05a + +papillary_transitional_cell_carcinoma_noninvasive: + common: + description: >- + A transitional cell carcinoma characterized by a papillary growth pattern and + lack of stromal invasion. + termDef: + term: >- + Non-Invasive Papillary Transitional Cell Carcinoma + source: NCIt + cde_id: C65181 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65181" + term_id: C65181 + term_version: 20.05a + +papillary_transitional_cell_neoplasm_of_low_malignant_potential: + common: + description: >- + A papillary neoplasm of the urinary bladder in which the transitional cells + form papillae. The papillary structures exhibit minimal architectural distortion + and minimal atypia. Mitoses are infrequent. Patients are at an increased risk + of developing new papillary lesions. Occasionally, the new lesions are urothelial + carcinomas. + termDef: + term: >- + Bladder Papillary Urothelial Neoplasm of Low Malignant Potential + source: NCIt + cde_id: C27884 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27884" + term_id: C27884 + term_version: 20.05a + +papillary_tumor_of_the_pineal_region: + common: + description: >- + A rare tumor that arises from the pineal region and affects adults. It is characterized + by the presence of neuroepithelial cells and a papillary architecture. Electron + microscopic studies suggest ependymal differentiation. The clinical course + is variable. + termDef: + term: >- + Papillary Tumor of the Pineal Region + source: NCIt + cde_id: C92624 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92624" + term_id: C92624 + term_version: 20.05a + +papillary_urothelial_carcinoma: + common: + description: >- + A non-invasive or invasive transitional cell carcinoma characterized by a papillary + growth pattern. It may occur in the bladder or the renal pelvis. + termDef: + term: >- + Papillary Transitional Cell Carcinoma + source: NCIt + cde_id: C4122 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4122" + term_id: C4122 + term_version: 20.05a + +papillary_urothelial_carcinoma_noninvasive: + common: + description: >- + A transitional cell carcinoma characterized by a papillary growth pattern and + lack of stromal invasion. + termDef: + term: >- + Non-Invasive Papillary Transitional Cell Carcinoma + source: NCIt + cde_id: C65181 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65181" + term_id: C65181 + term_version: 20.05a + +papillary_urothelial_neoplasm_of_low_malignant_potential: + common: + description: >- + A papillary neoplasm of the urinary bladder in which the transitional cells + form papillae. The papillary structures exhibit minimal architectural distortion + and minimal atypia. Mitoses are infrequent. Patients are at an increased risk + of developing new papillary lesions. Occasionally, the new lesions are urothelial + carcinomas. + termDef: + term: >- + Bladder Papillary Urothelial Neoplasm of Low Malignant Potential + source: NCIt + cde_id: C27884 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27884" + term_id: C27884 + term_version: 20.05a + +papillocystic_adenocarcinoma: + common: + description: >- + A malignant cystic serous or mucinous epithelial neoplasm characterized by the + presence of malignant glandular epithelial cells forming papillary structures. + Stromal invasion is present. + termDef: + term: >- + Papillary Cystadenocarcinoma + source: NCIt + cde_id: C3777 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3777" + term_id: C3777 + term_version: 20.05a + +papilloma_nos: + common: + description: >- + A benign epithelial neoplasm that projects above the surrounding epithelial + surface and consists of villous or arborescent outgrowths of fibrovascular stroma. + termDef: + term: >- + Papilloma + source: NCIt + cde_id: C7440 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7440" + term_id: C7440 + term_version: 20.05a + +papilloma_of_bladder: + common: + description: >- + A rare benign condition, characterized by a papillary growth in the urinary + tract with a central fibrovascular core. The latter is lined by normal urothelium. + termDef: + term: >- + Urothelial Papilloma + source: NCIt + cde_id: C3842 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3842" + term_id: C3842 + term_version: 20.05a + +papillomatosis_glandular: + common: + description: >- + Multifocal neoplastic proliferations of the glandular epithelium displaying + a papillary pattern. + termDef: + term: >- + Glandular Papillomatosis + source: NCIt + cde_id: C65198 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65198" + term_id: C65198 + term_version: 20.05a + +papillomatosis_nos: + common: + description: >- + Glandular or squamous cell neoplastic proliferations characterized by the formation + of multiple papillary structures diffusely involving a specific anatomic site. + termDef: + term: >- + Papillomatosis + source: NCIt + cde_id: C3713 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3713" + term_id: C3713 + term_version: 20.05a + +papillotubular_adenoma: + common: + description: >- + An epithelial neoplasm morphologically characterized by the presence of a villous + and a tubular architectural pattern. Most often it occurs in the large intestine, + small intestine, and the stomach in which the neoplastic epithelial cells show + dysplastic features. + termDef: + term: >- + Tubulovillous Adenoma + source: NCIt + cde_id: C4143 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4143" + term_id: C4143 + term_version: 20.05a + +papua_new_guinea: + common: + description: >- + A country in southeastern Asia, comprising a group of islands and including + the eastern half of the island of New Guinea, between the Coral Sea and the + South Pacific Ocean, east of Indonesia. + termDef: + term: >- + Papua New Guinea + source: NCIt + cde_id: C16952 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16952" + term_id: C16952 + term_version: 19.12e + +paraaortic: + common: + description: >- + A lymph node located adjacent to the lumbar region of the spine. + termDef: + term: >- + Paraaortic Lymph Node + source: NCIt + cde_id: C77643 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77643" + term_id: C77643 + term_version: 20.10d + +parachordoma: + common: + description: >- + A rare, usually benign myoepithelial tumor characterized by the presence of + epithelioid, often vacuolated neoplastic cells. Most patients present with painless + swelling in the subcutaneous or subfascial soft tissues of the extremities. + termDef: + term: >- + Parachordoma + source: NCIt + cde_id: C6581 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6581" + term_id: C6581 + term_version: 20.05a + +parafollicular_cell_carcinoma: + common: + description: >- + A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It + is closely associated with multiple endocrine neoplasia syndromes. Approximately + 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present + with a thyroid nodule that is painless and firm. In the majority of cases nodal + involvement is present at diagnosis. Surgery is the preferred treatment for + both primary lesions and recurrences. This carcinoma is generally not very + sensitive to radiation and almost unresponsive to chemotherapy. + termDef: + term: >- + Thyroid Gland Medullary Carcinoma + source: NCIt + cde_id: C3879 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3879" + term_id: C3879 + term_version: 20.05a + +paraganglioma_benign: + common: + description: >- + A paraganglioma that is confined to the site of origin, without metastatic potential. + termDef: + term: >- + Benign Paraganglioma + source: NCIt + cde_id: C48314 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48314" + term_id: C48314 + term_version: 20.05a + +paraganglioma_malignant: + common: + description: >- + A paraganglioma that metastasizes to regional or distant anatomic sites. Extraadrenal + paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas. Common + sites of metastasis include the lymph nodes, lungs, bones, and liver. + termDef: + term: >- + Malignant Paraganglioma + source: NCIt + cde_id: C8559 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8559" + term_id: C8559 + term_version: 20.05a + +paraganglioma_nos: + common: + description: >- + A benign or malignant neoplasm arising from paraganglia located along the sympathetic + or parasympathetic nerves. Infrequently, it may arise outside the usual distribution + of the sympathetic and parasympathetic paraganglia. Tumors arising from the + adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas + usually display a nesting (Zellballen) growth pattern. There are no reliable + morphologic criteria to distinguish between benign and malignant paragangliomas. The + only definitive indicator of malignancy is the presence of regional or distant + metastases. + termDef: + term: >- + Paraganglioma + source: NCIt + cde_id: C3308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3308" + term_id: C3308 + term_version: 20.05a + +paraguay: + common: + description: >- + A country in central South America, northeast of Argentina. + termDef: + term: >- + Paraguay + source: NCIt + cde_id: C16953 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16953" + term_id: C16953 + term_version: 19.12e + +parametrium: + common: + description: >- + The subserous connective tissue of the pelvic floor of the supracervical portion + of the uterus. The parametrium extends laterally between the layers of the broad + ligament. + termDef: + term: >- + Parametrium + source: NCIt + cde_id: C12320 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12320" + term_id: C12320 + term_version: 20.05a + +parasympathetic_paraganglioma: + common: + description: >- + A benign or malignant, usually non-functioning, extra-adrenal paraganglioma + that arises from paraganglia located along the parasympathetic nerves. Representative + examples include aorticopulmonary, carotid body, jugulotympanic, and mediastinal + paragangliomas. + termDef: + term: >- + Parasympathetic Paraganglioma + source: NCIt + cde_id: C4217 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4217" + term_id: C4217 + term_version: 20.05a + +parathyroid_gland: + common: + description: >- + One of two small paired endocrine glands, superior and inferior, usually found + embedded in the connective tissue capsule on the posterior surface of the thyroid + gland; these glands secrete parathyroid hormone that regulates the metabolism + of calcium and phosphorus. The parenchyma is composed of chief and oxyphilic + cells arranged in anastomosing cords. + termDef: + term: >- + Parathyroid Gland + source: NCIt + cde_id: C12765 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12765" + term_id: C12765 + term_version: 20.05a + +paraurethral_gland: + common: + description: >- + A gland located in the anterior wall of the vagina that drains into the urethra + at the opening. + termDef: + term: >- + Skene Gland + source: NCIt + cde_id: C61122 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61122" + term_id: C61122 + term_version: 20.05a + +parent: + common: + description: >- + A mother or a father; an immediate progenitor. + termDef: + term: >- + Parent + source: NCIt + cde_id: C42709 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C42709" + term_id: C42709 + term_version: 19.12e + +parietal_cell_adenocarcinoma: + common: + description: >- + An adenocarcinoma of the stomach arising from the parietal cells. It is characterized + by the presence of malignant cells with eosinophilic, finely granular cytoplasm. + termDef: + term: >- + Gastric Parietal Cell Adenocarcinoma + source: NCIt + cde_id: C65194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65194" + term_id: C65194 + term_version: 20.05a + +parietal_cell_carcinoma: + common: + description: >- + An adenocarcinoma of the stomach arising from the parietal cells. It is characterized + by the presence of malignant cells with eosinophilic, finely granular cytoplasm. + termDef: + term: >- + Gastric Parietal Cell Adenocarcinoma + source: NCIt + cde_id: C65194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65194" + term_id: C65194 + term_version: 20.05a + +parietal_lobe: + common: + description: >- + One of the lobes of the cerebral hemisphere located superiorly to the occipital + lobe and posteriorly to the frontal lobe. Cognition and visuospatial processing + are its main functions. + termDef: + term: >- + Parietal Lobe + source: NCIt + cde_id: C12354 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12354" + term_id: C12354 + term_version: 20.05a + +parosteal_osteosarcoma: + common: + description: >- + A low grade malignant bone-forming mesenchymal neoplasm arising from the surface + of the bone. It usually affects the distal posterior femur, the proximal tibia, + and proximal humerus. Painless swelling is the usual clinical sign. Most patients + are young adults and the prognosis is usually excellent. + termDef: + term: >- + Parosteal Osteosarcoma + source: NCIt + cde_id: C8969 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8969" + term_id: C8969 + term_version: 20.05a + +parotid: + common: + description: >- + A lymph node located close to, on, or within the parotid gland. + termDef: + term: >- + Parotid Gland Lymph Node + source: NCIt + cde_id: C33278 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33278" + term_id: C33278 + term_version: 20.10d + +parotid_gland: + common: + description: >- + The largest of the three paired salivary glands, located in front of the ear. + termDef: + term: >- + Parotid Gland + source: NCIt + cde_id: C12427 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12427" + term_id: C12427 + term_version: 20.05a + +parp_12_inhibitor_imp4297: + common: + description: >- + An orally bioavailable inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase + (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, + PARP 1/2 inhibitor IMP4297 selectively binds to PARP 1 and 2 and prevents PARP-mediated + DNA repair of single-strand DNA breaks via the base-excision repair pathway. + This enhances the accumulation of DNA strand breaks and promotes genomic instability + and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation + of nuclear proteins that signal and recruit other proteins to repair damaged + DNA and is activated by single-strand DNA breaks. + termDef: + term: >- + PARP 1/2 Inhibitor IMP4297 + source: NCIt + cde_id: C168601 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168601" + term_id: C168601 + term_version: 20.10d + +parp_inhibitor_nms03305293: + common: + description: >- + An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase + (PARP) with potential antineoplastic activity. Upon administration, PARP inhibitor + NMS-03305293 selectively binds to PARP and prevents PARP-mediated DNA repair + of single-strand DNA breaks via the base-excision repair pathway. This enhances + the accumulation of DNA strand breaks and promotes genomic instability and eventually + leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear + proteins that signal and recruit other proteins to repair damaged DNA and is + activated by single-strand DNA breaks. + termDef: + term: >- + PARP Inhibitor NMS-03305293 + source: NCIt + cde_id: C167278 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167278" + term_id: C167278 + term_version: 20.10d + +parp7_inhibitor_rbn2397: + common: + description: >- + An orally available small molecule inhibitor of the nuclear enzyme poly (ADP-ribose) + polymerase (PARP) 7, with potential immunomodulating and antineoplastic activities. + Upon oral administration, PARP7 inhibitor RBN-2397 selectively binds to PARP7 + and restores interferon (type 1) signaling. This may lead to the induction + of both innate and adaptive immune responses, and the inhibition of tumor growth + and proliferation. PARP catalyzes post-translational ADP-ribosylation of nuclear + proteins that signal and recruit other proteins to repair damaged DNA. + termDef: + term: >- + PARP7 Inhibitor RBN-2397 + source: NCIt + cde_id: C170764 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170764" + term_id: C170764 + term_version: 20.10d + +parptankyrase_inhibitor_2x121: + common: + description: >- + An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) + polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, + E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged + DNA via the base excision repair (BER) pathway. This agent enhances the accumulation + of single and double strand DNA breaks and promotes genomic instability eventually + leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity + of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational + ADP-ribosylation of nuclear proteins that signal and recruit other proteins + to repair damaged DNA. + termDef: + term: >- + PARP/Tankyrase Inhibitor 2X-121 + source: NCIt + cde_id: C102746 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102746" + term_id: C102746 + term_version: 20.10d + +parsaclisib: + common: + description: >- + An inhibitor of the delta isoform of phosphoinositide-3 kinase (PI3K) with potential + antineoplastic activity. Parsaclisib inhibits the delta isoform of PI3K and + prevents the activation of the PI3K/AKT signaling pathway. This both decreases + proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. + Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic + disease and cell lineages. The targeted inhibition of PI3K-delta is designed + to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme + often overexpressed in cancer cells, plays a crucial role in tumor cell regulation + and survival. + termDef: + term: >- + Parsaclisib + source: NCIt + cde_id: C113434 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113434" + term_id: C113434 + term_version: 20.10d + +parsaclisib_hydrochloride: + common: + description: >- + The hydrochloride salt form of parsaclisib, an inhibitor of the delta isoform + of phosphoinositide-3 kinase (PI3K) with potential antineoplastic activity. + Parsaclisib inhibits the delta isoform of PI3K and prevents the activation of + the PI3K/AKT signaling pathway. This both decreases proliferation and induces + cell death in PI3K-delta-overexpressing tumor cells. Unlike other isoforms of + PI3K, PI3K-delta is expressed primarily in hematopoietic disease and cell lineages. + The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling + in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer + cells, plays a crucial role in tumor cell regulation and survival. + termDef: + term: >- + Parsaclisib Hydrochloride + source: NCIt + cde_id: C166387 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166387" + term_id: C166387 + term_version: 20.10d + +partial_hydatidiform_mole: + common: + description: >- + A gestational trophoblastic disorder characterized by the presence of an abnormal + fetus and two populations of chorionic villi: one population which is unremarkable + and a second one which shows hydropic changes. + termDef: + term: >- + Partial Hydatidiform Mole + source: NCIt + cde_id: C4293 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4293" + term_id: C4293 + term_version: 20.05a + +partial_methylation: + common: + description: >- + An indication that 10-90% of the CpG islands in a gene or gene promoter have + detectable methylation. + termDef: + term: >- + Partial DNA Methylation + source: NCIt + cde_id: C165231 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165231" + term_id: C165231 + term_version: 20.10d + +partially_engineered_tregulatory_cell_donor_graft_trgft201: + common: + description: >- + A T-regulatory (Treg) cell donor graft that has been partially engineered by + depleting all the T-cells and then enriching the graft with infusions of conventional + T-cells and Tregs with potential immunomodulating activity. Upon administration + of the partially engineered T-regulatory cell donor graft TRGFT-201 following + myeloablation, the allograft may induce tolerance in patients undergoing allogeneic + hematopoietic stem cell transplantation (AHSCT) as treatment for hematologic + malignancies. + termDef: + term: >- + Partially Engineered T-regulatory Cell Donor Graft TRGFT-201 + source: NCIt + cde_id: C167207 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167207" + term_id: C167207 + term_version: 20.10d + +paternal_aunt: + common: + description: >- + A female relative who is a sibling of the biological father, and who both share + a common ancestor. + termDef: + term: >- + Biological Paternal Aunt + source: NCIt + cde_id: C96581 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96581" + term_id: C96581 + term_version: 19.12e + +paternal_first_cousin: + common: + description: >- + A relative who is the offspring of a sibling of the biological father and thus + sharing a common ancestor. + termDef: + term: >- + Biological Paternal Cousin + source: NCIt + cde_id: C96582 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96582" + term_id: C96582 + term_version: 19.12e + +paternal_first_cousin_once_removed: + common: + description: >- + A child of one's first cousin who is related by lineage through the father's + side of the family. + termDef: + term: >- + Paternal First Cousin Once Removed + source: NCIt + cde_id: C165852 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165852" + term_id: C165852 + term_version: 19.12e + +paternal_grandfather: + common: + description: >- + A male relative who is the biological father of the biological father. + termDef: + term: >- + Biological Paternal Grandfather + source: NCIt + cde_id: C96583 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96583" + term_id: C96583 + term_version: 19.12e + +paternal_grandmother: + common: + description: >- + A female relative who is the biological mother of the biological father. + termDef: + term: >- + Biological Paternal Grandmother + source: NCIt + cde_id: C96584 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96584" + term_id: C96584 + term_version: 19.12e + +paternal_grandparent: + common: + description: >- + A relative who is the biological parent of the biological father. + termDef: + term: >- + Biological Paternal Grandparent + source: NCIt + cde_id: C111286 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111286" + term_id: C111286 + term_version: 19.12e + +paternal_great_aunt: + common: + description: >- + The aunt of one's father. + termDef: + term: >- + Paternal Great Aunt + source: NCIt + cde_id: C165856 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165856" + term_id: C165856 + term_version: 19.12e + +paternal_great_grandparent: + common: + description: >- + A parent of one's paternal grandparent. + termDef: + term: >- + Paternal Great Grandparent + source: NCIt + cde_id: C166128 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166128" + term_id: C166128 + term_version: 19.12e + +paternal_great_uncle: + common: + description: >- + The uncle of one's father. + termDef: + term: >- + Paternal Great Uncle + source: NCIt + cde_id: C165857 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165857" + term_id: C165857 + term_version: 19.12e + +paternal_half_brother: + common: + description: >- + A male sibling who shares the genetic makeup inherited from only the biological + father. + termDef: + term: >- + Half-brother with Father as Common Parent + source: NCIt + cde_id: C96655 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96655" + term_id: C96655 + term_version: 19.12e + +paternal_half_sibling: + common: + description: >- + A relative with whom you share a biological father but you have different mothers. + termDef: + term: >- + Paternal Half Sibling + source: NCIt + cde_id: C166113 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166113" + term_id: C166113 + term_version: 19.12e + +paternal_half_sister: + common: + description: >- + A female sibling who shares the genetic makeup inherited from only the biological + father. + termDef: + term: >- + Half-sister with Father as Common Parent + source: NCIt + cde_id: C96657 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96657" + term_id: C96657 + term_version: 19.12e + +paternal_uncle: + common: + description: >- + A male relative who is a sibling of the biological father, and who both share + a common ancestor. + termDef: + term: >- + Biological Paternal Uncle + source: NCIt + cde_id: C96585 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96585" + term_id: C96585 + term_version: 19.12e + +pathogenic: + common: + description: >- + A genetic variant that is known to directly contribute to the development of + disease. + termDef: + term: >- + Pathogenic Variant + source: NCIt + cde_id: C168799 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168799" + term_id: C168799 + term_version: 20.10d + +pathologic_review: + common: + description: >- + An assessment of disease process to include cause, development, and/or structural + and functional changes associated with the disease. + termDef: + term: >- + Pathologic Examination + source: NCIt + cde_id: C125006 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125006" + term_id: C125006 + term_version: 20.05a + +patritumab_deruxtecan: + common: + description: >- + An antibody-drug conjugate (ADC) composed of patritumab, a monoclonal antibody + directed against the human epidermal growth factor receptor HER3 (ErbB3),linked + to the topoisomerase I inhibitor DX 8951, a semisynthetic, water-soluble derivative + of camptothecin, with potential antineoplastic activity. Upon administration + of patritumab deruxtecan, the patritumab moiety targets and binds to HER3. After + internalization, DX 8951 inhibits topoisomerase I activity by stabilizing the + complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, + thereby inhibiting DNA replication and triggering apoptotic cell death. HER3, + a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine + kinases, is frequently overexpressed in tumors. + termDef: + term: >- + Patritumab Deruxtecan + source: NCIt + cde_id: C136987 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C136987" + term_id: C136987 + term_version: 20.10d + +pattern_1: + common: + description: >- + A pattern of prostate carcinoma characterized by the presence of a well circumscribed + nodule of separate glands which are closely packed. There is no infiltration + of the surrounding parenchyma. The epithelial polarity of the malignant cells + is preserved and luminal differentiation is present in all glands. + termDef: + term: >- + Gleason Pattern 1 + source: NCIt + cde_id: C28085 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28085" + term_id: C28085 + term_version: 20.05a + +pattern_2: + common: + description: >- + A pattern of prostate carcinoma characterized by the presence of glands that + are more loosely arranged and less uniform compared to Gleason pattern 1. Minimal + invasion of the surrounding parenchyma may be present. The epithelial polarity + of the malignant cells is preserved and luminal differentiation is present in + all glands. + termDef: + term: >- + Gleason Pattern 2 + source: NCIt + cde_id: C28086 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28086" + term_id: C28086 + term_version: 20.05a + +pattern_3: + common: + description: >- + A pattern of prostate carcinoma characterized by the presence of glands that + are infiltrative and vary in size and shape. The epithelial polarity of the + malignant cells is preserved and luminal differentiation is present in all glands. + termDef: + term: >- + Gleason Pattern 3 + source: NCIt + cde_id: C28087 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28087" + term_id: C28087 + term_version: 20.05a + +pattern_4: + common: + description: >- + A pattern of prostate carcinoma characterized by the presence of fused, cribriform, + or poorly defined glands. There is partial loss of normal epithelial polarity. + termDef: + term: >- + Gleason Pattern 4 + source: NCIt + cde_id: C28088 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28088" + term_id: C28088 + term_version: 20.05a + +pattern_5: + common: + description: >- + A pattern of prostate carcinoma characterized by almost complete loss of epithelial + polarity and luminal differentiation. + termDef: + term: >- + Gleason Pattern 5 + source: NCIt + cde_id: C28089 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28089" + term_id: C28089 + term_version: 20.05a + +patz1: + common: + description: >- + This gene is involved in transcriptional regulation. + termDef: + term: >- + PATZ1 Gene + source: NCIt + cde_id: C97876 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97876" + term_id: C97876 + term_version: 20.10d + +pax3: + common: + description: >- + This gene plays a role in the transcriptional activation of target genes. It + is involved in melanogenesis, neurogenesis and skeletal muscle development. + termDef: + term: >- + PAX3 Gene + source: NCIt + cde_id: C24658 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24658" + term_id: C24658 + term_version: 20.10d + +pax5: + common: + description: >- + This gene is involved in the transcriptional regulation of target genes. It + plays a role in B-cell differentiation, neural development and spermatogenesis. + termDef: + term: >- + PAX5 Gene + source: NCIt + cde_id: C24659 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24659" + term_id: C24659 + term_version: 20.10d + +pax7: + common: + description: >- + This gene plays a role in the transcriptional regulation of target genes. It + is involved in pattern formation during embryogenesis. + termDef: + term: >- + PAX7 Gene + source: NCIt + cde_id: C24660 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24660" + term_id: C24660 + term_version: 20.10d + +pax8: + common: + description: >- + This gene is involved in thyroid development and transcriptional regulation. + termDef: + term: >- + PAX8 Gene + source: NCIt + cde_id: C97687 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97687" + term_id: C97687 + term_version: 20.10d + +paxalisib: + common: + description: >- + A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic + activity. paxalisib specifically inhibits PI3K in the PI3K/AKT kinase (or protein + kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling + pathway. This may result in the inhibition of both cell growth and survival + in susceptible tumor cell populations. Activation of the PI3K signaling pathway + is frequently associated with tumorigenesis. Dysregulated PI3K signaling may + contribute to tumor resistance to a variety of antineoplastic agents. + termDef: + term: >- + Paxalisib + source: NCIt + cde_id: C116877 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116877" + term_id: C116877 + term_version: 20.10d + +pbpalliative_benefit: + common: + description: >- + Any action or response, without curative intent, that mitigates some or all + of the unpleasant effects of a disease or condition. + termDef: + term: >- + Palliative + source: NCIt + cde_id: C101516 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101516" + term_id: C101516 + term_version: 20.05a + +pbrm1: + common: + description: >- + This gene plays a role in chromatin remodeling. + termDef: + term: >- + PBRM1 Gene + source: NCIt + cde_id: C95438 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95438" + term_id: C95438 + term_version: 20.10d + +pbx1: + common: + description: >- + This gene plays a role in the modulation of transcription. + termDef: + term: >- + PBX1 Gene + source: NCIt + cde_id: C97317 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97317" + term_id: C97317 + term_version: 20.10d + +pcbp1: + common: + description: >- + This gene plays a role in RNA splicing. + termDef: + term: >- + PCBP1 Gene + source: NCIt + cde_id: C95865 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95865" + term_id: C95865 + term_version: 20.10d + +pcm1: + common: + description: >- + This gene is involved in centrosome formation. + termDef: + term: >- + PCM1 Gene + source: NCIt + cde_id: C97900 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97900" + term_id: C97900 + term_version: 20.10d + +pcr: + common: + description: >- + A method for amplifying a DNA base sequence using multiple rounds of heat denaturation + of the DNA and annealing of oligonucleotide primers complementary to flanking + regions in the presence of a heat-stable polymerase. This results in duplication + of the targeted DNA region. Newly synthesized DNA strands can subsequently serve + as additional templates for the same primer sequences, so that successive rounds + of primer annealing, strand elongation, and dissociation produce rapid and highly + specific amplification of the desired sequence. PCR also can be used to detect + the existence of the defined sequence in a DNA sample. + termDef: + term: >- + Polymerase Chain Reaction + source: NCIt + cde_id: C17003 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17003" + term_id: C17003 + term_version: 20.10d + +pdcd1lg2: + common: + description: >- + This gene plays a role in the regulation of T-cell proliferation. + termDef: + term: >- + PDCD1LG2 Gene + source: NCIt + cde_id: C45437 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45437" + term_id: C45437 + term_version: 20.10d + +pde4dip: + common: + description: >- + This gene plays a role in protein complex localization. + termDef: + term: >- + PDE4DIP Gene + source: NCIt + cde_id: C97718 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97718" + term_id: C97718 + term_version: 20.10d + +pdgfb: + common: + description: >- + This gene is involved in cellular growth and proliferation. It is also plays + a role in intercellular signaling. + termDef: + term: >- + PDGFB Gene + source: NCIt + cde_id: C18278 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18278" + term_id: C18278 + term_version: 20.10d + +pdgfra: + common: + description: >- + This gene plays a role in mitogenic activities affecting mesenchymal cells and + is involved in receptor tyrosine kinase signal transduction. + termDef: + term: >- + PDGFRA Gene + source: NCIt + cde_id: C24666 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24666" + term_id: C24666 + term_version: 20.10d + +pdgfrb: + common: + description: >- + This gene plays a role in mitogenic activities affecting mesenchymal cells and + a translocation in the gene results in chronic myelomonocytic leukemia. + termDef: + term: >- + PDGFRB Gene + source: NCIt + cde_id: C24667 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24667" + term_id: C24667 + term_version: 20.10d + +pdl1_inhibitor_gs4224: + common: + description: >- + An orally available, small molecule inhibitor of the immunosuppressive ligand + programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), + with potential immune checkpoint inhibitory, anti-viral and antineoplastic activities. + Upon administration, PD-L1 inhibitor GS-4224 specifically targets PD-L1 expressed + on tumor cells preventing the binding and subsequent activation of its receptor, + programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses + T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell expansion + and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response + against PD-L1-expressing tumor cells. It may also enhance hepatitis B virus + (HBV)-specific CD8+ T-cell function, thereby killing HBV-infected cells. PD-L1, + a transmembrane protein expressed on activated T-cells, is overexpressed in + some cancer types and plays a significant role in immune evasion by tumor cells. + It is also upregulated in HBV-positive patients and contributes to immune dysfunction + against HBV infection. + termDef: + term: >- + PD-L1 Inhibitor GS-4224 + source: NCIt + cde_id: C170900 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170900" + term_id: C170900 + term_version: 20.10d + +pdl141bbhsa_trispecific_fusion_protein_nm211480: + common: + description: >- + A recombinant, trispecific monovalent antibody-based molecule targeting the + human programmed death-ligand 1 (PD-L1), 4-1BB (CD137; tumor necrosis factor + receptor superfamily member 9; TNFRSF9) and human serum albumin (HSA), with + potential checkpoint inhibitory, immunostimulating and antineoplastic activities. + PD-L1/4-1BB/HSA trispecific fusion protein NM21-1480 consists of three monovalent + antibody Fvs specific for PD-L1, HSA and 4-1BB fused in a single chain. Upon + administration, PD-L1/4-1BB/HSA trispecific fusion protein NM21-1480 simultaneously + targets and binds to a membrane-distal epitope of 4-1BB, which is expressed + on a variety of leukocyte subsets including activated T-lymphocytes, and PD-L1 + expressed on tumor cells. The simultaneous binding to PD-L1 enables clustering + of 4-1BB and thereby allows for conditional stimulation of 4-1BB signaling in + the tumor microenvironment (TME) only upon binding to PD-L1 on tumor cells. + 4-1BB activation results in T-cell stimulation and enhances T-lymphocyte-mediated + anti-tumor activity. At the same time, NM21-1480 prevents PD-L1 from binding + to and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; + programmed death-1). This abrogates T-cell inhibition, activates antigen-specific + T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which + may lead to a reduction in tumor growth. PD-L1 binding to PD-1 on activated + T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses + the immune system and results in immune evasion. 4-1BB, a surface glycoprotein + of the tumor necrosis factor receptor superfamily, is an inducible costimulatory + receptor that plays a key role in T-cell proliferation, survival and cytolytic + activity. HSA fusion prolongs the half-life of NM21-1480. The conditional activation + of 4-1BB signaling prevents systemic T-cell activation and lowers toxicity. + termDef: + term: >- + PD-L1/4-1BB/HSA Trispecific Fusion Protein NM21-1480 + source: NCIt + cde_id: C174020 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174020" + term_id: C174020 + term_version: 20.10d + +pdprogressive_disease: + common: + description: >- + Any action or response, without curative intent, that mitigates some or all + of the unpleasant effects of a disease or condition. + termDef: + term: >- + Progressive Neoplastic Disease + source: NCIt + cde_id: C8510 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8510" + term_id: C8510 + term_version: 20.05a + +pecoma_malignant: + common: + description: >- + A usually large and aggressive tumor with perivascular epithelioid cell differentiation + characterized by the presence of marked nuclear atypia, pleomorphism, increased + mitotic activity, necrosis, and infiltrative margins. The most common metastatic + sites are liver, lungs, lymph nodes, and bone. + termDef: + term: >- + Malignant PEComa + source: NCIt + cde_id: C121792 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121792" + term_id: C121792 + term_version: 20.05a + +pediatric_liver_cancer: + common: + description: >- + A malignant neoplasm of the liver developed in childhood. Representative examples + include hepatoblastoma, undifferentiated (embryonal) sarcoma, and extrarenal + rhabdoid tumor. + termDef: + term: >- + Childhood Malignant Liver Neoplasm + source: NCIt + cde_id: C7708 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7708" + term_id: C7708 + term_version: 19.12e + +pegvorhyaluronidase_alfa: + common: + description: >- + A pegylated formulation of a recombinant form of human hyaluronidase with potential + antitumor activity. Upon intravenous administration, pegvorhyaluronidase alfa + degrades hyaluronic acid (HA) coating tumor cells, which may result in the inhibition + of tumor cell growth. In addition, the degradation of HA may result in a lowering + of the interstitial fluid pressure (IFP), allowing better penetration of chemotherapeutic + agents into the tumor bed. HA is a glycosaminoglycan found in the extracellular + matrix (ECM) that is frequently overproduced by various tumor cell types. The + presence of HA in tumors correlates with increased tumor cell growth, metastatic + potential, tumor progression, increased resistance to chemotherapeutic agents, + and an elevation in tumor IFP. + termDef: + term: >- + Pegvorhyaluronidase Alfa + source: NCIt + cde_id: C82659 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82659" + term_id: C82659 + term_version: 20.10d + +pegylated_sn38_conjugate_plx038: + common: + description: >- + A pegylated conjugate of SN-38 (7-ethyl-10-hydroxy-camptothecin), a biologically + active metabolite of the prodrug irinotecan, with potential antineoplastic activity. + Upon administration, the proprietary linker slowly releases SN-38 from the pegylated + SN-38 conjugate PLX038. SN-38 binds to and inhibits topoisomerase I by stabilizing + the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, + inhibition of DNA replication, and apoptosis. Compared with irinotecan, this + formulation allows higher accumulation in solid tumors due to its nanoparticle + size and long half-life. + termDef: + term: >- + Pegylated SN-38 Conjugate PLX038 + source: NCIt + cde_id: C167334 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167334" + term_id: C167334 + term_version: 20.10d + +pelabresib: + common: + description: >- + A small molecule inhibitor of the Bromodomain and Extra-Terminal (BET) family + of proteins, with potential antineoplastic activity. Upon administration, pelabresib + binds to the acetylated lysine recognition motifs on the bromodomain of BET + proteins, thereby preventing the interaction between the BET proteins and acetylated + histone peptides. This disrupts chromatin remodeling and gene expression. Prevention + of the expression of certain growth-promoting genes may lead to an inhibition + of tumor cell growth. Characterized by a tandem repeat of two bromodomains at + the N-terminus, the BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional + regulators that play an important role during development and cellular growth. + termDef: + term: >- + Pelabresib + source: NCIt + cde_id: C111901 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111901" + term_id: C111901 + term_version: 20.10d + +pelvic_lymph_nodes: + common: + description: >- + Any lymph node within the abdominal pelvic region. + termDef: + term: >- + Pelvic Lymph Node + source: NCIt + cde_id: C12363 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12363" + term_id: C12363 + term_version: 20.05a + +pelvis: + common: + description: >- + The bony, basin-shaped structure formed by the hipbones and the base of the + backbone supporting the lower limbs in humans. + termDef: + term: >- + Pelvis + source: NCIt + cde_id: C12767 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12767" + term_id: C12767 + term_version: 20.05a + +pelvis_nos: + common: + description: >- + The bony, basin-shaped structure formed by the hipbones and the base of the + backbone supporting the lower limbs in humans. + termDef: + term: >- + Pelvis + source: NCIt + cde_id: C12767 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12767" + term_id: C12767 + term_version: 20.05a + +penis_nos: + common: + description: >- + The male organ of urination and copulation. + termDef: + term: >- + Penis + source: NCIt + cde_id: C12409 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12409" + term_id: C12409 + term_version: 20.05a + +peposertib: + common: + description: >- + An orally bioavailable inhibitor of DNA-dependent protein kinase (DNA-PK) with + potential antineoplastic activity, and potential sensitizing and enhancing activities + for both chemo- and radiotherapies. Upon administration, peposertib binds to + and inhibits the activity of DNA-PK, thereby interfering with the non-homologous + end joining (NHEJ) process and preventing repair of DNA double strand breaks + (DSBs) caused by ionizing radiation or chemotherapeutic treatment. This increases + chemo- and radiotherapy cytotoxicity and leads to enhanced tumor cell death. + The enhanced ability of tumor cells to repair DSBs plays a major role in the + resistance of tumor cells to chemo- and radiotherapy; DNA-PK plays a key role + in the NHEJ pathway and DSB repair. + termDef: + term: >- + Peposertib + source: NCIt + cde_id: C120036 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C120036" + term_id: C120036 + term_version: 20.10d + +per1: + common: + description: >- + This gene is involved in circadian rhythm. + termDef: + term: >- + PER1 Gene + source: NCIt + cde_id: C97721 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97721" + term_id: C97721 + term_version: 20.10d + +periapical_cemental_dysplasia: + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the jaw. It is a well-circumscribed + lytic tumor that varies in size. The cell of origin is the cementoblast. + termDef: + term: >- + Cementoblastoma + source: NCIt + cde_id: C4308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4308" + term_id: C4308 + term_version: 20.05a + +periapical_cementoosseous_dysplasia: + common: + description: >- + A rare benign bone-forming neoplasm usually arising from the jaw. It is a well-circumscribed + lytic tumor that varies in size. The cell of origin is the cementoblast. + termDef: + term: >- + Cementoblastoma + source: NCIt + cde_id: C4308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4308" + term_id: C4308 + term_version: 20.05a + +pericanalicular_fibroadenoma: + common: + description: >- + A morphologic variant of breast fibroadenoma without clinical significance. + It is characterized by circumferential proliferation of stromal cells around + the ducts. This results in the formation of rounded ductal-epithelial structures. + termDef: + term: >- + Breast Pericanalicular Fibroadenoma + source: NCIt + cde_id: C4272 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4272" + term_id: C4272 + term_version: 20.05a + +perifollicular_fibroma: + common: + description: >- + A benign neoplasm characterized by the presence of spindle-shaped fibroblasts + surrounding the hair follicle. + termDef: + term: >- + Perifollicular Fibroma + source: NCIt + cde_id: C4470 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4470" + term_id: C4470 + term_version: 20.05a + +perineural_mpnst: + common: + description: >- + A very rare malignant tumor with morphologic features similar to those of benign + perineurioma of soft tissue along with hypercellularity, nuclear atypia, hyperchromasia, + and a high mitotic rate. + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor with Perineurial Differentiation + source: NCIt + cde_id: C66845 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66845" + term_id: C66845 + term_version: 20.05a + +perineurioma_malignant: + common: + description: >- + A very rare malignant tumor with morphologic features similar to those of benign + perineurioma of soft tissue along with hypercellularity, nuclear atypia, hyperchromasia, + and a high mitotic rate. + termDef: + term: >- + Malignant Peripheral Nerve Sheath Tumor with Perineurial Differentiation + source: NCIt + cde_id: C66845 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66845" + term_id: C66845 + term_version: 20.05a + +perineurioma_nos: + common: + description: >- + A rare benign tumor composed entirely of neoplastic perineurial cells. It may + occur in the soft tissues, intraneurally or in mucosal sites. + termDef: + term: >- + Perineurioma + source: NCIt + cde_id: C4973 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4973" + term_id: C4973 + term_version: 20.05a + +periosteal_chondroma: + common: + description: >- + A benign neoplasm of bone surface composed of hyaline cartilage. It arises + beneath the periosteum and is characterized by the presence of chondrocytes, + a lobulated growth pattern, and calcification. + termDef: + term: >- + Periosteal Chondroma + source: NCIt + cde_id: C4302 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4302" + term_id: C4302 + term_version: 20.05a + +periosteal_chondrosarcoma: + common: + description: >- + A chondrosarcoma arising from the surface of bone. It is characterized by a + lobulated growth pattern, high mitotic activity, myxoid stroma formation, and + necrotic changes. It occurs in adults. Clinical presentation includes pain, + and sometimes swelling. + termDef: + term: >- + Periosteal Chondrosarcoma + source: NCIt + cde_id: C7357 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7357" + term_id: C7357 + term_version: 20.05a + +periosteal_fibroma: + common: + description: >- + A benign fibrous neoplasm arising from the periosteal connective tissue that + surrounds a bone. + termDef: + term: >- + Periosteal Fibroma + source: NCIt + cde_id: C66761 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66761" + term_id: C66761 + term_version: 20.05a + +periosteal_fibrosarcoma: + common: + description: >- + A malignant fibroblastic tumor arising from the periosteal connective tissue + that surrounds a bone. + termDef: + term: >- + Periosteal Fibrosarcoma + source: NCIt + cde_id: C66763 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66763" + term_id: C66763 + term_version: 20.05a + +periosteal_osteosarcoma: + common: + description: >- + An intermediate grade malignant bone-forming mesenchymal neoplasm with chondroblastic + differentiation. It arises from the surface of the bone and affects the diaphysis + or diaphyseal- metaphyseal portion of the long bones. A painless mass or swelling + is the most common clinical sign. It is associated with a better prognosis + than conventional osteosarcoma. + termDef: + term: >- + Periosteal Osteosarcoma + source: NCIt + cde_id: C8970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8970" + term_id: C8970 + term_version: 20.05a + +peripheral_neuroectodermal_tumor: + common: + description: >- + A small round cell tumor with neural differentiation arising from the soft tissues + or bone. + termDef: + term: >- + Peripheral Primitive Neuroectodermal Tumor + source: NCIt + cde_id: C9341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9341" + term_id: C9341 + term_version: 20.05a + +peripheral_odontogenic_fibroma: + common: + description: >- + A rare, benign, extraosseous neoplasm arising from tooth-forming tissues. It + usually presents as a slow growing exophytic mass in the gingiva. It is characterized + by the presence of odontogenic epithelium which is embedded in a fibrous stroma. + termDef: + term: >- + Peripheral Odontogenic Fibroma + source: NCIt + cde_id: C4315 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4315" + term_id: C4315 + term_version: 20.05a + +peripheral_primitive_neuroectodermal_tumor_nos: + common: + description: >- + A small round cell tumor with neural differentiation arising from the soft tissues + or bone. + termDef: + term: >- + Peripheral Primitive Neuroectodermal Tumor + source: NCIt + cde_id: C9341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9341" + term_id: C9341 + term_version: 20.05a + +peripheral_tcell_lymphoma_aild_angioimmunoblastic_lymphadenopathy_with_dysproteinemia: + common: + description: >- + A peripheral T-cell lymphoma of mature T follicular helper (TFH) cells characterized + by systemic disease and a polymorphous infiltrate involving lymph nodes, with + a prominent proliferation of high endothelial venules and follicular dendritic + cells. EBV-positive cells are nearly always present. It is a clinically aggressive + lymphoma and seen mainly in older adults. (WHO 2017) + termDef: + term: >- + Angioimmunoblastic T-Cell Lymphoma + source: NCIt + cde_id: C7528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7528" + term_id: C7528 + term_version: 20.05a + +peripheral_tcell_lymphoma_large_cell: + common: + description: >- + Peripheral T-Cell Lymphoma, Large Cell + termDef: + term: >- + Peripheral T-Cell Lymphoma, Large Cell + source: NCIt + cde_id: C27352 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27352" + term_id: C27352 + term_version: 20.05a + +peripheral_tcell_lymphoma_nos: + common: + description: >- + A heterogenous category of nodal and extranodal mature T-cell lymphomas that + do not correspond to any of the specifically defined entities of mature T-cell + lymphoma in the 2017 WHO classification. Excluded from this category are tumors + with a T follicular helper (TFH) cell phenotype. Variants include lymphoepithelioid + lymphoma (Lennert lymphoma) and primary EBV-positive nodal T-cell or NK-cell + lymphoma. The follicular variant included in the peripheral T-cell lymphomas, + not otherwise specified, in the 2008 edition of the WHO classification has been + moved to the category of angioimmunoblastic T-cell lymphoma and other nodal + lymphomas of T follicular helper cell origin in the 2017 WHO update. The same + is true for a proportion of cases previously designated as the T-zone variant, + because they usually have a TFH-cell phenotype. (WHO 2017) + termDef: + term: >- + Peripheral T-Cell Lymphoma, Not Otherwise Specified + source: NCIt + cde_id: C4340 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4340 " + term_id: C4340 + term_version: 20.05a + +peritoneal_cavity: + common: + description: >- + The lower part of the abdomen that contains the intestines (the last part of + the digestive tract), the stomach, and the liver. It is bound by thin membranes. + termDef: + term: >- + Peritoneal Cavity + source: NCIt + cde_id: C12769 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12769" + term_id: C12769 + term_version: 20.05a + +peritoneal_fluid: + common: + description: >- + The small amount of fluid that is generated in the abdominal cavity to lubricate + the peritoneum. + termDef: + term: >- + Peritoneal Fluid + source: NCIt + cde_id: C77612 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77612" + term_id: C77612 + term_version: 20.10d + +peritoneum: + common: + description: >- + The tissue that lines the wall of the abdominal cavity, intestine, mesentery, + and pelvic organs. It consists of the parietal peritoneum and the visceral peritoneum. + termDef: + term: >- + Peritoneum + source: NCIt + cde_id: C12770 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12770" + term_id: C12770 + term_version: 20.05a + +peritoneum_nos: + common: + description: >- + The tissue that lines the wall of the abdominal cavity, intestine, mesentery, + and pelvic organs. It consists of the parietal peritoneum and the visceral peritoneum. + termDef: + term: >- + Peritoneum + source: NCIt + cde_id: C12770 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12770" + term_id: C12770 + term_version: 20.05a + +perivascular_epithelioid_cell_tumor_malignant: + common: + description: >- + A usually large and aggressive tumor with perivascular epithelioid cell differentiation + characterized by the presence of marked nuclear atypia, pleomorphism, increased + mitotic activity, necrosis, and infiltrative margins. The most common metastatic + sites are liver, lungs, lymph nodes, and bone. + termDef: + term: >- + Malignant PEComa + source: NCIt + cde_id: C121792 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121792" + term_id: C121792 + term_version: 20.05a + +personalized_and_adjusted_neoantigen_peptide_vaccine_pandavac: + common: + description: >- + A peptide-based, personalized cancer therapeutic vaccine consisting of up to + 8 patient-specific tumor peptides, which are immunogenic and unique to the patient's + tumor and identified through DNA and RNA sequencing of a patient's tumor cells, + combined with the immunostimulant polyinosinic-polycytidylic acid stabilized + with polylysine and carboxymethylcellulose (poly-ICLC), with potential immunomodulating + and antineoplastic activities. Upon administration, personalized and adjusted + neoantigen peptide vaccine PANDA-VAC stimulates the host immune system to mount + a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, + leading to tumor cell lysis. The adjuvant poly-ICLC is a ligand for toll-like + receptor-3 (TLR3) and induces the release of cytokines which may help to boost + the immune response against the selected neoantigens. The vaccine may be adjusted + after initial therapy according to sequencing data. + termDef: + term: >- + Personalized and Adjusted Neoantigen Peptide Vaccine PANDA-VAC + source: NCIt + cde_id: C173152 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173152" + term_id: C173152 + term_version: 20.10d + +personalized_neoantigen_dna_vaccine_gnospv01: + common: + description: >- + A personalized cancer vaccine consisting of patient-specific neoantigen-coding + DNA plasmids, which are immunogenic and unique to the patient's tumor, with + potential immunomodulating and antineoplastic activities. Upon administration + of GNOS-PV01, the patient-specific neoantigens are translated in cells and elicit + a specific and potent cytotoxic T-lymphocyte (CTL) response against tumor cells + expressing these neoantigens, resulting in tumor cell lysis. Each patient specific + formulation may contain multiple DNA plasmids, and each plasmid may contain + multiple neoantigen DNA sequences, allowing the delivery of multiple neoantigen + DNA sequences simultaneously. + termDef: + term: >- + Personalized Neoantigen DNA Vaccine GNOS-PV01 + source: NCIt + cde_id: C171430 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171430" + term_id: C171430 + term_version: 20.10d + +personalized_neoantigen_dna_vaccine_gnospvo2: + common: + description: >- + A personalized cancer vaccine consisting of patient-specific neoantigen-coding + DNA plasmids, which are immunogenic and unique to the patient's tumor, with + potential immunomodulating and antineoplastic activities. Upon intradermal delivery + by electroporation of GNOS-PVO2, the patient-specific neoantigens are translated + in cells and elicit a specific and potent cytotoxic T-lymphocyte (CTL) response + against tumor cells expressing these neoantigens, resulting in tumor cell lysis. + Each patient specific formulation may contain multiple DNA plasmids, and each + plasmid may contain multiple neoantigen DNA sequences, allowing the delivery + of multiple neoantigen DNA sequences simultaneously. + termDef: + term: >- + Personalized Neoantigen DNA Vaccine GNOS-PVO2 + source: NCIt + cde_id: C170950 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170950" + term_id: C170950 + term_version: 20.10d + +peru: + common: + description: >- + A country in western South America, bordering the South Pacific Ocean, between + Chile and Ecuador. + termDef: + term: >- + Peru + source: NCIt + cde_id: C16972 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16972" + term_id: C16972 + term_version: 19.12e + +pgr: + common: + description: >- + This gene plays a role in the signal transduction processes that are involved + in pregnancy. + termDef: + term: >- + PGR Gene + source: NCIt + cde_id: C28656 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28656" + term_id: C28656 + term_version: 20.10d + +pharynx_nos: + common: + description: >- + A hollow tube that starts posterior to the mouth and nasal cavity and ends superior + to the trachea and esophagus. + termDef: + term: >- + Pharynx + source: NCIt + cde_id: C12425 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12425" + term_id: C12425 + term_version: 20.05a + +pheochromoblastoma: + common: + description: >- + A pheochromocytoma that metastasizes to other anatomic sites. Common sites + of metastasis include lymph nodes, bones, liver, and lung. Morphologic features + associated with malignant pheochromocytomas include: atypical mitotic figures, + capsular and vascular invasion, tumor cell necrosis, and high mitotic activity. + termDef: + term: >- + Malignant Adrenal Gland Pheochromocytoma + source: NCIt + cde_id: C4220 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4220" + term_id: C4220 + term_version: 20.05a + +pheochromocytoma_malignant: + common: + description: >- + A pheochromocytoma that metastasizes to other anatomic sites. Common sites + of metastasis include lymph nodes, bones, liver, and lung. Morphologic features + associated with malignant pheochromocytomas include: atypical mitotic figures, + capsular and vascular invasion, tumor cell necrosis, and high mitotic activity. + termDef: + term: >- + Malignant Adrenal Gland Pheochromocytoma + source: NCIt + cde_id: C4220 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4220" + term_id: C4220 + term_version: 20.05a + +pheochromocytoma_nos: + common: + description: >- + A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system + that secretes catecholamines. It arises from the chromaffin cells of the adrenal + medulla. Clinical presentation includes headaches, palpitations, chest and + abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic + nesting (zellballen) growth pattern is usually seen. Other growth patterns + including trabecular pattern may also be present. + termDef: + term: >- + Adrenal Gland Pheochromocytoma + source: NCIt + cde_id: C3326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3326" + term_id: C3326 + term_version: 20.05a + +phf6: + common: + description: >- + This gene plays a role in transcriptional regulation. + termDef: + term: >- + PHF6 Gene + source: NCIt + cde_id: C101449 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101449" + term_id: C101449 + term_version: 20.10d + +philippines: + common: + description: >- + A country in southeastern Asia, comprised of an archipelago between the Philippine + Sea and the South China Sea, east of Vietnam. + termDef: + term: >- + Philippines + source: NCIt + cde_id: C16978 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16978" + term_id: C16978 + term_version: 19.12e + +phosphaturic_mesenchymal_tumor_malignant: + common: + description: >- + A phosphaturic mesenchymal tumor that has metastasized from its original site + of growth to other anatomic sites. + termDef: + term: >- + Malignant Phosphaturic Mesenchymal Tumor + source: NCIt + cde_id: C121789 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121789" + term_id: C121789 + term_version: 20.05a + +photodynamic_compound_tld1433: + common: + description: >- + A non-toxic ruthenium-based coordination-complex and photosensitizer, with potential + antineoplastic activity upon photodynamic therapy (PDT). Upon intravesical administration, + light-activated photodynamic compound (PDC) TLD-1433 targets and binds to transferrin + (Tf) and is subsequently taken up by Tf receptors which are located on tumor + cells. Upon exposure to green light (525nm), TLD-1433 becomes activated locally + and induces the generation of reactive oxygen species (ROS) and singlet oxygen. + The release of free radicals may induce apoptosis and destroy the tumor cells. + Cancer cells have many more Tf receptors than normal cells + termDef: + term: >- + Photodynamic Compound TLD-1433 + source: NCIt + cde_id: C172822 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172822" + term_id: C172822 + term_version: 20.10d + +phox2b: + common: + description: >- + This gene plays a role in the regulation of transcription. + termDef: + term: >- + PHOX2B Gene + source: NCIt + cde_id: C97724 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97724" + term_id: C97724 + term_version: 20.10d + +phyllodes_tumor_benign: + common: + description: >- + A benign, circumscribed fibroepithelial neoplasm arising from the breast and + rarely the prostate gland. It is characterized by the presence of epithelial + structures which are arranged in clefts and by a hypercellular mesenchymal stroma + which is organized in leaf-like structures. There is no evidence of cellular + atypia or sarcomatous features. + termDef: + term: >- + Benign Phyllodes Tumor + source: NCIt + cde_id: C4274 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4274" + term_id: C4274 + term_version: 20.05a + +phyllodes_tumor_borderline: + common: + description: >- + A phyllodes tumor with morphologic characteristics which are intermediate between + a benign and a malignant phyllodes tumor. The stromal sarcomatous changes are + of low grade and are often reminiscent of low grade fibrosarcomas. + termDef: + term: >- + Borderline Phyllodes Tumor + source: NCIt + cde_id: C7503 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7503" + term_id: C7503 + term_version: 20.05a + +phyllodes_tumor_malignant: + common: + description: >- + A phyllodes tumor with sarcomatous stroma. The sarcomatous component is usually + of the fibrosarcomatous type. Liposarcomatous, chondrosarcomatous, osteosarcomatous, + or rhabdomyosarcomatous differentiation may also occur in the stroma. It may + recur and metastasize following surgical resection. The lung and skeleton are + the anatomic sites most frequently involved by metastases. + termDef: + term: >- + Malignant Phyllodes Tumor + source: NCIt + cde_id: C4275 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4275" + term_id: C4275 + term_version: 20.05a + +phyllodes_tumor_nos: + common: + description: >- + A benign, borderline, or malignant fibroepithelial neoplasm arising from the + breast and rarely the prostate gland. It may recur following resection. The + recurrence rates are higher for borderline and malignant phyllodes tumors. In + borderline and malignant phyllodes tumors metastases to distant anatomic sites + can occur. The incidence of metastases is higher in malignant phyllodes tumors. + termDef: + term: >- + Phyllodes Tumor + source: NCIt + cde_id: C2977 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2977" + term_id: C2977 + term_version: 20.05a + +physical_exam: + common: + description: >- + A systemic evaluation of the body and its functions using visual inspection, + palpation, percussion and auscultation. The purpose is to determine the presence + or absence of physical signs of disease or abnormality for an individual's health + assessment. + termDef: + term: >- + Physical Examination + source: NCIt + cde_id: C20989 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20989" + term_id: C20989 + term_version: 20.05a + +picalm: + common: + description: >- + This gene plays a role in receptor mediated endocytosis. + termDef: + term: >- + PICALM Gene + source: NCIt + cde_id: C84434 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84434" + term_id: C84434 + term_version: 20.10d + +pick_tubular_adenoma: + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +pigmented_adenoma: + common: + description: >- + A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark + brown appearance and is characterized by the presence of neoplastic cells containing + abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome. + termDef: + term: >- + Pigmented Adrenal Cortex Adenoma + source: NCIt + cde_id: C4164 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4164" + term_id: C4164 + term_version: 20.05a + +pigmented_basal_cell_carcinoma: + common: + description: >- + A basal cell carcinoma that contains large amounts of melanin. The melanin + is produced by symbiotic nontumoral proliferating melanocytes. + termDef: + term: >- + Skin Pigmented Basal Cell Carcinoma + source: NCIt + cde_id: C9359 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9359" + term_id: C9359 + term_version: 20.05a + +pigmented_dermatofibrosarcoma_protuberans: + common: + description: >- + A morphologic variant of dermatofibrosarcoma protuberans characterized by the + presence of melanin-pigmented dendritic cells. + termDef: + term: >- + Pigmented Dermatofibrosarcoma Protuberans + source: NCIt + cde_id: C9430 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9430" + term_id: C9430 + term_version: 20.05a + +pigmented_nevus_nos: + common: + description: >- + A nevus characterised by the presence of excessive pigment. + termDef: + term: >- + Pigmented Nevus + source: NCIt + cde_id: C27816 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27816" + term_id: C27816 + term_version: 20.05a + +pigmented_schwannoma: + common: + description: >- + A rare circumscribed, non-encapsulated and grossly pigmented nerve sheath tumor. + It is composed of cells with the immunophenotypic and electron microscopic features + of Schwann cells which contain melanosomes and are positive for melanoma markers. + It usually involves spinal nerve roots but may occur in other locations. It + may be associated with PRKAR1A gene mutation and Carney complex. Malignant behavior + has been reported in a significant number of patients. + termDef: + term: >- + Melanotic Schwannoma + source: NCIt + cde_id: C6970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6970" + term_id: C6970 + term_version: 20.05a + +pigmented_spindle_cell_nevus_of_reed: + common: + description: >- + A benign, small and slightly elevated brown or black skin lesion with usually + well-demarcated borders. It is characterized by the presence of a melanocytic + proliferation resulting in the formation of uniform cellular nests. Sometimes + the clinical and morphologic features may be difficult to distinguish from melanoma. + termDef: + term: >- + Pigmented Spindle Cell Nevus + source: NCIt + cde_id: C4751 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4751" + term_id: C4751 + term_version: 20.05a + +pik3ca: + common: + description: >- + This gene is involved in apoptosis, cell growth and angiogenesis. + termDef: + term: >- + PIK3CA Gene + source: NCIt + cde_id: C21220 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21220" + term_id: C21220 + term_version: 20.10d + +pik3cb: + common: + description: >- + This gene is involved in apoptosis, cell growth and angiogenesis. + termDef: + term: >- + PIK3CB Gene + source: NCIt + cde_id: C24672 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24672" + term_id: C24672 + term_version: 20.10d + +pik3r1: + common: + description: >- + This gene is involved in phosphoinositol signaling. + termDef: + term: >- + PIK3R1 Gene + source: NCIt + cde_id: C97733 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97733" + term_id: C97733 + term_version: 20.10d + +pilar_tumor: + common: + description: >- + A neoplasm with tricholemmal differentiation. It affects women more frequently + than men. It usually presents on the scalp as a solitary, multilobular, large, + exophytic mass. Morphologically, it may display benign cytological features + and appear as a circumscribed solid-cystic neoplasm or it may display malignant + characteristics and invasive features. Cases without malignant characteristics + usually have an indolent course. Complete surgical excision is recommended in + such cases to avoid recurrences and to allow complete examination of the specimen. + Cases with malignant characteristics may have a locally aggressive clinical + course, recur, or metastasize. + termDef: + term: >- + Proliferating Trichilemmal Tumor + source: NCIt + cde_id: C27125 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27125" + term_id: C27125 + term_version: 20.05a + +pilocytic_astrocytoma: + common: + description: >- + A WHO grade I, relatively circumscribed, slowly growing, often cystic astrocytoma + occurring in children and young adults. Histologically it is characterized + by a biphasic pattern with compacted bipolar cells associated with Rosenthal + fibers and multipolar cells associated with microcysts and eosinophilic bodies/hyaline + droplets. (WHO) + termDef: + term: >- + Pilocytic Astrocytoma + source: NCIt + cde_id: C4047 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4047" + term_id: C4047 + term_version: 20.05a + +piloid_astrocytoma: + common: + description: >- + A WHO grade I, relatively circumscribed, slowly growing, often cystic astrocytoma + occurring in children and young adults. Histologically it is characterized + by a biphasic pattern with compacted bipolar cells associated with Rosenthal + fibers and multipolar cells associated with microcysts and eosinophilic bodies/hyaline + droplets. (WHO) + termDef: + term: >- + Pilocytic Astrocytoma + source: NCIt + cde_id: C4047 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4047" + term_id: C4047 + term_version: 20.05a + +pilomatricoma_malignant: + common: + description: >- + A very rare, locally aggressive, malignant neoplasm of the hair follicle. The + majority of the cases arise de novo, however malignant transformation from a + pre-existing pilomatricoma has been reported. It usually presents as a solitary + nodule in the head and neck, upper extremities, or buttocks. Morphologically, + it is characterized by the presence of aggregates of basaloid cells infiltrating + the dermis. Masses of ghost cells are present in the cellular aggregates. Complete + surgical excision is the treatment of choice. If it is not completely removed, + it usually recurs, but it rarely metastasizes to distant anatomic sites. + termDef: + term: >- + Pilomatrical Carcinoma + source: NCIt + cde_id: C4114 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4114" + term_id: C4114 + term_version: 20.05a + +pilomatricoma_nos: + common: + description: >- + A benign adnexal neoplasm arising from hair-bearing skin surfaces, usually the + head and neck and upper extremities. It usually presents as a solitary, slow-growing + nodular mass. Morphologically, it displays differentiation towards the matrix + and inner sheath of the normal hair follicle and the hair cortex. Complete surgical + excision is usually curative. Occasionally, it may recur. + termDef: + term: >- + Pilomatricoma + source: NCIt + cde_id: C7368 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7368" + term_id: C7368 + term_version: 20.05a + +pilomatrix_carcinoma: + common: + description: >- + A very rare, locally aggressive, malignant neoplasm of the hair follicle. The + majority of the cases arise de novo, however malignant transformation from a + pre-existing pilomatricoma has been reported. It usually presents as a solitary + nodule in the head and neck, upper extremities, or buttocks. Morphologically, + it is characterized by the presence of aggregates of basaloid cells infiltrating + the dermis. Masses of ghost cells are present in the cellular aggregates. Complete + surgical excision is the treatment of choice. If it is not completely removed, + it usually recurs, but it rarely metastasizes to distant anatomic sites. + termDef: + term: >- + Pilomatrical Carcinoma + source: NCIt + cde_id: C4114 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4114" + term_id: C4114 + term_version: 20.05a + +pilomatrixoma_malignant: + common: + description: >- + A very rare, locally aggressive, malignant neoplasm of the hair follicle. The + majority of the cases arise de novo, however malignant transformation from a + pre-existing pilomatricoma has been reported. It usually presents as a solitary + nodule in the head and neck, upper extremities, or buttocks. Morphologically, + it is characterized by the presence of aggregates of basaloid cells infiltrating + the dermis. Masses of ghost cells are present in the cellular aggregates. Complete + surgical excision is the treatment of choice. If it is not completely removed, + it usually recurs, but it rarely metastasizes to distant anatomic sites. + termDef: + term: >- + Pilomatrical Carcinoma + source: NCIt + cde_id: C4114 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4114" + term_id: C4114 + term_version: 20.05a + +pilomatrixoma_nos: + common: + description: >- + A benign adnexal neoplasm arising from hair-bearing skin surfaces, usually the + head and neck and upper extremities. It usually presents as a solitary, slow-growing + nodular mass. Morphologically, it displays differentiation towards the matrix + and inner sheath of the normal hair follicle and the hair cortex. Complete surgical + excision is usually curative. Occasionally, it may recur. + termDef: + term: >- + Pilomatricoma + source: NCIt + cde_id: C7368 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7368" + term_id: C7368 + term_version: 20.05a + +pilomyxoid_astrocytoma: + common: + description: >- + An astrocytic tumor of uncertain relation to pilocytic astrocytoma. It occurs + predominantly in infants and young children. It is characterized by a monomorphic + architectural pattern, usually associated with the absence of Rosenthal fibers + and eosinophilic granular bodies. The clinical course is usually aggressive. + termDef: + term: >- + Pilomyxoid Astrocytoma + source: NCIt + cde_id: C40315 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40315" + term_id: C40315 + term_version: 20.05a + +pim1: + common: + description: >- + This gene is involved in apoptosis, cell cycle regulation and signal transduction. + termDef: + term: >- + PIM1 Gene + source: NCIt + cde_id: C18337 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18337" + term_id: C18337 + term_version: 20.10d + +pimitespib: + common: + description: >- + A specific inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, + with potential antineoplastic and chemo/radiosensitizing activities. Upon oral + administration, pimitespib specifically binds to and inhibits the activity of + Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic + client proteins, which inhibits client protein dependent-signaling, induces + apoptosis, and inhibits the proliferation of cells overexpressing HSP90alpha/beta. + Hsp90, a family of molecular chaperone proteins that are upregulated in a variety + of tumor cells, plays a key role in the conformational maturation, stability, + and function of "client" proteins within the cell,; many of which are involved + in signal transduction, cell cycle regulation and apoptosis, including kinases, + cell-cycle regulators, transcription factors and hormone receptors. As TAS-116 + selectively inhibits cytosolic HSP90alpha and beta only and does not inhibit + HSP90 paralogs, such as endoplasmic reticulum GRP94 or mitochondrial TRAP1, + this agent may have less off-target toxicity as compared to non-selective HSP90 + inhibitors. + termDef: + term: >- + Pimitespib + source: NCIt + cde_id: C134448 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C134448" + term_id: C134448 + term_version: 20.10d + +pimurutamab: + common: + description: >- + A glycoengineered humanized version of the monoclonal antibody of cetuximab, + with potential antineoplastic activity. Upon intravenous administration, pimurutamab + selectively targets and binds to the extracellular domain of the epidermal growth + factor receptor (EGFR), thereby preventing the activation and subsequent dimerization + of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent + tumor cell proliferation. In addition, the glyco-optimization promotes antibody-dependent + cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor + family of extracellular protein ligands, may be overexpressed on the cell surfaces + of certain tumor types. + termDef: + term: >- + Pimurutamab + source: NCIt + cde_id: C163981 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C163981" + term_id: C163981 + term_version: 20.10d + +pin_iii: + common: + description: >- + High grade prostatic intraepithelial neoplasia characterized by the presence + of severe architectural and cytologic abnormalities. + termDef: + term: >- + Grade III Prostatic Intraepithelial Neoplasia + source: NCIt + cde_id: C3642 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3642" + term_id: C3642 + term_version: 20.05a + +pinatuzumab_vedotin: + common: + description: >- + An antibody-drug conjugate (ADC) composed of MCDT2219A, a humanized IgG1 anti-CD22 + monoclonal antibody covalently linked, via a protease-cleavable peptide linker, + to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule + disrupting agent, with potential antineoplastic activity. Upon administration, + the monoclonal antibody moiety of pinatuzumab vedotin binds to B cell-specific + CD22 receptors and is rapidly internalized, thereby delivering MMAE intracellularly. + Upon proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, + resulting in G2/M phase arrest and tumor cell apoptosis. CD22, a cell surface + glycoprotein, is expressed on mature B-cells and on most malignant B-cells. + termDef: + term: >- + Pinatuzumab Vedotin + source: NCIt + cde_id: C104167 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104167" + term_id: C104167 + term_version: 20.10d + +pindborg_tumor: + common: + description: >- + A slow growing, locally invasive neoplasm arising from tooth-forming tissues. + It most often grows intraosseously in the mandible and less frequently in the + maxilla. In a minority of cases it grows extraosseously in the gingiva. It is + characterized by the presence of a fibrous stroma, epithelial cells with abundant + eosinophilic cytoplasm, and amyloid material which is often calcified. Small + tumors may be successfully treated with enucleation. Local resection is usually + required for larger tumors. Recurrences have been reported in a minority of + cases. + termDef: + term: >- + Calcifying Epithelial Odontogenic Tumor + source: NCIt + cde_id: C54301 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54301" + term_id: C54301 + term_version: 20.05a + +pineal_gland: + common: + description: >- + A small endocrine gland in the brain, situated beneath the back part of the + corpus callosum, that secretes melatonin. + termDef: + term: >- + Pineal Gland + source: NCIt + cde_id: C12398 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12398" + term_id: C12398 + term_version: 20.05a + +pineal_parenchymal_tumor_of_intermediate_differentiation: + common: + description: >- + A WHO grade II or III pineal parenchymal neoplasm of intermediate-grade malignancy, + affecting all ages. It is composed of diffuse sheets or large lobules of uniform + cells with mild to moderate nuclear atypia and low to moderate level mitotic + activity. (Adapted from WHO) + termDef: + term: >- + Pineal Parenchymal Tumor of Intermediate Differentiation + source: NCIt + cde_id: C6967 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6967" + term_id: C6967 + term_version: 20.05a + +pinealoma: + common: + description: >- + A benign or malignant neoplasm that affects the pineal region. + termDef: + term: >- + Pineal Region Neoplasm + source: NCIt + cde_id: C3328 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3328" + term_id: C3328 + term_version: 20.05a + +pineoblastoma: + common: + description: >- + A poorly differentiated malignant embryonal neoplasm arising from the pineal + region. It usually occurs in children and it is characterized by the presence + of small immature neuroepithelial cells. It may follow an aggressive clinical + course. + termDef: + term: >- + Pineoblastoma + source: NCIt + cde_id: C9344 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9344" + term_id: C9344 + term_version: 20.05a + +pineocytoma: + common: + description: >- + A WHO grade I slow growing tumor, more frequently affecting young adults. It + is composed of small, uniform, mature cells resembling pineocytes with occasional + large pineocytomatous rosettes. It may show a wide range of divergent phenotypes, + including neuronal, glial, melanocytic, photoreceptor and mesenchymal differentiation. + Pineocytoma generally has a relatively favorable prognosis. (Adapted from WHO) + termDef: + term: >- + Pineocytoma + source: NCIt + cde_id: C6966 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6966" + term_id: C6966 + term_version: 20.05a + +pinkus_tumor: + common: + description: >- + A variant of basal cell carcinoma presenting as an elevated or erythematous + nodular lesion usually in the back. Morphologically, it is characterized by + the presence of cords of basaloid cells extending from the epidermis into the + dermis, creating a fenestrating pattern. It follows an indolent course. + termDef: + term: >- + Skin Fibroepithelial Basal Cell Carcinoma + source: NCIt + cde_id: C4109 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4109" + term_id: C4109 + term_version: 20.05a + +pipe: + common: + description: >- + A tube with a small bowl at one end, especially one used for smoking tobacco. + termDef: + term: >- + Pipe + source: NCIt + cde_id: C86044 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C86044" + term_id: C86044 + term_version: 19.12e + +pituicytoma: + common: + description: >- + An extremely rare, WHO grade I, circumscribed and slow-growing tumor that arises + from the neurohypophysis or infundibulum and described in adults. It is characterized + by the presence of elongated, spindle-shaped neoplastic glial cells that form + storiform patterns or interlacing fascicular arrangements. Signs and symptoms + include visual disturbances, headache, amenorrhea, and decreased libido. + termDef: + term: >- + Pituicytoma + source: NCIt + cde_id: C94524 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94524" + term_id: C94524 + term_version: 20.05a + +pituitary_adenoma_nos: + common: + description: >- + A non-metastasizing tumor that arises from the adenohypophysial cells of the + anterior lobe of the pituitary gland. The tumor can be hormonally functioning + or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. + Due to its location in the sella turcica, expansion of the tumor mass can impinge + on the optic chiasm or involve the temporal lobe, third ventricle and posterior + fossa A frequently associated physical finding is bitemporal hemianopsia which + may progress to further visual loss. + termDef: + term: >- + Pituitary Gland Adenoma + source: NCIt + cde_id: C3329 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3329" + term_id: C3329 + term_version: 20.05a + +pituitary_carcinoma_nos: + common: + description: >- + A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial + cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The + majority are hormonally functioning neoplasms, usually producing prolactin or + ACTH. The diagnosis is based on the presence of metastases. Syndromes associated + with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, + and acromegaly. + termDef: + term: >- + Pituitary Gland Carcinoma + source: NCIt + cde_id: C4536 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4536" + term_id: C4536 + term_version: 20.05a + +pituitary_gland: + common: + description: >- + Pea-sized endocrine gland located at the base of the brain in the pituitary + fossa. It produces and secretes hormones such as oxytocin and vasopressin, to + regulate the activities of the hypothalamus. + termDef: + term: >- + Pituitary Gland + source: NCIt + cde_id: C12399 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12399" + term_id: C12399 + term_version: 20.05a + +pixatimod: + common: + description: >- + A synthetic heparan sulfate mimetic with potential anti-angiogenic and antineoplastic + activity. Pixatimod inhibits the cleavage of heparan sulfate from cell surface + proteoglycan by heparanase and thus inhibits the neovascularization induced + by interaction between heparan sulfate and other extracellular matrix proteins. + In this manner, this agent may have the potential to slow the progression of + growth of solid tumors. + termDef: + term: >- + Pixatimod + source: NCIt + cde_id: C95202 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95202" + term_id: C95202 + term_version: 20.10d + +placenta: + common: + description: >- + An organ present in some vertebrates during embryonic gestation that surrounds + the fetus and provides it with nutrients and oxygen, facilitates gas and waste + exchange between the fetus and mother, and provides parasitic cloaking from + the mother's immune system by excretion of neurokinin B. + termDef: + term: >- + Placenta + source: NCIt + cde_id: C13272 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13272" + term_id: C13272 + term_version: 20.05a + +placental_site_trophoblastic_tumor: + common: + description: >- + A rare gestational trophoblastic tumor characterized by the presence of a diffuse + cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts + and by the absense of a significant population of syncytiotrophoblasts. + termDef: + term: >- + Placental-Site Gestational Trophoblastic Tumor + source: NCIt + cde_id: C3757 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3757" + term_id: C3757 + term_version: 20.05a + +plag1: + common: + description: >- + This gene is involved in cellular proliferation. + termDef: + term: >- + PLAG1 Gene + source: NCIt + cde_id: C71423 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71423" + term_id: C71423 + term_version: 20.10d + +plamotamab: + common: + description: >- + A bispecific, Fc domain-containing, monoclonal antibody with potential antineoplastic + activity. Plamotamab contains two antigen-recognition sites: one for human CD3, + a T cell surface antigen, and one for human CD20, a tumor-associated antigen + (TAA) that is exclusively expressed on B-cells during most stages of B-cell + development and is often overexpressed in B-cell malignancies. Upon administration, + plamotamab binds to both T-cells and CD20-expressing B-lineage tumor cells. + The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) + response against the CD20-expressing tumor B-cells. Inclusion of an Fc domain + on the antibody prolongs the half-life of the bispecific antibody and enhances + T-cell-mediated tumor cell killing because the agent is able to bind to Fc receptors. + termDef: + term: >- + Plamotamab + source: NCIt + cde_id: C130050 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C130050" + term_id: C130050 + term_version: 20.10d + +plasma: + common: + description: >- + Plasma is the fluid (noncellular) portion of the circulating blood, as distinguished + from the serum that is the fluid portion of the blood obtained by removal of + the fibrin clot and blood cells after coagulation. + termDef: + term: >- + Plasma + source: NCIt + cde_id: C13356 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13356" + term_id: C13356 + term_version: 20.10d + +plasma_cell_leukemia: + common: + description: >- + An aggressive plasma cell neoplasm characterized by the presence of neoplastic + plasma cells in the peripheral blood. It is characterized by the presence of + a circulating clonal plasma cell count that exceeds 2x10^9/L or is 20% of the + leukocyte differential count. + termDef: + term: >- + Plasma Cell Leukemia + source: NCIt + cde_id: C3180 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3180" + term_id: C3180 + term_version: 20.05a + +plasma_cell_myeloma: + common: + description: >- + A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal + protein and skeletal destruction with osteolytic lesions, pathological fractures, + bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory + myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, + 2001) + termDef: + term: >- + Plasma Cell Myeloma + source: NCIt + cde_id: C3242 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3242" + term_id: C3242 + term_version: 20.05a + +plasma_cell_tumor: + common: + description: >- + A clonal proliferation of immunoglobulin-secreting plasma cells. This category + includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal + immunoglobulin deposition disease, and monoclonal gammopathy of undetermined + significance. + termDef: + term: >- + Plasma Cell Neoplasm + source: NCIt + cde_id: C4665 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4665" + term_id: C4665 + term_version: 20.05a + +plasmablastic_lymphoma: + common: + description: >- + An aggressive diffuse large B-cell lymphoma frequently arising in the setting + of HIV infection and characterized by the presence of large neoplastic cells + resembling B-immunoblasts which have the immunophenotypic profile of plasma + cells. Sites of involvement include the oral cavity, sinonasal cavity, skin, + soft tissues, gastrointestinal tract, and bone. + termDef: + term: >- + Plasmablastic Lymphoma + source: NCIt + cde_id: C7224 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7224" + term_id: C7224 + term_version: 20.05a + +plasmacytic_leukemia: + common: + description: >- + An aggressive plasma cell neoplasm characterized by the presence of neoplastic + plasma cells in the peripheral blood. It is characterized by the presence of + a circulating clonal plasma cell count that exceeds 2x10^9/L or is 20% of the + leukocyte differential count. + termDef: + term: >- + Plasma Cell Leukemia + source: NCIt + cde_id: C3180 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3180" + term_id: C3180 + term_version: 20.05a + +plasmacytic_lymphoma: + common: + description: >- + A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma + cells involving the bone marrow, lymph nodes, and the spleen. The majority of + patients have a serum IgM paraprotein. + termDef: + term: >- + Lymphoplasmacytic Lymphoma + source: NCIt + cde_id: C3212 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3212" + term_id: C3212 + term_version: 20.05a + +plasmacytoma_extramedullary: + common: + description: >- + A plasma cell neoplasm arising at an extraosseous site. There is no involvement + of the bone marrow. It most frequently involves the oropharynx, nasopharynx, + sinuses, and larynx. Other sites of involvement include the gastrointestinal + tract, central nervous system, breast, skin, lymph nodes, and bladder. A minority + of patients have a monoclonal gammopathy. Treatment includes radiation therapy. + Progression to plasma cell myeloma occurs in a minority of patients. + termDef: + term: >- + Extraosseous Plasmacytoma + source: NCIt + cde_id: C4002 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4002" + term_id: C4002 + term_version: 20.05a + +plasmacytoma_nos: + common: + description: >- + A malignant (clonal) proliferation of plasma cells that are cytologically and + immunophenotypically identical to those of plasma cell myeloma, but manifest + a localized osseous or extraosseous growth pattern. (WHO, 2001) + termDef: + term: >- + Plasmacytoma + source: NCIt + cde_id: C9349 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9349" + term_id: C9349 + term_version: 20.05a + +plasmacytoma_of_bone: + common: + description: >- + A localized, clonal (malignant) plasma cell infiltrate in the bone, without + peripheral blood involvement. The most commonly affected bones are the vertebrae, + ribs, skull, pelvis and femur. X-rays examination reveals a solitary lytic + lesion. + termDef: + term: >- + Solitary Osseous Plasmacytoma + source: NCIt + cde_id: C7812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7812" + term_id: C7812 + term_version: 20.05a + +plasmid_dna_vaccine_pinghher3fl: + common: + description: >- + A plasmid DNA cancer vaccine encoding the tumor-associated antigen (TAA) human + epidermal growth factor receptor type-3 (HER-3; HER3), with potential antineoplastic + and immunomodulating activities. Upon intramuscular administration of the plasmid + DNA vaccine pING-hHER3FL and after cellular uptake by muscle cells, the plasmid + DNA expresses HER-3 which, may elicit both antigen-specific cytotoxic T-lymphocyte + (CTL) and humoral immune responses against tumor cells expressing HER-3. HER-3 + plays a key role in tumor cell proliferation and its overexpression is associated + with poor prognosis. HER-3 is associated with tumor cell resistance to anti-HER-2 + therapeutics. + termDef: + term: >- + Plasmid DNA Vaccine pING-hHER3FL + source: NCIt + cde_id: C171387 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171387" + term_id: C171387 + term_version: 20.10d + +platelets: + common: + description: >- + The determination of the number of platelets in a biospecimen. + termDef: + term: >- + Platelet Count + source: NCIt + cde_id: C51951 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51951" + term_id: C51951 + term_version: 20.10d + +plcg1: + common: + description: >- + This gene is involved in both intracellular signaling and second messenger production. + termDef: + term: >- + PLCG1 Gene + source: NCIt + cde_id: C104821 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104821" + term_id: C104821 + term_version: 20.10d + +pleomorphic_adenoma: + common: + description: >- + A neoplasm characterized by the presence of benign epithelial and myoepithelial + cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, + or osseous areas. It may be completely or partially encapsulated. It occurs + in the parotid gland, submandibular gland, minor salivary glands in the oral + cavity, upper respiratory tract, and nasal cavity and paranasal sinuses. It + usually presents as a slow growing painless mass. Infrequently, patients may + present with pain and facial palsy. It may recur after excision or transform + to a malignant neoplasm (carcinoma ex pleomorphic adenoma). + termDef: + term: >- + Pleomorphic Adenoma + source: NCIt + cde_id: C8602 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8602" + term_id: C8602 + term_version: 20.05a + +pleomorphic_carcinoma: + common: + description: >- + A usually aggressive malignant epithelial neoplasm composed of cells with significant + cytologic atypia and nuclear pleomorphism. + termDef: + term: >- + Pleomorphic Carcinoma + source: NCIt + cde_id: C4094 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4094" + term_id: C4094 + term_version: 20.05a + +pleomorphic_cell_sarcoma: + common: + description: >- + A sarcoma characterized by the presence of large, anaplastic malignant cells. + termDef: + term: >- + Giant Cell Sarcoma + source: NCIt + cde_id: C66759 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66759" + term_id: C66759 + term_version: 20.05a + +pleomorphic_leiomyoma: + common: + description: >- + A morphologic variant of leiomyoma characterized by the presence of pleomorphic + muscle cells with bizarre hyperchromatic nuclei and eosinophilic cytoplasm. + termDef: + term: >- + Bizarre Leiomyoma + source: NCIt + cde_id: C4257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4257" + term_id: C4257 + term_version: 20.05a + +pleomorphic_lipoma: + common: + description: >- + A benign circumscribed tumor characterized by small spindle cells, rounded hyperchromatic + cells and multinucleated giant cells with radially arranged nuclei. + termDef: + term: >- + Pleomorphic Lipoma + source: NCIt + cde_id: C3703 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3703" + term_id: C3703 + term_version: 20.05a + +pleomorphic_liposarcoma: + common: + description: >- + A liposarcoma characterized by the presence of varying proportions of pleomorphic + lipoblasts in a background that resembles undifferentiated pleomorphic sarcoma. It + is the rarest liposarcoma variant and usually has an aggressive clinical course. + termDef: + term: >- + Pleomorphic Liposarcoma + source: NCIt + cde_id: C3705 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3705" + term_id: C3705 + term_version: 20.05a + +pleomorphic_lobular_carcinoma: + common: + description: >- + A grade II invasive lobular carcinoma of the breast, characterized by the presence + of neoplastic cells with large and atypical nuclei. + termDef: + term: >- + Invasive Lobular Breast Carcinoma, Pleomorphic Variant + source: NCIt + cde_id: C97051 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97051" + term_id: C97051 + term_version: 20.05a + +pleomorphic_lobular_carcinoma_in_situ: + common: + description: >- + A recently described aggressive subtype of classic lobular breast carcinoma + in situ. It is characterized by the presence of neoplastic large cells with + irregular nuclei and prominent single or multiple nucleoli. + termDef: + term: >- + Pleomorphic Lobular Breast Carcinoma In Situ + source: NCIt + cde_id: C137839 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137839" + term_id: C137839 + term_version: 20.05a + +pleomorphic_rhabdomyosarcoma_adult_type: + common: + description: >- + An aggressive rhabdomyosarcoma occurring in adults. The neoplasm is characterized + by the presence of bizarre round, spindle, and polygonal cells. Clinical presentation + includes a rapidly enlarging painful mass usually in the lower extremities. + termDef: + term: >- + Adult Pleomorphic Rhabdomyosarcoma + source: NCIt + cde_id: C27369 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27369" + term_id: C27369 + term_version: 20.05a + +pleomorphic_rhabdomyosarcoma_nos: + common: + description: >- + An aggressive malignant mesenchymal neoplasm with skeletal muscle differentiation, + occurring in adults and rarely in children. The tumor is characterized by the + presence of bizarre round, spindle, and polygonal cells. Clinical presentation + includes a rapidly enlarging painful mass usually of the lower extremities. + termDef: + term: >- + Pleomorphic Rhabdomyosarcoma + source: NCIt + cde_id: C4258 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4258" + term_id: C4258 + term_version: 20.05a + +pleomorphic_xanthoastrocytoma: + common: + description: >- + A WHO grade ll astrocytic tumor with a relatively favorable prognosis. It is + characterized by pleomorphic and lipidized cells expressing GFAP often surrounded + by a reticulin network and eosinophilic granular bodies. It presents in the + superficial cerebral hemispheres and involves the meninges. It typically affects + children and young adults. + termDef: + term: >- + Pleomorphic Xanthoastrocytoma + source: NCIt + cde_id: C4323 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4323" + term_id: C4323 + term_version: 20.05a + +pleura: + common: + description: >- + The tissue that lines the wall of the thoracic cavity and the surface of the + lungs. + termDef: + term: >- + Pleura + source: NCIt + cde_id: C12469 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12469" + term_id: C12469 + term_version: 20.05a + +pleura_nos: + common: + description: >- + The tissue that lines the wall of the thoracic cavity and the surface of the + lungs. + termDef: + term: >- + Pleura + source: NCIt + cde_id: C12469 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12469" + term_id: C12469 + term_version: 20.05a + +pleural_fluid: + common: + description: >- + The fluid that is ordinarily present in the pleural space. It allows for normal + movement of the lungs during respiration. + termDef: + term: >- + Pleural Fluid + source: NCIt + cde_id: C77613 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77613" + term_id: C77613 + term_version: 20.10d + +pleuropulmonary_blastoma: + common: + description: >- + A malignant neoplasm affecting the lungs and/or the pleura. Pleuropulmonary + blastoma is seen in children. Microscopically, the tumor may show features of + chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated + sarcoma. In approximately 25% of patients with pleuropulmonary blastoma, there + are other lesions or neoplasms that may affect patients or their families, including + lung or kidney cysts, and ovarian or testicular neoplasms. Heterozygous germline + mutations in DICER1 gene have been identified in families harboring pleuropulmonary + blastomas. + termDef: + term: >- + Pleuropulmonary Blastoma + source: NCIt + cde_id: C5669 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5669" + term_id: C5669 + term_version: 20.05a + +plexiform_fibrohistiocytic_tumor: + common: + description: >- + An intermediate fibrohistiocytic neoplasm of the skin that usually affects children + and young adults. It is a multinodular, poorly circumscribed tumor characterized + by the presence of multinucleated giant cells, mononuclear histiocyte-like cells, + and spindle fibroblast-like cells arranged in a plexiform pattern. + termDef: + term: >- + Plexiform Fibrohistiocytic Tumor + source: NCIt + cde_id: C6493 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6493" + term_id: C6493 + term_version: 20.05a + +plexiform_hemangioma: + common: + description: >- + A capillary hemangioma that may regress spontaneously. It occurs in infants + and children. + termDef: + term: >- + Infantile Hemangioma + source: NCIt + cde_id: C6645 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6645" + term_id: C6645 + term_version: 20.05a + +plexiform_neurofibroma: + common: + description: >- + An elongated and multinodular neurofibroma, formed when the tumor involves either + multiple trunks of a plexus or multiple fascicles of a large nerve, such as + the sciatic. Some plexiform neurofibromas resemble a bag of worms, others produce + a massive ropy enlargement of the nerve. (Adapted from WHO) + termDef: + term: >- + Plexiform Neurofibroma + source: NCIt + cde_id: C3797 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3797" + term_id: C3797 + term_version: 20.05a + +plexiform_neuroma: + common: + description: >- + An elongated and multinodular neurofibroma, formed when the tumor involves either + multiple trunks of a plexus or multiple fascicles of a large nerve, such as + the sciatic. Some plexiform neurofibromas resemble a bag of worms, others produce + a massive ropy enlargement of the nerve. (Adapted from WHO) + termDef: + term: >- + Plexiform Neurofibroma + source: NCIt + cde_id: C3797 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3797" + term_id: C3797 + term_version: 20.05a + +plexiform_schwannoma: + common: + description: >- + A schwannoma characterized by a plexiform or multinodular growth pattern. It + usually arises from the skin or subcutaneous tissues in the extremities, trunk, + and head and neck. + termDef: + term: >- + Plexiform Schwannoma + source: NCIt + cde_id: C6969 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6969" + term_id: C6969 + term_version: 20.05a + +pml: + common: + description: >- + This gene plays a role in tumor suppression and is involved in the regulation + of p53 in response to oncogenic signal transduction. + termDef: + term: >- + PML Gene + source: NCIt + cde_id: C24686 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24686" + term_id: C24686 + term_version: 20.10d + +pms1: + common: + description: >- + This gene is involved in mismatch repair and mutations in the gene result in + hereditary non-polyposis colon cancer 3. + termDef: + term: >- + PMS1 Gene + source: NCIt + cde_id: C18590 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18590" + term_id: C18590 + term_version: 20.10d + +pms2: + common: + description: >- + This gene is involved in mismatch repair and mutations in the gene result in + hereditary non-polyposis colon cancer 4. + termDef: + term: >- + PMS2 Gene + source: NCIt + cde_id: C18591 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18591" + term_id: C18591 + term_version: 20.10d + +pnet_nos: + common: + description: >- + A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm + constitutes the portion of the ectoderm of the early embryo that gives rise + to the central and peripheral nervous systems and includes some glial cell precursors. + termDef: + term: >- + Primitive Neuroectodermal Tumor + source: NCIt + cde_id: C3716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3716" + term_id: C3716 + term_version: 20.05a + +pneumoblastoma: + common: + description: >- + A biphasic tumor that consists of fetal adenocarcinoma (typically low-grade) + and primitive mesenchymal stroma. Foci of specific mesenchymal differentiation + (osteosarcoma, chondrosarcoma, or rhabdomyosarcoma) may also be present, but + are not required for the diagnosis. Most patients are smokers. The prognosis + is very poor. (WHO 2015) + termDef: + term: >- + Pulmonary Blastoma + source: NCIt + cde_id: C3732 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3732" + term_id: C3732 + term_version: 20.05a + +pngvl4acrte6e7l2_dna_vaccine: + common: + description: >- + A therapeutic DNA vaccine encoding human calreticulin (CRT) linked to human + papillomavirus (HPV) type 16 E6, E7, and L2 proteins, with potential immunomodulating + and antineoplastic activities. Upon administration via intramuscular injection + with electroporation, the pNGVL4a-CRT-E6E7L2 DNA vaccine expresses HPV16 E6, + E7 and L2 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response + and humoral immune responses against tumor cells expressing these proteins, + resulting in tumor cell lysis and tumor cell death. In addition, HPV16 L2-specific + neutralizing antibody may prevent a broad spectrum of HPV infections and HPV-associated + cancers. The heat shock protein CRT may potentiate MHC class I presentation + to antigen-specific CD8-positive T-cells, enhancing the induction of cellular + immunity and the potency of the vaccine. + termDef: + term: >- + pNGVL4a-CRT-E6E7L2 DNA Vaccine + source: NCIt + cde_id: C175536 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175536" + term_id: C175536 + term_version: 20.10d + +pngvl4asige7detoxhsp70_dna_and_hpv16_l2e6e7_fusion_protein_tacin_vaccine_pvx2: + common: + description: >- + A cancer vaccine consisting of a combination of two vaccines, a prime pNGVL4a-Sig/E7(detox)/HSP70 + DNA vaccine and a boost HPV16 L2/E6/E7 fusion protein TA-CIN vaccine, with potential + immunostimulating and antineoplastic activities. pNGVL4a-Sig/E7(detox)/HSP70 + DNA vaccine is an antigen-specific DNA cancer vaccine consisting of the coding + sequences of a signal peptide (pNGVL4a-Sig), a detox form of the human papillomavirus + type 16 (HPV-16) antigen E7, and the heat shock protein 70 (HSP70). Upon administration, + this prime vaccine may generate potent cytotoxic CD8(+) T-cell responses against + E7-expressing tumor cells, resulting in tumor cell death. HPV16 L2/E6/E7 fusion + protein TA-CIN vaccine is a recombinant human papillomavirus (HPV), genetically + engineered fusion protein vaccine in which the three HPV16 viral proteins L2, + E6 and E7 are fused together in a single tandem fusion protein (TA-CIN; HPV16 + L2\E6\E7). Upon administration, this boost vaccine may stimulate the immune + system to generate HPV16 E6\E7-specific CD4+ and CD8+ T-cell responses as well + as the induction of L2-specific antibodies. In addition, this vaccine may prevent + infection and the development of other HPV16-associated diseases. L2, a minor + viral capsid protein, is able to induce a strong antibody response against certain + HPV types. + termDef: + term: >- + pNGVL4a-Sig/E7(detox)/HSP70 DNA and HPV16 L2/E6/E7 Fusion Protein TA-CIN Vaccine + PVX-2 + source: NCIt + cde_id: C172205 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172205" + term_id: C172205 + term_version: 20.10d + +poland: + common: + description: >- + A country in central Europe, east of Germany. + termDef: + term: >- + Poland + source: NCIt + cde_id: C17002 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17002" + term_id: C17002 + term_version: 19.12e + +polar_spongioblastoma: + common: + description: >- + A lesion characterized by the presence of neoplastic neuroepithelial cells with + palisading nuclei. This lesion implies a morphologic growth pattern and it is + not considered a clinicopathological entity. + termDef: + term: >- + Polar Spongioblastoma + source: NCIt + cde_id: C66801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66801" + term_id: C66801 + term_version: 20.05a + +pold1: + common: + description: >- + This gene is involved in DNA replication and proofreading. + termDef: + term: >- + POLD1 Gene + source: NCIt + cde_id: C106224 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106224" + term_id: C106224 + term_version: 20.10d + +pole: + common: + description: >- + This gene is involved in both DNA replication and DNA base-excision repair. + termDef: + term: >- + POLE Gene + source: NCIt + cde_id: C106232 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106232" + term_id: C106232 + term_version: 20.10d + +polg: + common: + description: >- + This gene plays a role in the replication of mitochondrial DNA. + termDef: + term: >- + POLG Gene + source: NCIt + cde_id: C143069 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143069" + term_id: C143069 + term_version: 20.10d + +polq: + common: + description: >- + This gene is involved in DNA synthesis and repair. + termDef: + term: >- + POLQ Gene + source: NCIt + cde_id: C131801 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131801" + term_id: C131801 + term_version: 20.10d + +polycythemia_rubra_vera: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by an increased red blood + cell production. The bone marrow is hypercellular due to a panmyelotic proliferation + typically characterized by pleomorphic megakaryocytes. The major symptoms are + related to hypertension, splenomegaly or to episodes of thrombosis and/or hemorrhage. + termDef: + term: >- + Polycythemia Vera + source: NCIt + cde_id: C3336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3336" + term_id: C3336 + term_version: 20.05a + +polycythemia_vera: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by an increased red blood + cell production. The bone marrow is hypercellular due to a panmyelotic proliferation + typically characterized by pleomorphic megakaryocytes. The major symptoms are + related to hypertension, splenomegaly or to episodes of thrombosis and/or hemorrhage. + termDef: + term: >- + Polycythemia Vera + source: NCIt + cde_id: C3336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3336" + term_id: C3336 + term_version: 20.05a + +polygonal_cell_carcinoma: + common: + description: >- + A malignant epithelial neoplasm composed of atypical polygonal cells with a + large amount of eosinophilic cytoplasm. A representative example is the fibrolamellar + hepatocellular carcinoma. + termDef: + term: >- + Polygonal Cell Carcinoma + source: NCIt + cde_id: C65161 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65161" + term_id: C65161 + term_version: 20.05a + +polymerconjugated_il15_receptor_agonist_nktr255: + common: + description: >- + A long-acting formulation composed of the human cytokine interleukin-15 (IL-15) + that is conjugated by polymers, with potential immunomodulating and anti-tumor + activities. Upon administration of polymer-conjugated IL-15 receptor agonist + NKTR-255, the IL-15 moiety targets and binds to the alpha subunit of the IL-15 + receptor on natural killer (NK) and T-cells, thereby activating the IL-15-mediated + pathway. This leads to the expansion and activation of natural killer (NK) cells + and memory CD8+ T-cells, thereby enhancing the anti-tumor activity of NKs and + long-term memory T-lymphocyte immune responses. This may increase tumor cell + killing and decrease tumor cell proliferation. In addition, NKTR-255 may, when + combined with a tumor-directed antibody, enhance the antibody-dependent cell-mediated + cytotoxicity (ADCC) mechanism. IL-15 is a pro-inflammatory cytokine that plays + a key role in the regulation of T- and NK cell activation, proliferation and + promotion of their anti-tumor effects. Compared to IL-15 alone, the polymer + formulation allows for increased retention at the tumor site and reduced clearance, + thereby increasing the effect of IL-15. + termDef: + term: >- + Polymer-conjugated IL-15 Receptor Agonist NKTR-255 + source: NCIt + cde_id: C165666 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165666" + term_id: C165666 + term_version: 20.10d + +polymorphic_post_transplant_lymphoproliferative_disorder: + common: + description: >- + A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant + immunosuppression therapy. It is characterized by destructive infiltration of + lymph nodes and extranodal sites by a polymorphic B-cell infiltrate composed + of small and medium sized lymphocytes, immunoblasts, and plasma cells. In some + cases, reduction of the immunosuppression therapy may lead to regression of + the lesions. In other cases the lesions may progress to lymphoma. + termDef: + term: >- + Polymorphic Post-Transplant Lymphoproliferative Disorder + source: NCIt + cde_id: C7183 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7183" + term_id: C7183 + term_version: 20.05a + +polypoid_adenoma: + common: + description: >- + A polypoid neoplasm arising from the glandular epithelium. There is proliferation + of glandular cells which may display dysplastic cytologic features. Representative + examples include the adenomatous polyps of the colon and rectum. + termDef: + term: >- + Adenomatous Polyp + source: NCIt + cde_id: C3764 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3764" + term_id: C3764 + term_version: 20.05a + +polyvesicular_vitelline_tumor: + common: + description: >- + A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It + is the most common malignant germ cell tumor in the pediatric population. It + occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, + abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor + mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment + includes: surgical resection, radiation, and chemotherapy. This tumor is very + responsive to chemotherapy regimens that include cisplatinum. + termDef: + term: >- + Yolk Sac Tumor + source: NCIt + cde_id: C3011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3011" + term_id: C3011 + term_version: 20.05a + +poorly_cohesive_carcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of a diffuse cellular infiltrate + which is composed of poorly cohesive cells with minimal or no glandular formations. + Representative example is the gastric diffuse adenocarcinoma. + termDef: + term: >- + Diffuse Type Adenocarcinoma + source: NCIt + cde_id: C4127 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4127" + term_id: C4127 + term_version: 20.05a + +poorly_differentiated_neuroblastoma: + common: + description: >- + A neuroblastoma in which the differentiating neuroblasts constitute less than + five-percent of the tumor cells. + termDef: + term: >- + Poorly Differentiated Neuroblastoma + source: NCIt + cde_id: C42047 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C42047" + term_id: C42047 + term_version: 20.05a + +popliteal: + common: + description: >- + Lymph node located within the fat layer of the knee joint. + termDef: + term: >- + Popliteal Lymph Node + source: NCIt + cde_id: C53146 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53146" + term_id: C53146 + term_version: 20.10d + +porcupine_inhibitor_xnw7201: + common: + description: >- + An orally available inhibitor of porcupine (PORCN), with potential antineoplastic + activity. Upon oral administration, PORCN inhibitor XNW7201 targets, binds to + and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational + acylation of Wnt ligands and inhibits their secretion. This prevents the activation + of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth + in Wnt-driven tumors. PORCN, a membrane-bound O-acyltransferase (MBOAT), is + required for the palmitoylation of Wnt ligands, and plays a key role in Wnt + ligand secretion and activity. Wnt signaling is dysregulated in a variety of + cancers and plays a key role in cancer cell survival. + termDef: + term: >- + Porcupine Inhibitor XNW7201 + source: NCIt + cde_id: C172189 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172189" + term_id: C172189 + term_version: 20.10d + +porocarcinoma: + common: + description: >- + A carcinoma with eccrine differentiation arising from the sweat glands. It may + arise de novo or as a malignant transformation of a pre-existing poroma. It + usually grows in the legs, buttocks, feet, and trunk and usually presents as + an ulcerative plaque. It is characterized by the presence of intraepidermal + and dermal nests of malignant epithelial cells. It may recur after excision + and metastasize to the lymph nodes and less frequently to distal anatomic sites. + termDef: + term: >- + Porocarcinoma + source: NCIt + cde_id: C5560 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5560" + term_id: C5560 + term_version: 20.05a + +portugal: + common: + description: >- + A country in southwestern Europe, bordering the North Atlantic Ocean, west of + Spain. + termDef: + term: >- + Portugal + source: NCIt + cde_id: C17006 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17006" + term_id: C17006 + term_version: 19.12e + +positive: + common: + description: >- + A finding of abnormality following an examination or observation confirming + something, such as the presence of a disease, condition, or microorganism. + termDef: + term: >- + Positive Finding + source: NCIt + cde_id: C38758 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38758" + term_id: C38758 + term_version: 20.10d + +post_transplant_lymphoproliferative_disorder_nos: + common: + description: >- + Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) + or clonal (malignant) proliferation of lymphoid cells that develops as a consequence + of immunosuppression in a recipient of a solid organ or bone marrow allograft. + PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven + polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas + of predominantly B-cell or less often T-cell type. (WHO, 2001) + termDef: + term: >- + Post-Transplant Lymphoproliferative Disorder + source: NCIt + cde_id: C4727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4727" + term_id: C4727 + term_version: 20.05a + +postcricoid_region: + common: + description: >- + The portion of the hypopharynx that is located posteriorly to the larynx. + termDef: + term: >- + Postcricoid Region + source: NCIt + cde_id: C54221 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54221" + term_id: C54221 + term_version: 20.05a + +posterior_mediastinum: + common: + description: >- + The part of the lower portion of the mediastinum that is located behind the + pericardium. + termDef: + term: >- + Posterior Mediastinum + source: NCIt + cde_id: C33368 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33368" + term_id: C33368 + term_version: 20.05a + +posterior_wall_of_bladder: + common: + description: >- + The posterior aspect of the bladder wall. + termDef: + term: >- + Posterior Wall of the Bladder + source: NCIt + cde_id: C12335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12335" + term_id: C12335 + term_version: 20.05a + +posterior_wall_of_hypopharynx: + common: + description: >- + The region of the hypopharynx demarcated by a plane drawn at the level of the + tip of the epiglottis to a plane at the inferior border of the cricoid. + termDef: + term: >- + Posterior Wall of the Hypopharynx + source: NCIt + cde_id: C12249 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12249" + term_id: C12249 + term_version: 20.05a + +posterior_wall_of_nasopharynx: + common: + description: >- + The dorsal portion of the nasopharyngeal cavity that contains the pharyngeal + tonsil. + termDef: + term: >- + Posterior Wall of the Nasopharynx + source: NCIt + cde_id: C12243 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12243" + term_id: C12243 + term_version: 20.05a + +posterior_wall_of_oropharynx: + common: + description: >- + The dorsal portion of the oropharyngeal cavity that is formed by the muscular + pharyngeal wall comprising the superior and middle pharyngeal constrictor muscles. + termDef: + term: >- + Posterior Wall of the Oropharynx + source: NCIt + cde_id: C12240 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12240" + term_id: C12240 + term_version: 20.05a + +pot1: + common: + description: >- + This gene plays a role in the regulation of telomere length. + termDef: + term: >- + POT1 Gene + source: NCIt + cde_id: C107655 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107655" + term_id: C107655 + term_version: 20.10d + +pou2af1: + common: + description: >- + This gene is involved in both humoral immunity and transcriptional regulation. + termDef: + term: >- + POU2AF1 Gene + source: NCIt + cde_id: C97730 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97730" + term_id: C97730 + term_version: 20.10d + +pou5f1: + common: + description: >- + This gene plays a role in early mammalian development. + termDef: + term: >- + POU5F1 Gene + source: NCIt + cde_id: C61140 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61140" + term_id: C61140 + term_version: 20.10d + +ppar_alpha_antagonist_tpst1120: + common: + description: >- + An orally bioavailable, small molecule, selective and competitive antagonist + of peroxisome proliferator activated receptor alpha (PPARa), with potential + immunomodulating and antineoplastic activities. Upon oral administration, TPST-1120 + targets, binds to and blocks the activity of PPARa, thereby blocking transcription + of PPARa target genes leading to an intracellular metabolism shift from fatty + acid oxidation (FAO) to glycolysis in FAO-dependent tumors and reducing the + production of fatty acids in the tumor microenvironment (TME). As fatty acids + are essential for tumor cell growth in FAO-dependent tumor cells and are needed + for the metabolism of suppressive immune cells in the TME, including regulatory + T-cells (Tregs), reducing the amount of fatty acids leads to a direct killing + of FAO-dependent tumor cells. It also skews macrophages from the immune suppressive + M2 phenotype to an effector M1 phenotype and facilitates the cytotoxicity of + immune effector cells, thereby stimulating an anti-tumor immune response and + further killing tumor cells. TPST-1120 also restores the natural inhibitor of + angiogenesis thrombospondin-1 (TSP-1) and stimulator of interferon genes (STING) + in the TME. PPARa, a ligand-activated nuclear transcription factor and metabolic + checkpoint, regulates the expression of FAO genes and lipid metabolism. It plays + a key role in immunosuppression in the TME. FAO is a metabolic pathway essential + to tumor growth, survival and immunosuppression. + termDef: + term: >- + PPAR Alpha Antagonist TPST-1120 + source: NCIt + cde_id: C169105 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C169105" + term_id: C169105 + term_version: 20.10d + +pparg: + common: + description: >- + This gene plays a regulatory role in adipocyte differentiation. + termDef: + term: >- + PPARG Gene + source: NCIt + cde_id: C24689 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24689" + term_id: C24689 + term_version: 20.10d + +ppdpseudoprogression: + common: + description: >- + A radiologic finding observed during magnetic resonance imaging of brain glioblastoma, + following concurrent radiotherapy and temozolomide treatment or vaccine therapy. + It refers to the false positive finding of progression and enhancement of the + lesion. It is considered a treatment effect due to tumor cell necrosis and subsequent + edema formation and increased vascular permeability. + termDef: + term: >- + Pseudoprogression + source: NCIt + cde_id: C98298 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98298" + term_id: C98298 + term_version: 20.05a + +ppfibp1: + common: + description: >- + This gene plays a role in protein-protein interactions and cell-matrix adhesion. + termDef: + term: >- + PPFIBP1 Gene + source: NCIt + cde_id: C101494 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101494" + term_id: C101494 + term_version: 20.10d + +ppm1d: + common: + description: >- + This gene plays a role in the modulation of cell cycle arrest. + termDef: + term: >- + PPM1D Gene + source: NCIt + cde_id: C88179 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C88179" + term_id: C88179 + term_version: 20.10d + +ppnet: + common: + description: >- + A small round cell tumor with neural differentiation arising from the soft tissues + or bone. + termDef: + term: >- + Peripheral Primitive Neuroectodermal Tumor + source: NCIt + cde_id: C9341 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9341" + term_id: C9341 + term_version: 20.05a + +ppp2r1a: + common: + description: >- + This gene plays a role in the regulation of cell growth and division. + termDef: + term: >- + PPP2R1A Gene + source: NCIt + cde_id: C92536 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92536" + term_id: C92536 + term_version: 20.10d + +ppp6c: + common: + description: >- + This gene plays a role in both protein dephosphorylation and signaling. + termDef: + term: >- + PPP6C Gene + source: NCIt + cde_id: C102901 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102901" + term_id: C102901 + term_version: 20.10d + +pralsetinib: + common: + description: >- + An orally bioavailable selective inhibitor of mutant forms of and fusion products + involving the proto-oncogene receptor tyrosine kinase RET, with potential antineoplastic + activity. Upon administration, pralsetinib binds to and targets various RET + mutants and RET-containing fusion product. RET gene mutations and translocations + result in the upregulation and/or activation of RET tyrosine kinase activity + in various cancer cell types; dysregulation of RET activity plays a key role + in the development and regression of these cancers. + termDef: + term: >- + Pralsetinib + source: NCIt + cde_id: C132295 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132295" + term_id: C132295 + term_version: 20.10d + +praluzatamab_ravtansine: + common: + description: >- + A probody drug conjugate (PDC) composed of a recombinant antibody targeting + the tumor-associated antigen (TAA) CD166, which is masked by a cleavable masking + peptide, and conjugated to the cytotoxic agent maytansinoid DM4, with potential + antineoplastic activity. Upon administration of praluzatamab ravtansine and + migration to the tumor microenvironment (TME), the cleavable masking peptide, + which prevent anti-CD166 antibody binding to the CD166 expressed on both normal + cells and tumor cells, is proteolytically cleaved by tumor-associated proteases + that are specifically present in the TME. This enables the anti-CD166 antibody + moiety of CX-2009 to selectively bind to, be internalized by, and deliver DM4 + into CD166-expressing tumor cells. Following internalization, DM4 is released, + binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting + in inhibition of cell division and cell growth of CD166-expressing tumor cells. + The masking peptide prevents binding of the anti-CD166 antibody to CD166 in + normal tissues, thereby minimizing toxicities. + termDef: + term: >- + Praluzatamab Ravtansine + source: NCIt + cde_id: C134697 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C134697" + term_id: C134697 + term_version: 20.10d + +prcc: + common: + description: >- + This gene may be involved in transcriptional regulation. + termDef: + term: >- + PRCC Gene + source: NCIt + cde_id: C70994 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70994" + term_id: C70994 + term_version: 20.10d + +prdm1: + common: + description: >- + This gene is involved in repression of transcription. It plays a role in the + formation of pre-plasma memory B cells and immunoglobulin-secreting plasma cells. + termDef: + term: >- + PRDM1 Gene + source: NCIt + cde_id: C24692 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24692" + term_id: C24692 + term_version: 20.10d + +prdm16: + common: + description: >- + This gene plays a role in both transcriptional regulation and adipocyte differentiation. + termDef: + term: >- + PRDM16 Gene + source: NCIt + cde_id: C97736 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97736" + term_id: C97736 + term_version: 20.10d + +prdm2: + common: + description: >- + This gene is involved in both methylation of histone H3 and transcriptional + regulation. + termDef: + term: >- + PRDM2 Gene + source: NCIt + cde_id: C143121 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143121" + term_id: C143121 + term_version: 20.10d + +preb_all: + common: + description: >- + An acute lymphoblastic leukemia that originates from pre-B lymphocytes. The + pre-B lymphoblasts contain cytoplasmic immunoglobulin. + termDef: + term: >- + Pre-B Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27798" + term_id: C27798 + term_version: 20.05a + +precancerous_melanosis_nos: + common: + description: >- + Precancerous Melanosis + termDef: + term: >- + Precancerous Melanosis + source: NCIt + cde_id: C4233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4233 " + term_id: C4233 + term_version: 20.05a + +precursor_bcell_lymphoblastic_leukemia: + common: + description: >- + The most frequent type of acute lymphoblastic leukemia. Approximately 75% of + cases occur in children under six years of age. This is a good prognosis leukemia. In + the pediatric age group the complete remission rate is approximately 95% and + the disease free survival rate is 70%. Approximately 80% of children appear + to be cured. In the adult age group the complete remission rate is 60-85%. (WHO, + 2001) + termDef: + term: >- + B Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C8644 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8644 " + term_id: C8644 + term_version: 20.05a + +precursor_bcell_lymphoblastic_lymphoma: + common: + description: >- + An uncommon type of lymphoma. It constitutes approximately 10% of cases of + lymphoblastic lymphoma. Approximately 75% of cases reported in a literature + review involved patients who were less than 18 years of age. The most commonly + affected sites are the skin, bone, soft tissue, and lymph nodes. It has a high + remission rate with a median survival of approximately 60 months. (WHO, 2001) + termDef: + term: >- + B Lymphoblastic Lymphoma + source: NCIt + cde_id: C8868 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8868" + term_id: C8868 + term_version: 20.05a + +precursor_cell_lymphoblastic_leukemia_nos: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +precursor_cell_lymphoblastic_leukemia_not_phenotyped: + common: + description: >- + Leukemia with an acute onset, characterized by the presence of lymphoblasts + in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic + leukemia and acute T lymphoblastic leukemia. + termDef: + term: >- + Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3167" + term_id: C3167 + term_version: 20.05a + +precursor_cell_lymphoblastic_lymphoma_nos: + common: + description: >- + A lymphoma composed of immature small to medium-sized precursor lymphoid cells + (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma. + termDef: + term: >- + Lymphoblastic Lymphoma + source: NCIt + cde_id: C9360 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9360" + term_id: C9360 + term_version: 20.05a + +precursor_tcell_lymphoblastic_leukemia: + common: + description: >- + Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood + cases and 25% of adult cases. It is more common in males than females. (WHO, + 2001) + termDef: + term: >- + T Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C3183 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3183" + term_id: C3183 + term_version: 20.05a + +precursor_tcell_lymphoblastic_lymphoma: + common: + description: >- + The most frequent type of lymphoblastic lymphoma. It comprises approximately + 85-90% of cases. It is more frequently seen in adolescent males. It frequently + presents with a mass lesion in the mediastinum. Pleural effusions are common. (WHO, + 2001) + termDef: + term: >- + T Lymphoblastic Lymphoma + source: NCIt + cde_id: C6919 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6919" + term_id: C6919 + term_version: 20.05a + +preleukemia: + common: + description: >- + A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis + in one or more of the hematopoietic cell lines. The dysplasia may be accompanied + by an increase in myeloblasts, but the number is less than 20%, which, according + to the WHO guidelines, is the requisite threshold for the diagnosis of acute + myeloid leukemia. It may occur de novo or as a result of exposure to alkylating + agents and/or radiotherapy. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome + source: NCIt + cde_id: C3247 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3247" + term_id: C3247 + term_version: 20.05a + +preleukemic_syndrome: + common: + description: >- + A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis + in one or more of the hematopoietic cell lines. The dysplasia may be accompanied + by an increase in myeloblasts, but the number is less than 20%, which, according + to the WHO guidelines, is the requisite threshold for the diagnosis of acute + myeloid leukemia. It may occur de novo or as a result of exposure to alkylating + agents and/or radiotherapy. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome + source: NCIt + cde_id: C3247 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3247" + term_id: C3247 + term_version: 20.05a + +premalignant: + common: + description: >- + A neoplasm that is composed of dysplastic cells and there is no morphologic + evidence of infiltration of the surrounding tissues. + termDef: + term: >- + Premalignant Neoplasm + source: NCIt + cde_id: C36032 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36032" + term_id: C36032 + term_version: 20.05a + +prepreb_all: + common: + description: >- + Acute lymphoblastic leukemia of early B-lineage. + termDef: + term: >- + Pre-Pre-B Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27799 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27799" + term_id: C27799 + term_version: 20.05a + +prepuce: + common: + description: >- + A covering fold of skin, often used alone to designate the preputium penis. + termDef: + term: >- + Prepuce + source: NCIt + cde_id: C12323 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12323" + term_id: C12323 + term_version: 20.05a + +present: + common: + description: >- + Being or existing in a specified place or at the specified time. + termDef: + term: >- + Present + source: NCIt + cde_id: C25626 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25626" + term_id: C25626 + term_version: 20.05a + pathology_detail: + non_nodal_regional_disease: + description: >- + A finding of abnormality following an examination or observation confirming + something, such as the presence of a disease, condition, or microorganism. + termDef: + term: >- + Positive Finding + source: NCIt + cde_id: C38758 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38758" + term_id: C38758 + term_version: 20.10d + anaplasia_present_type: + description: >- + A morphologic finding indicating the presence of a malignant cellular infiltrate + characterized by the presence of large pleomorphic cells, necrosis, and high + mitotic activity in a tissue sample. + termDef: + term: >- + Anaplastic Lesion + source: NCIt + cde_id: C36113 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36113" + term_id: C36113 + term_version: 20.05a + transglottic_extension: + description: >- + Extension of a laryngeal tumor beyond the glottic opening into the ventricles + and vocal cords. + termDef: + term: >- + Transglottic Extension of Laryngeal Tumor + source: NCIt + cde_id: C160996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C160996" + term_id: C160996 + term_version: 20.05a + +pret_all: + common: + description: >- + Pre T-ALL + termDef: + term: >- + Pre T-ALL + source: NCIt + cde_id: C27261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27261" + term_id: C27261 + term_version: 20.05a + +prex2: + common: + description: >- + This gene is involved in guanine nucleotide exchange. + termDef: + term: >- + PREX2 Gene + source: NCIt + cde_id: C102517 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102517" + term_id: C102517 + term_version: 20.10d + +prf1: + common: + description: >- + This gene is involved in cytolysis. + termDef: + term: >- + PRF1 Gene + source: NCIt + cde_id: C97739 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97739" + term_id: C97739 + term_version: 20.10d + +primary: + common: + description: >- + A tumor at the original site of origin. + termDef: + term: >- + Primary Neoplasm + source: NCIt + cde_id: C8509 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8509" + term_id: C8509 + term_version: 20.05a + +primary_amyloidosis: + common: + description: >- + A plasma cell neoplasm that secretes an abnormal immunoglobulin, which deposits + in tissues and forms a beta-pleated sheet structure that binds Congo red dye + with characteristic birefringence. (WHO, 2001) + termDef: + term: >- + Primary Amyloidosis + source: NCIt + cde_id: C3819 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3819" + term_id: C3819 + term_version: 20.05a + +primary_cutaneous_anaplastic_large_cell_lymphoma: + common: + description: >- + An anaplastic large cell lymphoma limited to the skin at the time of diagnosis. Most + patients present with solitary or localized skin lesions, which may be tumors, + nodules or papules. The t(2;5) translocation that is present in many cases + of systemic anaplastic large cell lymphoma, is not found in this disease. (WHO, + 2001) + termDef: + term: >- + Primary Cutaneous Anaplastic Large Cell Lymphoma + source: NCIt + cde_id: C6860 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6860" + term_id: C6860 + term_version: 20.05a + +primary_cutaneous_cd30_large_tcell_lymphoma: + common: + description: >- + An anaplastic large cell lymphoma limited to the skin at the time of diagnosis. Most + patients present with solitary or localized skin lesions, which may be tumors, + nodules or papules. The t(2;5) translocation that is present in many cases + of systemic anaplastic large cell lymphoma, is not found in this disease. (WHO, + 2001) + termDef: + term: >- + Primary Cutaneous Anaplastic Large Cell Lymphoma + source: NCIt + cde_id: C6860 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6860" + term_id: C6860 + term_version: 20.05a + +primary_cutaneous_cd30_tcell_lymphoproliferative_disorder: + common: + description: >- + This entity represents a spectrum of lymphoproliferative disorders characterized + by CD30 (Ki-1)-positive cutaneous T-cell infiltrates. The two ends of the spectrum + include lymphomatoid papulosis (benign end) and primary cutaneous anaplastic + large cell lymphoma (malignant end). Borderline lesions are also included in + this spectrum. (WHO, 2001) + termDef: + term: >- + Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder + source: NCIt + cde_id: C7195 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7195" + term_id: C7195 + term_version: 20.05a + +primary_cutaneous_cd4positive_smallmedium_tcell_lymphoma: + common: + description: >- + A primary cutaneous T-cell lymphoproliferative disorder. It usually presents + with a solitary plaque or tumor on the face, neck, or upper trunk. Morphologically, + it is composed of small to medium-sized CD4-positive, CD8-negative, and CD30-negative + pleomorphic T-lymphocytes. A small number of large pleomorphic T-lymphocytes + may also be present. The lymphocytic infiltrate is dermal. Focal epidermotropism + and subcutaneous involvement may be present. The clinical behavior is almost + always indolent and most patients present with localized disease. + termDef: + term: >- + Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder + source: NCIt + cde_id: C45366 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45366" + term_id: C45366 + term_version: 20.05a + +primary_cutaneous_cd8positive_aggressive_epidermotropic_cytotoxic_tcell_lymphoma: + common: + description: >- + An aggressive, epidermotropic primary cutaneous T-cell lymphoma. It is characterized + by the presence of eruptive papules and nodules, or tumors, which may be localized + or disseminated. Morphologically, it is composed of small to medium-sized, + or medium-sized to large, CD8-positive T-lymphocytes with pleomorphic or blastic + nuclei. Epidermotropism is often pronounced. Angiocentricity and angioinvasion + may be present. + termDef: + term: >- + Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell + Lymphoma + source: NCIt + cde_id: C45339 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45339" + term_id: C45339 + term_version: 20.05a + +primary_cutaneous_dlbcl_leg_type: + common: + description: >- + An aggressive primary cutaneous B-cell lymphoma, usually involving the lower + leg. It is composed of a generally monotonous proliferation of immunoblasts, + or less frequently centroblasts, with few admixed reactive cells. This type + of lymphoma occurs most often in elderly women who present with rapidly growing + tumors, usually on one or both legs. Dissemination to extracutaneous sites + is frequent. Treatment with combination chemotherapy is usually required. + termDef: + term: >- + Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type + source: NCIt + cde_id: C45194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45194" + term_id: C45194 + term_version: 20.05a + +primary_cutaneous_follicle_centre_lymphoma: + common: + description: >- + A primary lymphoma of the skin composed of various numbers of small and large + irregular neoplastic follicle center cells. Its morphologic pattern can be + nodular, diffuse, or nodular and diffuse. It presents with solitary or grouped + plaques and tumors, and it usually involves the scalp, forehead, or trunk. It + rarely involves the legs. This type of cutaneous lymphoma tends to remain localized + to the skin. + termDef: + term: >- + Primary Cutaneous Follicle Center Lymphoma + source: NCIt + cde_id: C7217 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7217" + term_id: C7217 + term_version: 20.05a + +primary_cutaneous_gammadelta_tcell_lymphoma: + common: + description: >- + An aggressive cutaneous lymphoma of mature, activated gamma/delta T-lymphocytes. It + usually presents with disseminated plaques and nodules. Involvement of mucosal + sites is frequent. However, involvement of lymph nodes, spleen, or bone marrow + is uncommon. Morphologically, there are three patterns of cutaneous involvement: + epidermotropic, dermal, and subcutaneous. Often, more than one pattern may + co-exist in a single biopsy specimen, or may be present in different biopsy + specimens from the same patient. The lymphocytic infiltrate is composed of + medium- to large-sized lymphocytes expressing CD56. Most cases lack both CD4 + and CD8, although CD8 may be present in some cases. This group of lymphomas + includes cases previously known as subcutaneous panniculitis-like T-cell lymphoma + with a gamma/delta phenotype. + termDef: + term: >- + Primary Cutaneous Gamma-Delta T-Cell Lymphoma + source: NCIt + cde_id: C45340 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45340" + term_id: C45340 + term_version: 20.05a + +primary_cutaneous_neuroendocrine_carcinoma: + common: + description: >- + A rare malignant cutaneous tumor seen in elderly patients. Its usual location + is on the head, neck and extremities. The tumor is composed of small round cells + with scanty cytoplasm arranged in a trabecular pattern, or in ill-defined nodules + or in a diffuse pattern. The tumor cells contain cytoplasmic membrane-bound + dense core granules resembling neurosecretory granules. There is strong evidence + implicating Merkel cell polyomavirus in a majority of cases of Merkel cell carcinoma. + termDef: + term: >- + Merkel Cell Carcinoma + source: NCIt + cde_id: C9231 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9231" + term_id: C9231 + term_version: 20.05a + +primary_effusion_lymphoma: + common: + description: >- + A large B-cell lymphoma usually presenting as a serous effusion without detectable + tumor masses. It is universally associated with human herpes virus 8 (HHV8), + also called Kaposi sarcoma-associated herpesvirus. It mostly occurs in the + setting of immunodeficiency. The most common sites of involvement are the pleural, + pericardial, and peritoneal cavities. Rare HHV8-positive lymphomas indistinguishable + from primary effusion lymphomas (PEL) present as solid tumor masses, and have + been termed extracavitary PEL. The prognosis is extremely unfavorable. (WHO + 2017) + termDef: + term: >- + Primary Effusion Lymphoma + source: NCIt + cde_id: C6915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6915" + term_id: C6915 + term_version: 20.05a + +primary_myelofibrosis: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, + proliferation of atypical megakaryocytes and granulocytes in the bone marrow, + anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001) + termDef: + term: >- + Primary Myelofibrosis + source: NCIt + cde_id: C2862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2862" + term_id: C2862 + term_version: 20.05a + +primary_serous_papillary_carcinoma_of_peritoneum: + common: + description: >- + A rare, serous papillary adenocarcinoma that arises from the lining of the peritoneum. + It affects females. The clinical behavior and pathologic characteristics are + similar to the serous papillary adenocarcinoma that arises from the ovary. + termDef: + term: >- + Primary Peritoneal Serous Papillary Adenocarcinoma + source: NCIt + cde_id: C7695 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7695" + term_id: C7695 + term_version: 20.05a + +primitive_neuroectodermal_tumor_nos: + common: + description: >- + A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm + constitutes the portion of the ectoderm of the early embryo that gives rise + to the central and peripheral nervous systems and includes some glial cell precursors. + termDef: + term: >- + Primitive Neuroectodermal Tumor + source: NCIt + cde_id: C3716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3716" + term_id: C3716 + term_version: 20.05a + +prkaca: + common: + description: >- + This gene is involved in the regulation of diverse cell processes including + cell growth, proliferation, differentiation and motility. + termDef: + term: >- + PRKACA Gene + source: NCIt + cde_id: C38409 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38409" + term_id: C38409 + term_version: 20.10d + +prkar1a: + common: + description: >- + This gene plays a role in the regulation of protein kinase A. + termDef: + term: >- + PRKAR1A Gene + source: NCIt + cde_id: C97742 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97742" + term_id: C97742 + term_version: 20.10d + +prkcb: + common: + description: >- + This gene is involved in diverse cell processes such as apoptosis, B cell activation + and endothelial cell proliferation. + termDef: + term: >- + PRKCB Gene + source: NCIt + cde_id: C39597 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39597" + term_id: C39597 + term_version: 20.10d + +prmt5_inhibitor_prt811: + common: + description: >- + An orally available small molecule inhibitor of protein arginine methyltransferase + 5 (PRMT5), with potential antiproliferative and antineoplastic activities. Upon + oral administration, PRMT5 inhibitor PRT811 selectively binds to PRMT5 and inhibits + its function. By inhibiting its methyltransferase activity, levels of both monomethylated + and dimethylated arginine residues in histones H2A, H3 and H4 are decreased. + This modulates the expression of genes involved in several cellular processes, + including cellular proliferation. This may increase the expression of antiproliferative + genes and/or decrease the expression of genes that promote cell proliferation, + which may lead to decreased growth of rapidly proliferating cells, including + cancer cells. PRMT5, a type II methyltransferase that catalyzes the formation + of both omega-N monomethylarginine (MMA) and symmetric dimethylarginine (sDMA) + on histones and a variety of other protein substrates involved in signal transduction + and cellular transcription, is overexpressed in several neoplasms. Elevated + levels are associated with decreased patient survival. + termDef: + term: >- + PRMT5 Inhibitor PRT811 + source: NCIt + cde_id: C168531 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168531" + term_id: C168531 + term_version: 20.10d + +prob_all: + common: + description: >- + An acute lymphoblastic leukemia that originates from pre-B lymphocytes. The + pre-B lymphoblasts contain cytoplasmic immunoglobulin. + termDef: + term: >- + Pre-B Acute Lymphoblastic Leukemia + source: NCIt + cde_id: C27798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27798" + term_id: C27798 + term_version: 20.05a + +prolactinoma: + common: + description: >- + An adenoma of the anterior lobe of the pituitary gland that produces prolactin. It + is the most common type of pituitary gland adenomas and it is associated with + hyperprolactinemia. Clinical manifestations include amenorrhea, galactorrhea, + impotence, headache, and visual disturbances. + termDef: + term: >- + Lactotroph Adenoma + source: NCIt + cde_id: C3342 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3342" + term_id: C3342 + term_version: 20.05a + +prolgolimab: + common: + description: >- + A monoclonal antibody directed against the negative immunoregulatory human cell + receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + prolgolimab binds to and inhibits PD-1 and its downstream signaling pathways. + This may restore immune function through the activation of T-cells and cell-mediated + immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin + superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that + negatively regulates T-cell activation and effector function when activated + by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays + an important role in tumor evasion from host immunity. + termDef: + term: >- + Prolgolimab + source: NCIt + cde_id: C148155 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148155" + term_id: C148155 + term_version: 20.10d + +proliferating_trichilemmal_cyst: + common: + description: >- + A neoplasm with tricholemmal differentiation. It affects women more frequently + than men. It usually presents on the scalp as a solitary, multilobular, large, + exophytic mass. Morphologically, it may display benign cytological features + and appear as a circumscribed solid-cystic neoplasm or it may display malignant + characteristics and invasive features. Cases without malignant characteristics + usually have an indolent course. Complete surgical excision is recommended in + such cases to avoid recurrences and to allow complete examination of the specimen. + Cases with malignant characteristics may have a locally aggressive clinical + course, recur, or metastasize. + termDef: + term: >- + Proliferating Trichilemmal Tumor + source: NCIt + cde_id: C27125 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27125" + term_id: C27125 + term_version: 20.05a + +proliferating_trichilemmal_tumor: + common: + description: >- + A neoplasm with tricholemmal differentiation. It affects women more frequently + than men. It usually presents on the scalp as a solitary, multilobular, large, + exophytic mass. Morphologically, it may display benign cytological features + and appear as a circumscribed solid-cystic neoplasm or it may display malignant + characteristics and invasive features. Cases without malignant characteristics + usually have an indolent course. Complete surgical excision is recommended in + such cases to avoid recurrences and to allow complete examination of the specimen. + Cases with malignant characteristics may have a locally aggressive clinical + course, recur, or metastasize. + termDef: + term: >- + Proliferating Trichilemmal Tumor + source: NCIt + cde_id: C27125 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27125" + term_id: C27125 + term_version: 20.05a + +proliferative_dermal_lesion_in_congenital_nevus: + common: + description: >- + A benign proliferation of epithelioid or spindled melanocytes usually in the + upper or mid dermis in a background of congenital melanocytic nevus. The congenital + melanocytic nevus is usually of the deep type, involving the dermis and extending + into the subcutaneous tissue. It presents as a dark plaque or nodule above a + giant congenital melanocytic nevus. + termDef: + term: >- + Proliferative Nodules in Congenital Melanocytic Nevus + source: NCIt + cde_id: C66755 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66755" + term_id: C66755 + term_version: 20.05a + +proliferative_polycythemia: + common: + description: >- + A chronic myeloproliferative neoplasm characterized by an increased red blood + cell production. The bone marrow is hypercellular due to a panmyelotic proliferation + typically characterized by pleomorphic megakaryocytes. The major symptoms are + related to hypertension, splenomegaly or to episodes of thrombosis and/or hemorrhage. + termDef: + term: >- + Polycythemia Vera + source: NCIt + cde_id: C3336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3336" + term_id: C3336 + term_version: 20.05a + +prolymphocytes: + common: + description: >- + The determination of the number of prolymphocytes in a blood sample. + termDef: + term: >- + Prolymphocyte Count + source: NCIt + cde_id: C74620 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74620" + term_id: C74620 + term_version: 20.10d + +prolymphocytic_leukemia_bcell_type: + common: + description: >- + A malignant B-cell lymphoproliferative process affecting the blood, bone marrow, + and spleen. The B-prolymphocytes are medium-sized, round lymphoid cells with + prominent nucleoli. The B-prolymphocytes must exceed 55% of lymphoid cells + in the blood. Cases of transformed chronic lymphocytic leukemia (CLL) and CLL + with increased prolymphocytes are excluded. The prognosis is poor. (WHO, 2001) + termDef: + term: >- + B-Cell Prolymphocytic Leukemia + source: NCIt + cde_id: C4753 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4753" + term_id: C4753 + term_version: 20.05a + +prolymphocytic_leukemia_nos: + common: + description: >- + A mature B- or T- cell leukemia with progressive clinical course. It is characterized + by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) + in the peripheral blood, bone marrow, and spleen. + termDef: + term: >- + Prolymphocytic Leukemia + source: NCIt + cde_id: C3181 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3181" + term_id: C3181 + term_version: 20.05a + +prolymphocytic_leukemia_tcell_type: + common: + description: >- + An aggressive T-cell leukemia, characterized by the proliferation of small to + medium sized prolymphocytes with a mature T-cell phenotype, involving the blood, + bone marrow, lymph nodes, liver, spleen, and skin. (WHO, 2001) + termDef: + term: >- + T-Cell Prolymphocytic Leukemia + source: NCIt + cde_id: C4752 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4752" + term_id: C4752 + term_version: 20.05a + +promonocytes: + common: + description: >- + The determination of the number of promonocytes in a blood sample. + termDef: + term: >- + Promonocyte Count + source: NCIt + cde_id: C74621 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74621" + term_id: C74621 + term_version: 20.10d + +promyelocytes: + common: + description: >- + The determination of the number of promyelocytes present in a sample. + termDef: + term: >- + Promyelocyte Count + source: NCIt + cde_id: C74622 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74622" + term_id: C74622 + term_version: 20.10d + +prostaglandin_e2_ep4_receptor_inhibitor_an0025: + common: + description: >- + An orally bioavailable antagonist of the prostaglandin E2 (PGE2) receptor type + 4 (EP4; EP-4), with potential immunomodulating and antineoplastic activities. + Upon oral administration, AN0025 selectively targets, binds to and blocks the + activity of immunosuppressive tumor-associated myeloid cells (TAMCs) in the + microenvironment. This abolishes TAMC-dependent immunosuppression and reduces + tumor cell proliferation. The presence of immunosuppressive myeloid cells in + certain tumors is associated with a poor prognosis. + termDef: + term: >- + Prostaglandin E2 EP4 Receptor Inhibitor AN0025 + source: NCIt + cde_id: C129689 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129689" + term_id: C129689 + term_version: 20.10d + +prostate_cancer: + common: + description: >- + One of the most common malignant tumors afflicting men. The majority of carcinomas + arise in the peripheral zone and a minority occur in the central or the transitional + zone of the prostate gland. Grossly, prostatic carcinomas appear as ill-defined + yellow areas of discoloration in the prostate gland lobes. Adenocarcinomas represent + the overwhelming majority of prostatic carcinomas. Prostatic-specific antigen + (PSA) serum test is widely used as a screening test for the early detection + of prostatic carcinoma. Treatment options include radical prostatectomy, radiation + therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance + alone is an option for older patients with low-grade or low-stage disease. + termDef: + term: >- + Prostate Carcinoma + source: NCIt + cde_id: C4863 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4863" + term_id: C4863 + term_version: 19.12e + +prostate_gland: + common: + description: >- + The walnut shaped accessory sex gland of the male reproductive system. It is + located in the pelvis just below the bladder, surrounding the prostatic part + of the urethra. The prostate gland secretes a fluid which is part of the semen. + termDef: + term: >- + Prostate Gland + source: NCIt + cde_id: C12410 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12410" + term_id: C12410 + term_version: 20.05a + +prostatespecific_antigen_psa: + common: + description: >- + Prostate-specific antigen (261 aa, ~29 kDa) is encoded by the human KLK3 gene. + This protein plays a role in both proteolysis and seminal fluid liquefaction. + termDef: + term: >- + Prostate-Specific Antigen + source: NCIt + cde_id: C17525 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17525" + term_id: C17525 + term_version: 20.10d + +prostatic_intraepithelial_neoplasia_grade_iii: + common: + description: >- + High grade prostatic intraepithelial neoplasia characterized by the presence + of severe architectural and cytologic abnormalities. + termDef: + term: >- + Grade III Prostatic Intraepithelial Neoplasia + source: NCIt + cde_id: C3642 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3642" + term_id: C3642 + term_version: 20.05a + +prot_all: + common: + description: >- + Pre T-ALL + termDef: + term: >- + Pre T-ALL + source: NCIt + cde_id: C27261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27261" + term_id: C27261 + term_version: 20.05a + +protein: + common: + description: >- + A group of complex organic macromolecules composed of one or more chains (linear + polymers) of alpha-L-amino acids linked by peptide bonds and ranging in size + from a few thousand to over 1 million Daltons. Proteins are fundamental genetically + encoded components of living cells with specific structures and functions dictated + by amino acid sequence. + termDef: + term: >- + Protein + source: NCIt + cde_id: C17021 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17021" + term_id: C17021 + term_version: 20.10d + +protein_altering_variant: + common: + description: >- + A point mutation occurring within the protein-coding region of a gene, and which + codes for a different amino acid than expected. + termDef: + term: >- + Missense Mutation + source: NCIt + cde_id: C18133 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18133" + term_id: C18133 + term_version: 20.10d + +protein_tyrosine_kinase_2_inhibitor_in10018: + common: + description: >- + An orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase + protein tyrosine kinase 2 (focal adhesion kinase 1; FAK1; FAK: PTK2) with potential + antineoplastic activity. Upon oral administration, IN10018 targets and inhibits, + in an adenosine triphosphate (ATP)-competitive manner, PTK2. This prevents PTK2-mediated + downstream signaling and inhibits migration, proliferation, invasion, and survival + in PTK2-overexpressing tumor cells. The cytoplasmic tyrosine kinase PTK2, a + signal transducer for integrins overexpressed in various tumor cell types, is + involved in tumor cell invasion, migration and proliferation. + termDef: + term: >- + Protein Tyrosine Kinase 2 Inhibitor IN10018 + source: NCIt + cde_id: C166122 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166122" + term_id: C166122 + term_version: 20.10d + +protoplasmic_astrocytoma: + common: + description: >- + A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic + astrocytes showing a small cell body with few, flaccid processes with a low + content of glial filaments and scant GFAP expression. This lesion is not well + defined and is considered by some authors as an occasional histopathological + feature rather than a reproducibly identifiable variant. When occurring in children, + this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. + (Adapted from WHO) + termDef: + term: >- + Protoplasmic Astrocytoma + source: NCIt + cde_id: C4320 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4320" + term_id: C4320 + term_version: 20.05a + +prpartial_response: + common: + description: >- + A finding indicating that there is a decrease in the size and the extent of + tissue involvement by a malignant tumor in a patient. + termDef: + term: >- + Partial Remission + source: NCIt + cde_id: C18058 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18058" + term_id: C18058 + term_version: 20.05a + +prpf40b: + common: + description: >- + This gene may be involved in mRNA splicing. + termDef: + term: >- + PRPF40B Gene + source: NCIt + cde_id: C143090 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143090" + term_id: C143090 + term_version: 20.10d + +prrx1: + common: + description: >- + This gene plays a role in both transcriptional regulation and muscle cell development. + termDef: + term: >- + PRRX1 Gene + source: NCIt + cde_id: C98030 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98030" + term_id: C98030 + term_version: 20.10d + +psammomatous_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of psammoma bodies that + predominate over the meningeal cells. + termDef: + term: >- + Psammomatous Meningioma + source: NCIt + cde_id: C4331 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4331" + term_id: C4331 + term_version: 20.05a + +psammomatous_schwannoma: + common: + description: >- + A benign, usually encapsulated slow growing tumor composed of Schwann cells. It + affects peripheral and cranial nerves. It recurs infrequently and only rare + cases associated with malignant transformation have been reported. + termDef: + term: >- + Schwannoma + source: NCIt + cde_id: C3269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3269" + term_id: C3269 + term_version: 20.05a + +pseudomucinous_adenocarcinoma: + common: + description: >- + An invasive adenocarcinoma characterized by cystic changes and the presence + of malignant glandular cells which contain intracytoplasmic mucin. It may arise + from the ovary, pancreas, appendix, and lung. + termDef: + term: >- + Mucinous Cystadenocarcinoma + source: NCIt + cde_id: C3776 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3776" + term_id: C3776 + term_version: 20.05a + +pseudomucinous_cystadenocarcinoma_nos: + common: + description: >- + An invasive adenocarcinoma characterized by cystic changes and the presence + of malignant glandular cells which contain intracytoplasmic mucin. It may arise + from the ovary, pancreas, appendix, and lung. + termDef: + term: >- + Mucinous Cystadenocarcinoma + source: NCIt + cde_id: C3776 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3776" + term_id: C3776 + term_version: 20.05a + +pseudomucinous_cystadenoma_nos: + common: + description: >- + A benign or low malignant potential cystic epithelial neoplasm composed of cells + which contain intracytoplasmic mucin. It may arise from the ovary, pancreas, + appendix, and lung. + termDef: + term: >- + Mucinous Cystadenoma + source: NCIt + cde_id: C2973 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2973" + term_id: C2973 + term_version: 20.05a + +pseudomyxoma_peritonei: + common: + description: >- + A usually well differentiated mucinous adenocarcinoma of the peritoneum. The + majority of cases represent tumor spread from a primary low grade mucinous neoplasm + of the appendix. Cases of pseudomyxoma peritonei associated with mucinous adenocarcinomas + of the gallbladder, stomach, colon, rectum, pancreas, lung, breast, and fallopian + tubes have also been reported. In the past, the ovary has been considered as + a common primary site associated with pseudomyxoma peritonei. However, there + is recent evidence based on immunohistochemistry and molecular genetic analysis + suggesting that most cases of pseudomyxoma peritonei probably represent metastasis + from an appendiceal and not ovarian primary. + termDef: + term: >- + Pseudomyxoma Peritonei + source: NCIt + cde_id: C3345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3345" + term_id: C3345 + term_version: 20.05a + +pseudomyxoma_peritonei_with_unknown_primary_site: + common: + description: >- + A usually well differentiated mucinous adenocarcinoma of the peritoneum. The + majority of cases represent tumor spread from a primary low grade mucinous neoplasm + of the appendix. Cases of pseudomyxoma peritonei associated with mucinous adenocarcinomas + of the gallbladder, stomach, colon, rectum, pancreas, lung, breast, and fallopian + tubes have also been reported. In the past, the ovary has been considered as + a common primary site associated with pseudomyxoma peritonei. However, there + is recent evidence based on immunohistochemistry and molecular genetic analysis + suggesting that most cases of pseudomyxoma peritonei probably represent metastasis + from an appendiceal and not ovarian primary. + termDef: + term: >- + Pseudomyxoma Peritonei + source: NCIt + cde_id: C3345 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3345" + term_id: C3345 + term_version: 20.05a + +pseudosarcomatous_carcinoma: + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of spindle cells + and anaplastic morphologic features. Giant cells and a sarcomatous component + may also be present. + termDef: + term: >- + Sarcomatoid Carcinoma + source: NCIt + cde_id: C27004 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27004" + term_id: C27004 + term_version: 20.05a + +psip1: + common: + description: >- + This gene is involved in regulation of transcription. It also plays a role in + mediation of pre-mRNA splicing. + termDef: + term: >- + PSIP1 Gene + source: NCIt + cde_id: C20676 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20676" + term_id: C20676 + term_version: 20.10d + +psrpseudoresponse: + common: + description: >- + A marked decrease in contrast enhancement that is not due to actual tumor shrinkage, + but that may be due to anti-angiogenic therapy or an increase in steroid dosage. + termDef: + term: >- + Pseudoresponse + source: NCIt + cde_id: C131142 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131142" + term_id: C131142 + term_version: 20.05a + +ptch1: + common: + description: >- + This gene is involved in tumor suppression and mutations in this gene have been + associated with several cancers and cancer related diseases. + termDef: + term: >- + PTCH1 Gene + source: NCIt + cde_id: C18255 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18255" + term_id: C18255 + term_version: 20.10d + +pten: + common: + description: >- + This gene plays a role in signal transduction and apoptosis. It is also involved + in the regulation of cell cycle progression. + termDef: + term: >- + PTEN Gene + source: NCIt + cde_id: C18256 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18256" + term_id: C18256 + term_version: 20.10d + +ptk6: + common: + description: >- + This gene plays a role in signal transduction. + termDef: + term: >- + PTK6 Gene + source: NCIt + cde_id: C24701 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24701" + term_id: C24701 + term_version: 20.10d + +ptld_nos: + common: + description: >- + Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) + or clonal (malignant) proliferation of lymphoid cells that develops as a consequence + of immunosuppression in a recipient of a solid organ or bone marrow allograft. + PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven + polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas + of predominantly B-cell or less often T-cell type. (WHO, 2001) + termDef: + term: >- + Post-Transplant Lymphoproliferative Disorder + source: NCIt + cde_id: C4727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4727" + term_id: C4727 + term_version: 20.05a + +ptpn11: + common: + description: >- + This gene plays a role in the regulation of cell signaling. It is involved in + cell migration, metabolic control, mitogenic activation and gene transcription. + termDef: + term: >- + PTPN11 Gene + source: NCIt + cde_id: C26337 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26337" + term_id: C26337 + term_version: 20.10d + +ptpn13: + common: + description: >- + This gene is involved in both protein dephosphorylation and signal transduction. + termDef: + term: >- + PTPN13 Gene + source: NCIt + cde_id: C104212 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104212" + term_id: C104212 + term_version: 20.10d + +ptpn6: + common: + description: >- + This gene plays a role in the regulation of multiple signaling pathways in hematopoietic + cells. + termDef: + term: >- + PTPN6 Gene + source: NCIt + cde_id: C24708 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24708" + term_id: C24708 + term_version: 20.10d + +ptprb: + common: + description: >- + This gene is involved in dephosphorylation of proteins. + termDef: + term: >- + PTPRB Gene + source: NCIt + cde_id: C122909 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122909" + term_id: C122909 + term_version: 20.10d + +ptprc: + common: + description: >- + This gene plays a role in suppression of cytokine receptor signaling and the + regulation of signal transduction in lymphocytes. + termDef: + term: >- + PTPRC Gene + source: NCIt + cde_id: C24711 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24711" + term_id: C24711 + term_version: 20.10d + +ptprk: + common: + description: >- + This gene is involved in receptor signaling, cell-cell contact and cell migration. + termDef: + term: >- + PTPRK Gene + source: NCIt + cde_id: C106113 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106113" + term_id: C106113 + term_version: 20.10d + +ptprt: + common: + description: >- + This gene plays a role in the control of motor axon guidance. + termDef: + term: >- + PTPRT Gene + source: NCIt + cde_id: C24716 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24716" + term_id: C24716 + term_version: 20.10d + +puerto_rico: + common: + description: >- + An island between the Caribbean Sea and the North Atlantic Ocean, east of the + Dominican Republic and west of the British Virgin Islands. + termDef: + term: >- + Puerto Rico + source: NCIt + cde_id: C17043 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17043" + term_id: C17043 + term_version: 19.12e + +pulmonary_adenomatosis: + common: + description: >- + This is a non-human neoplastic process described in sheep. + termDef: + term: >- + Pulmonary Adenomatosis + source: NCIt + cde_id: C3763 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3763" + term_id: C3763 + term_version: 20.05a + +pulmonary_artery_intimal_sarcoma: + common: + description: >- + A sarcoma arising from the arterial intima of pulmonary arteries. + termDef: + term: >- + Pulmonary Artery Intimal Sarcoma + source: NCIt + cde_id: C142825 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142825" + term_id: C142825 + term_version: 20.05a + +pulmonary_blastoma: + common: + description: >- + A biphasic tumor that consists of fetal adenocarcinoma (typically low-grade) + and primitive mesenchymal stroma. Foci of specific mesenchymal differentiation + (osteosarcoma, chondrosarcoma, or rhabdomyosarcoma) may also be present, but + are not required for the diagnosis. Most patients are smokers. The prognosis + is very poor. (WHO 2015) + termDef: + term: >- + Pulmonary Blastoma + source: NCIt + cde_id: C3732 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3732" + term_id: C3732 + term_version: 20.05a + +pulmonary_myxoid_sarcoma_with_ewsr1creb1_translocation: + common: + description: >- + A sarcoma that arises from the lung. It is related to a bronchus and is often + predominantly endobronchial. It is characterized by the proliferation of round + and spindle cells within a myxoid stroma. It is associated with the presence + of an EWSR1-CREB1 fusion gene. + termDef: + term: >- + Pulmonary Myxoid Sarcoma with EWSR1-CREB1 Translocation + source: NCIt + cde_id: C142827 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142827" + term_id: C142827 + term_version: 20.05a + +pwwp2a: + common: + description: >- + This gene may play a role in protein-protein or protein-DNA interactions. + termDef: + term: >- + PWWP2A Gene + source: NCIt + cde_id: C122890 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122890" + term_id: C122890 + term_version: 20.10d + +pylorus: + common: + description: >- + The lower part of the stomach that connects to the duodenum. + termDef: + term: >- + Pylorus + source: NCIt + cde_id: C12260 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12260" + term_id: C12260 + term_version: 20.05a + +pyriform_sinus: + common: + description: >- + A pear-shaped fossa in the wall of the laryngeal pharynx lateral to the arytenoid + cartilage and medial to the lamina of the thyroid cartilage. + termDef: + term: >- + Pyriform Sinus + source: NCIt + cde_id: C33439 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33439" + term_id: C33439 + term_version: 20.05a + +pyruvate_kinase_m2_isoform_activator_tp1454: + common: + description: >- + An orally bioavailable activator of pyruvate kinase M2 isoform (PKM2), with + potential immunomodulating and antineoplastic activities. Upon oral administration, + PKM2 activator TP-1454 locks PKM2 into the active tetrameric form. This may + prevent the production of glycolytic intermediates by the less active dimer + form of PKM2, depleting the supply of glycolytic intermediates which are needed + for tumor cell growth. This may also inhibit immune suppression mediated by + the dimer form of PKM2. Altogether, this may slow tumor cell growth and enhance + anti-tumor immune responses, thereby inhibiting tumor cell proliferation. PKM2, + the predominant PK isoform found in tumor cells, is responsible for catalyzing + the last step of glycolysis. PKM2 plays a critical role in the metabolic changes + observed in cancer and immune cells and establishes a metabolic advantage for + tumor cells over the tumor immune microenvironment. + termDef: + term: >- + Pyruvate Kinase M2 Isoform Activator TP-1454 + source: NCIt + cde_id: C175380 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175380" + term_id: C175380 + term_version: 20.10d + +qatar: + common: + description: >- + A country in the Middle East, occupying a peninsula bordering the Persian Gulf + and Saudi Arabia. + termDef: + term: >- + Qatar + source: NCIt + cde_id: C17045 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17045" + term_id: C17045 + term_version: 19.12e + +qki: + common: + description: >- + This gene is involved in both the biosynthesis and maintenance of mRNA. + termDef: + term: >- + QKI Gene + source: NCIt + cde_id: C111937 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111937" + term_id: C111937 + term_version: 20.10d + +queyrat_erythroplasia: + common: + description: >- + Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. cN0: No palpable or + visibly enlarged inguinal lymph nodes. pN0: No regional lymph node metastasis. M0: + No distant metastasis. (AJCC 7th ed.) + termDef: + term: >- + Penile Carcinoma In Situ + source: NCIt + cde_id: C27790 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27790" + term_id: C27790 + term_version: 20.05a + +r0: + common: + description: >- + No detectable presence of residual tumor after treatment + termDef: + term: >- + Stage R0 + source: NCIt + cde_id: C139578 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139578" + term_id: C139578 + term_version: 20.05a + +r1: + common: + description: >- + Presence of microscopic residual tumor after treatment. + termDef: + term: >- + Stage R1 + source: NCIt + cde_id: C139579 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139579" + term_id: C139579 + term_version: 20.05a + +r2: + common: + description: >- + Presence of macroscopic residual tumor after treatment. + termDef: + term: >- + Stage R2 + source: NCIt + cde_id: C139580 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139580" + term_id: C139580 + term_version: 20.05a + +rabep1: + common: + description: >- + This gene is involved in the regulation of both GTPase activity and endocytosis. + termDef: + term: >- + RABEP1 Gene + source: NCIt + cde_id: C97751 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97751" + term_id: C97751 + term_version: 20.10d + +rac1: + common: + description: >- + This gene is involved in both cell motility and signal transduction. + termDef: + term: >- + RAC1 Gene + source: NCIt + cde_id: C99663 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99663" + term_id: C99663 + term_version: 20.10d + +racemetyrosinemethoxsalenphenytoinsirolimus_sm88: + common: + description: >- + A combination agent containing racemetyrosine, methoxsalen, phenytoin and sirolimus, + with potential antineoplastic activity. Upon administration of racemetyrosine/methoxsalen/phenytoin/sirolimus + SM-88, racemetyrosine, being a dysfunctional and modified form of the non-essential + amino acid tyrosine, is specifically taken up by cancer cells through the transporter + L-amino acid transferase-1 (LAT1; CD98). As a tyrosine derivative and faulty + amino acid protein building block, racemetyrosine prevents protein synthesis + in cancer cells. Specifically, this prevents mucin-1 (MUC1) protein synthesis. + MUC1 is highly overexpressed by most cancer cells and regulates the increased + reactive oxygen species (ROS) in cancer cells created from the altered metabolism + that cancer cells utilize, by upregulating key antioxidant defenses and preventing + ROS-mediated apoptosis. In the absence of MUC1, ROS levels are increased, leading + to an increase in oxidative stress, and induction of apoptosis. Also, being + a protective transmembrane protein, MUC1 is part of the protective layer on + the outside of cancer cells and plays a key role in shielding the cancer cell + from the immune system. The loss of MUC1 compromises the cell membrane, thereby + making the cancer cell more vulnerable to be recognized and attacked by the + immune system. Rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, + increases the cancer cells' need for tyrosine uptake and increases the uptake + of racemetyrosine by LAT1. Phenytoin stimulates the release of reactive lipid + species by the liver which accumulate in the tumor microenvironment (TME) and + are taken up by cancer cells, thereby further increasing ROS within the cancer + cell and increasing oxidative-related apoptosis. Mehoxsalen promotes toxic electron + transfer and increases melanin, increases oxidative reactions and production + of ROS. This further stimulates oxidative stress-mediated apoptosis. Normal + cells do not regularly take up certain non-essential amino acids, such as tyrosine, + but readily convert phenylalanine to tyrosine, so normal healthy cells are not + expected to consume racemetyrosine. + termDef: + term: >- + Racemetyrosine/Methoxsalen/Phenytoin/Sirolimus SM-88 + source: NCIt + cde_id: C124051 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124051" + term_id: C124051 + term_version: 20.10d + +racemose_hemangioma: + common: + description: >- + A benign vascular lesion characterized by the presence of a complex network + of communicating arterial and venous vascular structures. + termDef: + term: >- + Arteriovenous Hemangioma/Malformation + source: NCIt + cde_id: C2882 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2882" + term_id: C2882 + term_version: 20.05a + +rad21: + common: + description: >- + This gene is involved in chromosomal cohesion, DNA repair and apoptosis. + termDef: + term: >- + RAD21 Gene + source: NCIt + cde_id: C93082 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93082" + term_id: C93082 + term_version: 20.10d + +rad51b: + common: + description: >- + This gene plays a role in the mediation of homologous recombinational repair + of DNA. + termDef: + term: >- + RAD51B Gene + source: NCIt + cde_id: C90145 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C90145" + term_id: C90145 + term_version: 20.10d + +radgocitabine: + common: + description: >- + An analogue of the nucleoside deoxycytidine with potential antineoplastic activity. + Upon administration, radgocitabine is incorporated into DNA and directly inhibits + the activity of DNA polymerase, which may result in inhibition of DNA replication + and cell cycle arrest in the S and G2/M phases, DNA fragmentation, and tumor + cell apoptosis. + termDef: + term: >- + Radgocitabine + source: NCIt + cde_id: C82697 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82697" + term_id: C82697 + term_version: 20.10d + +radgocitabine_hydrochloride: + common: + description: >- + The hydrochloride salt form of radgocitabine, an analogue of the nucleoside + deoxycytidine with potential antineoplastic activity. Upon administration, radgocitabine + is incorporated into DNA and directly inhibits the activity of DNA polymerase, + which may result in inhibition of DNA replication and cell cycle arrest in the + S and G2/M phases, DNA fragmentation, and tumor cell apoptosis. + termDef: + term: >- + Radgocitabine Hydrochloride + source: NCIt + cde_id: C150430 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150430" + term_id: C150430 + term_version: 20.10d + +radiation_hypofractionated: + common: + description: >- + Radiation treatment in which the total dose of radiation is divided into large + doses and treatments are given less than once a day. + termDef: + term: >- + Hypofractionated Radiation Therapy + source: NCIt + cde_id: C62726 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62726" + term_id: C62726 + term_version: 20.10d + +radiation_photon_beam: + common: + description: >- + Radiation therapy using photon beam. + termDef: + term: >- + Photon Beam Radiation Therapy + source: NCIt + cde_id: C104914 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104914" + term_id: C104914 + term_version: 20.10d + +raeb: + common: + description: >- + A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts + in the bone marrow or 2-19% blasts in the peripheral blood. It includes two + categories: myelodysplastic syndrome with excess blasts-1 and myelodysplastic + syndrome with excess blasts-2. + termDef: + term: >- + Myelodysplastic Syndrome with Excess Blasts + source: NCIt + cde_id: C7506 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7506" + term_id: C7506 + term_version: 20.05a + +raeb_i: + common: + description: >- + A myelodysplastic syndrome defined by 5-9% blasts in the bone marrow, and <5% + blasts in the blood. Approximately 25% of cases progress to an acute leukemia. + (WHO) + termDef: + term: >- + Myelodysplastic Syndrome with Excess Blasts-1 + source: NCIt + cde_id: C7167 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7167" + term_id: C7167 + term_version: 20.05a + +raeb_ii: + common: + description: >- + A myelodysplastic syndrome defined by 10-19% blasts in the bone marrow or 5-19% + blasts in the blood. Approximately 33% of cases progress to acute leukemia. The + prognosis is usually poor. + termDef: + term: >- + Myelodysplastic Syndrome with Excess Blasts-2 + source: NCIt + cde_id: C7168 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7168" + term_id: C7168 + term_version: 20.05a + +raebt: + common: + description: >- + Refractory anemia with excess blasts in transformation (RAEB-T) is characterised + by dysplastic features of the myeloid and usually erythroid progenitor cells + in the bone marrow and an increased number of myeloblasts in the peripheral + blood. The peripheral blood blast count ranges from 20% to 30%. RAEB-T used + to be a subcategory of myelodysplastic syndromes in the past. Recently, the + term has been eliminated from the WHO based classification of myelodysplastic + syndromes. The reason is that the percentage of peripheral blood blasts required + for the diagnosis of acute myeloid leukemia has been reduced to 20%. The elimination + of the RAEB-T term by the WHO experts has created confusion and ongoing arguments. Currently, + according to WHO classification, the vast majority of RAEB-T cases are best + classified as acute leukemias (acute leukemias with multilineage dysplasia following + myelodysplastic syndrome). A minority of cases are part of RAEB-2. + termDef: + term: >- + Refractory Anemia with Excess Blasts in Transformation + source: NCIt + cde_id: C27080 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27080" + term_id: C27080 + term_version: 20.05a + +raf1: + common: + description: >- + This gene is involved in cell growth, proliferation, differentiation and migration. + It also plays a role in apoptosis. + termDef: + term: >- + RAF1 Gene + source: NCIt + cde_id: C18338 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18338" + term_id: C18338 + term_version: 20.10d + +ragifilimab: + common: + description: >- + An anti-human glucocorticoid-induced tumor necrosis factor receptor (tumor necrosis + factor superfamily, member 18; TNFRSF18; GITR; CD357) agonistic humanized monoclonal + antibody, with potential immune checkpoint modulating activity. Ragifilimab + binds to and activates GITRs found on multiple types of T-cells. This stimulates + the immune system, induces both the activation and proliferation of tumor-antigen-specific + T effector cells (Teff), and suppresses the function of activated T regulatory + cells (Tregs). This leads to tumor cell eradication. GITR, a member of the TNF + receptor superfamily and T-cell receptor co-stimulator, is expressed on the + surface of multiple immune cell types, including Tregs, Teffs, B-cells, and + natural killer (NK) cells. Inappropriately activated Tregs suppress Teffs and + suppress T-cell receptor (TCR) signaling. + termDef: + term: >- + Ragifilimab + source: NCIt + cde_id: C126643 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126643" + term_id: C126643 + term_version: 20.10d + +ralgds: + common: + description: >- + This gene plays a role in signal transduction and cytoskeletal remodeling. It + is also involved in regulation of cell growth. + termDef: + term: >- + RALGDS Gene + source: NCIt + cde_id: C24721 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24721" + term_id: C24721 + term_version: 20.10d + +ranbp2: + common: + description: >- + This gene is involved in both SUMOylation and nuclear transport. + termDef: + term: >- + RANBP2 Gene + source: NCIt + cde_id: C114452 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C114452" + term_id: C114452 + term_version: 20.10d + +rap1gds1: + common: + description: >- + This gene is involved in guanine nucleotide exchange. + termDef: + term: >- + RAP1GDS1 Gene + source: NCIt + cde_id: C97758 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97758" + term_id: C97758 + term_version: 20.10d + +rara: + common: + description: >- + This gene plays a role in transcription and retinoic acid receptor signal transduction. + termDef: + term: >- + RARA Gene + source: NCIt + cde_id: C21571 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21571" + term_id: C21571 + term_version: 20.10d + +rars: + common: + description: >- + A myelodysplastic syndrome characterized by an anemia in which 15% or more of + the erythroid precursors are ring sideroblasts. The ring sideroblast is an + erythroid precursor in which one third or more of the nucleus is encircled by + granules which are positive for iron stain. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Ring Sideroblasts + source: NCIt + cde_id: C4036 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4036" + term_id: C4036 + term_version: 20.05a + +rathke_pouch_tumor: + common: + description: >- + A benign, partly cystic, epithelial tumor of the sellar region, presumably derived + from Rathke pouch epithelium. It affects mainly children and young adults. There + are two clinicopathological forms: adamantinomatous craniopharyngioma and papillary + craniopharyngioma. The most significant factor associated with recurrence is + the extent of surgical resection, with lesions greater than 5 cm in diameter + carrying a markedly worse prognosis. (Adapted from WHO) + termDef: + term: >- + Craniopharyngioma + source: NCIt + cde_id: C2964 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2964" + term_id: C2964 + term_version: 20.05a + +rb1: + common: + description: >- + This gene is involved in the regulation of cell differentiation, growth and + proliferation. + termDef: + term: >- + RB1 Gene + source: NCIt + cde_id: C17360 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17360" + term_id: C17360 + term_version: 20.10d + +rbm10: + common: + description: >- + This gene is involved in RNA binding and processing. + termDef: + term: >- + RBM10 Gene + source: NCIt + cde_id: C115382 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C115382" + term_id: C115382 + term_version: 20.10d + +rbm15: + common: + description: >- + This gene plays a role in RNA binding. + termDef: + term: >- + RBM15 Gene + source: NCIt + cde_id: C97293 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97293" + term_id: C97293 + term_version: 20.10d + +rdresponsive_disease: + common: + description: >- + An indication that a patient's disease is responding to treatment. + termDef: + term: >- + Responsive Disease + source: NCIt + cde_id: C165206 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165206" + term_id: C165206 + term_version: 20.05a + +rearrangement: + common: + description: >- + Any change in the structure of one or more chromosomes. + termDef: + term: >- + Chromosomal Rearrangement + source: NCIt + cde_id: C36541 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36541" + term_id: C36541 + term_version: 20.10d + +recklinghausen_disease: + common: + description: >- + The most common type of neurofibromatosis. It is characterized clinically by + cutaneous and subcutaneous tumors with patches of hyperpigmentation. The hyperpigmented + skin areas, are present from birth and found anywhere on the body surface. They + can vary markedly in size and color. The dark brown areas are called cafe-au-lait + spots. The multiple cutaneous and subcutaneous tumors are nerve sheath tumors, + called neurofibromas. They can develop anywhere along the peripheral nerve + fibers. Neurofibromas can become quite large, causing a major disfigurement, + eroding bone, and compressing various peripheral nerve structures. Type 1 neurofibromatosis + has dominant inheritance, with a gene locus on the proximal long arm of chromosome + 17. + termDef: + term: >- + Neurofibromatosis Type 1 + source: NCIt + cde_id: C3273 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3273" + term_id: C3273 + term_version: 20.05a + +recombinant_bacterial_minicells_vax014: + common: + description: >- + A population of recombinant bacterial minicells (rBMCs) engineered to express + the alpha3beta1 (a3b1) and alpha5beta1 (a5b1) integrin-targeting invasion and + that contain a bacterial protein toxin, perfringolysin O (PFO), with potential + antineoplastic activity. Upon intravesical administration, VAX014 selectively + targets and binds to tumor cells expressing un-ligated a3b1 and/or a5b1 integrins + and delivers PFO, leading to destabilization of tumor cell membranes and tumor + cell lysis. By targeting un-ligated a3b1 and/or a5b1 integrins, VAX014 selectively + targets tumor cells over normal cells, with potentially less adverse effects + in comparison with first generation integrin-targeted therapies. + termDef: + term: >- + Recombinant Bacterial Minicells VAX014 + source: NCIt + cde_id: C170742 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170742" + term_id: C170742 + term_version: 20.10d + +recombinant_erwinia_asparaginase_jzp458: + common: + description: >- + A recombinant form of asparaginase (Erwinia asparaginase; crisantaspase) derived + from the bacterium Erwinia chrysanthemi, genetically engineered to be produced + in Pseudomonas fluorescens, with potential antineoplastic activity. Upon administration + of recombinant Erwinia asparaginase JZP-458, the recombinant asparaginase hydrolyzes + L-asparagine to L-aspartic acid and ammonia. This depletes cancer cells of asparagine, + which blocks protein synthesis and tumor cell proliferation. Asparagine is critical + to protein synthesis in cancer cells, which cannot synthesize this amino acid + due to the absence of the enzyme asparagine synthase. JZP-458 can be used as + an alternative in patients who are hypersensitive to Escherichia (E.) coli-derived + asparaginase products. + termDef: + term: >- + Recombinant Erwinia asparaginase JZP-458 + source: NCIt + cde_id: C167120 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167120" + term_id: C167120 + term_version: 20.10d + +recombinant_human_papillomavirus_11valent_vaccine: + common: + description: >- + A recombinant, 11-valent, human papillomavirus (HPV) vaccine, produced in Hansenula + polymorpha, with potential immunoprotective and antineoplastic properties. Upon + administration, recombinant HPV 11-valent vaccine may generate humoral and cellular + immunity against the 11 undisclosed types of HPV antigens, thereby preventing + cervical infection upon exposure to these 11 types of HPV. In addition, this + agent may stimulate an antitumoral cellular immune response against cervical + cancer associated with HPV infection. + termDef: + term: >- + Recombinant Human Papillomavirus 11-valent Vaccine + source: NCIt + cde_id: C168605 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168605" + term_id: C168605 + term_version: 20.10d + +recombinant_human_trailtrimer_fusion_protein_scb313: + common: + description: >- + A recombinant fusion protein composed of the human C-propeptide of alpha1(I) + collagen (Trimer-Tag) to the C-terminus of the mature human tumor necrosis factor + (TNF)-related apoptosis-inducing ligand (TRAIL; Apo2L), with potential pro-apoptotic + and antineoplastic activities. The binding of TRAIL to the Trimer-Tag allows + TRAIL to form a stable covalently-linked homotrimer. Upon administration of + recombinant human TRAIL-trimer fusion protein SCB-313, this fusion protein targets, + binds to and trimerizes the TRAIL-receptors, pro-apoptotic death receptors (DRs) + TRAIL-R1 (death receptor 4; DR4) and TRAIL-R2 (death receptor 5; DR5), expressed + on tumor cells, thereby activating caspases and inducing apoptosis in TRAIL-R1/R2-expressing + tumor cells. TRAIL, a homotrimeric type II transmembrane protein and member + of the TNF superfamily of cytokines, plays a key role in the induction of apoptosis + through TRAIL-mediated death receptor pathways. The pro-apoptotic cell surface + receptors TRAIL-R1 and -R2, members of the TNF receptor family, are overexpressed + by a variety of cancer cell types; The induction of receptor trimerization is + needed for the initiation of the apoptotic signaling pathway. The TRAIL-Trimer + retains similar bioactivity and receptor binding kinetics as native TRAIL but + has more favorable pharmacokinetics and antitumor activity than native TRAIL. + termDef: + term: >- + Recombinant Human TRAIL-Trimer Fusion Protein SCB-313 + source: NCIt + cde_id: C170907 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170907" + term_id: C170907 + term_version: 20.10d + +recombinant_humanized_antiher2_bispecific_monoclonal_antibody_mbs301: + common: + description: >- + A glyco-engineered heterodimeric bispecific monoclonal antibody, derived from + trastuzumab and pertuzumab, directed against two distinct epitopes of the extracellular + dimerization (ECD) domain of the tumor-associated antigen (TAA) human tyrosine + kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with + potential immunomodulating and antineoplastic activities. Upon administration, + recombinant humanized anti-HER-2 bispecific monoclonal antibody MBS301 simultaneously + targets and binds to two separate, non-overlapping epitopes of HER-2. This prevents + the activation of HER-2 signaling pathways. Also, by binding to HER-2, MBS301 + induces an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor + cells that overexpress HER-2. This results in tumor cell apoptosis and inhibits + tumor cell proliferation of HER-2-overexpressing tumor cells. HER-2, overexpressed + on a variety of tumor cell types, plays an important role in tumor cell proliferation, + differentiation and survival. + termDef: + term: >- + Recombinant Humanized Anti-HER-2 Bispecific Monoclonal Antibody MBS301 + source: NCIt + cde_id: C171377 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171377" + term_id: C171377 + term_version: 20.10d + +recql4: + common: + description: >- + This gene is involved in the initiation of DNA replication and sister-chromatid + cohesion. + termDef: + term: >- + RECQL4 Gene + source: NCIt + cde_id: C26492 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26492" + term_id: C26492 + term_version: 20.10d + +recreational_fire_smoke: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced when materials (usually wood) are burned for recreational + purposes. + termDef: + term: >- + Recreational Fire Smoke Exposure + source: NCIt + cde_id: C164094 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164094" + term_id: C164094 + term_version: 19.12e + +rectal_cancer: + common: + description: >- + A malignant epithelial neoplasm that arises from the rectum and invades through + the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. + termDef: + term: >- + Rectal Carcinoma + source: NCIt + cde_id: C9382 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9382" + term_id: C9382 + term_version: 19.12e + +rectosigmoid_junction: + common: + description: >- + The area where the sigmoid colon joins the rectum. + termDef: + term: >- + Rectosigmoid Region + source: NCIt + cde_id: C54188 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54188" + term_id: C54188 + term_version: 20.05a + +rectum_nos: + common: + description: >- + The terminal portion of the gastrointestinal tract, extending from the rectosigmoid + junction to the anal canal. + termDef: + term: >- + Rectum + source: NCIt + cde_id: C12390 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12390" + term_id: C12390 + term_version: 20.05a + +recurrence: + common: + description: >- + The reemergence of a neoplasm after a period of remission. + termDef: + term: >- + Recurrent Neoplasm + source: NCIt + cde_id: C4798 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4798" + term_id: C4798 + term_version: 20.05a + +redaporfin: + common: + description: >- + A bacteriochlorin-based photosensitizer, with antineoplastic activity upon photodynamic + therapy (PDT). Following intravenous administration, redaporfin preferentially + accumulates in hyperproliferative tissues, such as tumors. Local application + of laser light at the tumor site results in the absorption of light by this + agent and a photodynamic reaction between LUZ 11 and oxygen. This results in + the production of reactive oxygen species (ROS), which includes singlet oxygen + molecules, the superoxide ion, and other cytotoxic free radicals. The formation + of ROS induces free radical-mediated DNA damage and cell death. + termDef: + term: >- + Redaporfin + source: NCIt + cde_id: C114382 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C114382" + term_id: C114382 + term_version: 20.10d + +refractory_anemia: + common: + description: >- + A myelodysplastic syndrome characterized mainly by dysplasia of the erythroid + series. Refractory anemia is uncommon. It is primarily a disease of older + adults. The median survival exceeds 5 years. (WHO, 2001) + termDef: + term: >- + Refractory Anemia + source: NCIt + cde_id: C2872 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2872" + term_id: C2872 + term_version: 20.05a + +refractory_anemia_with_excess_blasts: + common: + description: >- + A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts + in the bone marrow or 2-19% blasts in the peripheral blood. It includes two + categories: myelodysplastic syndrome with excess blasts-1 and myelodysplastic + syndrome with excess blasts-2. + termDef: + term: >- + Myelodysplastic Syndrome with Excess Blasts + source: NCIt + cde_id: C7506 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7506" + term_id: C7506 + term_version: 20.05a + +refractory_anemia_with_excess_blasts_in_transformation: + common: + description: >- + Refractory anemia with excess blasts in transformation (RAEB-T) is characterised + by dysplastic features of the myeloid and usually erythroid progenitor cells + in the bone marrow and an increased number of myeloblasts in the peripheral + blood. The peripheral blood blast count ranges from 20% to 30%. RAEB-T used + to be a subcategory of myelodysplastic syndromes in the past. Recently, the + term has been eliminated from the WHO based classification of myelodysplastic + syndromes. The reason is that the percentage of peripheral blood blasts required + for the diagnosis of acute myeloid leukemia has been reduced to 20%. The elimination + of the RAEB-T term by the WHO experts has created confusion and ongoing arguments. Currently, + according to WHO classification, the vast majority of RAEB-T cases are best + classified as acute leukemias (acute leukemias with multilineage dysplasia following + myelodysplastic syndrome). A minority of cases are part of RAEB-2. + termDef: + term: >- + Refractory Anemia with Excess Blasts in Transformation + source: NCIt + cde_id: C27080 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27080" + term_id: C27080 + term_version: 20.05a + +refractory_anemia_with_ring_sideroblasts_associated_with_marked_thrombocytosis: + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm with morphologic and clinical + characteristics of refractory anemia with ring sideroblasts, marked thrombocytosis, + and abnormal megakaryocytes. + termDef: + term: >- + Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis + source: NCIt + cde_id: C82616 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82616" + term_id: C82616 + term_version: 20.05a + +refractory_anemia_with_ringed_sideroblasts: + common: + description: >- + A myelodysplastic syndrome characterized by an anemia in which 15% or more of + the erythroid precursors are ring sideroblasts. The ring sideroblast is an + erythroid precursor in which one third or more of the nucleus is encircled by + granules which are positive for iron stain. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Ring Sideroblasts + source: NCIt + cde_id: C4036 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4036" + term_id: C4036 + term_version: 20.05a + +refractory_anemia_with_sideroblasts: + common: + description: >- + A myelodysplastic syndrome characterized by an anemia in which 15% or more of + the erythroid precursors are ring sideroblasts. The ring sideroblast is an + erythroid precursor in which one third or more of the nucleus is encircled by + granules which are positive for iron stain. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Ring Sideroblasts + source: NCIt + cde_id: C4036 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4036" + term_id: C4036 + term_version: 20.05a + +refractory_cytopenia_of_childhood: + common: + description: >- + The most common subtype of the myelodysplastic syndromes affecting children. + It is characterized by persistent cytopenia with less than 5% blasts in the + bone marrow and less than 2% blasts in the peripheral blood. + termDef: + term: >- + Refractory Cytopenia of Childhood + source: NCIt + cde_id: C82596 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82596" + term_id: C82596 + term_version: 20.05a + +refractory_cytopenia_with_multilineage_dysplasia: + common: + description: >- + A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia and + dysplastic changes in 10% or more of the cells in two or more of the myeloid + cell lines. (WHO, 2001) + termDef: + term: >- + Myelodysplastic Syndrome with Multilineage Dysplasia + source: NCIt + cde_id: C8574 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8574" + term_id: C8574 + term_version: 20.05a + +refractory_neutropenia: + common: + description: >- + A myelodysplastic syndrome characterized by the presence of at least 10% dysplastic + neutrophils in the bone marrow or the peripheral blood. + termDef: + term: >- + Refractory Neutropenia + source: NCIt + cde_id: C82593 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82593" + term_id: C82593 + term_version: 20.05a + +refractory_thrombocytopenia: + common: + description: >- + A myelodysplastic syndrome characterized by the presence of at least 10% dysplastic + megakaryocytes, found within at least 30 megakaryocytes examined in the bone + marrow. + termDef: + term: >- + Refractory Thrombocytopenia + source: NCIt + cde_id: C82594 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82594" + term_id: C82594 + term_version: 20.05a + +regional_or_distant_metastasis_m1: + common: + description: >- + Regional or distant metastasis. + termDef: + term: >- + Enneking Metastasis M1 + source: NCIt + cde_id: C147529 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C147529" + term_id: C147529 + term_version: 20.05a + +regressing_nevus: + common: + description: >- + A nevus associated with focal regression-like changes. + termDef: + term: >- + Regressing Nevus + source: NCIt + cde_id: C7603 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7603" + term_id: C7603 + term_version: 20.05a + +regulatory_region_ablation: + common: + description: >- + A deletion mutation where the deleted sequence includes of a regulatory region + for a gene. + termDef: + term: >- + Regulatory Region Deletion + source: NCIt + cde_id: C148647 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148647" + term_id: C148647 + term_version: 20.10d + +regulatory_region_amplification: + common: + description: >- + An increase in the copy number of a region containing a regulatory sequence + for a gene. + termDef: + term: >- + Regulatory Region Amplification + source: NCIt + cde_id: C148648 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148648" + term_id: C148648 + term_version: 20.10d + +regulatory_region_variant: + common: + description: >- + A change in the nucleotide sequence of a regulatory region for a gene. + termDef: + term: >- + Regulatory Region Mutation + source: NCIt + cde_id: C148646 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148646" + term_id: C148646 + term_version: 20.10d + +rel: + common: + description: >- + This gene is involved in transcriptional regulation and signal transduction + through the nuclear factor kappa B NFKB signal transduction pathway. + termDef: + term: >- + REL Gene + source: NCIt + cde_id: C17084 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17084" + term_id: C17084 + term_version: 20.10d + +renal_carcinoma_collecting_duct_type: + common: + description: >- + Also known as collecting duct carcinoma, this is a rare type of renal carcinoma. + It arises from the collecting ducts of the renal medulla, and most authors suggest + that this is an aggressive tumor. + termDef: + term: >- + Collecting Duct Carcinoma + source: NCIt + cde_id: C6194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6194" + term_id: C6194 + term_version: 20.05a + +renal_cell_adenocarcinoma: + common: + description: >- + A carcinoma arising from the renal parenchyma. There is a strong correlation + between cigarette smoking and the development of renal cell carcinoma. The + clinical presentation includes : hematuria, flank pain and a palpable lumbar + mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound + is performed for other purposes. Radical nephrectomy is the standard intervention + procedure. Renal cell carcinoma is generally considered to be resistant to + radiation treatment and chemotherapy. + termDef: + term: >- + Renal Cell Carcinoma + source: NCIt + cde_id: C9385 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9385" + term_id: C9385 + term_version: 20.05a + +renal_cell_carcinoma_chromophobe_type: + common: + description: >- + A type of carcinoma that comprises a minority of renal cell carcinomas. It + is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics + of the neoplastic cells, this type of carcinoma is classified as classic (typical) + or eosinophilic. It has a much better prognosis than other renal cell carcinomas. + termDef: + term: >- + Chromophobe Renal Cell Carcinoma + source: NCIt + cde_id: C4146 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4146" + term_id: C4146 + term_version: 20.05a + +renal_cell_carcinoma_nos: + common: + description: >- + A carcinoma arising from the renal parenchyma. There is a strong correlation + between cigarette smoking and the development of renal cell carcinoma. The + clinical presentation includes : hematuria, flank pain and a palpable lumbar + mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound + is performed for other purposes. Radical nephrectomy is the standard intervention + procedure. Renal cell carcinoma is generally considered to be resistant to + radiation treatment and chemotherapy. + termDef: + term: >- + Renal Cell Carcinoma + source: NCIt + cde_id: C9385 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9385" + term_id: C9385 + term_version: 20.05a + +renal_cell_carcinoma_sarcomatoid: + common: + description: >- + A high grade carcinoma of the kidney. It is not a distinct clinicopathological + entity and includes a diverse group of renal cell carcinomas which have been + transformed from a lower to a higher grade. + termDef: + term: >- + Sarcomatoid Renal Cell Carcinoma + source: NCIt + cde_id: C27893 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27893" + term_id: C27893 + term_version: 20.05a + +renal_cell_carcinoma_spindle_cell: + common: + description: >- + A high grade carcinoma of the kidney. It is not a distinct clinicopathological + entity and includes a diverse group of renal cell carcinomas which have been + transformed from a lower to a higher grade. + termDef: + term: >- + Sarcomatoid Renal Cell Carcinoma + source: NCIt + cde_id: C27893 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27893" + term_id: C27893 + term_version: 20.05a + +renal_cell_carcinoma_unclassified: + common: + description: >- + A carcinoma arising from the renal parenchyma. There is a strong correlation + between cigarette smoking and the development of renal cell carcinoma. The + clinical presentation includes : hematuria, flank pain and a palpable lumbar + mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound + is performed for other purposes. Radical nephrectomy is the standard intervention + procedure. Renal cell carcinoma is generally considered to be resistant to + radiation treatment and chemotherapy. + termDef: + term: >- + Renal Cell Carcinoma + source: NCIt + cde_id: C9385 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9385" + term_id: C9385 + term_version: 20.05a + +renal_disorder_nos: + common: + description: >- + A neoplastic or non-neoplastic condition affecting the kidney. Representative + examples of non-neoplastic conditions include glomerulonephritis and nephrotic + syndrome. Representative examples of neoplastic conditions include benign processes + (e.g., renal lipoma and renal fibroma) and malignant processes (e.g., renal + cell carcinoma and renal lymphoma). + termDef: + term: >- + Kidney Disorder + source: NCIt + cde_id: C3149 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3149" + term_id: C3149 + term_version: 19.12e + +renal_medullary_carcinoma: + common: + description: >- + A type of renal carcinoma affecting mostly young African-Americans. It is located + in the medulla of the kidney, and follows an aggressive clinical course. Most + reported cases have shown metastatic disease at the time of diagnosis. + termDef: + term: >- + Kidney Medullary Carcinoma + source: NCIt + cde_id: C7572 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7572" + term_id: C7572 + term_version: 20.05a + +renal_pelvis: + common: + description: >- + The funnel-shaped proximal portion of the ureter located within the kidney into + which urine is secreted, from the collecting duct system of the kidney. + termDef: + term: >- + Renal Pelvis + source: NCIt + cde_id: C12887 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12887" + term_id: C12887 + term_version: 20.05a + +reninoma: + common: + description: >- + A benign, well circumscribed neoplasm arising from the cortex of the kidney. + It secrets renin and the patients usually present with severe hypertension and + marked hypokalemia. Morphologically, it is characterized by the presence of + sheets of polygonal or spindle-shaped neoplastic cells forming a hemangiopericytic + pattern. + termDef: + term: >- + Juxtaglomerular Cell Tumor + source: NCIt + cde_id: C4162 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4162" + term_id: C4162 + term_version: 20.05a + +repeated_sequences: + common: + description: >- + Nucleotide sequences present in multiple copies in the genome. There are several + types of repeated sequences. Interspersed (or dispersed) DNA repeats (Interspersed + Repetitive Sequences) are copies of transposable elements interspersed throughout + the genome. Flanking (or terminal) repeats (Terminal Repeat Sequences) are sequences + that are repeated on both ends of a sequence, for example, the long terminal + repeats (LTRs) on retroviruses. Direct terminal repeats are in the same direction + and inverted terminal repeats are opposite to each other in direction. Tandem + repeats (Tandem Repeat Sequences) are repeated copies which lie adjacent to + each other. These can also be direct or inverted. The ribosomal RNA and transfer + RNA genes belong to the class of middle repetitive DNA. + termDef: + term: >- + Repetitive Sequence + source: NCIt + cde_id: C13298 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13298" + term_id: C13298 + term_version: 20.10d + +reserve_cell_carcinoma: + common: + description: >- + A neuroendocrine carcinoma composed of small malignant cells which are often + said to resemble "oat cells" under the microscope. Small cell carcinoma most + often affects the lungs. Clinically, this is often a rapidly growing cancer + that spreads to distant sites early. + termDef: + term: >- + Small Cell Carcinoma + source: NCIt + cde_id: C3915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3915" + term_id: C3915 + term_version: 20.05a + +ret: + common: + description: >- + This gene plays an essential role in neural crest development, cellular growth + and differentiation. Mutations in the gene are associated with a variety of + neoplasias and carcinomas + termDef: + term: >- + RET Gene + source: NCIt + cde_id: C18257 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18257" + term_id: C18257 + term_version: 20.10d + +reticuloendothelial_system_nos: + common: + description: >- + A widely distributed collection of both free and fixed macrophages derived from + bone marrow precursor cells by way of monocytes; their substantial phagocytic + activity is mediated by immunoglobulin and the serum complement system. In both + connective and lymphoid tissue, they may occur as free and fixed macrophages; + in the sinusoids of the liver, as Kupffer cells; in the lung, as alveolar macrophages; + and in the nervous system, as microglia. + termDef: + term: >- + Reticuloendothelial System + source: NCIt + cde_id: C12780 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12780" + term_id: C12780 + term_version: 20.05a + +reticulohistiocytoma: + common: + description: >- + A rare cutaneous lesion composed of eosinophilic histiocytes, which are often + multinucleated. The lesions are yellow-brown papules affecting any part of + the body. Patients are usually adult men. The prognosis is excellent. -- 2003 + termDef: + term: >- + Solitary Reticulohistiocytoma + source: NCIt + cde_id: C3356 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3356" + term_id: C3356 + term_version: 20.05a + +reticulosarcoma_nos: + common: + description: >- + An antiquated term that refers to a non-Hodgkin lymphoma composed of diffuse + infiltrates of large, often anaplastic lymphocytes. + termDef: + term: >- + Reticulosarcoma + source: NCIt + cde_id: C27824 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27824" + term_id: C27824 + term_version: 20.05a + +reticulum_cell_sarcoma_nos: + common: + description: >- + An antiquated term that refers to a non-Hodgkin lymphoma composed of diffuse + infiltrates of large, often anaplastic lymphocytes. + termDef: + term: >- + Reticulosarcoma + source: NCIt + cde_id: C27824 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27824" + term_id: C27824 + term_version: 20.05a + +retifanlimab: + common: + description: >- + A proprietary humanized monoclonal antibody directed against the negative immunoregulatory + human cell surface receptor programmed cell death 1 (PD-1), with potential immune + checkpoint inhibitory and antineoplastic activities. Upon administration, retifanlimab + binds to and inhibits PD-1 and its downstream signaling pathways. This may restore + immune function through the activation of T-cells and cell-mediated immune responses + against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily + (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively + regulates T-cell activation and effector function when activated by its ligands + programmed cell death ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role + in tumor evasion from host immunity. + termDef: + term: >- + Retifanlimab + source: NCIt + cde_id: C142168 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142168" + term_id: C142168 + term_version: 20.10d + +retina: + common: + description: >- + A light-sensitive membrane that lines the back wall of the eyeball. The retina + is continuous with the optic nerve and this way transmits optical images to + the brain. + termDef: + term: >- + Retina + source: NCIt + cde_id: C12343 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12343" + term_id: C12343 + term_version: 20.05a + +retinal_anlage_tumor: + common: + description: >- + A rare neoplasm usually occurring in infants. It is characterized by the presence + of a mixture of melanin-containing epithelial cells and smaller neuroblast-like + cells. It may involve the skull and facial bones, or the epididymis. It usually + has a benign clinical course. + termDef: + term: >- + Melanotic Neuroectodermal Tumor + source: NCIt + cde_id: C3717 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3717" + term_id: C3717 + term_version: 20.05a + +retinoblastoma_differentiated: + common: + description: >- + A retinoblastoma with well differentiated features. It often produces Flexner-Wintersteiner + rosettes or Homer-Wright rosettes. In some cases the tumor cells form fleurettes. + termDef: + term: >- + Differentiated Retinoblastoma + source: NCIt + cde_id: C66813 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66813" + term_id: C66813 + term_version: 20.05a + +retinoblastoma_diffuse: + common: + description: >- + A retinoblastoma characterized by the absence of a distinct retinal mass and + the presence of malignant cells diffusely infiltrating the retina. It is often + confused with uveitis and endophthalmitis, resulting in delayed diagnosis of + the malignancy. + termDef: + term: >- + Diffuse Retinoblastoma + source: NCIt + cde_id: C66815 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66815" + term_id: C66815 + term_version: 20.05a + +retinoblastoma_nos: + common: + description: >- + A malignant tumor that originates in the nuclear layer of the retina. As the + most common primary tumor of the eye in children, retinoblastoma is still relatively + uncommon, accounting for only 1% of all malignant tumors in pediatric patients. + Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, + bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas + are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has + been associated with 13q14 cytogenetic abnormalities. Patients with the inherited + form also appear to be at increased risk for secondary nonocular malignancies + such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. + termDef: + term: >- + Retinoblastoma + source: NCIt + cde_id: C7541 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7541" + term_id: C7541 + term_version: 20.05a + +retinoblastoma_spontaneously_regressed: + common: + description: >- + This term applies to a retinoblastoma which has regressed spontaneously. Histologic + examination of the tumor reveals benign-appearing tumor cells, with no evidence + of nuclear atypia, pleomorphism, or rosettes formation. There is a well-vascularized + stroma which contains calcifications. + termDef: + term: >- + Spontaneously Regressing Retinoblastoma + source: NCIt + cde_id: C66816 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66816" + term_id: C66816 + term_version: 20.05a + +retinoblastoma_undifferentiated: + common: + description: >- + A retinoblastoma composed of small, undifferentiated cells. It is often associated + with necrotic changes. + termDef: + term: >- + Undifferentiated Retinoblastoma + source: NCIt + cde_id: C66814 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66814" + term_id: C66814 + term_version: 20.05a + +retinocytoma: + common: + description: >- + A rare, unilateral or bilateral benign retinal neoplasm. Since there is a risk + of malignant transformation to retinoblastoma, patients should be closely observed. + termDef: + term: >- + Retinocytoma + source: NCIt + cde_id: C66812 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66812" + term_id: C66812 + term_version: 20.05a + +retromolar_area: + common: + description: >- + A triangular-shaped area of mucosa located posterior the last mandibular molar + tooth. + termDef: + term: >- + Retromolar Trigone + source: NCIt + cde_id: C54223 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54223" + term_id: C54223 + term_version: 20.05a + +retroperitoneal: + common: + description: >- + A lymph node located in the retroperitoneal space. + termDef: + term: >- + Retroperitoneal Lymph Node + source: NCIt + cde_id: C98189 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98189" + term_id: C98189 + term_version: 20.10d + +retroperitoneal_fibromatosis: + common: + description: >- + An insidious poorly circumscribed neoplasm arising from the deep soft tissues + of the abdomen. It is characterized by the presence of elongated spindle-shaped + fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. + termDef: + term: >- + Abdominal (Mesenteric) Fibromatosis + source: NCIt + cde_id: C3741 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3741" + term_id: C3741 + term_version: 20.05a + +retroperitoneum: + common: + description: >- + The back of the abdomen where the kidneys lie and the great blood vessels run. + termDef: + term: >- + Retroperitoneum + source: NCIt + cde_id: C12298 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12298" + term_id: C12298 + term_version: 20.05a + +retsrc_inhibitor_tpx0046: + common: + description: >- + An orally bioavailable selective dual inhibitor of fusions and mutations involving + the proto-oncogene receptor tyrosine kinase rearranged during transfection (ret) + and the src family tyrosine kinases, with potential antineoplastic activity. + Upon oral administration, the RET/SRC inhibitor TPX-0046 specifically targets + and binds to ret mutants and ret-containing fusion products. This results in + an inhibition of cell growth of tumor cells that exhibit increased ret activity. + By inhibiting src kinase-mediated signaling and reducing the src-initiated recruitment + of multiple receptor tyrosine kinases involved in bypass resistance, TPX-0046 + may be able to overcome tumor resistance which may increase its therapeutic + effect. Ret overexpression, activating mutations, and fusions result in the + upregulation and/or overactivation of ret tyrosine kinase activity in various + cancer cell types; dysregulation of ret activity plays a key role in the development + and progression of these cancers. Src tyrosine kinases are upregulated in many + tumor cells and play important roles in tumor cell proliferation, survival, + migration, invasion and angiogenesis. Src upregulation is seen in tumors with + acquired resistance to RET inhibitors. + termDef: + term: >- + RET/SRC Inhibitor TPX-0046 + source: NCIt + cde_id: C167210 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167210" + term_id: C167210 + term_version: 20.10d + +reunion: + common: + description: >- + A country in southern Africa, occupying an island in the Indian Ocean, east + of Madagascar and west of Mauritius. + termDef: + term: >- + Reunion + source: NCIt + cde_id: C17095 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17095" + term_id: C17095 + term_version: 19.12e + +revdofilimab: + common: + description: >- + An agonistic humanized IgG1 monoclonal antibody that recognizes the co-stimulatory + receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), + with potential immunostimulatory activity. Upon administration, revdofilimab + selectively binds to and activates OX40. This may induce the proliferation of + memory and effector T-lymphocytes and inhibit the function of T-regulatory cells + (Tregs) in the tumor microenvironment (TME). OX40, a cell surface glycoprotein + and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed + on T-lymphocytes and plays an essential role in T-cell activation and differentiation. + termDef: + term: >- + Revdofilimab + source: NCIt + cde_id: C161864 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C161864" + term_id: C161864 + term_version: 20.10d + +rezivertinib: + common: + description: >- + An orally available third-generation and selective inhibitor of certain epidermal + growth factor receptor (EGFR) activating mutations, including the resistance + mutations T790M and L858R, as well as exon 19 deletion, with potential antineoplastic + activity. Upon administration, rezivertinib specifically and covalently binds + to and inhibits selective EGFR mutations, with particularly high selectivity + against the T790M mutation, which prevents EGFR mutant-mediated signaling and + leads to cell death in EGFR mutant-expressing tumor cells. Compared to some + other EGFR inhibitors, BPI-7711 may have therapeutic benefits in tumors with + T790M-mediated drug resistance. This agent shows minimal activity against wild-type + EGFR (wt EGFR), and does not cause dose-limiting toxicities that occur during + the use of non-selective EGFR inhibitors, which also inhibit wt EGFR. EGFR, + a receptor tyrosine kinase mutated in many tumor cell types, plays a key role + in tumor cell proliferation and tumor vascularization. + termDef: + term: >- + Rezivertinib + source: NCIt + cde_id: C154286 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154286" + term_id: C154286 + term_version: 20.10d + +rgpd3: + common: + description: >- + This gene may play a role in the localization of the GTPase Ran. + termDef: + term: >- + RGPD3 Gene + source: NCIt + cde_id: C143082 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143082" + term_id: C143082 + term_version: 20.10d + +rgs7: + common: + description: >- + This gene plays a role in the inhibition of both G protein-coupled receptor + signaling and signal transduction. + termDef: + term: >- + RGS7 Gene + source: NCIt + cde_id: C143118 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143118" + term_id: C143118 + term_version: 20.10d + +rhabdoid_meningioma: + common: + description: >- + A WHO grade III meningioma characterized by the predominant presence of rhabdoid + cells forming sheets. + termDef: + term: >- + Rhabdoid Meningioma + source: NCIt + cde_id: C6909 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6909" + term_id: C6909 + term_version: 20.05a + +rhabdoid_sarcoma: + common: + description: >- + An aggressive malignant embryonal neoplasm usually occurring during childhood. It + is characterized by the presence of large cells with abundant cytoplasm, large + eccentric nucleus, and a prominent nucleolus and it is associated with abnormalities + of chromosome 22. It can arise from the central nervous system, kidney, and + the soft tissues. The prognosis is poor. + termDef: + term: >- + Rhabdoid Tumor + source: NCIt + cde_id: C3808 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3808" + term_id: C3808 + term_version: 20.05a + +rhabdoid_tumor_nos: + common: + description: >- + An aggressive malignant embryonal neoplasm usually occurring during childhood. It + is characterized by the presence of large cells with abundant cytoplasm, large + eccentric nucleus, and a prominent nucleolus and it is associated with abnormalities + of chromosome 22. It can arise from the central nervous system, kidney, and + the soft tissues. The prognosis is poor. + termDef: + term: >- + Rhabdoid Tumor + source: NCIt + cde_id: C3808 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3808" + term_id: C3808 + term_version: 20.05a + +rhabdomyoma_nos: + common: + description: >- + A benign mesenchymal tumor arising from skeletal or cardiac muscle. + termDef: + term: >- + Rhabdomyoma + source: NCIt + cde_id: C3358 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3358" + term_id: C3358 + term_version: 20.05a + +rhabdomyosarcoma: + common: + description: >- + A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. + It usually occurs in children and young adults. Only a small percentage of tumors + arise in the skeletal muscle of the extremities. The majority arise in other + anatomical sites. + termDef: + term: >- + Rhabdomyosarcoma + source: NCIt + cde_id: C3359 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3359" + term_id: C3359 + term_version: 19.12e + +rhabdomyosarcoma_nos: + common: + description: >- + A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. + It usually occurs in children and young adults. Only a small percentage of tumors + arise in the skeletal muscle of the extremities. The majority arise in other + anatomic sites. + termDef: + term: >- + Rhabdomyosarcoma + source: NCIt + cde_id: C3359 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3359" + term_id: C3359 + term_version: 20.05a + +rhabdomyosarcoma_with_ganglionic_differentiation: + common: + description: >- + An aggressive malignant mesenchymal neoplasm of the nervous system or soft tissues. + It is characterized by the presence of a sarcomatous component (most often rhabdomyosarcoma) + and a ganglionic or a neuroectodermal component. + termDef: + term: >- + Ectomesenchymoma + source: NCIt + cde_id: C4716 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4716" + term_id: C4716 + term_version: 20.05a + +rhabdosarcoma: + common: + description: >- + A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. + It usually occurs in children and young adults. Only a small percentage of tumors + arise in the skeletal muscle of the extremities. The majority arise in other + anatomic sites. + termDef: + term: >- + Rhabdomyosarcoma + source: NCIt + cde_id: C3359 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3359" + term_id: C3359 + term_version: 20.05a + +rhoa: + common: + description: >- + This gene plays a role in signal transduction. It is involved in several cellular + functions including cell differentiation and cytoskeletal remodeling. + termDef: + term: >- + RHOA Gene + source: NCIt + cde_id: C18356 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18356" + term_id: C18356 + term_version: 20.10d + +rhoh: + common: + description: >- + This gene plays a role in signal transduction in hematopoietic cells. + termDef: + term: >- + RHOH Gene + source: NCIt + cde_id: C21320 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21320" + term_id: C21320 + term_version: 20.10d + +right: + common: + description: >- + Being or located on or directed toward the side of the body to the east when + facing north. + termDef: + term: >- + Right + source: NCIt + cde_id: C25228 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25228" + term_id: C25228 + term_version: 20.05a + +ripertamab: + common: + description: >- + A chimeric monoclonal antibody directed against human CD20, with potential antineoplastic + activity. Ripertamab binds to the B-cell-specific cell surface antigen CD20, + which triggers an immune response against CD20-positive B-cells, leading to + apoptosis. CD20, a non-glycosylated cell surface phosphoprotein, is exclusively + expressed on B-cells during most stages of B-cell development and is often overexpressed + in B-cell malignancies. + termDef: + term: >- + Ripertamab + source: NCIt + cde_id: C122680 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122680" + term_id: C122680 + term_version: 20.10d + +rmi2: + common: + description: >- + This gene is involved in DNA replication. + termDef: + term: >- + RMI2 Gene + source: NCIt + cde_id: C96027 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96027" + term_id: C96027 + term_version: 20.10d + +rna_sequencing: + common: + description: >- + A procedure that can determine the nucleotide sequence for all of the RNA transcripts + in an individual. + termDef: + term: >- + Whole Transcriptome Sequencing + source: NCIt + cde_id: C124261 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124261" + term_id: C124261 + term_version: 20.10d + +rnf213: + common: + description: >- + This gene may be involved in ubiquitination. + termDef: + term: >- + RNF213 Gene + source: NCIt + cde_id: C97390 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97390" + term_id: C97390 + term_version: 20.10d + +rnf43: + common: + description: >- + This gene is involved in both protein ubiquitination and the Wnt signaling pathway. + termDef: + term: >- + RNF43 Gene + source: NCIt + cde_id: C107649 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107649" + term_id: C107649 + term_version: 20.10d + +roblitinib: + common: + description: >- + An inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential + antineoplastic activity. Upon administration, roblitinib binds to and inhibits + the activity of FGFR4, which leads to an inhibition of tumor cell proliferation + in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated + in certain tumor cells and involved in tumor cell proliferation, differentiation, + angiogenesis, and survival. + termDef: + term: >- + Roblitinib + source: NCIt + cde_id: C120102 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C120102" + term_id: C120102 + term_version: 20.10d + +robo1targeted_bicarnkt_cells: + common: + description: >- + A preparation of natural killer T (NKT) cells engineered to express a chimeric + antigen receptor (CAR) specific for roundabout homolog 1 (ROBO1, Robo1), with + potential immunostimulating and antineoplastic activities. Upon administration, + the ROBO1-targeted BiCAR-NK/T cells target and bind to ROBO1 expressed on the + surface of tumor cells. This induces selective toxicity in ROBO1-expressing + tumor cells. ROBO1, a member of the axon guidance receptor family, is often + overexpressed in a variety of tumor types. It is involved in axon guidance, + cell proliferation, cell motility and angiogenesis. + termDef: + term: >- + ROBO1-targeted BiCAR-NKT Cells + source: NCIt + cde_id: C172380 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172380" + term_id: C172380 + term_version: 20.10d + +robo2: + common: + description: >- + This gene plays a role in ligand binding, axon guidance and cell migration. + termDef: + term: >- + ROBO2 Gene + source: NCIt + cde_id: C126774 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126774" + term_id: C126774 + term_version: 20.10d + +rocakinogene_sifuplasmid: + common: + description: >- + A plasmid DNA vaccine encoding the human pro-inflammatory cytokine interleukin-12 + (IL-12) with potential immunoactivating activity. Upon intramuscular delivery + by electroporation of rocakinogene sifuplasmid, IL-12 is translated in cells + and activates the immune system by promoting the activation of natural killer + cells (NK cells), inducing secretion of interferon-gamma and promoting cytotoxic + T-cell responses against tumor cells. This may result in both immune-mediated + tumor cell death and the inhibition of tumor cell proliferation. + termDef: + term: >- + Rocakinogene Sifuplasmid + source: NCIt + cde_id: C116709 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116709" + term_id: C116709 + term_version: 20.10d + +rodent_ulcer: + common: + description: >- + A type of basal cell carcinoma of the skin. It appears as a flesh-colored papule + with telangiectatic vessels on its surface. It grows slowly; as it enlarges + it becomes necrotic forming a central ulcer with raised borders. + termDef: + term: >- + Skin Nodulo-Ulcerative Basal Cell Carcinoma + source: NCIt + cde_id: C5568 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5568" + term_id: C5568 + term_version: 20.05a + +roducitabine: + common: + description: >- + An orally available small molecule and nucleoside antimetabolite with potential + antineoplastic activity. Upon administration, tRoducitabine is taken up by cells + through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase + (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate + forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA + synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) + to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, + RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). This eventually leads + to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting + enzyme in the pyrimidine-nucleotide salvage pathway. + termDef: + term: >- + Roducitabine + source: NCIt + cde_id: C113444 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113444" + term_id: C113444 + term_version: 20.10d + +rolinsatamab_talirine: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a proprietary monoclonal antibody + against the prolactin receptor (PRLR) linked to an as of yet undisclosed cytotoxic + agent, with potential antineoplastic activity. Upon intravenous administration + of rolinsatamab talirine, rolinsatamab targets and binds to PRLR expressed on + tumor cells. Upon binding and internalization, talirine is released and kills + the PRLR-expressing tumor cells, through an as of yet unknown mechanism of action. + PRLR, a tumor-associated antigen (TAA), is overexpressed by a variety of tumor + cell types. + termDef: + term: >- + Rolinsatamab Talirine + source: NCIt + cde_id: C137991 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137991" + term_id: C137991 + term_version: 20.10d + +romania: + common: + description: >- + A country in southeastern Europe, bordering the Black Sea, between Bulgaria + and Ukraine. + termDef: + term: >- + Romania + source: NCIt + cde_id: C17108 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17108" + term_id: C17108 + term_version: 19.12e + +roneparstat: + common: + description: >- + An N-acetylated, glycol-split form of heparin that is devoid of anticoagulant + activity and is an inhibitor of heparanase with antineoplastic and antiangiogenic + activities. Upon subcutaneous administration, roneparstat inhibits the activity + of heparanase. This prevents the heparanase-mediated cleavage of heparan sulfate + (HS) proteoglycans on cell surfaces and within the extracellular matrix. In + addition, this agent prevents the heparanase-induced production of a number + of angiogenic growth factors, including matrix metalloproteinase-9, hepatocyte + growth factor and vascular endothelial growth factor. Altogether, this leads + to an inhibition of both tumor cell growth and angiogenesis. Heparanase, an + enzyme that is responsible for the proteolytic cleavage of proteoglycans, is + upregulated in a variety of tumor cell types and promotes tumor cell growth; + it plays a key role in tumor cell invasion, metastasis and angiogenesis. + termDef: + term: >- + Roneparstat + source: NCIt + cde_id: C104412 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104412" + term_id: C104412 + term_version: 20.10d + +ropeginterferon_alfa2b: + common: + description: >- + A long-acting formulation of recombinant interferon alpha subtype 2b (IFN-a2b), + in which IFN-a2b is coupled, via proline, to polyethylene glycol (PEG), with + antiviral, immunomodulating and antineoplastic activities. Upon administration + of ropeginterferon alfa-2b, IFN-a2b targets and binds to specific IFN cell-surface + receptors. This activates IFN-mediated signal transduction pathways and induces + the transcription and translation of genes with IFN-specific response elements + (ISREs). Their protein products mediate antiviral, antiproliferative, anticancer, + and immune-modulating effects. The PEG moiety inhibits proteolytic breakdown + and clearance of IFN-a2b, which prolongs its half-life, extends the duration + of its therapeutic effects and allows less frequent dosing. The proline linker + facilitates the synthesis of a single positional isomer which further increases + its stability and half-life. + termDef: + term: >- + Ropeginterferon Alfa-2B + source: NCIt + cde_id: C111892 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111892" + term_id: C111892 + term_version: 20.10d + +ropocamptide: + common: + description: >- + A synthetic form of a human antimicrobial peptide (37 amino acids), belonging + to the cathelicidin family, with antimicrobial, anti-inflammatory, immunostimulating + and potential antineoplastic activities. Upon intratumoral injection of the + ropocamptide, this peptide increases p53 expression, and induces phosphatidylserine + externalization, DNA fragmentation, cell cycle arrest and caspase-independent + apoptosis-inducing factor (AIF)/ endonuclease G (EndoG)-mediated apoptotic cell + death in susceptible cancer cells. This suppresses tumor cell proliferation. LL-37, + a protein secreted by bone marrow cells, circulating leukocytes, and various + epithelial tissues, plays a crucial role in the innate host immune defense via + the regulation of leukocyte chemotaxis and cytokine production; it also promotes + wound healing. + termDef: + term: >- + Ropocamptide + source: NCIt + cde_id: C118292 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C118292" + term_id: C118292 + term_version: 20.10d + +ros1: + common: + description: >- + This gene plays a role in receptor tyrosine phosphorylation signal transduction, + and is thought to play a role in cellular growth or differentiation, but an + exact function has not been substantiated. + termDef: + term: >- + ROS1 Gene + source: NCIt + cde_id: C18399 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18399" + term_id: C18399 + term_version: 20.10d + +rosetteforming_glioneuronal_tumor: + common: + description: >- + A central nervous system neoplasm mostly occurring in the fourth ventricle region. + It is characterized by the presence of neurocytes forming pseudorosettes and + astrocytes which contain Rosenthal fibers. Cytologic atypia is minimal. + termDef: + term: >- + Rosette-Forming Glioneuronal Tumor + source: NCIt + cde_id: C129431 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129431" + term_id: C129431 + term_version: 20.05a + +rosopatamab: + common: + description: >- + A humanized monoclonal antibody (MoAb) against the external domain of the Prostate-specific + membrane antigen (PSMA), overexpressed in the malignant prostate and its metastases. + Although PSMA is not a biomarker of disease progression, over-expression indicates + an aggressive phenotype of the prostate cancer. Rosopatamab was generated by + replacing murine Ig sequences with human ones, thereby MoAb huJ591can be administered + to patients on multiple occasions over long time periods without inducing an + immune response. Radiolabelled MoAb huJ591 may be used in immunotherapy of prostate + cancer. + termDef: + term: >- + Rosopatamab + source: NCIt + cde_id: C2652 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2652" + term_id: C2652 + term_version: 20.10d + +round_cell_carcinoma: + common: + description: >- + A neuroendocrine carcinoma composed of small malignant cells which are often + said to resemble "oat cells" under the microscope. Small cell carcinoma most + often affects the lungs. Clinically, this is often a rapidly growing cancer + that spreads to distant sites early. + termDef: + term: >- + Small Cell Carcinoma + source: NCIt + cde_id: C3915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3915" + term_id: C3915 + term_version: 20.05a + +round_cell_liposarcoma: + common: + description: >- + A poorly differentiated liposarcoma, characterized by the presence of solid + sheets of primitive round mesenchymal cells and the absence of myxoid stroma. + termDef: + term: >- + Round Cell Liposarcoma + source: NCIt + cde_id: C4252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4252" + term_id: C4252 + term_version: 20.05a + +round_cell_osteosarcoma: + common: + description: >- + An osteosarcoma usually arising from the metaphysis of long bones. It is characterized + by the presence of small cells and osteoid production. The prognosis is usually + unfavorable. + termDef: + term: >- + Small Cell Osteosarcoma + source: NCIt + cde_id: C4023 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4023" + term_id: C4023 + term_version: 20.05a + +round_ligament: + common: + description: >- + Any of the round ligaments including the round ligament of the liver and the + round ligament of the uterus. + termDef: + term: >- + Round Ligament + source: NCIt + cde_id: C12319 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12319" + term_id: C12319 + term_version: 20.05a + +rpdradiographic_progressive_disease: + common: + description: >- + An indication that the radiographically detectable signs of disease are becoming + more prominent over time. + termDef: + term: >- + Radiographic Progressive Disease + source: NCIt + cde_id: C165208 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165208" + term_id: C165208 + term_version: 20.05a + +rpl10: + common: + description: >- + This gene plays a role in protein biosynthesis. It is also involved in signal + transduction. + termDef: + term: >- + RPL10 Gene + source: NCIt + cde_id: C24748 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24748" + term_id: C24748 + term_version: 20.10d + +rpl22: + common: + description: >- + This gene is involved in translation. + termDef: + term: >- + RPL22 Gene + source: NCIt + cde_id: C97761 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97761" + term_id: C97761 + term_version: 20.10d + +rpl5: + common: + description: >- + This gene plays a role in ribosome assembly. + termDef: + term: >- + RPL5 Gene + source: NCIt + cde_id: C107652 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107652" + term_id: C107652 + term_version: 20.10d + +rpn1: + common: + description: >- + This gene plays a role in post-translational protein modification. + termDef: + term: >- + RPN1 Gene + source: NCIt + cde_id: C97290 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97290" + term_id: C97290 + term_version: 20.10d + +rpresponse: + common: + description: >- + The pathologic and/or clinical changes that result from treatment. The changes + may include eradication of detectable disease, stabilization of disease, or + disease progression. + termDef: + term: >- + Disease Response + source: NCIt + cde_id: C50995 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C50995" + term_id: C50995 + term_version: 20.05a + +rsk14_inhibitor_pmd026: + common: + description: >- + An orally bioavailable inhibitor of the serine/threonine kinase p90 ribosomal + S6 kinase (p90RSK; RSK) subtypes 1-4, with high selectivity for RSK subtype + 2 (RSK2), with potential antineoplastic activity. Upon administration of the + RSK1-4 inhibitor PMD-026, this agent targets and inhibits the RSK subtypes, + thereby inhibiting RSK-mediated signaling. This prevents the phosphorylation + and activation of the transcription factor Y-box binding protein-1 (YB-1) and + leads to cell cycle arrest, an induction of apoptosis, and an inhibition of + tumor cell proliferation in RSK-expressing tumor cells. RSK is overexpressed + in a variety of cancers, especially in triple negative breast cancer (TNBC). + It plays a key role in tumor cell proliferation, differentiation, survival, + and metastasis. + termDef: + term: >- + RSK1-4 Inhibitor PMD-026 + source: NCIt + cde_id: C166135 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166135" + term_id: C166135 + term_version: 20.10d + +rspo2: + common: + description: >- + This gene plays a role in both Wnt signaling and embryonic morphogenesis. + termDef: + term: >- + RSPO2 Gene + source: NCIt + cde_id: C106067 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106067" + term_id: C106067 + term_version: 20.10d + +rspo3: + common: + description: >- + This gene is thought to be involved in transport; however, a function has yet + to be elucidated. + termDef: + term: >- + RSPO3 Gene + source: NCIt + cde_id: C24397 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24397" + term_id: C24397 + term_version: 20.10d + +rtpcr: + common: + description: >- + A laboratory procedure in which an RNA strand is first transcribed into a DNA + complement and then subjected to PCR amplification. Transcribing an RNA strand + into a DNA complement is termed reverse transcription and is done by the enzyme + reverse transcriptase. + termDef: + term: >- + Reverse Transcriptase-Polymerase Chain Reaction + source: NCIt + cde_id: C18136 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18136" + term_id: C18136 + term_version: 20.10d + +runx1: + common: + description: >- + This gene plays a role in transcriptional regulation and cytogenetic aberrations + are associated with several leukemias. + termDef: + term: >- + RUNX1 Gene + source: NCIt + cde_id: C18579 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18579" + term_id: C18579 + term_version: 20.10d + +runx1t1: + common: + description: >- + This gene plays a role in transcriptional regulation and hematopoiesis. + termDef: + term: >- + RUNX1T1 Gene + source: NCIt + cde_id: C28570 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28570" + term_id: C28570 + term_version: 20.10d + +russia: + common: + description: >- + A country in northern Asia, bordering the Arctic Ocean, between Europe and the + North Pacific Ocean. + termDef: + term: >- + Russia + source: NCIt + cde_id: C17111 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17111" + term_id: C17111 + term_version: 19.12e + +rutheniumbased_small_molecule_therapeutic_bold100: + common: + description: >- + A ruthenium-based, small molecule that selectively inhibits stress-induced upregulation + of GRP78, with potential antineoplastic activity. Although the exact mechanisms(s) + through which this agent exerts its effects have yet to be fully elucidated, + upon administration, BOLD-100 may selectively inhibit stress-induced upregulation + of GRP78, thereby preventing the activation of multiple GRP78-mediated pathways + and blocking GRP78-induced suppression of apoptotic pathways. This may lead + to the induction of tumor cell apoptosis and slow tumor cell proliferation. + GRP78, the endoplasmic reticulum (ER) chaperone and unfolded protein response + (UPR) regulator, is overexpressed on the surface of a variety of cancer cell + types. Its expression is associated with increased tumor cell survival and proliferation, + as well as angiogenesis and resistance to chemotherapy. + termDef: + term: >- + Ruthenium-based Small Molecule Therapeutic BOLD-100 + source: NCIt + cde_id: C173373 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173373" + term_id: C173373 + term_version: 20.10d + +ruxotemitide: + common: + description: >- + A peptide derived from human lactoferrin, with potential lytic and immunostimulating + activities. Upon transdermal injection directly into the tumor, ruxotemitide + may bind to the tumor cell membranes and subsequently lyse tumor cells, thereby + inducing tumor cell necrosis. In turn, presentation of the tumor antigens to + the immune system may induce systemic innate and adaptive immune responses mediated + by anti-tumor natural killer (NK) cells, cytotoxic T lymphocytes, and natural + killer T (NKT) cells. This may trigger an immune response against tumor associated + antigens on tumors distant from the primary tumor. Human lactoferrin, a 692 + amino acid glycoprotein, belongs to the transferrin family of metal-binding + proteins. + termDef: + term: >- + Ruxotemitide + source: NCIt + cde_id: C90547 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C90547" + term_id: C90547 + term_version: 20.10d + +rwanda: + common: + description: >- + A country in central Africa, between the Democratic Republic of the Congo and + Tanzania and north of Burundi. + termDef: + term: >- + Rwanda + source: NCIt + cde_id: C17112 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17112" + term_id: C17112 + term_version: 19.12e + +rx: + common: + description: >- + Presence of residual tumor after treatment cannot be assessed. + termDef: + term: >- + Stage RX + source: NCIt + cde_id: C139581 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139581" + term_id: C139581 + term_version: 20.05a + +s100a7: + common: + description: >- + This gene is involved in both calcium binding and antimicrobial activity. + termDef: + term: >- + S100A7 Gene + source: NCIt + cde_id: C143078 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143078" + term_id: C143078 + term_version: 20.10d + +sabatolimab: + common: + description: >- + An inhibitor of the inhibitory T-cell receptor T-cell immunoglobulin and mucin + domain-containing protein 3 (TIM-3; hepatitis A virus cellular receptor 2; HAVCR2), + with potential immune checkpoint inhibitory and antineoplastic activities. Upon + administration, sabatolimab binds to TIM-3 expressed on certain immune cells, + including tumor infiltrating lymphocytes (TILs). This abrogates T-cell inhibition, + activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated + tumor cell lysis resulting in a reduction in tumor growth. TIM-3, a transmembrane + protein expressed on certain T-cells, is associated with tumor-mediated immune + suppression. + termDef: + term: >- + Sabatolimab + source: NCIt + cde_id: C124850 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124850" + term_id: C124850 + term_version: 20.10d + +saint_helena_ascension_and_tristan_da_cunha: + common: + description: >- + A group of islands in the South Atlantic Ocean, about midway between South America + and Africa, west of Angola and South Africa. + termDef: + term: >- + Saint Helena, Ascension and Tristan da Cunha + source: NCIt + cde_id: C17164 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17164" + term_id: C17164 + term_version: 19.12e + +saint_kitts_and_nevis: + common: + description: >- + A group of islands in the Caribbean Sea, east of the Virgin Islands and south + of Anguilla. + termDef: + term: >- + Saint Kitts and Nevis + source: NCIt + cde_id: C17885 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17885" + term_id: C17885 + term_version: 19.12e + +saint_lucia: + common: + description: >- + An island between the Caribbean Sea and the North Atlantic Ocean, south of Martinique + and north of Saint Vincent and the Grenadines. + termDef: + term: >- + Saint Lucia + source: NCIt + cde_id: C17113 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17113" + term_id: C17113 + term_version: 19.12e + +saint_pierre_and_miquelon: + common: + description: >- + A country in northern North America, comprised of islands in the North Atlantic + Ocean, south of Newfoundland (Canada). + termDef: + term: >- + Saint Pierre and Miquelon + source: NCIt + cde_id: C17165 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17165" + term_id: C17165 + term_version: 19.12e + +saint_vincent_and_the_grenadines: + common: + description: >- + A group of islands between the Caribbean Sea and the North Atlantic Ocean, south + of Saint Lucia and north of Granada. + termDef: + term: >- + Saint Vincent and the Grenadines + source: NCIt + cde_id: C17114 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17114" + term_id: C17114 + term_version: 19.12e + +saliva: + common: + description: >- + The watery fluid in the mouth made by the salivary glands. Saliva moistens food + to help digestion and it helps protect the mouth against infections. + termDef: + term: >- + Saliva + source: NCIt + cde_id: C13275 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13275" + term_id: C13275 + term_version: 20.10d + +salivary_duct_carcinoma: + common: + description: >- + An aggressive, high grade adenocarcinoma that arises from the salivary glands. + It usually affects elderly males and presents as a rapidly enlarging mass. It + metastasizes to regional lymph nodes and distant anatomic sites. + termDef: + term: >- + Salivary Duct Carcinoma + source: NCIt + cde_id: C5904 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C5904" + term_id: C5904 + term_version: 20.05a + +sall4: + common: + description: >- + This gene plays a role in both transcriptional regulation and stem cell maintenance. + termDef: + term: >- + SALL4 Gene + source: NCIt + cde_id: C112905 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112905" + term_id: C112905 + term_version: 20.10d + +salt_lymphoma: + common: + description: >- + A low-grade, extranodal marginal zone B-cell lymphoma of the mucosa-associated + lymphoid tissue that arises from the skin. It usually presents with multifocal + papular or nodular lesions in the arms or trunk. It rarely disseminates to + internal organs or progresses to high grade lymphoma. + termDef: + term: >- + Primary Cutaneous Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue + source: NCIt + cde_id: C7230 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7230" + term_id: C7230 + term_version: 20.05a + +samoa: + common: + description: >- + A group of islands in the South Pacific Ocean, about half way from Hawaii to + New Zealand, west of American Samoa. + termDef: + term: >- + Samoa + source: NCIt + cde_id: C17740 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17740" + term_id: C17740 + term_version: 19.12e + +samrotamab_vedotin: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a proprietary monoclonal antibody + against a tumor-associated antigen (TAA) linked to an as of yet undisclosed + cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration, + the monoclonal antibody moiety of ABBV-085 targets and binds to the TAA expressed + on tumor cells. Upon binding and internalization, the cytotoxic agent is released + and kills the TAA-expressing cancer cells, through an as of yet unknown mechanism + of action. + termDef: + term: >- + Samrotamab Vedotin + source: NCIt + cde_id: C124134 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124134" + term_id: C124134 + term_version: 20.10d + +samuraciclib: + common: + description: >- + An orally available, selective inhibitor of cyclin-dependent kinase 7 (CDK7) + with potential antineoplastic activity. Upon oral administration, samuraciclib + selectively and competitively binds to the CDK7 ATP binding site, thereby inhibiting + CDK7-mediated signaling. CDK7, a serine/threonine kinase, plays a role in controlling + cell cycle progression, transcriptional regulation, and promotes the expression + of key oncogenes such as c-Myc through the phosphorylation of RNA polymerase + II. Inhibition of CDK7 may inhibit tumor cell proliferation in certain cancers + that are dependent on CDK7-mediated transcriptional regulation and signaling. + termDef: + term: >- + Samuraciclib + source: NCIt + cde_id: C155652 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155652" + term_id: C155652 + term_version: 20.10d + +san_marino: + common: + description: >- + A country in southern Europe, an enclave in central Italy. + termDef: + term: >- + San Marino + source: NCIt + cde_id: C17115 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17115" + term_id: C17115 + term_version: 19.12e + +sao_tome_and_principe: + common: + description: >- + A country in western Africa, comprised of islands in the Gulf of Guinea, straddling + the Equator, west of Gabon. + termDef: + term: >- + Sao Tome and Principe + source: NCIt + cde_id: C17116 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17116" + term_id: C17116 + term_version: 19.12e + +sarcoma: + common: + description: >- + A usually aggressive malignant neoplasm of the soft tissue or bone. It arises + from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas + occur in both children and adults. The prognosis depends largely on the degree + of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, + leiomyosarcoma, osteosarcoma, and chondrosarcoma. + termDef: + term: >- + Sarcoma + source: NCIt + cde_id: C9118 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9118" + term_id: C9118 + term_version: 19.12e + +sarcoma_botryoides: + common: + description: >- + A morphologic variant of embryonal rhabdomyosarcoma arising from organs with + a mucosal epithelial surface. It is characterized by the formation of a cambium + layer in the affected tissue and polypoid nodules within an abundant myxoid + stroma. + termDef: + term: >- + Botryoid-Type Embryonal Rhabdomyosarcoma + source: NCIt + cde_id: C9150 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9150" + term_id: C9150 + term_version: 20.05a + +sarcoma_nos: + common: + description: >- + A usually aggressive malignant neoplasm of the soft tissue or bone. It arises + from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas + occur in both children and adults. The prognosis depends largely on the degree + of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, + leiomyosarcoma, osteosarcoma, and chondrosarcoma. + termDef: + term: >- + Sarcoma + source: NCIt + cde_id: C9118 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9118" + term_id: C9118 + term_version: 20.05a + +sarcomatoid_carcinoma: + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of spindle cells + and anaplastic morphologic features. Giant cells and a sarcomatous component + may also be present. + termDef: + term: >- + Sarcomatoid Carcinoma + source: NCIt + cde_id: C27004 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27004" + term_id: C27004 + term_version: 20.05a + +sarcomatoid_mesothelioma: + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of spindle cells. Anaplastic morphologic features and multinucleated + malignant cells may also be seen. + termDef: + term: >- + Sarcomatoid Mesothelioma + source: NCIt + cde_id: C45655 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45655" + term_id: C45655 + term_version: 20.05a + +sarcomatosis_nos: + common: + description: >- + The occurrence of several sarcomas in different anatomic locations. + termDef: + term: >- + Sarcomatosis + source: NCIt + cde_id: C4243 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4243" + term_id: C4243 + term_version: 20.05a + +sasanlimab: + common: + description: >- + An inhibitor of the human inhibitory receptor programmed cell death 1 (PD-1; + PDCD1), with potential immune checkpoint inhibitory and antineoplastic activities. + Upon administration, sasanlimab targets and binds to PD-1 and blocks the interaction + between PD-1 and its ligands, PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). + This prevents the activation of PD-1 and its downstream signaling pathways. + This may restore immune function through the activation of natural killer (NK) + cells and cytotoxic T-lymphocytes (CTLs) against tumor cells. PD-1, an inhibitory + receptor belonging to the B7-receptor family, is expressed on activated T-lymphocytes, + B-cells and NK cells; it functions as an immune checkpoint that negatively regulates + T-cell activation and effector function when activated by its ligands, and plays + an important role in tumor evasion from host immunity. + termDef: + term: >- + Sasanlimab + source: NCIt + cde_id: C124058 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124058" + term_id: C124058 + term_version: 20.10d + +saudi_arabia: + common: + description: >- + A country in the Middle East, bordering the Persian Gulf and the Red Sea, north + of Yemen. + termDef: + term: >- + Saudi Arabia + source: NCIt + cde_id: C17117 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17117" + term_id: C17117 + term_version: 19.12e + +sbds: + common: + description: >- + This gene plays a role in ribosome formation. + termDef: + term: >- + SBDS Gene + source: NCIt + cde_id: C97767 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97767" + term_id: C97767 + term_version: 20.10d + +scalp: + common: + description: >- + The skin which covers the top of the head and which is usually covered by hair. + termDef: + term: >- + Scalp + source: NCIt + cde_id: C89807 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C89807" + term_id: C89807 + term_version: 20.05a + +schmincke_tumor: + common: + description: >- + A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but + also in the tonsils and rarely in other anatomic sites. It is characterized + by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, + syncytial growth pattern, and a lymphoplasmacytic infiltrate. + termDef: + term: >- + Nasopharyngeal-Type Undifferentiated Carcinoma + source: NCIt + cde_id: C4107 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4107" + term_id: C4107 + term_version: 20.05a + +schneiderian_carcinoma: + common: + description: >- + A squamous cell carcinoma of the sinonasal tract characterized by a plexiform + or ribbon-like growth pattern, cytological atypia, and lack of histological + evidence of keratinization. + termDef: + term: >- + Non-Keratinizing Sinonasal Squamous Cell Carcinoma + source: NCIt + cde_id: C54287 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54287" + term_id: C54287 + term_version: 20.05a + +schneiderian_papilloma_inverted: + common: + description: >- + A benign neoplasm that arises from the ciliated respiratory mucosa that lines + the nasal cavity or paranasal sinuses. It results from the invagination and + proliferation of epithelial cells in the underlying stroma. Clinical manifestations + include nasal obstruction, epistaxis, and anosmia. It has the tendency to recur + and extend to adjacent structures. Inverted papillomas are occasionally associated + with the development or presence of carcinomas, usually squamous cell carcinomas. + termDef: + term: >- + Sinonasal Inverted Schneiderian Papilloma + source: NCIt + cde_id: C6871 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6871" + term_id: C6871 + term_version: 20.05a + +schneiderian_papilloma_nos: + common: + description: >- + A benign neoplasm that arises from the ciliated respiratory mucosa that lines + the nasal cavity and paranasal sinuses. It is classified as inverted papilloma, + oncocytic papilloma, and exophytic papilloma. Clinical manifestations include + nasal obstruction, epistaxis, and anosmia. + termDef: + term: >- + Sinonasal Schneiderian Papilloma + source: NCIt + cde_id: C4117 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4117" + term_id: C4117 + term_version: 20.05a + +schwannoma_nos: + common: + description: >- + A benign, usually encapsulated slow growing tumor composed of Schwann cells. It + affects peripheral and cranial nerves. It recurs infrequently and only rare + cases associated with malignant transformation have been reported. + termDef: + term: >- + Schwannoma + source: NCIt + cde_id: C3269 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3269" + term_id: C3269 + term_version: 20.05a + +scirrhous_adenocarcinoma: + common: + description: >- + An infiltrating adenocarcinoma characterized by the presence of desmoplastic + stromal reaction. + termDef: + term: >- + Scirrhous Adenocarcinoma + source: NCIt + cde_id: C2928 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2928" + term_id: C2928 + term_version: 20.05a + +scirrhous_carcinoma: + common: + description: >- + An infiltrating adenocarcinoma characterized by the presence of desmoplastic + stromal reaction. + termDef: + term: >- + Scirrhous Adenocarcinoma + source: NCIt + cde_id: C2928 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2928" + term_id: C2928 + term_version: 20.05a + +sclerosing_epithelioid_fibrosarcoma: + common: + description: >- + A well-circumscribed rare morphologic variant of fibrosarcoma, that arises from + the soft tissue. It is characterized by the presence of nests of malignant epithelioid + fibroblasts and sclerotic collagen stroma formation. + termDef: + term: >- + Sclerosing Epithelioid Fibrosarcoma + source: NCIt + cde_id: C49027 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49027" + term_id: C49027 + term_version: 20.05a + +sclerosing_hemangioma: + common: + description: >- + A solitary, slowly growing, nodular tumor most often affecting the extremities. + It is composed of fibrous and histiocytic cells which infiltrate the dermis + and occasionally the underlying subcutaneous tissue. Usually local excision + is curative. Recurrences are reported only in a small minority of cases. + termDef: + term: >- + Skin Fibrous Histiocytoma + source: NCIt + cde_id: C6801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6801" + term_id: C6801 + term_version: 20.05a + +sclerosing_hepatic_carcinoma: + common: + description: >- + An uncommon type of hepatocelluar carcinoma, morphologically characterized by + significant fibrosis around the sinusoid-like spaces and atrophy of the tumor + trabeculae. + termDef: + term: >- + Scirrhous Hepatocellular Carcinoma + source: NCIt + cde_id: C27388 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27388" + term_id: C27388 + term_version: 20.05a + +sclerosing_liposarcoma: + common: + description: >- + A morphologic variant of well differentiated liposarcoma occurring most often + in the retroperitoneum and paratesticular area. It is characterized by the + presence of bizarre hyperchromatic stromal cells and rare multivacuolated lipoblasts + within a fibrous stroma. + termDef: + term: >- + Sclerosing Liposarcoma + source: NCIt + cde_id: C6507 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6507" + term_id: C6507 + term_version: 20.05a + +sclerosing_rhabdomyosarcoma: + common: + description: >- + An uncommon variant of rhabdomyosarcoma with sclerosing morphology. It usually + arises from the limbs. + termDef: + term: >- + Sclerosing Rhabdomyosarcoma + source: NCIt + cde_id: C121655 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121655" + term_id: C121655 + term_version: 20.05a + +sclerosing_stromal_tumor: + common: + description: >- + A benign ovarian stromal tumor characterized by the presence of cellular areas + which contain fibroblasts and round cells. The cellular areas are separated + by sclerotic or edematous hypocellular tissue. Symptoms include abdominal discomfort + and menstrual abnormalities. + termDef: + term: >- + Ovarian Sclerosing Stromal Tumor + source: NCIt + cde_id: C4204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4204" + term_id: C4204 + term_version: 20.05a + +sclerosing_sweat_duct_carcinoma: + common: + description: >- + A low grade adenocarcinoma with ductal differentiation, arising from the sweat + glands. It presents as a scar usually in the face. It is characterized by the + formation of small ducts and it frequently involves nerves and perineural spaces. + termDef: + term: >- + Microcystic Adnexal Carcinoma + source: NCIt + cde_id: C7581 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7581" + term_id: C7581 + term_version: 20.05a + +sclerosis: + common: + description: >- + A pathological hardening or thickening of tissue, especially that of the interstitial + substance. + termDef: + term: >- + Sclerosis + source: NCIt + cde_id: C69309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C69309" + term_id: C69309 + term_version: 20.05a + +scrotum_nos: + common: + description: >- + The musculocutaneous pouch that encloses the testicles. + termDef: + term: >- + Scrotum + source: NCIt + cde_id: C12785 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12785" + term_id: C12785 + term_version: 20.05a + +scrstringent_complete_response: + common: + description: >- + The confirmed disappearance of all signs of cancer, and absence of molecular + or cytogenetic marker of disease, in response to treatment with additional biochemical, + immunological and histopathological analyses to verify the CR. + termDef: + term: >- + Stringent Complete Response + source: NCIt + cde_id: C123614 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123614" + term_id: C123614 + term_version: 20.05a + +sdc4: + common: + description: >- + This gene is involved in cell-matrix interactions. + termDef: + term: >- + SDC4 Gene + source: NCIt + cde_id: C101431 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101431" + term_id: C101431 + term_version: 20.10d + +sdf1_receptor_antagonist_ptx9908: + common: + description: >- + A stromal cell-derived factor 1 (SDF-1; CXCL12) analog and inhibitor of C-X-C + chemokine receptor type 4 (CXCR4), with potential antineoplastic activity. Upon + administration, PTX-9908 selectively targets and binds to CXCR4, thereby preventing + the binding of CXCR4 to its ligand SDF-1. This inhibits receptor activation + and results in decreased proliferation and migration of CXCR4-overexpressing + tumor cells. The G protein-coupled receptor CXCR4, which is overexpressed in + several tumor cell types, promotes tumor angiogenesis, tumor cell proliferation, + survival, invasion and metastasis. SDF-1, a major chemotactic factor, plays + a key role in mediating cell trafficking via selective binding to CXCR4. + termDef: + term: >- + SDF-1 Receptor Antagonist PTX-9908 + source: NCIt + cde_id: C170746 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170746" + term_id: C170746 + term_version: 20.10d + +sdha: + common: + description: >- + This gene is involved in the mitochondrial respiratory chain. + termDef: + term: >- + SDHA Gene + source: NCIt + cde_id: C103873 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C103873" + term_id: C103873 + term_version: 20.10d + +sdhaf2: + common: + description: >- + This gene is involved in the electron transport chain. + termDef: + term: >- + SDHAF2 Gene + source: NCIt + cde_id: C97770 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97770" + term_id: C97770 + term_version: 20.10d + +sdhb: + common: + description: >- + This gene plays a role in electron transport in the mitochondria. + termDef: + term: >- + SDHB Gene + source: NCIt + cde_id: C97773 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97773" + term_id: C97773 + term_version: 20.10d + +sdhc: + common: + description: >- + This gene is involved in mitochondrial electron transport. + termDef: + term: >- + SDHC Gene + source: NCIt + cde_id: C97776 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97776" + term_id: C97776 + term_version: 20.10d + +sdhd: + common: + description: >- + This gene plays a role in the localization of succinate dehydrogenase activity. + termDef: + term: >- + SDHD Gene + source: NCIt + cde_id: C97779 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97779" + term_id: C97779 + term_version: 20.10d + +sdstable_disease: + common: + description: >- + Cancer that is neither decreasing nor increasing in extent or severity. + termDef: + term: >- + Stable Disease + source: NCIt + cde_id: C18213 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18213" + term_id: C18213 + term_version: 20.05a + +sebaceous_adenocarcinoma: + common: + description: >- + An adenocarcinoma with sebaceous differentiation. It presents as a painless + mass and it may be multifocal. It grows in the ocular adnexae and in the skin + of head and neck, trunk, genitals, and extremities. It is characterized by the + presence of malignant cells with multivesicular and clear cytoplasm. It may + recur and metastasize. + termDef: + term: >- + Sebaceous Carcinoma + source: NCIt + cde_id: C40310 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40310" + term_id: C40310 + term_version: 20.05a + +sebaceous_adenoma: + common: + description: >- + A benign, well circumscribed neoplasm arising from the sebaceous glands. It + usually presents as a small yellowish tumor in the sun exposed skin of head + and neck. It is characterized by the presence of sebaceous cells aggregates + with a peripheral rim of basaloid cells. + termDef: + term: >- + Sebaceous Adenoma + source: NCIt + cde_id: C4174 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4174" + term_id: C4174 + term_version: 20.05a + +sebaceous_carcinoma: + common: + description: >- + An adenocarcinoma with sebaceous differentiation. It presents as a painless + mass and it may be multifocal. It grows in the ocular adnexae and in the skin + of head and neck, trunk, genitals, and extremities. It is characterized by the + presence of malignant cells with multivesicular and clear cytoplasm. It may + recur and metastasize. + termDef: + term: >- + Sebaceous Carcinoma + source: NCIt + cde_id: C40310 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40310" + term_id: C40310 + term_version: 20.05a + +sebaceous_epithelioma: + common: + description: >- + A basal cell carcinoma of the skin that is characterized by sebaceous differentiation. + termDef: + term: >- + Skin Basal Cell Carcinoma with Sebaceous Differentiation + source: NCIt + cde_id: C4346 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4346" + term_id: C4346 + term_version: 20.05a + +secondary_carcinoma: + common: + description: >- + A carcinoma that arises from a pre-existing lower grade epithelial lesion, or + as a result of a primary carcinoma that has spread to secondary sites, or due + to a complication of a cancer treatment. + termDef: + term: >- + Secondary Carcinoma + source: NCIt + cde_id: C36310 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36310" + term_id: C36310 + term_version: 20.05a + +secretory_carcinoma_of_breast: + common: + description: >- + A rare, low grade invasive adenocarcinoma of the breast characterized by the + presence of cells that secrete milk-like material. Morphologically, it usually + appears as a circumscribed lesion, composed of cystic spaces, tubular structures, + and solid areas. + termDef: + term: >- + Secretory Breast Carcinoma + source: NCIt + cde_id: C4189 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4189" + term_id: C4189 + term_version: 20.05a + +secretory_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of epithelial differentiation + and numerous intracellular PAS positive bodies that are rich in glycogen. + termDef: + term: >- + Secretory Meningioma + source: NCIt + cde_id: C4718 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4718" + term_id: C4718 + term_version: 20.05a + +segmented_neutrophil: + common: + description: >- + The determination of the amount of segmented neutrophils present in a sample. + termDef: + term: >- + Segmented Neutrophil Count + source: NCIt + cde_id: C81997 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C81997" + term_id: C81997 + term_version: 20.10d + +seizures: + common: + description: >- + Sudden, involuntary skeletal muscular contractions of cerebral or brain stem + origin. + termDef: + term: >- + Seizure + source: NCIt + cde_id: C2962 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2962" + term_id: C2962 + term_version: 20.05a + +selective_estrogen_receptor_degrader_lx039: + common: + description: >- + An orally available selective estrogen receptor degrader/downregulator (SERD), + with potential antineoplastic activity. Upon oral administration, SERD LX-039 + specifically targets and binds to the estrogen receptor (ER) and induces a conformational + change that results in ER degradation. This prevents ER-mediated signaling and + inhibits both the growth and survival of ER-expressing cancer cells. + termDef: + term: >- + Selective Estrogen Receptor Degrader LX-039 + source: NCIt + cde_id: C168606 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168606" + term_id: C168606 + term_version: 20.10d + +selective_estrogen_receptor_degrader_ly3484356: + common: + description: >- + An orally available selective estrogen receptor degrader (SERD), with potential + antineoplastic activity. Upon oral administration, LY3484356 specifically targets + and binds to the estrogen receptor (ER) and induces a conformational change + that results in ER degradation. This prevents ER-mediated signaling and inhibits + both the growth and survival of ER-expressing cancer cells. + termDef: + term: >- + Selective Estrogen Receptor Degrader LY3484356 + source: NCIt + cde_id: C174042 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174042" + term_id: C174042 + term_version: 20.10d + +seminoma_anaplastic: + common: + description: >- + A seminoma of the testis characterized by increased cellular pleomorphism, high + mitotic activity, and a non-prominent stromal lymphocytic infiltrate. + termDef: + term: >- + Testicular Seminoma with High Mitotic Index + source: NCIt + cde_id: C39920 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39920" + term_id: C39920 + term_version: 20.05a + +seminoma_nos: + common: + description: >- + A radiosensitive malignant germ cell tumor found in the testis (especially undescended), + and extragonadal sites (anterior mediastinum and pineal gland). It is characterized + by the presence of uniform cells with clear or dense cytoplasm which contains + glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic + germ cells form aggregates separated by fibrous septa. The fibrous septa contain + chronic inflammatory cells, mainly lymphocytes. + termDef: + term: >- + Seminoma + source: NCIt + cde_id: C9309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9309" + term_id: C9309 + term_version: 20.05a + +seminoma_with_high_mitotic_index: + common: + description: >- + A seminoma of the testis characterized by increased cellular pleomorphism, high + mitotic activity, and a non-prominent stromal lymphocytic infiltrate. + termDef: + term: >- + Testicular Seminoma with High Mitotic Index + source: NCIt + cde_id: C39920 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39920" + term_id: C39920 + term_version: 20.05a + +senegal: + common: + description: >- + A country in western Africa, bordering the North Atlantic Ocean, between Guinea-Bissau + and Mauritania. + termDef: + term: >- + Senegal + source: NCIt + cde_id: C17121 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17121" + term_id: C17121 + term_version: 19.12e + +sensory_changes: + common: + description: >- + An alteration in the perceptual senses an individual. + termDef: + term: >- + Sensory Change + source: NCIt + cde_id: C157429 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157429" + term_id: C157429 + term_version: 20.05a + +sequencing_nos: + common: + description: >- + The determination of the sequence of component residues in a macromolecule, + e.g. amino acids in a protein or nucleotide bases in DNA/RNA or the computational + analysis performed to determine the similarities between nonidentical proteins + or molecules of DNA or RNA. + termDef: + term: >- + Sequence Analysis + source: NCIt + cde_id: C17565 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17565" + term_id: C17565 + term_version: 20.10d + +serbia: + common: + description: >- + A republic in southeastern Europe, between Romania and Bosnia and Herzegovina. + termDef: + term: >- + Serbia + source: NCIt + cde_id: C64377 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64377" + term_id: C64377 + term_version: 19.12e + +serclutamab_talirine: + common: + description: >- + A antibody drug conjugate (ADC) consisting of serclutamab, an affinity-matured + humanized monoclonal antibody directed against the epidermal growth factor receptor + (EGFR) conjugated to a talirine, a cytotoxic, DNA minor groove crosslinking + agent and pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. + Upon intravenous administration of serclutamab talirine, the serclutamab moiety + targets and binds to EGFR on tumor cell surfaces. Following receptor internalization + and lysosome-mediated cleavage, talirine is released. In turn, the imine groups + of the PBD moiety bind to the N2 positions of guanines on opposite strands of + DNA. This induces DNA strand breaks, inhibits DNA replication, leads to G2/M + cell cycle arrest, induces cell death, and inhibits the proliferation of EGFR-overexpressing + tumor cells. EGFR, a receptor tyrosine kinase (RTK) that is overexpressed by + a variety of cancers, plays a key role in tumor cell proliferation and survival. + termDef: + term: >- + Serclutamab Talirine + source: NCIt + cde_id: C150590 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150590" + term_id: C150590 + term_version: 20.10d + +serd_znc5: + common: + description: >- + An orally available selective estrogen receptor degrader/downregulator (SERD), + with potential antineoplastic activity. Upon oral administration, SERD ZN-c5 + specifically targets and binds to the estrogen receptor (ER) and induces a conformational + change that results in ER degradation. This prevents ER-mediated signaling and + inhibits both the growth and survival of ER-expressing cancer cells. + termDef: + term: >- + SERD ZN-c5 + source: NCIt + cde_id: C167267 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167267" + term_id: C167267 + term_version: 20.10d + +seromucinous_carcinoma: + common: + description: >- + A malignant mixed epithelial neoplasm that arises from the ovary and is composed + predominantly of serous and endocervical-type mucinous epithelium. + termDef: + term: >- + Ovarian Seromucinous Carcinoma + source: NCIt + cde_id: C40090 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40090" + term_id: C40090 + term_version: 20.05a + +serous_adenocarcinoma_nos: + common: + description: >- + A malignant serous cystic neoplasm usually involving the ovary or the pancreas. + It is characterized by the presence of invasive malignant glandular epithelial + cells which often form papillary structures. + termDef: + term: >- + Serous Cystadenocarcinoma + source: NCIt + cde_id: C3778 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3778" + term_id: C3778 + term_version: 20.05a + +serous_adenofibroma_nos: + common: + description: >- + A benign or borderline adenofibroma characterized by the presence of serous + secretory cells and minute cystic spaces filled with watery fluid. A representative + example is the ovarian serous adenofibroma. + termDef: + term: >- + Serous Adenofibroma + source: NCIt + cde_id: C67090 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67090" + term_id: C67090 + term_version: 20.05a + +serous_borderline_tumormicropapillary_variant: + common: + description: >- + A non-invasive serous neoplasm that arises from the ovary and shows micropapillary + and/or cribriform architectural patterns. It is composed of round epithelial + cells with scant cytoplasm and moderate nuclear atypia. + termDef: + term: >- + Borderline Ovarian Serous Tumor-Micropapillary Variant/Non-Invasive Low Grade + Ovarian Serous Carcinoma + source: NCIt + cde_id: C122585 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122585" + term_id: C122585 + term_version: 20.05a + +serous_carcinoma_nos: + common: + description: >- + A malignant serous cystic neoplasm usually involving the ovary or the pancreas. + It is characterized by the presence of invasive malignant glandular epithelial + cells which often form papillary structures. + termDef: + term: >- + Serous Cystadenocarcinoma + source: NCIt + cde_id: C3778 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3778" + term_id: C3778 + term_version: 20.05a + +serous_cystadenocarcinoma_nos: + common: + description: >- + A malignant serous cystic neoplasm usually involving the ovary or the pancreas. + It is characterized by the presence of invasive malignant glandular epithelial + cells which often form papillary structures. + termDef: + term: >- + Serous Cystadenocarcinoma + source: NCIt + cde_id: C3778 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3778" + term_id: C3778 + term_version: 20.05a + +serous_cystadenoma_borderline_malignancy: + common: + description: >- + A serous cystic glandular epithelial neoplasm of low malignant potential. It + is characterized by the presence of atypical or malignant glandular epithelial + cells with an absence of stromal invasion. + termDef: + term: >- + Borderline Serous Cystadenoma + source: NCIt + cde_id: C4177 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4177" + term_id: C4177 + term_version: 20.05a + +serous_cystadenoma_nos: + common: + description: >- + A serous neoplasm in which the cysts and papillae are lined by a single layer + of cells without atypia, architectural complexity or invasion. + termDef: + term: >- + Serous Cystadenoma + source: NCIt + cde_id: C3783 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3783" + term_id: C3783 + term_version: 20.05a + +serous_cystoma: + common: + description: >- + A serous neoplasm in which the cysts and papillae are lined by a single layer + of cells without atypia, architectural complexity or invasion. + termDef: + term: >- + Serous Cystadenoma + source: NCIt + cde_id: C3783 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3783" + term_id: C3783 + term_version: 20.05a + +serous_endometrial_intraepithelial_carcinoma: + common: + description: >- + A precursor of endometrial serous adenocarcinoma characterized by the replacement + of the normal endometrial cells by malignant glandular cells that resemble the + malignant cells of invasive serous adenocarcinoma. The endometrial neoplastic + process is non-invasive. It may coexist with invasive endometrial adenocarcinoma + or can be associated with metastases outside the uterus, in the absence of invasive + endometrial carcinoma. + termDef: + term: >- + Serous Endometrial Intraepithelial Carcinoma + source: NCIt + cde_id: C40152 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40152" + term_id: C40152 + term_version: 20.05a + +serous_microcystic_adenoma: + common: + description: >- + A serous neoplasm in which the cysts and papillae are lined by a single layer + of cells without atypia, architectural complexity or invasion. + termDef: + term: >- + Serous Cystadenoma + source: NCIt + cde_id: C3783 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3783" + term_id: C3783 + term_version: 20.05a + +serous_papillary_cystic_tumor_of_borderline_malignancy: + common: + description: >- + A low malignant potential cystic serous epithelial neoplasm arising from the + ovary. Cases with identical morphology have been described arising from the + peritoneum as well. It is characterized by an atypical epithelial proliferation + and a papillary growth pattern. There is no evidence of destructive stromal + invasion. + termDef: + term: >- + Borderline Papillary Serous Cystadenoma + source: NCIt + cde_id: C4183 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4183" + term_id: C4183 + term_version: 20.05a + +serous_surface_papillary_carcinoma: + common: + description: >- + An invasive serous adenocarcinoma arising from the ovary and rarely the peritoneum. + Morphologically, it may be a well, moderately, or poorly differentiated neoplasm. + It is characterized by a papillary growth pattern often associated with the + presence of psammoma bodies. + termDef: + term: >- + Serous Surface Papillary Carcinoma + source: NCIt + cde_id: C4182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4182" + term_id: C4182 + term_version: 20.05a + +serous_surface_papilloma: + common: + description: >- + A non-invasive papillary serous epithelial neoplasm usually arising from the + ovary. + termDef: + term: >- + Serous Surface Papilloma + source: NCIt + cde_id: C4181 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4181" + term_id: C4181 + term_version: 20.05a + +serous_tubal_intraepithelial_carcinoma: + common: + description: >- + A non-invasive serous carcinoma arising from the fallopian tube. + termDef: + term: >- + Serous Tubal Intraepithelial Carcinoma + source: NCIt + cde_id: C126449 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126449" + term_id: C126449 + term_version: 20.05a + +serous_tumor_nos_of_low_malignant_potential: + common: + description: >- + A serous cystic glandular epithelial neoplasm of low malignant potential. It + is characterized by the presence of atypical or malignant glandular epithelial + cells with an absence of stromal invasion. + termDef: + term: >- + Borderline Serous Cystadenoma + source: NCIt + cde_id: C4177 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4177" + term_id: C4177 + term_version: 20.05a + +serplulimab: + common: + description: >- + A humanized monoclonal antibody directed against the negative immunoregulatory + human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with + potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, + serplulimab targets, binds to and inhibits PD-1 and its downstream signaling + pathways. This may restore immune function through the activation of T-cells + and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane + protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions + as an immune checkpoint that negatively regulates T-cell activation and effector + function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) + and 2 (PD-L2); it plays an important role in tumor evasion from host immunity. + termDef: + term: >- + Serplulimab + source: NCIt + cde_id: C156738 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156738" + term_id: C156738 + term_version: 20.10d + +serrated_adenoma: + common: + description: >- + An adenoma that arises from the large intestine and the appendix. It is characterized + by prominent serration of the glands and the presence of generalized low-grade + dysplasia. + termDef: + term: >- + Traditional Serrated Adenoma + source: NCIt + cde_id: C38458 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38458" + term_id: C38458 + term_version: 20.05a + +sertoli_cell_adenoma: + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +sertoli_cell_tumor_nos: + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +sertolileydig_cell_tumor_nos: + common: + description: >- + A benign or malignant sex cord-stromal tumor arising from the ovary. It is characterized + by the presence of neoplastic Leydig cells. Signs and symptoms include hirsutism, + menorrhagia and metrorrhagia. It may be associated with trisomy 8. + termDef: + term: >- + Ovarian Sertoli-Leydig Cell Tumor + source: NCIt + cde_id: C2880 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2880" + term_id: C2880 + term_version: 20.05a + +serum: + common: + description: >- + The clear portion of the blood that remains after the removal of the blood cells + and the clotting proteins. + termDef: + term: >- + Serum + source: NCIt + cde_id: C13325 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13325" + term_id: C13325 + term_version: 20.10d + +serum_free_immunoglobulin_light_chain_kappa: + common: + description: >- + The determination of the amount of free kappa light chain present in a sample. + termDef: + term: >- + Free Kappa Light Chain Measurement + source: NCIt + cde_id: C98730 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98730" + term_id: C98730 + term_version: 20.10d + +serum_free_immunoglobulin_light_chain_lambda: + common: + description: >- + The determination of the amount of free lambda light chain present in a sample. + termDef: + term: >- + Free Lambda Light Chain Measurement + source: NCIt + cde_id: C98732 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98732" + term_id: C98732 + term_version: 20.10d + +serum_free_immunoglobulin_light_chain_nos: + common: + description: >- + The determination of the amount of immunoglobulin light chain present in a sample. + termDef: + term: >- + Immunoglobulin Light Chain Measurement + source: NCIt + cde_id: C147376 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C147376" + term_id: C147376 + term_version: 20.10d + +sessile_serrated_adenoma: + common: + description: >- + A polyp that arises from the large intestine and the appendix. It is characterized + by the presence of serrated glands and the absence of generalized dysplasia. Some + authors have suggested that it is a precursor lesion for some colorectal adenocarcinomas + with microsatellite instability. + termDef: + term: >- + Sessile Serrated Adenoma/Polyp + source: NCIt + cde_id: C96414 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96414" + term_id: C96414 + term_version: 20.05a + +sessile_serrated_polyp: + common: + description: >- + A polyp that arises from the large intestine and the appendix. It is characterized + by the presence of serrated glands and the absence of generalized dysplasia. Some + authors have suggested that it is a precursor lesion for some colorectal adenocarcinomas + with microsatellite instability. + termDef: + term: >- + Sessile Serrated Adenoma/Polyp + source: NCIt + cde_id: C96414 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96414" + term_id: C96414 + term_version: 20.05a + +set: + common: + description: >- + This gene is involved in apoptosis, biogenesis, DNA replication and nuclear + organization. + termDef: + term: >- + SET Gene + source: NCIt + cde_id: C24801 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24801" + term_id: C24801 + term_version: 20.10d + +setbp1: + common: + description: >- + This gene may be involved in the modulation of protein SET activity. + termDef: + term: >- + SETBP1 Gene + source: NCIt + cde_id: C106635 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106635" + term_id: C106635 + term_version: 20.10d + +setd2: + common: + description: >- + This gene is involved in epigenetic control of gene expression. + termDef: + term: >- + SETD2 Gene + source: NCIt + cde_id: C73662 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73662" + term_id: C73662 + term_version: 20.10d + +settle: + common: + description: >- + A rare, slow growing, primary malignant tumor of the thyroid gland characterized + by a lobulated architectural pattern and the presence of a biphasic cellular + population composed of spindle epithelial cells and glandular cells. A small + number of cases are composed exclusively of spindle epithelial cells or glandular + cells. + termDef: + term: >- + Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation + source: NCIt + cde_id: C46105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46105" + term_id: C46105 + term_version: 20.05a + +severe: + common: + description: >- + Intensely bad or unpleasant in degree, quality or extent. + termDef: + term: >- + Severe + source: NCIt + cde_id: C70667 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C70667" + term_id: C70667 + term_version: 20.10d + +sex_cord_tumor_nos: + common: + description: >- + A neoplasm arising in the ovary or testis. It is composed of granulosa cells, + Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute + the only cellular component that is present in the neoplasm or it may be mixed + with other cell types in various combinations. The prognosis can not always + be predicted on histologic grounds alone. Approximately, 10% of these tumors + may metastasize. Representative examples include granulosa cell tumor, Leydig + cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group. + termDef: + term: >- + Sex Cord-Stromal Tumor + source: NCIt + cde_id: C3794 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3794" + term_id: C3794 + term_version: 20.05a + +sex_cordgonadal_stromal_tumor_incompletely_differentiated: + common: + description: >- + A sex cord-stromal tumor of the testis in which the neoplastic cells do not + show specific differentiation. + termDef: + term: >- + Unclassified Testicular Sex Cord-Stromal Tumor + source: NCIt + cde_id: C66748 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66748" + term_id: C66748 + term_version: 20.05a + +sex_cordgonadal_stromal_tumor_mixed_forms: + common: + description: >- + A sex cord-stromal tumor of the testis which may contain any combination of + cell types, for example Sertoli cells, Leydig cells, and granulosa cells. Symptoms + include testicular swelling and gynecomastia. + termDef: + term: >- + Mixed Testicular Sex Cord-Stromal Tumor + source: NCIt + cde_id: C66991 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66991" + term_id: C66991 + term_version: 20.05a + +sex_cordgonadal_stromal_tumor_nos: + common: + description: >- + A benign or malignant neoplasm that arises from the ovary and is composed of + granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative + examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor. + termDef: + term: >- + Ovarian Sex Cord-Stromal Tumor + source: NCIt + cde_id: C4862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4862" + term_id: C4862 + term_version: 20.05a + +seychelles: + common: + description: >- + A country in eastern Africa, comprised of a group of islands in the Indian Ocean, + northeast of Madagascar and east of Kenya. + termDef: + term: >- + Seychelles + source: NCIt + cde_id: C17129 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17129" + term_id: C17129 + term_version: 19.12e + +sezary_disease: + common: + description: >- + A generalized peripheral (mature) T-cell neoplasm characterized by the presence + of erythroderma, lymphadenopathy, and neoplastic, cerebriform T-lymphocytes + in the blood. Sezary syndrome is an aggressive disease. (WHO, 2001) + termDef: + term: >- + Sezary Syndrome + source: NCIt + cde_id: C3366 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3366" + term_id: C3366 + term_version: 20.05a + +sezary_syndrome: + common: + description: >- + A generalized peripheral (mature) T-cell neoplasm characterized by the presence + of erythroderma, lymphadenopathy, and neoplastic, cerebriform T-lymphocytes + in the blood. Sezary syndrome is an aggressive disease. (WHO, 2001) + termDef: + term: >- + Sezary Syndrome + source: NCIt + cde_id: C3366 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3366" + term_id: C3366 + term_version: 20.05a + +sf3b1: + common: + description: >- + This gene is involved in mRNA splicing. + termDef: + term: >- + SF3B1 Gene + source: NCIt + cde_id: C98284 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98284" + term_id: C98284 + term_version: 20.10d + +sfpq: + common: + description: >- + This gene may be involved in both transcriptional regulation and nuclear RNA + processing. + termDef: + term: >- + SFPQ Gene + source: NCIt + cde_id: C71417 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71417" + term_id: C71417 + term_version: 20.10d + +sfrp4: + common: + description: >- + This gene plays a role in signal transduction, apoptosis and cell proliferation. + termDef: + term: >- + SFRP4 Gene + source: NCIt + cde_id: C24804 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24804" + term_id: C24804 + term_version: 20.10d + +sgk1: + common: + description: >- + This gene plays a role in both protein phosphorylation and cellular stress response. + termDef: + term: >- + SGK1 Gene + source: NCIt + cde_id: C101559 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101559" + term_id: C101559 + term_version: 20.10d + +sh2b3: + common: + description: >- + This gene plays a role in T-cell activation. + termDef: + term: >- + SH2B3 Gene + source: NCIt + cde_id: C102802 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102802" + term_id: C102802 + term_version: 20.10d + +sh3gl1: + common: + description: >- + This gene may be involved in endocytosis. + termDef: + term: >- + SH3GL1 Gene + source: NCIt + cde_id: C97788 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97788" + term_id: C97788 + term_version: 20.10d + +shenqi_fuzheng_injection_sq001: + common: + description: >- + An injectable formulation composed of the two Chinese medicinal herbs Radix + astragali, the root of astragalus membranaceus (huangqi) and Radix codonopsis, + the root of Codonopsis pilosula (dangshen), with potential antineoplastic adjuvant + and chemoprotective activities that may prevent cancer-related fatigue. Although + the exact mechanisms by which shenqi fuzheng injection (SFI) have yet to be + fully elucidated, the herbs may improve tumor response and/or reduce the toxicity + of certain chemotherapeutics when administered together. It may also alleviate + chemotherapy-associated immunosuppression. + termDef: + term: >- + Shenqi Fuzheng Injection SQ001 + source: NCIt + cde_id: C171384 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171384" + term_id: C171384 + term_version: 20.10d + +shhactivated: + common: + description: >- + A molecular subtype of medulloblastoma associated with activation of the sonic + hedgehog (SHH) pathway. TP53 mutations may be present or absent. Patients in + this group are young children and adults. Overall survival is variable and depends + on the presence or absence of metastatic disease, histology, and the age at + diagnosis. + termDef: + term: >- + Medulloblastoma, SHH-Activated + source: NCIt + cde_id: C129441 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129441" + term_id: C129441 + term_version: 20.05a + +shp2_inhibitor_rly1971: + common: + description: >- + An orally bioavailable inhibitor of protein tyrosine phosphatase (PTP) non-receptor + type 11 (SHP2; Src homology region 2 domain phosphatase; PTPN11), with potential + antineoplastic activity. Upon oral administration, SHP2 inhibitor RLY-1971 targets, + binds to and inhibits the activity of SHP2. This prevents SHP2-mediated signaling, + inhibits MAPK signaling and prevents growth of SHP2-expressing tumor cells. + SHP2, an oncoprotein overexpressed in a variety of cancer cell types, regulates + cell survival, differentiation and proliferation through activation of the Ras-Raf-MEK-ERK + signaling pathway. The Ras-MAPK pathway is often hyperactivated in cancer cells + due to specific mutations and rearrangements and are dependent on SHP2 for their + oncogenic signaling. SHP2 also regulates programmed cell death 1 (PD-1)-mediated + signal transduction and is involved in immune checkpoint modulation. + termDef: + term: >- + SHP2 Inhibitor RLY-1971 + source: NCIt + cde_id: C172988 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172988" + term_id: C172988 + term_version: 20.10d + +shtn1: + common: + description: >- + This gene is involved in neuronal polarization. + termDef: + term: >- + SHTN1 Gene + source: NCIt + cde_id: C122906 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122906" + term_id: C122906 + term_version: 20.10d + +sibling: + common: + description: >- + A person's brother or sister. + termDef: + term: >- + Sibling + source: NCIt + cde_id: C25204 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25204" + term_id: C25204 + term_version: 19.12e + +sierra_leone: + common: + description: >- + A country in western Africa, bordering the North Atlantic Ocean, between Guinea + and Liberia. + termDef: + term: >- + Sierra Leone + source: NCIt + cde_id: C17130 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17130" + term_id: C17130 + term_version: 19.12e + +sigmoid_colon: + common: + description: >- + The portion of the colon that connects to the descending colon above and the + rectum below. + termDef: + term: >- + Sigmoid Colon + source: NCIt + cde_id: C12384 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12384" + term_id: C12384 + term_version: 20.05a + +signet_ring_cell_adenocarcinoma: + common: + description: >- + A usually aggressive, poorly differentiated invasive adenocarcinoma characterized + by the presence of malignant glandular cells in which the nucleus is pressed + to one side by the presence of intracytoplasmic mucus. It may arise from the + stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, + pancreas, lung, bladder, breast, and prostate gland. + termDef: + term: >- + Signet Ring Cell Carcinoma + source: NCIt + cde_id: C3774 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3774" + term_id: C3774 + term_version: 20.05a + +signet_ring_cell_carcinoma: + common: + description: >- + A usually aggressive, poorly differentiated invasive adenocarcinoma characterized + by the presence of malignant glandular cells in which the nucleus is pressed + to one side by the presence of intracytoplasmic mucus. It may arise from the + stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, + pancreas, lung, bladder, breast, and prostate gland. + termDef: + term: >- + Signet Ring Cell Carcinoma + source: NCIt + cde_id: C3774 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3774" + term_id: C3774 + term_version: 20.05a + +simlukafusp_alfa: + common: + description: >- + A recombinant fusion protein comprised of a human monoclonal antibody directed + against fibroblast activation protein-alpha (FAP) linked to an engineered, variant + form of interleukin-2 (IL-2v), with potential immunostimulating and antineoplastic + activities. Upon administration of simlukafusp alfa, the monoclonal antibody + moiety recognizes and binds to FAP, thereby concentrating IL-2 in FAP-expressing + tumor tissue. Subsequently, the IL-2 moiety of this fusion protein may stimulate + a local immune response and activate natural killer (NK) cells and cytotoxic + T-cells. FAP is a cell surface protein that is expressed on a wide variety of + cancer cells. IL-2v cannot bind to IL-2 receptor-alpha (CD25, IL2Ra) and does + not activate regulatory T-cells (Tregs). + termDef: + term: >- + Simlukafusp Alfa + source: NCIt + cde_id: C129383 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129383" + term_id: C129383 + term_version: 20.10d + +simmitinib: + common: + description: >- + An orally bioavailable inhibitor of numerous tyrosine kinases (TKs) including + fibroblast growth factor receptor (FGFR), vascular endothelial growth factor + receptor type 2 (VEGFR2; KDR), and colony stimulating factor 1 receptor (CSF1R; + CSF-1R), with potential antiangiogenic and antineoplastic activities. Upon oral + administration, simmitinib binds to and inhibits the activities of these TKs, + thereby preventing both the activation of downstream signaling pathways and + the proliferation of tumor cells overexpressing these TKs. FGFR, VEGFR2, and + CSF1R are upregulated in a variety of cancer cell types and play key roles in + tumor cell proliferation, angiogenesis, and metastasis. + termDef: + term: >- + Simmitinib + source: NCIt + cde_id: C170763 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C170763" + term_id: C170763 + term_version: 20.10d + +simurosertib: + common: + description: >- + An orally bioavailable inhibitor of cell division cycle 7 (cell division cycle + 7-related protein kinase; CDC7), with potential antineoplastic activity. Upon + administration, simurosertib binds to and inhibits CDC7; this prevents the initiation + of DNA replication during mitosis, which causes cell cycle arrest and induces + apoptosis. This inhibits cell growth in CDC7-overexpressing tumor cells. CDC7, + a serine/threonine kinase and cell division cycle protein, is overexpressed + in a variety of cancers and plays a key role in the activation of DNA replication + and the regulation of cell cycle progression. + termDef: + term: >- + Simurosertib + source: NCIt + cde_id: C126641 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126641" + term_id: C126641 + term_version: 20.10d + +singapore: + common: + description: >- + A country in southeastern Asia, comprised of the southern tip of the Malaysian + peninsula and nearby islands between Malaysia and Indonesia. + termDef: + term: >- + Singapore + source: NCIt + cde_id: C17134 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17134" + term_id: C17134 + term_version: 19.12e + +sinonasal_papilloma_exophytic: + common: + description: >- + A benign neoplasm that arises from the ciliated respiratory mucosa that lines + the nasal cavity and paranasal sinuses. It is classified as inverted papilloma, + oncocytic papilloma, and exophytic papilloma. Clinical manifestations include + nasal obstruction, epistaxis, and anosmia. + termDef: + term: >- + Sinonasal Schneiderian Papilloma + source: NCIt + cde_id: C4117 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4117" + term_id: C4117 + term_version: 20.05a + +sinonasal_papilloma_fungiform: + common: + description: >- + A benign neoplasm that arises from the ciliated respiratory mucosa that lines + the nasal cavity and paranasal sinuses. It is classified as inverted papilloma, + oncocytic papilloma, and exophytic papilloma. Clinical manifestations include + nasal obstruction, epistaxis, and anosmia. + termDef: + term: >- + Sinonasal Schneiderian Papilloma + source: NCIt + cde_id: C4117 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4117" + term_id: C4117 + term_version: 20.05a + +sinonasal_papilloma_nos: + common: + description: >- + A benign neoplasm that arises from the ciliated respiratory mucosa that lines + the nasal cavity and paranasal sinuses. It is classified as inverted papilloma, + oncocytic papilloma, and exophytic papilloma. Clinical manifestations include + nasal obstruction, epistaxis, and anosmia. + termDef: + term: >- + Sinonasal Schneiderian Papilloma + source: NCIt + cde_id: C4117 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4117" + term_id: C4117 + term_version: 20.05a + +siremadlin: + common: + description: >- + An orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential + antineoplastic activity. Siremadlin inhibits the binding of the HDM2 protein + to the transcriptional activation domain of the tumor suppressor protein p53. + By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation + of p53 is inhibited, which may result in the restoration of both p53 signaling + and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein + and negative regulator of the p53 pathway, is often overexpressed in cancer + cells and has been implicated in cancer cell proliferation and survival. + termDef: + term: >- + Siremadlin + source: NCIt + cde_id: C116325 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C116325" + term_id: C116325 + term_version: 20.10d + +sirpa: + common: + description: >- + This gene is involved in cellular signal transduction and tyrosine kinase-coupled + signaling processes. + termDef: + term: >- + SIRPA Gene + source: NCIt + cde_id: C24710 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24710" + term_id: C24710 + term_version: 20.10d + +sirpa41bbl_fusion_protein_dsp107: + common: + description: >- + A bi-functional, trimeric, fusion protein consisting of the extracellular domains + (ECDs) of human signal-regulatory protein alpha (SIRPalpha; SIRPa; CD172a) fused + to a 4-1BB ligand (4-1BBL), with potential immune checkpoint inhibitory, immunostimulating + and antineoplastic activities. Upon administration, the SIRPa-4-1BBL fusion + protein DSP107 selectively targets and binds to both CD47 expressed on tumor + cells and 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; + TNFRSF9) expressed on T-cells and natural killer (NK) cells. Binding to CD47 + blocks the interaction of CD47 with endogenous SIRPa, a cell surface protein + expressed on macrophages. This prevents CD47/SIRPa-mediated signaling and abrogates + the CD47/SIRPa-mediated inhibition of macrophage activation and phagocytosis + of cancer cells. This induces pro-phagocytic signaling mediated by the binding + of calreticulin (CRT), which is specifically expressed on the surface of tumor + cells, to low-density lipoprotein (LDL) receptor-related protein-1 (LRP-1), + which is expressed on macrophages, and results in macrophage activation and + the specific phagocytosis of tumor cells. The binding of 4-1BBL to 4-1BB activates + 4-1BB-mediated signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, + cytokine production and promotes a CTL-mediated anti-tumor immune response as + well as NK-mediated tumor cell killing. The crosslinking specifically enables + the activation of 4-1BB-mediated signaling in T-cells and NK cells in the tumor + microenvironment (TME), allowing targeted immune responses in the TME. CD47, + also called integrin-associated protein (IAP), is a tumor-associated antigen + (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed + on the surface of a variety of cancer cells. Expression of CD47, and its interaction + with SIRPa, leads to the inhibition of macrophage activation and protects cancer + cells from phagocytosis, thereby allowing cancer cells to proliferate. 4-1BB, + a surface glycoprotein of the tumor necrosis factor receptor superfamily, is + an inducible costimulatory receptor that plays a key role in T-cell proliferation, + survival and cytolytic activity. + termDef: + term: >- + SIRPa-4-1BBL Fusion Protein DSP107 + source: NCIt + cde_id: C174171 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174171" + term_id: C174171 + term_version: 20.10d + +sirpafccd40l_fusion_protein_sl172154: + common: + description: >- + A bi-functional fusion protein consisting of the extracellular domains (ECDs) + of human signal-regulatory protein alpha (SIRPalpha; SIRPa; CD172a) and CD40 + ligand (CD40L; CD154; TRAP; TNFSF5) linked via a human Fc domain, with potential + immune checkpoint inhibitory and antineoplastic activities. Upon administration, + the SIRPa-Fc-CD40L fusion protein SL-172154 selectively targets and binds to + both CD47 expressed on tumor cells and CD40, a cell surface receptor that belongs + to the tumor necrosis factor (TNF) receptor family, expressed on antigen-presenting + cells (APCs). Binding to CD47 blocks the interaction of CD47 with endogenous + SIRPa, a cell surface protein expressed on macrophages. This prevents CD47/SIRPa-mediated + signaling and abrogates the CD47/SIRPa-mediated inhibition of macrophage activation + and phagocytosis of cancer cells. This induces pro-phagocytic signaling mediated + by the binding of calreticulin (CRT), which is specifically expressed on the + surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein-1 + (LRP-1), which is expressed on macrophages, and results in macrophage activation + and the specific phagocytosis of tumor cells. The binding of CD40L to CD40 activates + CD40, increases CD40-mediated signaling and induces proliferation and activation + of B-lymphocytes, shifts the induction of suppressive macrophages towards immunostimulatory + macrophages, activates monocyte-derived dendritic cells (moDCs), and leads to + the secretion of inflammatory cytokines. This activates the immune system to + induce the proliferation and activation of cytotoxic T-lymphocytes (CTLs) against + tumor cells. The crosslinking specifically enhances antigen presentation to + CD8+ and CD4+ T lymphocytes and tumor cell phagocytosis by the APC. CD47, also + called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) + expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed + on the surface of a variety of cancer cells. Expression of CD47, and its interaction + with SIRPa, leads to the inhibition of macrophage activation and protects cancer + cells from phagocytosis, thereby allowing cancer cells to proliferate. + termDef: + term: >- + SIRPa-Fc-CD40L Fusion Protein SL-172154 + source: NCIt + cde_id: C173706 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173706" + term_id: C173706 + term_version: 20.10d + +sister: + common: + description: >- + A female sibling. + termDef: + term: >- + Sister + source: NCIt + cde_id: C25680 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25680" + term_id: C25680 + term_version: 19.12e + +sisterinlaw: + common: + description: >- + A sister by marriage. + termDef: + term: >- + Sister-in-law + source: NCIt + cde_id: C71407 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71407" + term_id: C71407 + term_version: 19.12e + +six_weeks_or_more: + common: + description: >- + The text term used to describe a time period of six calendar weeks or longer. + termDef: + term: >- + Six Weeks or More + source: NCIt + cde_id: + cde_version: + term_url: + +ski: + common: + description: >- + This gene is involved in transcriptional regulation and is involved in cellular + signal transduction. + termDef: + term: >- + SKI Gene + source: NCIt + cde_id: C69184 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C69184" + term_id: C69184 + term_version: 20.10d + +skin: + common: + description: >- + An organ that constitutes the external surface of the body. It consists of the + epidermis, dermis, and skin appendages. + termDef: + term: >- + Skin + source: NCIt + cde_id: C12470 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12470" + term_id: C12470 + term_version: 20.05a + +skin_appendage_adenoma: + common: + description: >- + A benign epithelial neoplasm arising from the sebaceous or sweat glands. Representative + examples include sebaceous adenoma, tubular apocrine adenoma, and hidradenoma. + termDef: + term: >- + Skin Appendage Adenoma + source: NCIt + cde_id: C7580 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7580" + term_id: C7580 + term_version: 20.05a + +skin_appendage_carcinoma: + common: + description: >- + A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. + Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine + carcinoma, and pilomatrical carcinoma. + termDef: + term: >- + Adnexal Carcinoma + source: NCIt + cde_id: C3775 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3775" + term_id: C3775 + term_version: 20.05a + +skin_appendage_tumor_benign: + common: + description: >- + A non-metastasizing neoplasm that arises from the hair follicles, sebaceous + glands, or sweat glands. Representative examples include cylindroma, hidrocystoma, + hidradenoma, and sebaceoma. + termDef: + term: >- + Benign Skin Appendage Neoplasm + source: NCIt + cde_id: C4615 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4615" + term_id: C4615 + term_version: 20.05a + +skin_cancer: + common: + description: >- + A primary or metastatic malignant neoplasm involving the skin. Primary malignant + skin neoplasms most often are carcinomas (either basal cell or squamous cell + carcinomas) or melanomas. Metastatic malignant neoplasms to the skin include + carcinomas and lymphomas. + termDef: + term: >- + Malignant Skin Neoplasm + source: NCIt + cde_id: C2920 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2920" + term_id: C2920 + term_version: 19.12e + +skin_nos: + common: + description: >- + An organ that constitutes the external surface of the body. It consists of the + epidermis, dermis, and skin appendages. + termDef: + term: >- + Skin + source: NCIt + cde_id: C12470 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12470" + term_id: C12470 + term_version: 20.05a + +skin_of_lip_nos: + common: + description: >- + The skin portion of the lip that contains hair. + termDef: + term: >- + Skin of the Lip + source: NCIt + cde_id: C12291 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12291" + term_id: C12291 + term_version: 20.05a + +skin_of_lower_limb_and_hip: + common: + description: >- + The integumentary covering of the lower limb and hip region. + termDef: + term: >- + Skin of the Lower Limb and Hip + source: NCIt + cde_id: C12297 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12297" + term_id: C12297 + term_version: 20.05a + +skin_of_other_and_unspecified_parts_of_face: + common: + description: >- + The integumentary covering of the face. + termDef: + term: >- + Skin of the Face + source: NCIt + cde_id: C33561 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33561" + term_id: C33561 + term_version: 20.05a + +skin_of_scalp_and_neck: + common: + description: >- + The integumentary covering of the scalp and neck. + termDef: + term: >- + Skin of the Scalp and Neck + source: NCIt + cde_id: C12294 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12294" + term_id: C12294 + term_version: 20.05a + +skin_of_trunk: + common: + description: >- + The skin or integument surrounding the trunk of the body. + termDef: + term: >- + Skin of the Trunk + source: NCIt + cde_id: C12295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12295" + term_id: C12295 + term_version: 20.05a + +skin_of_upper_limb_and_shoulder: + common: + description: >- + The integumentary covering of the upper limb and shoulder region. + termDef: + term: >- + Skin of the Upper Limb and Shoulder + source: NCIt + cde_id: C12296 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12296" + term_id: C12296 + term_version: 20.05a + +skinassociated_lymphoid_tissue_lymphoma: + common: + description: >- + A low-grade, extranodal marginal zone B-cell lymphoma of the mucosa-associated + lymphoid tissue that arises from the skin. It usually presents with multifocal + papular or nodular lesions in the arms or trunk. It rarely disseminates to + internal organs or progresses to high grade lymphoma. + termDef: + term: >- + Primary Cutaneous Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue + source: NCIt + cde_id: C7230 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7230" + term_id: C7230 + term_version: 20.05a + +slc34a2: + common: + description: >- + This gene plays a role in phosphate transport. + termDef: + term: >- + SLC34A2 Gene + source: NCIt + cde_id: C101434 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101434" + term_id: C101434 + term_version: 20.10d + +slc45a3: + common: + description: >- + This gene plays a role in transmembrane transport. + termDef: + term: >- + SLC45A3 Gene + source: NCIt + cde_id: C97791 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97791" + term_id: C97791 + term_version: 20.10d + +slovakia: + common: + description: >- + A country in central Europe, south of Poland and north of Hungary. + termDef: + term: >- + Slovakia + source: NCIt + cde_id: C17669 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17669" + term_id: C17669 + term_version: 19.12e + +slovenia: + common: + description: >- + A country in central Europe, bordering the Adriatic Sea, between Austria and + Croatia. + termDef: + term: >- + Slovenia + source: NCIt + cde_id: C17138 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17138" + term_id: C17138 + term_version: 19.12e + +smad2: + common: + description: >- + This gene plays a role in signal transduction and repression of transcription. + termDef: + term: >- + SMAD2 Gene + source: NCIt + cde_id: C24566 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24566" + term_id: C24566 + term_version: 20.10d + +smad3: + common: + description: >- + This gene is involved in signal transduction and apoptosis. It also plays a + role in the regulation of both steroid synthesis and T-cell response. + termDef: + term: >- + SMAD3 Gene + source: NCIt + cde_id: C18504 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18504" + term_id: C18504 + term_version: 20.10d + +smad4: + common: + description: >- + This gene plays a role in signal transduction and transcriptional activation. + It is also involved in suppression of angiogenesis. + termDef: + term: >- + SMAD4 Gene + source: NCIt + cde_id: C18258 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18258" + term_id: C18258 + term_version: 20.10d + +small_cell_carcinoma_fusiform_cell: + common: + description: >- + A neuroendocrine carcinoma composed of malignant fusiform small cells. + termDef: + term: >- + Small Cell Carcinoma, Fusiform Cell Type + source: NCIt + cde_id: C27092 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27092" + term_id: C27092 + term_version: 20.05a + +small_cell_carcinoma_hypercalcemic_type: + common: + description: >- + An undifferentiated small cell carcinoma that arises from the ovary and is associated + with hypercalcemia. Electron microscopic studies show neurosecretory granules + are either absent or, when present, are in small numbers. + termDef: + term: >- + Ovarian Small Cell Carcinoma, Hypercalcemic Type + source: NCIt + cde_id: C40439 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40439" + term_id: C40439 + term_version: 20.05a + +small_cell_carcinoma_intermediate_cell: + common: + description: >- + A neuroendocrine carcinoma composed of malignant small cells of intermediate + shape. + termDef: + term: >- + Small Cell Intermediate Cell Carcinoma + source: NCIt + cde_id: C4099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4099" + term_id: C4099 + term_version: 20.05a + +small_cell_carcinoma_nos: + common: + description: >- + A neuroendocrine carcinoma composed of small malignant cells which are often + said to resemble "oat cells" under the microscope. Small cell carcinoma most + often affects the lungs. Clinically, this is often a rapidly growing cancer + that spreads to distant sites early. + termDef: + term: >- + Small Cell Carcinoma + source: NCIt + cde_id: C3915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3915" + term_id: C3915 + term_version: 20.05a + +small_cell_carcinoma_pulmonary_type: + common: + description: >- + An aggressive small cell neuroendocrine carcinoma that arises from the ovary. Morphologically, + it resembles the small cell carcinoma that arises from the lung. + termDef: + term: >- + Ovarian Small Cell Carcinoma, Pulmonary-Type + source: NCIt + cde_id: C40440 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40440" + term_id: C40440 + term_version: 20.05a + +small_cell_neuroendocrine_carcinoma: + common: + description: >- + A neuroendocrine carcinoma composed of small malignant cells which are often + said to resemble "oat cells" under the microscope. Small cell carcinoma most + often affects the lungs. Clinically, this is often a rapidly growing cancer + that spreads to distant sites early. + termDef: + term: >- + Small Cell Carcinoma + source: NCIt + cde_id: C3915 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3915" + term_id: C3915 + term_version: 20.05a + +small_cell_osteosarcoma: + common: + description: >- + An osteosarcoma usually arising from the metaphysis of long bones. It is characterized + by the presence of small cells and osteoid production. The prognosis is usually + unfavorable. + termDef: + term: >- + Small Cell Osteosarcoma + source: NCIt + cde_id: C4023 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4023" + term_id: C4023 + term_version: 20.05a + +small_cell_sarcoma: + common: + description: >- + A sarcoma characterized by the presence of small round or elongated malignant + cells with a small amount of cytoplasm. + termDef: + term: >- + Small Cell Sarcoma + source: NCIt + cde_id: C3746 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3746" + term_id: C3746 + term_version: 20.05a + +small_intestine: + common: + description: >- + The section of the intestines between the pylorus and cecum. The small intestine + is approximately 20 feet long and consists of the duodenum, the jejunum, and + the ileum. Its main function is to absorb nutrients from food as the food is + transported to the large intestine. + termDef: + term: >- + Small Intestine + source: NCIt + cde_id: C12386 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12386" + term_id: C12386 + term_version: 20.05a + +small_intestine_nos: + common: + description: >- + The section of the intestines between the pylorus and cecum. The small intestine + is approximately 20 feet long and consists of the duodenum, the jejunum, and + the ileum. Its main function is to absorb nutrients from food as the food is + transported to the large intestine. + termDef: + term: >- + Small Intestine + source: NCIt + cde_id: C12386 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12386" + term_id: C12386 + term_version: 20.05a + +smarca4: + common: + description: >- + This gene plays a role in chromatin remodeling, cell cycle control and regulation + of transcription. + termDef: + term: >- + SMARCA4 Gene + source: NCIt + cde_id: C19878 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19878" + term_id: C19878 + term_version: 20.10d + +smarcb1: + common: + description: >- + This gene plays a role in chromatin remodeling and regulation of transcription. + termDef: + term: >- + SMARCB1 Gene + source: NCIt + cde_id: C18394 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18394" + term_id: C18394 + term_version: 20.10d + +smarcd1: + common: + description: >- + This gene plays a role in chromatin remodeling and regulation of transcription. + termDef: + term: >- + SMARCD1 Gene + source: NCIt + cde_id: C19875 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19875" + term_id: C19875 + term_version: 20.10d + +smarce1: + common: + description: >- + This gene is involved in chromatin remodeling and regulation of transcription. + termDef: + term: >- + SMARCE1 Gene + source: NCIt + cde_id: C19874 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19874" + term_id: C19874 + term_version: 20.10d + +smc1a: + common: + description: >- + This gene is involved in maintenance of sister chromatid cohesion during mitosis. + termDef: + term: >- + SMC1A Gene + source: NCIt + cde_id: C75406 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75406" + term_id: C75406 + term_version: 20.10d + +smo: + common: + description: >- + This gene plays a role in G protein-coupled receptor signal transduction and + sonic hedgehog pathway activation. + termDef: + term: >- + SMO Gene + source: NCIt + cde_id: C24817 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24817" + term_id: C24817 + term_version: 20.10d + +smoke_exposure_nos: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced when materials undergo combustion or thermal decomposition. + termDef: + term: >- + Smoke Exposure + source: NCIt + cde_id: C164057 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164057" + term_id: C164057 + term_version: 19.12e + +smokehouse_smoke: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced during indoor smoke curing of food products. + termDef: + term: >- + Smokehouse Smoke Exposure + source: NCIt + cde_id: C164095 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164095" + term_id: C164095 + term_version: 19.12e + +smokeless_tobacco: + common: + description: >- + Tobacco that is not smoked but used in another form such as chewing tobacco + or snuff. + termDef: + term: >- + Smokeless Tobacco + source: NCIt + cde_id: C892 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C892" + term_id: C892 + term_version: 19.12e + +smooth_muscle_tumor_nos: + common: + description: >- + A benign or malignant myomatous neoplasm arising from smooth muscle. + termDef: + term: >- + Smooth Muscle Neoplasm + source: NCIt + cde_id: C3751 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3751" + term_id: C3751 + term_version: 20.05a + +smooth_muscle_tumor_of_uncertain_malignant_potential: + common: + description: >- + A benign or malignant myomatous neoplasm arising from smooth muscle. + termDef: + term: >- + Smooth Muscle Neoplasm + source: NCIt + cde_id: C3751 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3751" + term_id: C3751 + term_version: 20.05a + +snd1: + common: + description: >- + This gene plays a role in both transcriptional regulation and RNA interference. + termDef: + term: >- + SND1 Gene + source: NCIt + cde_id: C96331 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96331" + term_id: C96331 + term_version: 20.10d + +snx29: + common: + description: >- + This gene may be involved in signal transduction or lipid binding. + termDef: + term: >- + SNX29 Gene + source: NCIt + cde_id: C97764 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97764" + term_id: C97764 + term_version: 20.10d + +social_security_death_index: + common: + description: >- + A publically-accessible database derived from the Social Security Administration's + (SSA) Death Master File Extract. It includes a listing of the vital statistics + of a majority of decedents reported to the SSA since 1962. + termDef: + term: >- + Social Security Death Index + source: NCIt + cde_id: C107424 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107424" + term_id: C107424 + term_version: 19.12e + +socs1: + common: + description: >- + This gene is involved in the attenuation of cytokine signaling. + termDef: + term: >- + SOCS1 Gene + source: NCIt + cde_id: C97794 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97794" + term_id: C97794 + term_version: 20.10d + +soft_palate_nos: + common: + description: >- + The part of the pharynx between the soft palate and the upper portion of the + epiglottis. + termDef: + term: >- + Oropharynx + source: NCIt + cde_id: C12762 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12762" + term_id: C12762 + term_version: 20.05a + +soft_tissue: + common: + description: >- + A general term comprising tissue that is not hardened or calcified; including + muscle, fat, blood vessels, nerves, tendons, ligaments and fascia. + termDef: + term: >- + Soft Tissue + source: NCIt + cde_id: C12471 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12471" + term_id: C12471 + term_version: 20.05a + +soft_tissue_perineurioma: + common: + description: >- + A perineurioma not associated with a nerve, arising from the soft tissues. + termDef: + term: >- + Soft Tissue Perineurioma + source: NCIt + cde_id: C6912 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6912" + term_id: C6912 + term_version: 20.05a + +soft_tissue_sarcoma: + common: + description: >- + A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, + fibrous tissue, or other supportive tissues excluding the bones. + termDef: + term: >- + Soft Tissue Sarcoma + source: NCIt + cde_id: C9306 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9306" + term_id: C9306 + term_version: 20.05a + +soft_tissue_tumor_benign: + common: + description: >- + A non-metastasizing neoplasm that arises from the soft tissue. + termDef: + term: >- + Benign Soft Tissue Neoplasm + source: NCIt + cde_id: C4242 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4242" + term_id: C4242 + term_version: 20.05a + +soft_tissue_tumor_malignant: + common: + description: >- + A malignant neoplasm arising exclusively from the soft tissues. + termDef: + term: >- + Malignant Soft Tissue Neoplasm + source: NCIt + cde_id: C4867 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4867" + term_id: C4867 + term_version: 20.05a + +solid: + common: + description: >- + A microscopic finding indicating that the neoplastic cells are arranged in solid + sheets in a tumor sample. + termDef: + term: >- + Solid Growth Pattern + source: NCIt + cde_id: C36182 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36182" + term_id: C36182 + term_version: 20.10d + +solid_and_cystic_tumor: + common: + description: >- + A benign, malignant, or borderline epithelial neoplasm characterized by the + presence of papillary mucinous, serous, or clear cell structures and cystic + structures. + termDef: + term: >- + Papillary Cystic Neoplasm + source: NCIt + cde_id: C4179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4179" + term_id: C4179 + term_version: 20.05a + +solid_and_papillary_epithelial_neoplasm: + common: + description: >- + A benign, malignant, or borderline epithelial neoplasm characterized by the + presence of papillary mucinous, serous, or clear cell structures and cystic + structures. + termDef: + term: >- + Papillary Cystic Neoplasm + source: NCIt + cde_id: C4179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4179" + term_id: C4179 + term_version: 20.05a + +solid_carcinoma_nos: + common: + description: >- + A carcinoma morphologically characterized by the presence of solid sheets of + malignant epithelial cells in tissues. + termDef: + term: >- + Solid Carcinoma + source: NCIt + cde_id: C4137 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4137" + term_id: C4137 + term_version: 20.05a + +solid_papillary_carcinoma_in_situ: + common: + description: >- + A well circumscribed, low grade neoplasm that arises from the breast. It is + characterized by the presence of sheets of malignant epithelial cells that are + supported by fibrovascular structures. When there is an invasive component + present, it is usually a mucinous carcinoma. + termDef: + term: >- + Solid Papillary Breast Carcinoma + source: NCIt + cde_id: C6870 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6870" + term_id: C6870 + term_version: 20.05a + +solid_pseudopapillary_tumor: + common: + description: >- + A benign, malignant, or borderline epithelial neoplasm characterized by the + presence of papillary mucinous, serous, or clear cell structures and cystic + structures. + termDef: + term: >- + Papillary Cystic Neoplasm + source: NCIt + cde_id: C4179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4179" + term_id: C4179 + term_version: 20.05a + +solid_teratoma: + common: + description: >- + A non-seminomatous germ cell tumor characterized by the presence of various + tissues which correspond to the different germinal layers (endoderm, mesoderm, + and ectoderm). It occurs in the testis, ovary, and extragonadal sites including + central nervous system, mediastinum, lung, and stomach. According to the level + of differentiation of the tissues which comprise the tumor, teratomas are classified + as benign (grade 0 or 1), immature (grade 2), and malignant (grade 3). Grade + 0 teratomas contain only mature elements; grade 1 teratomas have a limited degree + of immaturity; grade 2 teratomas have a more extensive degree of immaturity; + grade 3 teratomas are composed exclusively of immature tissues. The prognosis + depends on patient age, tumor size and grade, and stage. + termDef: + term: >- + Teratoma + source: NCIt + cde_id: C3403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3403" + term_id: C3403 + term_version: 20.05a + +solitary_fibrous_tumor: + common: + description: >- + A localized neoplasm of probable fibroblastic derivation. It is characterized + by the presence of round to spindle-shaped cells, hylanized stroma formation, + thin-walled branching blood vessels, and thin bands of collagen. + termDef: + term: >- + Solitary Fibrous Tumor + source: NCIt + cde_id: C7634 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7634" + term_id: C7634 + term_version: 20.05a + +solitary_fibrous_tumor_malignant: + common: + description: >- + A malignant neoplasm of probable fibroblastic derivation. It is characterized + by the presence of atypical round to spindle-shaped cells, increased cellularity, + necrotic change and high mitotic activity. + termDef: + term: >- + Malignant Solitary Fibrous Tumor + source: NCIt + cde_id: C6894 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6894" + term_id: C6894 + term_version: 20.05a + +solitary_fibrous_tumorhemangiopericytoma_grade_1_cns: + common: + description: >- + A solitary fibrous tumor/hemangiopericytoma that arises from the central nervous + system. It corresponds most often to the collagenous and low cellularity spindle + cell tumor which was diagnosed as central nervous system solitary fibrous tumor + in the past. + termDef: + term: >- + Central Nervous System Solitary Fibrous Tumor/Hemangiopericytoma, Grade 1 + source: NCIt + cde_id: C129530 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129530" + term_id: C129530 + term_version: 20.05a + +solitary_fibrous_tumorhemangiopericytoma_grade_2_cns: + common: + description: >- + A solitary fibrous tumor/hemangiopericytoma that arises from the central nervous + system. It corresponds to the more cellular, less collagenous tumor with plump + cells and staghorn vasculature which was diagnosed as central nervous system + hemangiopericytoma in the past. + termDef: + term: >- + Central Nervous System Solitary Fibrous Tumor/Hemangiopericytoma, Grade 2 + source: NCIt + cde_id: C129528 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129528" + term_id: C129528 + term_version: 20.05a + +solitary_fibrous_tumorhemangiopericytoma_grade_3_cns: + common: + description: >- + A solitary fibrous tumor/hemangiopericytoma that arises from the central nervous + system. It most often corresponds to the tumor previously diagnosed as anaplastic + hemangiopericytoma. + termDef: + term: >- + Central Nervous System Solitary Fibrous Tumor/Hemangiopericytoma, Grade 3 + source: NCIt + cde_id: C129527 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129527" + term_id: C129527 + term_version: 20.05a + +solitary_mastocytoma_of_skin: + common: + description: >- + Solitary Mastocytoma of the Skin + termDef: + term: >- + Solitary Mastocytoma of the Skin + source: NCIt + cde_id: C7138 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7138" + term_id: C7138 + term_version: 20.05a + +solitary_myeloma: + common: + description: >- + A localized clonal (malignant) plasma cell infiltrate either in the bony skeleton + or soft tissue without peripheral blood involvement. + termDef: + term: >- + Solitary Plasmacytoma + source: NCIt + cde_id: C6932 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6932" + term_id: C6932 + term_version: 20.05a + +solitary_plasmacytoma: + common: + description: >- + A localized clonal (malignant) plasma cell infiltrate either in the bony skeleton + or soft tissue without peripheral blood involvement. + termDef: + term: >- + Solitary Plasmacytoma + source: NCIt + cde_id: C6932 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6932" + term_id: C6932 + term_version: 20.05a + +solomon_islands: + common: + description: >- + A group of islands in the South Pacific Ocean, east of Papua New Guinea. + termDef: + term: >- + Solomon Islands + source: NCIt + cde_id: C17148 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17148" + term_id: C17148 + term_version: 19.12e + +somalia: + common: + description: >- + A country in eastern Africa, bordering the Gulf of Aden and the Indian Ocean, + east of Ethiopia. + termDef: + term: >- + Somalia + source: NCIt + cde_id: C17149 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17149" + term_id: C17149 + term_version: 19.12e + +somatic: + common: + description: >- + Any mutation with an origin in cells that are not destined to become gametes. + As a consequence, such mutations are not transmitted to progeny, though they + will be transmitted during any mitosis within the individual. Somatic mutations + may contribute to a broad variety of pathologies including cancer. + termDef: + term: >- + Somatic Mutation + source: NCIt + cde_id: C18060 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18060" + term_id: C18060 + term_version: 20.10d + +somatostatin_cell_tumor_malignant: + common: + description: >- + A malignant neuroendocrine tumor arising from delta cells which produce somatostatin. + It displays vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Somatostatinoma + source: NCIt + cde_id: C65190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65190" + term_id: C65190 + term_version: 20.05a + +somatostatin_cell_tumor_nos: + common: + description: >- + A rare, usually malignant neuroendocrine tumor arizing from delta cells. This + neoplasm produces large amounts of somatostatin, which may result in a syndrome + characterized by diarrhea, steatorrhea, weight loss, and gastric hyposecretion. + Sixty percent are found in the pancreas and 40% in the duodenum or jejunum. + The peak incidence occurs between 40 and 60 years of age; women are affected + more than men by 2:1. + termDef: + term: >- + Somatostatin-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C3379 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3379" + term_id: C3379 + term_version: 20.05a + +somatostatinoma_malignant: + common: + description: >- + A malignant neuroendocrine tumor arising from delta cells which produce somatostatin. + It displays vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Somatostatinoma + source: NCIt + cde_id: C65190 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65190" + term_id: C65190 + term_version: 20.05a + +somatostatinoma_nos: + common: + description: >- + A rare, usually malignant neuroendocrine tumor arizing from delta cells. This + neoplasm produces large amounts of somatostatin, which may result in a syndrome + characterized by diarrhea, steatorrhea, weight loss, and gastric hyposecretion. + Sixty percent are found in the pancreas and 40% in the duodenum or jejunum. + The peak incidence occurs between 40 and 60 years of age; women are affected + more than men by 2:1. + termDef: + term: >- + Somatostatin-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C3379 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3379" + term_id: C3379 + term_version: 20.05a + +some_days: + common: + description: >- + A response indicating that an individual experiences or experienced something + on some days. + termDef: + term: >- + Some Days + source: NCIt + cde_id: C131735 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131735" + term_id: C131735 + term_version: 19.12e + +son: + common: + description: >- + A male human offspring. + termDef: + term: >- + Son + source: NCIt + cde_id: C25205 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25205" + term_id: C25205 + term_version: 19.12e + +soninlaw: + common: + description: >- + The husband of your daughter. + termDef: + term: >- + Son-in-law + source: NCIt + cde_id: C71400 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71400" + term_id: C71400 + term_version: 19.12e + +sotigalimab: + common: + description: >- + A humanized monoclonal antibody agonist of the cell surface receptor CD40, with + potential immunostimulatory and antineoplastic activities. Similar to the endogenous + CD40 ligand (CD40L or CD154), sotigalimab binds to CD40 on a variety of immune + cell types. This triggers the cellular proliferation and activation of antigen-presenting + cells (APCs), and activates B-cells, and effector and memory T-cells. This results + in an enhanced immune response against tumor cells. Sotigalimab also binds to + and activates CD40 present on the surfaces of some solid tumor cells, leading + to apoptosis and decreased tumor growth. CD40, a cell surface receptor and member + of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various + immune cells and certain cancer cells; it mediates both indirect tumor cell + killing through the activation of the immune system and direct tumor cell apoptosis. + termDef: + term: >- + Sotigalimab + source: NCIt + cde_id: C123734 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123734" + term_id: C123734 + term_version: 20.10d + +sotorasib: + common: + description: >- + An orally available agent that targets the specific KRAS mutation, p.G12C, with + potential antineoplastic activity. Upon oral administration, sotorasib selectively + targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and + prevents, through an as of yet not elucidated manner, expression of and/or tumor + cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS + p.G12C-expressing tumor cells. The KRAS p.G12C mutation is seen in some tumor + cell types and plays a key role in tumor cell proliferation. + termDef: + term: >- + Sotorasib + source: NCIt + cde_id: C154287 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154287" + term_id: C154287 + term_version: 20.10d + +south_africa: + common: + description: >- + A country in southern Africa, at the southern tip of the continent of Africa. + termDef: + term: >- + South Africa + source: NCIt + cde_id: C17151 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17151" + term_id: C17151 + term_version: 19.12e + +south_korea: + common: + description: >- + A country in eastern Asia, occupying the southern half of the Korean Peninsula, + bordering the Sea of Japan and the Yellow Sea. + termDef: + term: >- + South Korea + source: NCIt + cde_id: C16774 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16774" + term_id: C16774 + term_version: 19.12e + +south_sudan: + common: + description: >- + A country in east central Africa south of Sudan, north of Uganda and Kenya, + and west of Ethiopia. + termDef: + term: >- + South Sudan + source: NCIt + cde_id: C97351 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97351" + term_id: C97351 + term_version: 19.12e + +southern_blotting: + common: + description: >- + A technique for the detection of specific DNA fragments that have been separated + by polyacrylamide-gel electrophoresis, transferred to a nitrocellulose or other + type of paper or nylon membrane, and detected by hybridization and visualization + with a labeled probe. + termDef: + term: >- + Southern Blotting + source: NCIt + cde_id: C16356 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16356" + term_id: C16356 + term_version: 20.10d + +sox2: + common: + description: >- + This gene is involved in embryonic development and in the determination of cell + fate. + termDef: + term: >- + SOX2 Gene + source: NCIt + cde_id: C61136 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61136" + term_id: C61136 + term_version: 20.10d + +spain: + common: + description: >- + A country in southwestern Europe, bordering the Bay of Biscay, Mediterranean + Sea, and North Atlantic Ocean, southwest of France. + termDef: + term: >- + Spain + source: NCIt + cde_id: C17152 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17152" + term_id: C17152 + term_version: 19.12e + +spanlecortemlocel: + common: + description: >- + A preparation of allogeneic umbilical cord blood (UCB)-derived hematopoietic + stem and progenitor cells (HSPCs) expanded in culture with the stimulatory cytokines + stem cell factor (SCF; Kit ligand; mast cell growth factor; MGF), FMS-like tyrosine + kinase 3 ligand (Flt3L), interleukin 6 (IL-6), and thrombopoietin, in the presence + of an aryl hydrocarbon receptor (AHR) antagonist LHD221 (StemRegenin-1; SR-1), + with potential to improve hematopoietic recovery following myeloablative conditioning. + Upon administration of Spanlecortemlocel, these cells increase and restore the + number of HSPCs, which may prevent or decrease the risk of infection and other + complications of chemotherapy-induced neutropenia (CIN) or cord blood transplantation. + LHD221, an AHR antagonist facilitates the expansion of CD34-positive hematopoietic + progenitors and impedes HSPC differentiation during cytokine-driven expansion + in culture. + termDef: + term: >- + Spanlecortemlocel + source: NCIt + cde_id: C111571 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111571" + term_id: C111571 + term_version: 20.10d + +specc1: + common: + description: >- + This gene may be involved in nuclear structure. + termDef: + term: >- + SPECC1 Gene + source: NCIt + cde_id: C97531 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97531" + term_id: C97531 + term_version: 20.10d + +spen: + common: + description: >- + This gene plays a role in hormone-mediated transcriptional regulation. + termDef: + term: >- + SPEN Gene + source: NCIt + cde_id: C115310 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C115310" + term_id: C115310 + term_version: 20.10d + +spermatic_cord: + common: + description: >- + A tube-like structure composed of the vas deferens and surrounding tissue layers, + that runs from the abdomen to each of the testicles. + termDef: + term: >- + Spermatic Cord + source: NCIt + cde_id: C12329 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12329" + term_id: C12329 + term_version: 20.05a + +spermatocytic_seminoma: + common: + description: >- + A testicular germ cell tumor derived from postpubertal-type germ cells. It is + characterized by the presence of three cell types: round cells with eosinophilic + cytoplasm, small cells with dark nucleus and a small amount of cytoplasm, and + mono-or multinucleated giant cells. The neoplastic cells are not cohesive. There + is an edematous stroma present; lymphocytic infiltrates are rarely seen. Most + patients are older males. + termDef: + term: >- + Testicular Spermatocytic Tumor + source: NCIt + cde_id: C39921 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39921" + term_id: C39921 + term_version: 20.05a + +spermatocytoma: + common: + description: >- + A testicular germ cell tumor derived from postpubertal-type germ cells. It is + characterized by the presence of three cell types: round cells with eosinophilic + cytoplasm, small cells with dark nucleus and a small amount of cytoplasm, and + mono-or multinucleated giant cells. The neoplastic cells are not cohesive. There + is an edematous stroma present; lymphocytic infiltrates are rarely seen. Most + patients are older males. + termDef: + term: >- + Testicular Spermatocytic Tumor + source: NCIt + cde_id: C39921 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39921" + term_id: C39921 + term_version: 20.05a + +sphenoid_sinus: + common: + description: >- + Either of the paired paranasal sinuses, located in the anterior part of the + body of the sphenoid bone and communicating with the superior meatus of the + nasal cavity on the same side. + termDef: + term: >- + Sphenoid Sinus + source: NCIt + cde_id: C12278 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12278" + term_id: C12278 + term_version: 20.05a + +spinal_cord: + common: + description: >- + The elongated, approximately cylindrical part of the central nervous system + of vertebrates that lies in the vertebral canal and from which the spinal nerves + emerge. + termDef: + term: >- + Spinal Cord + source: NCIt + cde_id: C12464 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12464" + term_id: C12464 + term_version: 20.05a + +spinal_meninges: + common: + description: >- + Connective tissue membranes that surround and support the spinal cord and cauda + equina. They are continuous with cranial meninges, which surround and support + the brain. + termDef: + term: >- + Spinal Meninges + source: NCIt + cde_id: C12350 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12350" + term_id: C12350 + term_version: 20.05a + +spinal_muscular_atrophy: + common: + description: >- + An inherited disorder characterized by degeneration of the spinal cord and the + cerebellum. Symptoms may appear at any age and include progressive loss of coordination + of gait, hands, speech, and eye movements. + termDef: + term: >- + Spinal Muscular Atrophy + source: NCIt + cde_id: C85075 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C85075" + term_id: C85075 + term_version: 19.12e + +spindle_cell_angioendothelioma: + common: + description: >- + A hemangioma characterized by the presence of spindle endothelial cells. + termDef: + term: >- + Spindle Cell Hemangioma + source: NCIt + cde_id: C4754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4754" + term_id: C4754 + term_version: 20.05a + +spindle_cell_carcinoma_nos: + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of spindle cells + and anaplastic morphologic features. Giant cells and a sarcomatous component + may also be present. + termDef: + term: >- + Sarcomatoid Carcinoma + source: NCIt + cde_id: C27004 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27004" + term_id: C27004 + term_version: 20.05a + +spindle_cell_hemangioendothelioma: + common: + description: >- + A hemangioma characterized by the presence of spindle endothelial cells. + termDef: + term: >- + Spindle Cell Hemangioma + source: NCIt + cde_id: C4754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4754" + term_id: C4754 + term_version: 20.05a + +spindle_cell_lipoma: + common: + description: >- + A benign circumscribed tumor composed of spindled cells, adipocytes, and collagen + bundles. There is no evidence of nuclear hyperchromasia or mitotic activity. + termDef: + term: >- + Spindle Cell Lipoma + source: NCIt + cde_id: C4254 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4254" + term_id: C4254 + term_version: 20.05a + +spindle_cell_melanoma_nos: + common: + description: >- + A melanoma characterized by the presence of malignant spindle-shaped melanocytes. + termDef: + term: >- + Spindle Cell Melanoma + source: NCIt + cde_id: C4237 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4237" + term_id: C4237 + term_version: 20.05a + +spindle_cell_melanoma_type_a: + common: + description: >- + A melanoma characterized by the presence of malignant spindle-shaped melanocytes + with slender nuclei and no visible nucleoli. Representative example is the type + A spindle cell uveal melanoma. + termDef: + term: >- + Type A Spindle Cell Melanoma + source: NCIt + cde_id: C4238 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4238" + term_id: C4238 + term_version: 20.05a + +spindle_cell_melanoma_type_b: + common: + description: >- + A melanoma characterized by the presence of malignant spindle-shaped melanocytes + with larger nuclei and distinct nucleoli. Representative example is the type + B spindle cell uveal melanoma. + termDef: + term: >- + Type B Spindle Cell Melanoma + source: NCIt + cde_id: C4239 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4239" + term_id: C4239 + term_version: 20.05a + +spindle_cell_nevus_nos: + common: + description: >- + A benign, acquired or congenital, usually single skin lesion. It can occur on + any area of the body, but most commonly occurs on the face of children and the + thighs of young females. It is characterized by a proliferation of large spindle, + oval, or large epithelioid melanocytes in the dermal-epidermal junction. The + melanocytic proliferation subsequently extends into the dermis. + termDef: + term: >- + Spitz Nevus + source: NCIt + cde_id: C27007 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27007" + term_id: C27007 + term_version: 20.05a + +spindle_cell_oncocytoma: + common: + description: >- + A very rare, WHO grade I neoplasm of the posterior pituitary. It is characterized + by the presence of spindle cells with eosinophilic, granular cytoplasm forming + fascicles. Electron microscopic studies demonstrate the accumulation of intracytoplasmic + mitochondria and lack of secretory granules. Immunohistochemical studies are + negative for pituitary hormones. Patients may present with pituitary hypofunction, + visual disturbances, headache, nausea and vomiting. The clinical course is + usually benign. + termDef: + term: >- + Spindle Cell Oncocytoma + source: NCIt + cde_id: C94537 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94537" + term_id: C94537 + term_version: 20.05a + +spindle_cell_rhabdomyosarcoma: + common: + description: >- + An uncommon variant of rhabdomyosarcoma characterized by the presence of whorls + of spindle cells forming a storiform pattern. In children it usually arises + in the paratesticular region. In adults it usually arises from the deep soft + tissues in the head and neck. + termDef: + term: >- + Spindle Cell Rhabdomyosarcoma + source: NCIt + cde_id: C6519 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6519" + term_id: C6519 + term_version: 20.05a + +spindle_cell_sarcoma: + common: + description: >- + A malignant mesenchymal neoplasm composed of spindle-shaped cells. This is + a morphologic term which can be applied to a wide range of sarcomas. + termDef: + term: >- + Spindle Cell Sarcoma + source: NCIt + cde_id: C27005 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27005" + term_id: C27005 + term_version: 20.05a + +spindle_epithelial_tumor_with_thymuslike_differentiation: + common: + description: >- + A rare, slow growing, primary malignant tumor of the thyroid gland characterized + by a lobulated architectural pattern and the presence of a biphasic cellular + population composed of spindle epithelial cells and glandular cells. A small + number of cases are composed exclusively of spindle epithelial cells or glandular + cells. + termDef: + term: >- + Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation + source: NCIt + cde_id: C46105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46105" + term_id: C46105 + term_version: 20.05a + +spindle_epithelial_tumor_with_thymuslike_element: + common: + description: >- + A rare, slow growing, primary malignant tumor of the thyroid gland characterized + by a lobulated architectural pattern and the presence of a biphasic cellular + population composed of spindle epithelial cells and glandular cells. A small + number of cases are composed exclusively of spindle epithelial cells or glandular + cells. + termDef: + term: >- + Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation + source: NCIt + cde_id: C46105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C46105" + term_id: C46105 + term_version: 20.05a + +spindled_mesothelioma: + common: + description: >- + A malignant neoplasm arising from mesothelial cells. It is characterized by + the presence of spindle cells. Anaplastic morphologic features and multinucleated + malignant cells may also be seen. + termDef: + term: >- + Sarcomatoid Mesothelioma + source: NCIt + cde_id: C45655 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45655" + term_id: C45655 + term_version: 20.05a + +spiradenoma_nos: + common: + description: >- + A benign epithelial neoplasm with eccrine or apocrine differentiation, arising + from the sweat glands. It usually presents as a solitary, well circumscribed, + firm nodule in the face and upper trunk. It is characterized by the presence + of basaloid cells forming nodules in the dermis. Cases of carcinoma arising + from long standing spiradenomas have been reported. + termDef: + term: >- + Spiradenoma + source: NCIt + cde_id: C4170 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4170" + term_id: C4170 + term_version: 20.05a + +spitz_nevus: + common: + description: >- + A benign, acquired or congenital, usually single skin lesion. It can occur on + any area of the body, but most commonly occurs on the face of children and the + thighs of young females. It is characterized by a proliferation of large spindle, + oval, or large epithelioid melanocytes in the dermal-epidermal junction. The + melanocytic proliferation subsequently extends into the dermis. + termDef: + term: >- + Spitz Nevus + source: NCIt + cde_id: C27007 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27007" + term_id: C27007 + term_version: 20.05a + +spleen: + common: + description: >- + An organ that is part of the hematopoietic and immune systems. It is composed + of the white pulp and the red pulp and is surrounded by a capsule. It is located + in the left hypochondriac region. Its functions include lymphocyte production, + blood cell storage, and blood cell destruction. + termDef: + term: >- + Spleen + source: NCIt + cde_id: C12432 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12432" + term_id: C12432 + term_version: 20.05a + +spleen_cancer: + common: + description: >- + A malignant neoplasm affecting the spleen. Representative examples include leukemias, + lymphomas, and sarcomas. + termDef: + term: >- + Malignant Splenic Neoplasm + source: NCIt + cde_id: C3539 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3539" + term_id: C3539 + term_version: 19.12e + +splenic: + common: + description: >- + Any lymph node located along the splenic artery that receives afferent drainage + from the pancreas, spleen, and stomach, and which generally has their efferents + join the celiac group of preaortic lymph nodes. + termDef: + term: >- + Splenic Lymph Node + source: NCIt + cde_id: C142320 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142320" + term_id: C142320 + term_version: 20.10d + +splenic_bcell_lymphomaleukemia_unclassifiable: + common: + description: >- + A small B-cell clonal lymphoproliferative disorder of the spleen that does not + fall into any of the other categories of mature B-cell neoplasms. + termDef: + term: >- + Splenic B-Cell Lymphoma/Leukemia, Unclassifiable + source: NCIt + cde_id: C80308 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80308" + term_id: C80308 + term_version: 20.05a + +splenic_diffuse_red_pulp_small_bcell_lymphoma: + common: + description: >- + An uncommon, indolent B-cell non-Hodgkin lymphoma composed of small B-lymphocytes + involving the red pulp of the spleen, bone marrow, and peripheral blood. Patients + often have massive splenomegaly. The peripheral blood examination reveals villous + lymphocytes. + termDef: + term: >- + Splenic Diffuse Red Pulp Small B-Cell Lymphoma + source: NCIt + cde_id: C80309 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80309" + term_id: C80309 + term_version: 20.05a + +splenic_flexure_of_colon: + common: + description: >- + The bend at the junction of the transverse and descending colon. + termDef: + term: >- + Splenic Flexure + source: NCIt + cde_id: C12267 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12267" + term_id: C12267 + term_version: 20.05a + +splenic_marginal_zone_bcell_lymphoma: + common: + description: >- + A B-cell non-Hodgkin lymphoma composed of small lymphocytes which surround and + replace the splenic white pulp germinal centers. It involves the spleen and + splenic hilar lymph nodes, bone marrow, and often the peripheral blood. When + lymphoma cells are present in the peripheral blood, they are usually, but not + always, characterized by the presence of short polar villi. (WHO) + termDef: + term: >- + Splenic Marginal Zone Lymphoma + source: NCIt + cde_id: C4663 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4663" + term_id: C4663 + term_version: 20.05a + +splenic_marginal_zone_lymphoma_nos: + common: + description: >- + A B-cell non-Hodgkin lymphoma composed of small lymphocytes which surround and + replace the splenic white pulp germinal centers. It involves the spleen and + splenic hilar lymph nodes, bone marrow, and often the peripheral blood. When + lymphoma cells are present in the peripheral blood, they are usually, but not + always, characterized by the presence of short polar villi. (WHO) + termDef: + term: >- + Splenic Marginal Zone Lymphoma + source: NCIt + cde_id: C4663 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4663" + term_id: C4663 + term_version: 20.05a + +splice: + common: + description: >- + Any mutation that occurs within the discrete sequences comprising the 5' or + 3' splice sites of a gene that has a spliced message. Splice-site mutation may + result in a deletion or insertion of extraneous amino acids in the gene product + or a change in the reading frame of the spliced message. + termDef: + term: >- + Splice-Site Mutation + source: NCIt + cde_id: C19798 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19798" + term_id: C19798 + term_version: 20.10d + +splice_acceptor_variant: + common: + description: >- + A heritable single nucleotide polymorphism located at the acceptor splice site + in certain allelic variants of eukaryotic genes. These sites are located in + genes at intron to exon junctions at the 3' end of the intron. + termDef: + term: >- + Acceptor Splice Site SNP + source: NCIt + cde_id: C45389 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45389" + term_id: C45389 + term_version: 20.10d + +splice_donor_variant: + common: + description: >- + An inherited single base change at a donor splice site in a genomic DNA sequence + that results in an allelic variant of the wild-type gene. Donor splice sites + are located at exon to intron junctions at the 5' end of the intron. + termDef: + term: >- + Donor Splice Site SNP + source: NCIt + cde_id: C45390 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45390" + term_id: C45390 + term_version: 20.10d + +splice_region_variant: + common: + description: >- + Any mutation that occurs within the discrete sequences comprising the 5' or + 3' splice sites of a gene that has a spliced message. Splice-site mutation may + result in a deletion or insertion of extraneous amino acids in the gene product + or a change in the reading frame of the spliced message. + termDef: + term: >- + Splice-Site Mutation + source: NCIt + cde_id: C19798 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19798" + term_id: C19798 + term_version: 20.10d + +spongioblastoma_multiforme: + common: + description: >- + The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly + differentiated neoplastic astrocytes and it is characterized by the presence + of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, + microvascular proliferation and necrosis. It typically affects adults and is + preferentially located in the cerebral hemispheres. It may develop from diffuse + astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, + IDH-mutant), but more frequently, it manifests after a short clinical history + de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, + IDH- wildtype). (Adapted from WHO) + termDef: + term: >- + Glioblastoma + source: NCIt + cde_id: C3058 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3058" + term_id: C3058 + term_version: 20.05a + +spongioblastoma_polare: + common: + description: >- + A lesion characterized by the presence of neoplastic neuroepithelial cells with + palisading nuclei. This lesion implies a morphologic growth pattern and it is + not considered a clinicopathological entity. + termDef: + term: >- + Polar Spongioblastoma + source: NCIt + cde_id: C66801 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66801" + term_id: C66801 + term_version: 20.05a + +spongioneuroblastoma: + common: + description: >- + A neuroectodermal tumor composed of neoplastic neural elements. + termDef: + term: >- + Spongioneuroblastoma + source: NCIt + cde_id: C66811 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66811" + term_id: C66811 + term_version: 20.05a + +spop: + common: + description: >- + This gene may be involved in both transcriptional repression and protein ubiquitination. + termDef: + term: >- + SPOP Gene + source: NCIt + cde_id: C102534 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102534" + term_id: C102534 + term_version: 20.10d + +sporadic_adult: + common: + description: >- + A clinical variant of Burkitt lymphoma that occurs throughout the world. It + affects both children and adults and is more frequently seen in males. + termDef: + term: >- + Sporadic Burkitt Lymphoma + source: NCIt + cde_id: C27914 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27914" + term_id: C27914 + term_version: 20.05a + +sporadic_pediatric: + common: + description: >- + A clinical variant of Burkitt lymphoma that occurs throughout the world. It + affects both children and adults and is more frequently seen in males. + termDef: + term: >- + Sporadic Burkitt Lymphoma + source: NCIt + cde_id: C27914 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27914" + term_id: C27914 + term_version: 20.05a + +spouse: + common: + description: >- + A person's partner in marriage. + termDef: + term: >- + Spouse + source: NCIt + cde_id: C62649 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62649" + term_id: C62649 + term_version: 19.12e + +squamotransitional_cell_carcinoma: + common: + description: >- + A human papillomavirus-related cervical squamous cell carcinoma characterized + by the presence of papillary structures with fibrovascular cores. It is covered + with multiple layers of atypical cells that resemble cervical intraepithelial + neoplasia 3. + termDef: + term: >- + Cervical Squamotransitional Carcinoma + source: NCIt + cde_id: C40194 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40194" + term_id: C40194 + term_version: 20.05a + +squamous_carcinoma: + common: + description: >- + A carcinoma arising from squamous epithelial cells. Morphologically, it is + characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous + cell carcinomas are graded by the degree of cellular differentiation as well, + moderately, or poorly differentiated. Well differentiated carcinomas are usually + associated with keratin production and the presence of intercellular bridges + between adjacent cells. Representative examples are lung squamous cell carcinoma, + skin squamous cell carcinoma, and cervical squamous cell carcinoma. + termDef: + term: >- + Squamous Cell Carcinoma + source: NCIt + cde_id: C2929 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2929" + term_id: C2929 + term_version: 20.05a + +squamous_cell_carcinoma_acantholytic: + common: + description: >- + A squamous cell carcinoma characterized by the formation of gland-like structures. + termDef: + term: >- + Pseudoglandular Squamous Cell Carcinoma + source: NCIt + cde_id: C4106 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4106" + term_id: C4106 + term_version: 20.05a + +squamous_cell_carcinoma_adenoid: + common: + description: >- + A squamous cell carcinoma characterized by the formation of gland-like structures. + termDef: + term: >- + Pseudoglandular Squamous Cell Carcinoma + source: NCIt + cde_id: C4106 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4106" + term_id: C4106 + term_version: 20.05a + +squamous_cell_carcinoma_antigen_scca: + common: + description: >- + The determination of the squamous cell carcinoma antigen present in a sample. + termDef: + term: >- + Squamous Cell Carcinoma Antigen Measurement + source: NCIt + cde_id: C120660 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C120660" + term_id: C120660 + term_version: 20.10d + +squamous_cell_carcinoma_clear_cell_type: + common: + description: >- + A squamous cell carcinoma characterized by the presence of malignant cells with + clear cytoplasm. + termDef: + term: >- + Squamous Cell Carcinoma, Clear Cell Type + source: NCIt + cde_id: C65180 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65180" + term_id: C65180 + term_version: 20.05a + +squamous_cell_carcinoma_hpvpositive: + common: + description: >- + Human Papillomavirus-Related Squamous Cell Carcinoma + termDef: + term: >- + Human Papillomavirus-Related Squamous Cell Carcinoma + source: NCIt + cde_id: C27683 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27683" + term_id: C27683 + term_version: 20.05a + +squamous_cell_carcinoma_in_situ_nos: + common: + description: >- + A malignant epithelial neoplasm confined to the squamous epithelium, without + invasion of the underlying tissues. + termDef: + term: >- + Stage 0 Squamous Cell Carcinoma + source: NCIt + cde_id: C27093 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27093" + term_id: C27093 + term_version: 20.05a + +squamous_cell_carcinoma_in_situ_with_questionable_stromal_invasion: + common: + description: >- + A malignant epithelial neoplasm involving all the layers of the squamous epithelium, + but it is not certain if it is confined to the squamous epithelium or it has + invaded the basement membrane and the underlying stroma. + termDef: + term: >- + Squamous Cell Carcinoma In Situ with Questionable Stromal Invasion + source: NCIt + cde_id: C65176 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65176" + term_id: C65176 + term_version: 20.05a + +squamous_cell_carcinoma_keratinizing_nos: + common: + description: >- + Squamous cell carcinomas with morphologically prominent production of keratin. + termDef: + term: >- + Keratinizing Squamous Cell Carcinoma + source: NCIt + cde_id: C4105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4105" + term_id: C4105 + term_version: 20.05a + +squamous_cell_carcinoma_large_cell_keratinizing: + common: + description: >- + Squamous cell carcinomas with morphologically prominent production of keratin. + termDef: + term: >- + Keratinizing Squamous Cell Carcinoma + source: NCIt + cde_id: C4105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4105" + term_id: C4105 + term_version: 20.05a + +squamous_cell_carcinoma_large_cell_nonkeratinizing_nos: + common: + description: >- + A squamous cell carcinoma composed of large atypical cells, without morphologic + evidence of keratin production. + termDef: + term: >- + Non-Keratinizing Large Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C65173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65173" + term_id: C65173 + term_version: 20.05a + +squamous_cell_carcinoma_metastatic_nos: + common: + description: >- + A carcinoma that arises from squamous cells and has spread from its original + site of growth to another anatomic site. + termDef: + term: >- + Metastatic Squamous Cell Carcinoma + source: NCIt + cde_id: C4104 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4104" + term_id: C4104 + term_version: 20.05a + +squamous_cell_carcinoma_microinvasive: + common: + description: >- + A squamous cell carcinoma with minimal stromal invasion. + termDef: + term: >- + Microinvasive Squamous Cell Carcinoma + source: NCIt + cde_id: C65178 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65178" + term_id: C65178 + term_version: 20.05a + +squamous_cell_carcinoma_nonkeratinizing_nos: + common: + description: >- + A squamous cell carcinoma composed of large atypical cells, without morphologic + evidence of keratin production. + termDef: + term: >- + Non-Keratinizing Large Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C65173 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65173" + term_id: C65173 + term_version: 20.05a + +squamous_cell_carcinoma_nos: + common: + description: >- + A carcinoma arising from squamous epithelial cells. Morphologically, it is + characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous + cell carcinomas are graded by the degree of cellular differentiation as well, + moderately, or poorly differentiated. Well differentiated carcinomas are usually + associated with keratin production and the presence of intercellular bridges + between adjacent cells. Representative examples are lung squamous cell carcinoma, + skin squamous cell carcinoma, and cervical squamous cell carcinoma. + termDef: + term: >- + Squamous Cell Carcinoma + source: NCIt + cde_id: C2929 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2929" + term_id: C2929 + term_version: 20.05a + +squamous_cell_carcinoma_pseudoglandular: + common: + description: >- + A squamous cell carcinoma characterized by the formation of gland-like structures. + termDef: + term: >- + Pseudoglandular Squamous Cell Carcinoma + source: NCIt + cde_id: C4106 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4106" + term_id: C4106 + term_version: 20.05a + +squamous_cell_carcinoma_sarcomatoid: + common: + description: >- + A poorly differentiated squamous cell carcinoma characterized by the presence + of malignant cells with spindle cell features. + termDef: + term: >- + Spindle Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C27084 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27084" + term_id: C27084 + term_version: 20.05a + +squamous_cell_carcinoma_small_cell_nonkeratinizing: + common: + description: >- + A squamous cell carcinoma composed of small atypical cells, without morphologic + evidence of keratin production. + termDef: + term: >- + Non-Keratinizing Small Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C65175 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65175" + term_id: C65175 + term_version: 20.05a + +squamous_cell_carcinoma_spindle_cell: + common: + description: >- + A poorly differentiated squamous cell carcinoma characterized by the presence + of malignant cells with spindle cell features. + termDef: + term: >- + Spindle Cell Squamous Cell Carcinoma + source: NCIt + cde_id: C27084 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27084" + term_id: C27084 + term_version: 20.05a + +squamous_cell_carcinoma_with_horn_formation: + common: + description: >- + A keratinizing squamous cell carcinoma characterized by the presence of horn + pearls. Representative examples include squamous cell carcinomas of the face + presenting as a cutaneous horn. + termDef: + term: >- + Squamous Cell Carcinoma with Horn Formation + source: NCIt + cde_id: C65179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65179" + term_id: C65179 + term_version: 20.05a + +squamous_cell_epithelioma: + common: + description: >- + A carcinoma arising from squamous epithelial cells. Morphologically, it is + characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous + cell carcinomas are graded by the degree of cellular differentiation as well, + moderately, or poorly differentiated. Well differentiated carcinomas are usually + associated with keratin production and the presence of intercellular bridges + between adjacent cells. Representative examples are lung squamous cell carcinoma, + skin squamous cell carcinoma, and cervical squamous cell carcinoma. + termDef: + term: >- + Squamous Cell Carcinoma + source: NCIt + cde_id: C2929 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2929" + term_id: C2929 + term_version: 20.05a + +squamous_cell_papilloma_inverted: + common: + description: >- + A benign epithelial neoplasm characterized by an endophytic growth, papillary + pattern, and proliferation of neoplastic squamous cells without morphologic + evidence of malignancy. + termDef: + term: >- + Inverted Squamous Cell Papilloma + source: NCIt + cde_id: C65165 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65165" + term_id: C65165 + term_version: 20.05a + +squamous_cell_papilloma_nos: + common: + description: >- + A benign epithelial neoplasm characterized by a papillary growth pattern and + a proliferation of neoplastic squamous cells without morphologic evidence of + malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, + esophagus, vagina, and vulva. + termDef: + term: >- + Squamous Cell Papilloma + source: NCIt + cde_id: C3712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3712" + term_id: C3712 + term_version: 20.05a + +squamous_intraepithelial_neoplasia_grade_i: + common: + description: >- + A precancerous neoplastic process characterized by the presence of mild dysplastic + cytological changes which are usually present in the lower part of the squamous + epithelium. Representative examples include the low grade esophageal squamous + intraepithelial neoplasia, low grade cervical squamous intraepithelial neoplasia, + low grade vaginal intraepithelial neoplasia, and low grade vulvar intraepithelial + neoplasia. + termDef: + term: >- + Low Grade Squamous Intraepithelial Neoplasia + source: NCIt + cde_id: C8335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8335" + term_id: C8335 + term_version: 20.05a + +squamous_intraepithelial_neoplasia_grade_ii: + common: + description: >- + Grade II Squamous Intraepithelial Neoplasia + termDef: + term: >- + Grade II Squamous Intraepithelial Neoplasia + source: NCIt + cde_id: C7351 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7351" + term_id: C7351 + term_version: 20.05a + +squamous_intraepithelial_neoplasia_grade_iii: + common: + description: >- + A malignant epithelial neoplasm confined to the squamous epithelium, without + invasion of the underlying tissues. + termDef: + term: >- + Stage 0 Squamous Cell Carcinoma + source: NCIt + cde_id: C27093 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27093" + term_id: C27093 + term_version: 20.05a + +squamous_intraepithelial_neoplasia_high_grade: + common: + description: >- + A precancerous neoplastic process characterized by the presence of moderate + or severe dysplastic cytological changes which extend to the upper part of the + squamous epithelium. Maturation at the surface of the squamous epithelium may + or may not be present. Representative examples include the high grade esophageal + squamous intraepithelial neoplasia, high grade cervical squamous intraepithelial + neoplasia, high grade vaginal intraepithelial neoplasia, and high grade vulvar + intraepithelial neoplasia. + termDef: + term: >- + High Grade Squamous Intraepithelial Neoplasia + source: NCIt + cde_id: C8336 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8336" + term_id: C8336 + term_version: 20.05a + +squamous_intraepithelial_neoplasia_low_grade: + common: + description: >- + A precancerous neoplastic process characterized by the presence of mild dysplastic + cytological changes which are usually present in the lower part of the squamous + epithelium. Representative examples include the low grade esophageal squamous + intraepithelial neoplasia, low grade cervical squamous intraepithelial neoplasia, + low grade vaginal intraepithelial neoplasia, and low grade vulvar intraepithelial + neoplasia. + termDef: + term: >- + Low Grade Squamous Intraepithelial Neoplasia + source: NCIt + cde_id: C8335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8335" + term_id: C8335 + term_version: 20.05a + +squamous_odontogenic_tumor: + common: + description: >- + A rare, locally invasive neoplasm arising from tooth-forming tissues. It usually + grows intraosseously in the mandible. The maxilla is less frequently involved. + It is characterized by the presence of well differentiated squamous cells which + form islands. Recurrences may rarely occur and probably are related to incomplete + excision of the tumor. + termDef: + term: >- + Squamous Odontogenic Tumor + source: NCIt + cde_id: C7112 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7112" + term_id: C7112 + term_version: 20.05a + +squamous_papilloma: + common: + description: >- + A benign epithelial neoplasm characterized by a papillary growth pattern and + a proliferation of neoplastic squamous cells without morphologic evidence of + malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, + esophagus, vagina, and vulva. + termDef: + term: >- + Squamous Cell Papilloma + source: NCIt + cde_id: C3712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3712" + term_id: C3712 + term_version: 20.05a + +squamous_papillomatosis: + common: + description: >- + A benign squamous neoplasm characterized by a papillary growth pattern, diffusely + involving a specific anatomic site. + termDef: + term: >- + Squamous Papillomatosis + source: NCIt + cde_id: C9009 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9009" + term_id: C9009 + term_version: 20.05a + +src: + common: + description: >- + This gene is involved in apoptosis, hormonogenesis, focal adhesion and the formation + of intercellular junctions. + termDef: + term: >- + SRC Gene + source: NCIt + cde_id: C19917 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C19917" + term_id: C19917 + term_version: 20.10d + +srgap3: + common: + description: >- + This gene plays a role in GTPase-mediated signaling. + termDef: + term: >- + SRGAP3 Gene + source: NCIt + cde_id: C97797 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97797" + term_id: C97797 + term_version: 20.10d + +sri_lanka: + common: + description: >- + A country in southern Asia, occupying an island in the Indian Ocean, southeast + of India. + termDef: + term: >- + Sri Lanka + source: NCIt + cde_id: C17163 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17163" + term_id: C17163 + term_version: 19.12e + +srpk1abcg2_inhibitor_sco101: + common: + description: >- + An orally bioavailable inhibitor of the serine/arginine-rich splicing factor + protein kinase 1 (SRPK1) and the ATP-binding cassette sub-family G member 2 + (ABCG2), with potential chemosensitizing and antineoplastic activities. Upon + oral administration, SRPK1/ABCG2 inhibitor SCO-101 targets, binds to and inhibits + the activity of SRPK1 and ABCG2. Inhibition of the cellular efflux pump ABCG2 + by SCO-101 prevents the efflux of co-administered chemotherapeutic agents from + cancer cells. This may abrogate cancer cell drug resistance and may re-sensitize + cancer cells to the chemotherapeutic agents. Inhibition of SRPK1 kinase by SCO-101 + inhibits the SRPK1-mediated phosphorylation of splicing factors rich in serine/arginine + domains, thereby inhibiting the activation of proteins that are involved in + the regulation of alternative splicing. This may inhibit cancer cell proliferation. + SRPK1 is upregulated in various cancer cell types. Its upregulation is correlated + with higher tumor staging, grading, and shorter survival. + termDef: + term: >- + SRPK1/ABCG2 Inhibitor SCO-101 + source: NCIt + cde_id: C175512 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175512" + term_id: C175512 + term_version: 20.10d + +srsf2: + common: + description: >- + This gene plays a role in RNA splicing. + termDef: + term: >- + SRSF2 Gene + source: NCIt + cde_id: C101110 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101110" + term_id: C101110 + term_version: 20.10d + +srsf3: + common: + description: >- + This gene plays a role in RNA splicing and export. + termDef: + term: >- + SRSF3 Gene + source: NCIt + cde_id: C97785 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97785" + term_id: C97785 + term_version: 20.10d + +ss18: + common: + description: >- + This gene is involved in transcriptional activation. + termDef: + term: >- + SS18 Gene + source: NCIt + cde_id: C97800 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97800" + term_id: C97800 + term_version: 20.10d + +ss18l1: + common: + description: >- + This gene plays a role in the positive regulation of transcription. + termDef: + term: >- + SS18L1 Gene + source: NCIt + cde_id: C97803 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97803" + term_id: C97803 + term_version: 20.10d + +ssx1: + common: + description: >- + This gene may be involved in the regulation of transcription. + termDef: + term: >- + SSX1 Gene + source: NCIt + cde_id: C97806 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97806" + term_id: C97806 + term_version: 20.10d + +ssx2: + common: + description: >- + This gene may play a role in transcriptional regulation. + termDef: + term: >- + SSX2 Gene + source: NCIt + cde_id: C97809 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97809" + term_id: C97809 + term_version: 20.10d + +ssx4: + common: + description: >- + This gene may be involved in transcriptional modulation. + termDef: + term: >- + SSX4 Gene + source: NCIt + cde_id: C97814 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97814" + term_id: C97814 + term_version: 20.10d + +stag1: + common: + description: >- + This gene plays a role in sister chromatid binding. + termDef: + term: >- + STAG1 Gene + source: NCIt + cde_id: C131224 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C131224" + term_id: C131224 + term_version: 20.10d + +stag2: + common: + description: >- + This gene is involved in cell division. + termDef: + term: >- + STAG2 Gene + source: NCIt + cde_id: C101346 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101346" + term_id: C101346 + term_version: 20.10d + +stage_0: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers and refers to carcinoma + in situ. For cervical cancer, it used to refer to cancer that is confined + to the cervical epithelium without stromal invasion; for endometrial cancer, + it used to refer to cancer that is confined to the endometrium without myometrial + invasion. FIGO no longer includes stage 0 cervical or endometrial cancer. + termDef: + term: >- + FIGO Stage 0 + source: NCIt + cde_id: C96243 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96243" + term_id: C96243 + term_version: 20.05a + ajcc_clinical_stage: + description: >- + Cancer confined to the epithelium without invasion of the basement membrane. + termDef: + term: >- + Stage 0 + source: NCIt + cde_id: C28051 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28051" + term_id: C28051 + term_version: 20.05a + +stage_0a: + common: + description: >- + Cancer confined to the epithelium with formation of papillary structures without + invasion of the basement membrane or noninvasive localized squamous cell carcinoma. + termDef: + term: >- + Stage 0a + source: NCIt + cde_id: C27964 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27964" + term_id: C27964 + term_version: 20.05a + +stage_0is: + common: + description: >- + Cancer confined to the epithelium with formation of a flat surface without invasion + of the basement membrane. + termDef: + term: >- + Stage 0is + source: NCIt + cde_id: C27965 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27965" + term_id: C27965 + term_version: 20.05a + +stage_1: + common: + description: >- + The tumor is confined to the original site of growth; no metastasis. + termDef: + term: >- + INSS Stage 1 + source: NCIt + cde_id: C85417 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C85417" + term_id: C85417 + term_version: 20.05a + +stage_2a: + common: + description: >- + The tumor is unilateral and the resection is grossly incomplete; no evidence + of lymph node involvement. + termDef: + term: >- + INSS Stage 2A + source: NCIt + cde_id: C85418 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C85418" + term_id: C85418 + term_version: 20.05a + +stage_2b: + common: + description: >- + The tumor is unilateral and the resection is complete or incomplete; ipsilateral + lymph nodes are involved by tumor. + termDef: + term: >- + INSS Stage 2B + source: NCIt + cde_id: C85419 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C85419" + term_id: C85419 + term_version: 20.05a + +stage_3: + common: + description: >- + The tumor extends across the midline and the regional lymph nodes may or may + not be involved by tumor; or the tumor is unilateral and the contralateral lymph + nodes are involved by tumor; or the tumor is in midline and there is bilateral + lymph node involvement by tumor. + termDef: + term: >- + INSS Stage 3 + source: NCIt + cde_id: C85420 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C85420" + term_id: C85420 + term_version: 20.05a + +stage_4: + common: + description: >- + Tumor spread to distant lymph nodes, bone marrow, bones, and liver. + termDef: + term: >- + INSS Stage 4 + source: NCIt + cde_id: C85421 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C85421" + term_id: C85421 + term_version: 20.05a + +stage_4s: + common: + description: >- + Patients are less than one year old with localized primary tumor and dissemination + limited to the following specific anatomic sites: liver, skin, or bone marrow. + termDef: + term: >- + INSS Stage 4S + source: NCIt + cde_id: C85422 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C85422" + term_id: C85422 + term_version: 20.05a + +stage_i: + diagnosis: + ann_arbor_pathologic_stage: + description: >- + A pathologic stage that refers to lymphoma involving a single lymph node region + or a single extranodal organ (Ie). + termDef: + term: >- + Ann Arbor Pathologic Stage I + source: NCIt + cde_id: C125473 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125473" + term_id: C125473 + term_version: 20.05a + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to invasive cancer that is confined to the cervix; for endometrial + cancer, it refers to cancer confined to the corpus uteri with no or less than + one-half myometrial invasion (IA) or invasion of one-half or more of the myometrium + (IB). + termDef: + term: >- + FIGO Stage I + source: NCIt + cde_id: C96244 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96244" + term_id: C96244 + term_version: 20.05a + cog_renal_stage: + description: >- + Wilms' tumor is limited to the kidney and completely excised; the tumor was + not ruptured before or during removal; the vessels of the renal sinus are + not involved beyond 2 mm; there is no residual tumor present beyond the margins + of excision. + termDef: + term: >- + SIOP/COG/NWTSG Stage I + source: NCIt + cde_id: C140301 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140301" + term_id: C140301 + term_version: 20.05a + ann_arbor_clinical_stage: + description: >- + A clinical stage that refers to lymphoma involving a single lymph node region + or a single extranodal organ (Ie). + termDef: + term: >- + Ann Arbor Clinical Stage I + source: NCIt + cde_id: C125472 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125472" + term_id: C125472 + term_version: 20.05a + masaoka_stage: + description: >- + The tumor is completely encapsulated. + termDef: + term: >- + Masaoka-Koga Stage I + source: NCIt + cde_id: C112007 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112007" + term_id: C112007 + term_version: 20.05a + ensat_pathologic_stage: + description: >- + Stage I includes: T1, N0, M0. Tumor 5 cm or less in greatest dimension. The + tumor has not invaded the surrounding tissues or organs and has not spread + to lymph nodes or distant organs or tissues. + termDef: + term: >- + ENSAT Stage I Adrenal Cortical Carcinoma + source: NCIt + cde_id: C104031 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104031" + term_id: C104031 + term_version: 23.03d + common: + description: >- + Invasive cancer confined to the original anatomic site of growth without lymph + node involvement. + termDef: + term: >- + Stage I + source: NCIt + cde_id: C27966 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27966" + term_id: C27966 + term_version: 20.05a + +stage_ia: + common: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to invasive cancer that is diagnosed microscopically only. The stromal + invasion has a maximum depth of 5.00 mm and a horizontal spread of 7.00 mm or + less; for endometrial cancer, it refers to cancer limited to endometrium or + invades less than one-half of the myometrium. + termDef: + term: >- + FIGO Stage IA + source: NCIt + cde_id: C96245 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96245" + term_id: C96245 + term_version: 20.05a + diagnosis: + enneking_msts_stage: + description: >- + A stage for malignant musculoskeletal tumors characterized by low grade (G1), + intracomparmental site (T1), and no metastasis (M0). + termDef: + term: >- + Enneking Stage IA + source: NCIt + cde_id: C146701 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146701" + term_id: C146701 + term_version: 20.05a + figo_stage: + description: >- + Invasive cancer confined to the original anatomic site of growth without lymph + node involvement. The definition of stage IA depends on the particular type + of cancer that it refers to; for example, for breast cancer, stage IA is defined + as follows: T1, N0, M0. T1: Tumor 20 mm or less in greatest dimension. T1 + includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. N0: No regional + lymph node metastasis. M0: No clinical or radiographic evidence of distant + metastasis. M0 includes M0(i+); for bone cancer, stage IA is defined as follows: + T1, N0, M0, G1, GX. T1: Tumor 8 cm or less in greatest dimension. N0: No regional + lymph node metastasis. M0: No distant metastasis. G1: Well differentiated-low + grade. GX: Grade cannot be assessed. (partially adapted from AJCC 8th ed.) + termDef: + term: >- + Stage IA + source: NCIt + cde_id: C27975 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27975" + term_id: C27975 + term_version: 20.05a + +stage_ia1: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to invasive cancer that is diagnosed microscopically only. The + stromal invasion has a maximum depth of 3.00 mm and a horizontal spread of + 7.00 mm or less; there is no FIGO stage IA1 for endometrial cancer. + termDef: + term: >- + FIGO Stage IA1 + source: NCIt + cde_id: C96246 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96246" + term_id: C96246 + term_version: 20.05a + common: + description: >- + A stage term referring to invasive cervical and lung cancer. For cervical cancer, + it includes: T1a1, N0, M0. T1a1: Tumor with stromal invasion 3.0 mm or less + in depth and 7.0 mm or less in horizontal spread. N0: No regional lymph node + metastasis. M0: No distant metastasis. For lung cancer, it includes: (T1mi, + N0, M0); (T1a, N0, M0). T1mi: Minimally invasive adenocarcinoma: adenocarcinoma + (3 cm or less in greatest dimension) with a predominantly lepidic pattern and + 5 mm or less invasion in greatest dimension. T1a: Tumor measuring 1 cm or less + in greatest dimension. A superficial, spreading tumor of any size whose invasive + component is limited to the bronchial wall and may extend proximal to the main + bronchus also is classified as T1a, but these tumors are uncommon. N0: No regional + lymph node metastasis. M0: No distant metastasis. (adapted from AJCC) + termDef: + term: >- + Stage IA1 + source: NCIt + cde_id: C27983 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27983" + term_id: C27983 + term_version: 20.05a + +stage_ia2: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to invasive cancer that is diagnosed microscopically only. The + stromal invasion is more than 3.00 mm but no more than 5.00 mm with a horizontal + spread of 7.00 mm or less; there is no FIGO stage A2 for endometrial cancer. + termDef: + term: >- + FIGO Stage IA2 + source: NCIt + cde_id: C96247 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96247" + term_id: C96247 + term_version: 20.05a + common: + description: >- + A stage term referring to invasive cervical cancer and invasive lung cancer. + For cervical cancer, it includes: T1a2, N0, M0. T1a2: Tumor with stromal invasion + more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or + less. N0: No regional lymph node metastasis. M0: No distant metastasis. For + lung cancer, it includes: T1b, N0, M0. T1b: Tumor measuring more than 1 cm but + 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: + No distant metastasis. (adapted from AJCC) + termDef: + term: >- + Stage IA2 + source: NCIt + cde_id: C27984 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27984" + term_id: C27984 + term_version: 20.05a + +stage_ib: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to invasive cancer that is clinically visible and is confined to + the cervix or it is diagnosed microscopically and the stromal invasion is + more than 5.00 mm and the horizontal spread is more than 7.00 mm; for endometrial + cancer, it refers to cancer that is confined to the uterine body and invades + one-half or more of the myometrium. + termDef: + term: >- + FIGO Stage IB + source: NCIt + cde_id: C96248 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96248" + term_id: C96248 + term_version: 20.05a + enneking_msts_stage: + description: >- + A stage for malignant musculoskeletal tumors characterized by low grade (G1), + extracomparmental site (T2), and no metastasis (M0). + termDef: + term: >- + Enneking Stage IB + source: NCIt + cde_id: C146702 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146702" + term_id: C146702 + term_version: 20.05a + common: + description: >- + Invasive cancer confined to the original anatomic site of growth without lymph + node involvement. The definition of stage IB depends on the particular type + of cancer that it refers to; for example, for breast cancer, stage IB is defined + as follows: (T0, N1mi, M0); (T1, N1mi, M0). T0: No evidence of primary tumor. + T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor + 1 mm or less in greatest dimension. N1mi: Nodal micrometastases. M0: No clinical + or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone + cancer, stage IB is defined as follows: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, + G1, G2, GX). T2: Tumor more than 8 cm in greatest dimension. T3: Discontinuous + tumors in the primary bone site. N0: No regional lymph node metastasis. M0: + No distant metastasis. G1: Well differentiated-low grade. G2: Moderately differentiated-low + grade. GX: Grade cannot be assessed. (partially adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IB + source: NCIt + cde_id: C27976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27976" + term_id: C27976 + term_version: 20.05a + +stage_ib_cervix: + common: + description: >- + Invasive cancer confined to the original anatomic site of growth without lymph + node involvement. The definition of stage IB depends on the particular type + of cancer that it refers to; for example, for breast cancer, stage IB is defined + as follows: (T0, N1mi, M0); (T1, N1mi, M0). T0: No evidence of primary tumor. + T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor + 1 mm or less in greatest dimension. N1mi: Nodal micrometastases. M0: No clinical + or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone + cancer, stage IB is defined as follows: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, + G1, G2, GX). T2: Tumor more than 8 cm in greatest dimension. T3: Discontinuous + tumors in the primary bone site. N0: No regional lymph node metastasis. M0: + No distant metastasis. G1: Well differentiated-low grade. G2: Moderately differentiated-low + grade. GX: Grade cannot be assessed. (partially adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IB + source: NCIt + cde_id: C27976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27976" + term_id: C27976 + term_version: 20.05a + +stage_ib1: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to clinically visible lesions that measure 4.0 cm or less in diameter; + there is no FIGO stage IB1 for endometrial cancer. + termDef: + term: >- + FIGO Stage IB1 + source: NCIt + cde_id: C96249 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96249" + term_id: C96249 + term_version: 20.05a + common: + description: >- + A stage term referring to invasive cervical cancer that is confined to the cervix + without lymph node involvement. It includes: T1b1, N0, M0. T1b1: Clinically + visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node + metastasis. M0: No distant metastasis. (partially adapted from AJCC) + termDef: + term: >- + Stage IB1 + source: NCIt + cde_id: C28052 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28052" + term_id: C28052 + term_version: 20.05a + +stage_ib2: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to clinically visible lesions that measure more than 4.0 cm in diameter; + there is no FIGO stage IB2 for endometrial cancer. + termDef: + term: >- + FIGO Stage IB2 + source: NCIt + cde_id: C96250 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96250" + term_id: C96250 + term_version: 20.05a + common: + description: >- + A stage term referring to invasive cervical cancer that is confined to the cervix + without lymph node involvement. It includes: T1b2, N0, M0. T1b2: Clinically + visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph + node metastasis. M0: No distant metastasis. (partially adapted from AJCC) + termDef: + term: >- + Stage IB2 + source: NCIt + cde_id: C28053 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28053" + term_id: C28053 + term_version: 20.05a + +stage_ic: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + there is no FIGO stage IC; for endometrial cancer, in the older FIGO classification + stage scheme, it referred to invasion of more than a half of the myometrium. Stage + IC for endometrial cancer has been eliminated in the most recent (2010) FIGO + classification stage scheme. + termDef: + term: >- + FIGO Stage IC + source: NCIt + cde_id: C96251 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96251" + term_id: C96251 + term_version: 20.05a + common: + description: >- + A cancer stage generally indicating the local invasion of tissues by cancer + at the primary site. + termDef: + term: >- + Stage IC + source: NCIt + cde_id: C27981 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27981" + term_id: C27981 + term_version: 20.05a + +stage_ic1: + common: + description: >- + A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and + primary peritoneal cancer. It refers to cancer with surgical spill. + termDef: + term: >- + FIGO Stage IC1 + source: NCIt + cde_id: C128099 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128099" + term_id: C128099 + term_version: 20.05a + +stage_ic2: + common: + description: >- + A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and + primary peritoneal cancer. It refers to cancer with capsule rupture before surgery + or tumor on ovarian surface. + termDef: + term: >- + FIGO Stage IC2 + source: NCIt + cde_id: C128100 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128100" + term_id: C128100 + term_version: 20.05a + +stage_ic3: + common: + description: >- + A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and + primary peritoneal cancer. It refers to cancer with malignant cells in the ascites + or peritoneal washings. + termDef: + term: >- + FIGO Stage IC3 + source: NCIt + cde_id: C128101 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128101" + term_id: C128101 + term_version: 20.05a + +stage_ii: + diagnosis: + ann_arbor_pathologic_stage: + description: >- + A pathologic stage that refers to lymphoma involving two or more node regions + on the same side of the diaphragm or a single extranodal organ plus its regional + lymph nodes with or without other nodes on the same side of the diaphragm + (IIe). + termDef: + term: >- + Ann Arbor Pathologic Stage II + source: NCIt + cde_id: C125475 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125475" + term_id: C125475 + term_version: 20.05a + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer that invades beyond the cervix, but not to the pelvic + wall or lower third of the vagina; for endometrial cancer, it refers to cancer + that invades the stromal connective tissue of the cervix, but it does not + extend beyond the uterus. + termDef: + term: >- + FIGO Stage II + source: NCIt + cde_id: C96252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96252" + term_id: C96252 + term_version: 20.05a + ann_arbor_clinical_stage: + description: >- + A clinical stage that refers to lymphoma involving two or more node regions + on the same side of the diaphragm or a single extranodal organ plus its regional + lymph nodes with or without other nodes on the same side of the diaphragm + (IIe). + termDef: + term: >- + Ann Arbor Clinical Stage II + source: NCIt + cde_id: C125474 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125474" + term_id: C125474 + term_version: 20.05a + cog_renal_stage: + description: >- + Wilms' tumor extends beyond the kidney but is completely excised; no residual + tumor is apparent at or beyond the margins of the excision; tumor thrombus + in vessels outside the kidney is Stage II if the thrombus is removed en bloc + with the tumor. + termDef: + term: >- + SIOP/COG/NWTSG Stage II + source: NCIt + cde_id: C140303 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140303" + term_id: C140303 + term_version: 20.05a + ensat_pathologic_stage: + description: >- + Stage II includes: T2, N0, M0. Tumor greater than 5 cm. The tumor has not + invaded surrounding tissues or organs and has not spread to lymph nodes or + distant organs or tissues. + termDef: + term: >- + ENSAT Stage II Adrenal Cortical Carcinoma + source: NCIt + cde_id: C104032 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104032" + term_id: C104032 + term_version: 23.03d + common: + description: >- + Invasive cancer more extensive than stage I, usually involving local lymph nodes + without spread to distant anatomic sites. + termDef: + term: >- + Stage II + source: NCIt + cde_id: C28054 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28054" + term_id: C28054 + term_version: 20.05a + +stage_ii_cervix: + common: + description: >- + Invasive cancer more extensive than stage I, usually involving local lymph nodes + without spread to distant anatomic sites. + termDef: + term: >- + Stage II + source: NCIt + cde_id: C28054 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28054" + term_id: C28054 + term_version: 20.05a + +stage_iia: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer that invades beyond the cervix, but not to the pelvic + wall or lower third of the vagina and there is no parametrial invasion; for + endometrial cancer, in the older FIGO classification stage scheme, it referred + to endocervical glandular involvement only. Stage IIA for endometrial cancer + has been eliminated in the most recent (2010) FIGO classification stage scheme. + termDef: + term: >- + FIGO Stage IIA + source: NCIt + cde_id: C96253 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96253" + term_id: C96253 + term_version: 20.05a + enneking_msts_stage: + description: >- + A stage for malignant musculoskeletal tumors characterized by high grade (G2), + intracomparmental site (T1), and no metastasis (M0). + termDef: + term: >- + Enneking Stage IIA + source: NCIt + cde_id: C146703 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146703" + term_id: C146703 + term_version: 20.05a + masaoka_stage: + description: >- + The tumor shows microscopic invasion into the capsule. + termDef: + term: >- + Masaoka-Koga Stage IIa + source: NCIt + cde_id: C112008 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112008" + term_id: C112008 + term_version: 20.05a + common: + description: >- + Invasive cancer more extensive than stage I, usually involving local lymph nodes + without spread to distant anatomic sites. The definition of stage IIA depends + on the particular type of cancer that it refers to; for example, for breast + cancer, stage IIA is defined as follows: (T0, N1, M0); (T1, N1, M0); (T2, N0, + M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. + T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor + more than 20 mm but not more than 50 mm in greatest dimension. N1: Metastasis + to movable ipsilateral level I, II axillary lymph node(s). N0: No regional lymph + node metastasis. M0: No clinical or radiographic evidence of distant metastasis. + M0 includes M0(i+); for bone cancer, stage IIA is defined as follows: T1, N0, + M0, G3, G4. T1: Tumor 8 cm or less in greatest dimension. N0: No regional lymph + node metastasis. M0: No distant metastasis. G3: Poorly differentiated. G4: Undifferentiated. + (partially adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IIA + source: NCIt + cde_id: C27967 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27967" + term_id: C27967 + term_version: 20.05a + +stage_iia_cervix: + common: + description: >- + Invasive cancer more extensive than stage I, usually involving local lymph nodes + without spread to distant anatomic sites. The definition of stage IIA depends + on the particular type of cancer that it refers to; for example, for breast + cancer, stage IIA is defined as follows: (T0, N1, M0); (T1, N1, M0); (T2, N0, + M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. + T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor + more than 20 mm but not more than 50 mm in greatest dimension. N1: Metastasis + to movable ipsilateral level I, II axillary lymph node(s). N0: No regional lymph + node metastasis. M0: No clinical or radiographic evidence of distant metastasis. + M0 includes M0(i+); for bone cancer, stage IIA is defined as follows: T1, N0, + M0, G3, G4. T1: Tumor 8 cm or less in greatest dimension. N0: No regional lymph + node metastasis. M0: No distant metastasis. G3: Poorly differentiated. G4: Undifferentiated. + (partially adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IIA + source: NCIt + cde_id: C27967 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27967" + term_id: C27967 + term_version: 20.05a + +stage_iia1: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer limited to the upper two-thirds of the vagina without + parametrial involvement, less than 4 cm in greatest dimension. + termDef: + term: >- + FIGO Stage IIA1 + source: NCIt + cde_id: C162223 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C162223" + term_id: C162223 + term_version: 20.05a + common: + description: >- + A stage term that applies to cervical cancer and indicates that the tumor invades + beyond the uterus but not to the pelvic wall or to the lower third of vagina. + There is no parametrial invasion. The lesion is clinically visible and measures + 4.0 cm or less in greatest dimension. + termDef: + term: >- + Stage IIA1 + source: NCIt + cde_id: C95177 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95177" + term_id: C95177 + term_version: 20.05a + +stage_iia2: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer limited to the upper two-thirds of the vagina without + parametrial involvement, equal or more than 4 cm in greatest dimension. + termDef: + term: >- + FIGO Stage IIA2 + source: NCIt + cde_id: C162224 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C162224" + term_id: C162224 + term_version: 20.05a + common: + description: >- + A stage term that applies to cervical cancer and indicates that the tumor invades + beyond the uterus but not to the pelvic wall or to the lower third of vagina. + There is no parametrial invasion. The lesion is clinically visible and measures + more than 4.0 cm in greatest dimension. + termDef: + term: >- + Stage IIA2 + source: NCIt + cde_id: C95178 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95178" + term_id: C95178 + term_version: 20.05a + +stage_iib: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer that invades beyond the cervix, but not to the pelvic + wall or lower third of the vagina and there is parametrial invasion; for endometrial + cancer, in the older FIGO classification stage scheme, it referred to cervical + stromal invasion. Stage IIB for endometrial cancer has been eliminated in + the most recent (2010) FIGO classification stage scheme. + termDef: + term: >- + FIGO Stage IIB + source: NCIt + cde_id: C96254 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96254" + term_id: C96254 + term_version: 20.05a + enneking_msts_stage: + description: >- + A stage for malignant musculoskeletal tumors characterized by high grade (G2), + intracomparmental site (T2), and no metastasis (M0). + termDef: + term: >- + Enneking Stage IIB + source: NCIt + cde_id: C146704 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146704" + term_id: C146704 + term_version: 20.05a + masaoka_stage: + description: >- + The tumor shows invasion through the capsule and into the surrounding fatty + tissue. + termDef: + term: >- + Masaoka-Koga Stage IIb + source: NCIt + cde_id: C112009 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112009" + term_id: C112009 + term_version: 20.05a + common: + description: >- + Invasive cancer more extensive than stage I, usually involving local lymph nodes + without spread to distant anatomic sites. The definition of stage IIB depends + on the particular type of cancer that it refers to; for example, for breast + cancer, stage IIB is defined as follows: (T2, N1, MO); (T3, NO, MO). T2: Tumor + more than 20 mm but not more than 50 mm in greatest dimension. T3: Tumor more + than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level + I, II axillary lymph node(s). N0: No regional lymph node metastasis. M0: No + clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); + for bone cancer, stage IIB is defined as follows: T2, N0, M0, G3, G4. T2: Tumor + more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. + M0: No distant metastasis. G3: Poorly differentiated. G4: Undifferentiated. + (partially adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IIB + source: NCIt + cde_id: C27968 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27968" + term_id: C27968 + term_version: 20.05a + +stage_iic: + common: + description: >- + A cancer stage generally indicating the invasion of adjacent structures by cancer + without distant metastases. + termDef: + term: >- + Stage IIC + source: NCIt + cde_id: C27969 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27969" + term_id: C27969 + term_version: 20.05a + +stage_iii: + common: + description: >- + Locally advanced cancer that has spread to nearby organs but not to distant + anatomic sites. + termDef: + term: >- + Stage III + source: NCIt + cde_id: C27970 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27970" + term_id: C27970 + term_version: 20.05a + diagnosis: + ann_arbor_pathologic_stage: + description: >- + A pathologic stage that refers to lymphoma involving node regions on both + sides of the diaphragm, or an extralymphatic organ or site plus nodes on both + sides of the diaphragm (IIIe), or lymph nodes on both sides of the diaphragm + plus spleen (IIIs). + termDef: + term: >- + Ann Arbor Pathologic Stage III + source: NCIt + cde_id: C125477 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125477" + term_id: C125477 + term_version: 20.05a + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer that extends to the pelvic wall, and/or involves the lower + third of vagina, and/or causes hydronephrosis or non-functioning kidney; for + endometrial cancer, FIGO stage III is subdivided into stages IIIA and IIIB; + in FIGO stage IIIA, there is involvement of the serosa and/or the adnexa; + for FIGO stage IIIB, there is vaginal or parametrial involvement. + termDef: + term: >- + FIGO Stage III + source: NCIt + cde_id: C96255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96255" + term_id: C96255 + term_version: 20.05a + ann_arbor_clinical_stage: + description: >- + A clinical stage that refers to lymphoma involving node regions on both sides + of the diaphragm, or an extralymphatic organ or site plus nodes on both sides + of the diaphragm (IIIe), or lymph nodes on both sides of the diaphragm plus + spleen (IIIs). + termDef: + term: >- + Ann Arbor Clinical Stage III + source: NCIt + cde_id: C125476 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125476" + term_id: C125476 + term_version: 20.05a + enneking_msts_stage: + description: >- + A stage for malignant musculoskeletal tumors characterized by any grade, any + site, and regional or distant metastasis (M1). + termDef: + term: >- + Enneking Stage III + source: NCIt + cde_id: C146705 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C146705" + term_id: C146705 + term_version: 20.05a + masaoka_stage: + description: >- + The tumor shows invasion into the neighboring tissues and organs of the lower + neck or upper chest. + termDef: + term: >- + Masaoka-Koga Stage III + source: NCIt + cde_id: C112010 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112010" + term_id: C112010 + term_version: 20.05a + cog_renal_stage: + description: >- + Residual Wilms' tumor confined to the abdomen; Lymph nodes in the renal hilum, + the periaortic chains, or beyond are found to contain tumor; diffuse peritoneal + contamination by the tumor; implants are found on the peritoneal surfaces; + tumor extends beyond the surgical margins either microscopically or grossly; + tumor is not completely resectable because of local infiltration into vital + structures. + termDef: + term: >- + SIOP/COG/NWTSG Stage III + source: NCIt + cde_id: C140305 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140305" + term_id: C140305 + term_version: 20.05a + ensat_pathologic_stage: + description: >- + Stage III includes: T3/T4, N0/N1, M0. Tumor of any size that has spread to + the fat outside the adrenal gland or into nearby organs or tissues and/or + has spread to the regional lymph nodes. + termDef: + term: >- + ENSAT Stage III Adrenal Cortical Carcinoma + source: NCIt + cde_id: C104033 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104033" + term_id: C104033 + term_version: 23.03d + +stage_iiia: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer that involves the lower third of vagina and there is no + extension to the pelvic wall; for endometrial cancer, it refers to cancer + with involvement of the serosa and/or the adnexa. + termDef: + term: >- + FIGO Stage IIIA + source: NCIt + cde_id: C96256 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96256" + term_id: C96256 + term_version: 20.05a + common: + description: >- + Locally advanced cancer that has spread to nearby organs but not to distant + anatomic sites. The definition of stage IIIA depends on the particular type + of cancer that it refers to; for example, for breast cancer, stage IIIA is defined + as follows: (T0, N2, M0); (T1, N2, M0); (T2, N2, M0); (T3, N1, M0); (T3, N2, + M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. + T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor + more than 20 mm but not more than 50 mm in greatest dimension. T3: Tumor more + than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level + I, II axillary lymph node(s). N2: Metastases in ipsilateral level I, II axillary + lymph nodes that are clinically fixed or matted; or in clinically detected ipsilateral + internal mammary nodes in the absence of clinically evident axillary lymph node + metastases. M0: No clinical or radiographic evidence of distant metastasis. + M0 includes M0(i+); for cervical cancer, stage IIIA is defined as follows: T3a, + N0, M0. T3a: Tumor involves lower third of vagina, no extension to pelvic wall. + N0: No regional lymph node metastasis. M0: No distant metastasis. (partially + adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IIIA + source: NCIt + cde_id: C27977 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27977" + term_id: C27977 + term_version: 20.05a + +stage_iiia1: + common: + description: >- + A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and + primary peritoneal cancer. It refers to cancer with positive retroperitoneal + lymph nodes only. + termDef: + term: >- + FIGO Stage IIIA1 + source: NCIt + cde_id: C128102 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128102" + term_id: C128102 + term_version: 20.05a + +stage_iiia2: + common: + description: >- + A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and + primary peritoneal cancer. It refers to cancer with microscopic, extrapelvic + (above the brim) peritoneal involvement +/- positive retroperitoneal lymph nodes. + termDef: + term: >- + FIGO Stage IIIA2 + source: NCIt + cde_id: C128105 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128105" + term_id: C128105 + term_version: 20.05a + +stage_iiiai: + common: + description: >- + A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and + primary peritoneal cancer. It refers to cancer with positive retroperitoneal + lymph nodes only. Metastasis equal or less than 10 mm. + termDef: + term: >- + FIGO Stage IIIA1(i) + source: NCIt + cde_id: C128103 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128103" + term_id: C128103 + term_version: 20.05a + +stage_iiiaii: + common: + description: >- + A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and + primary peritoneal cancer. It refers to cancer with positive retroperitoneal + lymph nodes only. Metastasis greater than 10 mm. + termDef: + term: >- + FIGO Stage IIIA1(ii) + source: NCIt + cde_id: C128104 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128104" + term_id: C128104 + term_version: 20.05a + +stage_iiib: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer that extends to the pelvic wall, and/or causes hydronephrosis + or non-functioning kidney; for endometrial cancer, it refers to cancer with + vaginal or parametrial involvement. + termDef: + term: >- + FIGO Stage IIIB + source: NCIt + cde_id: C96257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96257" + term_id: C96257 + term_version: 20.05a + common: + description: >- + Locally advanced cancer that has spread to nearby organs but not to distant + anatomic sites. The definition of stage IIIB depends on the particular type + of cancer that it refers to; for example, for breast cancer, stage IIIB is defined + as follows: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Tumor of any size + with direct extension to the chest wall and/or to the skin (ulceration or skin + nodules). N0: No regional lymph node metastasis. N1: Metastasis to movable ipsilateral + level I, II axillary lymph node(s). N2: Metastases in ipsilateral level I, II + axillary lymph nodes that are clinically fixed or matted; or in clinically detected + ipsilateral internal mammary nodes in the absence of clinically evident axillary + lymph node metastases. M0: No clinical or radiographic evidence of distant metastasis. + M0 includes M0(i+); for cervical cancer, stage IIIB is defined as follows: (T3b, + Any N, M0); (T1-3, N1, M0). T3: Tumor extends to pelvic wall and/or involves + lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. + T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning + kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (partially + adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IIIB + source: NCIt + cde_id: C27978 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27978" + term_id: C27978 + term_version: 20.05a + +stage_iiic: + common: + description: >- + Locally advanced cancer that has spread to nearby organs but not to distant + anatomic sites. The definition of stage IIIC depends on the particular type + of cancer that it refers to; for example, for breast cancer, stage IIIC is defined + as follows: Any T, N3, M0. N3: Metastases in ipsilateral infraclavicular (level + III) axillary lymph nodes(s) with or without level I, II axillary lymph node + involvement; or in clinically detected ipsilateral internal mammary lymph node(s) + with clinically evident level I, II axillary lymph node metastases; or metastases + in ipsilateral supraclavicular lymph node(s) with or without axillary or internal + mammary lymph node involvement. M0: No clinical or radiographic evidence of + distant metastasis. M0 includes M0(i+); for appendix carcinoma, stage IIIC is + defined as follows: Any T, N2, M0. N2: Metastasis in four or more regional lymph + nodes. M0: No distant metastasis. (partially adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IIIC + source: NCIt + cde_id: C27982 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27982" + term_id: C27982 + term_version: 20.05a + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. There is no FIGO stage + IIIC for cervical cancer; for endometrial cancer, FIGO stage IIIC is subdivided + into stages IIIC1 and IIIC2; in FIGO stage IIIC1, there is regional metastasis + to pelvic lymph nodes; for FIGO stage IIIC2, there is regional metastasis + to para-aortic lymph nodes with or without metastasis to pelvic lymph nodes. + termDef: + term: >- + FIGO Stage IIIC + source: NCIt + cde_id: C96258 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96258" + term_id: C96258 + term_version: 20.05a + +stage_iiic1: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. There is no FIGO stage + IIIC1 for cervical cancer; for endometrial cancer, it refers to regional metastasis + to pelvic lymph nodes. + termDef: + term: >- + FIGO Stage IIIC1 + source: NCIt + cde_id: C96259 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96259" + term_id: C96259 + term_version: 20.05a + common: + description: >- + A stage term that applies to uterine corpus cancer and indicates that the tumor + is confined to the corpus uteri, or it invades the stromal connective tissue + of the cervix but does not extend beyond the uterus, or it involves serosa and/or + adnexa, vagina, or parametrial tissue. There is regional lymph node metastasis + to the pelvic lymph nodes. + termDef: + term: >- + Stage IIIC1 + source: NCIt + cde_id: C95179 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95179" + term_id: C95179 + term_version: 20.05a + +stage_iiic2: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. There is no FIGO stage + IIIC2 for cervical cancer; for endometrial cancer, it refers to regional metastasis + to para-aortic lymph nodes with or without metastasis to pelvic lymph nodes. + termDef: + term: >- + FIGO Stage IIIC2 + source: NCIt + cde_id: C96260 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96260" + term_id: C96260 + term_version: 20.05a + common: + description: >- + A stage term that applies to uterine corpus cancer and indicates that the tumor + is confined to the corpus uteri, or it invades stromal connective tissue of + the cervix but does not extend beyond the uterus, or it involves serosa and/or + adnexa, vagina, or parametrial tissue. There is regional lymph node metastasis + to para-aortic lymph nodes, with or without positive pelvic lymph nodes. + termDef: + term: >- + Stage IIIC2 + source: NCIt + cde_id: C95180 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95180" + term_id: C95180 + term_version: 20.05a + +stage_iiid: + common: + description: >- + Locally advanced cancer that has spread to nearby organs but not to distant + anatomic sites. The definition of stage IIID depends on the particular type + of cancer that it refers to; for example, for cutaneous melanoma, stage IIID + is defined as follows: T4b, N3a/b/c, M0. T4b: Tumor measuring more than 4.0 + mm in thickness. Ulceration status: With ulceration. N3a: Four or more clinically + occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence + of in-transit, satellite, and/or microsatellite metastases: No. N3b: Four or + more nodal metastases, at least one of which was clinically detected, or presence + of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite + metastases: No. N3c: Two or more clinically occult nodal metastases. Presence + of in-transit, satellite, and/or microsatellite metastases: Yes. M0: No evidence + of distant metastasis. LDH level is not applicable. (partially adapted from + AJCC 8th ed.) + termDef: + term: >- + Stage IIID + source: NCIt + cde_id: C137676 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137676" + term_id: C137676 + term_version: 20.05a + +stage_is: + common: + description: >- + Testicular cancer found in the testicle, spermatic cord and scrotum, associated + with slightly elevated levels of all tumor markers or moderately/highly elevated + levels of one or more tumor markers. + termDef: + term: >- + Stage Is + source: NCIt + cde_id: C28285 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28285" + term_id: C28285 + term_version: 20.05a + +stage_iv: + diagnosis: + ann_arbor_pathologic_stage: + description: >- + A pathologic stage that refers to diffuse extralymphatic involvement by lymphoma. + termDef: + term: >- + Ann Arbor Pathologic Stage IV + source: NCIt + cde_id: C125479 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125479" + term_id: C125479 + term_version: 20.05a + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer that invades the mucosa of bladder or rectum, and/or extends + beyond the true pelvis (FIGO stage IVA), or to cancer with distant metastases + (FIGO stage IVB); for endometrial cancer, it refers to cancer that invades + the bladder mucosa and/or the bowel mucosa (FIGO stage IVA), or to cancer + with distant metastases (FIGO stage IVB). + termDef: + term: >- + FIGO Stage IV + source: NCIt + cde_id: C96261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96261" + term_id: C96261 + term_version: 20.05a + ann_arbor_clinical_stage: + description: >- + A clinical stage that refers to diffuse extralymphatic involvement by lymphoma. + termDef: + term: >- + Ann Arbor Clinical Stage IV + source: NCIt + cde_id: C125478 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125478" + term_id: C125478 + term_version: 20.05a + cog_renal_stage: + description: >- + Presence of hematogenous metastases or metastases to distant lymph nodes. + termDef: + term: >- + SIOP/COG/NWTSG Stage IV + source: NCIt + cde_id: C140307 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140307" + term_id: C140307 + term_version: 20.05a + ensat_pathologic_stage: + description: >- + Stage IV includes: Any T, Any N, M1. Tumor of any size that involves distant + organs such as liver, bone or brain. The tumor may or may not involve nearby + organs, tissues or lymph nodes. + termDef: + term: >- + ENSAT Stage IV Adrenal Cortical Carcinoma + source: NCIt + cde_id: C104034 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104034" + term_id: C104034 + term_version: 23.03d + common: + description: >- + Cancer that has spread to distant anatomic sites beyond its original site of + growth. + termDef: + term: >- + Stage IV + source: NCIt + cde_id: C27971 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27971" + term_id: C27971 + term_version: 20.05a + +stage_iva: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer that invades the mucosa of bladder or rectum, and/or extends + beyond the true pelvis; for endometrial cancer, it refers to cancer that invades + the bladder mucosa and/or the bowel mucosa. + termDef: + term: >- + FIGO Stage IVA + source: NCIt + cde_id: C96262 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96262" + term_id: C96262 + term_version: 20.05a + masaoka_stage: + description: >- + The tumor shows metastasis throughout the pleural and/or pericardial spaces. + termDef: + term: >- + Masaoka-Koga Stage IVa + source: NCIt + cde_id: C112011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112011" + term_id: C112011 + term_version: 20.05a + common: + description: >- + Cancer that has spread to distant anatomic sites beyond its original site of + growth. The definition of stage IVA depends on the particular type of cancer + that it refers to; for example, for bone cancer, stage IVA is defined as follows: + Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Distant metastasis + to lung; for vaginal cancer, stage IVA is defined as follows: T4, Any N, M0. + T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the + true pelvis (bullous edema is not sufficient evidence to classify a tumor as + T4). M0: No distant metastasis. (partially adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IVA + source: NCIt + cde_id: C27979 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27979" + term_id: C27979 + term_version: 20.05a + +stage_ivb: + diagnosis: + figo_stage: + description: >- + A FIGO stage term that applies to gynecologic cancers. For cervical cancer, + it refers to cancer with distant metastases, including peritoneal involvement, + involvement of the supraclavicular or mediastinal lymph nodes, and metastases + to the lung, bone, or liver; for endometrial cancer, it refers to cancer with + distant metastases, including metastases to the inguinal lymph nodes, intraperitoneal + involvement, or metastases to the lung, bone, or liver. Endometrial cancer + metastases to the para-aortic lymph nodes, vagina, adnexa, or pelvic serosa + are excluded from this stage. + termDef: + term: >- + FIGO Stage IVB + source: NCIt + cde_id: C96263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96263" + term_id: C96263 + term_version: 20.05a + masaoka_stage: + description: >- + The tumor shows lymphogenous or hematogenous metastasis to distant sites. + termDef: + term: >- + Masaoka-Koga Stage IVb + source: NCIt + cde_id: C112012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C112012" + term_id: C112012 + term_version: 20.05a + common: + description: >- + Cancer that has spread to distant anatomic sites beyond its original site of + growth. The definition of stage IVB depends on the particular type of cancer + that it refers to; for example, for bone cancer, stage IVB is defined as follows: + (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N1: Regional lymph node + metastasis. M1b: Metastasis to other distant sites; for vaginal cancer, stage + IVB is defined as follows: Any T, Any N, M1. M1: Distant metastasis. (partially + adapted from AJCC 7th ed.) + termDef: + term: >- + Stage IVB + source: NCIt + cde_id: C27980 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27980" + term_id: C27980 + term_version: 20.05a + +stage_ivc: + common: + description: >- + Cancer that has spread to distant anatomic sites beyond its original site of + growth. The definition of stage IVC depends on the particular type of cancer + that it refers to; for example, for head and neck carcinomas (lip and oral cavity + carcinoma, laryngeal carcinoma, nasal cavity and paranasal sinus carcinoma, + pharynx carcinoma, thyroid gland carcinoma, and major salivary gland carcinoma) + and head and neck mucosal melanoma, stage IVC is defined as follows: any T, + any N, M1; for appendix carcinoma, stage IVC is defined as follows: any T, any + N, M1b, any G. M1: Distant metastasis. M1b: Nonperitoneal metastasis. G: Grade + (cellular differentiation). + termDef: + term: >- + Stage IVC + source: NCIt + cde_id: C28055 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28055" + term_id: C28055 + term_version: 20.05a + +stage_tis: + common: + description: >- + A term that refers to a TNM finding of a primary tumor microscopically defined + as carcinoma in situ. + termDef: + term: >- + Tis Stage Finding + source: NCIt + cde_id: C48738 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48738" + term_id: C48738 + term_version: 20.05a + +stage_x: + common: + description: >- + A stage term that is applied to patients who have not been evaluated, but are + presumed to have cancer. + termDef: + term: >- + Stage X + source: NCIt + cde_id: C95957 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95957" + term_id: C95957 + term_version: 20.05a + +start_lost: + common: + description: >- + A mutation occurring within the start codon of a gene that results in a sequence + that no longer encodes a start codon. This can result in a gene deletion or + gene transcription may start from an alternative start site. + termDef: + term: >- + Start Lost Mutation + source: NCIt + cde_id: C148649 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148649" + term_id: C148649 + term_version: 20.10d + +stat3: + common: + description: >- + This gene plays a role in signal transduction and activation of transcription. + It is involved in regulation of both apoptosis and cell growth. + termDef: + term: >- + STAT3 Gene + source: NCIt + cde_id: C24833 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24833" + term_id: C24833 + term_version: 20.10d + +stat5b: + common: + description: >- + This gene is involved in signal transduction and activation of transcription. + It plays a role in the immune response via stimulation of T-cell proliferation. + termDef: + term: >- + STAT5B Gene + source: NCIt + cde_id: C28667 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28667" + term_id: C28667 + term_version: 20.10d + +stat6: + common: + description: >- + This gene plays a role in signal transduction and activation of transcription. + termDef: + term: >- + STAT6 Gene + source: NCIt + cde_id: C24835 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24835" + term_id: C24835 + term_version: 20.10d + +state_of_palestine: + common: + description: >- + A sovereign state in western Africa consisting of the West Bank and the Gaza + Strip. Its capital is Jerusalem. + termDef: + term: >- + State of Palestine + source: NCIt + cde_id: C20110 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20110" + term_id: C20110 + term_version: 19.12e + +stem_cell_leukemia: + common: + description: >- + A rare acute leukemia of ambiguous lineage in which the blasts do not express + markers specific to myeloid or lymphoid lineage. + termDef: + term: >- + Acute Undifferentiated Leukemia + source: NCIt + cde_id: C9298 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9298" + term_id: C9298 + term_version: 20.05a + +step_child: + common: + description: >- + A child of one's spouse, acquired through marriage. + termDef: + term: >- + Step Child + source: NCIt + cde_id: C166117 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166117" + term_id: C166117 + term_version: 19.12e + +step_sibling: + common: + description: >- + A child of one's step parent. + termDef: + term: >- + Step Sibling + source: NCIt + cde_id: C166118 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166118" + term_id: C166118 + term_version: 19.12e + +stepbrother: + common: + description: >- + A male child of one's step parent. + termDef: + term: >- + Stepbrother + source: NCIt + cde_id: C166119 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166119" + term_id: C166119 + term_version: 19.12e + +stepdaughter: + common: + description: >- + A female child of one's spouse, acquired through marriage. + termDef: + term: >- + Stepdaughter + source: NCIt + cde_id: C166123 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166123" + term_id: C166123 + term_version: 19.12e + +stepfather: + common: + description: >- + A male that is related to a child or children through marriage to their biological + parent. + termDef: + term: >- + Step Father + source: NCIt + cde_id: C154851 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154851" + term_id: C154851 + term_version: 19.12e + +stepmother: + common: + description: >- + A female who is married to a spouse with children whom are not biologically + related to her. + termDef: + term: >- + Stepmother + source: NCIt + cde_id: C132450 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C132450" + term_id: C132450 + term_version: 19.12e + +stepsister: + common: + description: >- + A female child of one's step parent. + termDef: + term: >- + Stepsister + source: NCIt + cde_id: C166124 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166124" + term_id: C166124 + term_version: 19.12e + +stepson: + common: + description: >- + A male child of one's spouse, acquired through marriage. + termDef: + term: >- + Stepson + source: NCIt + cde_id: C166125 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166125" + term_id: C166125 + term_version: 19.12e + +steroid_cell_tumor_nos: + common: + description: >- + An ovarian tumor in which the vast majority of the cells (more than 90% of the + tumor cells) resemble steroid hormone-secreting cells. It usually presents with + androgenic manifestations. Approximately one-third of the cases follow a malignant + clinical course. + termDef: + term: >- + Ovarian Steroid Cell Tumor + source: NCIt + cde_id: C4215 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4215" + term_id: C4215 + term_version: 20.05a + +stil: + common: + description: >- + This gene plays a role in both cellular proliferation and embryonic development. + termDef: + term: >- + STIL Gene + source: NCIt + cde_id: C101126 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101126" + term_id: C101126 + term_version: 20.10d + +sting_agonist_bms986301: + common: + description: >- + An agonist of stimulator of interferon genes (STING) protein, with potential + immunoactivating and antineoplastic activities. Upon administration, STING agonist + BMS-986301 targets and binds to STING and activates the STING pathway, which + promotes IKK-related kinase TANK-binding kinase 1 (TBK1) signaling and activates + nuclear factor-kappa B (NF-kB) and interferon regulatory factor 3 (IRF3) in + immune cells in the tumor microenvironment (TME). This leads to the production + of pro-inflammatory cytokines, including interferons (IFNs). Specifically, expression + of IFN-beta (IFNb) enhances the cross-presentation of tumor-associated antigens + (TAAs) by dendritic cells (DCs) to cytotoxic T-lymphocytes (CTLs). This results + in a CTL-mediated immune response against tumor cells and causes tumor cell + lysis. STING, a transmembrane protein that activates immune cells in the TME, + plays a key role in the activation of the innate immune system. + termDef: + term: >- + STING Agonist BMS-986301 + source: NCIt + cde_id: C167292 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167292" + term_id: C167292 + term_version: 20.10d + +sting_agonist_gsk3745417: + common: + description: >- + An agonist of the stimulator of interferon genes protein (STING; transmembrane + protein 173; TMEM173), with potential immunoactivating and antineoplastic activities. + Upon intravenous administration, STING agonist GSK3745417 targets and binds + to STING and activates the STING pathway in immune cells in the tumor microenvironment + (TME). This leads to the production of pro-inflammatory cytokines, including + interferons (IFNs), enhances the cross-presentation of tumor-associated antigens + (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated + immune response against cancer cells. STING, a transmembrane protein that activates + immune cells in the TME, plays a key role in the activation of the innate immune + system. + termDef: + term: >- + STING Agonist GSK3745417 + source: NCIt + cde_id: C165748 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165748" + term_id: C165748 + term_version: 20.10d + +sting_agonist_imsa101: + common: + description: >- + A small molecule analogue of cyclic GMP-AMP (cGAMP) that acts as an agonist + of the stimulator of interferon genes protein (STING; transmembrane protein + 173; TMEM173) with potential immunoactivating and antineoplastic activities. + Upon intratumoral administration, STING agonist IMSA101 binds to STING and activates + STING-mediated pathways. This activates the immune response through the activation + of certain immune cells which induces the expression of pro-inflammatory cytokines + and chemokines, promotes tumor-associated antigen (TAA) processing and presentation + by dendritic cells (DCs) and leads to an antigen-specific T-cell mediated immune + response against cancer cells. STING, a transmembrane protein that activates + immune cells in the tumor microenvironment, plays a key role in the activation + of the innate immune system. + termDef: + term: >- + STING Agonist IMSA101 + source: NCIt + cde_id: C165655 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165655" + term_id: C165655 + term_version: 20.10d + +sting_agonist_sb_11285: + common: + description: >- + An agonist of stimulator of interferon genes (STING) protein, with potential + immunoactivating and antineoplastic activities. Upon intravenous administration, + STING agonist SB 11285 targets and binds to STING and activates the STING pathway, + which promotes IKK-related kinase TANK-binding kinase 1 (TBK1) signaling and + activates nuclear factor-kappa B (NF-kB) and interferon regulatory factor 3 + (IRF3) in immune cells in the tumor microenvironment (TME). This leads to the + production of pro-inflammatory cytokines, including interferons (IFNs). Specifically, + expression of IFN-beta (IFNb) enhances the cross-presentation of tumor-associated + antigens (TAAs) by CD8alpha-positive and CD103-positive dendritic cells (DCs) + to cytotoxic T-lymphocytes (CTLs). This results in a CTL-mediated immune response + against tumor cells and causes tumor cell lysis. + termDef: + term: >- + STING Agonist SB 11285 + source: NCIt + cde_id: C165566 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165566" + term_id: C165566 + term_version: 20.10d + +sting_agonist_tak676: + common: + description: >- + An agonist of the stimulator of interferon genes protein (STING; transmembrane + protein 173; TMEM173), with potential immunoactivating and antineoplastic activities. + Upon intravenous administration, STING agonist TAK-676 targets and binds to + STING and activates the STING pathway in immune cells in the tumor microenvironment + (TME). This leads to the production of pro-inflammatory cytokines, including + interferons (IFNs), enhances the cross-presentation of tumor-associated antigens + (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated + immune response against cancer cells. STING, a transmembrane protein that activates + immune cells in the TME, plays a key role in the activation of the innate immune + system. + termDef: + term: >- + STING Agonist TAK-676 + source: NCIt + cde_id: C173377 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173377" + term_id: C173377 + term_version: 20.10d + +stingexpressing_e_coli_synb1891: + common: + description: >- + A non-pathogenic strain of Escherichia coli (E. coli) bacteria that has been + engineered to express stimulator of interferon genes (STING; transmembrane protein + 173; TMEM173) protein, with potential immunoactivating and antineoplastic activities. + Upon intratumoral administration, STING-expressing E. coli SYNB1891 are engulfed + by antigen presenting cells (APCs) within the tumor. STING-mediated pathways + within the APCs are then activated resulting in a type I interferon (IFN) response + which promotes initiation and propagation of tumor-specific T-cell responses. + In addition, the bacterial component of SYNB1891 may further stimulate the innate + immune system via Toll-like receptors (TLRs) which may enhance the magnitude + of the overall immune response. STING, a transmembrane protein that activates + immune cells in the tumor microenvironment (TME), plays a key role in the activation + of the innate immune system. + termDef: + term: >- + STING-expressing E. coli SYNB1891 + source: NCIt + cde_id: C167270 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167270" + term_id: C167270 + term_version: 20.10d + +stk11: + common: + description: >- + This gene plays a role in cell cycle regulation. It is also putatively involved + in glucose production. + termDef: + term: >- + STK11 Gene + source: NCIt + cde_id: C18253 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18253" + term_id: C18253 + term_version: 20.10d + +stomach_nos: + common: + description: >- + An organ located under the diaphragm, between the liver and the spleen as well + as between the esophagus and the small intestine. The stomach is the primary + organ of food digestion. + termDef: + term: >- + Stomach + source: NCIt + cde_id: C12391 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12391" + term_id: C12391 + term_version: 20.05a + +stop_gain: + common: + description: >- + A point mutation occurring within the protein-coding region of a gene, and which + codes for a stop that can truncate the protein. + termDef: + term: >- + Nonsense Mutation + source: NCIt + cde_id: C62198 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62198" + term_id: C62198 + term_version: 20.10d + +stop_lost: + common: + description: >- + A mutation occurring within the stop codon of a gene that results in a sequence + that no longer encodes a stop codon and results in the transcription of non-coding + regions downstream of the gene. + termDef: + term: >- + Nonstop Mutation + source: NCIt + cde_id: C148650 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148650" + term_id: C148650 + term_version: 20.10d + +stop_retained_variant: + common: + description: >- + A mutation occurring within the stop codon of a gene, which still encodes a + stop codon. + termDef: + term: >- + Silent Stop Codon Mutation + source: NCIt + cde_id: C148651 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148651" + term_id: C148651 + term_version: 20.10d + +strn: + common: + description: >- + This gene may play a role in cell scaffolding or calcium signaling. + termDef: + term: >- + STRN Gene + source: NCIt + cde_id: C107661 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107661" + term_id: C107661 + term_version: 20.10d + +stromal_endometriosis: + common: + description: >- + An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, + and the ovary. It is characterized by the presence of oval to spindle-shape + cells that resemble the cells of the endometrial stroma, without evidence of + significant atypia and pleomorphism. Numerous small vessels are also present. + It is usually characterized by indolent growth and late recurrences. + termDef: + term: >- + Low Grade Endometrioid Stromal Sarcoma + source: NCIt + cde_id: C4263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4263" + term_id: C4263 + term_version: 20.05a + +stromal_myosis_nos: + common: + description: >- + An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, + and the ovary. It is characterized by the presence of oval to spindle-shape + cells that resemble the cells of the endometrial stroma, without evidence of + significant atypia and pleomorphism. Numerous small vessels are also present. + It is usually characterized by indolent growth and late recurrences. + termDef: + term: >- + Low Grade Endometrioid Stromal Sarcoma + source: NCIt + cde_id: C4263 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4263" + term_id: C4263 + term_version: 20.05a + +stromal_sarcoma_nos: + common: + description: >- + A malignant neoplasm characterized by the presence of atypical mesenchymal-stromal + cells. Representative examples include endometrial stromal sarcoma and prostate + stromal sarcoma. + termDef: + term: >- + Stromal Sarcoma + source: NCIt + cde_id: C6926 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6926" + term_id: C6926 + term_version: 20.05a + +stromal_tumor_benign: + common: + description: >- + A benign neoplasm composed of mesenchymal stromal cells without evidence of + cellular atypia. + termDef: + term: >- + Benign Stromal Tumor + source: NCIt + cde_id: C66772 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66772" + term_id: C66772 + term_version: 20.05a + +stromal_tumor_nos: + common: + description: >- + A benign or malignant mesenchymal neoplasm composed of stromal cells. Representative + examples include gastrointestinal stromal tumor, endometrial stromal sarcoma, + and prostate stromal sarcoma. + termDef: + term: >- + Stromal Neoplasm + source: NCIt + cde_id: C6781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6781" + term_id: C6781 + term_version: 20.05a + +stromal_tumor_with_minor_sex_cord_elements: + common: + description: >- + A rare, benign sex cord-stromal tumor of the ovary characterized by the presence + of a fibrothecomatous stroma and scattered sex cord elements. Although it is + usually hormonally inactive, cases associated with endometrial hyperplasia or + adenocarcinoma have been reported. + termDef: + term: >- + Ovarian Stromal Tumor with Minor Sex Cord Elements + source: NCIt + cde_id: C66749 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66749" + term_id: C66749 + term_version: 20.05a + +struma_ovarii_and_carcinoid: + common: + description: >- + An ovarian neoplasm characterized by the presence of aberrant thyroid tissue + and a carcinoid tumor. A minority of patients develop symptoms of functioning + thyroid tissue. The neuroendocrine carcinoid cells infiltrate the aberrant thyroid + tissue and progressively replace the follicular lining cells. + termDef: + term: >- + Strumal Carcinoid + source: NCIt + cde_id: C4292 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4292" + term_id: C4292 + term_version: 20.05a + +struma_ovarii_malignant: + common: + description: >- + An ovarian mature teratoma characterized by the presence of aberrant thyroid + tissue with morphologic changes identical to thyroid carcinoma. Patients may + present with abdominal mass and unusual symptoms due to thyrotoxicosis, or with + Meigs syndrome (ascites and pleural effusion). + termDef: + term: >- + Malignant Struma Ovarii + source: NCIt + cde_id: C4291 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4291" + term_id: C4291 + term_version: 20.05a + +struma_ovarii_nos: + common: + description: >- + An ovarian mature teratoma characterized by the presence of aberrant thyroid + tissue. The aberrant thyroid tissue shows morphologic changes identical to thyroid + adenoma or carcinoma. Patients may present with abdominal mass and unusual symptoms + due to thyrotoxicosis, or Meigs syndrome (ascites and pleural effusion). + termDef: + term: >- + Struma Ovarii + source: NCIt + cde_id: C7468 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7468" + term_id: C7468 + term_version: 20.05a + +strumal_carcinoid: + common: + description: >- + An ovarian neoplasm characterized by the presence of aberrant thyroid tissue + and a carcinoid tumor. A minority of patients develop symptoms of functioning + thyroid tissue. The neuroendocrine carcinoid cells infiltrate the aberrant thyroid + tissue and progressively replace the follicular lining cells. + termDef: + term: >- + Strumal Carcinoid + source: NCIt + cde_id: C4292 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4292" + term_id: C4292 + term_version: 20.05a + +subacute_granulocytic_leukemia: + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm characterized by the principal + involvement of the neutrophil series with leukocytosis and multilineage dysplasia. The + neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion + gene. (WHO, 2001) + termDef: + term: >- + Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative + source: NCIt + cde_id: C3519 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3519" + term_id: C3519 + term_version: 20.05a + +subacute_myelogenous_leukemia: + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm characterized by the principal + involvement of the neutrophil series with leukocytosis and multilineage dysplasia. The + neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion + gene. (WHO, 2001) + termDef: + term: >- + Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative + source: NCIt + cde_id: C3519 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3519" + term_id: C3519 + term_version: 20.05a + +subacute_myeloid_leukemia: + common: + description: >- + A myelodysplastic/myeloproliferative neoplasm characterized by the principal + involvement of the neutrophil series with leukocytosis and multilineage dysplasia. The + neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion + gene. (WHO, 2001) + termDef: + term: >- + Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative + source: NCIt + cde_id: C3519 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3519" + term_id: C3519 + term_version: 20.05a + +subareolar_duct_papillomatosis: + common: + description: >- + A benign epithelial neoplasm arising from the nipple. Signs and symptoms include + serous or sanguineous nipple discharge and nipple erosion. It is characterized + by the presence of aggregates of small tubules replacing the nipple stroma. + The tubules are lined by epithelial and myoepithelial cells. + termDef: + term: >- + Nipple Adenoma + source: NCIt + cde_id: C4192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4192" + term_id: C4192 + term_version: 20.05a + +subcutaneous_panniculitislike_tcell_lymphoma: + common: + description: >- + A cytotoxic primary cutaneous T-cell lymphoma. Recent studies suggest there + are at least two groups of subcutaneous panniculitis-like T-cell lymphomas, + each with distinct histologic features, immunophenotypic profile, and prognosis. + One group has an alpha/beta, CD8 positive phenotype, involves only subcutaneous + tissues, and usually has an indolent clinical course. The second group has a + gamma/delta phenotype, is CD8 negative, often co-expresses CD56, is not confined + to the subcutaneous tissues, and usually has a poor prognosis. In the recent + WHO-EORTC classification, the term subcutaneous panniculitis-like T-cell lymphoma + is reserved for cases with an alpha/beta, CD8 positive phenotype. Cases with + a gamma/delta phenotype are included in the group of cutaneous gamma/delta T-cell + lymphomas. + termDef: + term: >- + Subcutaneous Panniculitis-Like T-Cell Lymphoma + source: NCIt + cde_id: C6918 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6918" + term_id: C6918 + term_version: 20.05a + +subependymal_giant_cell_astrocytoma: + common: + description: >- + A benign, slowly growing tumor (WHO grade I) typically arising in the wall of + the lateral ventricles and composed of large ganglioid astrocytes. It is the + most common CNS neoplasm in patients with tuberous sclerosis complex and typically + occurs during the first two decades of life. (WHO) + termDef: + term: >- + Subependymal Giant Cell Astrocytoma + source: NCIt + cde_id: C3696 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3696" + term_id: C3696 + term_version: 20.05a + +subependymal_glioma: + common: + description: >- + A benign, slow growing neoplasm which is typically attached to a ventricular + wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary + matrix with frequent microcystic change. Some lesions have the histological + features of both subependymoma and ependymoma. It is often detected incidentally + and has a very favorable prognosis. (Adapted from WHO.) + termDef: + term: >- + Subependymoma + source: NCIt + cde_id: C3795 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3795" + term_id: C3795 + term_version: 20.05a + +subependymoma: + common: + description: >- + A benign, slow growing neoplasm which is typically attached to a ventricular + wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary + matrix with frequent microcystic change. Some lesions have the histological + features of both subependymoma and ependymoma. It is often detected incidentally + and has a very favorable prognosis. (Adapted from WHO.) + termDef: + term: >- + Subependymoma + source: NCIt + cde_id: C3795 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3795" + term_id: C3795 + term_version: 20.05a + +subepidermal_nodular_fibrosis: + common: + description: >- + Subepidermal Nodular Fibrosis + termDef: + term: >- + Subepidermal Nodular Fibrosis + source: NCIt + cde_id: C7159 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7159" + term_id: C7159 + term_version: 20.05a + +subglottis: + common: + description: >- + The area of the larynx below the vocal cords down to the trachea. + termDef: + term: >- + Subglottis + source: NCIt + cde_id: C12280 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12280" + term_id: C12280 + term_version: 20.05a + +sublingual_gland: + common: + description: >- + A salivary gland located under the tongue in the floor of the oral cavity. + termDef: + term: >- + Sublingual Salivary Gland + source: NCIt + cde_id: C12234 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12234" + term_id: C12234 + term_version: 20.05a + +submandibular: + common: + description: >- + A lymph node located beneath the floor of the oral cavity. + termDef: + term: >- + Submandibular Lymph Node + source: NCIt + cde_id: C77650 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C77650" + term_id: C77650 + term_version: 20.10d + +submandibular_gland: + common: + description: >- + One of a pair of major salivary glands located below the floor of the mouth. + termDef: + term: >- + Submandibular Gland + source: NCIt + cde_id: C12233 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12233" + term_id: C12233 + term_version: 20.05a + +substitution: + common: + description: >- + A point mutation occurring within the protein-coding region of a gene, and which + codes for a different amino acid than expected. + termDef: + term: >- + Missense Mutation + source: NCIt + cde_id: C18133 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18133" + term_id: C18133 + term_version: 20.10d + +sudan: + common: + description: >- + A country in northeastern Africa, bordering the Red Sea, between Egypt and Eritrea. + termDef: + term: >- + Sudan + source: NCIt + cde_id: C17170 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17170" + term_id: C17170 + term_version: 19.12e + +sufu: + common: + description: >- + This gene plays a role in the regulation of both transcription and signaling. + termDef: + term: >- + SUFU Gene + source: NCIt + cde_id: C97819 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97819" + term_id: C97819 + term_version: 20.10d + +sugemalimab: + common: + description: >- + A fully human monoclonal antibody directed against the immunosuppressive ligand, + programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), + with potential immune checkpoint inhibitory and antineoplastic activities. Upon + administration, sugemalimab specifically targets and binds to PD-L1, blocking + its binding to and activation of its receptor, programmed cell death 1 (PD-1). + This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances + the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against + PD-L1-expressing tumor cells. PD-L1 is overexpressed by many human cancer cell + types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results + in immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin + superfamily expressed on activated T-cells, is a negative regulator of the immune + system that limits the expansion and survival of CD8-positive T-cells. Anti-PD-L1 + monoclonal antibody CS1001 mirrors natural immunoglobulin G4 (IgG4), potentially + reducing immunogenicity and other toxicities. + termDef: + term: >- + Sugemalimab + source: NCIt + cde_id: C154550 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154550" + term_id: C154550 + term_version: 20.10d + +superficial_spreading_adenocarcinoma: + common: + description: >- + An adenocarcinoma which has spread within the mucosa without further invasion + of the underlying tissues. + termDef: + term: >- + Superficial Spreading Adenocarcinoma + source: NCIt + cde_id: C4125 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4125" + term_id: C4125 + term_version: 20.05a + +superficial_spreading_melanoma: + common: + description: >- + A type of melanoma that typically occurs in light-skinned individuals ranging + in age from young adults to the elderly. Risk factors include extensive sun + exposure during childhood, a family history of melanoma, and the presence of + dysplastic nevi. + termDef: + term: >- + Low-CSD Melanoma + source: NCIt + cde_id: C9152 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9152" + term_id: C9152 + term_version: 20.05a + +superficial_well_differentiated_liposarcoma: + common: + description: >- + An intermediate, locally aggressive lipomatous neoplasm. Microscopically, the + adipose tissue contains large and pleomorphic lipoblasts, and is dissected by + fibrous septa containing spindle cells. It requires a wide local excision, + may recur locally, but never metastasizes. + termDef: + term: >- + Atypical Lipomatous Tumor + source: NCIt + cde_id: C6505 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6505" + term_id: C6505 + term_version: 20.05a + +superior_wall_of_nasopharynx: + common: + description: >- + The roof of the nasopharynx. + termDef: + term: >- + Superior Wall of the Nasopharynx + source: NCIt + cde_id: C12242 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12242" + term_id: C12242 + term_version: 20.05a + +superoxide_dismutase_mimetic_gc4711: + common: + description: >- + A mimetic of the enzyme superoxide dismutase (SOD) that may potentially be used + to increase the anti-cancer efficacy of stereotactic body radiation therapy + (SBRT). Upon administration, SOD mimetic GC4711 may mimic native SODs and catalyze + the formation of molecular oxygen and hydrogen peroxide from the burst of superoxide + anion present in the irradiated tissues upon radiation. As hydrogen peroxide + is less toxic than superoxide to normal tissues, but more toxic to cancer cells, + this may increase the anti-cancer efficacy of SBRT and decrease its damage to + normal tissues. + termDef: + term: >- + Superoxide Dismutase Mimetic GC4711 + source: NCIt + cde_id: C173664 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173664" + term_id: C173664 + term_version: 20.10d + +supraclavicular: + common: + description: >- + A lymph node which is located above the clavicle. + termDef: + term: >- + Supraclavicular Lymph Node + source: NCIt + cde_id: C12903 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12903" + term_id: C12903 + term_version: 20.10d + +supraglottis: + common: + description: >- + The upper part of the larynx, including the epiglottis; the area above the vocal + cords. + termDef: + term: >- + Supraglottis + source: NCIt + cde_id: C12279 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12279" + term_id: C12279 + term_version: 20.05a + +supratentorial_pnet: + common: + description: >- + A central nervous system embryonal tumor, not otherwise specified arising from + the supratentorial region. + termDef: + term: >- + Supratentorial Embryonal Tumor, Not Otherwise Specified + source: NCIt + cde_id: C6968 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6968" + term_id: C6968 + term_version: 20.05a + +surgical_complications: + common: + description: >- + A disease or disorder that occurs during, soon after or as a result of a surgical + procedure. + termDef: + term: >- + Surgical Complication + source: NCIt + cde_id: C164157 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C34735" + term_id: C164157 + term_version: 19.12e + +surgical_resection: + common: + description: >- + The act of cutting out; the surgical removal of part or all of a structure or + organ. + termDef: + term: >- + Excision + source: NCIt + cde_id: C15232 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15232" + term_id: C15232 + term_version: 20.05a + +suriname: + common: + description: >- + A country in northern South America, bordering the North Atlantic Ocean, between + French Guiana and Guyana. + termDef: + term: >- + Suriname + source: NCIt + cde_id: C17175 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17175" + term_id: C17175 + term_version: 19.12e + +suz12: + common: + description: >- + This gene plays a role in embryonic development and histone methylation. + termDef: + term: >- + SUZ12 Gene + source: NCIt + cde_id: C73545 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73545" + term_id: C73545 + term_version: 20.10d + +svalbard__jan_mayen_islands: + common: + description: >- + A group of islands between the Arctic Ocean, Barents Sea, Greenland Sea, and + Norwegian Sea, northeast of Iceland and north of Norway. + termDef: + term: >- + Svalbard and Jan Mayen + source: NCIt + cde_id: C17178 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17178" + term_id: C17178 + term_version: 19.12e + +sweat_gland_adenocarcinoma: + common: + description: >- + A carcinoma arising from the sweat glands. Representative examples include tubular + carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine + carcinoma. + termDef: + term: >- + Sweat Gland Carcinoma + source: NCIt + cde_id: C6938 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6938" + term_id: C6938 + term_version: 20.05a + +sweat_gland_adenoma: + common: + description: >- + A benign epithelial neoplasm arising from the sweat glands. Representative examples + include tubular apocrine adenoma, syringofibroadenoma, and hidradenoma. + termDef: + term: >- + Sweat Gland Adenoma + source: NCIt + cde_id: C7560 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7560" + term_id: C7560 + term_version: 20.05a + +sweat_gland_carcinoma: + common: + description: >- + A carcinoma arising from the sweat glands. Representative examples include tubular + carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine + carcinoma. + termDef: + term: >- + Sweat Gland Carcinoma + source: NCIt + cde_id: C6938 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6938" + term_id: C6938 + term_version: 20.05a + +sweat_gland_tumor_benign: + common: + description: >- + A benign neoplasm involving the sweat gland. + termDef: + term: >- + Benign Sweat Gland Neoplasm + source: NCIt + cde_id: C4879 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4879" + term_id: C4879 + term_version: 20.05a + +sweat_gland_tumor_malignant: + common: + description: >- + A malignant neoplasm that affects the sweat glands. + termDef: + term: >- + Malignant Sweat Gland Neoplasm + source: NCIt + cde_id: C4810 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4810" + term_id: C4810 + term_version: 20.05a + +sweat_gland_tumor_nos: + common: + description: >- + A benign or malignant neoplasm arising from the sweat glands. + termDef: + term: >- + Sweat Gland Neoplasm + source: NCIt + cde_id: C3398 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3398" + term_id: C3398 + term_version: 20.05a + +sweden: + common: + description: >- + A country in northern Europe, bordering the Baltic Sea, between Finland and + Norway. + termDef: + term: >- + Sweden + source: NCIt + cde_id: C17180 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17180" + term_id: C17180 + term_version: 19.12e + +switzerland: + common: + description: >- + A country in central Europe, east of France and north of Italy. + termDef: + term: >- + Switzerland + source: NCIt + cde_id: C17181 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17181" + term_id: C17181 + term_version: 19.12e + +syk: + common: + description: >- + This gene plays a role in receptor tyrosine phosphorylation signal transduction, + phagocytosis, endothelial cell growth and proliferation. + termDef: + term: >- + SYK Gene + source: NCIt + cde_id: C26536 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26536" + term_id: C26536 + term_version: 20.10d + +sympathetic_paraganglioma: + common: + description: >- + A benign or malignant paraganglioma arising from the chromaffin cells of the + paraganglia that are located along the sympathetic nerves. It includes extra-adrenal + paragangliomas and paragangliomas that arise from the adrenal medulla. The + latter are commonly referred to as pheochromocytomas. Representative examples + of extra-adrenal sympathetic paragangliomas include the bladder, and superior + and inferior paraaortic paragangliomas. Clinical signs are related to the secretion + of catecholamines resulting in hypertension. + termDef: + term: >- + Sympathetic Paraganglioma + source: NCIt + cde_id: C4216 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4216" + term_id: C4216 + term_version: 20.05a + +symplastic_leiomyoma: + common: + description: >- + A morphologic variant of leiomyoma characterized by the presence of pleomorphic + muscle cells with bizarre hyperchromatic nuclei and eosinophilic cytoplasm. + termDef: + term: >- + Bizarre Leiomyoma + source: NCIt + cde_id: C4257 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4257" + term_id: C4257 + term_version: 20.05a + +syncytial_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the presence of tumor cells that form + lobules. The tumor cells are generally uniform. Whorls and psammoma bodies are + usually not present. + termDef: + term: >- + Meningothelial Meningioma + source: NCIt + cde_id: C4329 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4329" + term_id: C4329 + term_version: 20.05a + +synonymous_variant: + common: + description: >- + A point mutation occurring within the protein-coding region of a gene, and which + codes for the same amino acid as expected. + termDef: + term: >- + Silent Mutation + source: NCIt + cde_id: C20629 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20629" + term_id: C20629 + term_version: 20.10d + +synovial_sarcoma_biphasic: + common: + description: >- + A synovial sarcoma characterized by the presence of both an epithelial and a + spindle cell component. + termDef: + term: >- + Biphasic Synovial Sarcoma + source: NCIt + cde_id: C4279 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4279" + term_id: C4279 + term_version: 20.05a + +synovial_sarcoma_epithelioid_cell: + common: + description: >- + A synovial sarcoma characterized by the presence of an epithelial cell component + only. The epithelial cells are arranged in glandular or papillary structures. + termDef: + term: >- + Epithelial Synovial Sarcoma + source: NCIt + cde_id: C4278 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4278" + term_id: C4278 + term_version: 20.05a + +synovial_sarcoma_monophasic_fibrous: + common: + description: >- + A synovial sarcoma characterized by the presence of a spindle cell component + only. + termDef: + term: >- + Spindle Cell Synovial Sarcoma + source: NCIt + cde_id: C4277 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4277" + term_id: C4277 + term_version: 20.05a + +synovial_sarcoma_nos: + common: + description: >- + A malignant neoplasm characterized by the chromosomal translocation t(X;18)(p11;q11). It + can occur at any age, but mainly affects young adults, more commonly males. Although + any site can be affected, the vast majority of the cases arise in the deep soft + tissues of extremities, especially around the knee. Microscopically, synovial + sarcoma is classified as monophasic (with a spindle or epithelial cell component) + or biphasic (with both spindle and epithelial cell components). Synovial sarcomas + can recur or metastasize to the lungs, bones, and lymph nodes. + termDef: + term: >- + Synovial Sarcoma + source: NCIt + cde_id: C3400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3400" + term_id: C3400 + term_version: 20.05a + +synovial_sarcoma_spindle_cell: + common: + description: >- + A synovial sarcoma characterized by the presence of a spindle cell component + only. + termDef: + term: >- + Spindle Cell Synovial Sarcoma + source: NCIt + cde_id: C4277 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4277" + term_id: C4277 + term_version: 20.05a + +synovioma_benign: + common: + description: >- + A benign neoplasm arising from the synovial membrane. Examples include the + diffuse giant cell tumor of tendon sheath and localized giant cell tumor of + tendon sheath. + termDef: + term: >- + Benign Synovial Neoplasm + source: NCIt + cde_id: C3829 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3829" + term_id: C3829 + term_version: 20.05a + +synovioma_malignant: + common: + description: >- + A malignant neoplasm characterized by the chromosomal translocation t(X;18)(p11;q11). It + can occur at any age, but mainly affects young adults, more commonly males. Although + any site can be affected, the vast majority of the cases arise in the deep soft + tissues of extremities, especially around the knee. Microscopically, synovial + sarcoma is classified as monophasic (with a spindle or epithelial cell component) + or biphasic (with both spindle and epithelial cell components). Synovial sarcomas + can recur or metastasize to the lungs, bones, and lymph nodes. + termDef: + term: >- + Synovial Sarcoma + source: NCIt + cde_id: C3400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3400" + term_id: C3400 + term_version: 20.05a + +synovioma_nos: + common: + description: >- + A malignant neoplasm characterized by the chromosomal translocation t(X;18)(p11;q11). It + can occur at any age, but mainly affects young adults, more commonly males. Although + any site can be affected, the vast majority of the cases arise in the deep soft + tissues of extremities, especially around the knee. Microscopically, synovial + sarcoma is classified as monophasic (with a spindle or epithelial cell component) + or biphasic (with both spindle and epithelial cell components). Synovial sarcomas + can recur or metastasize to the lungs, bones, and lymph nodes. + termDef: + term: >- + Synovial Sarcoma + source: NCIt + cde_id: C3400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3400" + term_id: C3400 + term_version: 20.05a + +synthetic_plumbagin_pcur101: + common: + description: >- + A synthetic form of the plant-derived medicinal agent, plumbagin, with potential + antineoplastic activity. Plumbagin may act by inhibiting the expression of + protein kinase C epsilon (PKCe), signal transducers and activators of transcription + 3 phosphorylation (Stat3), protein kinase B (AKT), and certain epithelial-to-mesenchymal + transition (EMT) markers, including vimentin and slug. This results in possible + inhibition of proliferation in susceptible tumor cells. PKCe, Stat3, AKT, and + the EMT markers vimentin and slug have been linked to the induction and progression + of prostate cancer. + termDef: + term: >- + Synthetic Plumbagin PCUR-101 + source: NCIt + cde_id: C166377 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166377" + term_id: C166377 + term_version: 20.10d + +syp: + common: + description: >- + This gene is involved in vesicle targeting and synaptic plasticity. + termDef: + term: >- + SYP Gene + source: NCIt + cde_id: C101144 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101144" + term_id: C101144 + term_version: 20.10d + +syria: + common: + description: >- + A country in the Middle East, bordering the Mediterranean Sea, between Lebanon + and Turkey. + termDef: + term: >- + Syria + source: NCIt + cde_id: C17182 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17182" + term_id: C17182 + term_version: 19.12e + +syringocystadenoma_papilliferum: + common: + description: >- + A benign adnexal neoplasm occurring during childhood or adolescence. It usually + presents as a papular lesion or a plaque on the head and neck. It may arise + in an organoid nevus such as sebaceous. It is characterized by an endophytic + invagination of the epithelium into the dermis. There are dermal cystic spaces + present, containing villous projections. Complete excision is curative. + termDef: + term: >- + Syringocystadenoma Papilliferum + source: NCIt + cde_id: C4172 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4172" + term_id: C4172 + term_version: 20.05a + +syringofibroadenoma: + common: + description: >- + A rare, benign eccrine neoplasm usually arising on acral areas as a solitary + papular or nodular lesion. Multiple lesions are referred as syringofibroadenomatosis. + It is characterized by the presence of epithelial cuboidal cells forming anastomosing + cords in a fibrovascular stroma. + termDef: + term: >- + Syringofibroadenoma + source: NCIt + cde_id: C43356 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43356" + term_id: C43356 + term_version: 20.05a + +syringoma_nos: + common: + description: >- + A benign sweat gland neoplasm usually affecting the lower eyelids and upper + cheeks. The lesions are papular and are usually numerous. Morphologically, there + are nests, cords, and tubules of epithelial cells present, surrounded by a dense + stroma in the reticular dermis. + termDef: + term: >- + Syringoma + source: NCIt + cde_id: C3761 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3761" + term_id: C3761 + term_version: 20.05a + +syringomatous_carcinoma: + common: + description: >- + A low grade adenocarcinoma with ductal differentiation, arising from the sweat + glands. It presents as a scar usually in the face. It is characterized by the + formation of small ducts and it frequently involves nerves and perineural spaces. + termDef: + term: >- + Microcystic Adnexal Carcinoma + source: NCIt + cde_id: C7581 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7581" + term_id: C7581 + term_version: 20.05a + +systemic_ebv_positive_tcell_lymphoproliferative_disease_of_childhood: + common: + description: >- + An aggressive and life-threatening, EBV-positive T-cell lymphoma affecting children. It + is more prevalent in Taiwan and Japan. Clinically, it presents with acute onset + of fever and generalized malaise, followed by hepatosplenomegaly and liver failure. Morphologically + it is characterized by the presence of infiltrating T-lymphocytes which are + usually small and erythrophagocytosis. Most patients have a fulminant clinical + course. + termDef: + term: >- + Systemic EBV-Positive T-Cell Lymphoma of Childhood + source: NCIt + cde_id: C80374 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80374" + term_id: C80374 + term_version: 20.05a + +systemic_light_chain_disease: + common: + description: >- + A condition in which plasma cells secrete immunoglobulin light chains of only + one type, kappa or lambda. Light chain deposition disease is often associated + with multiple myeloma or lymphoproliferative disease, but as many as 50% of + patients have no evidence of neoplastic plasma cell proliferation. Light chains + excreted in the urine are known as Bence Jones protein. Amyloidosis and severe + renal failure occur more frequently than in multiple myeloma. Also known as + Bence Jones myeloma. L-chain disease, L-chain myeloma, and LCDD. + termDef: + term: >- + Light Chain Deposition Disease + source: NCIt + cde_id: C7727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7727" + term_id: C7727 + term_version: 20.05a + +systemic_mastocytosis_with_ahnmd: + common: + description: >- + A disorder characterized by systemic infiltration of internal organs by aggregates + of neoplastic mast cells and the presence of a clonal non-mast cell hematologic + neoplasm (e.g., myelodysplastic syndrome, chronic myeloproliferative disorder, + acute myeloid leukemia, and lymphoma). + termDef: + term: >- + Systemic Mastocytosis with an Associated Hematological Neoplasm + source: NCIt + cde_id: C9284 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9284" + term_id: C9284 + term_version: 20.05a + +systemic_mastocytosis_with_associated_hematological_clonal_nonmast_cell_disorder: + common: + description: >- + A disorder characterized by systemic infiltration of internal organs by aggregates + of neoplastic mast cells and the presence of a clonal non-mast cell hematologic + neoplasm (e.g., myelodysplastic syndrome, chronic myeloproliferative disorder, + acute myeloid leukemia, and lymphoma). + termDef: + term: >- + Systemic Mastocytosis with an Associated Hematological Neoplasm + source: NCIt + cde_id: C9284 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9284" + term_id: C9284 + term_version: 20.05a + +systemic_tissue_mast_cell_disease: + common: + description: >- + A variant of mastocytosis characterized by multifocal, dense infiltrates of + mast cells (15 or more mast cells in aggregates) detected in the bone marrow + and/or other extracutaneous sites. (WHO, 2001) + termDef: + term: >- + Systemic Mastocytosis + source: NCIt + cde_id: C9235 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9235" + term_id: C9235 + term_version: 20.05a + +t_lymphoblastic_leukemialymphoma: + common: + description: >- + A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed + of small to medium-sized blast cells. When the neoplasm involves predominantly + the bone marrow and the peripheral blood, it is called T acute lymphoblastic + leukemia. When it involves nodal or extranodal sites it is called T lymphoblastic + lymphoma. (WHO, 2001) + termDef: + term: >- + T Lymphoblastic Leukemia/Lymphoma + source: NCIt + cde_id: C8694 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8694" + term_id: C8694 + term_version: 20.05a + +t0: + common: + description: >- + A primary tumor TNM finding indicating that there is no evidence of primary + tumor. + termDef: + term: >- + T0 Stage Finding + source: NCIt + cde_id: C48719 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48719" + term_id: C48719 + term_version: 20.05a + +t1: + common: + description: >- + A clinical and/or pathologic primary tumor TNM finding indicating that the cancer + is limited to the site of growth. + termDef: + term: >- + T1 Stage Finding + source: NCIt + cde_id: C48720 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48720" + term_id: C48720 + term_version: 20.05a + diagnosis: + ensat_pathologic_t: + description: >- + Adrenal cancer with tumor size equal or less than 5.0 cm. There is no invasion + of tissues outside the adrenal gland. (7th Ed, 2009) + termDef: + term: >- + pT1 ENSAT Staging Finding v7 + source: NCIt + cde_id: C104019 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104019" + term_id: C104019 + term_version: 23.03d + +t1a: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor limited to the + site of growth. The definition of T1a TNM finding depends on the specific type + of cancer that it refers to; for example, for breast cancer it refers to a primary + tumor that is more than 0.1cm, but not more than 0.5 cm in greatest dimension; + for kidney cancer it refers to a primary tumor that is 4 cm or less in greatest + dimension; and for thyroid cancer it refers to a primary tumor that is 1 cm + or less in greatest dimension. + termDef: + term: >- + T1a Stage Finding + source: NCIt + cde_id: C48721 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48721" + term_id: C48721 + term_version: 20.05a + +t1a1: + common: + description: >- + Invasive cervical carcinoma with measured stromal invasion of 3.0 mm or less + in depth and 7.0 mm or less in horizontal spread. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer pT1a1 TNM Finding v8 + source: NCIt + cde_id: C139711 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139711" + term_id: C139711 + term_version: 20.05a + +t1a2: + common: + description: >- + Invasive cervical carcinoma with measured stromal invasion of more than 3.0 + mm and not more than 5.0 mm, with a horizontal spread of 7.0 mm or less. (from + AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer pT1a2 TNM Finding v8 + source: NCIt + cde_id: C139712 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139712" + term_id: C139712 + term_version: 20.05a + +t1b: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor limited to the + site of growth. The definition of T1b TNM finding depends on the specific type + of cancer that it refers to; for example, for breast cancer it refers to a primary + tumor that is more than 0.5 cm, but not more than 1.0 cm in greatest dimension; + for kidney cancer it refers to a primary tumor that is more than 4 cm, but not + more than 7 cm in greatest dimension; and for thyroid cancer it refers to a + primary tumor that is more than 1 cm but not more than 2 cm in greatest dimension. + termDef: + term: >- + T1b Stage Finding + source: NCIt + cde_id: C48722 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48722" + term_id: C48722 + term_version: 20.05a + +t1b1: + diagnosis: + ajcc_pathologic_t: + description: >- + Cervical cancer with clinically visible lesion 4.0 cm or less in greatest + dimension. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer pT1b1 TNM Finding v8 + source: NCIt + cde_id: C139714 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139714" + term_id: C139714 + term_version: 20.05a + ajcc_clinical_t: + description: >- + Cervical cancer with clinically visible lesion 4.0 cm or less in greatest + dimension. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer cT1b1 TNM Finding v8 + source: NCIt + cde_id: C139692 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139692" + term_id: C139692 + term_version: 20.05a + +t1b2: + diagnosis: + ajcc_clinical_t: + description: >- + Cervical cancer with clinically visible lesion more than 4.0 cm in greatest + dimension. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer cT1b2 TNM Finding v8 + source: NCIt + cde_id: C139693 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139693" + term_id: C139693 + term_version: 20.05a + ajcc_pathologic_t: + description: >- + Cervical cancer with clinically visible lesion more than 4.0 cm in greatest + dimension. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer pT1b2 TNM Finding v8 + source: NCIt + cde_id: C139715 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139715" + term_id: C139715 + term_version: 20.05a + +t1c: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor limited to the + site of growth. The definition of T1c TNM finding depends on the specific type + of cancer that it refers to; for example, for breast cancer it refers to a primary + tumor that is more than 1.0 cm, but not more than 2.0 cm in greatest dimension; + for uterine corpus cancer it refers to a primary tumor that invades one-half + or more of the myometrium; and for melanoma of the iris it refers to a primary + tumor limited to the iris with secondary glaucoma. + termDef: + term: >- + T1c Stage Finding + source: NCIt + cde_id: C48723 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48723" + term_id: C48723 + term_version: 20.05a + +t1mi: + common: + description: >- + A term that refers to a TNM finding of a primary tumor limited to the site of + growth and indicates microinvasion only. + termDef: + term: >- + T1mi Stage Finding + source: NCIt + cde_id: C95805 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95805" + term_id: C95805 + term_version: 20.05a + +t2: + common: + description: >- + A general term that refers to a TNM finding of primary tumor growth beyond the + level of in situ cancer, minimal subepithelial invasion, or minimal greatest + diameter. The definition of T2 TNM finding depends on the specific type of cancer + that it refers to; for example, for breast cancer it refers to primary tumor + that is more than 2.0 cm, but not more than 5.0 cm in greatest dimension; for + cutaneous melanoma it refers to primary tumor that is 1.01 to 2 mm in thickness, + with or without ulceration; for colorectal cancer it refers to primary tumor + with invasion into the muscularis propria; and for bladder cancer it refers + to primary tumor with invasion into the muscle layer. + termDef: + term: >- + T2 Stage Finding + source: NCIt + cde_id: C48724 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48724" + term_id: C48724 + term_version: 20.05a + diagnosis: + ensat_pathologic_t: + description: >- + Adrenal cancer with tumor size more than 5.0 cm. There is no invasion of tissues + outside the adrenal gland. (7th Ed, 2009) + termDef: + term: >- + pT2 ENSAT Staging Finding v7 + source: NCIt + cde_id: C104020 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104020" + term_id: C104020 + term_version: 23.03d + +t2a: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor growth beyond + the level of in situ cancer, minimal subepithelial invasion, or minimal greatest + diameter. The definition of T2a TNM finding depends on the specific type of + cancer that it refers to; for example, for kidney cancer it refers to a primary + tumor that measures more than 7 cm but less than or equal to 10 cm in greatest + dimension, and is limited to the kidney; for bladder cancer it refers to a primary + tumor that invades the superficial muscularis propria (inner half); for cervical + cancer it refers to a primary tumor that invades beyond the uterus but not to + the pelvic wall or to the lower third of vagina and there is no parametrial + invasion. + termDef: + term: >- + T2a Stage Finding + source: NCIt + cde_id: C48725 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48725" + term_id: C48725 + term_version: 20.05a + +t2a1: + diagnosis: + ajcc_clinical_t: + description: >- + Cervical carcinoma invading beyond the uterus but not to the pelvic wall or + to lower third of vagina without parametrial invasion. Clinically visible + lesion 4.0 cm or less in greatest dimension. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer cT2a1 TNM Finding v8 + source: NCIt + cde_id: C139696 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139696" + term_id: C139696 + term_version: 20.05a + ajcc_pathologic_t: + description: >- + Cervical carcinoma invading beyond the uterus but not to the pelvic wall or + to lower third of vagina without parametrial invasion. Clinically visible + lesion 4.0 cm or less in greatest dimension. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer pT2a1 TNM Finding v8 + source: NCIt + cde_id: C139718 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139718" + term_id: C139718 + term_version: 20.05a + +t2a2: + diagnosis: + ajcc_clinical_t: + description: >- + Cervical carcinoma invading beyond the uterus but not to the pelvic wall or + to lower third of vagina without parametrial invasion. Clinically visible + lesion more than 4.0 cm in greatest dimension. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer cT2a2 TNM Finding v8 + source: NCIt + cde_id: C139697 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139697" + term_id: C139697 + term_version: 20.05a + ajcc_pathologic_t: + description: >- + Cervical carcinoma invading beyond the uterus but not to the pelvic wall or + to lower third of vagina without parametrial invasion. Clinically visible + lesion more than 4.0 cm in greatest dimension. (from AJCC 8th Ed.) + termDef: + term: >- + Cervical Cancer pT2a2 TNM Finding v8 + source: NCIt + cde_id: C139719 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139719" + term_id: C139719 + term_version: 20.05a + +t2b: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor growth beyond + the level of in situ cancer, minimal subepithelial invasion, or minimal greatest + diameter. The definition of T2b TNM finding depends on the specific type of + cancer that it refers to; for example, for kidney cancer it refers to a primary + tumor that measures more than 10 cm in greatest dimension, and is limited to + the kidney; for bladder cancer it refers to a primary tumor that invades the + deep muscularis propria (outer half); for cervical cancer it refers to a primary + tumor that invades beyond the uterus but not to the pelvic wall or to the lower + third of vagina and there is parametrial invasion. + termDef: + term: >- + T2b Stage Finding + source: NCIt + cde_id: C48726 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48726" + term_id: C48726 + term_version: 20.05a + +t2c: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor growth beyond + the level of in situ cancer, minimal subepithelial invasion, or minimal greatest + diameter. The definition of T2c TNM finding depends on the specific type of + cancer that it refers to; for example, for prostate cancer it refers to a primary + tumor that involves both lobes of the prostate gland; for ovarian cancer it + refers to a primary tumor that involves one or both ovaries with extension or + implants on the uterus and/or fallopian tubes, or other pelvic tissues, with + malignant cells in either ascites or peritoneal washings; for fallopian tube + cancer it refers to a primary tumor with pelvic extension and malignant cells + in ascites or peritoneal washings. + termDef: + term: >- + T2c Stage Finding + source: NCIt + cde_id: C48727 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48727" + term_id: C48727 + term_version: 20.05a + +t2d: + common: + description: >- + A TNM stage finding term that refers to choroidal and ciliary body melanoma + or conjunctival melanoma TNM staging. For choroidal and ciliary body melanoma + it means tumor size category 2 with ciliary body involvement and extraocular + extension 5 mm or less in largest diameter. For conjunctival melanoma it means + caruncular tumor, and more than 1 quadrant of the nonbulbar conjunctiva involved. + (from AJCC 8th Ed.) + termDef: + term: >- + T2d Stage Finding + source: NCIt + cde_id: C148411 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148411" + term_id: C148411 + term_version: 20.05a + +t3: + common: + description: >- + A clinical and/or pathologic primary tumor TNM finding usually indicating that + the cancer is locally invasive, without infiltration of adjacent structures. + termDef: + term: >- + T3 Stage Finding + source: NCIt + cde_id: C48728 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48728" + term_id: C48728 + term_version: 20.05a + diagnosis: + ensat_pathologic_t: + description: >- + Adrenal cancer with tumor of any size. There is invasion of the fat that surrounds + the adrenal gland. (7th Ed, 2009) + termDef: + term: >- + pT3 ENSAT Staging Finding v7 + source: NCIt + cde_id: C104021 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104021" + term_id: C104021 + term_version: 23.03d + pathology_detail: + extrathyroid_extension: + description: >- + Thyroid cancer with a tumor size greater than 4 cm in greatest dimension and + limited to the thyroid gland, or a tumor of any size with minimal extrathyroid + extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). + (from AJCC 6th and 7th Eds.) + termDef: + term: >- + Thyroid Cancer pT3 TNM Finding v6 and v7 + source: NCIt + cde_id: C60864 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C60864" + term_id: C60864 + term_version: 23.08d + +t3a: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor usually indicating + that the cancer is locally invasive. The definition of T3a TNM finding depends + on the specific type of cancer that it refers to; for example, for kidney cancer + it refers to a primary tumor that grossly extends into the renal vein or its + segmental (muscle containing) branches or the tumor invades perirenal and/or + renal sinus fat but does not extends beyond Gerota's fascia; for cervical cancer + it refers to a primary tumor that involves the lower third of vagina, without + extension to pelvic wall; for liver cancer it refers to the presence of multiple + tumors measuring more than 5 cm in greatest dimension. + termDef: + term: >- + T3a Stage Finding + source: NCIt + cde_id: C48729 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48729" + term_id: C48729 + term_version: 20.05a + +t3b: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor usually indicating + that the cancer is locally invasive. The definition of T3b TNM finding depends + on the specific type of cancer that it refers to; for example, for kidney cancer + it refers to a primary tumor that grossly extends into the vena cava below the + diaphragm; for cervical cancer it refers to a primary tumor that extends to + the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney; for liver + cancer it refers to a single tumor or multiple tumors of any size involving + a major branch of the portal vein or hepatic vein. + termDef: + term: >- + T3b Stage Finding + source: NCIt + cde_id: C48730 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48730" + term_id: C48730 + term_version: 20.05a + +t3c: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor usually indicating + that the cancer is locally invasive. The definition of T3c TNM finding depends + on the specific type of cancer that it refers to; for example, for kidney cancer + it refers to a primary tumor that grossly extends into the vena cava above the + diaphragm, or invades the wall of the vena cava; for fallopian tube cancer it + refers to a primary tumor with peritoneal metastasis outside the pelvis measuring + more than 2 cm in diameter; for melanoma of the conjunctiva it refers to a primary + tumor invading the orbit. + termDef: + term: >- + T3c Stage Finding + source: NCIt + cde_id: C48731 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48731" + term_id: C48731 + term_version: 20.05a + +t3d: + common: + description: >- + A TNM stage finding term that refers to choroidal and ciliary body melanoma, + conjunctival melanoma, or retinoblastoma TNM staging. For choroidal and ciliary + body melanoma it means tumor size category 3 with ciliary body involvement and + extraocular extension 5 mm or less in largest diameter. For conjunctival melanoma + it means tumor of any size invading the nasolacrimal duct and/or lacrimal sac + and/or paranasal sinuses. For retinoblastoma it means hyphema and/or massive + vitreous hemorrhage (clinical) or full-thickness invasion into the outer third + of the sclera and/or invasion into or around emissary channels (pathologic). + (from AJCC 8th Ed.) + termDef: + term: >- + T3d Stage Finding + source: NCIt + cde_id: C148412 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148412" + term_id: C148412 + term_version: 20.05a + +t4: + common: + description: >- + A clinical and/or pathologic primary tumor TNM finding indicating direct invasion + of adjacent structures by cancer. + termDef: + term: >- + T4 Stage Finding + source: NCIt + cde_id: C48732 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48732" + term_id: C48732 + term_version: 20.05a + diagnosis: + ensat_pathologic_t: + description: >- + Adrenal cancer with tumor of any size. There is invasion of nearby organs + such as the kidney, pancreas, spleen or liver. (7th Ed, 2009) + termDef: + term: >- + pT4 ENSAT Staging Finding v7 + source: NCIt + cde_id: C104022 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104022" + term_id: C104022 + term_version: 23.03d + +t4a: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor with direct invasion + of adjacent structures. The definition of T4a TNM finding depends on the specific + type of cancer that it refers to; for example, for bladder cancer it refers + to a primary tumor that invades the prostatic stroma, uterus, and vagina; for + gastric cancer it refers to a primary tumor that invades the serosa (visceral + peritoneum); for colorectal cancer it refers to a primary tumor that penetrates + to the surface of the visceral peritoneum. + termDef: + term: >- + T4a Stage Finding + source: NCIt + cde_id: C48733 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48733" + term_id: C48733 + term_version: 20.05a + pathology_detail: + extrathyroid_extension: + description: >- + Thyroid cancer with moderately advanced local disease. Tumor of any size extending + beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, + trachea, esophagus, or recurrent laryngeal nerve. (from AJCC 7th Ed.) + termDef: + term: >- + Thyroid Cancer pT4a TNM Finding v7 + source: NCIt + cde_id: C89150 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C89150" + term_id: C89150 + term_version: 23.08d + +t4b: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor with direct invasion + of adjacent structures. The definition of T4b TNM finding depends on the specific + type of cancer that it refers to; for example, for bladder cancer it refers + to a primary tumor that invades the pelvic wall and abdominal wall; for gastric + cancer it refers to a primary tumor that invades adjacent structures; for colorectal + cancer it refers to a primary tumor with direct invasion or adherence to other + organs or structures. + termDef: + term: >- + T4b Stage Finding + source: NCIt + cde_id: C48734 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48734" + term_id: C48734 + term_version: 20.05a + pathology_detail: + extrathyroid_extension: + description: >- + Thyroid cancer with very advanced disease. Tumor invades prevertebral fascia + or encases carotid artery or mediastinal vessels. (from AJCC 7th Ed.) + termDef: + term: >- + Thyroid Cancer pT4b TNM Finding v7 + source: NCIt + cde_id: C89152 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C89152" + term_id: C89152 + term_version: 23.08d + +t4c: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor with direct invasion + of adjacent structures. The definition of T4c TNM finding depends on the specific + type of cancer that it refers to; for example, for breast cancer it refers to + a primary tumor that extends to the chest wall, not including the pectoralis + muscle, and with edema (including peau d'orange) or ulceration of the skin of + the breast or satellite skin nodules confined to the same breast; for ocular + adnexal lymphoma it refers to a primary tumor that Involves the maxillofacial, + ethmoidal, and/or frontal sinuses; for carcinoma of the conjunctiva it refers + to a primary tumor that invades adjacent paranasal sinuses. + termDef: + term: >- + T4c Stage Finding + source: NCIt + cde_id: C48735 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48735" + term_id: C48735 + term_version: 20.05a + +t4d: + common: + description: >- + A general term that refers to a TNM finding of a primary tumor with direct invasion + of adjacent structures. The definition of T4d TNM finding depends on the specific + type of cancer that it refers to; for example, for breast cancer it refers to + a primary tumor that meets the clinical-pathologic criteria of inflammatory + carcinoma; for ocular adnexal lymphoma it refers to a primary tumor with intracranial + spread; for carcinoma of the conjunctiva it refers to a primary tumor that invades + the brain. + termDef: + term: >- + T4d Stage Finding + source: NCIt + cde_id: C48736 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48736" + term_id: C48736 + term_version: 20.05a + +t4e: + common: + description: >- + Choroidal and ciliary body melanoma, any tumor size category with extraocular + extension more than 5 mm in largest diameter. (from AJCC 8th Ed.) + termDef: + term: >- + Choroidal and Ciliary Body Melanoma pT4e TNM Finding v8 + source: NCIt + cde_id: C140651 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140651" + term_id: C140651 + term_version: 20.05a + +ta: + common: + description: >- + A term that refers to a TNM finding of a primary, non-invasive, papillary cancer. + termDef: + term: >- + Ta Stage Finding + source: NCIt + cde_id: C96025 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C96025" + term_id: C96025 + term_version: 20.05a + +taf15: + common: + description: >- + This gene plays a role in transcriptional initiation. + termDef: + term: >- + TAF15 Gene + source: NCIt + cde_id: C95994 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95994" + term_id: C95994 + term_version: 20.10d + +tafasitamab: + common: + description: >- + An Fc engineered, humanized anti-CD19 monoclonal antibody directed against the + B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic + activities.Tafasitamab targets and binds to CD19, thereby depleting and eliminating + CD19-expressing B-cells. The modified Fc region of XmAb5574 increases binding + affinity to Fc-gamma receptors of effector cells and thereby enhances antibody-dependent + cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis + (ADCP). CD19 is widely expressed during B-cell development, from pro-B-cell + to early plasma cell stages. + termDef: + term: >- + Tafasitamab + source: NCIt + cde_id: C95768 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95768" + term_id: C95768 + term_version: 20.10d + +tail_of_pancreas: + common: + description: >- + The left extremity of the pancreas within the lienorenal ligament. + termDef: + term: >- + Tail of the Pancreas + source: NCIt + cde_id: C12271 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12271" + term_id: C12271 + term_version: 20.05a + +taiwan: + common: + description: >- + A group of islands bordering the East China Sea, Philippine Sea, South China + Sea, and Taiwan Strait, off the southeastern coast of China north of the Philippines. + termDef: + term: >- + Taiwan + source: NCIt + cde_id: C17184 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17184" + term_id: C17184 + term_version: 19.12e + +tajikistan: + common: + description: >- + A country in central Asia, south of Kyrgyzstan and west of China. + termDef: + term: >- + Tajikistan + source: NCIt + cde_id: C17183 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17183" + term_id: C17183 + term_version: 19.12e + +tal1: + common: + description: >- + This gene plays a role in regulation of transcription and cell organization. + It is involved in both embryonic hematopoiesis and adult erythropoiesis. + termDef: + term: >- + TAL1 Gene + source: NCIt + cde_id: C18301 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18301" + term_id: C18301 + term_version: 20.10d + +tal2: + common: + description: >- + This gene is involved in transcriptional regulation. It plays a role in T-cell + acute lymphocytic leukemia. + termDef: + term: >- + TAL2 Gene + source: NCIt + cde_id: C24843 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24843" + term_id: C24843 + term_version: 20.10d + +taletrectinib: + common: + description: >- + An orally available inhibitor of the receptor tyrosine kinases C-ros oncogene + 1 (ROS1) and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and + 3, with potential antineoplastic activity. Upon oral administration, taletrectinib + binds to and inhibits ROS1 and the NTRK family members. This inhibition leads + to a disruption of ROS1- and NTRK-mediated signaling and eventually inhibits + the growth of tumor cells that are overexpressing ROS1 and/or NTRKs. ROS1, overexpressed + in certain cancer cells, plays a key role in cell growth and survival of cancer + cells. NTRK mutations or rearrangements play a key role in cancer progression. + termDef: + term: >- + Taletrectinib + source: NCIt + cde_id: C118948 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C118948" + term_id: C118948 + term_version: 20.10d + +tamrintamab_pamozirine: + common: + description: >- + An antibody-drug conjugate (ADC) composed of a proprietary monoclonal antibody + against a tumor-associated antigen (TAA) linked to an as of yet undisclosed + cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration + of tamrintamab pamozirine, the monoclonal antibody moiety of SC-003 targets + and binds to the TAA expressed on tumor cells. Upon binding and internalization, + the cytotoxic agent is released and kills the TAA-expressing cancer cells, through + an as of yet unknown mechanism of action. + termDef: + term: >- + Tamrintamab Pamozirine + source: NCIt + cde_id: C124133 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124133" + term_id: C124133 + term_version: 20.10d + +tankyrase_inhibitor_stp1002: + common: + description: >- + An orally bioavailable inhibitor of the poly (ADP-ribose) polymerase (PARP) + enzyme tankyrase, with potential antineoplastic activity. Upon administration, + tankyrase inhibitor STP1002 selectively binds to and inhibits the activity of + tankyrase. This may block the tankyrase-mediated poly(ADP-ribosyl)ation of multiple + target proteins including various tumor suppressors. This may include the blockage + of the poly(ADP-ribosyl)ation and destabilization of AXIN, a negative regulator + of beta-catenin, and prevents Wnt/beta-catenin signaling. This may inhibit the + activation of transcription of a wide range of target genes of Wnt/beta-catenin + signaling, thereby preventing gene expression of many Wnt-related, pro-survival + proteins and suppressing tumor cell growth. Tankyrase, a member of the PARP + family, plays an important role in the regulation of the Wnt/beta-catenin signaling + pathway, tumor suppressors, as well as telomere maintenance and mitosis regulation. + termDef: + term: >- + Tankyrase Inhibitor STP1002 + source: NCIt + cde_id: C174060 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C174060" + term_id: C174060 + term_version: 20.10d + +tanycytic_ependymoma: + common: + description: >- + A variant of ependymoma, often found in the spinal cord, with tumor cells arranged + in fascicles of variable width and cell density. Ependymal rosettes are generally + absent, so this lesion must be distinguished from astrocytic neoplasms, but + its EM characteristics are ependymal. (Adapted from WHO.) + termDef: + term: >- + Tanycytic Ependymoma + source: NCIt + cde_id: C6903 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6903" + term_id: C6903 + term_version: 20.05a + +tanzania: + common: + description: >- + A country in eastern Africa, bordering the Indian Ocean, between Kenya and Mozambique. + termDef: + term: >- + Tanzania + source: NCIt + cde_id: C17185 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17185" + term_id: C17185 + term_version: 19.12e + +tapotoclax: + common: + description: >- + An inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 + (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. + Upon administration, tapotoclax binds to and inhibits the activity of MCL-1. + This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes + and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging + to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes + tumor cell survival. + termDef: + term: >- + Tapotoclax + source: NCIt + cde_id: C127817 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127817" + term_id: C127817 + term_version: 20.10d + +targeted_sequencing: + common: + description: >- + A technique that determines the nucleotide sequence of a pre-specified region + of DNA or RNA by using primers that are specific for that region. + termDef: + term: >- + Next Generation Targeted Sequencing + source: NCIt + cde_id: C130177 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C130177" + term_id: C130177 + term_version: 20.10d + +tasadenoturev: + common: + description: >- + An adenovirus serotype 5 strain, selectively replication competent in cells + defective in the Rb/p16 tumor suppressor pathway, with potential oncolytic activity. + Tasadenoturev contains an integrin binding RGD-4C motif, allowing Coxsackie + adenovirus receptor-independent infection of tumor cells, which are often deficient + for Coxsackie and adenovirus receptors (CARs). Selectively replication competent + in cells that are defective in retinoblastoma gene (Rb) or cyclin-dependent + kinase inhibitor-2A (p16), active replication of oncolytic adenovirus Ad5-Delta + 24RGD in tumor cells may induce oncolysis or cell lysis. As integral components + of the late G1 restriction point, the Rb gene product and p16 are negative regulators + of the cell cycle; ovarian cancer cells and non-small cell lung cancer cells + may be defective in the Rb/p16 pathway. + termDef: + term: >- + Tasadenoturev + source: NCIt + cde_id: C74067 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74067" + term_id: C74067 + term_version: 20.10d + +tbl1xr1: + common: + description: >- + This gene is involved in transcriptional activation. + termDef: + term: >- + TBL1XR1 Gene + source: NCIt + cde_id: C80116 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80116" + term_id: C80116 + term_version: 20.10d + +tbx3: + common: + description: >- + This gene is involved in both transcriptional repression and limb development. + termDef: + term: >- + TBX3 Gene + source: NCIt + cde_id: C101638 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101638" + term_id: C101638 + term_version: 20.10d + +tcea1: + common: + description: >- + This gene is involved in transcription. + termDef: + term: >- + TCEA1 Gene + source: NCIt + cde_id: C97822 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97822" + term_id: C97822 + term_version: 20.10d + +tcell_large_granular_lymphocytic_leukemia: + common: + description: >- + A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase + in the number of peripheral blood large granular lymphocytes, without a clearly + identified cause. (WHO, 2001) + termDef: + term: >- + T-Cell Large Granular Lymphocyte Leukemia + source: NCIt + cde_id: C4664 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4664" + term_id: C4664 + term_version: 20.05a + +tcell_large_granular_lymphocytosis: + common: + description: >- + A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase + in the number of peripheral blood large granular lymphocytes, without a clearly + identified cause. (WHO, 2001) + termDef: + term: >- + T-Cell Large Granular Lymphocyte Leukemia + source: NCIt + cde_id: C4664 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4664" + term_id: C4664 + term_version: 20.05a + +tcell_lymphoma_nos: + common: + description: >- + A non-Hodgkin lymphoma of T-cell lineage. It includes the T lymphoblastic lymphoma + and the mature T- and NK-cell lymphomas. -- 2003 + termDef: + term: >- + T-Cell Non-Hodgkin Lymphoma + source: NCIt + cde_id: C3466 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3466" + term_id: C3466 + term_version: 20.05a + +tcell_rich_large_bcell_lymphoma: + common: + description: >- + A large B-cell lymphoma characterized by the presence of a limited number of + scattered neoplastic large B-lymphocytes which are admixed with numerous non-neoplastic + T-lymphocytes and frequently histiocytes. + termDef: + term: >- + T-Cell/Histiocyte-Rich Large B-Cell Lymphoma + source: NCIt + cde_id: C9496 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9496" + term_id: C9496 + term_version: 20.05a + +tcell_richhistiocyterich_large_bcell_lymphoma: + common: + description: >- + A large B-cell lymphoma characterized by the presence of a limited number of + scattered neoplastic large B-lymphocytes which are admixed with numerous non-neoplastic + T-lymphocytes and frequently histiocytes. + termDef: + term: >- + T-Cell/Histiocyte-Rich Large B-Cell Lymphoma + source: NCIt + cde_id: C9496 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9496" + term_id: C9496 + term_version: 20.05a + +tcf12: + common: + description: >- + This gene is involved in both transcriptional regulation and tissue differentiation. + termDef: + term: >- + TCF12 Gene + source: NCIt + cde_id: C97828 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97828" + term_id: C97828 + term_version: 20.10d + +tcf3: + common: + description: >- + This gene plays a role in regulation of transcription. It is involved in the + control of tissue-specific cell fate during embryogenesis. + termDef: + term: >- + TCF3 Gene + source: NCIt + cde_id: C24846 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24846" + term_id: C24846 + term_version: 20.10d + +tcf7l2: + common: + description: >- + This gene plays a role in signal transduction and regulation of transcription. + termDef: + term: >- + TCF7L2 Gene + source: NCIt + cde_id: C24847 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24847" + term_id: C24847 + term_version: 20.10d + +tcl1a: + common: + description: >- + This gene is involved in signal transduction. + termDef: + term: >- + TCL1A Gene + source: NCIt + cde_id: C92699 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C92699" + term_id: C92699 + term_version: 20.10d + +tebentafusp: + common: + description: >- + A fusion protein containing a modified form of human T-cell receptor (TCR) specific + for the gp100 antigen and fused to an anti-CD3 single-chain antibody fragment, + with potential antineoplastic activity. Upon direct intratumoral administration + of tebentafusp into the melanoma lesion, the TCR moiety of this agent targets + and binds to the tumor associated antigen (TAA) gp100 presented on the melanoma + tumor cell; the anti-CD3 fragment moiety binds to CD3- expressing T lymphocytes, + thereby selectively cross-linking tumor cells and T-lymphocytes. This may lead + to the recruitment of cytotoxic T lymphocytes (CTL) to the T lymphocyte/tumor + cell aggregates and result in CTL-mediated death of gp100-expressing melanoma + cancer cells. + termDef: + term: >- + Tebentafusp + source: NCIt + cde_id: C94208 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94208" + term_id: C94208 + term_version: 20.10d + +tec: + common: + description: >- + This gene is involved in signal transduction and regulation of immune function. + termDef: + term: >- + TEC Gene + source: NCIt + cde_id: C24850 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24850" + term_id: C24850 + term_version: 20.10d + +teclistamab: + common: + description: >- + A bispecific humanized monoclonal antibody against human CD3, a T-cell surface + antigen, and human B-cell maturation antigen (BCMA; TNFRSF17), a tumor-associated + antigen (TAA) expressed on plasma cells, with potential antineoplastic activity. + Upon administration, teclistamab binds to both CD3 on T-cells and BCMA expressed + on malignant plasma cells. This results in the cross-linking of T-cells and + tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against + BCMA-expressing plasma cells. BCMA, a member of the tumor necrosis factor receptor + superfamily that is specifically overexpressed on malignant plasma cells, plays + a key role in promoting plasma cell survival. + termDef: + term: >- + Teclistamab + source: NCIt + cde_id: C136823 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C136823" + term_id: C136823 + term_version: 20.10d + +tefinostat: + common: + description: >- + A hydroxamic acid-derived histone deacetylase (HDAC) inhibitor with potential + antineoplastic activity. Tefinostat inhibits HDAC leading to an accumulation + of highly acetylated histones, which may result in chromatin remodeling, inhibition + of tumor oncogene transcription, inhibition of tumor cell division, and the + induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor + types, deacetylates chromatin histone proteins; this agent may specifically + target HDACs in cells of the monocyte-macrophage lineage. + termDef: + term: >- + Tefinostat + source: NCIt + cde_id: C152539 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C152539" + term_id: C152539 + term_version: 20.10d + +telaglenastat: + common: + description: >- + An orally bioavailable inhibitor of glutaminase, with potential antineoplastic + activity. Upon oral administration, CB-839 selectively and irreversibly inhibits + glutaminase, a mitochondrial enzyme that is essential for the conversion of + the amino acid glutamine into glutamate. By blocking glutamine utilization, + proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors + rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites + to both provide energy and generate building blocks for the production of macromolecules, + which are needed for cellular growth and survival. + termDef: + term: >- + Telaglenastat + source: NCIt + cde_id: C114381 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C114381" + term_id: C114381 + term_version: 20.10d + +telaglenastat_hydrochloride: + common: + description: >- + The hydrochloride salt form of CB-839, an orally bioavailable inhibitor of glutaminase, + with potential antineoplastic and immunostimulating activities. Upon oral administration, + CB-839 selectively and reversibly binds to and inhibits human glutaminase, an + enzyme that is essential for the conversion of the amino acid glutamine into + glutamate. Blocking glutamine metabolism inhibits proliferation in rapidly growing + tumor cells and leads to an induction of cell death. Unlike normal healthy cells, + glutamine-dependent tumors heavily rely on the intracellular conversion of exogenous + glutamine into glutamate and glutamate metabolites to both provide energy and + generate building blocks for the production of macromolecules, which are needed + for cellular growth and survival. In addition, CB-839 causes accumulation of + glutamine in tumor cells and increases glutamine concentration in the tumor + microenvironment (TME) upon cell death. As glutamine is essential for T-cell + generation, CB-839 may also enhance T-cell proliferation and activation in the + TME, which may lead to further killing of tumor cells. + termDef: + term: >- + Telaglenastat Hydrochloride + source: NCIt + cde_id: C150413 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150413" + term_id: C150413 + term_version: 20.10d + +telangiectatic_osteosarcoma: + common: + description: >- + An osteosarcoma usually arising from the metaphysis of long bones. It is characterized + by the presence of a cystic architecture with blood-filled spaces. The prognosis + is similar to that of conventional osteosarcoma. + termDef: + term: >- + Telangiectatic Osteosarcoma + source: NCIt + cde_id: C3902 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3902" + term_id: C3902 + term_version: 20.05a + +telisotuzumab: + common: + description: >- + A monoclonal antibody directed against human hepatocyte growth factor receptor + (HGFR or c-Met), with potential antineoplastic activity. Telisotuzumab binds + to c-Met, thereby preventing both c-Met binding to its ligand, HGF and the subsequent + activation of the HGF/c-Met signaling pathway. This may cause cell death in + c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed + or mutated in many tumor cell types, plays a key role in cancer cell growth, + survival, angiogenesis, invasion, and metastasis. + termDef: + term: >- + Telisotuzumab + source: NCIt + cde_id: C106262 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106262" + term_id: C106262 + term_version: 20.10d + +temporal_lobe: + common: + description: >- + One of the cerebral lobes. It is located inferior to the frontal and parietal + lobes and anterior to the occipital lobe. + termDef: + term: >- + Temporal Lobe + source: NCIt + cde_id: C12353 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12353" + term_id: C12353 + term_version: 20.05a + +tenosynovial_giant_cell_tumor: + common: + description: >- + A tumor usually arising in the synovium of joints, bursa or tendon sheath. It + is characterized by the presence of mononuclear cells, multinucleated osteoclast-like + giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory + infiltrate. According to the growth pattern, it is classified as localized or + diffuse. + termDef: + term: >- + Tenosynovial Giant Cell Tumor + source: NCIt + cde_id: C3402 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3402" + term_id: C3402 + term_version: 20.05a + +tepoditamab: + common: + description: >- + An immunoglobulin G1 (IgG1) bispecific human monoclonal antibody against human + CD3, a T-cell surface antigen, and human C-type lectin domain family 12 member + A (CLEC12A), a tumor-associated antigen (TAA) overexpressed on certain tumor + cells, with potential antineoplastic activity. Upon administration, tepoditamab + binds to both CD3 on T-cells and CLEC12A expressed on malignant cells, such + as myeloid blasts, atypical progenitor cells and leukemic stem cells (LSCs). + This results in the cross-linking of T-cells with tumor cells, and induces a + potent cytotoxic T-lymphocyte (CTL) response against CLEC12A-expressing tumor + cells. CLEC12A, a myeloid differentiation antigen and member of the C-type lectin/C-type + lectin-like domain (CTL/CTLD) superfamily, is overexpressed on myeloid leukemia + cells, but not on normal early hematopoietic progenitors, including hematopoietic + stem cells (HSCs). + termDef: + term: >- + Tepoditamab + source: NCIt + cde_id: C148141 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148141" + term_id: C148141 + term_version: 20.10d + +teratoblastoma_malignant: + common: + description: >- + A teratoma characterized by the presence of an extensive component of immature, + fetal-type tissues. + termDef: + term: >- + Immature Teratoma + source: NCIt + cde_id: C4286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4286" + term_id: C4286 + term_version: 20.05a + +teratocarcinoma: + common: + description: >- + A germ cell tumor characterized by the presence of an embryonal carcinoma component + and a teratoma component. + termDef: + term: >- + Mixed Embryonal Carcinoma and Teratoma + source: NCIt + cde_id: C3756 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3756" + term_id: C3756 + term_version: 20.05a + +teratoma_benign: + common: + description: >- + A teratoma which may be cystic; it is composed entirely of well differentiated, + adult-type mature tissues, without evidence of fetal-type immature tissues (grade + 0 teratoma). + termDef: + term: >- + Mature Teratoma + source: NCIt + cde_id: C9015 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9015" + term_id: C9015 + term_version: 20.05a + +teratoma_differentiated: + common: + description: >- + A teratoma which may be cystic; it is composed entirely of well differentiated, + adult-type mature tissues, without evidence of fetal-type immature tissues (grade + 0 teratoma). + termDef: + term: >- + Mature Teratoma + source: NCIt + cde_id: C9015 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9015" + term_id: C9015 + term_version: 20.05a + +teratoma_malignant_nos: + common: + description: >- + A teratoma characterized by the presence of an extensive component of immature, + fetal-type tissues. + termDef: + term: >- + Immature Teratoma + source: NCIt + cde_id: C4286 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4286" + term_id: C4286 + term_version: 20.05a + +teratoma_nos: + common: + description: >- + A non-seminomatous germ cell tumor characterized by the presence of various + tissues which correspond to the different germinal layers (endoderm, mesoderm, + and ectoderm). It occurs in the testis, ovary, and extragonadal sites including + central nervous system, mediastinum, lung, and stomach. According to the level + of differentiation of the tissues which comprise the tumor, teratomas are classified + as benign (grade 0 or 1), immature (grade 2), and malignant (grade 3). Grade + 0 teratomas contain only mature elements; grade 1 teratomas have a limited degree + of immaturity; grade 2 teratomas have a more extensive degree of immaturity; + grade 3 teratomas are composed exclusively of immature tissues. The prognosis + depends on patient age, tumor size and grade, and stage. + termDef: + term: >- + Teratoma + source: NCIt + cde_id: C3403 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3403" + term_id: C3403 + term_version: 20.05a + +teratoma_with_malignant_transformation: + common: + description: >- + A teratoma which is characterized by morphologic transformation to malignancy + and an aggressive clinical course. The malignant component most often is sarcomatous + or carcinomatous. + termDef: + term: >- + Teratoma with Somatic-Type Malignancy + source: NCIt + cde_id: C4289 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4289" + term_id: C4289 + term_version: 20.05a + +tert: + common: + description: >- + This gene is involved in cell cycle regulation and telomere maintenance. + termDef: + term: >- + TERT Gene + source: NCIt + cde_id: C18173 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18173" + term_id: C18173 + term_version: 20.10d + +test_value_reported: + common: + description: >- + An indication as to whether a test value has been reported or recorded. + termDef: + term: >- + Test Value Reported Indicator + source: NCIt + cde_id: C165229 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165229" + term_id: C165229 + term_version: 20.10d + +testicular_adenoma: + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +testicular_cancer: + common: + description: >- + A malignant tumor predominantly affecting young men and often associated with + cryptorchidism. Seminoma is the most frequently seen malignant testicular germ + cell tumor, followed by embryonal carcinoma and yolk sac tumor. + termDef: + term: >- + Malignant Testicular Germ Cell Tumor + source: NCIt + cde_id: C9063 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9063" + term_id: C9063 + term_version: 19.12e + +testis_nos: + common: + description: >- + Either of the paired male reproductive glands that produce the male germ cells + and the male hormones. + termDef: + term: >- + Testis + source: NCIt + cde_id: C12412 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12412" + term_id: C12412 + term_version: 20.05a + +testosterone: + common: + description: >- + The determination of the amount of free and bound testosterone present in a + sample. + termDef: + term: >- + Total Testosterone Measurement + source: NCIt + cde_id: C74793 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74793" + term_id: C74793 + term_version: 20.10d + +tet1: + common: + description: >- + This gene is involved in the regulation of DNA methylation. + termDef: + term: >- + TET1 Gene + source: NCIt + cde_id: C95423 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95423" + term_id: C95423 + term_version: 20.10d + +tet2: + common: + description: >- + This gene is involved in oxidation. + termDef: + term: >- + TET2 Gene + source: NCIt + cde_id: C95252 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95252" + term_id: C95252 + term_version: 20.10d + +tetoo_early: + common: + description: >- + At a point before the usual, expected, or specified time. + termDef: + term: >- + Too Early + source: NCIt + cde_id: C133441 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C133441" + term_id: C133441 + term_version: 20.05a + +tetraploid: + common: + description: >- + A numerical chromosomal abnormality characterized by the presence of four complete + sets of chromosomes. + termDef: + term: >- + Tetraploidy + source: NCIt + cde_id: C28450 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28450" + term_id: C28450 + term_version: 20.10d + +tf_binding_site_variant: + common: + description: >- + A change in the nucleotide sequence of a transcription factor binding site for + a gene. + termDef: + term: >- + Transcription Factor Binding Site Mutation + source: NCIt + cde_id: C148652 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148652" + term_id: C148652 + term_version: 20.10d + +tfbs_ablation: + common: + description: >- + A deletion mutation where the deleted sequence includes a transcription factor + binding site for a gene. + termDef: + term: >- + Transcription Factor Binding Site Deletion Mutation + source: NCIt + cde_id: C148653 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148653" + term_id: C148653 + term_version: 20.10d + +tfbs_amplification: + common: + description: >- + An increase in the copy number of a region containing a transcription factor + binding site for a gene. + termDef: + term: >- + Transcription Factor Binding Site Amplification + source: NCIt + cde_id: C148654 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148654" + term_id: C148654 + term_version: 20.10d + +tfe3: + common: + description: >- + This gene plays a role in transcriptional activation. It is involved in melanogenesis. + termDef: + term: >- + TFE3 Gene + source: NCIt + cde_id: C24854 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24854" + term_id: C24854 + term_version: 20.10d + +tfeb: + common: + description: >- + This gene plays a role in transcription. + termDef: + term: >- + TFEB Gene + source: NCIt + cde_id: C94761 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94761" + term_id: C94761 + term_version: 20.10d + +tfg: + common: + description: >- + This gene is involved in signaling. + termDef: + term: >- + TFG Gene + source: NCIt + cde_id: C97834 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97834" + term_id: C97834 + term_version: 20.10d + +tfpt: + common: + description: >- + This gene plays a role in the regulation of apoptosis. + termDef: + term: >- + TFPT Gene + source: NCIt + cde_id: C97837 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97837" + term_id: C97837 + term_version: 20.10d + +tfrc: + common: + description: >- + This gene plays a regulatory role in receptor-mediated endocytosis and iron + metabolism. + termDef: + term: >- + TFRC Gene + source: NCIt + cde_id: C38517 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38517" + term_id: C38517 + term_version: 20.10d + +tgamma_lymphoproliferative_disease: + common: + description: >- + A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase + in the number of peripheral blood large granular lymphocytes, without a clearly + identified cause. (WHO, 2001) + termDef: + term: >- + T-Cell Large Granular Lymphocyte Leukemia + source: NCIt + cde_id: C4664 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4664" + term_id: C4664 + term_version: 20.05a + +tgfape38_immunotoxin: + common: + description: >- + A recombinant, chimeric toxin composed of human transforming growth factor alpha + (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding + domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing + the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated + apoptosis of tumor cells via a mechanism involving mitochondrial damage; it + also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide + (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation + factor 2 and inhibiting protein synthesis. (NCI04) + termDef: + term: >- + TGFa-PE38 Immunotoxin + source: NCIt + cde_id: C29483 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C29483" + term_id: C29483 + term_version: 20.10d + +tgfbeta_receptor_1_kinase_inhibitor_sh3051: + common: + description: >- + An orally bioavailable, small molecule inhibitor of the serine/threonine kinase + transforming growth factor-beta (TGF-beta) receptor 1 (TGFbR1; activin receptor-like + kinase 5; ALK5), with potential antineoplastic and immunomodulating activities. + Upon administration, TGFbR1 inhibitor SH3051 specifically targets and binds + to TGFbR1, which prevents TGFbR1-mediated signal transduction. This abrogates + TGFbR1-mediated immunosuppression, enhances anti-tumor immunity in the tumor + microenvironment (TME) and promotes a cytotoxic T-lymphocyte (CTL)-mediated + immune response against tumor cells leading to tumor cell death. This may lead + to a reduction in TGFbR1-dependent proliferation of tumor cells. The TGF-beta + signaling pathway is often deregulated in tumors and plays a key role in the + regulation of cell growth, differentiation, apoptosis, motility, invasion, and + angiogenesis. It plays a key role in immunosuppression in the TME and cancer + cell progression. + termDef: + term: >- + TGF-beta Receptor 1 Kinase Inhibitor SH3051 + source: NCIt + cde_id: C173370 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173370" + term_id: C173370 + term_version: 20.10d + +tgfbeta_receptor_1_kinase_inhibitor_yl13027: + common: + description: >- + An orally bioavailable inhibitor of the serine/threonine kinase transforming + growth factor-beta receptor 1 (TGFbR1; activin receptor-like kinase 5; ALK5), + with potential antineoplastic and immunomodulating activities. Upon administration, + TGF-betaR1 inhibitor YL-13027 specifically targets and binds to TGFbR1, which + prevents TGFbR1-mediated signal transduction. This abrogates TGFbR1-mediated + immunosuppression, enhances anti-tumor immunity in the tumor microenvironment + (TME) and promotes a cytotoxic T-lymphocyte (CTL)-mediated immune response against + tumor cells leading to tumor cell death. This may lead to a reduction in TGFbR1-dependent + proliferation of cancer cells. The TGFb signaling pathway is often deregulated + in tumors and plays a key role in the regulation of cell growth, differentiation, + apoptosis, motility, invasion, and angiogenesis. It plays a key role in immunosuppression + in the TME and cancer cell progression. + termDef: + term: >- + TGF-beta Receptor 1 Kinase Inhibitor YL-13027 + source: NCIt + cde_id: C172107 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172107" + term_id: C172107 + term_version: 20.10d + +tgfbr2: + common: + description: >- + This gene plays a role in cellular proliferation and mitogenic responses. + termDef: + term: >- + TGFBR2 Gene + source: NCIt + cde_id: C18592 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18592" + term_id: C18592 + term_version: 20.10d + +thailand: + common: + description: >- + A country in southeastern Asia, bordering the Andaman Sea and the Gulf of Thailand, + southeast of Burma. + termDef: + term: >- + Thailand + source: NCIt + cde_id: C17192 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17192" + term_id: C17192 + term_version: 19.12e + +theca_cell_tumor: + common: + description: >- + An ovarian or testicular stromal tumor characterized by the presence of lipid-rich + neoplastic spindle cells. In females, uterine bleeding is the most common symptom. + A minority of post-menopausal women with thecoma have an associated endometrial + adenocarcinoma or rarely a malignant mixed mullerian tumor or endometrial stromal + sarcoma. Rare cases with nuclear atypia and mitotic activity may metastasize. + In males, thecomas are rare and they usually present as slow growing, sometimes + painful masses. Metastases have not been reported. + termDef: + term: >- + Thecoma + source: NCIt + cde_id: C3405 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3405" + term_id: C3405 + term_version: 20.05a + +theca_cellgranulosa_cell_tumor: + common: + description: >- + A general term used to describe sex cord-stromal tumors characterized by the + presence of granulosa cells in a thecomatous/fibrothecomatous background. + termDef: + term: >- + Granulosa Cell-Theca Cell Tumor + source: NCIt + cde_id: C66751 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66751" + term_id: C66751 + term_version: 20.05a + +thecoma_luteinized: + common: + description: >- + A variant of ovarian thecoma characterized by the presence of lutein cells. + It is associated with a lower frequency of estrogenic manifestations compared + to typical thecomas. In a minority of cases androgenic manifestations are present. + termDef: + term: >- + Ovarian Luteinized Thecoma + source: NCIt + cde_id: C4203 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4203" + term_id: C4203 + term_version: 20.05a + +thecoma_malignant: + common: + description: >- + A thecoma of the ovary which may metastasize to another anatomic site. It is + usually characterized by nuclear atypia and mitotic activity. Malignant thecomas + are rare. + termDef: + term: >- + Malignant Ovarian Thecoma + source: NCIt + cde_id: C6929 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6929" + term_id: C6929 + term_version: 20.05a + +thecoma_nos: + common: + description: >- + An ovarian or testicular stromal tumor characterized by the presence of lipid-rich + neoplastic spindle cells. In females, uterine bleeding is the most common symptom. + A minority of post-menopausal women with thecoma have an associated endometrial + adenocarcinoma or rarely a malignant mixed mullerian tumor or endometrial stromal + sarcoma. Rare cases with nuclear atypia and mitotic activity may metastasize. + In males, thecomas are rare and they usually present as slow growing, sometimes + painful masses. Metastases have not been reported. + termDef: + term: >- + Thecoma + source: NCIt + cde_id: C3405 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3405" + term_id: C3405 + term_version: 20.05a + +therapeutic_cancer_vaccine_atp128: + common: + description: >- + A self-adjuvanted chimeric recombinant protein vaccine, based on the self-adjuvanting + KISIMA immunization platform, composed of three components: the 42 residue fragment + Z12, a cell penetrating peptide (CPP) derived from the ZEBRA protein transduction + domain, a toll-like receptor (TLR) peptide agonist as an adjuvant and a chimeric + cargo, a multiple antigenic domain (MAD; MultiE), that contains an as of yet + not disclosed amount of major histocompatibility class (MHC)-restricted peptides + derived from as of yet undisclosed tumor-associated antigens (TAAs) that are + specific for colorectal cancer (CRC) patients, with potential immunomodulating + and antineoplastic activities. Upon administration of ATP128, the Z12 moiety + targets, binds to and penetrates antigen-presenting cells (APCs), specifically + dendritic cells (DCs) and promotes the loading of the epitopes into the DCs + and transports antigenic cargoes into both endosomal and cytosolic compartments. + Upon processing and antigen presentation by MHC II and I, the immune system + is stimulated and activates specific CD4+ and CD8+ T-cells, respectively, against + the multi-epitopes specific for the CRC cells, thereby killing the CRC cells. + termDef: + term: >- + Therapeutic Cancer Vaccine ATP128 + source: NCIt + cde_id: C165621 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165621" + term_id: C165621 + term_version: 20.10d + +therapy_related_myeloid_neoplasm: + common: + description: >- + Acute myeloid leukemias, myelodysplastic syndromes, and myelodysplastic/myeloproliferative + neoplasms arising as a result of the mutagenic effect of chemotherapy agents + and/or radiation that are used for the treatment of neoplastic or non-neoplastic + disorders. + termDef: + term: >- + Therapy-Related Myeloid Neoplasm + source: NCIt + cde_id: C27912 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27912" + term_id: C27912 + term_version: 20.05a + +therapyrelated_acute_myeloid_leukemia_alkylating_agent_related: + common: + description: >- + Acute myeloid leukemia occurring as late complication of prior therapy with + alkylating agents. + termDef: + term: >- + Alkylating Agent-Related Acute Myeloid Leukemia + source: NCIt + cde_id: C27754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27754" + term_id: C27754 + term_version: 20.05a + +therapyrelated_acute_myeloid_leukemia_epipodophyllotoxinrelated: + common: + description: >- + Acute myeloid leukemia occurring as late complication of prior therapy with + alkylating agents. + termDef: + term: >- + Alkylating Agent-Related Acute Myeloid Leukemia + source: NCIt + cde_id: C27754 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27754" + term_id: C27754 + term_version: 20.05a + +therapyrelated_acute_myeloid_leukemia_nos: + common: + description: >- + An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy + agents and/or ionizing radiation. (WHO, 2001) + termDef: + term: >- + Therapy-Related Acute Myeloid Leukemia + source: NCIt + cde_id: C8252 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8252" + term_id: C8252 + term_version: 20.05a + +therapyrelated_myelodysplastic_syndrome_alkylating_agent_related: + common: + description: >- + A disorder seen following cancer chemotherapy. It is the most common cause of + therapy-related myelodysplastic syndromes. It typically manifests several years + after initiation of single or multi-agent chemotherapy with alkylators. Mutagenic + potential of alkylating agents is believed to be age and cumulative dose-dependent. + Deletions in chromosomes 5 and 7 are associated with susceptibility to this + disorder. Clinical signs may include fatigue, dyspnea, bruising and frequent + infections. Clinical course may progress to bone marrow failure or acute myeloid + leukemia that is refractory to treatment. Prognosis is dismal with survivability + usually less than one year. + termDef: + term: >- + Alkylating Agent-Related Myelodysplastic Syndrome + source: NCIt + cde_id: C7643 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7643" + term_id: C7643 + term_version: 20.05a + +therapyrelated_myelodysplastic_syndrome_epipodophyllotoxinrelated: + common: + description: >- + A disorder seen following cancer chemotherapy. It typically manifests a few + years after initiation of epipodophyllotoxin chemotherapy. Mutagenic potential + of these non-intercalating DNA topoisomerase II inhibitors is believed to be + increased with concurrent use of asparaginase or granulocyte colony-stimulating + factor. Balanced translocations involving chromosomal bands 11q23 and 21q22 + are commonly associated with this disorder. Clinical signs may include fatigue, + dyspnea, bruising and frequent infections. Clinical course usually progresses + to acute myeloid leukemia though most epipodophyllotoxin-related leukemias do + not have an antecedent myelodysplastic phase. Prognosis is dismal with survivability + usually less than one year. + termDef: + term: >- + Epipodophyllotoxin-Related Myelodysplastic Syndrome + source: NCIt + cde_id: C7642 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7642" + term_id: C7642 + term_version: 20.05a + +therapyrelated_myelodysplastic_syndrome_nos: + common: + description: >- + A myelodysplastic syndrome caused by chemotherapy and/or radiotherapy. + termDef: + term: >- + Therapy-Related Myelodysplastic Syndrome + source: NCIt + cde_id: C27722 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27722" + term_id: C27722 + term_version: 20.05a + +thoracentesis: + common: + description: >- + The removal of excess fluid via needle puncture from the thoracic cavity. + termDef: + term: >- + Thoracentesis + source: NCIt + cde_id: C15392 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C15392" + term_id: C15392 + term_version: 20.05a + +thoracic_esophagus: + common: + description: >- + Clinical esophageal segment composed of smooth muscle. It includes the middle + third topographic segment, as well as parts of the upper and lower thirds. + termDef: + term: >- + Thoracic Esophagus + source: NCIt + cde_id: C12251 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12251" + term_id: C12251 + term_version: 20.05a + +thorax_nos: + common: + description: >- + The division of the body lying between the neck and the abdomen. + termDef: + term: >- + Thorax + source: NCIt + cde_id: C12799 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12799" + term_id: C12799 + term_version: 20.05a + +thorium_th_227_anetumab_corixetan: + common: + description: >- + A radioimmunoconjugate consisting of anetumab, a human immunoglobulin G1 (IgG1) + monoclonal antibody directed against the cell surface glycoprotein mesothelin, + conjugated to the chelating agent corixetan, and labeled with the alpha-emitting + radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration + of thorium Th 227 anetumab corixetan, the anetumab moiety binds to the tumor-associated + antigen (TAA) mesothelin, delivering a cytotoxic dose of alpha radiation to + cells expressing mesothelin. + termDef: + term: >- + Thorium Th 227 Anetumab Corixetan + source: NCIt + cde_id: C155977 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155977" + term_id: C155977 + term_version: 20.10d + +thorium_th_227_antiher2_monoclonal_antibody_bay2701439: + common: + description: >- + A radioimmunoconjugate consisting of a monoclonal antibody targeting the tyrosine + kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2) and labeled + with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic + activity. Upon administration, the monoclonal antibody moiety of BAY2701439 + targets and specifically binds to HER2 on tumor cells, delivering a cytotoxic + dose of alpha radiation to cells expressing HER2. HER2 is overexpressed in a + variety of cancer cell types and is associated with increased tumor cell proliferation. + termDef: + term: >- + Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439 + source: NCIt + cde_id: C168996 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168996" + term_id: C168996 + term_version: 20.10d + +thorium_th_227_antipsma_monoclonal_antibody_bay_2315497: + common: + description: >- + A radioimmunoconjugate consisting of a monoclonal antibody targeting the tumor-associated + antigen (TAA) human prostate-specific membrane antigen (PSMA) and labeled, via + a 3-hydroxypyridin-2-one (3,2-HOPO) chelator, with the alpha-emitting radioisotope + thorium Th 227, with potential antineoplastic activity. Upon administration, + the monoclonal antibody moiety of BAY 2315497 targets and specifically binds + to PSMA on tumor cells, delivering a cytotoxic dose of alpha radiation to cells + expressing PSMA. PSMA is overexpressed on the surface of metastatic and hormone-refractory + prostate cancer cells. + termDef: + term: >- + Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497 + source: NCIt + cde_id: C175301 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C175301" + term_id: C175301 + term_version: 20.10d + +thrap3: + common: + description: >- + This gene is involved in the activation of transcription. + termDef: + term: >- + THRAP3 Gene + source: NCIt + cde_id: C97840 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97840" + term_id: C97840 + term_version: 20.10d + +throat_cancer: + common: + description: >- + Carcinoma, predominantly squamous cell, arising from epithelial cells of the + larynx or pharynx. + termDef: + term: >- + Throat Carcinoma + source: NCIt + cde_id: C35506 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35506" + term_id: C35506 + term_version: 19.12e + +thymic_carcinoma_nos: + common: + description: >- + A diverse group of carcinomas of the thymus gland, previously known as thymoma + type C. It includes morphologic variants derived from purely epithelial cells, + as well as from cells with neuroendocrine differentiation. + termDef: + term: >- + Thymic Carcinoma + source: NCIt + cde_id: C7569 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7569" + term_id: C7569 + term_version: 20.05a + +thymic_large_bcell_lymphoma: + common: + description: >- + A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically + it is characterized by a massive diffuse lymphocytic proliferation associated + with compartmentalizing fibrosis. Response to intensive chemotherapy, with + or without radiotherapy, is usually good. (WHO, 2001) + termDef: + term: >- + Primary Mediastinal (Thymic) Large B-Cell Lymphoma + source: NCIt + cde_id: C9280 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9280" + term_id: C9280 + term_version: 20.05a + +thymidylate_synthase_inhibitor_cx1106: + common: + description: >- + A thymidylate synthase (TS) inhibitor with potential antineoplastic activity. + Upon administration, TS inhibitor CX1106 binds to and inhibits TS. This reduces + thymine nucleotide synthesis, inhibits DNA synthesis and cell division, causes + DNA damage and leads to tumor cell apoptosis. TS catalyzes the conversion of + deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), an + essential precursor for DNA synthesis, and plays a key role in cell growth and + division. + termDef: + term: >- + Thymidylate Synthase Inhibitor CX1106 + source: NCIt + cde_id: C168609 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C168609" + term_id: C168609 + term_version: 20.10d + +thymoma_atypical_malignant: + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +thymoma_atypical_nos: + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +thymoma_benign: + common: + description: >- + A thymoma that is completely surrounded by a capsule, without evidence of capsular + invasion, infiltration of the surrounding tissues, and metastases. + termDef: + term: >- + Benign Thymoma + source: NCIt + cde_id: C66746 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C66746" + term_id: C66746 + term_version: 20.05a + +thymoma_cortical_malignant: + common: + description: >- + A type B2 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B2 Thymoma + source: NCIt + cde_id: C6889 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6889" + term_id: C6889 + term_version: 20.05a + +thymoma_cortical_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of neoplastic large, + polygonal epithelial cells with large vesicular nuclei and prominent nucleoli. + The neoplastic cells are arranged around perivascular spaces and along septa. + Immature T-lymphocytes are also present. It may be associated with myasthenia + gravis, pure red cell aplasia, and hypogammaglobulinemia. It is a tumor of moderate + malignancy. The majority of cases occur in the anterior mediastinum as Masaoka + stage I, stage II, or stage III tumors. Metastatic, stage IV tumors occur less + frequently. + termDef: + term: >- + Thymoma Type B2 + source: NCIt + cde_id: C6888 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6888" + term_id: C6888 + term_version: 20.05a + +thymoma_epithelial_malignant: + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +thymoma_epithelial_nos: + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +thymoma_lymphocyterich_malignant: + common: + description: >- + A type B1 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B1 Thymoma + source: NCIt + cde_id: C7996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7996" + term_id: C7996 + term_version: 20.05a + +thymoma_lymphocyterich_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of expanded areas + which resemble the normal thymic cortex. The neoplastic epithelial cells are + small and scant and there is a dense T-lymphocytic component present. Areas + of medullary differentiation with or without Hassall's corpuscles are also present. + It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. + It has a low grade malignant potential. The majority of cases occur in the anterior + mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage + II tumors. + termDef: + term: >- + Thymoma Type B1 + source: NCIt + cde_id: C6887 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6887" + term_id: C6887 + term_version: 20.05a + +thymoma_lymphocytic_malignant: + common: + description: >- + A type B1 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B1 Thymoma + source: NCIt + cde_id: C7996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7996" + term_id: C7996 + term_version: 20.05a + +thymoma_lymphocytic_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of expanded areas + which resemble the normal thymic cortex. The neoplastic epithelial cells are + small and scant and there is a dense T-lymphocytic component present. Areas + of medullary differentiation with or without Hassall's corpuscles are also present. + It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. + It has a low grade malignant potential. The majority of cases occur in the anterior + mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage + II tumors. + termDef: + term: >- + Thymoma Type B1 + source: NCIt + cde_id: C6887 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6887" + term_id: C6887 + term_version: 20.05a + +thymoma_malignant_nos: + common: + description: >- + A thymoma that has an aggressive clinical course (capsular invasion, infiltration + of the surrounding tissues) and can metastasize. Although any morphologic subtype + of thymoma may eventually have a malignant clinical course, this term is most + often associated with thymoma types B3 and C. + termDef: + term: >- + Malignant Thymoma + source: NCIt + cde_id: C7612 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7612" + term_id: C7612 + term_version: 20.05a + +thymoma_medullary_malignant: + common: + description: >- + A type A thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type A Thymoma + source: NCIt + cde_id: C7999 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7999" + term_id: C7999 + term_version: 20.05a + +thymoma_medullary_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of spindle and/or + oval neoplastic epithelial cells. Lymphocytic infiltration is minimal or absent. + It may be associated with myasthenia gravis or pure red cell aplasia. The majority + of cases occur in the anterior mediastinum as Masaoka stage I tumors. Approximately + 20% of the cases occur as stage II or stage III tumors. Type A thymoma generally + behaves as a benign tumor and the overall survival is reported to be 100% at + 5 and 10 years. + termDef: + term: >- + Thymoma Type A + source: NCIt + cde_id: C6454 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6454" + term_id: C6454 + term_version: 20.05a + +thymoma_mixed_type_malignant: + common: + description: >- + A type AB thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type AB Thymoma + source: NCIt + cde_id: C6886 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6886" + term_id: C6886 + term_version: 20.05a + +thymoma_mixed_type_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of a lymphocyte-poor + component similar to that seen in type A thymoma and a lymphocyte-rich component + which contains neoplastic small polygonal epithelial cells. It may be associated + with myasthenia gravis and pure red cell aplasia. The majority of cases occur + in the anterior mediastinum as Masaoka stage I tumors. A minority of the cases + occur as stage II or stage III tumors. The overall survival is reported to be + 80-100% at 5 and 10 years. + termDef: + term: >- + Thymoma Type AB + source: NCIt + cde_id: C6885 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6885" + term_id: C6885 + term_version: 20.05a + +thymoma_nos: + common: + description: >- + A neoplasm arising from the epithelial cells of the thymus. Although thymomas + are usually encapsulated tumors, they may invade the capsule and infiltrate + the surrounding tissues or even metastasize to distant anatomic sites. The + following morphologic subtypes are currently recognized: type A, type B, type + AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas + type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually + has the most aggressive clinical course. + termDef: + term: >- + Thymoma + source: NCIt + cde_id: C3411 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3411" + term_id: C3411 + term_version: 20.05a + +thymoma_organoid_malignant: + common: + description: >- + A type B1 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B1 Thymoma + source: NCIt + cde_id: C7996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7996" + term_id: C7996 + term_version: 20.05a + +thymoma_organoid_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of expanded areas + which resemble the normal thymic cortex. The neoplastic epithelial cells are + small and scant and there is a dense T-lymphocytic component present. Areas + of medullary differentiation with or without Hassall's corpuscles are also present. + It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. + It has a low grade malignant potential. The majority of cases occur in the anterior + mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage + II tumors. + termDef: + term: >- + Thymoma Type B1 + source: NCIt + cde_id: C6887 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6887" + term_id: C6887 + term_version: 20.05a + +thymoma_predominantly_cortical_malignant: + common: + description: >- + A type B1 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B1 Thymoma + source: NCIt + cde_id: C7996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7996" + term_id: C7996 + term_version: 20.05a + +thymoma_predominantly_cortical_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of expanded areas + which resemble the normal thymic cortex. The neoplastic epithelial cells are + small and scant and there is a dense T-lymphocytic component present. Areas + of medullary differentiation with or without Hassall's corpuscles are also present. + It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. + It has a low grade malignant potential. The majority of cases occur in the anterior + mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage + II tumors. + termDef: + term: >- + Thymoma Type B1 + source: NCIt + cde_id: C6887 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6887" + term_id: C6887 + term_version: 20.05a + +thymoma_spindle_cell_malignant: + common: + description: >- + A type A thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type A Thymoma + source: NCIt + cde_id: C7999 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7999" + term_id: C7999 + term_version: 20.05a + +thymoma_spindle_cell_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of spindle and/or + oval neoplastic epithelial cells. Lymphocytic infiltration is minimal or absent. + It may be associated with myasthenia gravis or pure red cell aplasia. The majority + of cases occur in the anterior mediastinum as Masaoka stage I tumors. Approximately + 20% of the cases occur as stage II or stage III tumors. Type A thymoma generally + behaves as a benign tumor and the overall survival is reported to be 100% at + 5 and 10 years. + termDef: + term: >- + Thymoma Type A + source: NCIt + cde_id: C6454 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6454" + term_id: C6454 + term_version: 20.05a + +thymoma_type_a_malignant: + common: + description: >- + A type A thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type A Thymoma + source: NCIt + cde_id: C7999 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7999" + term_id: C7999 + term_version: 20.05a + +thymoma_type_a_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of spindle and/or + oval neoplastic epithelial cells. Lymphocytic infiltration is minimal or absent. + It may be associated with myasthenia gravis or pure red cell aplasia. The majority + of cases occur in the anterior mediastinum as Masaoka stage I tumors. Approximately + 20% of the cases occur as stage II or stage III tumors. Type A thymoma generally + behaves as a benign tumor and the overall survival is reported to be 100% at + 5 and 10 years. + termDef: + term: >- + Thymoma Type A + source: NCIt + cde_id: C6454 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6454" + term_id: C6454 + term_version: 20.05a + +thymoma_type_ab_malignant: + common: + description: >- + A type AB thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type AB Thymoma + source: NCIt + cde_id: C6886 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6886" + term_id: C6886 + term_version: 20.05a + +thymoma_type_ab_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of a lymphocyte-poor + component similar to that seen in type A thymoma and a lymphocyte-rich component + which contains neoplastic small polygonal epithelial cells. It may be associated + with myasthenia gravis and pure red cell aplasia. The majority of cases occur + in the anterior mediastinum as Masaoka stage I tumors. A minority of the cases + occur as stage II or stage III tumors. The overall survival is reported to be + 80-100% at 5 and 10 years. + termDef: + term: >- + Thymoma Type AB + source: NCIt + cde_id: C6885 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6885" + term_id: C6885 + term_version: 20.05a + +thymoma_type_b1_malignant: + common: + description: >- + A type B1 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B1 Thymoma + source: NCIt + cde_id: C7996 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7996" + term_id: C7996 + term_version: 20.05a + +thymoma_type_b1_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of expanded areas + which resemble the normal thymic cortex. The neoplastic epithelial cells are + small and scant and there is a dense T-lymphocytic component present. Areas + of medullary differentiation with or without Hassall's corpuscles are also present. + It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. + It has a low grade malignant potential. The majority of cases occur in the anterior + mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage + II tumors. + termDef: + term: >- + Thymoma Type B1 + source: NCIt + cde_id: C6887 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6887" + term_id: C6887 + term_version: 20.05a + +thymoma_type_b2_malignant: + common: + description: >- + A type B2 thymoma which is characterized by an aggressive clinical course (capsular + invasion, infiltration of the surrounding tissues) and can metastasize. + termDef: + term: >- + Malignant Type B2 Thymoma + source: NCIt + cde_id: C6889 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6889" + term_id: C6889 + term_version: 20.05a + +thymoma_type_b2_nos: + common: + description: >- + A thymic epithelial neoplasm characterized by the presence of neoplastic large, + polygonal epithelial cells with large vesicular nuclei and prominent nucleoli. + The neoplastic cells are arranged around perivascular spaces and along septa. + Immature T-lymphocytes are also present. It may be associated with myasthenia + gravis, pure red cell aplasia, and hypogammaglobulinemia. It is a tumor of moderate + malignancy. The majority of cases occur in the anterior mediastinum as Masaoka + stage I, stage II, or stage III tumors. Metastatic, stage IV tumors occur less + frequently. + termDef: + term: >- + Thymoma Type B2 + source: NCIt + cde_id: C6888 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6888" + term_id: C6888 + term_version: 20.05a + +thymoma_type_b3_malignant: + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +thymoma_type_b3_nos: + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +thymoma_type_c: + common: + description: >- + A diverse group of carcinomas of the thymus gland, previously known as thymoma + type C. It includes morphologic variants derived from purely epithelial cells, + as well as from cells with neuroendocrine differentiation. + termDef: + term: >- + Thymic Carcinoma + source: NCIt + cde_id: C7569 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7569" + term_id: C7569 + term_version: 20.05a + +thymus: + common: + description: >- + A bi-lobed organ surrounded by a connective tissue capsule. It is located in + the upper anterior portion of the chest, behind the sternum. It is composed + predominantly of lymphocytes and fewer epithelial cells. Connective tissue septa + separate the lobes into lobules. The lobules contain an outer portion (cortical + zone) which is rich in lymphocytes and an inner portion (medullary zone) which + is rich in epithelial cells. It is an organ essential for the development of + the immune system. Its function is the maturation of the progenitor lymphoid + cells to thymocytes and subsequently to mature T-cells. It reaches its greatest + weight at puberty and subsequently begins to involute. + termDef: + term: >- + Thymus Gland + source: NCIt + cde_id: C12433 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12433" + term_id: C12433 + term_version: 20.05a + +thyroid_cancer: + common: + description: >- + A carcinoma arising from the thyroid gland. It includes the following main subtypes: + follicular, papillary, medullary, poorly differentiated, and undifferentiated + (anaplastic) carcinoma. + termDef: + term: >- + Thyroid Gland Carcinoma + source: NCIt + cde_id: C4815 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4815" + term_id: C4815 + term_version: 19.12e + +thyroid_gland: + common: + description: >- + An endocrine gland located at the base of the neck that produces and secretes + thyroxine and other hormones. Thyroxine is important for metabolic control. + termDef: + term: >- + Thyroid Gland + source: NCIt + cde_id: C12400 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12400" + term_id: C12400 + term_version: 20.05a + +tibial_adamantinoma: + common: + description: >- + An adamantinoma arising from the tibia. The tibia is the site which is more + frequently involved by adamantinoma (80-90% of cases). + termDef: + term: >- + Tibial Adamantinoma + source: NCIt + cde_id: C8461 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8461" + term_id: C8461 + term_version: 20.05a + +tigit_inhibitor_m6223: + common: + description: >- + An inhibitor of T-cell immunoglobulin (Ig) and immunoreceptor tyrosine-based + inhibitory motif (ITIM) domains (TIGIT), a co-inhibitory molecule and immune + checkpoint inhibitor, with potential immune checkpoint inhibitory and antineoplastic + activities. Upon administration, TIGIT inhibitor M6223 targets and binds to + TIGIT expressed on various immune cells, particularly on tumor-infiltrating + T-lymphocytes (TILs), thereby preventing the interaction of TIGIT with its ligands + CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2) and CD155 (poliovirus + receptor; PVR; nectin-like protein 5; NECL-5). This enhances the interaction + of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; + DNAM-1), which is expressed on immune cells, such as natural killer (NK) cells + and CD8+ T-cells. This leads to CD226 dimerization and CD226-mediated signaling + and activates the immune system to exert a T-cell-mediated immune response against + cancer cells. TIGIT, a member of the Ig super family (IgSF) and an immune inhibitory + receptor, plays a key role in the suppression of T-cell proliferation and activation; + it is involved in tumor cell immune evasion, and the inhibition of antiviral + immune responses. + termDef: + term: >- + TIGIT Inhibitor M6223 + source: NCIt + cde_id: C173891 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173891" + term_id: C173891 + term_version: 20.10d + +tilogotamab: + common: + description: >- + An agonistic hexamer formation-enhanced mixture of two antibodies (HexaBody) + that target two separate epitopes on death receptor type 5 (DR5; TNFRSF10B; + tumor necrosis factor-related apoptosis-inducing ligand receptor 2; TRAILR2), + with potential antineoplastic activity. Upon administration, tilogotamab specifically + binds to and activates DR5. This results in the activation of caspase cascades + and the induction of apoptosis in DR5-expressing tumor cells. DR5, a cell surface + receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), + is involved in the promotion of caspase-dependent apoptosis. Compared to other + DR5 antibody-based agonists, the antibodies in GEN1029 (DR5-01 and DR5-05) elicit + increased receptor activation because they exhibit enhanced formation of antibody + hexamers and receptor clusters at the cell surface due to E430G mutations in + the Fc domains of both antibodies. + termDef: + term: >- + Tilogotamab + source: NCIt + cde_id: C153259 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C153259" + term_id: C153259 + term_version: 20.10d + +timorleste: + common: + description: >- + A country in southeastern Asia, northwest of Australia in the Lesser Sunda Islands + at the eastern end of the Indonesian archipelago. East Timor includes the eastern + half of the island of Timor, the Oecussi (Ambeno) region on the northwest portion + of the island of Timor, and the islands of Pulau Atauro and Pulau Jaco. + termDef: + term: >- + Timor-Leste + source: NCIt + cde_id: C17200 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17200" + term_id: C17200 + term_version: 19.12e + +tiomolibdate_choline: + common: + description: >- + An orally active second generation tetrathiomolybdate analog with anti-angiogenic + and antineoplastic activities. Tiomolibdate choline selectively chelates the + copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting + SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with + the activation of several signal transduction pathways required for cellular + proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and + Src kinases. This results in an inhibition of cell proliferation and angiogenesis + as well as induction of apoptosis. + termDef: + term: >- + Tiomolibdate Choline + source: NCIt + cde_id: C62514 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C62514" + term_id: C62514 + term_version: 20.10d + +tirbanibulin: + common: + description: >- + An orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic + activity. Unlike other Src kinase inhibitors which bind to the ATP-binding site, + tirbanibulin specifically binds to the peptide substrate binding site of Src + kinase; inhibition of kinase activity may result in the inhibition of primary + tumor growth and the suppression of metastasis. Src tyrosine kinases are upregulated + in many tumor cells and play important roles in tumor cell proliferation and + metastasis. + termDef: + term: >- + Tirbanibulin + source: NCIt + cde_id: C74077 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74077" + term_id: C74077 + term_version: 20.10d + +tis: + common: + description: >- + A term that refers to a TNM finding of a primary tumor microscopically defined + as carcinoma in situ. + termDef: + term: >- + Tis Stage Finding + source: NCIt + cde_id: C48738 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48738" + term_id: C48738 + term_version: 20.05a + +tis_dcis: + common: + description: >- + Breast cancer with a finding of ductal carcinoma in situ. Lobular carcinoma + in situ (LCIS) is a benign entity and is removed from TNM staging in the AJCC + Cancer Staging Manual, 8th Edition. (from AJCC 8th Ed.) + termDef: + term: >- + Breast Cancer pTis (DCIS) TNM Finding v8 + source: NCIt + cde_id: C139414 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C139414" + term_id: C139414 + term_version: 20.05a + +tis_lcis: + common: + description: >- + Breast cancer with a finding of lobular carcinoma in situ. (from AJCC 6th and + 7th Ed.) + termDef: + term: >- + Breast Cancer pTis (LCIS) TNM Finding v6 and v7 + source: NCIt + cde_id: C48976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48976" + term_id: C48976 + term_version: 20.05a + +tis_pagets: + common: + description: >- + Paget disease involving the skin overlying the mammary gland, without accompanying + invasive ductal or lobular breast carcinoma. + termDef: + term: >- + Paget Disease of the Breast without Invasive Carcinoma + source: NCIt + cde_id: C47858 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47858" + term_id: C47858 + term_version: 20.05a + +tissue_nos: + common: + description: >- + An anatomical structure consisting of similarly specialized cells and intercellular + matrix, aggregated according to genetically determined spatial relationships, + performing a specific function. + termDef: + term: >- + Tissue + source: NCIt + cde_id: C12801 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12801" + term_id: C12801 + term_version: 20.10d + +tlr7_agonist_bnt411: + common: + description: >- + A Toll-like receptor (TLR) 7 agonist with potential immunostimulating and antitumor + activities. Upon administration, TLR7 agonist BNT411 binds to and activates + TLR7. This may trigger, in addition to other possible responses, the activation + of cluster of differentiation (CD) 8+ T cells, B cells, and innate immune cells + including natural killer (NK) cells and macrophages. TLR7 is a member of the + TLR family, which plays a fundamental role in pathogen recognition and activation + of innate immunity. + termDef: + term: >- + TLR7 agonist BNT411 + source: NCIt + cde_id: C167350 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167350" + term_id: C167350 + term_version: 20.10d + +tlr7_agonist_lhc165: + common: + description: >- + A benzonapthyridine Toll-like receptor (TLR) 7 agonist that is adsorbed to aluminum + hydroxide with immunostimulating and potential antitumor activities. Upon intratumoral + administration of TLR7 agonist LHC165, the agent is slowly released and targets, + binds to and activates TLR7. This may trigger, in addition to other possible + responses, the activation of cluster of differentiation (CD) 8+ T cells and + natural killer (NK) cells, the blockage of the suppressive function of regulatory + T cells (Tregs), and the production of interferon alpha (IFNa). TLR7 is a member + of the TLR family, which plays a fundamental role in pathogen recognition and + activation of innate immunity. + termDef: + term: >- + TLR7 Agonist LHC165 + source: NCIt + cde_id: C166362 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C166362" + term_id: C166362 + term_version: 20.10d + +tlx1: + common: + description: >- + This gene plays a role in transcriptional regulation and organogenesis. Translocations + in the gene are associated with acute T-cell leukemia. + termDef: + term: >- + TLX1 Gene + source: NCIt + cde_id: C18608 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18608" + term_id: C18608 + term_version: 20.10d + +tlx3: + common: + description: >- + This gene may be involved in transcriptional regulation. + termDef: + term: >- + TLX3 Gene + source: NCIt + cde_id: C98099 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98099" + term_id: C98099 + term_version: 20.10d + +tm4sf1carepcamcarexpressing_autologous_t_cells: + common: + description: >- + A mixed preparation of allogeneic T-lymphocytes that have been genetically modified + to express either a chimeric antigen receptor (CAR) specific for the antigen + transmembrane 4 L six family member 1 (TM4SF1) (CART-TM4SF1) or a CAR specific + for epithelial cell adhesion molecule (EpCAM) (CART-EpCAM), with potential immunostimulating + and antineoplastic activities. Upon administration of the TM4SF1-CAR/EpCAM-CAR-expressing + autologous T cells, the TM4SF1-CAR-expressing autologous T-cells specifically + recognize and bind to TM4SF1-expressing tumor cells and the EpCAM-CAR-expressing + autologous T-cells specifically recognize and bind to EpCAM-expressing tumor + cells, resulting in tumor cell lysis. TM4SF1 and EpCAM are expressed by a variety + of tumor cells. + termDef: + term: >- + TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells + source: NCIt + cde_id: C173965 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173965" + term_id: C173965 + term_version: 20.10d + +tmem127: + common: + description: >- + This gene may play a role in signaling and protein trafficking. + termDef: + term: >- + TMEM127 Gene + source: NCIt + cde_id: C95303 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95303" + term_id: C95303 + term_version: 20.10d + +tmprss2: + common: + description: >- + This gene plays a role in the activation of pathway signaling. + termDef: + term: >- + TMPRSS2 Gene + source: NCIt + cde_id: C24871 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24871" + term_id: C24871 + term_version: 20.10d + +tnc: + common: + description: >- + This gene is involved in cell adhesion, differentiation and proliferation. + termDef: + term: >- + TNC Gene + source: NCIt + cde_id: C21091 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C21091" + term_id: C21091 + term_version: 20.10d + +tnfaip3: + common: + description: >- + This gene may play a role in the regulation of apoptosis. + termDef: + term: >- + TNFAIP3 Gene + source: NCIt + cde_id: C84928 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84928" + term_id: C84928 + term_version: 20.10d + +tnfrsf14: + common: + description: >- + This gene plays a role in receptor signaling. + termDef: + term: >- + TNFRSF14 Gene + source: NCIt + cde_id: C97843 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97843" + term_id: C97843 + term_version: 20.10d + +tnfrsf17: + common: + description: >- + This gene is involved in the modulation of cytokine signaling. + termDef: + term: >- + TNFRSF17 Gene + source: NCIt + cde_id: C97846 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97846" + term_id: C97846 + term_version: 20.10d + +tnkcell_lymphoma: + common: + description: >- + An aggressive, predominantly extranodal, mature T-cell non-Hodgkin lymphoma. + It is characterized by an often angiocentric and angiodestructive cellular infiltrate + composed of EBV positive NK/T cells. The nasal cavity is the most common site + of involvement. Patients often present with midfacial destructive lesions (lethal + midline granuloma). The disease may disseminate rapidly to various anatomic + sites including the gastrointestinal tract, skin, testis, and cervical lymph + nodes. It is also known as angiocentric T-cell lymphoma. The term "polymorphic + reticulosis" has been widely used to describe the morphologic changes seen in + this type of lymphoma. However, the latter term may also apply to lymphomatoid + granulomatosis, which is an angiocentric and angiodestructive EBV positive B-cell + lymphoproliferative disorder. + termDef: + term: >- + Nasal Type Extranodal NK/T-Cell Lymphoma + source: NCIt + cde_id: C4684 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4684" + term_id: C4684 + term_version: 20.05a + +tobacco: + common: + description: >- + The dried cured leaves of the tobacco plant, Nicotiana tabacum, used for smoking, + chewing, or snuff. Tobacco contains nicotine, a stimulant, and other biologically + active ingredients having carcinogenic properties. + termDef: + term: >- + Tobacco + source: NCIt + cde_id: C891 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C891" + term_id: C891 + term_version: 19.12e + +tobacco_smoke_cigar: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced by direct or nearby use of a cigar. + termDef: + term: >- + Cigar Smoke Exposure + source: NCIt + cde_id: C164097 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164097" + term_id: C164097 + term_version: 19.12e + +tobacco_smoke_cigarettes: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced by direct or nearby use of a cigarette. + termDef: + term: >- + Cigarette Smoke Exposure + source: NCIt + cde_id: C164098 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164098" + term_id: C164098 + term_version: 19.12e + +tobacco_smoke_pipe: + common: + description: >- + Environmental, occupational or consumer-based exposure to airborne gases and + particulates produced by direct or nearby use of a tobacco pipe. + termDef: + term: >- + Tobacco Pipe Smoke Exposure + source: NCIt + cde_id: C164099 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164099" + term_id: C164099 + term_version: 19.12e + +togo: + common: + description: >- + A country in western Africa, bordering the Gulf of Guinea, between Benin and + Ghana. + termDef: + term: >- + Togo + source: NCIt + cde_id: C17202 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17202" + term_id: C17202 + term_version: 19.12e + +tokelau: + common: + description: >- + A group of three atolls in the South Pacific Ocean, about one-half of the way + from Hawaii to New Zealand, west of Tuvalu and north of American Samoa. + termDef: + term: >- + Tokelau + source: NCIt + cde_id: C17704 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17704" + term_id: C17704 + term_version: 19.12e + +tolebrutinib: + common: + description: >- + An orally bioavailable, brain-penetrant, selective, small molecule inhibitor + of Bruton's tyrosine kinase (BTK), with potential immunomodulatory and anti-inflammatory + activities. Upon oral administration, tolebrutinib is able to cross the blood-brain + barrier and inhibits the activity of BTK both peripherally and in the central + nervous system (CNS). This prevents the activation of the B-cell antigen receptor + (BCR) signaling pathway, and the resulting immune activation and inflammation. + The inhibition of BTK activity also prevents microglial inflammatory signaling + in the CNS, and the resulting immune activation, neuroinflammation and neurodegeneration. + BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, + plays an important role in B lymphocyte development, activation, signaling, + proliferation and survival. In addition to B cells, BTK is also expressed in + innate immune cells, including macrophages and microglia, and plays an important + role in the regulation of microglial inflammatory signaling. + termDef: + term: >- + Tolebrutinib + source: NCIt + cde_id: C173549 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173549" + term_id: C173549 + term_version: 20.10d + +tonga: + common: + description: >- + An archipelago in the South Pacific Ocean, about two-thirds of the way from + Hawaii to New Zealand, southeast of Fiji. + termDef: + term: >- + Tonga + source: NCIt + cde_id: C17205 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17205" + term_id: C17205 + term_version: 19.12e + +tongue_cancer: + common: + description: >- + A malignant tumor arising from the epithelium that covers the tongue. The vast + majority of tongue carcinomas are moderately or poorly differentiated squamous + cell carcinomas. + termDef: + term: >- + Tongue Carcinoma + source: NCIt + cde_id: C4824 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4824" + term_id: C4824 + term_version: 19.12e + +tongue_nos: + common: + description: >- + The muscular organ located in the floor of the mouth and serving as the principal + organ of taste and modification of the voice in speech. + termDef: + term: >- + Tongue + source: NCIt + cde_id: C12422 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12422" + term_id: C12422 + term_version: 20.05a + +tonsil_nos: + common: + description: >- + Two masses of lymphatic tissue located one on either side of the oropharynx + in the oropharyngeal isthmus. + termDef: + term: >- + Palatine Tonsil + source: NCIt + cde_id: C33250 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33250" + term_id: C33250 + term_version: 20.05a + +tonsillar_cancer: + common: + description: >- + A carcinoma arising from the tonsilar epithelium. + termDef: + term: >- + Tonsillar Carcinoma + source: NCIt + cde_id: C4825 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4825" + term_id: C4825 + term_version: 19.12e + +tonsillar_fossa: + common: + description: >- + A triangular shaped space that lies on each side of the oropharynx and houses + the palatine tonsils. + termDef: + term: >- + Tonsillar Fossa + source: NCIt + cde_id: C12235 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12235" + term_id: C12235 + term_version: 20.05a + +tonsillar_pillar: + common: + description: >- + The anterior and posterior borders of the tonsillar fossa. They are composed + of muscle tissue. + termDef: + term: >- + Tonsillar Pillar + source: NCIt + cde_id: C12236 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12236" + term_id: C12236 + term_version: 20.05a + +top1: + common: + description: >- + This gene is involved in the regulation of both DNA topology and transcription. + termDef: + term: >- + TOP1 Gene + source: NCIt + cde_id: C26591 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26591" + term_id: C26591 + term_version: 20.10d + +topotecan_sustainedrelease_episcleral_plaque: + common: + description: >- + An episcleral plaque containing sustained-release (SR) topotecan, a semisynthetic + derivative of camptothecin and a cytotoxic, quinoline-based alkaloid extracted + from the Asian tree Camptotheca acuminate, with potential antineoplastic activity. + Upon local application of the topotecan SR episcleral plaque to the eye, topotecan + is released in a sustained manner and inhibits topoisomerase I activity by stabilizing + the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby + inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and + producing potentially lethal double-strand DNA breaks when encountered by the + DNA replication machinery. The episcleral plaque allows for local delivery of + topotecan for the potential treatment of retinoblastoma. + termDef: + term: >- + Topotecan Sustained-release Episcleral Plaque + source: NCIt + cde_id: C173363 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173363" + term_id: C173363 + term_version: 20.10d + +total_bilirubin: + common: + description: >- + The measurement of the total amount of bilirubin present in a particular substrate. + The substrate most often tested is blood, but other fluids extracted from the + body may be used periodically depending on the purpose of the test. + termDef: + term: >- + Total Bilirubin Measurement + source: NCIt + cde_id: C38037 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38037" + term_id: C38037 + term_version: 20.10d + +total_protein: + common: + description: >- + A quantitative measurement of the total amount of protein present in a sample + of serum. + termDef: + term: >- + Serum Total Protein Measurement + source: NCIt + cde_id: C61033 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61033" + term_id: C61033 + term_version: 20.10d + +total_rna: + common: + description: >- + A biological sample comprised of all of the RNA collected from an experimental + subject. + termDef: + term: >- + Total RNA + source: NCIt + cde_id: C163995 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C163995" + term_id: C163995 + term_version: 20.10d + +toxicity: + common: + description: >- + The finding of bodily harm due to the poisonous effects of something. + termDef: + term: >- + Toxicity + source: NCIt + cde_id: C27990 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27990" + term_id: C27990 + term_version: 19.12e + +tp53: + common: + description: >- + This gene plays a critical role in cell cycle regulation and has tumor suppressor + activity. + termDef: + term: >- + TP53 Gene + source: NCIt + cde_id: C17359 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17359" + term_id: C17359 + term_version: 20.10d + +tp63: + common: + description: >- + This gene plays a role in both transcriptional regulation and limb development. + termDef: + term: >- + TP63 Gene + source: NCIt + cde_id: C91791 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C91791" + term_id: C91791 + term_version: 20.10d + +tpm3: + common: + description: >- + This gene plays a role in muscle contraction. + termDef: + term: >- + TPM3 Gene + source: NCIt + cde_id: C97849 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97849" + term_id: C97849 + term_version: 20.10d + +tpm4: + common: + description: >- + This gene is involved in smooth muscle cell contraction. + termDef: + term: >- + TPM4 Gene + source: NCIt + cde_id: C97852 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97852" + term_id: C97852 + term_version: 20.10d + +tpr: + common: + description: >- + This gene plays a role in both nuclear transport and mitosis. + termDef: + term: >- + TPR Gene + source: NCIt + cde_id: C97855 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97855" + term_id: C97855 + term_version: 20.10d + +tra: + common: + description: >- + This region represents the germline organization of the T cell receptor alpha + locus. The alpha locus includes V (variable), J (joining), and C (constant) + segments. During T cell development, the alpha chain is synthesized by a recombination + event at the DNA level joining a V segment with a J segment. The C segment is + later joined by splicing at the RNA level. Recombination of many different V + segments with several J segments provides a wide range of antigen recognition. + Additional diversity is attained by junctional diversity, resulting from the + random additional of nucleotides by terminal deoxynucleotidyltransferase. (from + LocusLink) + termDef: + term: >- + T-Cell Receptor Alpha Locus + source: NCIt + cde_id: C26419 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26419" + term_id: C26419 + term_version: 20.10d + +trabecular_adenocarcinoma: + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of a trabecular + glandular architectural pattern. + termDef: + term: >- + Trabecular Adenocarcinoma + source: NCIt + cde_id: C4068 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4068" + term_id: C4068 + term_version: 20.05a + +trabecular_adenoma: + common: + description: >- + A benign epithelial neoplasm characterized by the presence of a trabecular glandular + architectural pattern. + termDef: + term: >- + Trabecular Adenoma + source: NCIt + cde_id: C3688 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3688" + term_id: C3688 + term_version: 20.05a + +trabecular_carcinoma: + common: + description: >- + A malignant epithelial neoplasm characterized by the presence of a trabecular + glandular architectural pattern. + termDef: + term: >- + Trabecular Adenocarcinoma + source: NCIt + cde_id: C4068 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4068" + term_id: C4068 + term_version: 20.05a + +trachea: + common: + description: >- + The fibrocartilaginous, mucous-lined tube passing from the larynx to the bronchi. + termDef: + term: >- + Trachea + source: NCIt + cde_id: C12428 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12428" + term_id: C12428 + term_version: 20.05a + +traditional_serrated_adenoma: + common: + description: >- + An adenoma that arises from the large intestine and the appendix. It is characterized + by prominent serration of the glands and the presence of generalized low-grade + dysplasia. + termDef: + term: >- + Traditional Serrated Adenoma + source: NCIt + cde_id: C38458 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38458" + term_id: C38458 + term_version: 20.05a + +traf7: + common: + description: >- + This gene is involved in both MAPK signaling and protein ubiquitination. + termDef: + term: >- + TRAF7 Gene + source: NCIt + cde_id: C107646 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C107646" + term_id: C107646 + term_version: 20.10d + +transcript_ablation: + common: + description: >- + Any deletion mutation that occurs within a gene, including the 5' and 3' untranslated + regions of the gene. + termDef: + term: >- + Gene Deletion + source: NCIt + cde_id: C16606 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16606" + term_id: C16606 + term_version: 20.10d + +transcript_amplification: + common: + description: >- + An increase in the copy number of a particular gene. This type of abnormality + can be either inherited or somatic. + termDef: + term: >- + Gene Amplification Abnormality + source: NCIt + cde_id: C45581 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C45581" + term_id: C45581 + term_version: 20.10d + +transferrincrm107: + common: + description: >- + A synthetic targeted protein toxin which consists of human transferrin (Tf) + conjugated to a diphtheria toxin that contains a point mutation (CRM107). After + binding to the transferrin receptor expressed on the tumor cell surface, transferrin-CRM107 + is internalized, where the diphtheria toxin moiety exerts its cytotoxic effect + intracellularly by inhibiting protein synthesis through ADP-ribosylation of + elongation factor. (NCI04) + termDef: + term: >- + Transferrin-CRM107 + source: NCIt + cde_id: C26676 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26676" + term_id: C26676 + term_version: 20.10d + +transient_abnormal_myelopoiesis: + common: + description: >- + A myeloid proliferation occurring in newborns with Down syndrome. It is clinically + and morphologically indistinguishable from acute myeloid leukemia and is associated + with GATA1 mutations. The blasts display morphologic and immunophenotypic features + of megakaryocytic lineage. In the majority of patients the myeloid proliferation + undergoes spontaneous remission. + termDef: + term: >- + Transient Abnormal Myelopoiesis Associated with Down Syndrome + source: NCIt + cde_id: C82339 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C82339" + term_id: C82339 + term_version: 20.05a + +transitional_carcinoma: + common: + description: >- + A malignant neoplasm arising from the transitional epithelium, usually affecting + the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary + configuration. It is graded 1 to 3 or 4 according to the degree of cellular + differentiation and architectural patterns. Grade 1 transitional cell carcinoma + is histologically benign but it may recur. Transitional cell carcinomas may + also affect the upper respiratory tract and the ovaries. + termDef: + term: >- + Transitional Cell Carcinoma + source: NCIt + cde_id: C2930 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2930" + term_id: C2930 + term_version: 20.05a + +transitional_cell_carcinoma: + common: + description: >- + A malignant neoplasm arising from the transitional epithelium, usually affecting + the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary + configuration. It is graded 1 to 3 or 4 according to the degree of cellular + differentiation and architectural patterns. Grade 1 transitional cell carcinoma + is histologically benign but it may recur. Transitional cell carcinomas may + also affect the upper respiratory tract and the ovaries. + termDef: + term: >- + Transitional Cell Carcinoma + source: NCIt + cde_id: C2930 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2930" + term_id: C2930 + term_version: 20.05a + +transitional_cell_carcinoma_in_situ: + common: + description: >- + A lesion in which the surface epithelium of the bladder or the renal pelvis + and ureter contains transitional cells which display malignant cytologic characteristics. There + is no evidence of stromal invasion. + termDef: + term: >- + Stage 0 Transitional Cell Carcinoma + source: NCIt + cde_id: C4116 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4116" + term_id: C4116 + term_version: 20.05a + +transitional_cell_carcinoma_micropapillary: + common: + description: >- + A transitional cell carcinoma characterized by a micropapillary growth pattern. + Typical example is the micropapillary variant of infiltrating bladder urothelial + carcinoma. + termDef: + term: >- + Micropapillary Transitional Cell Carcinoma + source: NCIt + cde_id: C65182 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65182" + term_id: C65182 + term_version: 20.05a + +transitional_cell_carcinoma_sarcomatoid: + common: + description: >- + A poorly differentiated transitional cell carcinoma characterized by the presence + of malignant cells with spindle cell morphologic features. + termDef: + term: >- + Sarcomatoid Transitional Cell Carcinoma + source: NCIt + cde_id: C4120 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4120" + term_id: C4120 + term_version: 20.05a + +transitional_cell_carcinoma_spindle_cell: + common: + description: >- + A poorly differentiated transitional cell carcinoma characterized by the presence + of malignant cells with spindle cell morphologic features. + termDef: + term: >- + Sarcomatoid Transitional Cell Carcinoma + source: NCIt + cde_id: C4120 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4120" + term_id: C4120 + term_version: 20.05a + +transitional_cell_papilloma_benign: + common: + description: >- + A benign papillary neoplasm composed of transitional cells which show preservation + of the nuclear polarity. + termDef: + term: >- + Transitional Cell Papilloma + source: NCIt + cde_id: C4115 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4115" + term_id: C4115 + term_version: 20.05a + +transitional_cell_papilloma_inverted_benign: + common: + description: >- + A benign papillary neoplasm composed of transitional cells and characterized + by an endophytic growth pattern. + termDef: + term: >- + Inverted Transitional Cell Papilloma + source: NCIt + cde_id: C4118 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4118" + term_id: C4118 + term_version: 20.05a + +transitional_cell_papilloma_inverted_nos: + common: + description: >- + A benign papillary neoplasm composed of transitional cells and characterized + by an endophytic growth pattern. + termDef: + term: >- + Inverted Transitional Cell Papilloma + source: NCIt + cde_id: C4118 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4118" + term_id: C4118 + term_version: 20.05a + +transitional_cell_papilloma_nos: + common: + description: >- + A benign papillary neoplasm composed of transitional cells which show preservation + of the nuclear polarity. + termDef: + term: >- + Transitional Cell Papilloma + source: NCIt + cde_id: C4115 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4115" + term_id: C4115 + term_version: 20.05a + +transitional_meningioma: + common: + description: >- + A WHO grade I meningioma characterized by the coexistence of meningothelial + cells and fibrous architectural patterns. + termDef: + term: >- + Transitional Meningioma + source: NCIt + cde_id: C4333 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4333" + term_id: C4333 + term_version: 20.05a + +transitional_papilloma: + common: + description: >- + A benign papillary neoplasm composed of transitional cells which show preservation + of the nuclear polarity. + termDef: + term: >- + Transitional Cell Papilloma + source: NCIt + cde_id: C4115 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4115" + term_id: C4115 + term_version: 20.05a + +transitional_papilloma_inverted_benign: + common: + description: >- + A benign papillary neoplasm composed of transitional cells and characterized + by an endophytic growth pattern. + termDef: + term: >- + Inverted Transitional Cell Papilloma + source: NCIt + cde_id: C4118 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4118" + term_id: C4118 + term_version: 20.05a + +transitional_papilloma_inverted_nos: + common: + description: >- + A benign papillary neoplasm composed of transitional cells and characterized + by an endophytic growth pattern. + termDef: + term: >- + Inverted Transitional Cell Papilloma + source: NCIt + cde_id: C4118 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4118" + term_id: C4118 + term_version: 20.05a + +translocation: + common: + description: >- + A genetic exchange where a piece of one chromosome is transferred to another + chromosome. + termDef: + term: >- + Chromosomal Translocation + source: NCIt + cde_id: C3420 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3420" + term_id: C3420 + term_version: 20.10d + +transverse_colon: + common: + description: >- + The third division of the colon (large intestine). It communicates with the + ascending colon in the upper right-hand quadrant of the abdomen and the descending + colon in the upper left-hand quadrant. + termDef: + term: >- + Transverse Colon + source: NCIt + cde_id: C12385 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12385" + term_id: C12385 + term_version: 20.05a + +trastuzumab_deruxtecan: + common: + description: >- + An antibody-drug conjugate (ADC) composed of trastuzumab, a monoclonal antibody + targeting human epidermal growth factor receptor 2 (ERBB2; EGFR2; HER2) conjugated + to deruxtecan, a derivative of the camptothecin analog exatecan (DXd; DX-8951 + derivative), a DNA topoisomerase 1 (topoisomerase I; Top1) inhibitor, with antineoplastic + activity. Upon administration of trastuzumab deruxtecan, trastuzumab targets + and binds to HER2 on tumor cells. Upon antibody/antigen binding and internalization, + deruxtecan binds to and inhibits Top1-DNA complexes, which results in an inhibition + of DNA replication, cell cycle arrest and tumor cell apoptosis. HER2, a tyrosine + kinase receptor, is overexpressed by many cancer cell types. In addition, trastuzumab + deruxtecan induces antibody-dependent cell-mediated cytotoxicity (ADCC) and + causes a bystander killing effect. + termDef: + term: >- + Trastuzumab Deruxtecan + source: NCIt + cde_id: C128799 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C128799" + term_id: C128799 + term_version: 20.10d + +trastuzumab_monomethyl_auristatin_f: + common: + description: >- + An antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal + growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to + the auristatin analog and potent microtubule inhibitor monomethyl auristatin + F (MMAF), with potential antineoplastic activity. Upon administration of trastuzumab + monomethyl auristatin F, the trastuzumab moiety binds to HER2 on tumor cell + surfaces; upon internalization, the MMAF moiety binds to and inhibits tubulin + polymerization, which results in G2/M phase arrest and tumor cell apoptosis. + HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. + termDef: + term: >- + Trastuzumab Monomethyl Auristatin F + source: NCIt + cde_id: C172821 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172821" + term_id: C172821 + term_version: 20.10d + +trastuzumabtlr_78_agonist_bdc1001: + common: + description: >- + An immune stimulating antibody conjugate (ISAC) consisting of trastuzumab, an + anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody, conjugated + to a Toll-like receptor (TLR) 7/8 dual agonist, with potential immunostimulating + and antineoplastic activities. Upon administration of trastuzumab-TLR 7/8 agonist + BDC-1001, the trastuzumab moiety targets and binds to HER2 expressed on tumor + cells and, simultaneously, the TLR 7/8 dual agonist moiety targets, binds to + and activates TLR7/8 expressed on antigen-presenting cells (APCs), specifically + dendritic cells (DCs), in the tumor microenvironment (TME). The trastuzumab + binding to the tumor cells causes the engulfment of the BDC-1001-bound tumor + cells by tumor-associated myeloid (TAM) cells and the TAMs travel to the lymph + nodes. The DCs activated by the TLR7/8 agonist causes the activation of TLR7/8-mediated + pathways, and stimulates the maturation and activation of DCs, thereby re-activating + the immune system against the tumor cells. Activation of DCs results in the + production of pro-inflammatory cytokines, and the activation of cytotoxic T-lymphocyte + (CTL)- and B-lymphocyte-mediated immune responses against tumor-associated antigens + (TAAs), which lead to tumor cell lysis. TLR7 and 8, members of the TLR family, + play fundamental roles in the activation of the innate immune system, myeloid + cell responses and tumor antigen presentation. HER2 is overexpressed by a variety + of tumor cell types. + termDef: + term: >- + Trastuzumab-TLR 7/8 Agonist BDC-1001 + source: NCIt + cde_id: C172388 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172388" + term_id: C172388 + term_version: 20.10d + +trb: + common: + description: >- + This region represents the germline organization of the T cell receptor beta + locus. The beta locus includes V (variable), J (joining), diversity (D), and + C (constant) segments. During T cell development, the beta chain is synthesized + by a recombination event at the DNA level joining a D segment with a J segment; + a V segment is then joined to the D-J gene. The C segment is later joined by + splicing at the RNA level. Recombination of many different V segments with several + D and J segments provides a wide range of antigen recognition. Additional diversity + is attained by junctional diversity, resulting from the random additional of + nucleotides by terminal deoxynucleotidyltransferase. Chromosomal abnormalities + involving the T-cell receptor beta locus have been associated with T-cell lymphomas. + (from LocusLink) + termDef: + term: >- + T-Cell Receptor Beta Locus + source: NCIt + cde_id: C26418 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26418" + term_id: C26418 + term_version: 20.10d + +trd: + common: + description: >- + This region represents the germline organization of the T cell receptordelta + locus. The delta locus includes V (variable), J (joining), diversity (D), and + C (constant) segments. During T cell development, the delta chain is synthesized + by a recombination event at the DNA level joining a D segment with a J segment; + a V segment is then joined to the D-J gene. The C segment is later joined by + splicing at the RNA level. Recombination of many different V segments with several + D and J segments provides a wide range of antigen recognition. Additional diversity + is attained by junctional diversity, resulting from the random additional of + nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink) + termDef: + term: >- + T-Cell Receptor Delta Locus + source: NCIt + cde_id: C26420 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26420" + term_id: C26420 + term_version: 20.10d + +trichilemmal_carcinoma: + common: + description: >- + A rare malignant tumor arising from the outer hair sheath and infundibulum on + the face. It is considered the malignant counterpart of tricholemmoma. Complete + surgical excision is required. + termDef: + term: >- + Trichilemmal Carcinoma + source: NCIt + cde_id: C43326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43326" + term_id: C43326 + term_version: 20.05a + +trichilemmocarcinoma: + common: + description: >- + A rare malignant tumor arising from the outer hair sheath and infundibulum on + the face. It is considered the malignant counterpart of tricholemmoma. Complete + surgical excision is required. + termDef: + term: >- + Trichilemmal Carcinoma + source: NCIt + cde_id: C43326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43326" + term_id: C43326 + term_version: 20.05a + +trichilemmoma: + common: + description: >- + A benign neoplasm arising from the outer hair sheath and infundibulum. It occurs + in the head and neck, usually on the face. It usually presents as an exophytic + wart-like lesion or a dome-shaped lesion with smooth surface. Multiple facial + lesions are usually associated with Cowden disease. + termDef: + term: >- + Trichilemmoma + source: NCIt + cde_id: C4113 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4113" + term_id: C4113 + term_version: 20.05a + +trichodiscoma: + common: + description: >- + A benign tumor usually arising in the face, trunk or thighs. + termDef: + term: >- + Spindle-Cell Predominant Trichodiscoma + source: NCIt + cde_id: C43333 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43333" + term_id: C43333 + term_version: 20.05a + +trichoepithelioma: + common: + description: >- + A benign hair follicle neoplasm with trichoblastic differentiation. It usually + presents as a solitary papular lesion It most often presents on the head and + neck area, but it may develop in any anatomic site containing hair follicles. + Because of its benign nature, treatment usually is not required, provided that + the diagnosis has been established with certainty. + termDef: + term: >- + Trichoblastoma + source: NCIt + cde_id: C27132 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27132" + term_id: C27132 + term_version: 20.05a + +trichofolliculoma: + common: + description: >- + A skin appendage neoplasm with follicular differentiation. It usually occurs + in the head and neck region, particularly the face. It presents as a solitary + dome-shaped small lesion. The clinical course is benign. + termDef: + term: >- + Trichofolliculoma + source: NCIt + cde_id: C4112 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4112" + term_id: C4112 + term_version: 20.05a + +trigone_of_bladder: + common: + description: >- + The triangular area in the bladder mucosa that is formed by the two ureteral + orifices and the urethral orifice. + termDef: + term: >- + Bladder Trigone + source: NCIt + cde_id: C12331 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12331" + term_id: C12331 + term_version: 20.05a + +trim24: + common: + description: >- + This gene plays a role in hormone-dependent gene transcription. + termDef: + term: >- + TRIM24 Gene + source: NCIt + cde_id: C95280 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C95280" + term_id: C95280 + term_version: 20.10d + +trim27: + common: + description: >- + This gene is involved in the differentiation of male germ cells. + termDef: + term: >- + TRIM27 Gene + source: NCIt + cde_id: C24733 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24733" + term_id: C24733 + term_version: 20.10d + +trim33: + common: + description: >- + This gene is involved in the mediation of protein ubiquitination. + termDef: + term: >- + TRIM33 Gene + source: NCIt + cde_id: C97858 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97858" + term_id: C97858 + term_version: 20.10d + +trinidad_and_tobago: + common: + description: >- + A group of islands between the Caribbean Sea and the North Atlantic Ocean, off + the northeast coast of Venezuela. + termDef: + term: >- + Trinidad and Tobago + source: NCIt + cde_id: C17217 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17217" + term_id: C17217 + term_version: 19.12e + +trip11: + common: + description: >- + This gene plays a role in thyroid receptor binding. + termDef: + term: >- + TRIP11 Gene + source: NCIt + cde_id: C97861 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97861" + term_id: C97861 + term_version: 20.10d + +trisacryl_gelatin_microspheres: + common: + description: >- + An embolic particle composed of water-soluble, compressible, nonabsorbable microspheres + composed of tris-acryl gelatin, with potential use for embolization. Upon administration, + the tris-acryl gelatin microspheres (TAGM) serve as an embolic agent before + surgery for highly vascularized areas, such as those seen in certain tumors, + by penetrating into the blood vessel system and blocking blood flow. These microspheres + may be used to encapsulate various therapeutic agents; drug-loaded microspheres + can then be used as drug delivery vehicles during embolization of tumor vasculature. + termDef: + term: >- + Tris-acryl Gelatin Microspheres + source: NCIt + cde_id: C126803 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126803" + term_id: C126803 + term_version: 20.10d + +triton_tumor_malignant: + common: + description: >- + A malignant peripheral nerve sheath tumor which shows rhabdomyosarcomatous differentiation. + More than half of the patients have neurofibromatosis type 1. The prognosis + is usually poor. + termDef: + term: >- + Malignant Triton Tumor + source: NCIt + cde_id: C4335 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4335" + term_id: C4335 + term_version: 20.05a + +trk_inhibitor_tqb3558: + common: + description: >- + An orally available inhibitor of tropomyosin receptor kinase (Trk), with potential + antineoplastic activity. Upon oral administration, Trk inhibitor TQB3558 targets + and binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation. + This may lead to apoptosis of Trk-expressing tumor cells and the inhibition + of tumor cell proliferation in Trk-expressing tumors. Trk, a receptor tyrosine + kinase activated by neurotrophins, is mutated in a variety of cancer cell types + and plays an important role in tumor cell growth and survival. + termDef: + term: >- + TRK Inhibitor TQB3558 + source: NCIt + cde_id: C173560 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173560" + term_id: C173560 + term_version: 20.10d + +trophoblastic_tumor_epithelioid: + common: + description: >- + A gestational trophoblastic tumor characterized by the presence of a monomorphous + cellular population of intermediate trophoblastic cells infiltrating in a nodular + pattern. + termDef: + term: >- + Epithelioid Trophoblastic Tumor + source: NCIt + cde_id: C6900 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6900" + term_id: C6900 + term_version: 20.05a + +troriluzole: + common: + description: >- + A formulation comprised of a prodrug form of the benzothiazole derivative riluzole, + with potential anti-depressant, anxiolytic and antineoplastic activities. Following + oral administration, troriluzole is converted into the active form riluzole. + While the mechanism of action of riluzole is unknown, its pharmacological activities, + some of which may be related to its effect, include the following: 1) an inhibitory + effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, + and 3) interference with intracellular events that follow transmitter binding + at excitatory amino acid receptors. These activities may result in myorelaxation + and sedation due to the blockade of glutamatergic neurotransmission. Additionally, + these activities may result in the inhibition of enzymes that are necessary + for cell growth, which may decrease tumor cell growth and metastasis. + termDef: + term: >- + Troriluzole + source: NCIt + cde_id: C142847 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C142847" + term_id: C142847 + term_version: 20.10d + +trrap: + common: + description: >- + This gene is involved in DNA repair and regulation of mitosis. + termDef: + term: >- + TRRAP Gene + source: NCIt + cde_id: C24880 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24880" + term_id: C24880 + term_version: 20.10d + +true_histiocytic_lymphoma: + common: + description: >- + An antiquated term referring to large cell lymphomas. + termDef: + term: >- + True Histiocytic Lymphoma + source: NCIt + cde_id: C35382 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35382" + term_id: C35382 + term_version: 20.05a + +tsc1: + common: + description: >- + This gene is involved in cell cycle regulation and the loss of cellular adhesion. + termDef: + term: >- + TSC1 Gene + source: NCIt + cde_id: C18259 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18259" + term_id: C18259 + term_version: 20.10d + +tsc2: + common: + description: >- + This gene plays a role in signal transduction and cell cycle control. It is + involved in cell adhesion, differentiation, growth and migration. + termDef: + term: >- + TSC2 Gene + source: NCIt + cde_id: C18260 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18260" + term_id: C18260 + term_version: 20.10d + +tshr: + common: + description: >- + This gene plays an important role in the regulation of thyroid cell metabolism. + termDef: + term: >- + TSHR Gene + source: NCIt + cde_id: C24881 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24881" + term_id: C24881 + term_version: 20.10d + +tubular: + common: + description: >- + A morphological appearance characteristic of neoplasms which arise from the + glandular or ductal (or both) epithelium, consisting of glandular or ductal + neoplastic proliferations forming small tubules with a lumen lined by neoplastic + cells. + termDef: + term: >- + Tubular Pattern + source: NCIt + cde_id: C35925 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35925" + term_id: C35925 + term_version: 20.10d + +tubular_adenocarcinoma: + common: + description: >- + An infiltrating adenocarcinoma in which the malignant cells form tubular structures. + Representative examples include the tubular breast carcinoma and the gastric + tubular adenocarcinoma. + termDef: + term: >- + Tubular Adenocarcinoma + source: NCIt + cde_id: C65192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65192" + term_id: C65192 + term_version: 20.05a + +tubular_adenoma_nos: + common: + description: >- + A usually polypoid neoplasm arising from the glandular epithelium. It is characterized + by a tubular architectural pattern. The neoplastic glandular cells have dysplastic + features. Representative examples include the tubular adenomas of the colon + and rectum. + termDef: + term: >- + Tubular Adenoma + source: NCIt + cde_id: C4133 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4133" + term_id: C4133 + term_version: 20.05a + +tubular_androblastoma_nos: + common: + description: >- + A sex cord-stromal tumor of the testis or the ovary. It is characterized by + the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. + It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom + is a slow growing testicular mass. Most cases follow a benign clinical course. + In females it may present with estrogenic or androgenic manifestations. The + vast majority of cases have a benign clinical course. + termDef: + term: >- + Sertoli Cell Tumor + source: NCIt + cde_id: C39976 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39976" + term_id: C39976 + term_version: 20.05a + +tubular_carcinoma: + common: + description: >- + An infiltrating adenocarcinoma in which the malignant cells form tubular structures. + Representative examples include the tubular breast carcinoma and the gastric + tubular adenocarcinoma. + termDef: + term: >- + Tubular Adenocarcinoma + source: NCIt + cde_id: C65192 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65192" + term_id: C65192 + term_version: 20.05a + +tubulocystic_renal_cell_carcinoma: + common: + description: >- + A rare, cytologically high grade carcinoma that arises from the renal parenchyma. + It is characterized by the presence of prominently dilated cystic spaces in + a bland, fibrotic stroma. The lining cells have large irregular nuclei with + prominent nucleoli and abundant eosinophilic cytoplasm. Necrosis and mitotic + figures are not present. It rarely metastasizes. + termDef: + term: >- + Tubulocystic Renal Cell Carcinoma + source: NCIt + cde_id: C126303 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126303" + term_id: C126303 + term_version: 20.05a + +tubulolobular_carcinoma: + common: + description: >- + An invasive lobular carcinoma of the breast, characterized by the presence of + neoplastic cells forming small tubular structures. + termDef: + term: >- + Invasive Lobular Breast Carcinoma, Tubulolobular Variant + source: NCIt + cde_id: C97053 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97053" + term_id: C97053 + term_version: 20.05a + +tubulopapillary_adenoma: + common: + description: >- + An epithelial neoplasm morphologically characterized by the presence of a villous + and a tubular architectural pattern. Most often it occurs in the large intestine, + small intestine, and the stomach in which the neoplastic epithelial cells show + dysplastic features. + termDef: + term: >- + Tubulovillous Adenoma + source: NCIt + cde_id: C4143 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4143" + term_id: C4143 + term_version: 20.05a + +tubulovillous_adenoma_nos: + common: + description: >- + An epithelial neoplasm morphologically characterized by the presence of a villous + and a tubular architectural pattern. Most often it occurs in the large intestine, + small intestine, and the stomach in which the neoplastic epithelial cells show + dysplastic features. + termDef: + term: >- + Tubulovillous Adenoma + source: NCIt + cde_id: C4143 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4143" + term_id: C4143 + term_version: 20.05a + +tumor_benign: + common: + description: >- + A neoplasm which is characterized by the absence of morphologic features associated + with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic + rate). Benign neoplasms remain confined to the original site of growth and do + not metastasize to other anatomic sites. + termDef: + term: >- + Benign Neoplasm + source: NCIt + cde_id: C3677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3677" + term_id: C3677 + term_version: 20.05a + +tumor_cells_malignant: + common: + description: >- + Cells of, or derived from, a malignant tumor. + termDef: + term: >- + Malignant Cell + source: NCIt + cde_id: C12917 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12917" + term_id: C12917 + term_version: 20.05a + +tumor_cells_nos: + common: + description: >- + Cells of, or derived from, a tumor. + termDef: + term: >- + Neoplastic Cell + source: NCIt + cde_id: C12922 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12922" + term_id: C12922 + term_version: 20.05a + +tumor_cells_uncertain_whether_benign_or_malignant: + common: + description: >- + Cells of, or derived from, a tumor. + termDef: + term: >- + Neoplastic Cell + source: NCIt + cde_id: C12922 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12922" + term_id: C12922 + term_version: 20.05a + +tumor_embolus: + common: + description: >- + A tumor embolism involves sudden blockage of an artery by a clot or by other + material from tumor fragments transported by the blood stream. + termDef: + term: >- + Tumor Embolism + source: NCIt + cde_id: C3005 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3005" + term_id: C3005 + term_version: 20.05a + +tumor_free: + common: + description: >- + There is no evidence of a tumor in the individual. + termDef: + term: >- + Tumor Free + source: NCIt + cde_id: C156848 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156848" + term_id: C156848 + term_version: 20.05a + +tumor_malignant_nos: + common: + description: >- + A tumor composed of atypical neoplastic, often pleomorphic cells that invade + other tissues. Malignant neoplasms often metastasize to distant anatomic sites + and may recur after excision. The most common malignant neoplasms are carcinomas, + Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. + termDef: + term: >- + Malignant Neoplasm + source: NCIt + cde_id: C9305 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9305" + term_id: C9305 + term_version: 20.05a + +tumor_metastatic: + common: + description: >- + A tumor that has spread from its original (primary) site of growth to another + site, close to or distant from the primary site. Metastasis is characteristic + of advanced malignancies, but in rare instances can be seen in neoplasms lacking + malignant morphology. + termDef: + term: >- + Metastatic Neoplasm + source: NCIt + cde_id: C3261 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3261" + term_id: C3261 + term_version: 20.05a + +tumor_nos: + common: + description: >- + A benign or malignant tissue growth resulting from uncontrolled cell proliferation. + Benign neoplastic cells resemble normal cells without exhibiting significant + cytologic atypia, while malignant cells exhibit overt signs such as dysplastic + features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. + Representative examples of benign neoplasms include papillomas, cystadenomas, + and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and + leukemias. + termDef: + term: >- + Neoplasm + source: NCIt + cde_id: C3262 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3262" + term_id: C3262 + term_version: 20.05a + +tumor_secondary: + common: + description: >- + A neoplasm that arises from a pre-existing lower grade lesion, or as a result + of a primary lesion that has spread to secondary sites, or due to a complication + of a cancer treatment. + termDef: + term: >- + Secondary Neoplasm + source: NCIt + cde_id: C36255 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C36255" + term_id: C36255 + term_version: 20.05a + +tumorlet_benign: + common: + description: >- + A tiny localized pulmonary nodule characterized by neuroendocrine cell proliferation. + It is usually discovered as an incidental finding during routine histologic + examination of tissue sections or during radiologic examination. + termDef: + term: >- + Tumorlet + source: NCIt + cde_id: C65162 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65162" + term_id: C65162 + term_version: 20.05a + +tunisia: + common: + description: >- + A country in northern Africa, bordering the Mediterranean Sea, between Algeria + and Libya. + termDef: + term: >- + Tunisia + source: NCIt + cde_id: C17221 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17221" + term_id: C17221 + term_version: 19.12e + +turban_tumor: + common: + description: >- + Turban Tumor + termDef: + term: >- + Turban Tumor + source: NCIt + cde_id: C43352 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43352" + term_id: C43352 + term_version: 20.05a + +turkey: + common: + description: >- + A country in southeastern Europe and southwestern Asia, between the Black Sea + and Mediterranean Sea, east of Greece and north of Syria. + termDef: + term: >- + Turkey + source: NCIt + cde_id: C17222 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17222" + term_id: C17222 + term_version: 19.12e + +turkmenistan: + common: + description: >- + A country in central Asia, bordering the Caspian Sea, between Iran and Kazakhstan. + termDef: + term: >- + Turkmenistan + source: NCIt + cde_id: C17223 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17223" + term_id: C17223 + term_version: 19.12e + +tuvalu: + common: + description: >- + A group of islands consisting of nine coral atolls in the South Pacific Ocean, + about one-half of the way from Hawaii to Australia, west of Tokelau and north + of Fiji. + termDef: + term: >- + Tuvalu + source: NCIt + cde_id: C17225 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17225" + term_id: C17225 + term_version: 19.12e + +twin_sibling: + common: + description: >- + Either of two offspring born from the same pregnancy. + termDef: + term: >- + Twin + source: NCIt + cde_id: C73427 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73427" + term_id: C73427 + term_version: 19.12e + +tx: + common: + description: >- + A primary tumor TNM finding indicating that the status of the primary tumor + cannot be assessed. + termDef: + term: >- + TX Stage Finding + source: NCIt + cde_id: C48737 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48737" + term_id: C48737 + term_version: 20.05a + +type_1: + common: + description: >- + A papillary renal cell carcinoma characterized by the presence of papillae covered + by small cells with scant amount of cytoplasm. The cells are arranged in a single + layer on the basement membrane of the papillae. + termDef: + term: >- + Type 1 Papillary Renal Cell Carcinoma + source: NCIt + cde_id: C27886 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27886" + term_id: C27886 + term_version: 20.05a + +type_2: + common: + description: >- + A papillary renal cell carcinoma characterized by the presence of papillae covered + by cells of a higher nuclear grade as compared to type 1 papillary renal cell + carcinoma. The cells have eosinophilic cytoplasm and pseudostratified nuclei. + termDef: + term: >- + Type 2 Papillary Renal Cell Carcinoma + source: NCIt + cde_id: C27887 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C27887" + term_id: C27887 + term_version: 20.05a + +tyrosine_kinase_inhibitor_tl895: + common: + description: >- + An orally bioavailable inhibitor of tyrosine kinase, with potential anti-inflammatory + and antineoplastic activities. Upon oral administration, tyrosine kinase inhibitor + TL-895 targets, binds to, and inhibits tyrosine kinase. This may result in the + inhibition of tumor angiogenesis and cell proliferation, and the inhibition + of immune-mediated inflammatory processes. Tyrosine kinases are upregulated + in many tumor cells and play important roles in tumor cell proliferation and + metastasis. In addition, they play important roles in the activation of leukocytes + and in many immune-mediated inflammatory and autoimmune conditions. + termDef: + term: >- + Tyrosine Kinase Inhibitor TL-895 + source: NCIt + cde_id: C172809 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172809" + term_id: C172809 + term_version: 20.10d + +tzone_lymphoma: + common: + description: >- + An obsolete variant of peripheral T-cell lymphoma, not otherwise specified included + in the 2008 WHO classification. These lymphomas usually have a T follicular + helper (TFH) cell phenotype and have been moved to the category of angioimmunoblastic + T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin + in the 2017 WHO update. (WHO 2017) + termDef: + term: >- + T-Zone Variant Peripheral T-Cell Lymphoma + source: NCIt + cde_id: C7204 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7204" + term_id: C7204 + term_version: 20.05a + +u2af1: + common: + description: >- + This gene is involved in the splicing of mRNA. + termDef: + term: >- + U2AF1 Gene + source: NCIt + cde_id: C101113 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101113" + term_id: C101113 + term_version: 20.10d + +ubr5: + common: + description: >- + This gene plays a role in protein ubiquitination. + termDef: + term: >- + UBR5 Gene + source: NCIt + cde_id: C111928 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111928" + term_id: C111928 + term_version: 20.10d + +uganda: + common: + description: >- + A country in eastern Africa, west of Kenya. + termDef: + term: >- + Uganda + source: NCIt + cde_id: C17228 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17228" + term_id: C17228 + term_version: 19.12e + +ukraine: + common: + description: >- + A country in eastern Europe, bordering the Black Sea, between Poland and Russia. + termDef: + term: >- + Ukraine + source: NCIt + cde_id: C17229 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17229" + term_id: C17229 + term_version: 19.12e + +ultrasound_guided_biopsy: + common: + description: >- + Biopsy of tissue using ultrasound imaging as an aid in directing a biopsy needle + into the area of interest. + termDef: + term: >- + Ultrasound-Guided Biopsy + source: NCIt + cde_id: C93022 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C93022" + term_id: C93022 + term_version: 20.05a + +uncertain_significance: + common: + description: >- + A variation in a genetic sequence whose association with disease risk is unknown. + termDef: + term: >- + Variant of Unknown Significance + source: NCIt + cde_id: C94187 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94187" + term_id: C94187 + term_version: 20.10d + +unclassified_tumor_benign: + common: + description: >- + A neoplasm which is characterized by the absence of morphologic features associated + with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic + rate). Benign neoplasms remain confined to the original site of growth and do + not metastasize to other anatomic sites. + termDef: + term: >- + Benign Neoplasm + source: NCIt + cde_id: C3677 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3677" + term_id: C3677 + term_version: 20.05a + +unclassified_tumor_borderline_malignancy: + common: + description: >- + A neoplasm which, on morphologic grounds, can not be classified with certainty + as benign or malignant. + termDef: + term: >- + Neoplasm, Uncertain Whether Benign or Malignant + source: NCIt + cde_id: C65157 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65157" + term_id: C65157 + term_version: 20.05a + +unclassified_tumor_malignant: + common: + description: >- + A tumor composed of atypical neoplastic, often pleomorphic cells that invade + other tissues. Malignant neoplasms often metastasize to distant anatomic sites + and may recur after excision. The most common malignant neoplasms are carcinomas, + Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. + termDef: + term: >- + Malignant Neoplasm + source: NCIt + cde_id: C9305 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9305" + term_id: C9305 + term_version: 20.05a + +unclassified_tumor_malignant_uncertain_whether_primary_or_metastatic: + common: + description: >- + A malignant neoplasm in which the examined tissue can not be determined with + certainty if it represents the primary site of tumor growth or tumor spread + from another anatomic site. + termDef: + term: >- + Malignant Neoplasm, Uncertain Whether Primary or Metastatic + source: NCIt + cde_id: C65153 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65153" + term_id: C65153 + term_version: 20.05a + +unclassified_tumor_uncertain_whether_benign_or_malignant: + common: + description: >- + A neoplasm which, on morphologic grounds, can not be classified with certainty + as benign or malignant. + termDef: + term: >- + Neoplasm, Uncertain Whether Benign or Malignant + source: NCIt + cde_id: C65157 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65157" + term_id: C65157 + term_version: 20.05a + +uncle: + common: + description: >- + The brother of your father or mother; the husband of your aunt. + termDef: + term: >- + Uncle + source: NCIt + cde_id: C71404 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71404" + term_id: C71404 + term_version: 19.12e + +undescended_testis: + common: + description: >- + The failure of one or both testes of a male fetus to descend from the abdomen + into the scrotum during the late part of pregnancy. If not surgically corrected + in early childhood, males may be at increased risk for testicular cancer later + in life. + termDef: + term: >- + Undescended Testes + source: NCIt + cde_id: C12326 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12326" + term_id: C12326 + term_version: 20.05a + +undifferentiated: + common: + description: >- + A neuroblastoma characterized by the absence of differentiating neuroblasts. + termDef: + term: >- + Undifferentiated Neuroblastoma + source: NCIt + cde_id: C42046 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C42046" + term_id: C42046 + term_version: 20.05a + +undifferentiated_epithelioid_sarcoma: + common: + description: >- + An undifferentiated soft tissue sarcoma characterized by the presence of a malignant + cellular infiltrate with epithelioid morphology. + termDef: + term: >- + Undifferentiated Epithelioid Sarcoma + source: NCIt + cde_id: C121802 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121802" + term_id: C121802 + term_version: 20.05a + +undifferentiated_highgrade_pleomorphic_sarcoma: + common: + description: >- + A rare, high-grade pleomorphic malignant neoplasm arising from the bone. It + usually presents with pain which may or may not be associated with swelling + in the affected area. It is characterized by the presence of spindle-shaped + cells, polygonal or epithelioid cells, multinucleated giant cells, and inflammatory + cells. The neoplastic cells exhibit nuclear pleomorphism and high mitotic activity. It + metastasizes frequently, most often in the lungs. + termDef: + term: >- + Undifferentiated High Grade Pleomorphic Sarcoma of Bone + source: NCIt + cde_id: C8563 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8563" + term_id: C8563 + term_version: 20.05a + +undifferentiated_leukaemia: + common: + description: >- + A clonal (malignant) hematopoietic disorder with an acute onset, affecting the + bone marrow and the peripheral blood. The malignant cells show minimal differentiation + and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts + (lymphoblasts). + termDef: + term: >- + Acute Leukemia + source: NCIt + cde_id: C9300 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C9300" + term_id: C9300 + term_version: 20.05a + +undifferentiated_pleomorphic_sarcoma: + common: + description: >- + An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic + malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma. + termDef: + term: >- + Undifferentiated Pleomorphic Sarcoma + source: NCIt + cde_id: C4247 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4247" + term_id: C4247 + term_version: 20.05a + +undifferentiated_round_cell_sarcoma: + common: + description: >- + An undifferentiated soft tissue sarcoma characterized by the presence of uniform + round or ovoid malignant cells with a high nuclear to cytoplasmic ratio. + termDef: + term: >- + Undifferentiated Round Cell Sarcoma + source: NCIt + cde_id: C121799 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121799" + term_id: C121799 + term_version: 20.05a + +undifferentiated_sarcoma: + common: + description: >- + An undifferentiated soft tissue sarcoma which cannot be further characterized. + termDef: + term: >- + Undifferentiated Sarcoma, Not Otherwise Specified + source: NCIt + cde_id: C121804 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121804" + term_id: C121804 + term_version: 20.05a + +undifferentiated_spindle_cell_sarcoma: + common: + description: >- + An undifferentiated soft tissue sarcoma characterized by the presence of a malignant + spindle cell infiltrate with amphophilic or palely eosinophilic cytoplasm. + termDef: + term: >- + Undifferentiated Spindle Cell Sarcoma + source: NCIt + cde_id: C121797 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C121797" + term_id: C121797 + term_version: 20.05a + +undifferentiated_uterine_sarcoma: + common: + description: >- + A rare, high grade sarcoma that arises from the endometrial stroma or myometrium + without a specific type of differentiation. It was previously also known as + high grade endometrial stromal sarcoma. In 2014, high grade endometrial stromal + sarcoma was reclassified and is currently considered a distinct and rare neoplasm. + Undifferentiated uterine sarcoma has a worse prognosis. + termDef: + term: >- + Uterine Corpus Undifferentiated Sarcoma + source: NCIt + cde_id: C8972 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C8972" + term_id: C8972 + term_version: 20.05a + +unfavorable: + common: + description: >- + Expressing something as negative, undesired or adverse. + termDef: + term: >- + Unfavorable + source: NCIt + cde_id: C102561 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102561" + term_id: C102561 + term_version: 20.05a + +unifocal: + common: + description: >- + Arising from, pertaining to, or having a single location. + termDef: + term: >- + Unifocal + source: NCIt + cde_id: C47862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C47862" + term_id: C47862 + term_version: 20.05a + +unilateral: + common: + description: >- + Being or located on or directed toward the side of the body to the east when + facing north. + termDef: + term: >- + Unilateral + source: NCIt + cde_id: C28012 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28012" + term_id: C28012 + term_version: 20.05a + +uninvolved: + common: + description: >- + Indicates the absence of tumor cells at the edge of a surgically excised specimen. + termDef: + term: >- + Negative Surgical Margin + source: NCIt + cde_id: C48621 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48621" + term_id: C48621 + term_version: 20.10d + +united_arab_emirates: + common: + description: >- + A country in the Middle East, bordering the Gulf of Oman and the Persian Gulf, + between Oman and Saudi Arabia. + termDef: + term: >- + United Arab Emirates + source: NCIt + cde_id: C17232 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17232" + term_id: C17232 + term_version: 19.12e + +united_kingdom: + common: + description: >- + A country in western Europe, comprising islands, including England, Scotland, + Wales, and the northern one-sixth of the island of Ireland, between the North + Atlantic Ocean and the North Sea, northwest of France. + termDef: + term: >- + United Kingdom + source: NCIt + cde_id: C17233 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17233" + term_id: C17233 + term_version: 19.12e + +united_states: + common: + description: >- + A country in North America, between Canada and Mexico, bordering both the North + Atlantic Ocean and the North Pacific Ocean. + termDef: + term: >- + United States + source: NCIt + cde_id: C17234 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17234" + term_id: C17234 + term_version: 19.12e + +unknown: + common: + description: >- + Not known, not observed, not recorded, or refused. + termDef: + term: >- + Unknown + source: NCIt + cde_id: C17998 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17998" + term_id: C17998 + term_version: 19.12e + +unknown_primary_site: + common: + description: >- + Referring to the fact that the original site of growth of a metastatic cancer + is unknown or uncertain. + termDef: + term: >- + Primary Site Unknown + source: NCIt + cde_id: C48322 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48322" + term_id: C48322 + term_version: 20.05a + +unknown_tumor_status: + common: + description: >- + The tumor status is unknown. + termDef: + term: >- + Unknown Tumor Status + source: NCIt + cde_id: C158709 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C158709" + term_id: C158709 + term_version: 20.05a + +unrelated: + common: + description: >- + Not connected or associated e.g. by kinship. + termDef: + term: >- + Unrelated + source: NCIt + cde_id: C25328 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25328" + term_id: C25328 + term_version: 19.12e + +unsatisfactory: + common: + description: >- + Failing to meet the quantitative or qualitative measures for the needs of a + situation. + termDef: + term: >- + Unsatisfactory + source: NCIt + cde_id: C126862 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126862" + term_id: C126862 + term_version: 20.05a + +unspecified: + common: + description: >- + Not stated explicitly or in detail. + termDef: + term: >- + Unspecified + source: NCIt + cde_id: C38046 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38046" + term_id: C38046 + term_version: 19.12e + +upifitamab: + common: + description: >- + A proprietary humanized monoclonal antibody against human sodium-dependent phosphate + transport protein 2B (SLC34A2; NaPi2b), with potential antineoplastic activity. + Upon administration of upifitamab, the antibody targets and binds to NaPi2b + expressed on tumor cells. Although the tumor cell killing effects of XMT-1535 + are not established, this binding may induce an antibody-dependent cellular + cytotoxicity (ADCC)-mediated immune response against NaPi2b-expressing tumor + cells, and/or may inhibit NaPi2b-mediated sodium and phosphate ion cotransport + activity and ion-dependent tumor cell signaling. NaPi2b, a tumor-associated + antigen (TAA), is overexpressed on a variety of tumor cells. It plays a key + role in the transport of inorganic phosphate (Pi) and the maintenance of phosphate + homeostasis. + termDef: + term: >- + Upifitamab + source: NCIt + cde_id: C147578 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C147578" + term_id: C147578 + term_version: 20.10d + +upper_gum: + common: + description: >- + Upper Gingiva + termDef: + term: >- + Upper Gingiva + source: NCIt + cde_id: C54205 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54205" + term_id: C54205 + term_version: 20.05a + +upper_limb_nos: + common: + description: >- + The region of the body that includes the arm, the forearm, and hand. + termDef: + term: >- + Upper Extremity + source: NCIt + cde_id: C12671 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12671" + term_id: C12671 + term_version: 20.05a + +upper_lobe_lung: + common: + description: >- + The lobe of the right lung that lies above the oblique and horizontal fissures + and includes the apical, posterior and anterior bronchopulmonary segments; in + the left lung, the lobe lies above the oblique fissure and contains the apicoposterior, + anterior, superior lingular and inferior lingular segments. + termDef: + term: >- + Upper Lobe of the Lung + source: NCIt + cde_id: C12285 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12285" + term_id: C12285 + term_version: 20.05a + +upper_respiratory_tract_nos: + common: + description: >- + The sinuses and those parts of the respiratory system above the trachea. It + includes the nares, nasopharynx, oropharynx, larynx, vocal cords, glottis and + upper trachea. + termDef: + term: >- + Upper Respiratory System + source: NCIt + cde_id: C33839 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33839" + term_id: C33839 + term_version: 20.05a + +upper_third_of_esophagus: + common: + description: >- + The upper one third of esophagus in which the muscle layer is composed of muscle + cells of the striated type. + termDef: + term: >- + Upper Third of the Esophagus + source: NCIt + cde_id: C12253 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12253" + term_id: C12253 + term_version: 20.05a + +upperinner_quadrant_of_breast: + common: + description: >- + The quarter of the breast which is superior and medial. + termDef: + term: >- + Upper-Inner Quadrant of the Breast + source: NCIt + cde_id: C12301 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12301" + term_id: C12301 + term_version: 20.05a + +upperouter_quadrant_of_breast: + common: + description: >- + The quarter of the breast which is superior and lateral. + termDef: + term: >- + Upper-Outer Quadrant of the Breast + source: NCIt + cde_id: C12303 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12303" + term_id: C12303 + term_version: 20.05a + +upstream_gene_variant: + common: + description: >- + Any gene mutation that occurs in the sequences upstream from a coding region + of interest. + termDef: + term: >- + 5' Flank Mutation + source: NCIt + cde_id: C63430 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C63430" + term_id: C63430 + term_version: 20.10d + +urabrelimab: + common: + description: >- + A human monoclonal antibody targeting the human cell surface antigen CD47, with + potential phagocytosis-inducing and antineoplastic activities. Upon administration, + urabrelimab selectively binds to CD47 on tumor cells and blocks the interaction + of CD47 with signal regulatory protein alpha (SIRPalpha), an inhibitory protein + expressed on macrophages. This prevents CD47/SIRPalpha-mediated signaling and + abrogates the CD47/SIRPa-mediated inhibition of phagocytosis. This induces pro-phagocytic + signaling mediated by the binding of calreticulin (CRT), which is specifically + expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related + protein (LRP), expressed on macrophages. This results in macrophage activation + and the specific phagocytosis of tumor cells. In addition, blocking CD47 signaling + activates both an anti-tumor T-lymphocyte immune response and T cell-mediated + killing of CD47-expressing tumor cells. CD47, also called integrin-associated + protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy + hematopoietic stem cells (HSCs) and overexpressed on the surface of a variety + of cancer cells. Expression of CD47, and its interaction with SIRPalpha, leads + to the inhibition of macrophage activation and protects cancer cells from phagocytosis, + which allows cancer cells to proliferate. + termDef: + term: >- + Urabrelimab + source: NCIt + cde_id: C155976 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C155976" + term_id: C155976 + term_version: 20.10d + +urachal_carcinoma: + common: + description: >- + A rare variant of carcinoma of the urachal remnant of bladder. + termDef: + term: >- + Bladder Urachal Carcinoma + source: NCIt + cde_id: C39842 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39842" + term_id: C39842 + term_version: 20.05a + +urachus: + common: + description: >- + A cord of fibrous tissue that extends from the urinary bladder to the umbilicus. + The urachus is a remnant of the fetal urinary canal. + termDef: + term: >- + Urachus + source: NCIt + cde_id: C12338 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12338" + term_id: C12338 + term_version: 20.05a + +ureter: + common: + description: >- + The thick-walled tube that carries urine from each kidney to the bladder. + termDef: + term: >- + Ureter + source: NCIt + cde_id: C12416 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12416" + term_id: C12416 + term_version: 20.05a + +ureteric_orifice: + common: + description: >- + The opening of the ureter in the bladder that is situated at the lateral angle + of the trigone. + termDef: + term: >- + Ureteric Orifice + source: NCIt + cde_id: C12337 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12337" + term_id: C12337 + term_version: 20.05a + +urethra: + common: + description: >- + The tube carrying urine from the bladder to outside of the body. + termDef: + term: >- + Urethra + source: NCIt + cde_id: C12417 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12417" + term_id: C12417 + term_version: 20.05a + +urinary_system_nos: + common: + description: >- + The organs involved in the creation and excretion of urine. + termDef: + term: >- + Urinary System + source: NCIt + cde_id: C12413 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12413" + term_id: C12413 + term_version: 20.05a + +urine: + common: + description: >- + The fluid that is excreted by the kidneys. It is stored in the bladder and discharged + through the urethra. + termDef: + term: >- + Urine + source: NCIt + cde_id: C13283 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C13283" + term_id: C13283 + term_version: 20.10d + +urothelial_carcinoma_in_situ: + common: + description: >- + A lesion in which the surface epithelium of the bladder or the renal pelvis + and ureter contains transitional cells which display malignant cytologic characteristics. There + is no evidence of stromal invasion. + termDef: + term: >- + Stage 0 Transitional Cell Carcinoma + source: NCIt + cde_id: C4116 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4116" + term_id: C4116 + term_version: 20.05a + +urothelial_carcinoma_nos: + common: + description: >- + A malignant neoplasm derived from the transitional epithelium of the urinary + tract (urinary bladder, ureter, urethra, or renal pelvis). It is frequently + papillary. + termDef: + term: >- + Urothelial Carcinoma + source: NCIt + cde_id: C4030 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4030" + term_id: C4030 + term_version: 20.05a + +urothelial_carcinoma_with_squamous_differentiation: + common: + description: >- + An invasive transitional cell carcinoma of the bladder that exhibits squamous + differentiation. + termDef: + term: >- + Infiltrating Bladder Urothelial Carcinoma with Squamous Differentiation + source: NCIt + cde_id: C39816 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39816" + term_id: C39816 + term_version: 20.05a + +urothelial_carcinoma_with_trophoblastic_differentiation: + common: + description: >- + A variant of infiltrating bladder urothelial carcinoma. It is characterized + by the presence of trophoblastic differentiation within the carcinoma. + termDef: + term: >- + Infiltrating Bladder Urothelial Carcinoma with Trophoblastic Differentiation + source: NCIt + cde_id: C39818 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C39818" + term_id: C39818 + term_version: 20.05a + +urothelial_papilloma_nos: + common: + description: >- + A rare benign condition, characterized by a papillary growth in the urinary + tract with a central fibrovascular core. The latter is lined by normal urothelium. + termDef: + term: >- + Urothelial Papilloma + source: NCIt + cde_id: C3842 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3842" + term_id: C3842 + term_version: 20.05a + +ursolic_acid: + common: + description: >- + A pentacyclic triterpenoid found in various fruits, vegetables and medicinal + herbs, with a variety of potential pharmacologic activities including anti-inflammatory, + antioxidative, antiviral, serum lipid-lowering, and antineoplastic activities. + Upon administration, ursolic acid may promote apoptosis and inhibit cancer cell + proliferation through multiple mechanisms. This may include the regulation of + mitochondrial function through various pathways including the ROCK/PTEN and + p53 pathways, the suppression of the nuclear factor-kappa B (NF-kB) pathways, + and the increase in caspase-3, caspase-8 and caspase-9 activities. + termDef: + term: >- + Ursolic Acid + source: NCIt + cde_id: C172843 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C172843" + term_id: C172843 + term_version: 20.10d + +urticaria_pigmentosa: + common: + description: >- + The most frequent form of cutaneous mastocytosis. In children, the lesions + tend to be papular, and are characterized by aggregates of elongated or spindle-shaped + mast cells which fill the papillary dermis and extend into the reticular dermis. In + adults, the lesions tend to have fewer mast cells compared to those in children. The + lesions are located most commonly on the trunk, but they can be seen on the + extremities, head and neck. (WHO, 2001) + termDef: + term: >- + Urticaria Pigmentosa/Maculopapular Cutaneous Mastocytosis + source: NCIt + cde_id: C3433 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3433" + term_id: C3433 + term_version: 20.05a + +uruguay: + common: + description: >- + A country in southern South America, bordering the South Atlantic Ocean, between + Argentina and Brazil. + termDef: + term: >- + Uruguay + source: NCIt + cde_id: C17244 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17244" + term_id: C17244 + term_version: 19.12e + +usp6: + common: + description: >- + This gene is involved in the regulation of cellular ubiquitination. It also + plays a role in promoting the recycling of endocytic vesicles to the plasma + membrane. + termDef: + term: >- + USP6 Gene + source: NCIt + cde_id: C24892 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24892" + term_id: C24892 + term_version: 20.10d + +usp8: + common: + description: >- + This gene plays a role in ubiquitin-dependent proteolysis and cell proliferation. + termDef: + term: >- + USP8 Gene + source: NCIt + cde_id: C24893 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24893" + term_id: C24893 + term_version: 20.10d + +uterine_adnexa: + common: + description: >- + The accessory structures of the uterus, including the ovaries, fallopian tubes, + broad ligament, and the ovarian and uterine ligaments. + termDef: + term: >- + Appendage of the Uterus + source: NCIt + cde_id: C12321 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12321" + term_id: C12321 + term_version: 20.05a + +uterine_cancer: + common: + description: >- + Primary or metastatic malignant neoplasm involving the uterine corpus and/or + the cervix. + termDef: + term: >- + Malignant Uterine Neoplasm + source: NCIt + cde_id: C3552 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3552" + term_id: C3552 + term_version: 19.12e + +uterus_nos: + common: + description: >- + A hollow, thick-walled, muscular organ located within the pelvic cavity of a + woman. Within the uterus the fertilized egg implants and the fetus develops + during pregnancy. + termDef: + term: >- + Uterus + source: NCIt + cde_id: C12405 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12405" + term_id: C12405 + term_version: 20.05a + +uvula: + common: + description: >- + The fleshy lobe that hangs at the back of the soft palate. + termDef: + term: >- + Uvula + source: NCIt + cde_id: C12232 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12232" + term_id: C12232 + term_version: 20.05a + +uzansertib: + common: + description: >- + An orally available, small molecule and selective ATP-competitive pan-inhibitor + of proviral integration sites for Moloney murine leukemia virus (PIM) kinases, + with potential antineoplastic activity. Upon oral administration, uzansertib + binds to and inhibits the activities of the three PIM isoforms, PIM1, PIM2 and + PIM3. This prevents phosphorylation of their downstream targets and inhibits + proliferation in cells that overexpress PIMs. PIMs, constitutively active proto-oncogenic + serine/threonine kinases upregulated in various types of cancers, play key roles + in tumor cell proliferation and survival. + termDef: + term: >- + Uzansertib + source: NCIt + cde_id: C124226 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C124226" + term_id: C124226 + term_version: 20.10d + +uzbekistan: + common: + description: >- + A country in central Asia, north of Afghanistan, between Turkmenistan and Kazakhstan. + termDef: + term: >- + Uzbekistan + source: NCIt + cde_id: C17246 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17246" + term_id: C17246 + term_version: 19.12e + +vagina_nos: + common: + description: >- + The female genital canal, extending from the uterus to the vulva. + termDef: + term: >- + Vagina + source: NCIt + cde_id: C12407 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12407" + term_id: C12407 + term_version: 20.05a + +vaginal_intraepithelial_neoplasia_grade_iii: + common: + description: >- + Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph + node metastasis. M0: No distant metastasis. (AJCC 6th ed.) + termDef: + term: >- + Stage 0 Vaginal Cancer AJCC v6 + source: NCIt + cde_id: C7855 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7855" + term_id: C7855 + term_version: 20.05a + +vain_iii: + common: + description: >- + Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (preinvasive carcinoma). + N0: No regional lymph node metastasis. M0: No distant metastasis. FIGO no + longer includes stage 0. (AJCC 7th ed.) + termDef: + term: >- + Stage 0 Vaginal Cancer AJCC v7 + source: NCIt + cde_id: C89476 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C89476" + term_id: C89476 + term_version: 20.05a + +valecobulin: + common: + description: >- + A benzophenone derivative and water soluble valine prodrug of the tubulin binding + agent S516, with potential tubulin-inhibiting, vascular-disrupting and antineoplastic + activity. Upon administration, valecobulin is converted into its active metabolite + S-516 that binds to tubulin and prevents its polymerization in tumor blood vessel + endothelial cells and tumor cells. This blocks the formation of the mitotic + spindle and leads to cell cycle arrest at the G2/M phase. As a result, this + agent disrupts the tumor vasculature and tumor blood flow, deprives tumor cells + of nutrients and induces tumor cell apoptosis. In addition, this agent has a + direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. + termDef: + term: >- + Valecobulin + source: NCIt + cde_id: C101264 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101264" + term_id: C101264 + term_version: 20.10d + +valemetostat: + common: + description: >- + An orally available selective inhibitor of the histone lysine methyltransferases + enhancer of zeste homolog 1 (EZH1) and 2 (EZH2), with potential antineoplastic + activity. Upon oral administration, valemetostat selectively inhibits the activity + of both wild-type and mutated forms of EZH1 and EZH2. Inhibition of EZH1/2 specifically + prevents the methylation of lysine 27 on histone H3 (H3K27). This decrease in + histone methylation alters gene expression patterns associated with cancer pathways, + enhances transcription of certain target genes, and results in decreased proliferation + of EZH1/2-expressing cancer cells. EZH1/2, histone lysine methyltransferase + (HMT) class enzymes and catalytic subunits of the polycomb repressive complex + 2 (PRC2), are overexpressed or mutated in a variety of cancer cells and play + key roles in tumor cell proliferation, progression, stem cell self-renewal and + migration. + termDef: + term: >- + Valemetostat + source: NCIt + cde_id: C127114 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127114" + term_id: C127114 + term_version: 20.10d + +vallecula: + common: + description: >- + A groove between the base of the tongue and the epiglottis. + termDef: + term: >- + Vallecula + source: NCIt + cde_id: C12237 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12237" + term_id: C12237 + term_version: 20.05a + +vanuatu: + common: + description: >- + A group of islands in the South Pacific Ocean, about three-quarters of the way + from Hawaii to Australia. + termDef: + term: >- + Vanuatu + source: NCIt + cde_id: C17247 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17247" + term_id: C17247 + term_version: 19.12e + +vascular_leiomyoma: + common: + description: >- + A benign, slow-growing neoplasm that arises from the dermis or subcutaneous + tissue. It is characterized by the presence of well-differentiated smooth muscle + cells which are arranged around numerous vessels. + termDef: + term: >- + Angioleiomyoma + source: NCIt + cde_id: C3747 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3747" + term_id: C3747 + term_version: 20.05a + +vav1: + common: + description: >- + This gene plays a role in signal transduction. It is involved in the development + and activation of both B cells and T cells. + termDef: + term: >- + VAV1 Gene + source: NCIt + cde_id: C18365 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18365" + term_id: C18365 + term_version: 20.10d + +venezuela: + common: + description: >- + A country in northern South America, bordering the Caribbean Sea and the North + Atlantic Ocean, between Colombia and Guyana. + termDef: + term: >- + Venezuela + source: NCIt + cde_id: C17250 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17250" + term_id: C17250 + term_version: 19.12e + +venous_hemangioma: + common: + description: >- + A hemangioma composed of veins. + termDef: + term: >- + Venous Hemangioma + source: NCIt + cde_id: C4296 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4296" + term_id: C4296 + term_version: 20.05a + +ventricle_nos: + common: + description: >- + The four connected cavities (hollow spaces) centrally located within the brain + that connect posteriorly with the central canal of the spinal cord. + termDef: + term: >- + Brain Ventricle + source: NCIt + cde_id: C12356 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12356" + term_id: C12356 + term_version: 20.05a + +verrucous_carcinoma_nos: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary growth + pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most + commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, + esophagus, anus, vagina, vulva, and the plantar region of the foot. + termDef: + term: >- + Verrucous Carcinoma + source: NCIt + cde_id: C3781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3781" + term_id: C3781 + term_version: 20.05a + +verrucous_epidermoid_carcinoma: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary growth + pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most + commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, + esophagus, anus, vagina, vulva, and the plantar region of the foot. + termDef: + term: >- + Verrucous Carcinoma + source: NCIt + cde_id: C3781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3781" + term_id: C3781 + term_version: 20.05a + +verrucous_keratotic_hemangioma: + common: + description: >- + A skin hemangioma characterized by the presence of epidermal hyperplasia. + termDef: + term: >- + Verrucous Hemangioma + source: NCIt + cde_id: C4299 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4299" + term_id: C4299 + term_version: 20.05a + +verrucous_papilloma: + common: + description: >- + A benign epithelial neoplasm characterized by a papillary growth pattern, lack + of significant cytologic atypia, and a wart-like appearance. + termDef: + term: >- + Verrucous Papilloma + source: NCIt + cde_id: C4101 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4101" + term_id: C4101 + term_version: 20.05a + +verrucous_squamous_cell_carcinoma: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary growth + pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most + commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, + esophagus, anus, vagina, vulva, and the plantar region of the foot. + termDef: + term: >- + Verrucous Carcinoma + source: NCIt + cde_id: C3781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3781" + term_id: C3781 + term_version: 20.05a + +vertebral_canal: + common: + description: >- + The space formed by the series of vertebral foramina that courses the length + of the vertebral column, and which houses the spinal cord and meninges. + termDef: + term: >- + Vertebral Canal + source: NCIt + cde_id: C33869 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33869" + term_id: C33869 + term_version: 20.10d + +vertebral_column: + common: + description: >- + A series of bones, muscles, tendons, and other tissues reaching from the base + of the skull to the tailbone. The vertebral column forms the axis of the skeleton + and encloses as well as protects the spinal cord and the fluid surrounding the + spinal cord. + termDef: + term: >- + Vertebral Column + source: NCIt + cde_id: C12998 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12998" + term_id: C12998 + term_version: 20.05a + +vesencumab: + common: + description: >- + A human IgG1 monoclonal antibody directed against neuropilin-1 (NRP1), with + potential antiangiogenic and antineoplastic activities. Upon intravenous administration, + vesencumab specifically targets and binds to NRP1; the antibody-NRP1 complex + prevents the subsequent coupling of NRP1 to VEGFR2, thereby potentially inhibiting + VEGF-mediated signaling and potentially preventing angiogenesis. In combination + with other anti-VEGF therapies, vesencumab may enhance their anti-angiogenic + effect. NRP1 is a membrane-bound co-receptor normally expressed by endothelial + cells and overexpressed by certain tumor cells, and plays a role in angiogenesis, + cell survival, migration, and invasion. + termDef: + term: >- + Vesencumab + source: NCIt + cde_id: C91728 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C91728" + term_id: C91728 + term_version: 20.10d + +vestibule_of_mouth: + common: + description: >- + The area inside the mouth between the cheek or lips, and the teeth. + termDef: + term: >- + Vestibule of Mouth + source: NCIt + cde_id: C165195 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165195" + term_id: C165195 + term_version: 20.05a + +vgprvery_good_partial_response: + common: + description: >- + Partial response with additional serum and urine M-protein reduction, but not + meeting complete response. + termDef: + term: >- + Very Good Partial Response + source: NCIt + cde_id: C123618 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123618" + term_id: C123618 + term_version: 20.05a + +vhl: + common: + description: >- + This gene is involved in transcriptional repression and protein degradation. + termDef: + term: >- + VHL Gene + source: NCIt + cde_id: C18261 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18261" + term_id: C18261 + term_version: 20.10d + +vibecotamab: + common: + description: >- + An anti-CD123/anti-CD3 bispecific monoclonal antibody, in which most of the + naturally-occurring Fc domain is maintained, with potential immunostimulatory + and antineoplastic activities. Vibecotamab possesses two antigen-recognition + and binding sites, one for the CD3 complex, a group of T-cell surface glycoproteins + that complex with the T-cell receptor (TCR), and one for CD123, a tumor-associated + antigen (TAA) overexpressed on the surface of certain tumor cells. Upon administration + of vibecotamab, this bispecific antibody simultaneously binds to both CD3-expressing + T-cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing + tumor cells and cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated + cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3 receptor + alpha chain, is overexpressed in a variety of hematological malignancies; its + expression is low or absent in normal hematopoietic progenitors and stem cells. + The Fc domain on the antibody prolongs the half-life of the bispecific antibody + and enhances T-cell mediated tumor cell killing through its binding to the Fc + receptors. + termDef: + term: >- + Vibecotamab + source: NCIt + cde_id: C127120 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127120" + term_id: C127120 + term_version: 20.10d + +vibostolimab: + common: + description: >- + An antagonistic agent targeting the co-inhibitory molecule and immune checkpoint + inhibitor T-cell immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory + motif (ITIM) domains (TIGIT; T-cell immunoreceptor with Ig and ITIM domains; + T-cell immunoglobulin and ITIM domain), with potential immune checkpoint inhibitory + and antineoplastic activities. Upon administration, vibostolimab targets and + binds to TIGIT expressed on various immune cells, particularly on tumor-infiltrating + T-lymphocytes (TILs) and natural killer (NK) cells, thereby preventing the interaction + of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2; PVRL2) + and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5), which are + expressed on T-cells, NK cells and certain cancer cells. This enhances the interaction + of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; + DNAM-1), which is expressed on immune cells, such as NK cells and CD8+ T-cells, + and activates CD226-mediated signaling. This activates the immune system to + exert a T-cell-mediated immune response against cancer cells. TIGIT, a member + of the Ig super family and an immune inhibitory receptor, is overexpressed on + tumor antigen-specific CD8+ T-cells and CD8+ TILs and plays a key role in the + suppression of T-cell proliferation and activation; it is involved in tumor + cell immune evasion, and the inhibition of antiviral immune responses. + termDef: + term: >- + Vibostolimab + source: NCIt + cde_id: C140041 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C140041" + term_id: C140041 + term_version: 20.10d + +vietnam: + common: + description: >- + A country in southeastern Asia, bordering the Gulf of Thailand, Gulf of Tonkin, + and South China Sea, alongside China, Laos, and Cambodia. + termDef: + term: >- + Vietnam + source: NCIt + cde_id: C17252 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17252" + term_id: C17252 + term_version: 19.12e + +villoglandular_adenoma: + common: + description: >- + An epithelial neoplasm morphologically characterized by the presence of a villous + and a tubular architectural pattern. Most often it occurs in the large intestine, + small intestine, and the stomach in which the neoplastic epithelial cells show + dysplastic features. + termDef: + term: >- + Tubulovillous Adenoma + source: NCIt + cde_id: C4143 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4143" + term_id: C4143 + term_version: 20.05a + +villoglandular_carcinoma: + common: + description: >- + A cervical adenocarcinoma characterized by the presence of a prominent villoglandular + pattern. + termDef: + term: >- + Cervical Villoglandular Adenocarcinoma + source: NCIt + cde_id: C40208 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C40208" + term_id: C40208 + term_version: 20.05a + +villous_adenocarcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of a villous architectural pattern. + It may arise from a villous adenoma. + termDef: + term: >- + Villous Adenocarcinoma + source: NCIt + cde_id: C4142 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4142" + term_id: C4142 + term_version: 20.05a + +villous_adenoma_nos: + common: + description: >- + An epithelial neoplasm morphologically characterized by the presence of a villous + architectural pattern. Most often it occurs in the large intestine, small intestine, + and the stomach in which the neoplastic epithelial cells show dysplastic features. + It may also arise in the urinary bladder, urethra, and vagina. + termDef: + term: >- + Villous Adenoma + source: NCIt + cde_id: C7399 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7399" + term_id: C7399 + term_version: 20.05a + +vin_iii: + common: + description: >- + Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (preinvasive carcinoma. + N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th + ed.) + termDef: + term: >- + Stage 0 Vulvar Cancer AJCC v6 + source: NCIt + cde_id: C4522 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4522" + term_id: C4522 + term_version: 20.05a + +vipoma_malignant: + common: + description: >- + An aggressive neuroendocrine tumor located in the pancreas or small intestine. + It is composed of cells containing vasoactive intestinal peptide. It is associated + with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria. It displays + vascular invasion and metastasizes to other anatomic sites. + termDef: + term: >- + Malignant Vipoma + source: NCIt + cde_id: C65189 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C65189" + term_id: C65189 + term_version: 20.05a + +vipoma_nos: + common: + description: >- + An often clinically aggressive neuroendocrine tumor located in the pancreas + or small intestine. It is composed of cells containing vasoactive intestinal + peptide. It may cause intractable diarrhea and metabolic disturbances. + termDef: + term: >- + VIP-Producing Neuroendocrine Tumor + source: NCIt + cde_id: C26749 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26749" + term_id: C26749 + term_version: 20.05a + +virgin_islands_british: + common: + description: >- + A group of islands between the Caribbean Sea and the North Atlantic Ocean, east + of the US Virgin Islands. + termDef: + term: >- + Virgin Islands, British + source: NCIt + cde_id: C17653 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17653" + term_id: C17653 + term_version: 19.12e + +virgin_islands_us: + common: + description: >- + A group of islands between the Caribbean Sea and the North Atlantic Ocean, east + of Puerto Rico and west of the British Virgin Islands. + termDef: + term: >- + Virgin Islands, U.S. + source: NCIt + cde_id: C17255 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17255" + term_id: C17255 + term_version: 19.12e + +visual_changes: + common: + description: >- + An alteration in the visual system of an individual. + termDef: + term: >- + Visual Change + source: NCIt + cde_id: C157424 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C157424" + term_id: C157424 + term_version: 20.05a + +volcanic_smoke: + common: + description: >- + Environmental exposure to airborne gases and particulates produced by a volcanic + event. + termDef: + term: >- + Volcanic Smoke Exposure + source: NCIt + cde_id: C164100 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164100" + term_id: C164100 + term_version: 19.12e + +von_recklinghausen_disease: + common: + description: >- + The most common type of neurofibromatosis. It is characterized clinically by + cutaneous and subcutaneous tumors with patches of hyperpigmentation. The hyperpigmented + skin areas, are present from birth and found anywhere on the body surface. They + can vary markedly in size and color. The dark brown areas are called cafe-au-lait + spots. The multiple cutaneous and subcutaneous tumors are nerve sheath tumors, + called neurofibromas. They can develop anywhere along the peripheral nerve + fibers. Neurofibromas can become quite large, causing a major disfigurement, + eroding bone, and compressing various peripheral nerve structures. Type 1 neurofibromatosis + has dominant inheritance, with a gene locus on the proximal long arm of chromosome + 17. + termDef: + term: >- + Neurofibromatosis Type 1 + source: NCIt + cde_id: C3273 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3273" + term_id: C3273 + term_version: 20.05a + +vorasidenib: + common: + description: >- + An orally available inhibitor of mutated forms of both isocitrate dehydrogenase + type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate + dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic + activity. Upon administration, vorasidenib specifically inhibits mutant forms + of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate + (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling + and leads to both an induction of cellular differentiation and an inhibition + of cellular proliferation in tumor cells expressing IDH mutations. In addition, + vorasidenib is able to penetrate the blood-brain barrier (BBB). IDH1 and 2, + metabolic enzymes that catalyze the conversion of isocitrate into a-KG, play + key roles in energy production and are mutated in a variety of cancer cell types. + In addition, mutant forms of IDH1 and 2 catalyze the formation of 2HG and drive + cancer growth by blocking cellular differentiation and inducing cellular proliferation. + termDef: + term: >- + Vorasidenib + source: NCIt + cde_id: C152914 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C152914" + term_id: C152914 + term_version: 20.10d + +vosilasarm: + common: + description: >- + An orally bioavailable, non-steroidal selective androgen receptor modulator + (SARM), with potential tissue-selective androgenic/anti-androgenic activities. + Upon oral administration, vosilasarm acts as an agonist in select tissues, such + as skeletal muscle and bone, where it binds to and activates androgen receptors + (ARs). In the prostate and breasts, RAD140 acts as an antagonist and blocks + AR activation and AR-mediated cellular proliferation. Therefore, this agent + may improve bone formation and muscle mass and strength, and may inhibit both + the growth of the prostate in males and AR-dependent breast cancer cell proliferation. + Compared to anabolic agents, SARMs have reduced androgenic properties. + termDef: + term: >- + Vosilasarm + source: NCIt + cde_id: C137950 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C137950" + term_id: C137950 + term_version: 20.10d + +vti1a: + common: + description: >- + This gene is involved in vesicular transport. + termDef: + term: >- + VTI1A Gene + source: NCIt + cde_id: C99462 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99462" + term_id: C99462 + term_version: 20.10d + +vulinacimab: + common: + description: >- + A fully human monoclonal antibody directed against human vascular endothelial + growth factor receptor 2 (VEGFR-2) with potential anti-angiogenesis and antineoplastic + activities. Upon administration, vulinacimab specifically binds to and inhibits + VEGFR-2, which may inhibit tumor angiogenesis and tumor cell proliferation. + VEGFR-2, a tyrosine-protein kinase that plays an essential role in angiogenesis + and the proliferation, survival, migration and differentiation of endothelial + cells, is overexpressed in certain tumor types. + termDef: + term: >- + Vulinacimab + source: NCIt + cde_id: C156172 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156172" + term_id: C156172 + term_version: 20.10d + +vulva_nos: + common: + description: >- + The external, visible part of the female genitalia surrounding the urethral + and vaginal opening. The vulva includes the clitoris and inner as well as outer + labia. + termDef: + term: >- + Vulva + source: NCIt + cde_id: C12408 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12408" + term_id: C12408 + term_version: 20.05a + +vulvar_intraepithelial_neoplasia_grade_iii: + common: + description: >- + Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (preinvasive carcinoma. + N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th + ed.) + termDef: + term: >- + Stage 0 Vulvar Cancer AJCC v6 + source: NCIt + cde_id: C4522 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4522" + term_id: C4522 + term_version: 20.05a + +waldenstrom_macroglobulinemia: + common: + description: >- + Lymphoplasmacytic lymphoma associated with bone marrow involvement and IgM monoclonal + gammopathy. + termDef: + term: >- + Waldenstrom Macroglobulinemia + source: NCIt + cde_id: C80307 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80307" + term_id: C80307 + term_version: 20.05a + +waldeyer_ring: + common: + description: >- + The ring of lymphoid tissue located in the pharynx, consisting of the pharyngeal, + tubal, palatine, and lingual tonsils. + termDef: + term: >- + Waldeyer's Tonsillar Ring + source: NCIt + cde_id: C73468 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73468" + term_id: C73468 + term_version: 20.05a + +wallis_and_futuna: + common: + description: >- + A group of islands in the South Pacific Ocean, about two-thirds of the way from + Hawaii to New Zealand, northeast of Fiji and west of American Samoa. + termDef: + term: >- + Wallis and Futuna + source: NCIt + cde_id: C17259 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17259" + term_id: C17259 + term_version: 19.12e + +ward: + common: + description: >- + A person who is under the protection or in the custody of another. + termDef: + term: >- + Ward + source: NCIt + cde_id: C71413 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71413" + term_id: C71413 + term_version: 19.12e + +warthin_tumor: + common: + description: >- + An adenoma characterized by an oncocytic, often papillary, epithelial component, + dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid + gland, and is the second most common benign parotid salivary gland tumor. A + strong association with smoking has been reported. It typically presents as + a painless swelling in the lower portion of the parotid gland. + termDef: + term: >- + Warthin Tumor + source: NCIt + cde_id: C2854 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2854" + term_id: C2854 + term_version: 20.05a + +warty_carcinoma: + common: + description: >- + A well differentiated squamous cell carcinoma characterized by a papillary growth + pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most + commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, + esophagus, anus, vagina, vulva, and the plantar region of the foot. + termDef: + term: >- + Verrucous Carcinoma + source: NCIt + cde_id: C3781 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3781" + term_id: C3781 + term_version: 20.05a + +was: + common: + description: >- + This gene is involved in signal transduction and plays a role in cell communication + and organization. + termDef: + term: >- + WAS Gene + source: NCIt + cde_id: C43236 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43236" + term_id: C43236 + term_version: 20.10d + +waste_burning_smoke: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when trash or waste is burned. + termDef: + term: >- + Burning Waste Smoke Exposure + source: NCIt + cde_id: C164101 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164101" + term_id: C164101 + term_version: 19.12e + +waterclear_cell_adenocarcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of malignant epithelial cells + with clear, often vacuolated or foamy cytoplasm. + termDef: + term: >- + Water-Clear Cell Adenocarcinoma + source: NCIt + cde_id: C4156 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4156" + term_id: C4156 + term_version: 20.05a + +waterclear_cell_adenoma: + common: + description: >- + A rare parathyroid gland adenoma composed of neoplastic cells with abundant + cytoplasm. The cytoplasm of the neoplastic cells is usually not entirely clear, + and is often variably vacuolated, foamy, and granular. + termDef: + term: >- + Parathyroid Gland Water-Clear Cell Adenoma + source: NCIt + cde_id: C4155 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4155" + term_id: C4155 + term_version: 20.05a + +waterclear_cell_carcinoma: + common: + description: >- + An adenocarcinoma characterized by the presence of malignant epithelial cells + with clear, often vacuolated or foamy cytoplasm. + termDef: + term: >- + Water-Clear Cell Adenocarcinoma + source: NCIt + cde_id: C4156 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4156" + term_id: C4156 + term_version: 20.05a + +wdcp: + common: + description: >- + This gene plays a role in binding to tyrosine-protein kinase HCK. + termDef: + term: >- + WDCP Gene + source: NCIt + cde_id: C101428 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101428" + term_id: C101428 + term_version: 20.10d + +wee1_inhibitor_znc3: + common: + description: >- + An inhibitor of the tyrosine kinase Wee1 (Wee1-like protein kinase; Wee1A kinase; + WEE1hu) with potential antineoplastic sensitizing activity. Although the exact + mechanism of action by which this agent inhibits Wee1 has yet to be disclosed, + upon administration of ZN-c3, this agent targets and inhibits Wee1. Inhibition + of Wee1 promotes both premature mitosis and a prolonged mitotic arrest leading + to cell death in susceptible tumor cells, such as p53-deficient or mutated human + cancers that lack the G1 checkpoint, upon treatment with DNA-damaging chemotherapeutic + agents. Unlike normal cells, most p53-deficient or mutated human cancers lack + the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these + cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of + the G2 checkpoint may therefore make p53-deficient tumor cells more vulnerable + to antineoplastic agents and enhance their cytotoxic effect. Overexpression + of Wee1 occurs in several cancer types and high expression of Wee1 is associated + with poor outcomes. Wee1 phosphorylates Cdc2 in the Cdc2/cyclin B (CDK1/cyclin + B) complex which blocks progression from G2 into mitosis; it negatively regulates + the G2 checkpoint by disallowing entry into mitosis in response to DNA damage. + termDef: + term: >- + Wee1 Inhibitor ZN-c3 + source: NCIt + cde_id: C167064 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C167064" + term_id: C167064 + term_version: 20.10d + +wee1_kinase_inhibitor_debio_0123: + common: + description: >- + An orally bioavailable inhibitor of the human tyrosine kinase Wee1 (Wee1-like + protein kinase; Wee1A kinase; WEE1hu), with potential antineoplastic sensitizing + activity. Upon oral administration of Debio 0123, this agent targets, binds + to and inhibits Wee1. Inhibition of Wee1 inhibits Cdk1 (Cdc2) phosphorylation, + promotes both premature mitosis and a prolonged mitotic arrest, which results + in the accumulation of unrepaired DNA damage. This leads to apoptosis in susceptible + tumor cells, such as p53-deficient or mutated human cancers that lack the G1 + checkpoint, especially in combination with DNA-damaging chemotherapeutic agents. + Unlike normal cells, most p53-deficient or mutated human cancers lack the G1 + checkpoint as p53 is the key regulator of the G1 checkpoint and these cells + rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the + G2 checkpoint may therefore make p53-deficient tumor cells more vulnerable to + antineoplastic agents and enhance their cytotoxic effect. Overexpression of + Wee1 occurs in several cancer types and high expression of Wee1 is associated + with poor outcomes. Wee1 phosphorylates Cdc2 in the Cdc2/cyclin B (CDK1/cyclin + B) complex which blocks progression from G2 into mitosis. The Wee1 tyrosine + kinase is activated upon DNA damage and regulates the G2-M and S cell cycle + checkpoints. + termDef: + term: >- + Wee1 Kinase Inhibitor Debio 0123 + source: NCIt + cde_id: C173426 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C173426" + term_id: C173426 + term_version: 20.10d + +well_differentiated_liposarcoma_of_superficial_soft_tissue: + common: + description: >- + An intermediate, locally aggressive lipomatous neoplasm. Microscopically, the + adipose tissue contains large and pleomorphic lipoblasts, and is dissected by + fibrous septa containing spindle cells. It requires a wide local excision, + may recur locally, but never metastasizes. + termDef: + term: >- + Atypical Lipomatous Tumor + source: NCIt + cde_id: C6505 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C6505" + term_id: C6505 + term_version: 20.05a + +well_differentiated_thymic_carcinoma: + common: + description: >- + Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial + thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated + carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka + stage II or stage III tumors. It is almost always invasive, it recurs frequently, + and metastasizes in approximately 20% of the cases. + termDef: + term: >- + Thymoma Type B3 + source: NCIt + cde_id: C7997 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C7997" + term_id: C7997 + term_version: 20.05a + +western_sahara: + common: + description: >- + A country in northern Africa, bordering the North Atlantic Ocean, between Mauritania + and Morocco. + termDef: + term: >- + Western Sahara + source: NCIt + cde_id: C20113 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20113" + term_id: C20113 + term_version: 19.12e + +wgs: + common: + description: >- + A procedure that can determine the DNA sequence for nearly the entire genome + of an individual. + termDef: + term: >- + Whole Genome Sequencing + source: NCIt + cde_id: C101294 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101294" + term_id: C101294 + term_version: 20.10d + +white: + demographic: + race: + description: >- + A person having origins in any of the original peoples of Europe, the Middle + East, or North Africa. (OMB) + termDef: + term: >- + White + source: NCIt + cde_id: C41261 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C41261" + term_id: C41261 + term_version: 19.12e + +white_matter: + common: + description: >- + The nerve tissue forming the bulk of the deep parts of the brain and the superficial + parts of the spinal cord. It is composed of nerve cell processes, i.e. extensions + (axons), which connect various grey matter areas of the brain to each other + and carry nerve impulses to and from the nerve cell bodies within the central + nervous system (neurons). Cerebral and spinal white matter does not contain + dendrites. White matter is distinguished in that it is composed of axonal nerve + fibers covered by a myelin sheath. + termDef: + term: >- + White Matter + source: NCIt + cde_id: C33892 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33892" + term_id: C33892 + term_version: 20.05a + +wif1: + common: + description: >- + This gene plays a role in Wnt protein-dependent signaling. + termDef: + term: >- + WIF1 Gene + source: NCIt + cde_id: C97867 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97867" + term_id: C97867 + term_version: 20.10d + +wife: + common: + description: >- + A female partner in marriage. + termDef: + term: >- + Wife + source: NCIt + cde_id: C71587 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71587" + term_id: C71587 + term_version: 19.12e + +wilms_tumor: + common: + description: >- + An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, + and blastema components. The vast majority of cases arise from the kidney. A + small number of cases with morphologic features resembling Wilms tumor of the + kidney have been reported arising from the ovary and the cervix. + termDef: + term: >- + Wilms Tumor + source: NCIt + cde_id: C3267 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3267" + term_id: C3267 + term_version: 19.12e + +with_tumor: + common: + description: >- + There is evidence of a tumor in an individual. + termDef: + term: >- + With Tumor + source: NCIt + cde_id: C156849 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156849" + term_id: C156849 + term_version: 20.05a + +within_5_minutes: + common: + description: >- + An indication that less than 5 minutes passes between waking and smoking the + first cigarette of the day. + termDef: + term: >- + Time Between Waking and First Smoke - Within 5 Minutes + source: NCIt + cde_id: C164121 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164121" + term_id: C164121 + term_version: 19.12e + +wnk2: + common: + description: >- + This gene plays a role in electrolyte homeostasis, cell signaling, cell survival, + and cellular proliferation. + termDef: + term: >- + WNK2 Gene + source: NCIt + cde_id: C143106 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143106" + term_id: C143106 + term_version: 20.10d + +wntactivated: + common: + description: >- + A molecular subtype of medulloblastoma associated with activation of the WNT + pathway. TP53 mutations may be present or absent. WNT pathway activation in + medulloblastomas is associated with good outcome. + termDef: + term: >- + Medulloblastoma, WNT-Activated + source: NCIt + cde_id: C129440 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C129440" + term_id: C129440 + term_version: 20.05a + +wolffian_duct_adenoma: + common: + description: >- + A benign epithelial neoplasm of the female reproductive system arising from + mesonephric remnants. + termDef: + term: >- + Benign Mesonephroma + source: NCIt + cde_id: C4294 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4294" + term_id: C4294 + term_version: 20.05a + +wolffian_duct_carcinoma: + common: + description: >- + An adenocarcinoma of the cervix or the vagina arising from mesonephric remnants. + termDef: + term: >- + Mesonephric Adenocarcinoma + source: NCIt + cde_id: C4072 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4072" + term_id: C4072 + term_version: 20.05a + +wolffian_duct_tumor: + common: + description: >- + An epithelial neoplasm of the female reproductive system arising from mesonephric + remnants. + termDef: + term: >- + Mesonephric Neoplasm + source: NCIt + cde_id: C4295 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C4295" + term_id: C4295 + term_version: 20.05a + +wood_burning_smoke_factory: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when wood is burned in a factory setting. + termDef: + term: >- + Wood-Burning Factory Smoke Exposure + source: NCIt + cde_id: C164102 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164102" + term_id: C164102 + term_version: 19.12e + +wood_burning_smoke_nos: + common: + description: >- + Environmental or occupational exposure to airborne gases and particulates produced + when wood is subjected to combustion. + termDef: + term: >- + Burning Wood Smoke Exposure + source: NCIt + cde_id: C164065 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164065" + term_id: C164065 + term_version: 19.12e + +workrelated_smoke_artificial_smoke_machines: + common: + description: >- + Occupational exposure to airborne gases and particulates during the operation + of a machine that produces artificial smoke. + termDef: + term: >- + Occupational Artificial Smoke Machine Smoke Exposure + source: NCIt + cde_id: C164104 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164104" + term_id: C164104 + term_version: 19.12e + +workrelated_smoke_fire_fighting: + common: + description: >- + Occupational exposure to airborne gases and particulates while preventing, controlling + or extinguishing fires. + termDef: + term: >- + Occupational Fire Fighting Smoke Exposure + source: NCIt + cde_id: C164105 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164105" + term_id: C164105 + term_version: 19.12e + +workrelated_smoke_foundry: + common: + description: >- + Occupational exposure to airborne gases and particulates during the operation + of a foundry. + termDef: + term: >- + Occupational Foundry Smoke Exposure + source: NCIt + cde_id: C164106 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164106" + term_id: C164106 + term_version: 19.12e + +workrelated_smoke_generators: + common: + description: >- + Occupational exposure to airborne gases and particulates during the operation + of a power generator. + termDef: + term: >- + Occupational Generator Smoke Exposure + source: NCIt + cde_id: C164107 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164107" + term_id: C164107 + term_version: 19.12e + +workrelated_smoke_military: + common: + description: >- + Occupational exposure to airborne gases and particulates during a military posting + or deployment. + termDef: + term: >- + Occupational Military Smoke Exposure + source: NCIt + cde_id: C164115 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164115" + term_id: C164115 + term_version: 19.12e + +workrelated_smoke_nos: + common: + description: >- + Occupational exposure to airborne gases and particulates produced when materials + undergo combustion or thermal decomposition. + termDef: + term: >- + Work-Related Smoke Exposure + source: NCIt + cde_id: C164103 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164103" + term_id: C164103 + term_version: 19.12e + +workrelated_smoke_paint_baking: + common: + description: >- + Occupational exposure to airborne gases and particulates during the operation + of a paint oven. + termDef: + term: >- + Occupational Paint Baking Smoke Exposure + source: NCIt + cde_id: C164116 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164116" + term_id: C164116 + term_version: 19.12e + +workrelated_smoke_plastics_factory: + common: + description: >- + Occupational exposure to airborne gases and particulates during the manufacturing + of plastics. + termDef: + term: >- + Occupational Plastics Factory Smoke Exposure + source: NCIt + cde_id: C164118 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164118" + term_id: C164118 + term_version: 19.12e + +workrelated_smoke_plumbing: + common: + description: >- + Occupational exposure to airborne gases and particulates during the installation + of plumbing pipes and fixtures. + termDef: + term: >- + Occupational Plumbing Smoke Exposure + source: NCIt + cde_id: C164119 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164119" + term_id: C164119 + term_version: 19.12e + +workrelated_smoke_solderingwelding: + common: + description: >- + Occupational exposure to airborne gases and particulates during the operation + of a soldering iron or welding machine. + termDef: + term: >- + Occupational Soldering/Welding Smoke Exposure + source: NCIt + cde_id: C164120 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C164120" + term_id: C164120 + term_version: 19.12e + +wrn: + common: + description: >- + This gene is involved in DNA repair and the unwinding of DNA. + termDef: + term: >- + WRN Gene + source: NCIt + cde_id: C20070 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20070" + term_id: C20070 + term_version: 20.10d + +wt1: + common: + description: >- + This gene plays a role in regulation of transcription. It is involved in the + control of both cell differentiation and proliferation. + termDef: + term: >- + WT1 Gene + source: NCIt + cde_id: C18262 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18262" + term_id: C18262 + term_version: 20.10d + +wwtr1: + common: + description: >- + This gene is involved in regulation of transcription. It is involved in fetal/neonatal + cardiac and muscle development. + termDef: + term: >- + WWTR1 Gene + source: NCIt + cde_id: C24844 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24844" + term_id: C24844 + term_version: 20.10d + +wxs: + common: + description: >- + A procedure that can determine the DNA sequence for all of the exons in an individual. + termDef: + term: >- + Whole Exome Sequencing + source: NCIt + cde_id: C101295 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101295" + term_id: C101295 + term_version: 20.10d + +xanthofibroma: + common: + description: >- + A benign neoplasm composed of fibroblastic spindle cells in a whorled storiform + pattern. It is characterized by the presence of foam cells, inflammatory cells, + hemosiderin deposition and stromal hemorrhage. + termDef: + term: >- + Benign Fibrous Histiocytoma + source: NCIt + cde_id: C3739 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3739" + term_id: C3739 + term_version: 20.05a + +xevinapant: + common: + description: >- + An orally available mimetic of the natural second mitochondrial-derived activator + of caspases (Smac) and inhibitor of Inhibitor of Apoptosis Proteins (IAPs), + with potential immunomodulating, apoptotic-inducing, chemo-radio-sensitizing + and antineoplastic activities. Upon oral administration,xevinapant targets and + binds to the Smac binding groove on IAPs, including the direct caspase inhibitor + X chromosome-linked IAP (XIAP), and the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2). + This inhibits the activities of these IAPs and promotes the induction of apoptosis. + Additionally, as xevinapant inhibits the activity of IAPs, it may work synergistically + with cytotoxic drugs and/or radiation to overcome tumor cell resistance to apoptosis. + As IAPs regulate nuclear factor-kappa B (NFkB) signaling pathways, which drives + the expression of genes involved in immune and inflammatory responses, xevinapant + may enhance anti-tumor immune responses when administered with certain immunomodulating + agents, such as immune checkpoint inhibitors. IAPs are overexpressed by many + cancer cell types and suppress both intrinsic and extrinsic apoptosis by binding + to and inhibiting active caspases via their baculoviral lAP repeat (BIR) domains. + They contribute to chemo-radio-resistance of cancer cells to certain cytotoxic + agents and radiation, promote tumor cell survival and are associated with poor + prognosis in certain types of cancer. SMAC, a pro-apoptotic mitochondrial protein, + is an endogenous inhibitor of the IAPs family of cellular proteins. + termDef: + term: >- + Xevinapant + source: NCIt + cde_id: C90574 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C90574" + term_id: C90574 + term_version: 20.10d + +xiliertinib: + common: + description: >- + An orally available, ATP-competitive inhibitor of the epidermal growth factor + receptor (EGFR), with potential antineoplastic activity. Upon oral administration, + xiliertinib binds to and inhibits the activity of EGFR. This prevents EGFR-mediated + signaling, and may lead to both induction of cell death and inhibition of tumor + growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated + in many tumor cell types, plays a key role in tumor cell proliferation and tumor + vascularization. + termDef: + term: >- + Xiliertinib + source: NCIt + cde_id: C162552 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C162552" + term_id: C162552 + term_version: 20.10d + +xisomab_3g3: + common: + description: >- + A humanized anti-factor XI (FXI) antibody, with potential anti-thrombotic activity. + Upon administration, xisomab 3G3 targets and binds to the apple 2 domain of + FXI, thereby preventing the binding of FXI to factor XIIa (FXIIa). This blocks + factor XIIa-mediated FXI activation without inhibiting FXI activation by thrombin + or the procoagulant function of FXIa. The abrogation of FXI activation prolongs + the activated partial thromboplastin time (aPTT), and reduces platelet and fibrin + accumulation. This results in the inhibition of contact activation-initiated + blood coagulation and prevents thrombus formation. FXI contributes to thrombotic + disease while playing a limited role in normal hemostasis. Activation of FXI + is essential for thrombus growth and stabilization. + termDef: + term: >- + Xisomab 3G3 + source: NCIt + cde_id: C171173 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C171173" + term_id: C171173 + term_version: 20.10d + +xpa: + common: + description: >- + This gene facilitates DNA binding in repair processes and is associated with + the disease xeroderma pigmentosum complementation group A. + termDef: + term: >- + XPA Gene + source: NCIt + cde_id: C20361 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20361" + term_id: C20361 + term_version: 20.10d + +xpc: + common: + description: >- + This gene is involved in nucleotide excision repair. + termDef: + term: >- + XPC Gene + source: NCIt + cde_id: C97870 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97870" + term_id: C97870 + term_version: 20.10d + +xpo1: + common: + description: >- + This gene plays a role in the regulation of nuclear export. + termDef: + term: >- + XPO1 Gene + source: NCIt + cde_id: C99484 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99484" + term_id: C99484 + term_version: 20.10d + +yemen: + common: + description: >- + A country in the Middle East, bordering the Arabian Sea, Gulf of Aden, and Red + Sea, between Oman and Saudi Arabia. + termDef: + term: >- + Yemen + source: NCIt + cde_id: C17264 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17264" + term_id: C17264 + term_version: 19.12e + +"yes": + common: + description: >- + The affirmative response to a question. + termDef: + term: >- + Yes + source: NCIt + cde_id: C49488 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49488" + term_id: C49488 + term_version: 19.12e + +yolk_sac_tumor: + common: + description: >- + A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It + is the most common malignant germ cell tumor in the pediatric population. It + occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, + abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor + mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment + includes: surgical resection, radiation, and chemotherapy. This tumor is very + responsive to chemotherapy regimens that include cisplatinum. + termDef: + term: >- + Yolk Sac Tumor + source: NCIt + cde_id: C3011 + cde_version: 20.05a + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3011" + term_id: C3011 + term_version: 20.05a + +yttrium_y_90_tabituximab_barzuxetan: + common: + description: >- + A radioimmunoconjugate composed of a humanized monoclonal antibody (MoAb) OTSA101 + against FZD10 and labeled with yttrium y 90, with potential antineoplastic activity. + The MoAb moiety of yttrium Y 90-labeled anti-FZD10 monoclonal antibody OTSA101 + binds to FZD10, thereby delivering a cytotoxic dose of beta radiation to FZD10 + positive tumor cells. FZD10 (also called CD350), a member of the Frizzled family + of G protein-coupled receptors that is involved in the Wnt/beta-catenin/TCF + signaling pathway, is overexpressed in a variety of cancer cell types but undetectable + in normal, healthy human tissues except for the placenta. + termDef: + term: >- + Yttrium Y 90 Tabituximab Barzuxetan + source: NCIt + cde_id: C99168 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99168" + term_id: C99168 + term_version: 20.10d + +ywhae: + common: + description: >- + This gene plays a role in signaling. + termDef: + term: >- + YWHAE Gene + source: NCIt + cde_id: C101116 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101116" + term_id: C101116 + term_version: 20.10d + +zambia: + common: + description: >- + A country in southern Africa, east of Angola and north of Zimbabwe. + termDef: + term: >- + Zambia + source: NCIt + cde_id: C17267 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17267" + term_id: C17267 + term_version: 19.12e + +zandelisib: + common: + description: >- + An orally bioavailable inhibitor of the delta isoform of phosphatidylinositide + 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, + zandelisib selectively inhibits the delta isoform of PI3K and prevents the activation + of the PI3K/AKT signaling pathway. This both decreases proliferation and induces + cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key + role in the proliferation and survival of hematologic cancer cells. The targeted + inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic + cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial + role in tumor cell regulation and survival. + termDef: + term: >- + Zandelisib + source: NCIt + cde_id: C123925 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123925" + term_id: C123925 + term_version: 20.10d + +zanidatamab: + common: + description: >- + An engineered immunoglobulin G1 (IgG1) bi-specific monoclonal antibody that + targets two different non-overlapping epitopes of the human tumor-associated + antigen (TAA) epidermal growth factor receptor 2 (HER2), ECD2 and ECD4, with + potential immunomodulating and antineoplastic activities. Upon administration, + zanidatamab targets and binds to the two distinct HER2 domains on the tumor + cell surface. This results in dual HER2 signal blockade, HER2 clustering, receptor + internalization and downregulation. This also induces a cytotoxic T-lymphocyte + (CTL) response and antibody-dependent cell-mediated cytotoxicity (ADCC) against + tumor cells that overexpress HER2. Antibody-dependent cellular phagocytosis + (ADCP) is also induced and further stimulates the immune system to kill HER2-overexpressing + tumor cells. The HER2 receptor internalization also further inhibits HER2 activation, + HER2-mediated signaling and HER2-mediated tumor cell growth. HER2, a tyrosine + kinase receptor, is overexpressed by many cancer cell types. + termDef: + term: >- + Zanidatamab + source: NCIt + cde_id: C130010 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C130010" + term_id: C130010 + term_version: 20.10d + +zbtb16: + common: + description: >- + This gene plays a role in apoptosis and regulation of transcription. It is also + involved in cell organization/biogenesis and megakaryocytic development. + termDef: + term: >- + ZBTB16 Gene + source: NCIt + cde_id: C28635 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28635" + term_id: C28635 + term_version: 20.10d + +zcchc8: + common: + description: >- + This gene plays a role in RNA binding. + termDef: + term: >- + ZCCHC8 Gene + source: NCIt + cde_id: C122878 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C122878" + term_id: C122878 + term_version: 20.10d + +zeb1: + common: + description: >- + This gene is involved in the transcriptional repression of interleukin 2. + termDef: + term: >- + ZEB1 Gene + source: NCIt + cde_id: C105605 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C105605" + term_id: C105605 + term_version: 20.10d + +zelavespib: + common: + description: >- + A purine-based heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic + activity. Zelavespib specifically inhibits active Hsp90, thereby inhibiting + its chaperone function and promoting the proteasomal degradation of oncogenic + signaling proteins involved in tumor cell proliferation and survival. This may + result in the inhibition of cellular proliferation in susceptible tumor cell + populations. Hsp90, a molecular chaperone protein, is upregulated in a variety + of tumor cell types. + termDef: + term: >- + Zelavespib + source: NCIt + cde_id: C101227 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101227" + term_id: C101227 + term_version: 20.10d + +zfhx3: + common: + description: >- + This gene is involved in myoblast and neuronal differentiation. + termDef: + term: >- + ZFHX3 Gene + source: NCIt + cde_id: C115424 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C115424" + term_id: C115424 + term_version: 20.10d + +zimbabwe: + common: + description: >- + A country in southern Africa, between South Africa and Zambia, west of Mozambique. + termDef: + term: >- + Zimbabwe + source: NCIt + cde_id: C17268 + cde_version: 19.12e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17268" + term_id: C17268 + term_version: 19.12e + +zmym3: + common: + description: >- + This gene is involved in chromatin modification. + termDef: + term: >- + ZMYM3 Gene + source: NCIt + cde_id: C101617 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101617" + term_id: C101617 + term_version: 20.10d + +znf198: + common: + description: >- + This gene plays a role in transcriptional modulation. + termDef: + term: >- + ZMYM2 Gene + source: NCIt + cde_id: C97873 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97873" + term_id: C97873 + term_version: 20.10d + +znf331: + common: + description: >- + This gene plays a role in transcriptional regulation. + termDef: + term: >- + ZNF331 Gene + source: NCIt + cde_id: C97879 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97879" + term_id: C97879 + term_version: 20.10d + +znf384: + common: + description: >- + This gene is involved in both transcriptional regulation and DNA binding. + termDef: + term: >- + ZNF384 Gene + source: NCIt + cde_id: C97882 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97882" + term_id: C97882 + term_version: 20.10d + +znf429: + common: + description: >- + This gene may play a role in the regulation of gene transcription. + termDef: + term: >- + ZNF429 Gene + source: NCIt + cde_id: C143100 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143100" + term_id: C143100 + term_version: 20.10d + +znf444: + common: + description: >- + This gene is involved in both transcriptional regulation and DNA binding. + termDef: + term: >- + ZNF444 Gene + source: NCIt + cde_id: C106358 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C106358" + term_id: C106358 + term_version: 20.10d + +znf479: + common: + description: >- + This gene may play a role in the regulation of gene transcription. + termDef: + term: >- + ZNF479 Gene + source: NCIt + cde_id: C143103 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C143103" + term_id: C143103 + term_version: 20.10d + +znf521: + common: + description: >- + This gene plays a role in both the positive and negative regulation of transcription. + termDef: + term: >- + ZNF521 Gene + source: NCIt + cde_id: C97885 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C97885" + term_id: C97885 + term_version: 20.10d + +znrf3: + common: + description: >- + This gene is involved in protein ubiquitination and Wnt pathway inhibition. + termDef: + term: >- + ZNRF3 Gene + source: NCIt + cde_id: C118319 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C118319" + term_id: C118319 + term_version: 20.10d + +zorifertinib: + common: + description: >- + An orally available inhibitor of the epidermal growth factor receptor (EGFR), + with potential antineoplastic activity. Upon oral administration, zorifertinib + binds to and inhibits the activity of EGFR as well as certain mutant forms of + EGFR. This prevents EGFR-mediated signaling, and may lead to both induction + of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, + a receptor tyrosine kinase mutated in many tumor cell types, plays a key role + in tumor cell proliferation and tumor vascularization. + termDef: + term: >- + Zorifertinib + source: NCIt + cde_id: C118289 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C118289" + term_id: C118289 + term_version: 20.10d + +zotatifin: + common: + description: >- + A selective inhibitor of the eukaryotic translation initiation factor 4A (eIF4A), + with potential antineoplastic activity. Upon administration of zotatifin, this + agent targets and binds to elF4A, and promotes eIF4A binding to mRNA with specific + polypurine motifs within their 5'-untranslated region (5'-UTR), leading to the + formation of a stable sequence-specific ternary complex with eIF4A and mRNA + (elF4A- zotatifin-mRNA). This results in the translational repression of key + oncogenes and anti-apoptotic proteins involved in tumor cell proliferation, + survival and metastasis, such as KRAS, Myc, myeloid cell leukemia-1 (Mcl-1), + B-cell lymphoma 2 (Bcl-2), cyclin-dependent kinase (CDK) 4 and 6, cyclin D, + fibroblast growth factor receptor (FGFR) 1 and 2, human epidermal growth factor + receptor 2 (HER2; ERBB2), and beta-catenin. The inhibition of the expression + of these oncogenes leads to the inhibition of various oncogenic signal transduction + pathways. This inhibits proliferation and induces apoptosis in tumor cells. + eIF4A, a RNA helicase and the rate-limiting component of the eukaryotic translation + initiation complex, catalyzes the ATP-dependent unwinding of RNA duplexes and + facilitates 43S ribosome scanning within the 5'-UTR. elF4A is activated by various + oncogenic signaling pathways, including RAS/mitogen-activated protein kinase + (MAPK) and phosphatidylinositide 3-kinase (PI3K)/AKT pathways, and regulates + the translation of oncogenes and tumor survival factors with complex secondary + structures within the 5'-UTRs that are required for tumor cell proliferation, + survival and metastasis. + termDef: + term: >- + Zotatifin + source: NCIt + cde_id: C165746 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165746" + term_id: C165746 + term_version: 20.10d + +zotiraciclib_citrate: + common: + description: >- + An orally bioavailable citrate salt form of zotiraciclib a multi-kinase inhibitor + for cyclin dependent kinase (CDK) subtypes 1, 2, 7 and 9, Janus-associated kinase + 2 (JAK2), FMS-related tyrosine kinase 3 (FLT3, FLK2, STK1), with potential antineoplastic + activity. Upon oral administration, CDK/JAK2/FLT3 Inhibitor TG02 binds to and + inhibits the CDK subtypes, JAK2, and FLT3. TG02 also inhibits, to a lesser extent, + TYK2, TYRO3, STAT5 and P38delta. This may result in both an induction of apoptosis + and an inhibition of tumor cell proliferation in cancer cells that overexpress + these kinases. JAK2, often upregulated or mutated in a variety of cancer cells, + mediates STAT3 activation and plays a key role in tumor cell proliferation and + survival. CDKs are serine/threonine kinases that play key roles in the regulation + of the cell cycle and cellular proliferation. FLT3, a class III tyrosine kinase + receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias. + termDef: + term: >- + Zotiraciclib Citrate + source: NCIt + cde_id: C105851 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C105851" + term_id: C105851 + term_version: 20.10d + +zrsr2: + common: + description: >- + This gene is involved in mRNA processing. + termDef: + term: >- + ZRSR2 Gene + source: NCIt + cde_id: C101120 + cde_version: 20.10d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101120" + term_id: C101120 + term_version: 20.10d + +induction: + treatment: + treatment_intent_type: + description: >- + The first choice of treatment for a particular type of cancer. + termDef: + term: >- + Induction Therapy + source: NCIt + cde_id: C158876 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C158876" + term_id: C158876 + term_version: 23.03d + +well_differentiated: + common: + description: >- + Describes tumor cells that generally retain the appearance of normal cells and + tend to grow and spread at a slower rate than undifferentiated or poorly differentiated + tumor cells. + termDef: + term: >- + Well Differentiated + source: NCIt + cde_id: C14171 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C14171" + term_id: C14171 + term_version: 23.03d + +poorly_differentiated: + common: + description: >- + Describes tumor cells that generally have lost most of the appearance of normal + cells. They tend to grow and spread. + termDef: + term: >- + Poorly Differentiated + source: NCIt + cde_id: C14167 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C14167" + term_id: C14167 + term_version: 23.03d + +extravascular_matrix_loops: + common: + description: >- + A microscopic finding indicating the presence or absence of extravascular matrix + loops in uveal melanoma. + termDef: + term: >- + Extravascular Matrix Loops + source: NCIt + cde_id: C111025 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111025" + term_id: C111025 + term_version: 23.03d + +other_complex_extravascular_matrix_patterns: + common: + description: >- + A microscopic finding indicating the presence of patterns formed by malignant + cells outside the blood vessel circulation in uveal melanoma. The patterns are + detectable using PAS stain without counterstaining with hematoxylin. + termDef: + term: >- + Presence of Extravascular Matrix Patterns + source: NCIt + cde_id: C111024 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111024" + term_id: C111024 + term_version: 23.03d + +common_superficial_femoral_vein: + common: + description: >- + A vein that accompanies the common femoral artery and is formed by the confluence + of the femoral vein and the deep femoral vein. + termDef: + term: >- + Common Femoral Vein + source: NCIt + cde_id: C154771 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C154771" + term_id: C154771 + term_version: 23.03d + +inferior_vena_cava: + common: + description: >- + A large vein that returns blood from the lower half of the body to the heart. + termDef: + term: >- + Inferior Vena Cava + source: NCIt + cde_id: C12815 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12815" + term_id: C12815 + term_version: 23.03d + +iliac_vein: + common: + description: >- + Any of the three veins including the common, external and internal iliac veins. + termDef: + term: >- + Iliac Vein + source: NCIt + cde_id: C12734 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12734" + term_id: C12734 + term_version: 23.03d + +renal_vein: + common: + description: >- + The veins which return blood from the kidneys to the vena cava. + termDef: + term: >- + Renal Vein + source: NCIt + cde_id: C33462 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C33462" + term_id: C33462 + term_version: 23.03d + +great_blood_vessel: + common: + description: >- + Any of the major arteries or veins attached to the cardiac atria or ventricles. + This includes the aorta, superior and inferior vena cava and the pulmonary arteries + and veins. + termDef: + term: >- + Great Blood Vessel + source: NCIt + cde_id: C102955 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102955" + term_id: C102955 + term_version: 23.03d + +centimeters: + common: + description: >- + A basic unit of length in the former CGS version of metric system, equal to + one hundredth of a meter or approximately 0.393 700 787 inch. + termDef: + term: >- + Centimeter + source: NCIt + cde_id: C49668 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C49668" + term_id: C49668 + term_version: 23.03d + +millimeters: + common: + description: >- + A metric unit of length equal to one thousandth of a meter (10E-3 meter) or + approximately 0.03937 inch. + termDef: + term: >- + Millimeter + source: NCIt + cde_id: C28251 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C28251" + term_id: C28251 + term_version: 23.03d + +iv: + diagnosis: + clark_level: + description: >- + A morphologic finding indicating that the cutaneous melanoma has invaded the + reticular dermis. + termDef: + term: >- + Clark Level IV + source: NCIt + cde_id: C94815 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94815" + term_id: C94815 + term_version: 23.03d + other_clinical_attribute: + myasthenia_gravis_classification: + description: >- + Myasthenia gravis presenting with severe weakness affecting non-ocular muscles. + May also have ocular muscle weakness of any severity. + termDef: + term: >- + Class IV + source: NCIt + cde_id: C112017 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112017&ns=ncit" + term_id: C112017 + term_version: 23.08d + +v: + diagnosis: + clark_level: + description: >- + A morphologic finding indicating that the cutaneous melanoma has invaded the + subcutaneous tissue. + termDef: + term: >- + Clark Level V + source: NCIt + cde_id: C94816 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C94816" + term_id: C94816 + term_version: 23.03d + other_clinical_attribute: + myasthenia_gravis_classification: + description: >- + Myasthenia gravis presenting with severe muscle weakness that requires intubation, + with or without mechanical ventilation, except when employed during routine + postoperative management. + termDef: + term: >- + Class V + source: NCIt + cde_id: C112018 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112018&ns=ncit" + term_id: C112018 + term_version: 23.08d + +few: + common: + description: >- + An indefinite but relatively small number. + termDef: + term: >- + Few + source: NCIt + cde_id: C64942 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C64942\n" + term_id: C64942 + term_version: 23.03d + +many: + common: + description: >- + An indefinite large quantity that is considered to be greater than several. + termDef: + term: >- + Many + source: NCIt + cde_id: C78728 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C78728" + term_id: C78728 + term_version: 23.03d + +glis2: + common: + description: >- + This gene is involved in transcriptional regulation and signaling pathway modulation. + termDef: + term: >- + GLIS2 Gene + source: NCIt + cde_id: C105900 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C105900" + term_id: C105900 + term_version: 23.03d + +ptp4a1: + common: + description: >- + This gene is involved in liver cell growth and the cellular response to mitogens. + termDef: + term: >- + PTP4A1 Gene + source: NCIt + cde_id: C24704 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C24704" + term_id: C24704 + term_version: 23.03d + +pim3: + common: + description: >- + This gene is involved in serine/threonine kinase activity that inhibits apoptosis, + promotes cell survival and regulates protein translation. + termDef: + term: >- + PIM3 Gene + source: NCIt + cde_id: C178143 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C178143" + term_id: C178143 + term_version: 23.03d + +brd1: + common: + description: >- + This gene is involved in the localization of histone acetyltransferase complexes. + termDef: + term: >- + BRD1 Gene + source: NCIt + cde_id: C185736 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C185736" + term_id: C185736 + term_version: 23.03d + +dot1l: + common: + description: >- + This gene is involved in epigenetic control of gene expression. + termDef: + term: >- + DOT1L Gene + source: NCIt + cde_id: C73677 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C73677" + term_id: C73677 + term_version: 23.03d + +ino80d: + common: + description: >- + This gene plays a role in ATP-dependent chromatin remodeling. + termDef: + term: >- + INO80D Gene + source: NCIt + cde_id: C125258 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C125258" + term_id: C125258 + term_version: 23.03d + +acaca: + common: + description: >- + This gene plays a role in the synthesis of long-chain fatty acids. + termDef: + term: >- + ACACA Gene + source: NCIt + cde_id: C103885 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C103885" + term_id: C103885 + term_version: 23.03d + +btbd18: + common: + description: >- + This gene may be involved in protein ubiquitination. + termDef: + term: >- + BTBD18 Gene + source: NCIt + cde_id: C126629 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126629" + term_id: C126629 + term_version: 23.03d + +cep170b: + common: + description: >- + This gene may be involved in microtubule organization. + termDef: + term: >- + CEP170B Gene + source: NCIt + cde_id: C126611 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126611" + term_id: C126611 + term_version: 23.03d + +fryl: + common: + description: >- + This gene is involved in the regulation of cell shape and polarity. + termDef: + term: >- + FRYL Gene + source: NCIt + cde_id: C126623 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C126623" + term_id: C126623 + term_version: 23.03d + +hmgb3: + common: + description: >- + This gene plays a role in development and the regulation of gene transcription. + termDef: + term: >- + HMGB3 Gene + source: NCIt + cde_id: C20580 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C20580" + term_id: C20580 + term_version: 23.03d + +top2b: + common: + description: >- + This gene is involved in chromosome recombination, DNA replication and the regulation + of DNA topology during transcription. + termDef: + term: >- + TOP2B Gene + source: NCIt + cde_id: C26593 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26593" + term_id: C26593 + term_version: 23.03d + +phf23: + common: + description: >- + This gene may be involved in chromatin remodeling. + termDef: + term: >- + PHF23 Gene + source: NCIt + cde_id: C98035 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C98035" + term_id: C98035 + term_version: 23.03d + +cbfa2t2: + common: + description: >- + This gene may be involved in tumor suppression. + termDef: + term: >- + CBFA2T2 Gene + source: NCIt + cde_id: C104928 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C104928" + term_id: C104928 + term_version: 23.03d + +ubb: + common: + description: >- + This gene is involved in ubiquitin-dependent proteolysis. + termDef: + term: >- + UBB Gene + source: NCIt + cde_id: C38431 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C38431" + term_id: C38431 + term_version: 23.03d + +zeb2: + common: + description: >- + This gene is involved in regulation of transcription. + termDef: + term: >- + ZEB2 Gene + source: NCIt + cde_id: C75441 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C75441" + term_id: C75441 + term_version: 23.03d + +pneumonia_nos: + common: + description: >- + An acute, acute and chronic, or chronic inflammation focally or diffusely affecting + the lung parenchyma, due to infections (viruses, fungi, mycoplasma, or bacteria), + treatment (e.g. radiation), or exposure (inhalation) to chemicals. Symptoms + include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, + and weakness. + termDef: + term: >- + Pneumonia + source: NCIt + cde_id: C3333 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3333" + term_id: C3333 + term_version: 23.03d + +preoperative: + common: + description: >- + Relating to or occurring during the period immediately before a surgical operation. + termDef: + term: >- + Preoperative + source: NCIt + cde_id: C54732 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54732" + term_id: C54732 + term_version: 23.03d + +some_highschool_or_less: + common: + description: >- + Indicates a person has attended high school but did not complete high school + and did not receive a high school diploma. + termDef: + term: >- + Not High School Graduate + source: NCIt + cde_id: C76123 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C76123" + term_id: C76123 + term_version: 23.03d + +some_college_or_vocational_school: + common: + description: >- + Indicates that a person has attended college but that they did not receive any + degree. + termDef: + term: >- + Some College Completion + source: NCIt + cde_id: C67137 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C67137" + term_id: C67137 + term_version: 23.03d + +college_degree: + common: + description: >- + Completion of education at an institution of higher education created to educate + and grant degrees; often a part of a university. + termDef: + term: >- + College Completion + source: NCIt + cde_id: C159746 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C159746" + term_id: C159746 + term_version: 23.03d + +widowed: + common: + description: >- + Indicates a person who is no longer married because of the death of his/her + spouse and has not remarried. + termDef: + term: >- + Widowed + source: NCIt + cde_id: C51775 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51775" + term_id: C51775 + term_version: 23.03d + +married: + common: + description: >- + Indicates a person currently joined in a legally binding matrimonial union. + Classify common law marriage as married. Includes married couples living together + and not living together. + termDef: + term: >- + Married + source: NCIt + cde_id: C51773 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51773" + term_id: C51773 + term_version: 23.03d + +divorced: + common: + description: >- + Indicates a person whose marriage has been legally dissolved and has not remarried. + termDef: + term: >- + Divorced + source: NCIt + cde_id: C51776 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51776" + term_id: C51776 + term_version: 23.03d + +never_married: + common: + description: >- + Indicates a person who has never been married or whose marriages have been annulled. + termDef: + term: >- + Never Married + source: NCIt + cde_id: C51774 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C51774" + term_id: C51774 + term_version: 23.03d + +domestic_partnership: + common: + description: >- + Indicates a person who is a member of an unmarried couple, including same sex + couples, living together in longstanding relationships, that are registered + or unregistered. + termDef: + term: >- + Domestic Partnership + source: NCIt + cde_id: C53262 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53262" + term_id: C53262 + term_version: 23.03d + +separated: + common: + description: >- + A person who is separated from their spouse, whether or not there is a legal + arrangement. + termDef: + term: >- + Separated + source: NCIt + cde_id: C156541 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C156541" + term_id: C156541 + term_version: 23.03d + +dust: + common: + description: >- + A fine powdery material such as dry earth or pollen that can be blown about + in the air. + termDef: + term: >- + Dust + source: NCIt + cde_id: C84281 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84281" + term_id: C84281 + term_version: 23.03d + +radiologic: + common: + description: >- + Imaging results obtained through a radiology procedure. + termDef: + term: >- + Radiologic Finding + source: NCIt + cde_id: C35869 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35869" + term_id: C35869 + term_version: 23.03d + +small_bowel: + common: + description: >- + The section of the intestines between the pylorus and cecum. The small intestine + is approximately 20 feet long and consists of the duodenum, the jejunum, and + the ileum. Its main function is to absorb nutrients from food as the food is + transported to the large intestine. + termDef: + term: >- + Small Intestine + source: NCIt + cde_id: C12386 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C12386" + term_id: C12386 + term_version: 23.03d + +superficial: + common: + description: >- + Of little substance or significance; involving only a surface. + termDef: + term: >- + Superficial + source: NCIt + cde_id: C25239 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25239" + term_id: C25239 + term_version: 23.03d + +deep: + common: + description: >- + Extending relatively far inward. + termDef: + term: >- + Deep + source: NCIt + cde_id: C25240 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C25240" + term_id: C25240 + term_version: 23.03d + +mushroom: + common: + description: >- + A lesion having the shape of a mushroom. + termDef: + term: >- + Mushroom-Shaped Lesion + source: NCIt + cde_id: C111029 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111029" + term_id: C111029 + term_version: 23.03d + +dome: + common: + description: >- + A lesion having the shape of a dome. + termDef: + term: >- + Dome-Shaped Lesion + source: NCIt + cde_id: C54253 + cde_version: 23.03d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C54253" + term_id: C54253 + term_version: 23.03d + +exon: + tag: + name: + description: >- + Exon number targeted or included in a molecular analysis. If a specific genetic + variant is being reported, this property can be used to capture the exon where + that variant is located. + termDef: + term: >- + Molecular Laboratory Procedure Exon Identification Number + source: caDSR + cde_id: 6142411 + cde_version: 1.0 + term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=6142411%20and%20ver_nr=1.0" + +continuous: + common: + description: >- + Remain in force or carry on without letup; keep or maintain in unaltered condition; + exist in time or space without stop or interruption. + termDef: + term: >- + Continue + source: NCIt + cde_id: C53279 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C53279" + term_id: C53279 + term_version: 23.08d + +intermittent: + common: + description: >- + Periodically stopping and starting. + termDef: + term: >- + Intermittent + source: NCIt + cde_id: C71325 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71325" + term_id: C71325 + term_version: 23.08d + +thyroid_gland_isthmus: + common: + description: >- + The narrow, central portion of the thyroid gland that crosses the trachea anteriorly + and connects the lateral lobes of the gland. When present, the normal variant + pyramidal lobe may extend from the isthmus. + termDef: + term: >- + Thyroid Gland Isthmus + source: NCIt + cde_id: C32887 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C32887" + term_id: C32887 + term_version: 23.08d + +home: + common: + description: >- + A person's place of residence. + termDef: + term: >- + Home + source: NCIt + cde_id: C18002 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C18002" + term_id: C18002 + term_version: 23.08d + +social: + common: + description: >- + The surroundings or environment in which social activities occur. + termDef: + term: >- + Social Setting + source: NCIt + cde_id: C102712 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C102712" + term_id: C102712 + term_version: 23.08d + +work: + common: + description: >- + The physical location where work or employment takes place. + termDef: + term: >- + Worksite + source: NCIt + cde_id: C17556 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17556" + term_id: C17556 + term_version: 23.08d + +ultrasound: + common: + description: >- + The use of high-frequency sound waves to generate images of the body. + termDef: + term: >- + Ultrasound Imaging + source: NCIt + cde_id: C17230 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17230" + term_id: C17230 + term_version: 23.08d + +microscopy_nos: + common: + description: >- + The use of various technologies to resolve the structure or features of objects + too small or fine to naturally be seen by eye. + termDef: + term: >- + Microscopy + source: NCIt + cde_id: C16853 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C16853" + term_id: C16853 + term_version: 23.08d + +staining_intensity_0: + common: + description: >- + A measurement of the amount or proportion of tissue or cells that have a staining + intensity of 0. + termDef: + term: >- + Staining Intensity 0 + source: NCIt + cde_id: C186199 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C186199" + term_id: C186199 + term_version: 23.08d + +staining_intensity_1: + common: + description: >- + A measurement of the amount or proportion of tissue or cells that have a staining + intensity of 1+ + termDef: + term: >- + Staining Intensity 1+ + source: NCIt + cde_id: C186200 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C186200" + term_id: C186200 + term_version: 23.08d + +staining_intensity_2: + common: + description: >- + A measurement of the amount or proportion of tissue or cells that have a staining + intensity of 2+ + termDef: + term: >- + Staining Intensity 2+ + source: NCIt + cde_id: C186201 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C186201" + term_id: C186201 + term_version: 23.08d + +staining_intensity_3: + common: + description: >- + A measurement of the amount or proportion of tissue or cells that have a staining + intensity of 3+ + termDef: + term: >- + Staining Intensity 3+ + source: NCIt + cde_id: C186202 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C186202" + term_id: C186202 + term_version: 23.08d + +staining_intensity_4: + common: + description: >- + A measurement of the amount or proportion of tissue or cells that have a staining + intensity of 4+ + termDef: + term: >- + Staining Intensity 4+ + source: + cde_id: + cde_version: + term_url: + +aspirin: + common: + description: >- + An orally administered non-steroidal antiinflammatory agent. Acetylsalicylic + acid binds to and acetylates serine residues in cyclooxygenases, resulting in + decreased synthesis of prostaglandin, platelet aggregation, and inflammation. + This agent exhibits analgesic, antipyretic, and anticoagulant properties. + termDef: + term: >- + Aspirin + source: NCIt + cde_id: C287 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C287" + term_id: C287 + term_version: 23.08d + +metformin: + common: + description: >- + An agent belonging to the biguanide class of antidiabetics with antihyperglycemic + activity. Metformin is associated with a very low incidence of lactic acidosis. + This agent helps reduce LDL cholesterol and triglyceride levels, and is not + associated with weight gain, and prevents the cardiovascular complications of + diabetes. Metformin is not metabolized and is excreted unchanged by the kidneys. + termDef: + term: >- + Metformin + source: NCIt + cde_id: C61612 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61612" + term_id: C61612 + term_version: 23.08d + +acetaminophen: + common: + description: >- + A p-aminophenol derivative with analgesic and antipyretic activities. Although + the exact mechanism through which acetaminophen exert its effects has yet to + be fully determined, acetaminophen may inhibit the nitric oxide (NO) pathway + mediated by a variety of neurotransmitter receptors including N-methyl-D-aspartate + (NMDA) and substance P, resulting in elevation of the pain threshold. The antipyretic + activity may result from inhibition of prostaglandin synthesis and release in + the central nervous system (CNS) and prostaglandin-mediated effects on the heat-regulating + center in the anterior hypothalamus. + termDef: + term: >- + Acetaminophen + source: NCIt + cde_id: C198 + cde_version: 23.08d + term_url: "https://thesaurus.cancer.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C198" + term_id: C198 + term_version: 23.08d + +cd43: + common: + description: >- + Leukosialin (400 aa, ~40 kDa) is encoded by the human SPN gene. This protein + is involved in immune cell function. + termDef: + term: >- + Leukosialin + source: NCIt + cde_id: C101153 + cde_version: 23.08d + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C101153" + term_id: C101153 + term_version: 23.08d diff --git a/server/data_files/GDC/model-3.3.0/aggregated_somatic_mutation.yaml b/server/data_files/GDC/model-3.3.0/aggregated_somatic_mutation.yaml new file mode 100644 index 0000000..61e8370 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/aggregated_somatic_mutation.yaml @@ -0,0 +1,102 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "aggregated_somatic_mutation" +title: Aggregated Somatic Mutation +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + MAF/TSV files that contain all somatic mutations from multiple somatic variant callers + and/or multiple cases. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: projects + backref: aggregated_somatic_mutations + label: derived_from + target_type: project + multiplicity: many_to_one + required: false + - name: somatic_aggregation_workflows + backref: aggregated_somatic_mutations + label: data_from + target_type: somatic_aggregation_workflow + multiplicity: one_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - somatic_aggregation_workflows + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Simple Nucleotide Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - MAF + - TSV + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Aggregated Somatic Mutation + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - miRNA-Seq + - RNA-Seq + - Targeted Sequencing + - WGS + - WXS + + platform: + $ref: + - "read_group.yaml#/properties/platform" + + projects: + $ref: "_definitions.yaml#/to_one_project" + + somatic_aggregation_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/aligned_reads.yaml b/server/data_files/GDC/model-3.3.0/aligned_reads.yaml new file mode 100644 index 0000000..fe9ddc9 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/aligned_reads.yaml @@ -0,0 +1,273 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "aligned_reads" +title: Aligned Reads +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing aligned reads that are generated internally by the GDC. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: alignment_cocleaning_workflows + backref: aligned_reads_files + label: data_from + target_type: alignment_cocleaning_workflow + multiplicity: many_to_one + required: false + - name: alignment_workflows + backref: aligned_reads_files + label: data_from + target_type: alignment_workflow + multiplicity: many_to_one + required: false + - exclusive: true + required: false + subgroup: + - name: submitted_unaligned_reads_files + backref: aligned_reads_files + label: matched_to + target_type: submitted_unaligned_reads + multiplicity: one_to_many + required: false + - name: submitted_aligned_reads_files + backref: aligned_reads_files + label: matched_to + target_type: submitted_aligned_reads + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + average_base_quality: + $ref: + - "_terms.yaml#/average_base_quality/common" + type: number + minimum: 0 + + average_insert_size: + $ref: + - "_terms.yaml#/average_insert_size/common" + type: integer + minimum: 0 + + average_read_length: + $ref: + - "_terms.yaml#/average_read_length/common" + type: integer + minimum: 0 + + contamination: + $ref: + - "_terms.yaml#/contamination/common" + type: number + maximum: 1 + minimum: 0 + + contamination_error: + $ref: + - "_terms.yaml#/contamination_error/common" + type: number + minimum: 0 + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Sequencing Reads + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - BAM + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Aligned Reads + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - HiChIP + - m6A MeRIP-Seq + - miRNA-Seq + - RNA-Seq + - scATAC-Seq + - scRNA-Seq + - Targeted Sequencing + - Validation + - WGS + - WXS + enumDef: + Targeted Sequencing: + $ref: + - "_terms_enum.yaml#/targeted_sequencing/common" + WGS: + $ref: + - "_terms_enum.yaml#/wgs/common" + WXS: + $ref: + - "_terms_enum.yaml#/wxs/common" + + mean_coverage: + $ref: + - "_terms.yaml#/mean_coverage/common" + type: number + minimum: 0 + + msi_score: + description: >- + Numeric score denoting the aligned reads file's MSI score from MSIsensor. + type: number + minimum: 0 + + msi_status: + description: >- + MSIsensor determination of either microsatellite stability or instability. + enum: + - MSI + - MSS + + pairs_on_diff_chr: + $ref: + - "_terms.yaml#/pairs_on_diff_chr/common" + type: integer + minimum: 0 + + platform: + $ref: + - "read_group.yaml#/properties/platform" + + proportion_base_mismatch: + $ref: + - "_terms.yaml#/proportion_base_mismatch/common" + type: number + maximum: 1 + minimum: 0 + + proportion_coverage_10x: + $ref: + - "_terms.yaml#/proportion_coverage_10x/common" + type: number + maximum: 1 + minimum: 0 + + proportion_coverage_30x: + $ref: + - "_terms.yaml#/proportion_coverage_30x/common" + type: number + maximum: 1 + minimum: 0 + + proportion_reads_duplicated: + $ref: + - "_terms.yaml#/proportion_reads_duplicated/common" + type: number + minimum: 0 + + proportion_reads_mapped: + $ref: + - "_terms.yaml#/proportion_reads_mapped/common" + type: number + maximum: 1 + minimum: 0 + + proportion_targets_no_coverage: + $ref: + - "_terms.yaml#/proportion_targets_no_coverage/common" + type: number + maximum: 1 + minimum: 0 + + total_reads: + $ref: + - "_terms.yaml#/total_reads/common" + type: integer + minimum: 0 + + tumor_ploidy: + $ref: + - "_terms.yaml#/tumor_ploidy/common" + type: number + minimum: 0 + + tumor_purity: + $ref: + - "_terms.yaml#/tumor_purity/common" + type: number + maximum: 1 + minimum: 0 + + wgs_coverage: + $ref: + - "_terms.yaml#/wgs_coverage/common" + enum: + - 0x-10x + - 10x-25x + - 25x-150x + - 150x+ + - Unknown + - Not Applicable + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + alignment_cocleaning_workflows: + $ref: "_definitions.yaml#/to_one" + + alignment_workflows: + $ref: "_definitions.yaml#/to_one" + + submitted_unaligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + submitted_aligned_reads_files: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/aligned_reads_index.yaml b/server/data_files/GDC/model-3.3.0/aligned_reads_index.yaml new file mode 100644 index 0000000..d7986d2 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/aligned_reads_index.yaml @@ -0,0 +1,86 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "aligned_reads_index" +title: Aligned Reads Index +type: object +namespace: https://gdc.cancer.gov +category: index_file +project: '*' +program: '*' +description: >- + Data file containing the index for a set of aligned reads. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: submitted_aligned_reads_files + backref: aligned_reads_indexes + label: derived_from + target_type: submitted_aligned_reads + multiplicity: one_to_one + required: false + - name: aligned_reads_files + backref: aligned_reads_indexes + label: derived_from + target_type: aligned_reads + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Sequencing Data + - Sequencing Reads + - Raw Sequencing Data + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Aligned Reads Index + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - BAI + + submitted_aligned_reads_files: + $ref: "_definitions.yaml#/to_one" + + aligned_reads_files: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/alignment_cocleaning_workflow.yaml b/server/data_files/GDC/model-3.3.0/alignment_cocleaning_workflow.yaml new file mode 100644 index 0000000..4c3a881 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/alignment_cocleaning_workflow.yaml @@ -0,0 +1,67 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "alignment_cocleaning_workflow" +title: Alignment Cocleaning Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the alignment and cocleaning pipeline used to align reads in the GDC + harmonization pipelines. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: true + required: true + subgroup: + - name: submitted_aligned_reads_files + backref: alignment_cocleaning_workflows + label: performed_on + target_type: submitted_aligned_reads + multiplicity: one_to_many + required: false + - name: submitted_unaligned_reads_files + backref: alignment_cocleaning_workflows + label: performed_on + target_type: submitted_unaligned_reads + multiplicity: one_to_many + required: false + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - BWA with Mark Duplicates and Cocleaning + + submitted_aligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + submitted_unaligned_reads_files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/alignment_workflow.yaml b/server/data_files/GDC/model-3.3.0/alignment_workflow.yaml new file mode 100644 index 0000000..45f9049 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/alignment_workflow.yaml @@ -0,0 +1,82 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "alignment_workflow" +title: Alignment Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the alignment pipeline used to align reads in the GDC harmonization + pipelines. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: false + required: true + subgroup: + - name: submitted_aligned_reads_files + backref: alignment_workflows + label: performed_on + target_type: submitted_aligned_reads + multiplicity: many_to_many + required: false + - name: submitted_unaligned_reads_files + backref: alignment_workflows + label: performed_on + target_type: submitted_unaligned_reads + multiplicity: many_to_many + required: false + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + type: + enum: + - alignment_workflow + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - BWA + - BWA with BQSR + - BWA with Mark Duplicates and BQSR + - BWA-aln + - BWA-mem + - CellRanger - 10x Chromium + - STAR - Smart-Seq2 + - STAR 2-Pass + - STAR 2-Pass Chimeric + - STAR 2-Pass Genome + - STAR 2-Pass Transcriptome + - zUMIs - Smart-Seq2 + + submitted_aligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + submitted_unaligned_reads_files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/aliquot.yaml b/server/data_files/GDC/model-3.3.0/aliquot.yaml new file mode 100644 index 0000000..9302330 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/aliquot.yaml @@ -0,0 +1,156 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "aliquot" +title: Aliquot +type: object +namespace: https://gdc.cancer.gov +category: biospecimen +project: '*' +program: '*' +description: >- + Pertaining to a portion of the whole; any one of two or more samples of something, + of the same volume or weight. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: true + required: true + subgroup: + - name: analytes + backref: aliquots + label: derived_from + target_type: analyte + multiplicity: many_to_one + required: false + - name: samples + backref: aliquots + label: derived_from + target_type: sample + multiplicity: many_to_many + required: false + - name: centers + backref: aliquots + label: shipped_to + target_type: center + multiplicity: many_to_one + required: false + +required: + - submitter_id + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - analyte_type_id + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + aliquot_quantity: + $ref: + - "_terms.yaml#/aliquot_quantity/common" + type: number + minimum: 0 + + aliquot_volume: + $ref: + - "_terms.yaml#/aliquot_volume/common" + type: number + minimum: 0 + + amount: + $ref: + - "_terms.yaml#/amount/common" + type: number + minimum: 0 + + analyte_type: + $ref: + - "analyte.yaml#/properties/analyte_type" + + analyte_type_id: + $ref: + - "analyte.yaml#/properties/analyte_type_id" + + concentration: + $ref: + - "_terms.yaml#/concentration/common" + type: number + minimum: 0 + + no_matched_normal_low_pass_wgs: + $ref: + - "_terms.yaml#/no_matched_normal_low_pass_wgs/common" + type: boolean + default: false + + no_matched_normal_targeted_sequencing: + $ref: + - "_terms.yaml#/no_matched_normal_targeted_sequencing/common" + type: boolean + default: false + + no_matched_normal_wgs: + $ref: + - "_terms.yaml#/no_matched_normal_wgs/common" + type: boolean + default: false + + no_matched_normal_wxs: + $ref: + - "_terms.yaml#/no_matched_normal_wxs/common" + type: boolean + default: false + + source_center: + $ref: + - "_terms.yaml#/source_center/common" + type: string + + selected_normal_wxs: + $ref: + - "_terms.yaml#/selected_normal_wxs/common" + type: boolean + default: false + + selected_normal_wgs: + $ref: + - "_terms.yaml#/selected_normal_wgs/common" + type: boolean + default: false + + selected_normal_targeted_sequencing: + $ref: + - "_terms.yaml#/selected_normal_targeted_sequencing/common" + type: boolean + default: false + + selected_normal_low_pass_wgs: + $ref: + - "_terms.yaml#/selected_normal_low_pass_wgs/common" + type: boolean + default: false + + analytes: + $ref: "_definitions.yaml#/to_one" + + samples: + $ref: "_definitions.yaml#/to_many" + + centers: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/analysis_metadata.yaml b/server/data_files/GDC/model-3.3.0/analysis_metadata.yaml new file mode 100644 index 0000000..5b2a535 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/analysis_metadata.yaml @@ -0,0 +1,90 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "analysis_metadata" +title: Analysis Metadata +type: object +namespace: https://gdc.cancer.gov +category: metadata_file +project: '*' +program: '*' +description: >- + Data file containing the analysis information from the SRA XML. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: submitted_aligned_reads_files + backref: analysis_metadata_files + label: derived_from + target_type: submitted_aligned_reads + multiplicity: one_to_many + required: false + - name: files + backref: analysis_metadata_files + label: derived_from + target_type: file + multiplicity: one_to_many + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Sequencing Data + - Sequencing Reads + - Raw Sequencing Data + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Analysis Metadata + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - SRA XML + - MAGE-TAB + - SDRF + - IDF + - ADF + + submitted_aligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/analyte.yaml b/server/data_files/GDC/model-3.3.0/analyte.yaml new file mode 100644 index 0000000..c47d9b0 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/analyte.yaml @@ -0,0 +1,202 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "analyte" +title: Analyte +type: object +namespace: https://gdc.cancer.gov +category: biospecimen +project: '*' +program: '*' +description: >- + A liquid bulk product produced according to specified lab protocols, from a sample + or analyte, intended for further analysis. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: true + required: true + subgroup: + - name: portions + backref: analytes + label: derived_from + target_type: portion + multiplicity: many_to_one + required: false + - name: samples + backref: analytes + label: derived_from + target_type: sample + multiplicity: many_to_one + required: false + +required: + - submitter_id + - analyte_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - analyte_type_id + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + a260_a280_ratio: + $ref: + - "_terms.yaml#/a260_a280_ratio/common" + type: number + minimum: 0 + + amount: + $ref: + - "_terms.yaml#/amount/common" + type: number + minimum: 0 + + analyte_quantity: + $ref: + - "_terms.yaml#/analyte_quantity/common" + type: number + minimum: 0 + + analyte_type: + $ref: + - "_terms.yaml#/analyte_type/common" + enum: + - cfDNA + - DNA + - EBV Immortalized Normal + - FFPE DNA + - FFPE RNA + - GenomePlex (Rubicon) Amplified DNA + - m6A Enriched RNA + - Nuclei RNA + - Repli-G (Qiagen) DNA + - Repli-G Pooled (Qiagen) DNA + - Repli-G X (Qiagen) DNA + - RNA + - Total RNA + enumDef: + DNA: + $ref: + - "_terms_enum.yaml#/dna/common" + Total RNA: + $ref: + - "_terms_enum.yaml#/total_rna/common" + + analyte_type_id: + $ref: + - "_terms.yaml#/analyte_type_id/common" + enum: + - D + - E + - G + - H + - R + - S + - T + - W + - X + - Y + + analyte_volume: + $ref: + - "_terms.yaml#/analyte_volume/common" + type: number + minimum: 0 + + concentration: + $ref: + - "_terms.yaml#/concentration/common" + type: number + minimum: 0 + + experimental_protocol_type: + $ref: + - "_terms.yaml#/experimental_protocol_type/common" + enum: + - aDNA Preparation Type + - Allprep FFPE DNA + - Allprep RNA Extraction + - Chemical Lysis DNA Extraction + - Genomplex + - HighPure miRNA (Allprep DNA) FFPE RNA + - mirVana (Allprep DNA) RNA + - nRNA - Melanoma Protocol + - Pre-extracted DNA received by TSS + - Repli-G + - Repli-G X + - Total RNA + enumDef: + Total RNA: + $ref: + - "_terms_enum.yaml#/total_rna/common" + + normal_tumor_genotype_snp_match: + $ref: + - "_terms.yaml#/normal_tumor_genotype_snp_match/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + - Not Allowed To Collect + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ribosomal_rna_28s_16s_ratio: + $ref: + - "_terms.yaml#/ribosomal_rna_28s_16s_ratio/common" + type: number + minimum: 0 + + rna_integrity_number: + $ref: + - "_terms.yaml#/rna_integrity_number/common" + type: number + maximum: 10 + + spectrophotometer_method: + $ref: + - "_terms.yaml#/spectrophotometer_method/common" + type: string + + well_number: + $ref: + - "_terms.yaml#/well_number/common" + type: string + + portions: + $ref: "_definitions.yaml#/to_one" + + samples: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/annotated_somatic_mutation.yaml b/server/data_files/GDC/model-3.3.0/annotated_somatic_mutation.yaml new file mode 100644 index 0000000..a9a729a --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/annotated_somatic_mutation.yaml @@ -0,0 +1,104 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "annotated_somatic_mutation" +title: Annotated Somatic Mutation +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + MAF or VCF files that contain the annotated somatic mutations calls. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: somatic_annotation_workflows + backref: annotated_somatic_mutations + label: data_from + target_type: somatic_annotation_workflow + multiplicity: many_to_one + required: false + - name: genomic_profile_harmonization_workflows + backref: annotated_somatic_mutations + label: data_from + target_type: genomic_profile_harmonization_workflow + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Simple Nucleotide Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - MAF + - VCF + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Annotated Somatic Mutation + - Masked Annotated Somatic Mutation + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - miRNA-Seq + - RNA-Seq + - Targeted Sequencing + - WGS + - WXS + + platform: + $ref: + - "read_group.yaml#/properties/platform" + + somatic_annotation_workflows: + $ref: "_definitions.yaml#/to_one" + + genomic_profile_harmonization_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/annotation.yaml b/server/data_files/GDC/model-3.3.0/annotation.yaml new file mode 100644 index 0000000..c2f6f0b --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/annotation.yaml @@ -0,0 +1,631 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "annotation" +title: Annotation +type: object +namespace: https://gdc.cancer.gov +category: notation +project: '*' +program: '*' +description: >- + An explanatory or critical comment, or other in-context information (e.g., pattern, + motif, link), that has been associated with data or other types of information. + (NCIt C44272) +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: false + required: true + subgroup: + - name: aggregated_somatic_mutations + backref: annotations + label: annotates + target_type: aggregated_somatic_mutation + multiplicity: many_to_many + required: false + - name: aligned_reads_indexes + backref: annotations + label: annotates + target_type: aligned_reads_index + multiplicity: many_to_many + required: false + - name: aligned_reads_files + backref: annotations + label: annotates + target_type: aligned_reads + multiplicity: many_to_many + required: false + - name: aliquots + backref: annotations + label: annotates + target_type: aliquot + multiplicity: many_to_many + required: false + - name: analysis_metadata_files + backref: annotations + label: annotates + target_type: analysis_metadata + multiplicity: many_to_many + required: false + - name: analytes + backref: annotations + label: annotates + target_type: analyte + multiplicity: many_to_many + required: false + - name: annotated_somatic_mutations + backref: annotations + label: annotates + target_type: annotated_somatic_mutation + multiplicity: many_to_many + required: false + - name: archives + backref: annotations + label: annotates + target_type: archive + multiplicity: many_to_many + required: false + - name: biospecimen_supplements + backref: annotations + label: annotates + target_type: biospecimen_supplement + multiplicity: many_to_many + required: false + - name: cases + backref: annotations + label: annotates + target_type: case + multiplicity: many_to_many + required: false + - name: centers + backref: annotations + label: annotates + target_type: center + multiplicity: many_to_many + required: false + - name: clinical_supplements + backref: annotations + label: annotates + target_type: clinical_supplement + multiplicity: many_to_many + required: false + - name: copy_number_auxiliary_files + backref: annotations + label: annotates + target_type: copy_number_auxiliary_file + multiplicity: many_to_many + required: false + - name: copy_number_estimates + backref: annotations + label: annotates + target_type: copy_number_estimate + multiplicity: many_to_many + required: false + - name: copy_number_segments + backref: annotations + label: annotates + target_type: copy_number_segment + multiplicity: many_to_many + required: false + - name: demographics + backref: annotations + label: annotates + target_type: demographic + multiplicity: many_to_many + required: false + - name: diagnoses + backref: annotations + label: annotates + target_type: diagnosis + multiplicity: many_to_many + required: false + - name: experiment_metadata_files + backref: annotations + label: annotates + target_type: experiment_metadata + multiplicity: many_to_many + required: false + - name: exposures + backref: annotations + label: annotates + target_type: exposure + multiplicity: many_to_many + required: false + - name: family_histories + backref: annotations + label: annotates + target_type: family_history + multiplicity: many_to_many + required: false + - name: files + backref: annotations + label: annotates + target_type: file + multiplicity: many_to_many + required: false + - name: filtered_copy_number_segments + backref: annotations + label: annotates + target_type: filtered_copy_number_segment + multiplicity: many_to_many + required: false + - name: follow_ups + backref: annotations + label: annotates + target_type: follow_up + multiplicity: many_to_many + required: false + - name: gene_expressions + backref: annotations + label: annotates + target_type: gene_expression + multiplicity: many_to_many + required: false + - name: germline_mutation_indexes + backref: annotations + label: annotates + target_type: germline_mutation_index + multiplicity: many_to_many + required: false + - name: masked_methylation_arrays + backref: annotations + label: annotates + target_type: masked_methylation_array + multiplicity: many_to_many + required: false + - name: masked_somatic_mutations + backref: annotations + label: annotates + target_type: masked_somatic_mutation + multiplicity: many_to_many + required: false + - name: methylation_beta_values + backref: annotations + label: annotates + target_type: methylation_beta_value + multiplicity: many_to_many + required: false + - name: mirna_expressions + backref: annotations + label: annotates + target_type: mirna_expression + multiplicity: many_to_many + required: false + - name: molecular_tests + backref: annotations + label: annotates + target_type: molecular_test + multiplicity: many_to_many + required: false + - name: other_clinical_attributes + backref: annotations + label: annotates + target_type: other_clinical_attribute + multiplicity: many_to_many + required: false + - name: pathology_details + backref: annotations + label: annotates + target_type: pathology_detail + multiplicity: many_to_many + required: false + - name: pathology_reports + backref: annotations + label: annotates + target_type: pathology_report + multiplicity: many_to_many + required: false + - name: portions + backref: annotations + label: annotates + target_type: portion + multiplicity: many_to_many + required: false + - name: protein_expressions + backref: annotations + label: annotates + target_type: protein_expression + multiplicity: many_to_many + required: false + - name: raw_methylation_arrays + backref: annotations + label: annotates + target_type: raw_methylation_array + multiplicity: many_to_many + required: false + - name: read_group_qcs + backref: annotations + label: annotates + target_type: read_group_qc + multiplicity: many_to_many + required: false + - name: read_groups + backref: annotations + label: annotates + target_type: read_group + multiplicity: many_to_many + required: false + - name: run_metadata_files + backref: annotations + label: annotates + target_type: run_metadata + multiplicity: many_to_many + required: false + - name: samples + backref: annotations + label: annotates + target_type: sample + multiplicity: many_to_many + required: false + - name: secondary_expression_analyses + backref: annotations + label: annotates + target_type: secondary_expression_analysis + multiplicity: many_to_many + required: false + - name: simple_germline_variations + backref: annotations + label: annotates + target_type: simple_germline_variation + multiplicity: many_to_many + required: false + - name: simple_somatic_mutations + backref: annotations + label: annotates + target_type: simple_somatic_mutation + multiplicity: many_to_many + required: false + - name: slide_images + backref: annotations + label: annotates + target_type: slide_image + multiplicity: many_to_many + required: false + - name: slides + backref: annotations + label: annotates + target_type: slide + multiplicity: many_to_many + required: false + - name: somatic_mutation_indexes + backref: annotations + label: annotates + target_type: somatic_mutation_index + multiplicity: many_to_many + required: false + - name: structural_variations + backref: annotations + label: annotates + target_type: structural_variation + multiplicity: many_to_many + required: false + - name: submitted_aligned_reads_files + backref: annotations + label: annotates + target_type: submitted_aligned_reads + multiplicity: many_to_many + required: false + - name: submitted_expression_arrays + backref: annotations + label: annotates + target_type: submitted_expression_array + multiplicity: many_to_many + required: false + - name: submitted_genomic_profiles + backref: annotations + label: annotates + target_type: submitted_genomic_profile + multiplicity: many_to_many + required: false + - name: submitted_genotyping_arrays + backref: annotations + label: annotates + target_type: submitted_genotyping_array + multiplicity: many_to_many + required: false + - name: submitted_methylation_beta_values + backref: annotations + label: annotates + target_type: submitted_methylation_beta_value + multiplicity: many_to_many + required: false + - name: submitted_tangent_copy_numbers + backref: annotations + label: annotates + target_type: submitted_tangent_copy_number + multiplicity: many_to_many + required: false + - name: submitted_unaligned_reads_files + backref: annotations + label: annotates + target_type: submitted_unaligned_reads + multiplicity: many_to_many + required: false + - name: tissue_source_sites + backref: annotations + label: annotates + target_type: tissue_source_site + multiplicity: many_to_many + required: false + - name: treatments + backref: annotations + label: annotates + target_type: treatment + multiplicity: many_to_many + required: false + +required: + - submitter_id + - category + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + category: + description: >- + Top level characterization of the annotation. + enum: + - Acceptable treatment for TCGA tumor + - Administrative Compliance + - Alternate sample pipeline + - BCR Notification + - Barcode incorrect + - Biospecimen identity unknown + - Case submitted is found to be a recurrence after submission + - Center QC failed + - Clinical data insufficient + - Duplicate case + - Duplicate item + - General + - Genotype mismatch + - History of acceptable prior treatment related to a prior/other malignancy + - History of unacceptable prior treatment related to a prior/other malignancy + - Inadvertently shipped + - Item does not meet study protocol + - Item flagged DNU + - Item Flagged Low Quality + - Item in special subset + - Item is noncanonical + - Item may not meet study protocol + - Molecular analysis outside specification + - Neoadjuvant therapy + - New notification type + - New observation type + - Normal class but appears diseased + - Normal tissue origin incorrect + - Observation + - Pathology outside specification + - Permanently missing item or object + - Prior malignancy + - Qualification metrics changed + - Qualified in error + - Sample compromised + - Subject identity unknown + - Subject withdrew consent + - Synchronous malignancy + - Tumor class but appears normal + - Tumor tissue origin incorrect + - Tumor type incorrect + - WGA Failure + + classification: + description: >- + Top level classification of the annotation. + enum: + - Blocking Release + - CenterNotification + - Complete Data Freeze + - Downstream Data Freeze + - Notification + - Observation + - Redaction + + creator: + description: >- + Name of the person or entity responsible for the creation of the annotation. + type: string + + notes: + description: >- + Open entry for any further description or characterization of the data. + type: string + + status: + description: >- + Status of the annotation. + enum: + - Approved + - Rescinded + + legacy_created_datetime: + $ref: + - "_definitions.yaml#/datetime" + + legacy_updated_datetime: + $ref: + - "_definitions.yaml#/datetime" + + aggregated_somatic_mutations: + $ref: "_definitions.yaml#/to_many" + + aligned_reads_indexes: + $ref: "_definitions.yaml#/to_many" + + aligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + aliquots: + $ref: "_definitions.yaml#/to_many" + + analysis_metadata_files: + $ref: "_definitions.yaml#/to_many" + + analytes: + $ref: "_definitions.yaml#/to_many" + + annotated_somatic_mutations: + $ref: "_definitions.yaml#/to_many" + + archives: + $ref: "_definitions.yaml#/to_many" + + biospecimen_supplements: + $ref: "_definitions.yaml#/to_many" + + cases: + $ref: "_definitions.yaml#/to_many" + + centers: + $ref: "_definitions.yaml#/to_many" + + clinical_supplements: + $ref: "_definitions.yaml#/to_many" + + copy_number_auxiliary_files: + $ref: "_definitions.yaml#/to_many" + + copy_number_estimates: + $ref: "_definitions.yaml#/to_many" + + copy_number_segments: + $ref: "_definitions.yaml#/to_many" + + demographics: + $ref: "_definitions.yaml#/to_many" + + diagnoses: + $ref: "_definitions.yaml#/to_many" + + experiment_metadata_files: + $ref: "_definitions.yaml#/to_many" + + exposures: + $ref: "_definitions.yaml#/to_many" + + family_histories: + $ref: "_definitions.yaml#/to_many" + + files: + $ref: "_definitions.yaml#/to_many" + + filtered_copy_number_segments: + $ref: "_definitions.yaml#/to_many" + + follow_ups: + $ref: "_definitions.yaml#/to_many" + + gene_expressions: + $ref: "_definitions.yaml#/to_many" + + germline_mutation_indexes: + $ref: "_definitions.yaml#/to_many" + + masked_methylation_arrays: + $ref: "_definitions.yaml#/to_many" + + masked_somatic_mutations: + $ref: "_definitions.yaml#/to_many" + + methylation_beta_values: + $ref: "_definitions.yaml#/to_many" + + mirna_expressions: + $ref: "_definitions.yaml#/to_many" + + molecular_tests: + $ref: "_definitions.yaml#/to_many" + + other_clinical_attributes: + $ref: "_definitions.yaml#/to_many" + + pathology_details: + $ref: "_definitions.yaml#/to_many" + + pathology_reports: + $ref: "_definitions.yaml#/to_many" + + portions: + $ref: "_definitions.yaml#/to_many" + + protein_expressions: + $ref: "_definitions.yaml#/to_many" + + raw_methylation_arrays: + $ref: "_definitions.yaml#/to_many" + + read_group_qcs: + $ref: "_definitions.yaml#/to_many" + + read_groups: + $ref: "_definitions.yaml#/to_many" + + run_metadata_files: + $ref: "_definitions.yaml#/to_many" + + samples: + $ref: "_definitions.yaml#/to_many" + + secondary_expression_analyses: + $ref: "_definitions.yaml#/to_many" + + simple_germline_variations: + $ref: "_definitions.yaml#/to_many" + + simple_somatic_mutations: + $ref: "_definitions.yaml#/to_many" + + slide_images: + $ref: "_definitions.yaml#/to_many" + + slides: + $ref: "_definitions.yaml#/to_many" + + somatic_mutation_indexes: + $ref: "_definitions.yaml#/to_many" + + structural_variations: + $ref: "_definitions.yaml#/to_many" + + submitted_aligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + submitted_expression_arrays: + $ref: "_definitions.yaml#/to_many" + + submitted_genomic_profiles: + $ref: "_definitions.yaml#/to_many" + + submitted_genotyping_arrays: + $ref: "_definitions.yaml#/to_many" + + submitted_methylation_beta_values: + $ref: "_definitions.yaml#/to_many" + + submitted_tangent_copy_numbers: + $ref: "_definitions.yaml#/to_many" + + submitted_unaligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + tissue_source_sites: + $ref: "_definitions.yaml#/to_many" + + treatments: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/archive.yaml b/server/data_files/GDC/model-3.3.0/archive.yaml new file mode 100644 index 0000000..b6b391b --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/archive.yaml @@ -0,0 +1,90 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "archive" +title: Archive +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + A group of files containing program or project related data ingested by the GDC. + Archives may be submitted directly to GDC by a center, assembled by the GDC, or + obtained by another route. (GDC subclass of NCIt C114463) +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: projects + backref: archives + label: member_of + target_type: project + multiplicity: many_to_one + required: true + - name: related_to_files + backref: related_archives + label: related_to + target_type: file + multiplicity: one_to_many + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - state + - revision + - projects + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Archive + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - TCGA DCC Archive + - TARGET DCC Archive + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TARGZ + - MAGETAB + + revision: + description: >- + The revision of this archive in the DCC. + type: number + + projects: + $ref: "_definitions.yaml#/to_one_project" + + related_to_files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/biospecimen_supplement.yaml b/server/data_files/GDC/model-3.3.0/biospecimen_supplement.yaml new file mode 100644 index 0000000..cd4e4cc --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/biospecimen_supplement.yaml @@ -0,0 +1,89 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "biospecimen_supplement" +title: Biospecimen Supplement +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing biospecimen metadata information. +additionalProperties: false +submittable: true +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: cases + backref: biospecimen_supplements + label: derived_from + target_type: case + multiplicity: many_to_many + required: true + - name: archives + backref: biospecimen_supplements + label: member_of + target_type: archive + multiplicity: many_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Biospecimen + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Biospecimen Supplement + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - BCR Auxiliary XML + - BCR Biotab + - BCR SSF XML + - BCR PPS XML + - BCR XML + - CDC JSON + - FoundationOne XML + - TSV + - XLSX + + cases: + $ref: "_definitions.yaml#/to_many" + + archives: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/case.yaml b/server/data_files/GDC/model-3.3.0/case.yaml new file mode 100644 index 0000000..8b05b19 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/case.yaml @@ -0,0 +1,272 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "case" +title: Case +type: object +namespace: https://gdc.cancer.gov +category: administrative +project: '*' +program: '*' +description: >- + The collection of all data related to a specific subject in the context of a specific + project. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: projects + backref: cases + label: member_of + target_type: project + multiplicity: many_to_one + required: true + - name: tissue_source_sites + backref: cases + label: processed_at + target_type: tissue_source_site + multiplicity: many_to_one + required: false + +required: + - submitter_id + - disease_type + - primary_site + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + consent_type: + $ref: + - "_terms.yaml#/consent_type/common" + enum: + - Consent by Death + - Consent Exemption + - Consent Waiver + - Informed Consent + + days_to_consent: + $ref: + - "_terms.yaml#/days_to_consent/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_lost_to_followup: + $ref: + - "_terms.yaml#/days_to_lost_to_followup/common" + type: integer + maximum: 32872 + minimum: -32872 + + disease_type: + $ref: + - "_terms.yaml#/disease_type/common" + enum: + - Acinar Cell Neoplasms + - Adenomas and Adenocarcinomas + - Adnexal and Skin Appendage Neoplasms + - Basal Cell Neoplasms + - Blood Vessel Tumors + - Chronic Myeloproliferative Disorders + - Complex Epithelial Neoplasms + - Complex Mixed and Stromal Neoplasms + - Cystic, Mucinous and Serous Neoplasms + - Ductal and Lobular Neoplasms + - Epithelial Neoplasms, NOS + - Fibroepithelial Neoplasms + - Fibromatous Neoplasms + - Germ Cell Neoplasms + - Giant Cell Tumors + - Gliomas + - Granular Cell Tumors and Alveolar Soft Part Sarcomas + - Hodgkin Lymphoma + - Immunoproliferative Diseases + - Leukemias, NOS + - Lipomatous Neoplasms + - Lymphatic Vessel Tumors + - Lymphoid Leukemias + - Malignant Lymphomas, NOS or Diffuse + - Mast Cell Tumors + - Mature B-Cell Lymphomas + - Mature T- and NK-Cell Lymphomas + - Meningiomas + - Mesonephromas + - Mesothelial Neoplasms + - Miscellaneous Bone Tumors + - Miscellaneous Tumors + - Mucoepidermoid Neoplasms + - Myelodysplastic Syndromes + - Myeloid Leukemias + - Myomatous Neoplasms + - Myxomatous Neoplasms + - Neoplasms of Histiocytes and Accessory Lymphoid Cells + - Neoplasms, NOS + - Nerve Sheath Tumors + - Neuroepitheliomatous Neoplasms + - Nevi and Melanomas + - Odontogenic Tumors + - Osseous and Chondromatous Neoplasms + - Other Hematologic Disorders + - Other Leukemias + - Paragangliomas and Glomus Tumors + - Plasma Cell Tumors + - Precursor Cell Lymphoblastic Lymphoma + - Soft Tissue Tumors and Sarcomas, NOS + - Specialized Gonadal Neoplasms + - Squamous Cell Neoplasms + - Synovial-like Neoplasms + - Thymic Epithelial Neoplasms + - Transitional Cell Papillomas and Carcinomas + - Trophoblastic neoplasms + - Unknown + - Not Reported + - Not Applicable + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + index_date: + $ref: + - "_terms.yaml#/index_date/common" + enum: + - Diagnosis + - First Patient Visit + - First Treatment + - Initial Genomic Sequencing + - Recurrence + - Sample Procurement + - Study Enrollment + + lost_to_followup: + $ref: + - "_terms.yaml#/lost_to_followup/common" + enum: + - "Yes" + - "No" + - Unknown + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + primary_site: + $ref: + - "_terms.yaml#/primary_site/common" + enum: + - Accessory sinuses + - Adrenal gland + - Anus and anal canal + - Base of tongue + - Bladder + - Bones, joints and articular cartilage of limbs + - Bones, joints and articular cartilage of other and unspecified sites + - Brain + - Breast + - Bronchus and lung + - Cervix uteri + - Colon + - Connective, subcutaneous and other soft tissues + - Corpus uteri + - Esophagus + - Eye and adnexa + - Floor of mouth + - Gallbladder + - Gum + - Heart, mediastinum, and pleura + - Hematopoietic and reticuloendothelial systems + - Hypopharynx + - Kidney + - Larynx + - Lip + - Liver and intrahepatic bile ducts + - Lymph nodes + - Meninges + - Nasal cavity and middle ear + - Nasopharynx + - Oropharynx + - Other and ill-defined digestive organs + - Other and ill-defined sites + - Other and ill-defined sites in lip, oral cavity and pharynx + - Other and ill-defined sites within respiratory system and intrathoracic organs + - Other and unspecified female genital organs + - Other and unspecified major salivary glands + - Other and unspecified male genital organs + - Other and unspecified parts of biliary tract + - Other and unspecified parts of mouth + - Other and unspecified parts of tongue + - Other and unspecified urinary organs + - Other endocrine glands and related structures + - Ovary + - Palate + - Pancreas + - Parotid gland + - Penis + - Peripheral nerves and autonomic nervous system + - Placenta + - Prostate gland + - Pyriform sinus + - Rectosigmoid junction + - Rectum + - Renal pelvis + - Retroperitoneum and peritoneum + - Skin + - Small intestine + - Spinal cord, cranial nerves, and other parts of central nervous system + - Stomach + - Testis + - Thymus + - Thyroid gland + - Tonsil + - Trachea + - Ureter + - Uterus, NOS + - Vagina + - Vulva + - Unknown + - Not Reported + - Not Applicable + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + projects: + $ref: "_definitions.yaml#/to_one_project" + + tissue_source_sites: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/center.yaml b/server/data_files/GDC/model-3.3.0/center.yaml new file mode 100644 index 0000000..9e8b2fd --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/center.yaml @@ -0,0 +1,70 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "center" +title: Center +type: object +namespace: https://gdc.cancer.gov +category: administrative +project: '*' +program: '*' +description: >- + A Professional Organization or Group which has or is able to submit data to the + GDC that are valid with respect to GDC prescribed or defined data formats. (GDC + subclass of NCIt C19711) +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: [] + +required: + - code + - namespace + - name + - short_name + - center_type + +uniqueKeys: + - [id] + - [code] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + description: >- + UUID for the center. + + code: + description: >- + Numeric code for the center. + type: string + + namespace: + description: >- + Domain name of the center (e.g. broad.mit.edu). + type: string + + name: + description: >- + Name of the center (e.g. Broad Institute of MIT and Harvard). + type: string + + short_name: + description: >- + Shortened name of the center (e.g. BI). + type: string + + center_type: + description: >- + Type classification of the center (e.g. CGCC). + type: string diff --git a/server/data_files/GDC/model-3.3.0/clinical.yaml b/server/data_files/GDC/model-3.3.0/clinical.yaml new file mode 100644 index 0000000..ae99911 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/clinical.yaml @@ -0,0 +1,159 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "clinical" +title: Clinical +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Data obtained through patient examination or treatment. (GDC synonym for NCIt C15783) +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: cases + backref: clinicals + label: describes + target_type: case + multiplicity: one_to_one + required: true + +required: + - id + - submitter_id + - cases + +uniqueKeys: + - [id] + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + age_at_diagnosis: + description: >- + Age in days at which a condition or disease was first diagnosed. CDE: 3225640. + TCGA has the age in years with CDE 2006657, this is converted by ceil(age*365.25) + to get days. + type: number + + days_to_death: + description: >- + Time interval from a person's date of death to the date of initial pathologic + diagnosis, represented as a calculated number of days. CDE: 3165475. + type: number + + gender: + description: >- + Text designations that identify gender. Gender is described as the assemblage + of properties that distinguish people on the basis of their societal roles. + CDE: 2200604 + enum: + - female + - male + - unknown + - unspecified + enumDef: + female: + $ref: + - "_terms_enum.yaml#/female/common" + male: + $ref: + - "_terms_enum.yaml#/male/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + unspecified: + $ref: + - "_terms_enum.yaml#/unspecified/common" + + ethnicity: + description: >- + The text for reporting information about ethnicity based on the Office of Management + and Budget (OMB) categories. CDE: 2192217. + enum: + - hispanic or latino + - not hispanic or latino + enumDef: + hispanic or latino: + $ref: + - "_terms_enum.yaml#/hispanic_or_latino/common" + not hispanic or latino: + $ref: + - "_terms_enum.yaml#/not_hispanic_or_latino/common" + + icd_10: + description: >- + The tenth version of the International Classification of Disease (ICD), published + by the World Health Organization in 1992. A system of numbered categories for + representation of data. CDE: 3226287. + type: string + + race: + description: >- + The text for reporting information about race based on the Office of Management + and Budget (OMB) categories. CDE: 2192199. + enum: + - not reported + - white + - american indian or alaska native + - black or african american + - asian + - native hawaiian or other pacific islander + - other + enumDef: + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + american indian or alaska native: + $ref: + - "_terms_enum.yaml#/american_indian_or_alaska_native/common" + black or african american: + $ref: + - "_terms_enum.yaml#/black_or_african_american/common" + asian: + $ref: + - "_terms_enum.yaml#/asian/common" + native hawaiian or other pacific islander: + $ref: + - "_terms_enum.yaml#/native_hawaiian_or_other_pacific_islander/common" + other: + $ref: + - "_terms_enum.yaml#/other/common" + + vital_status: + description: >- + The survival state of the person registered on the protocol. CDE: 5. + enum: + - alive + - dead + - lost to follow-up + enumDef: + alive: + $ref: + - "_terms_enum.yaml#/alive/common" + dead: + $ref: + - "_terms_enum.yaml#/dead/common" + + year_of_diagnosis: + description: >- + Numeric value to represent the year of an individual's initial pathologic diagnosis + of cancer. CDE: 2896960. + type: number + + cases: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/clinical_supplement.yaml b/server/data_files/GDC/model-3.3.0/clinical_supplement.yaml new file mode 100644 index 0000000..dfed076 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/clinical_supplement.yaml @@ -0,0 +1,87 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "clinical_supplement" +title: Clinical Supplement +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing clinical metadata information. +additionalProperties: false +submittable: true +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: cases + backref: clinical_supplements + label: derived_from + target_type: case + multiplicity: many_to_many + required: true + - name: archives + backref: clinical_supplements + label: member_of + target_type: archive + multiplicity: many_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Clinical + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Clinical Supplement + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - BCR Biotab + - BCR OMF XML + - BCR XML + - CDC JSON + - FoundationOne XML + - TSV + - XLSX + + cases: + $ref: "_definitions.yaml#/to_many" + + archives: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/copy_number_auxiliary_file.yaml b/server/data_files/GDC/model-3.3.0/copy_number_auxiliary_file.yaml new file mode 100644 index 0000000..deefd2d --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/copy_number_auxiliary_file.yaml @@ -0,0 +1,97 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "copy_number_auxiliary_file" +title: Copy Number Auxiliary File +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file related to the copy number pipeline that contains any outputs not strictly defined in other nodes +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: somatic_copy_number_workflows + backref: copy_number_auxiliary_files + label: derived_from + target_type: somatic_copy_number_workflow + multiplicity: one_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - curated_model_index + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + curated_model_index: + $ref: + - "_terms.yaml#/curated_model_index/common" + type: integer + minimum: 1 + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Copy Number Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - PDF + - TAR + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - CNV Model + - Intermediate Analysis Archive + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - WGS + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Illumina + + somatic_copy_number_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/copy_number_estimate.yaml b/server/data_files/GDC/model-3.3.0/copy_number_estimate.yaml new file mode 100644 index 0000000..091204c --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/copy_number_estimate.yaml @@ -0,0 +1,116 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "copy_number_estimate" +title: Copy Number Estimate +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing copy number variation information generated internally by the + GDC. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: copy_number_variation_workflows + backref: copy_number_estimates + label: derived_from + target_type: copy_number_variation_workflow + multiplicity: one_to_one + required: false + - name: genomic_profile_harmonization_workflows + backref: copy_number_estimates + label: derived_from + target_type: genomic_profile_harmonization_workflow + multiplicity: one_to_one + required: false + - name: somatic_copy_number_workflows + backref: copy_number_estimates + label: derived_from + target_type: somatic_copy_number_workflow + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Copy Number Variation + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Gene Level Copy Number + - Gene Level Copy Number Scores + - Cohort Level Copy Number Scores + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TSV + - TXT + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Genotyping Array + - Targeted Sequencing + - WGS + - WXS + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Affymetrix SNP 6.0 + - Illumina + - Ion Torrent + + copy_number_variation_workflows: + $ref: "_definitions.yaml#/to_one" + + genomic_profile_harmonization_workflows: + $ref: "_definitions.yaml#/to_one" + + somatic_copy_number_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/copy_number_liftover_workflow.yaml b/server/data_files/GDC/model-3.3.0/copy_number_liftover_workflow.yaml new file mode 100644 index 0000000..30aa5b3 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/copy_number_liftover_workflow.yaml @@ -0,0 +1,55 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "copy_number_liftover_workflow" +title: Copy Number Liftover Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the copy number liftover workflow used to harmonize TCGA copy number + data. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: submitted_tangent_copy_numbers + backref: copy_number_liftover_workflows + label: performed_on + target_type: submitted_tangent_copy_number + multiplicity: one_to_one + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - DNAcopy + + submitted_tangent_copy_numbers: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/copy_number_segment.yaml b/server/data_files/GDC/model-3.3.0/copy_number_segment.yaml new file mode 100644 index 0000000..cca4374 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/copy_number_segment.yaml @@ -0,0 +1,147 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "copy_number_segment" +title: Copy Number Segment +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing the copy number data from a copy number liftover workflow. + Contains all copy numbers detected. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: copy_number_liftover_workflows + backref: copy_number_segments + label: derived_from + target_type: copy_number_liftover_workflow + multiplicity: one_to_one + required: false + - name: genomic_profile_harmonization_workflows + backref: copy_number_segments + label: derived_from + target_type: genomic_profile_harmonization_workflow + multiplicity: one_to_one + required: false + - name: somatic_copy_number_workflows + backref: copy_number_segments + label: derived_from + target_type: somatic_copy_number_workflow + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + cancer_dna_fraction: + $ref: + - "_terms.yaml#/cancer_dna_fraction/common" + type: number + maximum: 1 + minimum: 0 + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Copy Number Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TXT + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Allele-specific Copy Number Segment + - Copy Number Segment + - Masked Copy Number Segment + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Genotyping Array + - Targeted Sequencing + - WGS + - WXS + + genome_doubling: + $ref: + - "_terms.yaml#/genome_doubling/common" + type: integer + minimum: 0 + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Affymetrix SNP 6.0 + - Illumina + + subclonal_genome_fraction: + $ref: + - "_terms.yaml#/subclonal_genome_fraction/common" + type: number + maximum: 1 + minimum: 0 + + tumor_ploidy: + $ref: + - "_terms.yaml#/tumor_ploidy/common" + type: number + minimum: 0 + + tumor_purity: + $ref: + - "_terms.yaml#/tumor_purity/common" + type: number + maximum: 1 + minimum: 0 + + copy_number_liftover_workflows: + $ref: "_definitions.yaml#/to_one" + + genomic_profile_harmonization_workflows: + $ref: "_definitions.yaml#/to_one" + + somatic_copy_number_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/copy_number_variation_workflow.yaml b/server/data_files/GDC/model-3.3.0/copy_number_variation_workflow.yaml new file mode 100644 index 0000000..76a1812 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/copy_number_variation_workflow.yaml @@ -0,0 +1,58 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "copy_number_variation_workflow" +title: Copy Number Variation Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the Copy Number Variation pipeline used to estimate copy number changes + from different molecular data sources. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: copy_number_segments + backref: copy_number_variation_workflows + label: performed_on + target_type: copy_number_segment + multiplicity: many_to_many + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - GISTIC - Copy Number Score + - GISTIC - Arm Level Copy Number + - GISTIC - Focal Deletion + - GISTIC - Focal Amplification + + copy_number_segments: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/data_format.yaml b/server/data_files/GDC/model-3.3.0/data_format.yaml new file mode 100644 index 0000000..1041653 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/data_format.yaml @@ -0,0 +1,42 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "data_format" +title: Data Format +type: object +namespace: https://gdc.cancer.gov +category: TBD +project: '*' +program: '*' +description: >- + Data format of a legacy file (deprecated). +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: [] + +required: + - name + +uniqueKeys: + - [id] + - [name] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + + name: + description: >- + name of this data format + type: string diff --git a/server/data_files/GDC/model-3.3.0/data_release.yaml b/server/data_files/GDC/model-3.3.0/data_release.yaml new file mode 100644 index 0000000..dc23058 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/data_release.yaml @@ -0,0 +1,84 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "data_release" +title: Data Release +type: object +namespace: https://gdc.cancer.gov +category: data +project: '*' +program: '*' +description: >- + Internal node to store different data releases. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - created_datetime + - updated_datetime + +links: + - name: roots + backref: data_releases + label: describes + target_type: root + multiplicity: many_to_one + required: true + +required: + - name + - major_version + - minor_version + - type + +uniqueKeys: + - [id] + +properties: + + type: + enum: + - data_release + + id: + $ref: + - "_definitions.yaml#/uuid" + + created_datetime: + $ref: + - "_definitions.yaml#/datetime" + + updated_datetime: + $ref: + - "_definitions.yaml#/datetime" + + name: + description: >- + String representing release name. + type: string + + major_version: + description: >- + The number identifying the major version. + type: integer + + minor_version: + description: >- + The number identifying the minor version. + type: integer + + release_date: + $ref: + - "_definitions.yaml#/datetime" + + released: + description: >- + Indicates if it is the current release. + type: boolean + default: false + + roots: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/data_subtype.yaml b/server/data_files/GDC/model-3.3.0/data_subtype.yaml new file mode 100644 index 0000000..f41beb8 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/data_subtype.yaml @@ -0,0 +1,52 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "data_subtype" +title: Data Subtype +type: object +namespace: https://gdc.cancer.gov +category: TBD +project: '*' +program: '*' +description: >- + Data subtype of a legacy file (deprecated). +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: + - name: data_types + backref: data_subtypes + label: member_of + target_type: data_type + multiplicity: many_to_one + required: true + +required: + - name + - data_types + +uniqueKeys: + - [id] + - [name] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + + name: + description: >- + name of this data subtype + type: string + + data_types: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/data_type.yaml b/server/data_files/GDC/model-3.3.0/data_type.yaml new file mode 100644 index 0000000..98fd56f --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/data_type.yaml @@ -0,0 +1,41 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "data_type" +title: Data Type +type: object +namespace: https://gdc.cancer.gov +category: TBD +project: '*' +program: '*' +description: >- + Data type of a legacy file (deprecated). +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: [] + +required: + - name + +uniqueKeys: + - [id] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + + name: + description: >- + name of this data type + type: string diff --git a/server/data_files/GDC/model-3.3.0/demographic.yaml b/server/data_files/GDC/model-3.3.0/demographic.yaml new file mode 100644 index 0000000..4d82ad8 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/demographic.yaml @@ -0,0 +1,2275 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "demographic" +title: Demographic +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Data for the characterization of the patient by means of segmenting the population + (e.g., characterization by age, sex, or race). +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: cases + backref: demographics + label: describes + target_type: case + multiplicity: one_to_one + required: true + +required: + - submitter_id + - ethnicity + - gender + - race + - vital_status + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - premature_at_birth + - weeks_gestation_at_birth + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + age_at_index: + $ref: + - "_terms.yaml#/age_at_index/common" + oneOf: + - type: integer + maximum: 89 + minimum: 0 + - type: "null" + + age_is_obfuscated: + $ref: + - "_terms.yaml#/age_is_obfuscated/common" + type: boolean + + cause_of_death: + $ref: + - "_terms.yaml#/cause_of_death/common" + enum: + - Cancer Related + - Cardiovascular Disorder, NOS + - End-stage Renal Disease + - Infection + - Not Cancer Related + - Renal Disorder, NOS + - Spinal Muscular Atrophy + - Surgical Complications + - Toxicity + - Unknown + - Not Reported + enumDef: + Cancer Related: + $ref: + - "_terms_enum.yaml#/cancer_related/common" + Cardiovascular Disorder, NOS: + $ref: + - "_terms_enum.yaml#/cardiovascular_disorder_nos/common" + End-stage Renal Disease: + $ref: + - "_terms_enum.yaml#/endstage_renal_disease/common" + Infection: + $ref: + - "_terms_enum.yaml#/infection/common" + Not Cancer Related: + $ref: + - "_terms_enum.yaml#/not_cancer_related/common" + Renal Disorder, NOS: + $ref: + - "_terms_enum.yaml#/renal_disorder_nos/common" + Spinal Muscular Atrophy: + $ref: + - "_terms_enum.yaml#/spinal_muscular_atrophy/common" + Surgical Complications: + $ref: + - "_terms_enum.yaml#/surgical_complications/common" + Toxicity: + $ref: + - "_terms_enum.yaml#/toxicity/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + cause_of_death_source: + $ref: + - "_terms.yaml#/cause_of_death_source/common" + enum: + - Autopsy + - Death Certificate + - Medical Record + - Social Security Death Index + - Unknown + - Not Reported + enumDef: + Autopsy: + $ref: + - "_terms_enum.yaml#/autopsy/common" + Death Certificate: + $ref: + - "_terms_enum.yaml#/death_certificate/common" + Medical Record: + $ref: + - "_terms_enum.yaml#/medical_record/common" + Social Security Death Index: + $ref: + - "_terms_enum.yaml#/social_security_death_index/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + country_of_birth: + $ref: + - "_terms.yaml#/country_of_birth/common" + enum: + - Afghanistan + - Albania + - Algeria + - Andorra + - Angola + - Anguilla + - Antigua and Barbuda + - Argentina + - Armenia + - Aruba + - Australia + - Austria + - Azerbaijan + - Bahamas + - Bahrain + - Bangladesh + - Barbados + - Belarus + - Belgium + - Belize + - Benin + - Bermuda + - Bhutan + - Bolivia + - Bosnia and Herzegovina + - Botswana + - Brazil + - Brunei + - Bulgaria + - Burkina Faso + - Burundi + - Cambodia + - Cameroon + - Canada + - Cape Verde + - Cayman Islands + - Central African Republic + - Chad + - Chile + - China + - Colombia + - Comoros + - Congo + - Cook Islands + - Costa Rica + - Cote d'Ivoire + - Croatia + - Cuba + - Curacao + - Cyprus + - Czech Republic (Czechia) + - Democratic Republic of the Congo + - Denmark + - Djibouti + - Dominica + - Dominican Republic + - Ecuador + - Egypt + - El Salvador + - Equatorial Guinea + - Eritrea + - Estonia + - Eswatini + - Ethiopia + - Falkland Islands (Malvinas) + - Faroe Islands + - Federated States of Micronesia + - Fiji + - Finland + - France + - French Guiana + - French Polynesia + - Gabon + - Gambia + - Georgia + - Germany + - Ghana + - Gibraltar + - Greece + - Greenland + - Grenada + - Guadeloupe + - Guam + - Guatemala + - Guernsey + - Guinea + - Guinea-Bissau + - Guyana + - Haiti + - Holy See + - Honduras + - Hong Kong + - Hungary + - Iceland + - India + - Indonesia + - Iran + - Iraq + - Ireland + - Isle of Man + - Israel + - Italy + - Jamaica + - Japan + - Jersey + - Jordan + - Kazakhstan + - Kenya + - Kiribati + - Kosovo + - Kuwait + - Kyrgyzstan + - Laos + - Latvia + - Lebanon + - Lesotho + - Liberia + - Libya + - Liechtenstein + - Lithuania + - Luxembourg + - Macau + - Madagascar + - Malawi + - Malaysia + - Maldives + - Mali + - Malta + - Marshall Islands + - Martinique + - Mauritania + - Mauritius + - Mayotte + - Mexico + - Moldova + - Monaco + - Mongolia + - Montenegro + - Montserrat + - Morocco + - Mozambique + - Myanmar + - Namibia + - Nauru + - Nepal + - Netherlands + - New Caledonia + - New Zealand + - Nicaragua + - Niger + - Nigeria + - Niue + - North Korea + - North Macedonia + - Northern Mariana Islands + - Norway + - Oman + - Pakistan + - Palau + - Panama + - Papua New Guinea + - Paraguay + - Peru + - Philippines + - Poland + - Portugal + - Puerto Rico + - Qatar + - Reunion + - Romania + - Russia + - Rwanda + - Saint Helena, Ascension and Tristan da Cunha + - Saint Kitts and Nevis + - Saint Lucia + - Saint Pierre and Miquelon + - Saint Vincent and the Grenadines + - Samoa + - San Marino + - Sao Tome and Principe + - Saudi Arabia + - Senegal + - Serbia + - Seychelles + - Sierra Leone + - Singapore + - Slovakia + - Slovenia + - Solomon Islands + - Somalia + - South Africa + - South Korea + - South Sudan + - Spain + - Sri Lanka + - State of Palestine + - Sudan + - Suriname + - Svalbard & Jan Mayen Islands + - Sweden + - Switzerland + - Syria + - Taiwan + - Tajikistan + - Tanzania + - Thailand + - Timor-Leste + - Togo + - Tokelau + - Tonga + - Trinidad and Tobago + - Tunisia + - Turkey + - Turkmenistan + - Tuvalu + - Uganda + - Ukraine + - United Arab Emirates + - United Kingdom + - United States + - Uruguay + - Uzbekistan + - Vanuatu + - Venezuela + - Vietnam + - Virgin Islands, British + - Virgin Islands, U.S. + - Wallis and Futuna + - Western Sahara + - Yemen + - Zambia + - Zimbabwe + - Unknown + - Not Reported + enumDef: + Afghanistan: + $ref: + - "_terms_enum.yaml#/afghanistan/common" + Albania: + $ref: + - "_terms_enum.yaml#/albania/common" + Algeria: + $ref: + - "_terms_enum.yaml#/algeria/common" + Andorra: + $ref: + - "_terms_enum.yaml#/andorra/common" + Angola: + $ref: + - "_terms_enum.yaml#/angola/common" + Anguilla: + $ref: + - "_terms_enum.yaml#/anguilla/common" + Antigua and Barbuda: + $ref: + - "_terms_enum.yaml#/antigua_and_barbuda/common" + Argentina: + $ref: + - "_terms_enum.yaml#/argentina/common" + Armenia: + $ref: + - "_terms_enum.yaml#/armenia/common" + Aruba: + $ref: + - "_terms_enum.yaml#/aruba/common" + Australia: + $ref: + - "_terms_enum.yaml#/australia/common" + Austria: + $ref: + - "_terms_enum.yaml#/austria/common" + Azerbaijan: + $ref: + - "_terms_enum.yaml#/azerbaijan/common" + Bahamas: + $ref: + - "_terms_enum.yaml#/bahamas/common" + Bahrain: + $ref: + - "_terms_enum.yaml#/bahrain/common" + Bangladesh: + $ref: + - "_terms_enum.yaml#/bangladesh/common" + Barbados: + $ref: + - "_terms_enum.yaml#/barbados/common" + Belarus: + $ref: + - "_terms_enum.yaml#/belarus/common" + Belgium: + $ref: + - "_terms_enum.yaml#/belgium/common" + Belize: + $ref: + - "_terms_enum.yaml#/belize/common" + Benin: + $ref: + - "_terms_enum.yaml#/benin/common" + Bermuda: + $ref: + - "_terms_enum.yaml#/bermuda/common" + Bhutan: + $ref: + - "_terms_enum.yaml#/bhutan/common" + Bolivia: + $ref: + - "_terms_enum.yaml#/bolivia/common" + Bosnia and Herzegovina: + $ref: + - "_terms_enum.yaml#/bosnia_and_herzegovina/common" + Botswana: + $ref: + - "_terms_enum.yaml#/botswana/common" + Brazil: + $ref: + - "_terms_enum.yaml#/brazil/common" + Brunei: + $ref: + - "_terms_enum.yaml#/brunei/common" + Bulgaria: + $ref: + - "_terms_enum.yaml#/bulgaria/common" + Burkina Faso: + $ref: + - "_terms_enum.yaml#/burkina_faso/common" + Burundi: + $ref: + - "_terms_enum.yaml#/burundi/common" + Cambodia: + $ref: + - "_terms_enum.yaml#/cambodia/common" + Cameroon: + $ref: + - "_terms_enum.yaml#/cameroon/common" + Canada: + $ref: + - "_terms_enum.yaml#/canada/common" + Cape Verde: + $ref: + - "_terms_enum.yaml#/cape_verde/common" + Cayman Islands: + $ref: + - "_terms_enum.yaml#/cayman_islands/common" + Central African Republic: + $ref: + - "_terms_enum.yaml#/central_african_republic/common" + Chad: + $ref: + - "_terms_enum.yaml#/chad/common" + Chile: + $ref: + - "_terms_enum.yaml#/chile/common" + China: + $ref: + - "_terms_enum.yaml#/china/common" + Colombia: + $ref: + - "_terms_enum.yaml#/colombia/common" + Comoros: + $ref: + - "_terms_enum.yaml#/comoros/common" + Congo: + $ref: + - "_terms_enum.yaml#/congo/common" + Cook Islands: + $ref: + - "_terms_enum.yaml#/cook_islands/common" + Costa Rica: + $ref: + - "_terms_enum.yaml#/costa_rica/common" + Cote d'Ivoire: + $ref: + - "_terms_enum.yaml#/cote_divoire/common" + Croatia: + $ref: + - "_terms_enum.yaml#/croatia/common" + Cuba: + $ref: + - "_terms_enum.yaml#/cuba/common" + Curacao: + $ref: + - "_terms_enum.yaml#/curacao/common" + Cyprus: + $ref: + - "_terms_enum.yaml#/cyprus/common" + Czech Republic (Czechia): + $ref: + - "_terms_enum.yaml#/czech_republic_czechia/common" + Democratic Republic of the Congo: + $ref: + - "_terms_enum.yaml#/democratic_republic_of_the_congo/common" + Denmark: + $ref: + - "_terms_enum.yaml#/denmark/common" + Djibouti: + $ref: + - "_terms_enum.yaml#/djibouti/common" + Dominica: + $ref: + - "_terms_enum.yaml#/dominica/common" + Dominican Republic: + $ref: + - "_terms_enum.yaml#/dominican_republic/common" + Ecuador: + $ref: + - "_terms_enum.yaml#/ecuador/common" + Egypt: + $ref: + - "_terms_enum.yaml#/egypt/common" + El Salvador: + $ref: + - "_terms_enum.yaml#/el_salvador/common" + Equatorial Guinea: + $ref: + - "_terms_enum.yaml#/equatorial_guinea/common" + Eritrea: + $ref: + - "_terms_enum.yaml#/eritrea/common" + Estonia: + $ref: + - "_terms_enum.yaml#/estonia/common" + Eswatini: + $ref: + - "_terms_enum.yaml#/eswatini/common" + Ethiopia: + $ref: + - "_terms_enum.yaml#/ethiopia/common" + Falkland Islands (Malvinas): + $ref: + - "_terms_enum.yaml#/falkland_islands_malvinas/common" + Faroe Islands: + $ref: + - "_terms_enum.yaml#/faroe_islands/common" + Federated States of Micronesia: + $ref: + - "_terms_enum.yaml#/federated_states_of_micronesia/common" + Fiji: + $ref: + - "_terms_enum.yaml#/fiji/common" + Finland: + $ref: + - "_terms_enum.yaml#/finland/common" + France: + $ref: + - "_terms_enum.yaml#/france/common" + French Guiana: + $ref: + - "_terms_enum.yaml#/french_guiana/common" + French Polynesia: + $ref: + - "_terms_enum.yaml#/french_polynesia/common" + Gabon: + $ref: + - "_terms_enum.yaml#/gabon/common" + Gambia: + $ref: + - "_terms_enum.yaml#/gambia/common" + Georgia: + $ref: + - "_terms_enum.yaml#/georgia/common" + Germany: + $ref: + - "_terms_enum.yaml#/germany/common" + Ghana: + $ref: + - "_terms_enum.yaml#/ghana/common" + Gibraltar: + $ref: + - "_terms_enum.yaml#/gibraltar/common" + Greece: + $ref: + - "_terms_enum.yaml#/greece/common" + Greenland: + $ref: + - "_terms_enum.yaml#/greenland/common" + Grenada: + $ref: + - "_terms_enum.yaml#/grenada/common" + Guadeloupe: + $ref: + - "_terms_enum.yaml#/guadeloupe/common" + Guam: + $ref: + - "_terms_enum.yaml#/guam/common" + Guatemala: + $ref: + - "_terms_enum.yaml#/guatemala/common" + Guernsey: + $ref: + - "_terms_enum.yaml#/guernsey/common" + Guinea: + $ref: + - "_terms_enum.yaml#/guinea/common" + Guinea-Bissau: + $ref: + - "_terms_enum.yaml#/guineabissau/common" + Guyana: + $ref: + - "_terms_enum.yaml#/guyana/common" + Haiti: + $ref: + - "_terms_enum.yaml#/haiti/common" + Holy See: + $ref: + - "_terms_enum.yaml#/holy_see/common" + Honduras: + $ref: + - "_terms_enum.yaml#/honduras/common" + Hong Kong: + $ref: + - "_terms_enum.yaml#/hong_kong/common" + Hungary: + $ref: + - "_terms_enum.yaml#/hungary/common" + Iceland: + $ref: + - "_terms_enum.yaml#/iceland/common" + India: + $ref: + - "_terms_enum.yaml#/india/common" + Indonesia: + $ref: + - "_terms_enum.yaml#/indonesia/common" + Iran: + $ref: + - "_terms_enum.yaml#/iran/common" + Iraq: + $ref: + - "_terms_enum.yaml#/iraq/common" + Ireland: + $ref: + - "_terms_enum.yaml#/ireland/common" + Isle of Man: + $ref: + - "_terms_enum.yaml#/isle_of_man/common" + Israel: + $ref: + - "_terms_enum.yaml#/israel/common" + Italy: + $ref: + - "_terms_enum.yaml#/italy/common" + Jamaica: + $ref: + - "_terms_enum.yaml#/jamaica/common" + Japan: + $ref: + - "_terms_enum.yaml#/japan/common" + Jersey: + $ref: + - "_terms_enum.yaml#/jersey/common" + Jordan: + $ref: + - "_terms_enum.yaml#/jordan/common" + Kazakhstan: + $ref: + - "_terms_enum.yaml#/kazakhstan/common" + Kenya: + $ref: + - "_terms_enum.yaml#/kenya/common" + Kiribati: + $ref: + - "_terms_enum.yaml#/kiribati/common" + Kosovo: + $ref: + - "_terms_enum.yaml#/kosovo/common" + Kuwait: + $ref: + - "_terms_enum.yaml#/kuwait/common" + Kyrgyzstan: + $ref: + - "_terms_enum.yaml#/kyrgyzstan/common" + Laos: + $ref: + - "_terms_enum.yaml#/laos/common" + Latvia: + $ref: + - "_terms_enum.yaml#/latvia/common" + Lebanon: + $ref: + - "_terms_enum.yaml#/lebanon/common" + Lesotho: + $ref: + - "_terms_enum.yaml#/lesotho/common" + Liberia: + $ref: + - "_terms_enum.yaml#/liberia/common" + Libya: + $ref: + - "_terms_enum.yaml#/libya/common" + Liechtenstein: + $ref: + - "_terms_enum.yaml#/liechtenstein/common" + Lithuania: + $ref: + - "_terms_enum.yaml#/lithuania/common" + Luxembourg: + $ref: + - "_terms_enum.yaml#/luxembourg/common" + Macau: + $ref: + - "_terms_enum.yaml#/macau/common" + Madagascar: + $ref: + - "_terms_enum.yaml#/madagascar/common" + Malawi: + $ref: + - "_terms_enum.yaml#/malawi/common" + Malaysia: + $ref: + - "_terms_enum.yaml#/malaysia/common" + Maldives: + $ref: + - "_terms_enum.yaml#/maldives/common" + Mali: + $ref: + - "_terms_enum.yaml#/mali/common" + Malta: + $ref: + - "_terms_enum.yaml#/malta/common" + Marshall Islands: + $ref: + - "_terms_enum.yaml#/marshall_islands/common" + Martinique: + $ref: + - "_terms_enum.yaml#/martinique/common" + Mauritania: + $ref: + - "_terms_enum.yaml#/mauritania/common" + Mauritius: + $ref: + - "_terms_enum.yaml#/mauritius/common" + Mayotte: + $ref: + - "_terms_enum.yaml#/mayotte/common" + Mexico: + $ref: + - "_terms_enum.yaml#/mexico/common" + Moldova: + $ref: + - "_terms_enum.yaml#/moldova/common" + Monaco: + $ref: + - "_terms_enum.yaml#/monaco/common" + Mongolia: + $ref: + - "_terms_enum.yaml#/mongolia/common" + Montenegro: + $ref: + - "_terms_enum.yaml#/montenegro/common" + Montserrat: + $ref: + - "_terms_enum.yaml#/montserrat/common" + Morocco: + $ref: + - "_terms_enum.yaml#/morocco/common" + Mozambique: + $ref: + - "_terms_enum.yaml#/mozambique/common" + Myanmar: + $ref: + - "_terms_enum.yaml#/myanmar/common" + Namibia: + $ref: + - "_terms_enum.yaml#/namibia/common" + Nauru: + $ref: + - "_terms_enum.yaml#/nauru/common" + Nepal: + $ref: + - "_terms_enum.yaml#/nepal/common" + Netherlands: + $ref: + - "_terms_enum.yaml#/netherlands/common" + New Caledonia: + $ref: + - "_terms_enum.yaml#/new_caledonia/common" + New Zealand: + $ref: + - "_terms_enum.yaml#/new_zealand/common" + Nicaragua: + $ref: + - "_terms_enum.yaml#/nicaragua/common" + Niger: + $ref: + - "_terms_enum.yaml#/niger/common" + Nigeria: + $ref: + - "_terms_enum.yaml#/nigeria/common" + Niue: + $ref: + - "_terms_enum.yaml#/niue/common" + North Korea: + $ref: + - "_terms_enum.yaml#/north_korea/common" + North Macedonia: + $ref: + - "_terms_enum.yaml#/north_macedonia/common" + Northern Mariana Islands: + $ref: + - "_terms_enum.yaml#/northern_mariana_islands/common" + Norway: + $ref: + - "_terms_enum.yaml#/norway/common" + Oman: + $ref: + - "_terms_enum.yaml#/oman/common" + Pakistan: + $ref: + - "_terms_enum.yaml#/pakistan/common" + Palau: + $ref: + - "_terms_enum.yaml#/palau/common" + Panama: + $ref: + - "_terms_enum.yaml#/panama/common" + Papua New Guinea: + $ref: + - "_terms_enum.yaml#/papua_new_guinea/common" + Paraguay: + $ref: + - "_terms_enum.yaml#/paraguay/common" + Peru: + $ref: + - "_terms_enum.yaml#/peru/common" + Philippines: + $ref: + - "_terms_enum.yaml#/philippines/common" + Poland: + $ref: + - "_terms_enum.yaml#/poland/common" + Portugal: + $ref: + - "_terms_enum.yaml#/portugal/common" + Puerto Rico: + $ref: + - "_terms_enum.yaml#/puerto_rico/common" + Qatar: + $ref: + - "_terms_enum.yaml#/qatar/common" + Reunion: + $ref: + - "_terms_enum.yaml#/reunion/common" + Romania: + $ref: + - "_terms_enum.yaml#/romania/common" + Russia: + $ref: + - "_terms_enum.yaml#/russia/common" + Rwanda: + $ref: + - "_terms_enum.yaml#/rwanda/common" + Saint Helena, Ascension and Tristan da Cunha: + $ref: + - "_terms_enum.yaml#/saint_helena_ascension_and_tristan_da_cunha/common" + Saint Kitts and Nevis: + $ref: + - "_terms_enum.yaml#/saint_kitts_and_nevis/common" + Saint Lucia: + $ref: + - "_terms_enum.yaml#/saint_lucia/common" + Saint Pierre and Miquelon: + $ref: + - "_terms_enum.yaml#/saint_pierre_and_miquelon/common" + Saint Vincent and the Grenadines: + $ref: + - "_terms_enum.yaml#/saint_vincent_and_the_grenadines/common" + Samoa: + $ref: + - "_terms_enum.yaml#/samoa/common" + San Marino: + $ref: + - "_terms_enum.yaml#/san_marino/common" + Sao Tome and Principe: + $ref: + - "_terms_enum.yaml#/sao_tome_and_principe/common" + Saudi Arabia: + $ref: + - "_terms_enum.yaml#/saudi_arabia/common" + Senegal: + $ref: + - "_terms_enum.yaml#/senegal/common" + Serbia: + $ref: + - "_terms_enum.yaml#/serbia/common" + Seychelles: + $ref: + - "_terms_enum.yaml#/seychelles/common" + Sierra Leone: + $ref: + - "_terms_enum.yaml#/sierra_leone/common" + Singapore: + $ref: + - "_terms_enum.yaml#/singapore/common" + Slovakia: + $ref: + - "_terms_enum.yaml#/slovakia/common" + Slovenia: + $ref: + - "_terms_enum.yaml#/slovenia/common" + Solomon Islands: + $ref: + - "_terms_enum.yaml#/solomon_islands/common" + Somalia: + $ref: + - "_terms_enum.yaml#/somalia/common" + South Africa: + $ref: + - "_terms_enum.yaml#/south_africa/common" + South Korea: + $ref: + - "_terms_enum.yaml#/south_korea/common" + South Sudan: + $ref: + - "_terms_enum.yaml#/south_sudan/common" + Spain: + $ref: + - "_terms_enum.yaml#/spain/common" + Sri Lanka: + $ref: + - "_terms_enum.yaml#/sri_lanka/common" + State of Palestine: + $ref: + - "_terms_enum.yaml#/state_of_palestine/common" + Sudan: + $ref: + - "_terms_enum.yaml#/sudan/common" + Suriname: + $ref: + - "_terms_enum.yaml#/suriname/common" + Svalbard & Jan Mayen Islands: + $ref: + - "_terms_enum.yaml#/svalbard__jan_mayen_islands/common" + Sweden: + $ref: + - "_terms_enum.yaml#/sweden/common" + Switzerland: + $ref: + - "_terms_enum.yaml#/switzerland/common" + Syria: + $ref: + - "_terms_enum.yaml#/syria/common" + Taiwan: + $ref: + - "_terms_enum.yaml#/taiwan/common" + Tajikistan: + $ref: + - "_terms_enum.yaml#/tajikistan/common" + Tanzania: + $ref: + - "_terms_enum.yaml#/tanzania/common" + Thailand: + $ref: + - "_terms_enum.yaml#/thailand/common" + Timor-Leste: + $ref: + - "_terms_enum.yaml#/timorleste/common" + Togo: + $ref: + - "_terms_enum.yaml#/togo/common" + Tokelau: + $ref: + - "_terms_enum.yaml#/tokelau/common" + Tonga: + $ref: + - "_terms_enum.yaml#/tonga/common" + Trinidad and Tobago: + $ref: + - "_terms_enum.yaml#/trinidad_and_tobago/common" + Tunisia: + $ref: + - "_terms_enum.yaml#/tunisia/common" + Turkey: + $ref: + - "_terms_enum.yaml#/turkey/common" + Turkmenistan: + $ref: + - "_terms_enum.yaml#/turkmenistan/common" + Tuvalu: + $ref: + - "_terms_enum.yaml#/tuvalu/common" + Uganda: + $ref: + - "_terms_enum.yaml#/uganda/common" + Ukraine: + $ref: + - "_terms_enum.yaml#/ukraine/common" + United Arab Emirates: + $ref: + - "_terms_enum.yaml#/united_arab_emirates/common" + United Kingdom: + $ref: + - "_terms_enum.yaml#/united_kingdom/common" + United States: + $ref: + - "_terms_enum.yaml#/united_states/common" + Uruguay: + $ref: + - "_terms_enum.yaml#/uruguay/common" + Uzbekistan: + $ref: + - "_terms_enum.yaml#/uzbekistan/common" + Vanuatu: + $ref: + - "_terms_enum.yaml#/vanuatu/common" + Venezuela: + $ref: + - "_terms_enum.yaml#/venezuela/common" + Vietnam: + $ref: + - "_terms_enum.yaml#/vietnam/common" + Virgin Islands, British: + $ref: + - "_terms_enum.yaml#/virgin_islands_british/common" + Virgin Islands, U.S.: + $ref: + - "_terms_enum.yaml#/virgin_islands_us/common" + Wallis and Futuna: + $ref: + - "_terms_enum.yaml#/wallis_and_futuna/common" + Western Sahara: + $ref: + - "_terms_enum.yaml#/western_sahara/common" + Yemen: + $ref: + - "_terms_enum.yaml#/yemen/common" + Zambia: + $ref: + - "_terms_enum.yaml#/zambia/common" + Zimbabwe: + $ref: + - "_terms_enum.yaml#/zimbabwe/common" + + country_of_residence_at_enrollment: + $ref: + - "_terms.yaml#/country_of_residence_at_enrollment/common" + enum: + - Afghanistan + - Albania + - Algeria + - Andorra + - Angola + - Anguilla + - Antigua and Barbuda + - Argentina + - Armenia + - Aruba + - Australia + - Austria + - Azerbaijan + - Bahamas + - Bahrain + - Bangladesh + - Barbados + - Belarus + - Belgium + - Belize + - Benin + - Bermuda + - Bhutan + - Bolivia + - Bosnia and Herzegovina + - Botswana + - Brazil + - Brunei + - Bulgaria + - Burkina Faso + - Burundi + - Cambodia + - Cameroon + - Canada + - Cape Verde + - Cayman Islands + - Central African Republic + - Chad + - Chile + - China + - Colombia + - Comoros + - Congo + - Cook Islands + - Costa Rica + - Cote d'Ivoire + - Croatia + - Cuba + - Curacao + - Cyprus + - Czech Republic (Czechia) + - Democratic Republic of the Congo + - Denmark + - Djibouti + - Dominica + - Dominican Republic + - Ecuador + - Egypt + - El Salvador + - Equatorial Guinea + - Eritrea + - Estonia + - Eswatini + - Ethiopia + - Falkland Islands (Malvinas) + - Faroe Islands + - Federated States of Micronesia + - Fiji + - Finland + - France + - French Guiana + - French Polynesia + - Gabon + - Gambia + - Georgia + - Germany + - Ghana + - Gibraltar + - Greece + - Greenland + - Grenada + - Guadeloupe + - Guam + - Guatemala + - Guernsey + - Guinea + - Guinea-Bissau + - Guyana + - Haiti + - Holy See + - Honduras + - Hong Kong + - Hungary + - Iceland + - India + - Indonesia + - Iran + - Iraq + - Ireland + - Isle of Man + - Israel + - Italy + - Jamaica + - Japan + - Jersey + - Jordan + - Kazakhstan + - Kenya + - Kiribati + - Kosovo + - Kuwait + - Kyrgyzstan + - Laos + - Latvia + - Lebanon + - Lesotho + - Liberia + - Libya + - Liechtenstein + - Lithuania + - Luxembourg + - Macau + - Madagascar + - Malawi + - Malaysia + - Maldives + - Mali + - Malta + - Marshall Islands + - Martinique + - Mauritania + - Mauritius + - Mayotte + - Mexico + - Moldova + - Monaco + - Mongolia + - Montenegro + - Montserrat + - Morocco + - Mozambique + - Myanmar + - Namibia + - Nauru + - Nepal + - Netherlands + - New Caledonia + - New Zealand + - Nicaragua + - Niger + - Nigeria + - Niue + - North Korea + - North Macedonia + - Northern Mariana Islands + - Norway + - Oman + - Pakistan + - Palau + - Panama + - Papua New Guinea + - Paraguay + - Peru + - Philippines + - Poland + - Portugal + - Puerto Rico + - Qatar + - Reunion + - Romania + - Russia + - Rwanda + - Saint Helena, Ascension and Tristan da Cunha + - Saint Kitts and Nevis + - Saint Lucia + - Saint Pierre and Miquelon + - Saint Vincent and the Grenadines + - Samoa + - San Marino + - Sao Tome and Principe + - Saudi Arabia + - Senegal + - Serbia + - Seychelles + - Sierra Leone + - Singapore + - Slovakia + - Slovenia + - Solomon Islands + - Somalia + - South Africa + - South Korea + - South Sudan + - Spain + - Sri Lanka + - State of Palestine + - Sudan + - Suriname + - Svalbard & Jan Mayen Islands + - Sweden + - Switzerland + - Syria + - Taiwan + - Tajikistan + - Tanzania + - Thailand + - Timor-Leste + - Togo + - Tokelau + - Tonga + - Trinidad and Tobago + - Tunisia + - Turkey + - Turkmenistan + - Tuvalu + - Uganda + - Ukraine + - United Arab Emirates + - United Kingdom + - United States + - Uruguay + - Uzbekistan + - Vanuatu + - Venezuela + - Vietnam + - Virgin Islands, British + - Virgin Islands, U.S. + - Wallis and Futuna + - Western Sahara + - Yemen + - Zambia + - Zimbabwe + - Unknown + - Not Reported + enumDef: + Afghanistan: + $ref: + - "_terms_enum.yaml#/afghanistan/common" + Albania: + $ref: + - "_terms_enum.yaml#/albania/common" + Algeria: + $ref: + - "_terms_enum.yaml#/algeria/common" + Andorra: + $ref: + - "_terms_enum.yaml#/andorra/common" + Angola: + $ref: + - "_terms_enum.yaml#/angola/common" + Anguilla: + $ref: + - "_terms_enum.yaml#/anguilla/common" + Antigua and Barbuda: + $ref: + - "_terms_enum.yaml#/antigua_and_barbuda/common" + Argentina: + $ref: + - "_terms_enum.yaml#/argentina/common" + Armenia: + $ref: + - "_terms_enum.yaml#/armenia/common" + Aruba: + $ref: + - "_terms_enum.yaml#/aruba/common" + Australia: + $ref: + - "_terms_enum.yaml#/australia/common" + Austria: + $ref: + - "_terms_enum.yaml#/austria/common" + Azerbaijan: + $ref: + - "_terms_enum.yaml#/azerbaijan/common" + Bahamas: + $ref: + - "_terms_enum.yaml#/bahamas/common" + Bahrain: + $ref: + - "_terms_enum.yaml#/bahrain/common" + Bangladesh: + $ref: + - "_terms_enum.yaml#/bangladesh/common" + Barbados: + $ref: + - "_terms_enum.yaml#/barbados/common" + Belarus: + $ref: + - "_terms_enum.yaml#/belarus/common" + Belgium: + $ref: + - "_terms_enum.yaml#/belgium/common" + Belize: + $ref: + - "_terms_enum.yaml#/belize/common" + Benin: + $ref: + - "_terms_enum.yaml#/benin/common" + Bermuda: + $ref: + - "_terms_enum.yaml#/bermuda/common" + Bhutan: + $ref: + - "_terms_enum.yaml#/bhutan/common" + Bolivia: + $ref: + - "_terms_enum.yaml#/bolivia/common" + Bosnia and Herzegovina: + $ref: + - "_terms_enum.yaml#/bosnia_and_herzegovina/common" + Botswana: + $ref: + - "_terms_enum.yaml#/botswana/common" + Brazil: + $ref: + - "_terms_enum.yaml#/brazil/common" + Brunei: + $ref: + - "_terms_enum.yaml#/brunei/common" + Bulgaria: + $ref: + - "_terms_enum.yaml#/bulgaria/common" + Burkina Faso: + $ref: + - "_terms_enum.yaml#/burkina_faso/common" + Burundi: + $ref: + - "_terms_enum.yaml#/burundi/common" + Cambodia: + $ref: + - "_terms_enum.yaml#/cambodia/common" + Cameroon: + $ref: + - "_terms_enum.yaml#/cameroon/common" + Canada: + $ref: + - "_terms_enum.yaml#/canada/common" + Cape Verde: + $ref: + - "_terms_enum.yaml#/cape_verde/common" + Cayman Islands: + $ref: + - "_terms_enum.yaml#/cayman_islands/common" + Central African Republic: + $ref: + - "_terms_enum.yaml#/central_african_republic/common" + Chad: + $ref: + - "_terms_enum.yaml#/chad/common" + Chile: + $ref: + - "_terms_enum.yaml#/chile/common" + China: + $ref: + - "_terms_enum.yaml#/china/common" + Colombia: + $ref: + - "_terms_enum.yaml#/colombia/common" + Comoros: + $ref: + - "_terms_enum.yaml#/comoros/common" + Congo: + $ref: + - "_terms_enum.yaml#/congo/common" + Cook Islands: + $ref: + - "_terms_enum.yaml#/cook_islands/common" + Costa Rica: + $ref: + - "_terms_enum.yaml#/costa_rica/common" + Cote d'Ivoire: + $ref: + - "_terms_enum.yaml#/cote_divoire/common" + Croatia: + $ref: + - "_terms_enum.yaml#/croatia/common" + Cuba: + $ref: + - "_terms_enum.yaml#/cuba/common" + Curacao: + $ref: + - "_terms_enum.yaml#/curacao/common" + Cyprus: + $ref: + - "_terms_enum.yaml#/cyprus/common" + Czech Republic (Czechia): + $ref: + - "_terms_enum.yaml#/czech_republic_czechia/common" + Democratic Republic of the Congo: + $ref: + - "_terms_enum.yaml#/democratic_republic_of_the_congo/common" + Denmark: + $ref: + - "_terms_enum.yaml#/denmark/common" + Djibouti: + $ref: + - "_terms_enum.yaml#/djibouti/common" + Dominica: + $ref: + - "_terms_enum.yaml#/dominica/common" + Dominican Republic: + $ref: + - "_terms_enum.yaml#/dominican_republic/common" + Ecuador: + $ref: + - "_terms_enum.yaml#/ecuador/common" + Egypt: + $ref: + - "_terms_enum.yaml#/egypt/common" + El Salvador: + $ref: + - "_terms_enum.yaml#/el_salvador/common" + Equatorial Guinea: + $ref: + - "_terms_enum.yaml#/equatorial_guinea/common" + Eritrea: + $ref: + - "_terms_enum.yaml#/eritrea/common" + Estonia: + $ref: + - "_terms_enum.yaml#/estonia/common" + Eswatini: + $ref: + - "_terms_enum.yaml#/eswatini/common" + Ethiopia: + $ref: + - "_terms_enum.yaml#/ethiopia/common" + Falkland Islands (Malvinas): + $ref: + - "_terms_enum.yaml#/falkland_islands_malvinas/common" + Faroe Islands: + $ref: + - "_terms_enum.yaml#/faroe_islands/common" + Federated States of Micronesia: + $ref: + - "_terms_enum.yaml#/federated_states_of_micronesia/common" + Fiji: + $ref: + - "_terms_enum.yaml#/fiji/common" + Finland: + $ref: + - "_terms_enum.yaml#/finland/common" + France: + $ref: + - "_terms_enum.yaml#/france/common" + French Guiana: + $ref: + - "_terms_enum.yaml#/french_guiana/common" + French Polynesia: + $ref: + - "_terms_enum.yaml#/french_polynesia/common" + Gabon: + $ref: + - "_terms_enum.yaml#/gabon/common" + Gambia: + $ref: + - "_terms_enum.yaml#/gambia/common" + Georgia: + $ref: + - "_terms_enum.yaml#/georgia/common" + Germany: + $ref: + - "_terms_enum.yaml#/germany/common" + Ghana: + $ref: + - "_terms_enum.yaml#/ghana/common" + Gibraltar: + $ref: + - "_terms_enum.yaml#/gibraltar/common" + Greece: + $ref: + - "_terms_enum.yaml#/greece/common" + Greenland: + $ref: + - "_terms_enum.yaml#/greenland/common" + Grenada: + $ref: + - "_terms_enum.yaml#/grenada/common" + Guadeloupe: + $ref: + - "_terms_enum.yaml#/guadeloupe/common" + Guam: + $ref: + - "_terms_enum.yaml#/guam/common" + Guatemala: + $ref: + - "_terms_enum.yaml#/guatemala/common" + Guernsey: + $ref: + - "_terms_enum.yaml#/guernsey/common" + Guinea: + $ref: + - "_terms_enum.yaml#/guinea/common" + Guinea-Bissau: + $ref: + - "_terms_enum.yaml#/guineabissau/common" + Guyana: + $ref: + - "_terms_enum.yaml#/guyana/common" + Haiti: + $ref: + - "_terms_enum.yaml#/haiti/common" + Holy See: + $ref: + - "_terms_enum.yaml#/holy_see/common" + Honduras: + $ref: + - "_terms_enum.yaml#/honduras/common" + Hong Kong: + $ref: + - "_terms_enum.yaml#/hong_kong/common" + Hungary: + $ref: + - "_terms_enum.yaml#/hungary/common" + Iceland: + $ref: + - "_terms_enum.yaml#/iceland/common" + India: + $ref: + - "_terms_enum.yaml#/india/common" + Indonesia: + $ref: + - "_terms_enum.yaml#/indonesia/common" + Iran: + $ref: + - "_terms_enum.yaml#/iran/common" + Iraq: + $ref: + - "_terms_enum.yaml#/iraq/common" + Ireland: + $ref: + - "_terms_enum.yaml#/ireland/common" + Isle of Man: + $ref: + - "_terms_enum.yaml#/isle_of_man/common" + Israel: + $ref: + - "_terms_enum.yaml#/israel/common" + Italy: + $ref: + - "_terms_enum.yaml#/italy/common" + Jamaica: + $ref: + - "_terms_enum.yaml#/jamaica/common" + Japan: + $ref: + - "_terms_enum.yaml#/japan/common" + Jersey: + $ref: + - "_terms_enum.yaml#/jersey/common" + Jordan: + $ref: + - "_terms_enum.yaml#/jordan/common" + Kazakhstan: + $ref: + - "_terms_enum.yaml#/kazakhstan/common" + Kenya: + $ref: + - "_terms_enum.yaml#/kenya/common" + Kiribati: + $ref: + - "_terms_enum.yaml#/kiribati/common" + Kosovo: + $ref: + - "_terms_enum.yaml#/kosovo/common" + Kuwait: + $ref: + - "_terms_enum.yaml#/kuwait/common" + Kyrgyzstan: + $ref: + - "_terms_enum.yaml#/kyrgyzstan/common" + Laos: + $ref: + - "_terms_enum.yaml#/laos/common" + Latvia: + $ref: + - "_terms_enum.yaml#/latvia/common" + Lebanon: + $ref: + - "_terms_enum.yaml#/lebanon/common" + Lesotho: + $ref: + - "_terms_enum.yaml#/lesotho/common" + Liberia: + $ref: + - "_terms_enum.yaml#/liberia/common" + Libya: + $ref: + - "_terms_enum.yaml#/libya/common" + Liechtenstein: + $ref: + - "_terms_enum.yaml#/liechtenstein/common" + Lithuania: + $ref: + - "_terms_enum.yaml#/lithuania/common" + Luxembourg: + $ref: + - "_terms_enum.yaml#/luxembourg/common" + Macau: + $ref: + - "_terms_enum.yaml#/macau/common" + Madagascar: + $ref: + - "_terms_enum.yaml#/madagascar/common" + Malawi: + $ref: + - "_terms_enum.yaml#/malawi/common" + Malaysia: + $ref: + - "_terms_enum.yaml#/malaysia/common" + Maldives: + $ref: + - "_terms_enum.yaml#/maldives/common" + Mali: + $ref: + - "_terms_enum.yaml#/mali/common" + Malta: + $ref: + - "_terms_enum.yaml#/malta/common" + Marshall Islands: + $ref: + - "_terms_enum.yaml#/marshall_islands/common" + Martinique: + $ref: + - "_terms_enum.yaml#/martinique/common" + Mauritania: + $ref: + - "_terms_enum.yaml#/mauritania/common" + Mauritius: + $ref: + - "_terms_enum.yaml#/mauritius/common" + Mayotte: + $ref: + - "_terms_enum.yaml#/mayotte/common" + Mexico: + $ref: + - "_terms_enum.yaml#/mexico/common" + Moldova: + $ref: + - "_terms_enum.yaml#/moldova/common" + Monaco: + $ref: + - "_terms_enum.yaml#/monaco/common" + Mongolia: + $ref: + - "_terms_enum.yaml#/mongolia/common" + Montenegro: + $ref: + - "_terms_enum.yaml#/montenegro/common" + Montserrat: + $ref: + - "_terms_enum.yaml#/montserrat/common" + Morocco: + $ref: + - "_terms_enum.yaml#/morocco/common" + Mozambique: + $ref: + - "_terms_enum.yaml#/mozambique/common" + Myanmar: + $ref: + - "_terms_enum.yaml#/myanmar/common" + Namibia: + $ref: + - "_terms_enum.yaml#/namibia/common" + Nauru: + $ref: + - "_terms_enum.yaml#/nauru/common" + Nepal: + $ref: + - "_terms_enum.yaml#/nepal/common" + Netherlands: + $ref: + - "_terms_enum.yaml#/netherlands/common" + New Caledonia: + $ref: + - "_terms_enum.yaml#/new_caledonia/common" + New Zealand: + $ref: + - "_terms_enum.yaml#/new_zealand/common" + Nicaragua: + $ref: + - "_terms_enum.yaml#/nicaragua/common" + Niger: + $ref: + - "_terms_enum.yaml#/niger/common" + Nigeria: + $ref: + - "_terms_enum.yaml#/nigeria/common" + Niue: + $ref: + - "_terms_enum.yaml#/niue/common" + North Korea: + $ref: + - "_terms_enum.yaml#/north_korea/common" + North Macedonia: + $ref: + - "_terms_enum.yaml#/north_macedonia/common" + Northern Mariana Islands: + $ref: + - "_terms_enum.yaml#/northern_mariana_islands/common" + Norway: + $ref: + - "_terms_enum.yaml#/norway/common" + Oman: + $ref: + - "_terms_enum.yaml#/oman/common" + Pakistan: + $ref: + - "_terms_enum.yaml#/pakistan/common" + Palau: + $ref: + - "_terms_enum.yaml#/palau/common" + Panama: + $ref: + - "_terms_enum.yaml#/panama/common" + Papua New Guinea: + $ref: + - "_terms_enum.yaml#/papua_new_guinea/common" + Paraguay: + $ref: + - "_terms_enum.yaml#/paraguay/common" + Peru: + $ref: + - "_terms_enum.yaml#/peru/common" + Philippines: + $ref: + - "_terms_enum.yaml#/philippines/common" + Poland: + $ref: + - "_terms_enum.yaml#/poland/common" + Portugal: + $ref: + - "_terms_enum.yaml#/portugal/common" + Puerto Rico: + $ref: + - "_terms_enum.yaml#/puerto_rico/common" + Qatar: + $ref: + - "_terms_enum.yaml#/qatar/common" + Reunion: + $ref: + - "_terms_enum.yaml#/reunion/common" + Romania: + $ref: + - "_terms_enum.yaml#/romania/common" + Russia: + $ref: + - "_terms_enum.yaml#/russia/common" + Rwanda: + $ref: + - "_terms_enum.yaml#/rwanda/common" + Saint Helena, Ascension and Tristan da Cunha: + $ref: + - "_terms_enum.yaml#/saint_helena_ascension_and_tristan_da_cunha/common" + Saint Kitts and Nevis: + $ref: + - "_terms_enum.yaml#/saint_kitts_and_nevis/common" + Saint Lucia: + $ref: + - "_terms_enum.yaml#/saint_lucia/common" + Saint Pierre and Miquelon: + $ref: + - "_terms_enum.yaml#/saint_pierre_and_miquelon/common" + Saint Vincent and the Grenadines: + $ref: + - "_terms_enum.yaml#/saint_vincent_and_the_grenadines/common" + Samoa: + $ref: + - "_terms_enum.yaml#/samoa/common" + San Marino: + $ref: + - "_terms_enum.yaml#/san_marino/common" + Sao Tome and Principe: + $ref: + - "_terms_enum.yaml#/sao_tome_and_principe/common" + Saudi Arabia: + $ref: + - "_terms_enum.yaml#/saudi_arabia/common" + Senegal: + $ref: + - "_terms_enum.yaml#/senegal/common" + Serbia: + $ref: + - "_terms_enum.yaml#/serbia/common" + Seychelles: + $ref: + - "_terms_enum.yaml#/seychelles/common" + Sierra Leone: + $ref: + - "_terms_enum.yaml#/sierra_leone/common" + Singapore: + $ref: + - "_terms_enum.yaml#/singapore/common" + Slovakia: + $ref: + - "_terms_enum.yaml#/slovakia/common" + Slovenia: + $ref: + - "_terms_enum.yaml#/slovenia/common" + Solomon Islands: + $ref: + - "_terms_enum.yaml#/solomon_islands/common" + Somalia: + $ref: + - "_terms_enum.yaml#/somalia/common" + South Africa: + $ref: + - "_terms_enum.yaml#/south_africa/common" + South Korea: + $ref: + - "_terms_enum.yaml#/south_korea/common" + South Sudan: + $ref: + - "_terms_enum.yaml#/south_sudan/common" + Spain: + $ref: + - "_terms_enum.yaml#/spain/common" + Sri Lanka: + $ref: + - "_terms_enum.yaml#/sri_lanka/common" + State of Palestine: + $ref: + - "_terms_enum.yaml#/state_of_palestine/common" + Sudan: + $ref: + - "_terms_enum.yaml#/sudan/common" + Suriname: + $ref: + - "_terms_enum.yaml#/suriname/common" + Svalbard & Jan Mayen Islands: + $ref: + - "_terms_enum.yaml#/svalbard__jan_mayen_islands/common" + Sweden: + $ref: + - "_terms_enum.yaml#/sweden/common" + Switzerland: + $ref: + - "_terms_enum.yaml#/switzerland/common" + Syria: + $ref: + - "_terms_enum.yaml#/syria/common" + Taiwan: + $ref: + - "_terms_enum.yaml#/taiwan/common" + Tajikistan: + $ref: + - "_terms_enum.yaml#/tajikistan/common" + Tanzania: + $ref: + - "_terms_enum.yaml#/tanzania/common" + Thailand: + $ref: + - "_terms_enum.yaml#/thailand/common" + Timor-Leste: + $ref: + - "_terms_enum.yaml#/timorleste/common" + Togo: + $ref: + - "_terms_enum.yaml#/togo/common" + Tokelau: + $ref: + - "_terms_enum.yaml#/tokelau/common" + Tonga: + $ref: + - "_terms_enum.yaml#/tonga/common" + Trinidad and Tobago: + $ref: + - "_terms_enum.yaml#/trinidad_and_tobago/common" + Tunisia: + $ref: + - "_terms_enum.yaml#/tunisia/common" + Turkey: + $ref: + - "_terms_enum.yaml#/turkey/common" + Turkmenistan: + $ref: + - "_terms_enum.yaml#/turkmenistan/common" + Tuvalu: + $ref: + - "_terms_enum.yaml#/tuvalu/common" + Uganda: + $ref: + - "_terms_enum.yaml#/uganda/common" + Ukraine: + $ref: + - "_terms_enum.yaml#/ukraine/common" + United Arab Emirates: + $ref: + - "_terms_enum.yaml#/united_arab_emirates/common" + United Kingdom: + $ref: + - "_terms_enum.yaml#/united_kingdom/common" + United States: + $ref: + - "_terms_enum.yaml#/united_states/common" + Uruguay: + $ref: + - "_terms_enum.yaml#/uruguay/common" + Uzbekistan: + $ref: + - "_terms_enum.yaml#/uzbekistan/common" + Vanuatu: + $ref: + - "_terms_enum.yaml#/vanuatu/common" + Venezuela: + $ref: + - "_terms_enum.yaml#/venezuela/common" + Vietnam: + $ref: + - "_terms_enum.yaml#/vietnam/common" + Virgin Islands, British: + $ref: + - "_terms_enum.yaml#/virgin_islands_british/common" + Virgin Islands, U.S.: + $ref: + - "_terms_enum.yaml#/virgin_islands_us/common" + Wallis and Futuna: + $ref: + - "_terms_enum.yaml#/wallis_and_futuna/common" + Western Sahara: + $ref: + - "_terms_enum.yaml#/western_sahara/common" + Yemen: + $ref: + - "_terms_enum.yaml#/yemen/common" + Zambia: + $ref: + - "_terms_enum.yaml#/zambia/common" + Zimbabwe: + $ref: + - "_terms_enum.yaml#/zimbabwe/common" + + days_to_birth: + $ref: + - "_terms.yaml#/days_to_birth/common" + type: integer + maximum: 0 + minimum: -32872 + + days_to_death: + $ref: + - "_terms.yaml#/days_to_death/common" + type: integer + maximum: 32872 + minimum: -32872 + + education_level: + $ref: + - "_terms.yaml#/education_level/common" + enum: + - College Degree + - High School Graduate or GED + - Professional or Graduate Degree + - Some High School or Less + - Vocational College or Some College + - Unknown + - Not Reported + enumDef: + College Degree: + $ref: + - "_terms_enum.yaml#/college_degree/common" + Some High School or Less: + $ref: + - "_terms_enum.yaml#/some_highschool_or_less/common" + Vocational College or Some College: + $ref: + - "_terms_enum.yaml#/some_college_or_vocational_school/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + ethnicity: + $ref: + - "_terms.yaml#/ethnicity/common" + enum: + - hispanic or latino + - not hispanic or latino + - Unknown + - unknown + - not reported + - not allowed to collect + deprecated_enum: + - unknown + enumDef: + hispanic or latino: + $ref: + - "_terms_enum.yaml#/hispanic_or_latino/common" + not hispanic or latino: + $ref: + - "_terms_enum.yaml#/not_hispanic_or_latino/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + not allowed to collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + gender: + $ref: + - "_terms.yaml#/gender/common" + enum: + - female + - male + - unspecified + - unknown + - not reported + enumDef: + female: + $ref: + - "_terms_enum.yaml#/female/common" + male: + $ref: + - "_terms_enum.yaml#/male/common" + unspecified: + $ref: + - "_terms_enum.yaml#/unspecified/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + marital_status: + $ref: + - "_terms.yaml#/marital_status/common" + enum: + - Divorced + - Domestic Partnership + - Married + - Never Married + - Separated + - Widowed + - Unknown + - Not Reported + enumDef: + Divorced: + $ref: + - "_terms_enum.yaml#/divorced/common" + Domestic Partnership: + $ref: + - "_terms_enum.yaml#/domestic_partnership/common" + Married: + $ref: + - "_terms_enum.yaml#/married/common" + Never Married: + $ref: + - "_terms_enum.yaml#/never_married/common" + Separated: + $ref: + - "_terms_enum.yaml#/separated/common" + Widowed: + $ref: + - "_terms_enum.yaml#/widowed/common" + + occupation_duration_years: + $ref: + - "_terms.yaml#/occupation_duration_years/common" + type: integer + maximum: 89 + minimum: 0 + + population_group: + $ref: + - "_terms.yaml#/population_group/common" + enum: + - Ashkenazi Jew + + premature_at_birth: + $ref: + - "_terms.yaml#/premature_at_birth/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + race: + $ref: + - "_terms.yaml#/race/common" + enum: + - american indian or alaska native + - asian + - black or african american + - native hawaiian or other pacific islander + - white + - other + - Unknown + - unknown + - not reported + - not allowed to collect + deprecated_enum: + - unknown + enumDef: + american indian or alaska native: + $ref: + - "_terms_enum.yaml#/american_indian_or_alaska_native/common" + asian: + $ref: + - "_terms_enum.yaml#/asian/common" + black or african american: + $ref: + - "_terms_enum.yaml#/black_or_african_american/common" + native hawaiian or other pacific islander: + $ref: + - "_terms_enum.yaml#/native_hawaiian_or_other_pacific_islander/common" + white: + $ref: + - "_terms_enum.yaml#/white/demographic/race" + other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + not allowed to collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + vital_status: + $ref: + - "_terms.yaml#/vital_status/common" + enum: + - Alive + - Dead + - Unknown + - Not Reported + enumDef: + Alive: + $ref: + - "_terms_enum.yaml#/alive/common" + Dead: + $ref: + - "_terms_enum.yaml#/dead/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + weeks_gestation_at_birth: + $ref: + - "_terms.yaml#/weeks_gestation_at_birth/common" + type: number + minimum: 0 + + year_of_birth: + $ref: + - "_terms.yaml#/year_of_birth/common" + oneOf: + - type: integer + minimum: 1900 + - type: "null" + + year_of_death: + $ref: + - "_terms.yaml#/year_of_death/common" + type: integer + minimum: 1900 + + cases: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/diagnosis.yaml b/server/data_files/GDC/model-3.3.0/diagnosis.yaml new file mode 100644 index 0000000..79c2cfc --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/diagnosis.yaml @@ -0,0 +1,20218 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "diagnosis" +title: Diagnosis +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Data from the investigation, analysis and recognition of the presence and nature + of disease, condition, or injury from expressed signs and symptoms; also, the scientific + determination of any kind; the concise results of such an investigation. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: cases + backref: diagnoses + label: describes + target_type: case + multiplicity: many_to_one + required: true + +required: + - submitter_id + - age_at_diagnosis + - morphology + - primary_diagnosis + - diagnosis_is_primary_disease + - site_of_resection_or_biopsy + - tissue_or_organ_of_origin + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - metastasis_at_diagnosis_site + - micropapillary_features + - mitotic_count + - papillary_renal_cell_type + - pregnant_at_diagnosis + - primary_disease + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + adrenal_hormone: + $ref: + - "_terms.yaml#/adrenal_hormone/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + age_at_diagnosis: + $ref: + - "_terms.yaml#/age_at_diagnosis/common" + oneOf: + - type: integer + maximum: 32872 + minimum: 0 + - type: "null" + + ajcc_clinical_m: + $ref: + - "_terms.yaml#/ajcc_clinical_m/common" + enum: + - cM0 (i+) + - M0 + - M1 + - M1a + - M1b + - M1c + - MX + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + cM0 (i+): + $ref: + - "_terms_enum.yaml#/cm0_i/common" + M0: + $ref: + - "_terms_enum.yaml#/m0/common" + M1: + $ref: + - "_terms_enum.yaml#/m1/common" + M1a: + $ref: + - "_terms_enum.yaml#/m1a/common" + M1b: + $ref: + - "_terms_enum.yaml#/m1b/common" + M1c: + $ref: + - "_terms_enum.yaml#/m1c/common" + MX: + $ref: + - "_terms_enum.yaml#/mx/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ajcc_clinical_n: + $ref: + - "_terms.yaml#/ajcc_clinical_n/common" + enum: + - N0 + - N0 (i+) + - N0 (i-) + - N0 (mol+) + - N0 (mol-) + - N1 + - N1a + - N1b + - N1bI + - N1bII + - N1bIII + - N1bIV + - N1c + - N1mi + - N2 + - N2a + - N2b + - N2c + - N3 + - N3a + - N3b + - N3c + - N4 + - NX + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + N0: + $ref: + - "_terms_enum.yaml#/n0/common" + N0 (i+): + $ref: + - "_terms_enum.yaml#/n0_i/common" + N0 (i-): + $ref: + - "_terms_enum.yaml#/n0_i/common" + N0 (mol+): + $ref: + - "_terms_enum.yaml#/n0_mol/common" + N0 (mol-): + $ref: + - "_terms_enum.yaml#/n0_mol/common" + N1: + $ref: + - "_terms_enum.yaml#/n1/common" + N1a: + $ref: + - "_terms_enum.yaml#/n1a/common" + N1b: + $ref: + - "_terms_enum.yaml#/n1b/common" + N1bI: + $ref: + - "_terms_enum.yaml#/n1bi/common" + N1bII: + $ref: + - "_terms_enum.yaml#/n1bii/common" + N1bIII: + $ref: + - "_terms_enum.yaml#/n1biii/common" + N1bIV: + $ref: + - "_terms_enum.yaml#/n1biv/common" + N1c: + $ref: + - "_terms_enum.yaml#/n1c/common" + N1mi: + $ref: + - "_terms_enum.yaml#/n1mi/common" + N2: + $ref: + - "_terms_enum.yaml#/n2/common" + N2a: + $ref: + - "_terms_enum.yaml#/n2a/common" + N2b: + $ref: + - "_terms_enum.yaml#/n2b/common" + N2c: + $ref: + - "_terms_enum.yaml#/n2c/common" + N3: + $ref: + - "_terms_enum.yaml#/n3/common" + N3a: + $ref: + - "_terms_enum.yaml#/n3a/common" + N3b: + $ref: + - "_terms_enum.yaml#/n3b/common" + N3c: + $ref: + - "_terms_enum.yaml#/n3c/common" + N4: + $ref: + - "_terms_enum.yaml#/n4/common" + NX: + $ref: + - "_terms_enum.yaml#/nx/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ajcc_clinical_stage: + $ref: + - "_terms.yaml#/ajcc_clinical_stage/common" + enum: + - Stage 0 + - Stage 0a + - Stage 0is + - Stage I + - Stage IA + - Stage IA1 + - Stage IA2 + - Stage IA3 + - Stage IB + - Stage IB1 + - Stage IB2 + - Stage IB Cervix + - Stage IC + - Stage II + - Stage II Cervix + - Stage IIA + - Stage IIA1 + - Stage IIA2 + - Stage IIA Cervix + - Stage IIB + - Stage IIC + - Stage IIC1 + - Stage III + - Stage IIIA + - Stage IIIB + - Stage IIIC + - Stage IIIC1 + - Stage IIIC2 + - Stage IS + - Stage IV + - Stage IVA + - Stage IVB + - Stage IVC + - Stage Tis + - Stage X + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + - Stage IB Cervix + - Stage II Cervix + - Stage IIA Cervix + enumDef: + Stage 0: + $ref: + - "_terms_enum.yaml#/stage_0/diagnosis/ajcc_clinical_stage" + Stage 0a: + $ref: + - "_terms_enum.yaml#/stage_0a/common" + Stage 0is: + $ref: + - "_terms_enum.yaml#/stage_0is/common" + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/common" + Stage IA: + $ref: + - "_terms_enum.yaml#/stage_ia/common" + Stage IA1: + $ref: + - "_terms_enum.yaml#/stage_ia1/common" + Stage IA2: + $ref: + - "_terms_enum.yaml#/stage_ia2/common" + Stage IB: + $ref: + - "_terms_enum.yaml#/stage_ib/common" + Stage IB1: + $ref: + - "_terms_enum.yaml#/stage_ib1/common" + Stage IB2: + $ref: + - "_terms_enum.yaml#/stage_ib2/common" + Stage IB Cervix: + $ref: + - "_terms_enum.yaml#/stage_ib_cervix/common" + Stage IC: + $ref: + - "_terms_enum.yaml#/stage_ic/common" + Stage II: + $ref: + - "_terms_enum.yaml#/stage_ii/common" + Stage II Cervix: + $ref: + - "_terms_enum.yaml#/stage_ii_cervix/common" + Stage IIA: + $ref: + - "_terms_enum.yaml#/stage_iia/common" + Stage IIA1: + $ref: + - "_terms_enum.yaml#/stage_iia1/common" + Stage IIA2: + $ref: + - "_terms_enum.yaml#/stage_iia2/common" + Stage IIA Cervix: + $ref: + - "_terms_enum.yaml#/stage_iia_cervix/common" + Stage IIB: + $ref: + - "_terms_enum.yaml#/stage_iib/common" + Stage IIC: + $ref: + - "_terms_enum.yaml#/stage_iic/common" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/common" + Stage IIIA: + $ref: + - "_terms_enum.yaml#/stage_iiia/common" + Stage IIIB: + $ref: + - "_terms_enum.yaml#/stage_iiib/common" + Stage IIIC: + $ref: + - "_terms_enum.yaml#/stage_iiic/common" + Stage IIIC1: + $ref: + - "_terms_enum.yaml#/stage_iiic1/common" + Stage IIIC2: + $ref: + - "_terms_enum.yaml#/stage_iiic2/common" + Stage IS: + $ref: + - "_terms_enum.yaml#/stage_is/common" + Stage IV: + $ref: + - "_terms_enum.yaml#/stage_iv/common" + Stage IVA: + $ref: + - "_terms_enum.yaml#/stage_iva/common" + Stage IVB: + $ref: + - "_terms_enum.yaml#/stage_ivb/common" + Stage IVC: + $ref: + - "_terms_enum.yaml#/stage_ivc/common" + Stage Tis: + $ref: + - "_terms_enum.yaml#/stage_tis/common" + Stage X: + $ref: + - "_terms_enum.yaml#/stage_x/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ajcc_clinical_t: + $ref: + - "_terms.yaml#/ajcc_clinical_t/common" + enum: + - T0 + - T1 + - T1a + - T1a1 + - T1a2 + - T1b + - T1b1 + - T1b2 + - T1c + - T1mi + - T2 + - T2a + - T2a1 + - T2a2 + - T2b + - T2c + - T2d + - T3 + - T3a + - T3b + - T3c + - T3d + - T4 + - T4a + - T4b + - T4c + - T4d + - T4e + - Ta + - Tis + - Tis (DCIS) + - Tis (LCIS) + - Tis (Paget's) + - TX + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + T0: + $ref: + - "_terms_enum.yaml#/t0/common" + T1: + $ref: + - "_terms_enum.yaml#/t1/common" + T1a: + $ref: + - "_terms_enum.yaml#/t1a/common" + T1a1: + $ref: + - "_terms_enum.yaml#/t1a1/common" + T1a2: + $ref: + - "_terms_enum.yaml#/t1a2/common" + T1b: + $ref: + - "_terms_enum.yaml#/t1b/common" + T1b1: + $ref: + - "_terms_enum.yaml#/t1b1/diagnosis/ajcc_clinical_t" + T1b2: + $ref: + - "_terms_enum.yaml#/t1b2/diagnosis/ajcc_clinical_t" + T1c: + $ref: + - "_terms_enum.yaml#/t1c/common" + T1mi: + $ref: + - "_terms_enum.yaml#/t1mi/common" + T2: + $ref: + - "_terms_enum.yaml#/t2/common" + T2a: + $ref: + - "_terms_enum.yaml#/t2a/common" + T2a1: + $ref: + - "_terms_enum.yaml#/t2a1/diagnosis/ajcc_clinical_t" + T2a2: + $ref: + - "_terms_enum.yaml#/t2a2/diagnosis/ajcc_clinical_t" + T2b: + $ref: + - "_terms_enum.yaml#/t2b/common" + T2c: + $ref: + - "_terms_enum.yaml#/t2c/common" + T2d: + $ref: + - "_terms_enum.yaml#/t2d/common" + T3: + $ref: + - "_terms_enum.yaml#/t3/common" + T3a: + $ref: + - "_terms_enum.yaml#/t3a/common" + T3b: + $ref: + - "_terms_enum.yaml#/t3b/common" + T3c: + $ref: + - "_terms_enum.yaml#/t3c/common" + T3d: + $ref: + - "_terms_enum.yaml#/t3d/common" + T4: + $ref: + - "_terms_enum.yaml#/t4/common" + T4a: + $ref: + - "_terms_enum.yaml#/t4a/common" + T4b: + $ref: + - "_terms_enum.yaml#/t4b/common" + T4c: + $ref: + - "_terms_enum.yaml#/t4c/common" + T4d: + $ref: + - "_terms_enum.yaml#/t4d/common" + T4e: + $ref: + - "_terms_enum.yaml#/t4e/common" + Ta: + $ref: + - "_terms_enum.yaml#/ta/common" + Tis: + $ref: + - "_terms_enum.yaml#/tis/common" + Tis (DCIS): + $ref: + - "_terms_enum.yaml#/tis_dcis/common" + Tis (LCIS): + $ref: + - "_terms_enum.yaml#/tis_lcis/common" + Tis (Paget's): + $ref: + - "_terms_enum.yaml#/tis_pagets/common" + TX: + $ref: + - "_terms_enum.yaml#/tx/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ajcc_pathologic_m: + $ref: + - "_terms.yaml#/ajcc_pathologic_m/common" + enum: + - cM0 (i+) + - M0 + - M1 + - M1a + - M1b + - M1c + - M1d + - M2 + - MX + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + cM0 (i+): + $ref: + - "_terms_enum.yaml#/cm0_i/common" + M0: + $ref: + - "_terms_enum.yaml#/m0/common" + M1: + $ref: + - "_terms_enum.yaml#/m1/common" + M1a: + $ref: + - "_terms_enum.yaml#/m1a/common" + M1b: + $ref: + - "_terms_enum.yaml#/m1b/common" + M1c: + $ref: + - "_terms_enum.yaml#/m1c/common" + MX: + $ref: + - "_terms_enum.yaml#/mx/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ajcc_pathologic_n: + $ref: + - "_terms.yaml#/ajcc_pathologic_n/common" + enum: + - N0 + - N0 (i+) + - N0 (i-) + - N0 (mol+) + - N0 (mol-) + - N1 + - N1a + - N1b + - N1bI + - N1bII + - N1bIII + - N1bIV + - N1c + - N1mi + - N2 + - N2a + - N2b + - N2c + - N2mi + - N3 + - N3a + - N3b + - N3c + - N4 + - NX + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + N0: + $ref: + - "_terms_enum.yaml#/n0/common" + N0 (i+): + $ref: + - "_terms_enum.yaml#/n0_i/common" + N0 (i-): + $ref: + - "_terms_enum.yaml#/n0_i/common" + N0 (mol+): + $ref: + - "_terms_enum.yaml#/n0_mol/common" + N0 (mol-): + $ref: + - "_terms_enum.yaml#/n0_mol/common" + N1: + $ref: + - "_terms_enum.yaml#/n1/common" + N1a: + $ref: + - "_terms_enum.yaml#/n1a/common" + N1b: + $ref: + - "_terms_enum.yaml#/n1b/common" + N1bI: + $ref: + - "_terms_enum.yaml#/n1bi/common" + N1bII: + $ref: + - "_terms_enum.yaml#/n1bii/common" + N1bIII: + $ref: + - "_terms_enum.yaml#/n1biii/common" + N1bIV: + $ref: + - "_terms_enum.yaml#/n1biv/common" + N1c: + $ref: + - "_terms_enum.yaml#/n1c/common" + N1mi: + $ref: + - "_terms_enum.yaml#/n1mi/common" + N2: + $ref: + - "_terms_enum.yaml#/n2/common" + N2a: + $ref: + - "_terms_enum.yaml#/n2a/common" + N2b: + $ref: + - "_terms_enum.yaml#/n2b/common" + N2c: + $ref: + - "_terms_enum.yaml#/n2c/common" + N3: + $ref: + - "_terms_enum.yaml#/n3/common" + N3a: + $ref: + - "_terms_enum.yaml#/n3a/common" + N3b: + $ref: + - "_terms_enum.yaml#/n3b/common" + N3c: + $ref: + - "_terms_enum.yaml#/n3c/common" + N4: + $ref: + - "_terms_enum.yaml#/n4/common" + NX: + $ref: + - "_terms_enum.yaml#/nx/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ajcc_pathologic_stage: + $ref: + - "_terms.yaml#/ajcc_pathologic_stage/common" + enum: + - Stage 0 + - Stage 0a + - Stage 0is + - Stage I + - Stage IA + - Stage IA1 + - Stage IA2 + - Stage IA3 + - Stage IB + - Stage IB1 + - Stage IB2 + - Stage IC + - Stage II + - Stage IIA + - Stage IIA1 + - Stage IIA2 + - Stage IIB + - Stage IIC + - Stage III + - Stage IIIA + - Stage IIIA1 + - Stage IIIA2 + - Stage IIIB + - Stage IIIC + - Stage IIIC1 + - Stage IIIC2 + - Stage IIID + - Stage IS + - Stage IV + - Stage IVA + - Stage IVB + - Stage IVC + - Stage Tis + - Stage X + - Unknown + - Not Reported + enumDef: + Stage 0a: + $ref: + - "_terms_enum.yaml#/stage_0a/common" + Stage 0is: + $ref: + - "_terms_enum.yaml#/stage_0is/common" + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/common" + Stage IA: + $ref: + - "_terms_enum.yaml#/stage_ia/common" + Stage IA1: + $ref: + - "_terms_enum.yaml#/stage_ia1/common" + Stage IA2: + $ref: + - "_terms_enum.yaml#/stage_ia2/common" + Stage IB: + $ref: + - "_terms_enum.yaml#/stage_ib/common" + Stage IB1: + $ref: + - "_terms_enum.yaml#/stage_ib1/common" + Stage IB2: + $ref: + - "_terms_enum.yaml#/stage_ib2/common" + Stage IC: + $ref: + - "_terms_enum.yaml#/stage_ic/common" + Stage II: + $ref: + - "_terms_enum.yaml#/stage_ii/common" + Stage IIA: + $ref: + - "_terms_enum.yaml#/stage_iia/common" + Stage IIA1: + $ref: + - "_terms_enum.yaml#/stage_iia1/common" + Stage IIA2: + $ref: + - "_terms_enum.yaml#/stage_iia2/common" + Stage IIB: + $ref: + - "_terms_enum.yaml#/stage_iib/common" + Stage IIC: + $ref: + - "_terms_enum.yaml#/stage_iic/common" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/common" + Stage IIIA: + $ref: + - "_terms_enum.yaml#/stage_iiia/common" + Stage IIIB: + $ref: + - "_terms_enum.yaml#/stage_iiib/common" + Stage IIIC: + $ref: + - "_terms_enum.yaml#/stage_iiic/common" + Stage IIIC1: + $ref: + - "_terms_enum.yaml#/stage_iiic1/common" + Stage IIIC2: + $ref: + - "_terms_enum.yaml#/stage_iiic2/common" + Stage IIID: + $ref: + - "_terms_enum.yaml#/stage_iiid/common" + Stage IS: + $ref: + - "_terms_enum.yaml#/stage_is/common" + Stage IV: + $ref: + - "_terms_enum.yaml#/stage_iv/common" + Stage IVA: + $ref: + - "_terms_enum.yaml#/stage_iva/common" + Stage IVB: + $ref: + - "_terms_enum.yaml#/stage_ivb/common" + Stage IVC: + $ref: + - "_terms_enum.yaml#/stage_ivc/common" + Stage Tis: + $ref: + - "_terms_enum.yaml#/stage_tis/common" + Stage X: + $ref: + - "_terms_enum.yaml#/stage_x/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + ajcc_pathologic_t: + $ref: + - "_terms.yaml#/ajcc_pathologic_t/common" + enum: + - T0 + - T1 + - T1a + - T1a1 + - T1a2 + - T1b + - T1b1 + - T1b2 + - T1c + - T1c2 + - T1mi + - T2 + - T2a + - T2a1 + - T2a2 + - T2b + - T2c + - T2d + - T3 + - T3a + - T3b + - T3c + - T3d + - T4 + - T4a + - T4b + - T4c + - T4d + - T4e + - Ta + - Tis + - Tis (DCIS) + - Tis (LCIS) + - Tis (Paget's) + - TX + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + T0: + $ref: + - "_terms_enum.yaml#/t0/common" + T1: + $ref: + - "_terms_enum.yaml#/t1/common" + T1a: + $ref: + - "_terms_enum.yaml#/t1a/common" + T1a1: + $ref: + - "_terms_enum.yaml#/t1a1/common" + T1a2: + $ref: + - "_terms_enum.yaml#/t1a2/common" + T1b: + $ref: + - "_terms_enum.yaml#/t1b/common" + T1b1: + $ref: + - "_terms_enum.yaml#/t1b1/diagnosis/ajcc_pathologic_t" + T1b2: + $ref: + - "_terms_enum.yaml#/t1b2/diagnosis/ajcc_pathologic_t" + T1c: + $ref: + - "_terms_enum.yaml#/t1c/common" + T1mi: + $ref: + - "_terms_enum.yaml#/t1mi/common" + T2: + $ref: + - "_terms_enum.yaml#/t2/common" + T2a: + $ref: + - "_terms_enum.yaml#/t2a/common" + T2a1: + $ref: + - "_terms_enum.yaml#/t2a1/diagnosis/ajcc_pathologic_t" + T2a2: + $ref: + - "_terms_enum.yaml#/t2a2/diagnosis/ajcc_pathologic_t" + T2b: + $ref: + - "_terms_enum.yaml#/t2b/common" + T2c: + $ref: + - "_terms_enum.yaml#/t2c/common" + T2d: + $ref: + - "_terms_enum.yaml#/t2d/common" + T3: + $ref: + - "_terms_enum.yaml#/t3/common" + T3a: + $ref: + - "_terms_enum.yaml#/t3a/common" + T3b: + $ref: + - "_terms_enum.yaml#/t3b/common" + T3c: + $ref: + - "_terms_enum.yaml#/t3c/common" + T3d: + $ref: + - "_terms_enum.yaml#/t3d/common" + T4: + $ref: + - "_terms_enum.yaml#/t4/common" + T4a: + $ref: + - "_terms_enum.yaml#/t4a/common" + T4b: + $ref: + - "_terms_enum.yaml#/t4b/common" + T4c: + $ref: + - "_terms_enum.yaml#/t4c/common" + T4d: + $ref: + - "_terms_enum.yaml#/t4d/common" + T4e: + $ref: + - "_terms_enum.yaml#/t4e/common" + Ta: + $ref: + - "_terms_enum.yaml#/ta/common" + Tis: + $ref: + - "_terms_enum.yaml#/tis/common" + Tis (DCIS): + $ref: + - "_terms_enum.yaml#/tis_dcis/common" + Tis (LCIS): + $ref: + - "_terms_enum.yaml#/tis_lcis/common" + Tis (Paget's): + $ref: + - "_terms_enum.yaml#/tis_pagets/common" + TX: + $ref: + - "_terms_enum.yaml#/tx/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ajcc_serum_tumor_markers: + $ref: + - "_terms.yaml#/ajcc_serum_tumor_markers/common" + enum: + - S0 + - S1 + - S2 + - S3 + - SX + - Unknown + - Not Reported + + ajcc_staging_system_edition: + $ref: + - "_terms.yaml#/ajcc_staging_system_edition/common" + enum: + - 1st + - 2nd + - 3rd + - 4th + - 5th + - 6th + - 7th + - 8th + - Unknown + - Not Reported + enumDef: + 6th: + $ref: + - "_terms_enum.yaml#/6th/common" + 7th: + $ref: + - "_terms_enum.yaml#/7th/common" + 8th: + $ref: + - "_terms_enum.yaml#/8th/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + ann_arbor_b_symptoms: + $ref: + - "_terms.yaml#/ann_arbor_b_symptoms/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ann_arbor_b_symptoms_described: + $ref: + - "_terms.yaml#/ann_arbor_b_symptoms_described/common" + enum: + - Fever + - Night Sweats + - Weight Loss + - Other + - Unknown + - Not Reported + + ann_arbor_clinical_stage: + $ref: + - "_terms.yaml#/ann_arbor_clinical_stage/common" + enum: + - Stage I + - Stage II + - Stage III + - Stage IV + - Unknown + - Not Reported + enumDef: + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/diagnosis/ann_arbor_clinical_stage" + Stage II: + $ref: + - "_terms_enum.yaml#/stage_ii/diagnosis/ann_arbor_clinical_stage" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/diagnosis/ann_arbor_clinical_stage" + Stage IV: + $ref: + - "_terms_enum.yaml#/stage_iv/diagnosis/ann_arbor_clinical_stage" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + ann_arbor_extranodal_involvement: + $ref: + - "_terms.yaml#/ann_arbor_extranodal_involvement/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + ann_arbor_pathologic_stage: + $ref: + - "_terms.yaml#/ann_arbor_pathologic_stage/common" + enum: + - Stage I + - Stage II + - Stage III + - Stage IV + - Unknown + - Not Reported + enumDef: + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/diagnosis/ann_arbor_pathologic_stage" + Stage II: + $ref: + - "_terms_enum.yaml#/stage_ii/diagnosis/ann_arbor_pathologic_stage" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/diagnosis/ann_arbor_pathologic_stage" + Stage IV: + $ref: + - "_terms_enum.yaml#/stage_iv/diagnosis/ann_arbor_pathologic_stage" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + best_overall_response: + $ref: + - "_terms.yaml#/best_overall_response/common" + enum: + - AJ-Adjuvant Therapy + - CPD-Clinical Progression + - CR-Complete Response + - CRU-Complete Response Unconfirmed + - DU-Disease Unchanged + - IMR-Immunoresponse + - IPD-Immunoprogression + - MR-Minimal/Marginal Response + - MX-Mixed Response + - Non-CR/Non-PD-Non-CR/Non-PD + - NPB-No Palliative Benefit + - NR-No Response + - PA-Palliative Therapy + - PB-Palliative Benefit + - PD-Progressive Disease + - PPD-Pseudoprogression + - PR-Partial Response + - PSR-Pseudoresponse + - RD-Responsive Disease + - RP-Response + - RPD-Radiographic Progressive Disease + - sCR-Stringent Complete Response + - SD-Stable Disease + - SPD-Surgical Progression + - TE-Too Early + - VGPR-Very Good Partial Response + - Unknown + - Not Reported + enumDef: + AJ-Adjuvant Therapy: + $ref: + - "_terms_enum.yaml#/ajadjuvant_therapy/common" + CPD-Clinical Progression: + $ref: + - "_terms_enum.yaml#/cpdclinical_progression/common" + CR-Complete Response: + $ref: + - "_terms_enum.yaml#/crcomplete_response/common" + CRU-Complete Response Unconfirmed: + $ref: + - "_terms_enum.yaml#/crucomplete_response_unconfirmed/common" + DU-Disease Unchanged: + $ref: + - "_terms_enum.yaml#/dudisease_unchanged/common" + IMR-Immunoresponse: + $ref: + - "_terms_enum.yaml#/imrimmunoresponse/common" + IPD-Immunoprogression: + $ref: + - "_terms_enum.yaml#/ipdimmunoprogression/common" + MR-Minimal/Marginal Response: + $ref: + - "_terms_enum.yaml#/mrminimalmarginal_response/common" + MX-Mixed Response: + $ref: + - "_terms_enum.yaml#/mxmixed_response/common" + NPB-No Palliative Benefit: + $ref: + - "_terms_enum.yaml#/npbno_palliative_benefit/common" + NR-No Response: + $ref: + - "_terms_enum.yaml#/nrno_response/common" + PA-Palliative Therapy: + $ref: + - "_terms_enum.yaml#/papalliative_therapy/common" + PB-Palliative Benefit: + $ref: + - "_terms_enum.yaml#/pbpalliative_benefit/common" + PD-Progressive Disease: + $ref: + - "_terms_enum.yaml#/pdprogressive_disease/common" + PPD-Pseudoprogression: + $ref: + - "_terms_enum.yaml#/ppdpseudoprogression/common" + PR-Partial Response: + $ref: + - "_terms_enum.yaml#/prpartial_response/common" + PSR-Pseudoresponse: + $ref: + - "_terms_enum.yaml#/psrpseudoresponse/common" + RD-Responsive Disease: + $ref: + - "_terms_enum.yaml#/rdresponsive_disease/common" + RP-Response: + $ref: + - "_terms_enum.yaml#/rpresponse/common" + RPD-Radiographic Progressive Disease: + $ref: + - "_terms_enum.yaml#/rpdradiographic_progressive_disease/common" + sCR-Stringent Complete Response: + $ref: + - "_terms_enum.yaml#/scrstringent_complete_response/common" + SD-Stable Disease: + $ref: + - "_terms_enum.yaml#/sdstable_disease/common" + TE-Too Early: + $ref: + - "_terms_enum.yaml#/tetoo_early/common" + VGPR-Very Good Partial Response: + $ref: + - "_terms_enum.yaml#/vgprvery_good_partial_response/common" + + burkitt_lymphoma_clinical_variant: + $ref: + - "_terms.yaml#/burkitt_lymphoma_clinical_variant/common" + enum: + - Endemic + - Immunodeficiency-associated, adult + - Immunodeficiency-associated, pediatric + - Sporadic, adult + - Sporadic, pediatric + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + Endemic: + $ref: + - "_terms_enum.yaml#/endemic/common" + Immunodeficiency-associated, adult: + $ref: + - "_terms_enum.yaml#/immunodeficiencyassociated_adult/common" + Immunodeficiency-associated, pediatric: + $ref: + - "_terms_enum.yaml#/immunodeficiencyassociated_pediatric/common" + Sporadic, adult: + $ref: + - "_terms_enum.yaml#/sporadic_adult/common" + Sporadic, pediatric: + $ref: + - "_terms_enum.yaml#/sporadic_pediatric/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + calgb_risk_group: + $ref: + - "_terms.yaml#/calgb_risk_group/common" + enum: + - Favorable + - Intermediate/Normal + - N/A + - Poor + - Unknown + - Not Reported + + cancer_detection_method: + $ref: + - "_terms.yaml#/cancer_detection_method/common" + enum: + - Screening + - Surveillance + - Symptomatic + - Unknown + - Not Reported + + child_pugh_classification: + $ref: + - "_terms.yaml#/child_pugh_classification/common" + enum: + - A + - A5 + - A6 + - B + - B7 + - B8 + - B9 + - C + - C10 + - C11 + - C12 + - Unknown + - Not Reported + enumDef: + A: + $ref: + - "_terms_enum.yaml#/a/common" + A5: + $ref: + - "_terms_enum.yaml#/a5/common" + A6: + $ref: + - "_terms_enum.yaml#/a6/common" + B: + $ref: + - "_terms_enum.yaml#/b/common" + B7: + $ref: + - "_terms_enum.yaml#/b7/common" + B8: + $ref: + - "_terms_enum.yaml#/b8/common" + B9: + $ref: + - "_terms_enum.yaml#/b9/common" + C: + $ref: + - "_terms_enum.yaml#/c/common" + C10: + $ref: + - "_terms_enum.yaml#/c10/common" + C11: + $ref: + - "_terms_enum.yaml#/c11/common" + C12: + $ref: + - "_terms_enum.yaml#/c12/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + clark_level: + $ref: + - "_terms.yaml#/clark_level/common" + enum: + - I + - II + - III + - IV + - V + - Unknown + - Not Reported + enumDef: + I: + $ref: + - "_terms_enum.yaml#/i/diagnosis/clark_level" + II: + $ref: + - "_terms_enum.yaml#/ii/diagnosis/clark_level" + III: + $ref: + - "_terms_enum.yaml#/iii/diagnosis/clark_level" + IV: + $ref: + - "_terms_enum.yaml#/iv/diagnosis/clark_level" + V: + $ref: + - "_terms_enum.yaml#/v/diagnosis/clark_level" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + classification_of_tumor: + $ref: + - "_terms.yaml#/classification_of_tumor/common" + enum: + - metastasis + - Premalignant + - primary + - Prior primary + - Progression + - recurrence + - Subsequent Primary + - Synchronous primary + - other + - Unknown + - not reported + - Not Allowed To Collect + enumDef: + metastasis: + $ref: + - "_terms_enum.yaml#/metastasis/common" + Premalignant: + $ref: + - "_terms_enum.yaml#/premalignant/common" + primary: + $ref: + - "_terms_enum.yaml#/primary/common" + recurrence: + $ref: + - "_terms_enum.yaml#/recurrence/common" + other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + cog_liver_stage: + $ref: + - "_terms.yaml#/cog_liver_stage/common" + enum: + - Stage I + - Stage II + - Stage III + - Stage IV + - Unknown + - Not Reported + enumDef: + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/common" + Stage II: + $ref: + - "_terms_enum.yaml#/stage_ii/common" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/common" + Stage IV: + $ref: + - "_terms_enum.yaml#/stage_iv/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + cog_neuroblastoma_risk_group: + $ref: + - "_terms.yaml#/cog_neuroblastoma_risk_group/common" + enum: + - High Risk + - Intermediate Risk + - Low Risk + - Unknown + - Not Reported + enumDef: + High Risk: + $ref: + - "_terms_enum.yaml#/high_risk/common" + Intermediate Risk: + $ref: + - "_terms_enum.yaml#/intermediate_risk/common" + Low Risk: + $ref: + - "_terms_enum.yaml#/low_risk/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + cog_renal_stage: + $ref: + - "_terms.yaml#/cog_renal_stage/common" + enum: + - Stage I + - Stage II + - Stage III + - Stage IV + - Unknown + - Not Reported + enumDef: + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/diagnosis/cog_renal_stage" + Stage II: + $ref: + - "_terms_enum.yaml#/stage_ii/diagnosis/cog_renal_stage" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/diagnosis/cog_renal_stage" + Stage IV: + $ref: + - "_terms_enum.yaml#/stage_iv/diagnosis/cog_renal_stage" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + cog_rhabdomyosarcoma_risk_group: + $ref: + - "_terms.yaml#/cog_rhabdomyosarcoma_risk_group/common" + enum: + - High Risk + - Intermediate Risk + - Low Risk + - Unknown + - Not Reported + enumDef: + High Risk: + $ref: + - "_terms_enum.yaml#/high_risk/common" + Intermediate Risk: + $ref: + - "_terms_enum.yaml#/intermediate_risk/common" + Low Risk: + $ref: + - "_terms_enum.yaml#/low_risk/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + contiguous_organ_invaded: + description: >- + The organ or contiguous site the disease migrated to from the primary site. + enum: + - Adrenal + - Bladder + - Colon + - Inferior Vena Cava + - Kidney + - Liver + - Small Bowel + - Spleen + - Unknown + - Not Reported + enumDef: + Adrenal: + $ref: + - "_terms_enum.yaml#/adrenal_gland_nos/common" + Bladder: + $ref: + - "_terms_enum.yaml#/bladder_nos/common" + Colon: + $ref: + - "_terms_enum.yaml#/colon/common" + Inferior Vena Cava: + $ref: + - "_terms_enum.yaml#/inferior_vena_cava/common" + Kidney: + $ref: + - "_terms_enum.yaml#/kidney/common" + Liver: + $ref: + - "_terms_enum.yaml#/liver/common" + Small Bowel: + $ref: + - "_terms_enum.yaml#/small_bowel/common" + Spleen: + $ref: + - "_terms_enum.yaml#/spleen/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + days_to_best_overall_response: + $ref: + - "_terms.yaml#/days_to_best_overall_response/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_diagnosis: + $ref: + - "_terms.yaml#/days_to_diagnosis/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_last_follow_up: + $ref: + - "_terms.yaml#/days_to_last_follow_up/common" + oneOf: + - type: number + maximum: 32872 + minimum: -32872 + - type: "null" + + days_to_last_known_disease_status: + $ref: + - "_terms.yaml#/days_to_last_known_disease_status/common" + oneOf: + - type: number + maximum: 32872 + minimum: -32872 + - type: "null" + + days_to_recurrence: + $ref: + - "_terms.yaml#/days_to_recurrence/common" + oneOf: + - type: number + maximum: 32872 + minimum: -32872 + - type: "null" + + diagnosis_is_primary_disease: + $ref: + - "_terms.yaml#/diagnosis_is_primary_disease/common" + type: boolean + + double_expressor_lymphoma: + $ref: + - "_terms.yaml#/double_expressor_lymphoma/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + + double_hit_lymphoma: + $ref: + - "_terms.yaml#/double_hit_lymphoma/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + + eln_risk_classification: + $ref: + - "_terms.yaml#/eln_risk_classification/common" + enum: + - Adverse + - Favorable + - Intermediate + - Unknown + - Not Reported + enumDef: + Favorable: + $ref: + - "_terms_enum.yaml#/favorable/common" + Intermediate: + $ref: + - "_terms_enum.yaml#/intermediate/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + enneking_msts_grade: + $ref: + - "_terms.yaml#/enneking_msts_grade/common" + enum: + - High Grade (G2) + - Low Grade (G1) + - Unknown + - Not Reported + enumDef: + High Grade (G2): + $ref: + - "_terms_enum.yaml#/high_grade_g2/common" + Low Grade (G1): + $ref: + - "_terms_enum.yaml#/low_grade_g1/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + enneking_msts_metastasis: + $ref: + - "_terms.yaml#/enneking_msts_metastasis/common" + enum: + - No Metastasis (M0) + - Regional or Distant Metastasis (M1) + - Unknown + - Not Reported + enumDef: + No Metastasis (M0): + $ref: + - "_terms_enum.yaml#/no_metastasis_m0/common" + Regional or Distant Metastasis (M1): + $ref: + - "_terms_enum.yaml#/regional_or_distant_metastasis_m1/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + enneking_msts_stage: + $ref: + - "_terms.yaml#/enneking_msts_stage/common" + enum: + - Stage IA + - Stage IB + - Stage IIA + - Stage IIB + - Stage III + - Unknown + - Not Reported + enumDef: + Stage IA: + $ref: + - "_terms_enum.yaml#/stage_ia/diagnosis/enneking_msts_stage" + Stage IB: + $ref: + - "_terms_enum.yaml#/stage_ib/diagnosis/enneking_msts_stage" + Stage IIA: + $ref: + - "_terms_enum.yaml#/stage_iia/diagnosis/enneking_msts_stage" + Stage IIB: + $ref: + - "_terms_enum.yaml#/stage_iib/diagnosis/enneking_msts_stage" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/diagnosis/enneking_msts_stage" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + enneking_msts_tumor_site: + $ref: + - "_terms.yaml#/enneking_msts_tumor_site/common" + enum: + - Extracompartmental (T2) + - Intracompartmental (T1) + - Unknown + - Not Reported + enumDef: + Extracompartmental (T2): + $ref: + - "_terms_enum.yaml#/extracompartmental_t2/common" + Intracompartmental (T1): + $ref: + - "_terms_enum.yaml#/intracompartmental_t1/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + ensat_clinical_m: + $ref: + - "_terms.yaml#/ensat_clinical_m/common" + enum: + - M0 + - M1 + - Unknown + - Not Reported + enumDef: + M0: + $ref: + - "_terms_enum.yaml#/m0/diagnosis/ensat_clinical_m" + M1: + $ref: + - "_terms_enum.yaml#/m1/diagnosis/ensat_clinical_m" + + ensat_pathologic_n: + $ref: + - "_terms.yaml#/ensat_pathologic_n/common" + enum: + - N0 + - N1 + - Unknown + - Not Reported + enumDef: + N0: + $ref: + - "_terms_enum.yaml#/n0/diagnosis/ensat_pathologic_n" + N1: + $ref: + - "_terms_enum.yaml#/n1/diagnosis/ensat_pathologic_n" + + ensat_pathologic_stage: + $ref: + - "_terms.yaml#/ensat_pathologic_stage/common" + enum: + - Stage I + - Stage II + - Stage III + - Stage IV + - Unknown + - Not Reported + enumDef: + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/diagnosis/ensat_pathologic_stage" + Stage II: + $ref: + - "_terms_enum.yaml#/stage_ii/diagnosis/ensat_pathologic_stage" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/diagnosis/ensat_pathologic_stage" + Stage IV: + $ref: + - "_terms_enum.yaml#/stage_iv/diagnosis/ensat_pathologic_stage" + + ensat_pathologic_t: + $ref: + - "_terms.yaml#/ensat_pathologic_t/common" + enum: + - T1 + - T2 + - T3 + - T4 + - Unknown + - Not Reported + enumDef: + T1: + $ref: + - "_terms_enum.yaml#/t1/diagnosis/ensat_pathologic_t" + T2: + $ref: + - "_terms_enum.yaml#/t2/diagnosis/ensat_pathologic_t" + T3: + $ref: + - "_terms_enum.yaml#/t3/diagnosis/ensat_pathologic_t" + T4: + $ref: + - "_terms_enum.yaml#/t4/diagnosis/ensat_pathologic_t" + + esophageal_columnar_dysplasia_degree: + $ref: + - "_terms.yaml#/esophageal_columnar_dysplasia_degree/common" + enum: + - High Grade Dysplasia + - Indefinite for Dysplasia + - Low Grade Dysplasia + - Negative/ No Dysplasia + - Unknown + - Not Reported + enumDef: + High Grade Dysplasia: + $ref: + - "_terms_enum.yaml#/high_grade_dysplasia/common" + Indefinite for Dysplasia: + $ref: + - "_terms_enum.yaml#/indefinite_for_dysplasia/common" + Low Grade Dysplasia: + $ref: + - "_terms_enum.yaml#/low_grade_dysplasia/common" + Negative/ No Dysplasia: + $ref: + - "_terms_enum.yaml#/negative_no_dysplasia/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + esophageal_columnar_metaplasia_present: + $ref: + - "_terms.yaml#/esophageal_columnar_metaplasia_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + fab_morphology_code: + $ref: + - "_terms.yaml#/fab_morphology_code/common" + enum: + - M0 + - M1 + - M2 + - M3 + - M4 + - M5 + - M6 + - M7 + - Not Classified + + figo_stage: + $ref: + - "_terms.yaml#/figo_stage/common" + enum: + - Stage 0 + - Stage I + - Stage IA + - Stage IA1 + - Stage IA2 + - Stage IB + - Stage IB1 + - Stage IB2 + - Stage IC + - Stage IC1 + - Stage IC2 + - Stage IC3 + - Stage II + - Stage IIA + - Stage IIA1 + - Stage IIA2 + - Stage IIB + - Stage IIC + - Stage III + - Stage IIIA + - Stage IIIA1 + - Stage IIIA2 + - Stage IIIAi + - Stage IIIAii + - Stage IIIB + - Stage IIIC + - Stage IIIC1 + - Stage IIIC2 + - Stage IV + - Stage IVA + - Stage IVB + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + Stage 0: + $ref: + - "_terms_enum.yaml#/stage_0/diagnosis/figo_stage" + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/diagnosis/figo_stage" + Stage IA: + $ref: + - "_terms_enum.yaml#/stage_ia/diagnosis/figo_stage" + Stage IA1: + $ref: + - "_terms_enum.yaml#/stage_ia1/diagnosis/figo_stage" + Stage IA2: + $ref: + - "_terms_enum.yaml#/stage_ia2/diagnosis/figo_stage" + Stage IB: + $ref: + - "_terms_enum.yaml#/stage_ib/diagnosis/figo_stage" + Stage IB1: + $ref: + - "_terms_enum.yaml#/stage_ib1/diagnosis/figo_stage" + Stage IB2: + $ref: + - "_terms_enum.yaml#/stage_ib2/diagnosis/figo_stage" + Stage IC: + $ref: + - "_terms_enum.yaml#/stage_ic/diagnosis/figo_stage" + Stage IC1: + $ref: + - "_terms_enum.yaml#/stage_ic1/common" + Stage IC2: + $ref: + - "_terms_enum.yaml#/stage_ic2/common" + Stage IC3: + $ref: + - "_terms_enum.yaml#/stage_ic3/common" + Stage II: + $ref: + - "_terms_enum.yaml#/stage_ii/diagnosis/figo_stage" + Stage IIA: + $ref: + - "_terms_enum.yaml#/stage_iia/diagnosis/figo_stage" + Stage IIA1: + $ref: + - "_terms_enum.yaml#/stage_iia1/diagnosis/figo_stage" + Stage IIA2: + $ref: + - "_terms_enum.yaml#/stage_iia2/diagnosis/figo_stage" + Stage IIB: + $ref: + - "_terms_enum.yaml#/stage_iib/diagnosis/figo_stage" + Stage IIC: + $ref: + - "_terms_enum.yaml#/stage_iic/common" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/diagnosis/figo_stage" + Stage IIIA: + $ref: + - "_terms_enum.yaml#/stage_iiia/diagnosis/figo_stage" + Stage IIIA1: + $ref: + - "_terms_enum.yaml#/stage_iiia1/common" + Stage IIIA2: + $ref: + - "_terms_enum.yaml#/stage_iiia2/common" + Stage IIIAi: + $ref: + - "_terms_enum.yaml#/stage_iiiai/common" + Stage IIIAii: + $ref: + - "_terms_enum.yaml#/stage_iiiaii/common" + Stage IIIB: + $ref: + - "_terms_enum.yaml#/stage_iiib/diagnosis/figo_stage" + Stage IIIC: + $ref: + - "_terms_enum.yaml#/stage_iiic/diagnosis/figo_stage" + Stage IIIC1: + $ref: + - "_terms_enum.yaml#/stage_iiic1/diagnosis/figo_stage" + Stage IIIC2: + $ref: + - "_terms_enum.yaml#/stage_iiic2/diagnosis/figo_stage" + Stage IV: + $ref: + - "_terms_enum.yaml#/stage_iv/diagnosis/figo_stage" + Stage IVA: + $ref: + - "_terms_enum.yaml#/stage_iva/diagnosis/figo_stage" + Stage IVB: + $ref: + - "_terms_enum.yaml#/stage_ivb/diagnosis/figo_stage" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + figo_staging_edition_year: + $ref: + - "_terms.yaml#/figo_staging_edition_year/common" + enum: + - "1988" + - "1995" + - "2009" + + first_symptom_longest_duration: + description: >- + The length of time the first presenting symptom occurred that related to the + diagnosis of the patient with cancer. + enum: + - 0-30 Days + - 31-90 Days + - 91-180 Days + - '>=181 Days' + + first_symptom_prior_to_diagnosis: + $ref: + - "_terms.yaml#/first_symptom_prior_to_diagnosis/common" + enum: + - Altered Mental Status + - Headaches + - Motor or Movement Changes + - Seizures + - Sensory Changes + - Visual Changes + - Unknown + - Not Reported + enumDef: + Altered Mental Status: + $ref: + - "_terms_enum.yaml#/altered_mental_status/common" + Headaches: + $ref: + - "_terms_enum.yaml#/headaches/common" + Motor or Movement Changes: + $ref: + - "_terms_enum.yaml#/motor_or_movement_changes/common" + Seizures: + $ref: + - "_terms_enum.yaml#/seizures/common" + Sensory Changes: + $ref: + - "_terms_enum.yaml#/sensory_changes/common" + Visual Changes: + $ref: + - "_terms_enum.yaml#/visual_changes/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + gastric_esophageal_junction_involvement: + $ref: + - "_terms.yaml#/gastric_esophageal_junction_involvement/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + gleason_grade_group: + $ref: + - "_terms.yaml#/gleason_grade_group/common" + enum: + - Group 1 + - Group 2 + - Group 3 + - Group 4 + - Group 5 + - Unknown + - Not Reported + enumDef: + Group 1: + $ref: + - "_terms_enum.yaml#/group_1/common" + Group 2: + $ref: + - "_terms_enum.yaml#/group_2/common" + Group 3: + $ref: + - "_terms_enum.yaml#/group_3/common" + Group 4: + $ref: + - "_terms_enum.yaml#/group_4/common" + Group 5: + $ref: + - "_terms_enum.yaml#/group_5/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + gleason_grade_tertiary: + $ref: + - "_terms.yaml#/gleason_grade_tertiary/common" + enum: + - Pattern 4 + - Pattern 5 + - Unknown + - Not Reported + enumDef: + Pattern 4: + $ref: + - "_terms_enum.yaml#/pattern_4/common" + Pattern 5: + $ref: + - "_terms_enum.yaml#/pattern_5/common" + + gleason_patterns_percent: + $ref: + - "_terms.yaml#/gleason_patterns_percent/common" + type: integer + maximum: 100 + minimum: 0 + + gleason_score: + $ref: + - "_terms.yaml#/gleason_score/common" + type: integer + maximum: 10 + minimum: 0 + + goblet_cells_columnar_mucosa_present: + $ref: + - "_terms.yaml#/goblet_cells_columnar_mucosa_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + icd_10_code: + $ref: + - "_terms.yaml#/icd_10_code/common" + type: string + pattern: "^[A-TV-Z][0-9][A-Z0-9](\\.?[A-Z0-9]{1,4})?$" + + igcccg_stage: + $ref: + - "_terms.yaml#/igcccg_stage/common" + enum: + - Good Prognosis + - Intermediate Prognosis + - Poor Prognosis + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + inpc_grade: + $ref: + - "_terms.yaml#/inpc_grade/common" + enum: + - Differentiating + - Poorly Differentiated + - Undifferentiated + - Undifferentiated or Poorly Differentiated + - Unknown + - Not Reported + enumDef: + Differentiating: + $ref: + - "_terms_enum.yaml#/differentiating/common" + Poorly Differentiated: + $ref: + - "_terms_enum.yaml#/poorly_differentiated_neuroblastoma/common" + Undifferentiated: + $ref: + - "_terms_enum.yaml#/undifferentiated/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + inpc_histologic_group: + $ref: + - "_terms.yaml#/inpc_histologic_group/common" + enum: + - Favorable + - Unfavorable + - Unknown + - Not Reported + enumDef: + Favorable: + $ref: + - "_terms_enum.yaml#/favorable/common" + Unfavorable: + $ref: + - "_terms_enum.yaml#/unfavorable/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + inrg_stage: + $ref: + - "_terms.yaml#/inrg_stage/common" + enum: + - L1 + - L2 + - M + - Ms + - Unknown + - Not Reported + enumDef: + L1: + $ref: + - "_terms_enum.yaml#/l1/common" + L2: + $ref: + - "_terms_enum.yaml#/l2/common" + M: + $ref: + - "_terms_enum.yaml#/m/common" + Ms: + $ref: + - "_terms_enum.yaml#/ms/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + inss_stage: + $ref: + - "_terms.yaml#/inss_stage/common" + enum: + - Stage 1 + - Stage 2A + - Stage 2B + - Stage 3 + - Stage 4 + - Stage 4S + - Unknown + - Not Reported + enumDef: + Stage 1: + $ref: + - "_terms_enum.yaml#/stage_1/common" + Stage 2A: + $ref: + - "_terms_enum.yaml#/stage_2a/common" + Stage 2B: + $ref: + - "_terms_enum.yaml#/stage_2b/common" + Stage 3: + $ref: + - "_terms_enum.yaml#/stage_3/common" + Stage 4: + $ref: + - "_terms_enum.yaml#/stage_4/common" + Stage 4S: + $ref: + - "_terms_enum.yaml#/stage_4s/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + international_prognostic_index: + $ref: + - "_terms.yaml#/international_prognostic_index/common" + enum: + - High Risk + - High-Intermediate Risk + - Low Risk + - Low-Intermediate Risk + - Unknown + - Not Reported + enumDef: + High Risk: + $ref: + - "_terms_enum.yaml#/high_risk/diagnosis/international_prognostic_index" + High-Intermediate Risk: + $ref: + - "_terms_enum.yaml#/highintermediate_risk/common" + Low Risk: + $ref: + - "_terms_enum.yaml#/low_risk/diagnosis/international_prognostic_index" + Low-Intermediate Risk: + $ref: + - "_terms_enum.yaml#/lowintermediate_risk/common" + + irs_group: + $ref: + - "_terms.yaml#/irs_group/common" + enum: + - Group I + - Group Ia + - Group Ib + - Group II + - Group IIa + - Group IIb + - Group IIc + - Group III + - Group IIIa + - Group IIIb + - Group IV + - Unknown + - Not Reported + enumDef: + Group I: + $ref: + - "_terms_enum.yaml#/group_i/common" + Group Ia: + $ref: + - "_terms_enum.yaml#/group_ia/common" + Group Ib: + $ref: + - "_terms_enum.yaml#/group_ib/common" + Group II: + $ref: + - "_terms_enum.yaml#/group_ii/common" + Group IIa: + $ref: + - "_terms_enum.yaml#/group_iia/common" + Group IIb: + $ref: + - "_terms_enum.yaml#/group_iib/common" + Group IIc: + $ref: + - "_terms_enum.yaml#/group_iic/common" + Group III: + $ref: + - "_terms_enum.yaml#/group_iii/common" + Group IIIa: + $ref: + - "_terms_enum.yaml#/group_iiia/common" + Group IIIb: + $ref: + - "_terms_enum.yaml#/group_iiib/common" + Group IV: + $ref: + - "_terms_enum.yaml#/group_iv/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + irs_stage: + $ref: + - "_terms.yaml#/irs_stage/common" + enum: + - "1" + - "2" + - "3" + - "4" + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + ishak_fibrosis_score: + $ref: + - "_terms.yaml#/ishak_fibrosis_score/common" + enum: + - 0 - No Fibrosis + - 1,2 - Portal Fibrosis + - 3,4 - Fibrous Septa + - 5 - Nodular Formation and Incomplete Cirrhosis + - 6 - Established Cirrhosis + - Unknown + - Not Reported + enumDef: + 0 - No Fibrosis: + $ref: + - "_terms_enum.yaml#/0__no_fibrosis/common" + 1,2 - Portal Fibrosis: + $ref: + - "_terms_enum.yaml#/12__portal_fibrosis/common" + 3,4 - Fibrous Septa: + $ref: + - "_terms_enum.yaml#/34__fibrous_septa/common" + 5 - Nodular Formation and Incomplete Cirrhosis: + $ref: + - "_terms_enum.yaml#/5__nodular_formation_and_incomplete_cirrhosis/common" + 6 - Established Cirrhosis: + $ref: + - "_terms_enum.yaml#/6__established_cirrhosis/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + iss_stage: + $ref: + - "_terms.yaml#/iss_stage/common" + enum: + - I + - II + - III + - Unknown + - Not Reported + enumDef: + I: + $ref: + - "_terms_enum.yaml#/i/common" + II: + $ref: + - "_terms_enum.yaml#/ii/common" + III: + $ref: + - "_terms_enum.yaml#/iii/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + last_known_disease_status: + $ref: + - "_terms.yaml#/last_known_disease_status/common" + enum: + - Biochemical evidence of disease without structural correlate + - Distant met recurrence/progression + - Loco-regional recurrence/progression + - Tumor free + - Unknown tumor status + - With tumor + - not reported + - Not Allowed To Collect + enumDef: + Biochemical evidence of disease without structural correlate: + $ref: + - "_terms_enum.yaml#/biochemical_evidence_of_disease_without_structural_correlate/common" + Tumor free: + $ref: + - "_terms_enum.yaml#/tumor_free/common" + Unknown tumor status: + $ref: + - "_terms_enum.yaml#/unknown_tumor_status/common" + With tumor: + $ref: + - "_terms_enum.yaml#/with_tumor/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + laterality: + $ref: + - "_terms.yaml#/laterality/common" + enum: + - Bilateral + - Left + - Midline + - Right + - Unilateral + - Unknown + - Not Reported + enumDef: + Bilateral: + $ref: + - "_terms_enum.yaml#/bilateral/common" + Left: + $ref: + - "_terms_enum.yaml#/left/common" + Midline: + $ref: + - "_terms_enum.yaml#/midline/common" + Right: + $ref: + - "_terms_enum.yaml#/right/common" + Unilateral: + $ref: + - "_terms_enum.yaml#/unilateral/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + margin_distance: + $ref: + - "_terms.yaml#/margin_distance/common" + type: number + minimum: 0 + + margins_involved_site: + $ref: + - "_terms.yaml#/margins_involved_site/common" + enum: + - Gerota Fascia + - Parenchyma + - Perinephric Fat + - Renal + - Renal Capsule + - Renal Sinus + - Renal Vein + - Ureter + - Unknown + - Not Reported + enumDef: + Ureter: + $ref: + - "_terms_enum.yaml#/ureter/common" + + masaoka_stage: + $ref: + - "_terms.yaml#/masaoka_stage/common" + enum: + - Stage I + - Stage IIa + - Stage IIb + - Stage III + - Stage IVa + - Stage IVb + - Unknown + - Not Reported + enumDef: + Stage I: + $ref: + - "_terms_enum.yaml#/stage_i/diagnosis/masaoka_stage" + Stage IIa: + $ref: + - "_terms_enum.yaml#/stage_iia/diagnosis/masaoka_stage" + Stage IIb: + $ref: + - "_terms_enum.yaml#/stage_iib/diagnosis/masaoka_stage" + Stage III: + $ref: + - "_terms_enum.yaml#/stage_iii/diagnosis/masaoka_stage" + Stage IVa: + $ref: + - "_terms_enum.yaml#/stage_iva/diagnosis/masaoka_stage" + Stage IVb: + $ref: + - "_terms_enum.yaml#/stage_ivb/diagnosis/masaoka_stage" + + max_tumor_bulk_site: + $ref: + - "_terms.yaml#/max_tumor_bulk_site/common" + enum: + - Adrenal + - Appendix + - Ascites/peritoneum + - Axillary lymph nodes + - Bone marrow + - Brain + - Breast + - Cervical lymph nodes + - Colon + - Iliac + - Iliac-external + - Inguinal + - Kidney + - Liver + - Lung + - Mandible + - Maxilla + - Mediastinal lymph nodes + - Mediastinal soft tissue + - Mesenteric lymph nodes + - Neck + - No known nodal involvement + - Oropharynx + - Ovary + - Pancreas + - Paraaortic lymph nodes + - Parotid gland + - Peri-orbital soft tissue + - Pericardium + - Retroperitoneal lymph nodes + - Small intestine + - Soft tissue (muscle, ligaments, subcutaneous) + - Splenic lymph nodes + - Stomach + - Submandibular lymph nodes + - Supraclavicular lymph nodes + - Thyroid + - Other + + medulloblastoma_molecular_classification: + $ref: + - "_terms.yaml#/medulloblastoma_molecular_classification/common" + enum: + - Non-WNT/non-SHH Activated + - Not Determined + - SHH-Activated + - WNT-Activated + - Unknown + - Not Reported + enumDef: + Non-WNT/non-SHH Activated: + $ref: + - "_terms_enum.yaml#/nonwntnonshh_activated/common" + Not Determined: + $ref: + - "_terms_enum.yaml#/not_determined/common" + SHH-Activated: + $ref: + - "_terms_enum.yaml#/shhactivated/common" + WNT-Activated: + $ref: + - "_terms_enum.yaml#/wntactivated/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + melanoma_known_primary: + description: >- + A melanoma which has metastasized from a known primary anatomic site. + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + metastasis_at_diagnosis: + $ref: + - "_terms.yaml#/metastasis_at_diagnosis/common" + enum: + - Distant Metastasis + - Metastasis, NOS + - No Metastasis + - Regional Metastasis + - Unknown + - Not Reported + enumDef: + Distant Metastasis: + $ref: + - "_terms_enum.yaml#/distant_metastasis/common" + Metastasis, NOS: + $ref: + - "_terms_enum.yaml#/metastasis_nos/common" + No Metastasis: + $ref: + - "_terms_enum.yaml#/no_metastasis/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + metastasis_at_diagnosis_site: + $ref: + - "_terms.yaml#/metastasis_at_diagnosis_site/common" + enum: + - Abdomen + - Adrenal Gland + - Ascites + - Bladder + - Bone + - Bone Marrow + - Brain + - Bronchus + - Central Nervous System + - Cerebrospinal Fluid + - Colon + - Distant Nodes + - Distant Organ + - Esophagus + - Gastrointestinal Tract + - Groin + - Head, Face or Neck, NOS + - Heart + - Kidney + - Liver + - Lung + - Lymph Node, Axillary + - Lymph Node, Inguinal + - Lymph Node, NOS + - Lymph Node, Regional + - Lymph Node, Subcarinal + - Mediastinum + - Neck + - Omentum + - Ovary + - Pancreas + - Pelvis + - Peritoneal Cavity + - Peritoneum + - Pleura + - Retroperitoneum + - Scalp + - Skin + - Small Intestine + - Soft Tissue + - Spinal Cord + - Spleen + - Stomach + - Urethra + - Uterine Adnexa + - Vertebral Canal + - Vulva, NOS + - Unknown + - Not Reported + enumDef: + Abdomen: + $ref: + - "_terms_enum.yaml#/abdomen/common" + Adrenal Gland: + $ref: + - "_terms_enum.yaml#/adrenal_gland/common" + Ascites: + $ref: + - "_terms_enum.yaml#/ascites/common" + Bone: + $ref: + - "_terms_enum.yaml#/bone/common" + Bone Marrow: + $ref: + - "_terms_enum.yaml#/bone_marrow/common" + Brain: + $ref: + - "_terms_enum.yaml#/brain/common" + Central Nervous System: + $ref: + - "_terms_enum.yaml#/central_nervous_system/common" + Cerebrospinal Fluid: + $ref: + - "_terms_enum.yaml#/cerebrospinal_fluid/common" + Colon: + $ref: + - "_terms_enum.yaml#/colon/common" + Groin: + $ref: + - "_terms_enum.yaml#/groin/common" + Kidney: + $ref: + - "_terms_enum.yaml#/kidney/common" + Liver: + $ref: + - "_terms_enum.yaml#/liver/common" + Lung: + $ref: + - "_terms_enum.yaml#/lung/common" + Lymph Node, Axillary: + $ref: + - "_terms_enum.yaml#/lymph_node_axillary/common" + Lymph Node, Inguinal: + $ref: + - "_terms_enum.yaml#/lymph_node_inguinal/common" + Lymph Node, NOS: + $ref: + - "_terms_enum.yaml#/lymph_node_nos/common" + Mediastinum: + $ref: + - "_terms_enum.yaml#/mediastinum/common" + Neck: + $ref: + - "_terms_enum.yaml#/neck/common" + Omentum: + $ref: + - "_terms_enum.yaml#/omentum/common" + Ovary: + $ref: + - "_terms_enum.yaml#/ovary/common" + Pancreas: + $ref: + - "_terms_enum.yaml#/pancreas/common" + Pelvis: + $ref: + - "_terms_enum.yaml#/pelvis/common" + Peritoneal Cavity: + $ref: + - "_terms_enum.yaml#/peritoneal_cavity/common" + Peritoneum: + $ref: + - "_terms_enum.yaml#/peritoneum/common" + Pleura: + $ref: + - "_terms_enum.yaml#/pleura/common" + Scalp: + $ref: + - "_terms_enum.yaml#/scalp/common" + Skin: + $ref: + - "_terms_enum.yaml#/skin/common" + Small Intestine: + $ref: + - "_terms_enum.yaml#/small_intestine/common" + Soft Tissue: + $ref: + - "_terms_enum.yaml#/soft_tissue/common" + Spinal Cord: + $ref: + - "_terms_enum.yaml#/spinal_cord/common" + Uterine Adnexa: + $ref: + - "_terms_enum.yaml#/uterine_adnexa/common" + Vertebral Canal: + $ref: + - "_terms_enum.yaml#/vertebral_canal/common" + Vulva, NOS: + $ref: + - "_terms_enum.yaml#/vulva_nos/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + method_of_diagnosis: + $ref: + - "_terms.yaml#/method_of_diagnosis/common" + enum: + - Autopsy + - Biopsy + - Blood Draw + - Bone Marrow Aspirate + - Core Biopsy + - Cystoscopy + - Cytology + - Debulking + - Diagnostic Imaging + - Dilation and Curettage Procedure + - Enucleation + - Excisional Biopsy + - Exoresection + - Fine Needle Aspiration + - Imaging + - Incisional Biopsy + - Laparoscopy + - Laparotomy + - Orchiectomy + - Pap Smear + - Pathologic Review + - Physical Exam + - Surgical Resection + - Thoracentesis + - Ultrasound Guided Biopsy + - Other + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + Autopsy: + $ref: + - "_terms_enum.yaml#/autopsy/common" + Biopsy: + $ref: + - "_terms_enum.yaml#/biopsy/common" + Blood Draw: + $ref: + - "_terms_enum.yaml#/blood_draw/common" + Bone Marrow Aspirate: + $ref: + - "_terms_enum.yaml#/bone_marrow_aspirate/common" + Core Biopsy: + $ref: + - "_terms_enum.yaml#/core_biopsy/common" + Cystoscopy: + $ref: + - "_terms_enum.yaml#/cystoscopy/common" + Cytology: + $ref: + - "_terms_enum.yaml#/cytology/common" + Debulking: + $ref: + - "_terms_enum.yaml#/debulking/common" + Diagnostic Imaging: + $ref: + - "_terms_enum.yaml#/diagnostic_imaging/common" + Dilation and Curettage Procedure: + $ref: + - "_terms_enum.yaml#/dilation_and_curettage_procedure/common" + Enucleation: + $ref: + - "_terms_enum.yaml#/enucleation/common" + Excisional Biopsy: + $ref: + - "_terms_enum.yaml#/excisional_biopsy/common" + Fine Needle Aspiration: + $ref: + - "_terms_enum.yaml#/fine_needle_aspiration/common" + Imaging: + $ref: + - "_terms_enum.yaml#/imaging/common" + Incisional Biopsy: + $ref: + - "_terms_enum.yaml#/incisional_biopsy/common" + Laparoscopy: + $ref: + - "_terms_enum.yaml#/laparoscopy/common" + Laparotomy: + $ref: + - "_terms_enum.yaml#/laparotomy/common" + Pap Smear: + $ref: + - "_terms_enum.yaml#/pap_smear/common" + Pathologic Review: + $ref: + - "_terms_enum.yaml#/pathologic_review/common" + Physical Exam: + $ref: + - "_terms_enum.yaml#/physical_exam/common" + Surgical Resection: + $ref: + - "_terms_enum.yaml#/surgical_resection/common" + Thoracentesis: + $ref: + - "_terms_enum.yaml#/thoracentesis/common" + Ultrasound Guided Biopsy: + $ref: + - "_terms_enum.yaml#/ultrasound_guided_biopsy/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + micropapillary_features: + $ref: + - "_terms.yaml#/micropapillary_features/common" + enum: + - Absent + - Present + - Unknown + - Not Reported + enumDef: + Absent: + $ref: + - "_terms_enum.yaml#/absent/common" + Present: + $ref: + - "_terms_enum.yaml#/present/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + mitosis_karyorrhexis_index: + $ref: + - "_terms.yaml#/mitosis_karyorrhexis_index/common" + enum: + - High + - Intermediate + - Low + - Unknown + - Not Reported + enumDef: + High: + $ref: + - "_terms_enum.yaml#/high/common" + Intermediate: + $ref: + - "_terms_enum.yaml#/intermediate/common" + Low: + $ref: + - "_terms_enum.yaml#/low/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + mitotic_count: + $ref: + - "_terms.yaml#/mitotic_count/common" + type: integer + minimum: 0 + + morphology: + $ref: + - "_terms.yaml#/morphology/common" + enum: + - 8000/0 + - 8000/1 + - 8000/3 + - 8000/6 + - 8000/9 + - 8001/0 + - 8001/1 + - 8001/3 + - 8002/3 + - 8003/3 + - 8004/3 + - 8005/0 + - 8005/3 + - 8010/0 + - 8010/2 + - 8010/3 + - 8010/6 + - 8010/9 + - 8011/0 + - 8011/3 + - 8012/3 + - 8013/3 + - 8014/3 + - 8015/3 + - 8020/3 + - 8020/6 + - 8021/3 + - 8022/3 + - 8023/3 + - 8030/3 + - 8031/3 + - 8032/3 + - 8033/3 + - 8034/3 + - 8035/3 + - 8040/0 + - 8040/1 + - 8040/3 + - 8041/3 + - 8041/6 + - 8041/34 + - 8042/3 + - 8043/3 + - 8044/3 + - 8045/3 + - 8046/3 + - 8046/6 + - 8050/0 + - 8050/2 + - 8050/3 + - 8051/0 + - 8051/3 + - 8052/0 + - 8052/2 + - 8052/3 + - 8053/0 + - 8060/0 + - 8070/2 + - 8070/3 + - 8070/6 + - 8070/33 + - 8071/2 + - 8071/3 + - 8072/3 + - 8073/3 + - 8074/3 + - 8075/3 + - 8076/2 + - 8076/3 + - 8077/0 + - 8077/2 + - 8078/3 + - 8080/2 + - 8081/2 + - 8082/3 + - 8083/3 + - 8084/3 + - 8085/3 + - 8086/3 + - 8090/1 + - 8090/3 + - 8091/3 + - 8092/3 + - 8093/3 + - 8094/3 + - 8095/3 + - 8096/0 + - 8097/3 + - 8098/3 + - 8100/0 + - 8101/0 + - 8102/0 + - 8102/3 + - 8103/0 + - 8110/0 + - 8110/3 + - 8120/0 + - 8120/1 + - 8120/2 + - 8120/3 + - 8121/0 + - 8121/1 + - 8121/3 + - 8122/3 + - 8123/3 + - 8124/3 + - 8130/1 + - 8130/2 + - 8130/3 + - 8131/3 + - 8140/0 + - 8140/1 + - 8140/2 + - 8140/3 + - 8140/6 + - 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"_terms_enum.yaml#/99853/common" + 9986/3: + $ref: + - "_terms_enum.yaml#/99863/common" + 9987/3: + $ref: + - "_terms_enum.yaml#/99873/common" + 9989/3: + $ref: + - "_terms_enum.yaml#/99893/common" + 9991/3: + $ref: + - "_terms_enum.yaml#/99913/common" + 9992/3: + $ref: + - "_terms_enum.yaml#/99923/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + ovarian_specimen_status: + $ref: + - "_terms.yaml#/ovarian_specimen_status/common" + enum: + - Ovarian Capsule Fragmented + - Ovarian Capsule Intact + - Ovarian Capsule Ruptured + - Unknown + - Not Reported + enumDef: + Ovarian Capsule Fragmented: + $ref: + - "_terms_enum.yaml#/ovarian_capsule_fragmented/common" + Ovarian Capsule Intact: + $ref: + - "_terms_enum.yaml#/ovarian_capsule_intact/common" + Ovarian Capsule Ruptured: + $ref: + - "_terms_enum.yaml#/ovarian_capsule_ruptured/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + ovarian_surface_involvement: + $ref: + - "_terms.yaml#/ovarian_surface_involvement/common" + enum: + - Absent + - Indeterminate + - Present + - Unknown + - Not Reported + enumDef: + Absent: + $ref: + - "_terms_enum.yaml#/absent/common" + Indeterminate: + $ref: + - "_terms_enum.yaml#/indeterminate/common" + Present: + $ref: + - "_terms_enum.yaml#/present/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + papillary_renal_cell_type: + $ref: + - "_terms.yaml#/papillary_renal_cell_type/common" + enum: + - Type 1 + - Type 2 + enumDef: + Type 1: + $ref: + - "_terms_enum.yaml#/type_1/common" + Type 2: + $ref: + - "_terms_enum.yaml#/type_2/common" + + pediatric_kidney_staging: + $ref: + - "_terms.yaml#/pediatric_kidney_staging/common" + enum: + - Nephrectomy specimen with tumor confined to the kidney; distant metastasis + identified at diagnosis + - Nephrectomy specimen with tumor confined to the kidney; no distant metastasis + - Nephrectomy specimen with tumor that is present at the surgical margin of + resection or within regional lymph nodes; distant metastasis identified at + diagnosis + - Nephrectomy specimen with tumor that is present at the surgical margin of + resection or within regional lymph nodes; no distant metastasis + - Nephrectomy specimen with tumor that penetrates the renal capsule or involves + the renal sinus with negative margins and negative lymph nodes; distant metastasis + identified at diagnosis + - Nephrectomy specimen with tumor that penetrates the renal capsule or involves + the renal sinus with negative margins and negative lymph nodes; no distant + metastasis + - Tumor biopsied only at diagnosis; distant metastasis identified at diagnosis + - Tumor biopsied only at diagnosis; no distant metastasis + - Unknown + - Not Reported + + peritoneal_fluid_cytological_status: + $ref: + - "_terms.yaml#/peritoneal_fluid_cytological_status/common" + enum: + - Atypical + - Malignant + - Non-Malignant + - Unsatisfactory + - Unknown + - Not Reported + enumDef: + Atypical: + $ref: + - "_terms_enum.yaml#/atypical/common" + Malignant: + $ref: + - "_terms_enum.yaml#/malignant/common" + Non-Malignant: + $ref: + - "_terms_enum.yaml#/nonmalignant/common" + Unsatisfactory: + $ref: + - "_terms_enum.yaml#/unsatisfactory/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + pregnant_at_diagnosis: + $ref: + - "_terms.yaml#/pregnant_at_diagnosis/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + primary_diagnosis: + $ref: + - "_terms.yaml#/primary_diagnosis/common" + enum: + - Abdominal desmoid + - Abdominal fibromatosis + - Achromic nevus + - Acidophil adenocarcinoma + - Acidophil adenoma + - Acidophil carcinoma + - Acinar adenocarcinoma + - Acinar adenocarcinoma, sarcomatoid + - Acinar adenoma + - Acinar carcinoma + - Acinar cell adenoma + - Acinar cell carcinoma + - Acinar cell cystadenocarcinoma + - Acinar cell tumor + - Acinic cell adenocarcinoma + - Acinic cell adenoma + - Acinic cell tumor + - Acoustic neuroma + - Acquired cystic disease-associated renal cell carcinoma (RCC) + - Acquired tufted hemangioma + - Acral lentiginous melanoma, malignant + - ACTH-producing tumor + - Acute basophilic leukaemia + - Acute bilineal leukemia + - Acute biphenotypic leukemia + - Acute erythremia + - Acute erythremic myelosis + - Acute erythroid leukaemia + - Acute granulocytic leukemia + - Acute leukemia, Burkitt type + - Acute leukemia, NOS + - Acute lymphatic leukemia + - Acute lymphoblastic leukemia, L2 type, NOS + - Acute lymphoblastic leukemia, mature B-cell type + - Acute lymphoblastic leukemia, NOS + - Acute lymphoblastic leukemia, precursor cell type + - Acute lymphoblastic leukemia-lymphoma, NOS + - Acute lymphocytic leukemia + - Acute lymphoid leukemia + - Acute megakaryoblastic leukaemia + - Acute mixed lineage leukemia + - Acute monoblastic and monocytic leukemia + - Acute monoblastic leukemia + - Acute monocytic leukemia + - Acute myeloblastic leukemia + - Acute myelocytic leukemia + - Acute myelofibrosis + - Acute myelogenous leukemia + - Acute myeloid leukaemia, t(8;21)(q22;q22) + - Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 + - Acute myeloid leukemia with abnormal marrow eosinophils (includes all variants) + - Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1 + - Acute myeloid leukemia with maturation + - Acute myeloid leukemia with multilineage dysplasia + - Acute myeloid leukemia with mutated CEBPA + - Acute myeloid leukemia with mutated NPM1 + - Acute myeloid leukemia with myelodysplasia-related changes + - Acute myeloid leukemia with prior myelodysplastic syndrome + - Acute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214 + - Acute myeloid leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1 + - Acute myeloid leukemia with t(9;11)(p22;q23); MLLT3-MLL + - Acute myeloid leukemia without maturation + - Acute myeloid leukemia without prior myelodysplastic syndrome + - Acute myeloid leukemia, AML1(CBF-alpha)/ETO + - Acute myeloid leukemia, CBF-beta/MYH11 + - Acute myeloid leukemia, inv(16)(p13;q22) + - Acute myeloid leukemia, M6 type + - Acute myeloid leukemia, minimal differentiation + - Acute myeloid leukemia, MLL + - Acute myeloid leukemia, NOS + - Acute myeloid leukemia, PML/RAR-alpha + - Acute myeloid leukemia, t(15:17)(g22;q11-12) + - Acute myeloid leukemia, t(16;16)(p 13;q 11) + - Acute myelomonocytic leukemia + - Acute myelomonocytic leukemia with abnormal eosinophils + - Acute myelosclerosis, NOS + - Acute myloid leukemia, 11q23 abnormalities + - Acute non-lymphocytic leukemia + - Acute panmyelosis with myelofibrosis + - Acute panmyelosis, NOS + - Acute progressive histiocytosis X + - Acute promyelocytic leukaemia, PML-RAR-alpha + - Acute promyelocytic leukaemia, t(15;17)(q22;q11-12) + - Acute promyelocytic leukemia, NOS + - Adamantinoma of long bones + - Adamantinoma, malignant + - Adamantinoma, NOS + - Adenoacanthoma + - Adenoameloblastoma + - Adenocarcinoid tumor + - Adenocarcinoma admixed with neuroendocrine carcinoma + - Adenocarcinoma combined with other types of carcinoma + - Adenocarcinoma in a polyp, NOS + - Adenocarcinoma in adenomatous polyp + - Adenocarcinoma in adenomatous polyposis coli + - Adenocarcinoma in multiple adenomatous polyps + - Adenocarcinoma in polypoid adenoma + - Adenocarcinoma in situ in a polyp, NOS + - Adenocarcinoma in situ in adenomatous polyp + - Adenocarcinoma in situ in polypoid adenoma + - Adenocarcinoma in situ in tubular adenoma + - Adenocarcinoma in situ in tubulovillous adenoma + - Adenocarcinoma in situ in villous adenoma + - Adenocarcinoma in situ, mucinous + - Adenocarcinoma in situ, non-mucinous + - Adenocarcinoma in situ, NOS + - Adenocarcinoma in tubolovillous adenoma + - Adenocarcinoma in tubular adenoma + - Adenocarcinoma in tubulovillous adenoma + - Adenocarcinoma in villous adenoma + - Adenocarcinoma of anal ducts + - Adenocarcinoma of anal glands + - Adenocarcinoma of rete ovarii + - Adenocarcinoma with apocrine metaplasia + - Adenocarcinoma with cartilaginous and osseous metaplasia + - Adenocarcinoma with cartilaginous metaplasia + - Adenocarcinoma with mixed subtypes + - Adenocarcinoma with neuroendocrine differentiation + - Adenocarcinoma with osseous metaplasia + - Adenocarcinoma with spindle cell metaplasia + - Adenocarcinoma with squamous metaplasia + - Adenocarcinoma, cribriform comedo-type + - Adenocarcinoma, cylindroid + - Adenocarcinoma, diffuse type + - Adenocarcinoma, endocervical type + - Adenocarcinoma, intestinal type + - Adenocarcinoma, metastatic, NOS + - Adenocarcinoma, NOS + - Adenocarcinoma, pancreatobiliary type + - Adenocystic carcinoma + - Adenofibroma, NOS + - Adenoid basal carcinoma + - Adenoid cystic carcinoma + - Adenolipoma + - Adenolymphoma + - Adenoma of nipple + - Adenoma, NOS + - Adenomatoid odontogenic tumor + - Adenomatoid tumor, NOS + - Adenomatosis, NOS + - Adenomatous polyp, NOS + - Adenomatous polyposis coli + - Adenomyoepithelioma + - Adenomyoepithelioma with carcinoma + - Adenomyoma + - Adenosarcoma + - Adenosquamous carcinoma + - Adnexal carcinoma + - Adnexal tumor, benign + - Adrenal cortical adenocarcinoma + - Adrenal cortical adenoma, clear cell + - Adrenal cortical adenoma, compact cell + - Adrenal cortical adenoma, glomerulosa cell + - Adrenal cortical adenoma, mixed cell + - Adrenal cortical adenoma, NOS + - Adrenal cortical adenoma, pigmented + - Adrenal cortical carcinoma + - Adrenal cortical tumor, benign + - Adrenal cortical tumor, malignant + - Adrenal cortical tumor, NOS + - Adrenal medullary paraganglioma + - Adrenal medullary paraganglioma, malignant + - Adrenal rest tumor + - Adult cystic teratoma + - Adult granulosa cell tumor + - Adult rhabdomyoma + - Adult T-cell leukemia + - Adult T-cell leukemia/lymphoma (HTLV-1 positive) (includes all variants) + - Adult T-cell lymphoma + - Adult T-cell lymphoma/leukemia + - Adult teratoma, NOS + - Aggressive angiomyxoma + - Aggressive digital papillary adenoma + - Aggressive fibromatosis + - Aggressive NK-cell leukaemia + - Aggressive osteoblastoma + - Aggressive systemic mastocytosis + - Agnogenic myeloid metaplasia + - AIN III + - Aleukemic granulocytic leukemia + - Aleukemic leukemia, NOS + - Aleukemic lymphatic leukemia + - Aleukemic lymphocytic leukemia + - Aleukemic lymphoid leukemia + - Aleukemic monocytic leukemia + - Aleukemic myelogenous leukemia + - Aleukemic myeloid leukemia + - ALK positive large B-cell lymphoma + - Alpha cell tumor, malignant + - Alpha cell tumor, NOS + - Alpha heavy chain disease + - Alveolar adenocarcinoma + - Alveolar adenoma + - Alveolar carcinoma + - Alveolar cell carcinoma + - Alveolar rhabdomyosarcoma + - Alveolar soft part sarcoma + - Amelanotic melanoma + - Ameloblastic carcinoma + - Ameloblastic fibro-odontoma + - Ameloblastic fibro-odontosarcoma + - Ameloblastic fibrodentinoma + - Ameloblastic fibrodentinosarcoma + - Ameloblastic fibroma + - Ameloblastic fibrosarcoma + - Ameloblastic odontosarcoma + - Ameloblastic sarcoma + - Ameloblastoma, malignant + - Ameloblastoma, NOS + - AML M6 + - Anal intraepithelial neoplasia, grade III + - Anal intraepithelial neoplasia, low grade + - Anaplastic astrocytoma, IDH-mutant + - Anaplastic astrocytoma, IDH-wildtype + - Anaplastic large B-cell lymphoma + - Anaplastic large cell lymphoma, ALK negative + - Anaplastic large cell lymphoma, ALK positive + - Anaplastic large cell lymphoma, CD30+ + - Anaplastic large cell lymphoma, NOS + - Anaplastic large cell lymphoma, T cell and Null cell type + - Anaplastic medulloblastoma + - Anaplastic oligoastrocytoma + - Anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted + - Anaplastic pleomorphic xanthroastrocytoma + - Ancient schwannoma + - Androblastoma, benign + - Androblastoma, malignant + - Androblastoma, NOS + - Angioblastic meningioma + - Angioblastoma + - Angiocentric glioma + - Angiocentric immunoproliferative lesion + - Angiocentric T-cell lymphoma + - Angioendothelioma + - Angioendotheliomatosis + - Angiofibroma, NOS + - Angioimmunoblastic lymphadenopathy + - Angioimmunoblastic lymphoma + - Angioimmunoblastic T-cell lymphoma + - Angiokeratoma + - Angioleiomyoma + - Angiolipoma, NOS + - Angioma, NOS + - Angiomatoid fibrous histiocytoma + - Angiomatous meningioma + - Angiomyofibroblastoma + - Angiomyolipoma + - Angiomyoma + - Angiomyosarcoma + - Angiomyxoma + - Angiosarcoma + - Angiotropic lymphoma + - Aortic body paraganglioma + - Aortic body tumor + - Aorticopulmonary paraganglioma + - Apocrine adenocarcinoma + - Apocrine adenoma + - Apocrine cystadenoma + - Apudoma + - Argentaffinoma, malignant + - Argentaffinoma, NOS + - Arrhenoblastoma, benign + - Arrhenoblastoma, malignant + - Arrhenoblastoma, NOS + - Arteriovenous hemangioma + - Askin tumor + - Astroblastoma + - Astrocytic glioma + - Astrocytoma, anaplastic + - Astrocytoma, low grade + - Astrocytoma, NOS + - Astroglioma + - Atypical adenoma + - Atypical carcinoid tumor + - Atypical choroid plexus papilloma + - Atypical chronic myeloid leukemia, BCR/ABL negative + - Atypical chronic myeloid leukemia, Philadelphia chromosome (Ph1) negative + - Atypical fibrous histiocytoma + - Atypical fibroxanthoma + - Atypical follicular adenoma + - Atypical hyperplasia/Endometrioid intraepithelial neoplasm + - Atypical leiomyoma + - Atypical lipoma + - Atypical medullary carcinoma + - Atypical meningioma + - Atypical polypoid adenomyoma + - Atypical proliferating clear cell tumor + - Atypical proliferating serous tumor + - Atypical proliferative endometrioid tumor + - Atypical proliferative mucinous tumor + - Atypical proliferative papillary serous tumor + - Atypical teratoid/rhabdoid tumor + - B cell lymphoma, NOS + - B lymphoblastic leukemia/lymphoma with hyperdiploidy + - B lymphoblastic leukemia/lymphoma with hypodiploidy (Hypodiploid ALL) + - B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) + - B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32); IL3-IGH + - B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2); BCR-ABL1 + - B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) + - B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged + - B lymphoblastic leukemia/lymphoma, NOS + - B-ALL + - B-cell lymphocytic leukemia/small lymphocytic lymphoma + - B-cell lymphoma, unclassifiable, with features intermediate between diffuse + large B-cell lymphoma and Burkitt lymphoma + - B-cell lymphoma, unclassifiable, with features intermediate between diffuse + large B-cell lymphoma and classical Hodgkin lymphoma + - Balloon cell melanoma + - Balloon cell nevus + - BALT lymphoma + - Basal cell adenocarcinoma + - Basal cell adenoma + - Basal cell carcinoma, desmoplastic type + - Basal cell carcinoma, fibroepithelial + - Basal cell carcinoma, micronodular + - Basal cell carcinoma, morpheic + - Basal cell carcinoma, nodular + - Basal cell carcinoma, NOS + - Basal cell epithelioma + - Basal cell tumor + - Basaloid carcinoma + - Basaloid squamous cell carcinoma + - Basophil adenocarcinoma + - Basophil adenoma + - Basophil carcinoma + - Basosquamous carcinoma + - Bednar tumor + - Bellini duct carcinoma + - Benign cystic nephroma + - Benign fibrous histiocytoma + - Beta cell adenoma + - Beta cell tumor, malignant + - Bile duct adenocarcinoma + - Bile duct adenoma + - Bile duct carcinoma + - Bile duct cystadenocarcinoma + - Bile duct cystadenoma + - Biliary intraepithelial neoplasia, grade 3 + - Biliary intraepithelial neoplasia, high grade + - Biliary intraepithelial neoplasia, low grade + - Biliary papillomatosis + - Biphenotypic sinonasal sarcoma + - Bizarre leiomyoma + - Black adenoma + - Blast cell leukemia + - Blastic NK cell lymphoma + - Blastic plasmacytoid dendritic cell neoplasm + - Blastoma, NOS + - Blue nevus, malignant + - Blue nevus, NOS + - Botryoid sarcoma + - Bowen disease + - Breast implant-associated anaplastic large cell lymphoma + - Brenner tumor, borderline malignancy + - Brenner tumor, malignant + - Brenner tumor, NOS + - Brenner tumor, proliferating + - Bronchial adenoma, carcinoid + - Bronchial adenoma, cylindroid + - Bronchial adenoma, NOS + - Bronchial-associated lymphoid tissue lymphoma + - Bronchio-alveolar carcinoma, mixed mucinous and non-mucinous + - Bronchio-alveolar carcinoma, mucinous + - Bronchiolar adenocarcinoma + - Bronchiolar carcinoma + - Bronchiolo-alveolar adenocarcinoma, NOS + - Bronchiolo-alveolar carcinoma, Clara cell + - Bronchiolo-alveolar carcinoma, Clara cell and goblet cell type + - Bronchiolo-alveolar carcinoma, goblet cell type + - Bronchiolo-alveolar carcinoma, indeterminate type + - Bronchiolo-alveolar carcinoma, non-mucinous + - Bronchiolo-alveolar carcinoma, NOS + - Bronchiolo-alveolar carcinoma, type II pneumocyte and goblet cell type + - Bronchiolo-alveolar carcinoma; type II pneumocyte + - Brooke tumor + - Brown fat tumor + - Burkitt cell leukemia + - Burkitt lymphoma, NOS (Includes all variants) + - Burkitt tumor + - Burkitt-like lymphoma + - C cell carcinoma + - c-ALL + - Calcifying epithelial odontogenic tumor + - Calcifying epithelioma of Malherbe + - Calcifying nested epithelial stromal tumor + - Calcifying odontogenic cyst + - Canalicular adenoma + - Cancer + - Capillary hemangioma + - Capillary lymphangioma + - Carcinofibroma + - Carcinoid tumor of uncertain malignant potential + - Carcinoid tumor, argentaffin, malignant + - Carcinoid tumor, argentaffin, NOS + - Carcinoid tumor, NOS + - Carcinoid tumor, NOS, of appendix + - Carcinoid, NOS + - Carcinoid, NOS, of appendix + - Carcinoma in a polyp, NOS + - Carcinoma in adenomatous polyp + - Carcinoma in pleomorphic adenoma + - Carcinoma in situ in a polyp, NOS + - Carcinoma in situ in adenomatous polyp + - Carcinoma in situ, NOS + - Carcinoma showing thymus-like differentiation + - Carcinoma showing thymus-like element + - Carcinoma simplex + - Carcinoma with apocrine metaplasia + - Carcinoma with chondroid differentiation + - Carcinoma with neuroendocrine differentiation + - Carcinoma with osseous differentiation + - Carcinoma with osteoclast-like giant cells + - Carcinoma with other types mesenchymal differentiation + - Carcinoma with productive fibrosis + - Carcinoma, anaplastic, NOS + - Carcinoma, diffuse type + - Carcinoma, intestinal type + - Carcinoma, metastatic, NOS + - Carcinoma, NOS + - Carcinoma, undifferentiated, NOS + - Carcinomatosis + - Carcinosarcoma, embryonal + - Carcinosarcoma, NOS + - Carotid body paraganglioma + - Carotid body tumor + - Cartilaginous exostosis + - CASTLE + - Cavernous hemangioma + - Cavernous lymphangioma + - Cellular angiofibroma + - Cellular blue nevus + - Cellular ependymoma + - Cellular fibroma + - Cellular leiomyoma + - Cellular schwannoma + - Cementifying fibroma + - Cemento-ossifying fibroma + - Cementoblastoma, benign + - Cementoma, NOS + - Central neuroblastoma + - Central neurocytoma + - Central odontogenic fibroma + - Central osteosarcoma + - Central primitive neuroectodermal tumor, NOS + - Cerebellar liponeurocytoma + - Cerebellar sarcoma, NOS + - Ceruminous adenocarcinoma + - Ceruminous adenoma + - Ceruminous carcinoma + - Cervical intraepithelial neoplasia, grade III + - Cervical intraepithelial neoplasia, low grade + - Chemodectoma + - Chief cell adenoma + - Chloroma + - Cholangiocarcinoma + - Cholangioma + - Chondroblastic osteosarcoma + - Chondroblastoma, malignant + - Chondroblastoma, NOS + - Chondroid chordoma + - Chondroid lipoma + - Chondroid syringoma + - Chondroma, NOS + - Chondromatosis, NOS + - Chondromatous giant cell tumor + - Chondromyxoid fibroma + - Chondrosarcoma grade 2/3 + - Chondrosarcoma, NOS + - Chordoid glioma + - Chordoid glioma of third ventricle + - Chordoid meningioma + - Chordoma, NOS + - Chorioadenoma + - Chorioadenoma destruens + - Chorioangioma + - Choriocarcinoma combined with embryonal carcinoma + - Choriocarcinoma combined with other germ cell elements + - Choriocarcinoma combined with teratorna + - Choriocarcinoma, NOS + - Chorioepithelioma + - Chorionepithelioma + - Choroid plexus carcinoma + - Choroid plexus papilloma, anaplastic + - Choroid plexus papilloma, malignant + - Choroid plexus papilloma, NOS + - Chromaffin paraganglioma + - Chromaffin tumor + - Chromaffinoma + - Chromophobe adenocarcinoma + - Chromophobe adenoma + - Chromophobe carcinoma + - Chromophobe cell renal carcinoma + - Chronic eosinophilic leukemia, NOS + - Chronic erythremia + - Chronic granulocytic leukemia, BCR/ABL + - Chronic granulocytic leukemia, NOS + - Chronic granulocytic leukemia, Philadelphia chromosome (Ph1) positive + - Chronic granulocytic leukemia, t(9;22)(q34;q11) + - Chronic idiopathic myelofibrosis + - Chronic leukemia, NOS + - Chronic lymphatic leukemia + - Chronic lymphocytic leukemia + - Chronic lymphocytic leukemia, B-cell type (includes all variants of BCLL) + - Chronic lymphoid leukemia + - Chronic lymphoproliferative disorder of NK cells + - Chronic monocytic leukemia + - Chronic myelocytic leukemia, NOS + - Chronic myelogenous leukemia, BCR-ABL positive + - Chronic myelogenous leukemia, Philadelphia chromosome (Ph 1) positive + - Chronic myelogenous leukemia, t(9;22)(q34;q11) + - Chronic myeloid leukemia, NOS + - Chronic myelomonocytic leukemia in transformation + - Chronic myelomonocytic leukemia, NOS + - Chronic myelomonocytic leukemia, Type 1 + - Chronic myelomonocytic leukemia, Type II + - Chronic myeloproliferative disease, NOS + - Chronic myeloproliferative disorder + - Chronic neutrophilic leukemia + - CIN III with severe dysplasia + - Cin III, NOS + - Circumscribed arachnoidal cerebellar sarcoma + - Classical Hodgkin lymphoma, lymphocyte depletion, diffuse fibrosis + - Classical Hodgkin lymphoma, lymphocyte depletion, NOS + - Classical Hodgkin lymphoma, lymphocyte depletion, reticular + - Classical Hodgkin lymphoma, lymphocyte-rich + - Classical Hodgkin lymphoma, mixed cellularity, NOS + - Classical Hodgkin lymphoma, nodular sclerosis, cellular phase + - Classical Hodgkin lymphoma, nodular sclerosis, grade 1 + - Classical Hodgkin lymphoma, nodular sclerosis, grade 2 + - Classical Hodgkin lymphoma, nodular sclerosis, NOS + - Clear cell (glycogen-rich) urothelial carcinoma + - Clear cell adenocarcinofibroma + - Clear cell adenocarcinoma, mesonephroid + - Clear cell adenocarcinoma, NOS + - Clear cell adenofibroma + - Clear cell adenofibroma of borderline malignancy + - Clear cell adenoma + - Clear cell carcinoma + - Clear cell chondrosarcoma + - Clear cell cystadenocarcinofibroma + - Clear cell cystadenofibroma + - Clear cell cystadenofibroma of borderline malignancy + - Clear cell cystadenoma + - Clear cell cystic tumor of borderline malignancy + - Clear cell ependymoma + - Clear cell hidradenoma + - Clear cell meningioma + - Clear cell odontogenic carcinoma + - Clear cell odontogenic tumor + - Clear cell sarcoma of kidney + - Clear cell sarcoma, NOS + - Clear cell sarcoma, of tendons and aponeuroses + - Clear cell tumor, NOS + - Cloacogenic carcinoma + - CNS Embryonal tumor with rhabdoid features + - Codman tumor + - Collecting duct carcinoma + - Colloid adenocarcinoma + - Colloid adenoma + - Colloid carcinoma + - Columnar cell papilloma + - Combined carcinoid and adenocarcinoma + - Combined hepatocellular carcinoma and cholangiocarcinoma + - Combined large cell neuroendocrine carcinoma + - Combined small cell carcinoma + - Combined small cell-adenocarcinoma + - Combined small cell-large carcinoma + - Combined small cell-squamous cell carcinoma + - Combined/mixed carcinoid and adenocarcinoma + - Comedocarcinoma, noninfiltrating + - Comedocarcinoma, NOS + - Common ALL + - Common precursor B ALL + - Complete hydatidiform mole + - Complex odontoma + - Composite carcinoid + - Composite Hodgkin and non-Hodgkin lymphoma + - Compound nevus + - Compound odontoma + - Condylomatous carcinoma + - Congenital fibrosarcoma + - Congenital generalized fibromatosis + - Congenital peribronchial myofibroblastic tumor + - Conventional central osteosarcoma + - Cortical T ALL + - CPNET + - Craniopharyngioma + - Craniopharyngioma, adamantinomatous + - Craniopharyngioma, papillary + - Cribriform carcinoma in situ + - Cribriform carcinoma, NOS + - Cribriform comedo-type carcinoma + - Cutaneous histiocytoma, NOS + - Cutaneous lymphoma, NOS + - Cutaneous mastocytosis + - Cutaneous T-cell lymphoma, NOS + - Cylindrical cell carcinoma + - Cylindrical cell papilloma + - Cylindroma of skin + - Cylindroma, NOS + - Cyst-associated renal cell carcinoma + - Cystadenocarcinoma, NOS + - Cystadenofibroma, NOS + - Cystadenoma, NOS + - Cystic astrocytoma + - Cystic hygroma + - Cystic hypersecretory carcinoma + - Cystic lymphangioma + - Cystic mesothelioma, benign + - Cystic mesothelioma, NOS + - Cystic partially differentiated nephroblastoma + - Cystic teratoma, NOS + - Cystic tumor of atrio-ventricular node + - Cystoma, NOS + - Cystosarcoma phyllodes, benign + - Cystosarcoma phyllodes, malignant + - Cystosarcoma phyllodes, NOS + - Dabska tumor + - DCIS, comedo type + - DCIS, NOS + - DCIS, papillary + - Dedifferentiated chondrosarcoma + - Dedifferentiated chordoma + - Dedifferentiated liposarcoma + - Deep histiocytoma + - Degenerated schwannoma + - Dendritic cell sarcoma, NOS + - Dentinoma + - Dermal and epidermal nevus + - Dermal nevus + - Dermatofibroma lenticulare + - Dermatofibroma, NOS + - Dermatofibrosarcoma protuberans, NOS + - Dermatofibrosarcoma, NOS + - Dermoid cyst with malignant transformation + - Dermoid cyst with secondary tumor + - Dermoid cyst, NOS + - Dermoid, NOS + - Desmoid, NOS + - Desmoplastic fibroma + - Desmoplastic infantile astrocytoma + - Desmoplastic infantile ganglioglioma + - Desmoplastic medulloblastoma + - Desmoplastic melanoma, amelanotic + - Desmoplastic melanoma, malignant + - Desmoplastic mesothelioma + - Desmoplastic nodular medulloblastoma + - Desmoplastic small round cell tumor + - Di Guglielmo disease + - Differentiated penile intraepithelial neoplasia + - Differentiated-type vulvar intraepithelial neoplasia + - Diffuse astrocytoma + - Diffuse astrocytoma, IDH-mutant + - Diffuse astrocytoma, IDH-wildtype + - Diffuse astrocytoma, low grade + - Diffuse cutaneous mastocytosis + - Diffuse intraductal papillomatosis + - Diffuse intrinsic pontine glioma, H3 K27M-mutant + - Diffuse large B-cell lymphoma associated with chronic inflammation + - Diffuse large B-cell lymphoma, NOS + - Diffuse leptomeningeal glioneuronal tumor + - Diffuse melanocytosis + - Diffuse meningiomatosis + - Diffuse midline glioma, H3 K27M-mutant + - Diffuse Pediatric-type High Grade Glioma + - Digital papillary adenocarcinoma + - Diktyoma, benign + - Diktyoma, malignant + - DIN 3 + - Duct adenocarcinoma, NOS + - Duct adenoma, NOS + - Duct carcinoma, desmoplastic type + - Duct carcinoma, NOS + - Duct cell carcinoma + - Ductal carcinoma in situ, comedo type + - Ductal carcinoma in situ, cribriform type + - Ductal carcinoma in situ, micropapillary + - Ductal carcinoma in situ, NOS + - Ductal carcinoma in situ, papillary + - Ductal carcinoma in situ, solid type + - Ductal carcinoma, cribriform type + - Ductal carcinoma, NOS + - Ductal intraepithelial neoplasia 3 + - Ductal papilloma + - Dysembryoplastic neuroepithelial tumor + - Dysgerminoma + - Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) + - Dysplastic nevus + - EBV positive diffuse large B-cell lymphoma of the elderly + - EC cell carcinoid + - Ecchondroma + - Ecchondrosis + - Eccrine acrospiroma + - Eccrine adenocarcinoma + - Eccrine cystadenoma + - Eccrine dermal cylindroma + - Eccrine papillary adenocarcinoma + - Eccrine papillary adenoma + - Eccrine poroma + - Eccrine poroma, malignant + - Eccrine spiradenoma + - ECL cell carcinoid, malignant + - ECL cell carcinoid, NOS + - Ectomesenchymoma + - Ectopic hamartomatous thymoma + - Elastofibroma + - Embryonal adenocarcinoma + - Embryonal adenoma + - Embryonal carcinoma, infantile + - Embryonal carcinoma, NOS + - Embryonal carcinoma, polyembryonal type + - Embryonal hepatoma + - Embryonal rhabdomyosarcoma, NOS + - Embryonal rhabdomyosarcoma, pleomorphic + - Embryonal sarcoma + - Embryonal teratoma + - Embryonal tumor with multilayered rosettes C19MC-altered + - Embryonal tumor with multilayered rosettes, NOS + - Embryonal tumor with rhabdoid features + - Encapsulated follicular variant of papillary thyroid carcinoma, NOS (EFVPTC, + NOS) + - Encapsulated papillary carcinoma + - Encapsulated papillary carcinoma with invasion + - Enchondroma + - Endocervical adenocarcinoma usual type + - Endocrine adenomatosis + - Endocrine tumor, functioning, NOS + - Endodermal sinus tumor + - Endolymphatic stromal myosis + - Endometrial sarcoma, NOS + - Endometrial stromal nodule + - Endometrial stromal sarcoma, high grade + - Endometrial stromal sarcoma, low grade + - Endometrial stromal sarcoma, NOS + - Endometrial stromatosis + - Endometrioid adenocarcinoma, ciliated cell variant + - Endometrioid adenocarcinoma, NOS + - Endometrioid adenocarcinoma, secretory variant + - Endometrioid adenocarcinoma, villoglandular + - Endometrioid adenofibroma, borderline malignancy + - Endometrioid adenofibroma, malignant + - Endometrioid adenofibroma, NOS + - Endometrioid adenoma, borderline malignancy + - Endometrioid adenoma, NOS + - Endometrioid carcinoma with squamous differentiation + - Endometrioid carcinoma, NOS + - Endometrioid cystadenocarcinoma + - Endometrioid cystadenofibroma, borderline malignancy + - Endometrioid cystadenofibroma, malignant + - Endometrioid cystadenofibroma, NOS + - Endometrioid cystadenoma, borderline malignancy + - Endometrioid cystadenoma, NOS + - Endometrioid tumor of low malignant potential + - Endotheliomatous meningioma + - Endovascular papillary angioendothelioma + - Enteric adenocarcinoma + - Enterochromaffin cell carcinoid + - Enterochromaffin-like cell carcinoid, NOS + - Enterochromaffin-like cell tumor, malignant + - Enteroglucagonoma, malignant + - Enteroglucagonoma, NOS + - Enteropathy associated T-cell lymphoma + - Enteropathy type intestinal T-cell lymphoma + - Eosinophil adenocarcinoma + - Eosinophil adenoma + - Eosinophil carcinoma + - Eosinophilic granuloma + - Eosinophilic leukemia + - Ependymoblastoma + - Ependymoma, anaplastic + - Ependymoma, NOS + - Ependymoma, RELA fusion-positive + - Epidermoid carcinoma in situ with questionable stromal invasion + - Epidermoid carcinoma in situ, NOS + - Epidermoid carcinoma, keratinizing + - Epidermoid carcinoma, large cell, nonkeratinizing + - Epidermoid carcinoma, NOS + - Epidermoid carcinoma, small cell, nonkeratinizing + - Epidermoid carcinoma, spindle cell + - Epithelial ependymoma + - Epithelial tumor, benign + - Epithelial tumor, malignant + - Epithelial-myoepithelial carcinoma + - Epithelioid and spindle cell nevus + - Epithelioid cell melanoma + - Epithelioid cell nevus + - Epithelioid cell sarcoma + - Epithelioid glioblastoma + - Epithelioid hemangioendothelioma, malignant + - Epithelioid hemangioendothelioma, NOS + - Epithelioid hemangioma + - Epithelioid leiomyoma + - Epithelioid leiomyosarcoma + - Epithelioid malignant peripheral nerve sheath tumor + - Epithelioid mesothelioma, benign + - Epithelioid mesothelioma, malignant + - Epithelioid mesothelioma, NOS + - Epithelioid MPNST + - Epithelioid sarcoma + - Epithelioma adenoides cysticum + - Epithelioma, benign + - Epithelioma, malignant + - Epithelioma, NOS + - Erythremic myelosis, NOS + - Erythroleukemia + - Esophageal glandular dysplasia (intraepithelial neoplasia), high grade + - Esophageal glandular dysplasia (intraepithelial neoplasia), low grade + - Esophageal intraepithelial neoplasia, high grade + - Esophageal squamous intraepithelial neoplasia (dysplasia), high grade + - Esophageal squamous intraepithelial neoplasia (dysplasia), low grade + - Essential hemorrhagic thrombocythaemia + - Essential thrombocythemia + - Esthesioneuroblastoma + - Esthesioneurocytoma + - Esthesioneuroepithelioma + - Ewing sarcoma + - Ewing tumor + - Extra-abdominal desmoid + - Extra-adrenal paraganglioma, malignant + - Extra-adrenal paraganglioma, NOS + - Extracutaneous mastocytoma + - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue + - Extranodal NK/T-cell lymphoma, nasal type + - Extraosseous plasmacytoma + - Extraventricular neurocytoma + - FAB L2 + - FAB L3 + - FAB Ll + - FAB M1 + - FAB M2, AML1(CBF-alpha)/ETO + - FAB M2, NOS + - FAB M2, t(8;21)(q22;q22) + - FAB M3 (includes all variants) + - FAB M4 + - FAB M4Eo + - FAB M5 (includes all variants) + - FAB M6 + - FAB M7 + - FAB MO + - Familial polyposis coli + - Fascial fibroma + - Fascial fibrosarcoma + - Fetal adenocarcinoma + - Fetal adenoma + - Fetal fat cell lipoma + - Fetal lipoma, NOS + - Fetal lipomatosis + - Fetal rhabdomyoma + - Fibrillary astrocytoma + - Fibro-osteoma + - Fibroadenoma, NOS + - Fibroameloblastic odontoma + - Fibroblastic liposarcoma + - Fibroblastic meningioma + - Fibroblastic osteosarcoma + - Fibroblastic reticular cell tumor + - Fibrochondrosarcoma + - Fibroepithelial basal cell carcinoma, Pinkus type + - Fibroepithelioma of Pinkus type + - Fibroepithelioma, NOS + - Fibrofolliculoma + - Fibroid uterus + - Fibrolipoma + - Fibroliposarcoma + - Fibroma, NOS + - Fibromatosis-like metaplastic carcinoma + - Fibromyoma + - Fibromyxolipoma + - Fibromyxoma + - Fibromyxosarcoma + - Fibrosarcoma, NOS + - Fibrosarcomatous dermatofibrosarcoma protuberans + - Fibrous astrocytoma + - Fibrous histiocytoma of tendon sheath + - Fibrous histiocytoma, NOS + - Fibrous meningioma + - Fibrous mesothelioma, benign + - Fibrous mesothelioma, malignant + - Fibrous mesothelioma, NOS + - Fibrous papule of nose + - Fibroxanthoma, malignant + - Fibroxanthoma, NOS + - Flat adenoma + - Flat intraepithelial glandular neoplasia, high grade + - Flat intraepithelial neoplasia, high grade + - Florid osseous dysplasia + - Follicular adenocarcinoma, moderately differentiated + - Follicular adenocarcinoma, NOS + - Follicular adenocarcinoma, trabecular + - Follicular adenocarcinoma, well differentiated + - Follicular adenoma + - Follicular adenoma, oxyphilic cell + - Follicular carcinoma, encapsulated + - Follicular carcinoma, minimally invasive + - Follicular carcinoma, moderately differentiated + - Follicular carcinoma, NOS + - Follicular carcinoma, oxyphilic cell + - Follicular carcinoma, trabecular + - Follicular carcinoma, well differentiated + - Follicular dendritic cell sarcoma + - Follicular dendritic cell tumor + - Follicular fibroma + - Follicular lymphoma, grade 1 + - Follicular lymphoma, grade 2 + - Follicular lymphoma, grade 3 + - Follicular lymphoma, grade 3A + - Follicular lymphoma, grade 3B + - Follicular lymphoma, NOS + - Follicular lymphoma, small cleaved cell + - Follicular thyroid carcinoma (FTC), encapsulated angioinvasive + - Folliculome lipidique + - Franklin disease + - G cell tumor, malignant + - G cell tumor, NOS + - Gamma heavy chain disease + - Gangliocytic paraganglioma + - Gangliocytoma + - Ganglioglioma, anaplastic + - Ganglioglioma, NOS + - Ganglioneuroblastoma + - Ganglioneuroma + - Ganglioneuromatosis + - GANT + - Gastrin cell tumor + - Gastrin cell tumor, malignant + - Gastrinoma, malignant + - Gastrinoma, NOS + - Gastrointestinal autonomic nerve tumor + - Gastrointestinal pacemaker cell tumor + - Gastrointestinal stromal sarcoma + - Gastrointestinal stromal tumor, benign + - Gastrointestinal stromal tumor, malignant + - Gastrointestinal stromal tumor, NOS + - Gastrointestinal stromal tumor, uncertain malignant potential + - Gelatinous adenocarcinoma + - Gelatinous carcinoma + - Gemistocytic astrocytoma + - Gemistocytoma + - Genital rhabdomyoma + - Germ cell tumor, nonseminomatous + - Germ cell tumor, NOS + - Germ cell tumors with associated hematological malignancy + - Germinoma + - Ghost cell odontogenic carcinoma + - Giant cell and spindle cell carcinoma + - Giant cell angiofibroma + - Giant cell carcinoma + - Giant cell fibroblastoma + - Giant cell glioblastoma + - Giant cell sarcoma + - Giant cell sarcoma of bone + - Giant cell tumor of bone, malignant + - Giant cell tumor of bone, NOS + - Giant cell tumor of soft parts, NOS + - Giant cell tumor of tendon sheath + - Giant cell tumor of tendon sheath, malignant + - Giant fibroadenoma + - Giant osteoid osteoma + - Giant pigmented nevus, NOS + - Gigantiform cementoma + - GIST, benign + - GIST, malignant + - GIST, NOS + - Glandular intraepithelial neoplasia, grade I + - Glandular intraepithelial neoplasia, grade II + - Glandular intraepithelial neoplasia, grade III + - Glandular intraepithelial neoplasia, high grade + - Glandular intraepithelial neoplasia, low grade + - Glandular papilloma + - Glassy cell carcinoma + - Glioblastoma + - Glioblastoma multiforme + - Glioblastoma with sarcomatous component + - Glioblastoma, IDH wildtype + - Glioblastoma, IDH-mutant + - Gliofibroma + - Glioma, malignant + - Glioma, NOS + - Gliomatosis cerebri + - Glioneuroma + - Gliosarcoma + - Glomangioma + - Glomangiomyoma + - Glomangiosarcoma + - Glomoid sarcoma + - Glomus jugulare tumor, NOS + - Glomus tumor, malignant + - Glomus tumor, NOS + - Glucagon-like peptide-producing tumor + - Glucagonoma, malignant + - Glucagonoma, NOS + - Glycogen-rich carcinoma + - Glycogenic rhabdomyoma + - Goblet cell carcinoid + - Gonadal stromal tumor, NOS + - Gonadoblastoma + - Gonocytoma + - Granular cell adenocarcinoma + - Granular cell carcinoma + - Granular cell myoblastoma, malignant + - Granular cell myoblastoma, NOS + - Granular cell tumor of the sellar region + - Granular cell tumor, malignant + - Granular cell tumor, NOS + - Granulocytic leukemia, NOS + - Granulocytic sarcoma + - Granulosa cell carcinoma + - Granulosa cell tumor, adult type + - Granulosa cell tumor, juvenile + - Granulosa cell tumor, malignant + - Granulosa cell tumor, NOS + - Granulosa cell tumor, sarcomatoid + - Granulosa cell-theca cell tumor + - Grawitz tumor + - Gynandroblastoma + - Haemangioblastoma + - Haemangiosarcoma + - Hairy cell leukemia + - Hairy cell leukemia variant + - Hairy nevus + - Halo nevus + - Hand-Schuller-Christian disease + - Heavy chain disease, NOS + - Hemangioblastic meningioma + - Hemangioendothelial sarcoma + - Hemangioendothelioma, benign + - Hemangioendothelioma, malignant + - Hemangioendothelioma, NOS + - Hemangioma simplex + - Hemangioma, NOS + - Hemangiopericytic meningioma + - Hemangiopericytoma, benign + - Hemangiopericytoma, malignant + - Hemangiopericytoma, NOS + - Hemolymphangioma + - Hepatoblastoma + - Hepatoblastoma, epithelioid + - Hepatoblastoma, mixed epithelial-mesenchymal + - Hepatocarcinoma + - Hepatocellular adenoma + - Hepatocellular carcinoma, clear cell type + - Hepatocellular carcinoma, fibrolamellar + - Hepatocellular carcinoma, NOS + - Hepatocellular carcinoma, pleomorphic type + - Hepatocellular carcinoma, sarcomatoid + - Hepatocellular carcinoma, scirrhous + - Hepatocellular carcinoma, spindle cell variant + - Hepatocholangiocarcinoma + - Hepatoid adenocarcinoma + - Hepatoid carcinoma + - Hepatoid yolk sac tumor + - Hepatoma, benign + - Hepatoma, malignant + - Hepatoma, NOS + - Hepatosplenic gamma-delta cell lymphoma + - Hepatosplenic T-cell lymphoma + - Hereditary leiomyomatosis & RCC-associated renal cell carcinoma + - Hibernoma + - Hidradenocarcinoma + - Hidradenoma papilliferum + - Hidradenoma, NOS + - Hidrocystoma + - High grade surface osteosarcoma + - High-grade neuroendocrine carcinoma + - High-grade serous carcinoma + - Hilar cell tumor + - Hilus cell tumor + - Histiocyte-rich large B-cell lymphoma + - Histiocytic medullary reticulosis + - Histiocytic sarcoma + - Histiocytoid hemangioma + - Histiocytoma, NOS + - Histiocytosis X, NOS + - Hodgkin disease, lymphocyte predominance, diffuse + - Hodgkin disease, lymphocyte predominance, NOS + - Hodgkin disease, lymphocytic-histiocytic predominance + - Hodgkin disease, nodular sclerosis, lymphocyte depletion + - Hodgkin disease, nodular sclerosis, lymphocyte predominance + - Hodgkin disease, nodular sclerosis, mixed cellularity + - Hodgkin disease, nodular sclerosis, NOS + - Hodgkin disease, nodular sclerosis, syncytial variant + - Hodgkin disease, NOS + - Hodgkin granuloma + - Hodgkin lymphoma, lymphocyte depletion, diffuse fibrosis + - Hodgkin lymphoma, lymphocyte depletion, NOS + - Hodgkin lymphoma, lymphocyte depletion, reticular + - Hodgkin lymphoma, lymphocyte predominance, nodular + - Hodgkin lymphoma, lymphocyte-rich + - Hodgkin lymphoma, mixed cellularity, NOS + - Hodgkin lymphoma, nodular lymphocyte predominance + - Hodgkin lymphoma, nodular sclerosis, cellular phase + - Hodgkin lymphoma, nodular sclerosis, grade 1 + - Hodgkin lymphoma, nodular sclerosis, grade 2 + - Hodgkin lymphoma, nodular sclerosis, NOS + - Hodgkin lymphoma, NOS + - Hodgkin paragranuloma, nodular + - Hodgkin paragranuloma, NOS + - Hodgkin sarcoma + - Hurthle cell adenocarcinoma + - Hurthle cell adenoma + - Hurthle cell carcinoma + - Hurthle cell tumor + - Hutchinson melanotic freckle, NOS + - Hyalinizing trabecular adenoma + - Hydatid mole + - Hydatidiform mole, NOS + - Hydroa vacciniforme-like lymphoma + - Hygroma, NOS + - Hypereosinophilic syndrome + - Hypernephroid tumor + - Hypernephroma + - Idiopathic hemorrhagic thrombocythaemia + - Idiopathic thrombocythemia + - Immature teratoma, malignant + - Immature teratoma, NOS + - Immunoblastic sarcoma + - Immunocytoma + - Immunoglobulin deposition disease + - Immunoproliferative disease, NOS + - Immunoproliferative small intestinal disease + - Indeterminate dendritic cell tumor + - Indolent systemic mastocytosis + - Indolent T-cell lymphoproliferative disorder of gastrointestinal tract + - Infantile fibrosarcoma + - Infantile hemangioma + - Infantile myofibromatosis + - Infiltrating and papillary adenocarcinoma + - Infiltrating angiolipoma + - Infiltrating basal cell carcinoma, non-sclerosing + - Infiltrating basal cell carcinoma, NOS + - Infiltrating basal cell carcinoma, sclerosing + - Infiltrating duct adenocarcinoma + - Infiltrating duct and colloid carcinoma + - Infiltrating duct and cribriform carcinoma + - Infiltrating duct and lobular carcinoma + - Infiltrating duct and lobular carcinoma in situ + - Infiltrating duct and mucinous carcinoma + - Infiltrating duct and tubular carcinoma + - Infiltrating duct carcinoma, NOS + - Infiltrating duct mixed with other types of carcinoma + - Infiltrating ductular carcinoma + - Infiltrating lipoma + - Infiltrating lobular carcinoma and ductal carcinoma in situ + - Infiltrating lobular carcinoma, NOS + - Infiltrating lobular mixed with other types of carcinoma + - Infiltrating papillary adenocarcinoma + - Inflammatory adenocarcinoma + - Inflammatory carcinoma + - Inflammatory liposarcoma + - Inflammatory myofibroblastic tumor + - Insular carcinoma + - Insulinoma, malignant + - Insulinoma, NOS + - Interdigitating cell sarcoma + - Interdigitating dendritic cell sarcoma + - Intermediate and giant congenital nevus + - Interstitial cell tumor, benign + - Interstitial cell tumor, malignant + - Interstitial cell tumor, NOS + - Intestinal T-cell lymphoma + - Intestinal-type adenocarcinoma + - Intimal sarcoma + - Intracanalicular fibroadenoma + - Intracortical osteosarcoma + - Intracystic carcinoma, NOS + - Intracystic papillary adenocarcinoma + - Intracystic papillary adenoma + - Intracystic papillary neoplasm with associated invasive carcinoma + - Intracystic papillary neoplasm with high grade intraepithelial neoplasia + - Intracystic papillary neoplasm with intermediate grade intraepithelial neoplasia + - Intracystic papillary neoplasm with low grade intraepithelial neoplasia + - Intracystic papillary tumor with high grade dysplasia + - Intracystic papillary tumor with high grade entraepithelial neoplasia + - Intracystic papillary tumor with high grade intraepithelial neoplasia + - Intracystic papilloma + - Intradermal nevus + - Intraductal adenocarcinoma, noninfiltrating, NOS + - Intraductal and lobular carcinoma + - Intraductal carcinoma and lobular carcinoma in situ + - Intraductal carcinoma, clinging + - Intraductal carcinoma, noninfiltrating, NOS + - Intraductal carcinoma, NOS + - Intraductal carcinoma, solid type + - Intraductal micropapillary carcinoma + - Intraductal papillary adenocarcinoma with invasion + - Intraductal papillary adenocarcinoma, NOS + - Intraductal papillary carcinoma + - Intraductal papillary mucinous neoplasm (IPMN) with an associated invasive + carcinoma + - Intraductal papillary mucinous neoplasm with an associated invasive carcinoma + - Intraductal papillary mucinous neoplasm with high grade dysplasia + - Intraductal papillary neoplasm with associated invasive carcinoma + - Intraductal papillary neoplasm with high grade dysplasia + - Intraductal papillary neoplasm with high grade intraepithelial neoplasia + - Intraductal papillary neoplasm with intermediate grade neoplasia + - Intraductal papillary neoplasm with low grade intraepithelial neoplasia + - Intraductal papillary neoplasm, NOS + - Intraductal papillary tumor with high grade dysplasia + - Intraductal papillary tumor with high grade intraepithelial neoplasia + - Intraductal papillary-mucinous adenoma + - Intraductal papillary-mucinous carcinoma, invasive + - Intraductal papillary-mucinous carcinoma, non-invasive + - Intraductal papillary-mucinous neoplasm with low grade dysplasia + - Intraductal papillary-mucinous neoplasm with moderate dysplasia + - Intraductal papillary-mucinous tumor with intermediate dysplasia + - Intraductal papillary-mucinous tumor with low grade dysplasia + - Intraductal papillary-mucinous tumor with moderate dysplasia + - Intraductal papilloma + - Intraductal papilloma with ductal carcinoma in situ + - Intraductal papilloma with lobular carcinoma in situ + - Intraductal papillomatosis, NOS + - Intraductal tubular-papillary neoplasm, high grade + - Intraductal tubular-papillary neoplasm, low grade + - Intraductal tubulopapillary neoplasm + - Intraepidermal carcinoma, NOS + - Intraepidermal epithelioma of Jadassohn + - Intraepidermal nevus + - Intraepidermal squamous cell carcinoma, Bowen type + - Intraepithelial carcinoma, NOS + - Intraepithelial squamous cell carcinoma + - Intraglandular papillary neoplasm with low grade intraepithelial neoplasia + - Intramuscular hemangioma + - Intramuscular lipoma + - Intraneural perineurioma + - Intraosseous low grade osteosarcoma + - Intraosseous well differentiated osteosarcoma + - Intratubular germ cell neoplasia + - Intratubular malignant germ cells + - Intravascular B-cell lymphoma + - Intravascular bronchial alveolar tumor + - Intravascular large B-cell lymphoma + - Intravascular leiomyomatosis + - Invasive carcinoma of no special type + - Invasive carcinoma, NST + - Invasive encapsulated follicular variant of papillary thyroid carcinoma (invasive + EFVPTC) + - Invasive fibroma + - Invasive hydatidiform mole + - Invasive lobular carcinoma + - Invasive lobular carcinoma, alveolar type + - Invasive lobular carcinoma, solid type + - Invasive lobular carcinoma, tubulolobular variant + - Invasive mammary carcinoma + - Invasive micropapillary carcinoma + - Invasive mole, NOS + - Invasive mucinous adenocarcinoma + - Involuting nevus + - Islet cell adenocarcinoma + - Islet cell adenoma + - Islet cell adenomatosis + - Islet cell carcinoma + - Islet cell tumor, benign + - Islet cell tumor, NOS + - Jadassohn blue nevus + - Jugular paraganglioma + - Jugulotympanic paraganglioma + - Junction nevus + - Junctional nevus, NOS + - Juvenile angiofibroma + - Juvenile astrocytoma + - Juvenile carcinoma of breast + - Juvenile chronic myelomonocytic leukemia + - Juvenile fibroadenoma + - Juvenile hemangioma + - Juvenile histiocytoma + - Juvenile melanoma + - Juvenile myelomonocytic leukemia + - Juvenile nevus + - Juxtacortical chondroma + - Juxtacortical chondrosarcoma + - Juxtacortical osteosarcoma + - Juxtaglomerular tumor + - Kaposi sarcoma + - Kaposiform hemangioendothelioma + - Keratotoc papilloma + - Klatskin tumor + - Krukenberg tumor + - Kupffer cell sarcoma + - L-cell tumor + - Lactating adenoma + - Langerhans cell granulomatosis + - Langerhans cell granulomatosis, unifocal + - Langerhans cell histiocytosis, disseminated + - Langerhans cell histiocytosis, generalized + - Langerhans cell histiocytosis, mono-ostotic + - Langerhans cell histiocytosis, multifocal + - Langerhans cell histiocytosis, NOS + - Langerhans cell histiocytosis, poly-ostotic + - Langerhans cell histiocytosis, unifocal + - Langerhans cell sarcoma + - Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease + - Large cell (Ki-1+) lymphoma + - Large cell calcifying Sertoli cell tumor + - Large cell carcinoma with rhabdoid phenotype + - Large cell carcinoma, NOS + - Large cell medulloblastoma + - Large cell neuroendocrine carcinoma + - Large granular lymphocytosis, NOS + - LCIS, NOS + - Leiomyoblastoma + - Leiomyofibroma + - Leiomyoma, NOS + - Leiomyomatosis, NOS + - Leiomyosarcoma, NOS + - Lennert lymphoma + - Lentigo maligna + - Lentigo maligna melanoma + - Lepidic adenocarcinoma + - Lepidic predominant adenocarcinoma + - Leptomeningeal sarcoma + - Letterer-Siwe disease + - Leukemia, NOS + - Leukemic reticuloendotheliosis + - Leydig cell tumor, benign + - Leydig cell tumor, malignant + - Leydig cell tumor, NOS + - Linitis plastica + - Lipid cell tumor of ovary + - Lipid-rich carcinoma + - Lipid-rich Sertoli cell tumor + - Lipid-rich urothelial carcinoma + - Lipoadenoma + - Lipoblastoma + - Lipoblastomatosis + - Lipoid cell tumor of ovary + - Lipoleiomyoma + - Lipoma, NOS + - Lipoma-like liposarcoma + - Lipomatous medulloblastoma + - Liposarcoma, differentiated + - Liposarcoma, NOS + - Liposarcoma, well differentiated + - Liver cell adenoma + - Liver cell carcinoma + - Lobular adenocarcinoma + - Lobular and ductal carcinoma + - Lobular carcinoma in situ, NOS + - Lobular carcinoma, noninfiltrating + - Lobular carcinoma, NOS + - Localized fibrous tumor + - Low grade adenosquamous carcinoma + - Low grade appendiceal mucinous neoplasm + - Low grade cribriform cystadenocarcinoma (LGCCC) + - Low-grade central osteosarcoma + - Low-grade fibromyxoid sarcoma + - Low-grade intramedullary osteosarcoma + - Low-grade myofibroblastic sarcoma + - Low-grade serous carcinoma + - Luteinoma + - Luteoma, NOS + - Lymphangioendothelial sarcoma + - Lymphangioendothelioma, malignant + - Lymphangioendothelioma, NOS + - Lymphangioleiomyomatosis + - Lymphangioma, NOS + - Lymphangiomyoma + - Lymphangiomyomatosis + - Lymphangiosarcoma + - Lymphatic leukemic, NOS + - Lymphoblastic leukemia, NOS + - Lymphoblastoma + - Lymphocytic leukemia, NOS + - Lymphoepithelial carcinoma + - Lymphoepithelioid lymphoma + - Lymphoepithelioma + - Lymphoepithelioma-like carcinoma + - Lymphoid leukemia, NOS + - Lymphoma, NOS + - Lymphomatoid granulomatosis + - Lymphomatoid papulosis + - Lymphoplasmacyte-rich meningioma + - Lymphoproliferative disease, NOS + - Lymphoproliferative disorder, NOS + - Lymphosarcoma cell leukemia + - Lymphosarcoma, diffuse + - Lymphosarcoma, NOS + - M6A + - M6B + - Macrofollicular adenoma + - Magnocellular nevus + - Malignancy + - Malignant chondroid syringoma + - Malignant cystic nephroma + - Malignant eccrine spiradenoma + - Malignant fibrous histiocytoma + - Malignant fibrous histiocytoma (MFH) of bone + - Malignant giant cell tumor of soft parts + - Malignant histiocytosis + - Malignant hydatidiform mole + - Malignant lymphoma, centroblastic, diffuse + - Malignant lymphoma, centroblastic, follicular + - Malignant lymphoma, centroblastic, NOS + - Malignant lymphoma, centroblasticcentrocytic, diffuse + - Malignant lymphoma, centroblasticcentrocytic, follicular + - Malignant lymphoma, centroblasticcentrocytic, NOS + - Malignant lymphoma, centrocytic + - Malignant lymphoma, cleaved cell, NOS + - Malignant lymphoma, convoluted cell + - Malignant lymphoma, diffuse, NOS + - Malignant lymphoma, follicle center, follicular + - Malignant lymphoma, follicle center, NOS + - Malignant lymphoma, follicular, NOS + - Malignant lymphoma, histiocytic, diffuse + - Malignant lymphoma, histiocytic, nodular + - Malignant lymphoma, histiocytic, NOS + - Malignant lymphoma, Hodgkin + - Malignant lymphoma, immunoblastic, NOS + - Malignant lymphoma, large B-cell, diffuse, centroblastic, NOS + - Malignant lymphoma, large B-cell, diffuse, immunoblastic, NOS + - Malignant lymphoma, large B-cell, diffuse, NOS + - Malignant lymphoma, large B-cell, NOS + - Malignant lymphoma, large cell, cleaved and noncleaved + - Malignant lymphoma, large cell, cleaved, diffuse + - Malignant lymphoma, large cell, cleaved, NOS + - Malignant lymphoma, large cell, diffuse, NOS + - Malignant lymphoma, large cell, follicular, NOS + - Malignant lymphoma, large cell, immunoblastic + - Malignant lymphoma, large cell, noncleaved, diffuse + - Malignant lymphoma, large cell, noncleaved, follicular + - Malignant lymphoma, large cell, noncleaved, NOS + - Malignant lymphoma, large cell, NOS + - Malignant lymphoma, large cleaved cell, follicular + - Malignant lymphoma, large cleaved cell, NOS + - Malignant lymphoma, lymphoblastic, NOS + - Malignant lymphoma, lymphocytic, diffuse, NOS + - Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse + - Malignant lymphoma, lymphocytic, intermediate differentiation, nodular + - Malignant lymphoma, lymphocytic, nodular, NOS + - Malignant lymphoma, lymphocytic, NOS + - Malignant lymphoma, lymphocytic, poorly differentiated, diffuse + - Malignant lymphoma, lymphocytic, poorly differentiated, nodular + - Malignant lymphoma, lymphocytic, well differentiated, diffuse + - Malignant lymphoma, lymphocytic, well differentiated, nodular + - Malignant lymphoma, lymphoplasmacytic + - Malignant lymphoma, lymphoplasmacytoid + - Malignant lymphoma, mixed cell type, diffuse + - Malignant lymphoma, mixed cell type, follicular + - Malignant lymphoma, mixed cell type, nodular + - Malignant lymphoma, mixed lymphocytic-histiocytic, diffuse + - Malignant lymphoma, mixed lymphocytic-histiocytic, nodular + - Malignant lymphoma, mixed small and large cell, diffuse + - Malignant lymphoma, mixed small cleaved and large cell, follicular + - Malignant lymphoma, nodular, NOS + - Malignant lymphoma, non-cleaved cell, NOS + - Malignant lymphoma, non-Hodgkin, NOS + - Malignant lymphoma, noncleaved cell, follicular, NOS + - Malignant lymphoma, noncleaved, diffuse, NOS + - Malignant lymphoma, noncleaved, NOS + - Malignant lymphoma, NOS + - Malignant lymphoma, plasmacytoid + - Malignant lymphoma, small B lymphocytic, NOS + - Malignant lymphoma, small cell diffuse + - Malignant lymphoma, small cell, noncleaved, diffuse + - Malignant lymphoma, small cell, NOS + - Malignant lymphoma, small cleaved cell, diffuse + - Malignant lymphoma, small cleaved cell, follicular + - Malignant lymphoma, small cleaved cell, NOS + - Malignant lymphoma, small lymphocytic, diffuse + - Malignant lymphoma, small lymphocytic, NOS + - Malignant lymphoma, small noncleaved, Burkitt type + - Malignant lymphoma, undifferentiated cell type, NOS + - Malignant lymphoma, undifferentiated cell, non-Burkitt + - Malignant lymphoma, undifferentiated, Burkitt type + - Malignant lymphomatous polyposis + - Malignant mast cell tumor + - Malignant mastocytoma + - Malignant mastocytosis + - Malignant melanoma in congenital melanocytic nevus + - Malignant melanoma in giant pigmented nevus + - Malignant melanoma in Hutchinson melanotic freckle + - Malignant melanoma in junctional nevus + - Malignant melanoma in precancerous melanosis + - Malignant melanoma, NOS + - Malignant melanoma, regressing + - Malignant midline reticulosis + - Malignant mucinous adenofibroma + - Malignant mucinous cystadenofibroma + - Malignant multilocular cystic nephroma + - Malignant myelosclerosis + - Malignant myoepithelioma + - Malignant peripheral nerve sheath tumor + - Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation + - Malignant perivascular epithelial cell tumor + - Malignant reticulosis, NOS + - Malignant rhabdoid tumor + - Malignant schwannoma with rhabdomyoblastic differentiation + - Malignant schwannoma, NOS + - Malignant serous adenofibroma + - Malignant serous cystadenofibroma + - Malignant tenosynovial giant cell tumor + - Malignant teratoma, anaplastic + - Malignant teratoma, intermediate + - Malignant teratoma, trophoblastic + - Malignant teratoma, undifferentiated + - Malignant tumor, clear cell type + - Malignant tumor, fusiform cell type + - Malignant tumor, giant cell type + - Malignant tumor, small cell type + - Malignant tumor, spindle cell type + - MALT lymphoma + - Mammary carcinoma, in situ + - MANEC + - Mantle cell lymphoma (Includes all variants blastic, pleomorphic, small cell) + - Mantle zone lymphoma + - Marginal zone B-cell lymphoma, NOS + - Marginal zone lymphoma, NOS + - Masculinovoblastoma + - Mast cell leukaemia + - Mast cell sarcoma + - Mast cell tumor, NOS + - Mastocytoma, NOS + - Matrical carcinoma + - Mature T ALL + - Mature T-cell lymphoma, NOS + - Mature teratoma + - Mediastinal (thymic) large B-cell lymphoma + - Mediterranean lymphoma + - Medullary adenocarcinoma + - Medullary carcinoma with amyloid stroma + - Medullary carcinoma with lymphoid stroma + - Medullary carcinoma, NOS + - Medullary osteosarcoma + - Medulloblastoma with extensive nodularity + - Medulloblastoma, classic + - Medulloblastoma, group 3 + - Medulloblastoma, group 4 + - Medulloblastoma, non-WNT/non-SHH + - Medulloblastoma, NOS + - Medulloblastoma, SHH-activated and TP53-mutant + - Medulloblastoma, SHH-activated and TP53-wildtype + - Medulloblastoma, WNT-activated + - Medullocytoma + - Medulloepithelioma, benign + - Medulloepithelioma, NOS + - Medullomyoblastoma + - Megakaryocytic leukemia + - Megakaryocytic myelosclerosis + - Melanoameloblastoma + - Melanocytic nevus + - Melanocytoma, eyeball + - Melanocytoma, NOS + - Melanoma in situ + - Melanoma, malignant, of soft parts + - Melanoma, NOS + - Melanotic medulloblastoma + - Melanotic MPNST + - Melanotic neuroectodermal tumor + - Melanotic neurofibroma + - Melanotic progonoma + - Melanotic psammomatous MPNST + - Melanotic schwannoma + - Meningeal melanocytoma + - Meningeal melanoma + - Meningeal melanomatosis + - Meningeal sarcoma + - Meningeal sarcomatosis + - Meningioma, anaplastic + - Meningioma, malignant + - Meningioma, NOS + - Meningiomatosis, NOS + - Meningothelial meningioma + - Meningothelial sarcoma + - Merkel cell carcinoma + - Merkel cell tumor + - Mesenchymal chondrosarcoma + - Mesenchymal tumor, malignant + - Mesenchymoma, benign + - Mesenchymoma, malignant + - Mesenchymoma, NOS + - Mesenteric fibromatosis + - Mesoblastic nephroma + - Mesodermal mixed tumor + - Mesonephric adenocarcinoma + - Mesonephric adenoma + - Mesonephric tumor, NOS + - Mesonephroma, benign + - Mesonephroma, malignant + - Mesonephroma, NOS + - Mesothelial papilloma + - Mesothelioma, benign + - Mesothelioma, biphasic, malignant + - Mesothelioma, biphasic, NOS + - Mesothelioma, malignant + - Mesothelioma, NOS + - Metanephric adenoma + - Metaplastic carcinoma of no special type + - Metaplastic carcinoma with chondroid differentiation + - Metaplastic carcinoma with osseous differentiation + - Metaplastic carcinoma with other types mesenchymal differentiation + - Metaplastic carcinoma, NOS + - Metaplastic meningioma + - Metastasizing leiomyoma + - Metastatic signet ring cell carcinoma + - Metatypical carcinoma + - MGUS + - Microcystic adenoma + - Microcystic adnexal carcinoma + - Microcystic meningioma + - Microcystic urothelial carcinoma + - Microfollicular adenoma, NOS + - Microglioma + - Micropapillary adenocarcinoma + - Micropapillary carcinoma, NOS + - Micropapillary serous carcinoma + - Midline carcinoma of children and young adults with NUT rearrangement + - Minimally invasive adenocarcinoma, mucinous + - Minimally invasive adenocarcinoma, non-mucinous + - Minimally invasive adenocarcinoma, NOS + - MiT family translocation renal cell carcinoma + - Mixed acidophil-basophil adenoma + - Mixed acidophil-basophil carcinoma + - Mixed acinar-ductal carcinoma + - Mixed acinar-endocrine carcinoma + - Mixed acinar-endocrine-ductal carcinoma + - Mixed adenocarcinoma and epidermoid carcinoma + - Mixed adenocarcinoma and squamous cell carcinoma + - Mixed adenomatous and hyperplastic polyp + - Mixed adenoneuroendocrine carcinoma + - Mixed basal-squamous cell carcinoma + - Mixed carcinoid-adenocarcinoma + - Mixed cell adenocarcinoma + - Mixed cell adenoma + - Mixed ductal-endocrine carcinoma + - Mixed embryonal carcinoma and teratoma + - Mixed embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma + - Mixed endocrine and exocrine adenocarcinoma + - Mixed epithelioid and spindle cell melanoma + - Mixed germ cell sex cord-stromal tumor, unclassified + - Mixed germ cell tumor + - Mixed glioma + - Mixed hepatocellular and bile duct carcinoma + - Mixed invasive mucinous and non-mucinous adenocarcinoma + - Mixed islet cell and exocrine adenocarcinoma + - Mixed liposarcoma + - Mixed medullary-follicular carcinoma + - Mixed medullary-papillary carcinoma + - Mixed meningioma + - Mixed mesenchymal sarcoma + - Mixed mesenchymal tumor + - Mixed pancreatic endocrine and exocrine tumor, malignant + - Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1 + - Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged + - Mixed phenotype acute leukemia, B/myeloid, NOS + - Mixed phenotype acute leukemia, T/myeloid, NOS + - Mixed pineal tumor + - Mixed pineocytoma-pineoblastoma + - Mixed small cell carcinoma + - Mixed squamous cell and glandular papilloma + - Mixed subependymoma-ependymoma + - Mixed teratoma and seminoma + - Mixed tumor, malignant, NOS + - Mixed tumor, NOS + - Mixed tumor, salivary gland type, malignant + - Mixed tumor, salivary gland type, NOS + - Mixed type rhabdomyosarcoma + - Monoblastic leukemia, NOS + - Monoclonal gammopathy of undetermined significance + - Monoclonal gammopathy, NOS + - Monocytic leukemia, NOS + - Monocytoid B-cell lymphoma + - Monomorphic adenoma + - Monstrocellular sarcoma + - MPNST with glandular differentiation + - MPNST with mesenchymal differentiation + - MPNST with rhabdomyoblastic differentiation + - MPNST, NOS + - Mu heavy chain disease + - Mucin-producing adenocarcinoma + - Mucin-producing carcinoma + - Mucin-secreting adenocarcinoma + - Mucin-secreting carcinoma + - Mucinous adenocarcinofibroma + - Mucinous adenocarcinoma + - Mucinous adenocarcinoma, endocervical type + - Mucinous adenofibroma of borderline malignancy + - Mucinous adenofibroma, NOS + - Mucinous adenoma + - Mucinous carcinoid + - Mucinous carcinoma + - Mucinous carcinoma, gastric type + - Mucinous carcinoma, intestinal type + - Mucinous cystadenocarcinofibroma + - Mucinous cystadenocarcinoma, non-invasive + - Mucinous cystadenocarcinoma, NOS + - Mucinous cystadenofibroma of borderline malignancy + - Mucinous cystadenofibroma, NOS + - Mucinous cystadenoma, borderline malignancy + - Mucinous cystadenoma, NOS + - Mucinous cystic neoplasm with an associated invasive carcinoma + - Mucinous cystic neoplasm with high-grade dysplasia + - Mucinous cystic neoplasm with high-grade intraepithelial neoplasia + - Mucinous cystic neoplasm with intermediate-grade dysplasia + - Mucinous cystic neoplasm with intermediate-grade intraepithelial neoplasia + - Mucinous cystic neoplasm with low-grade dysplasia + - Mucinous cystic neoplasm with low-grade intraepithelial neoplasia + - Mucinous cystic tumor of borderline malignancy + - Mucinous cystic tumor with an associated invasive carcinoma + - Mucinous cystic tumor with high-grade dysplasia + - Mucinous cystic tumor with intermediate dysplasia + - Mucinous cystic tumor with low grade dysplasia + - Mucinous cystic tumor with moderate dysplasia + - Mucinous cystoma + - Mucinous tubular and spindle cell carcinoma + - Mucinous tumor, NOS, of low malignant potential + - Mucocarcinoid tumor + - Mucoepidermoid carcinoma + - Mucoepidermoid tumor + - Mucoid adenocarcinoma + - Mucoid carcinoma + - Mucoid cell adenocarcinoma + - Mucoid cell adenoma + - Mucosal lentiginous melanoma + - Mucosal-associated lymphoid tissue lymphoma + - Mucous adenocarcinoma + - Mucous carcinoma + - Mullerian adenosarcoma + - Mullerian mixed tumor + - Multicentric basal cell carcinoma + - Multicystic mesothelioma, benign + - Multifocal superficial basal cell carcinoma + - Multiple adenomatous polyps + - Multiple endocrine adenomas + - Multiple hemorrhagic sarcoma + - Multiple meningiomas + - Multiple myeloma + - Multiple neurofibromatosis + - Mycosis fungoides + - Myelocytic leukemia, NOS + - Myelodysplastic syndrome with 5q deletion (5q-) syndrome + - Myelodysplastic syndrome with isolated del (5q) + - Myelodysplastic syndrome, NOS + - Myelodysplastic syndrome, unclassifiable + - Myelodysplastic/myeloproliferative neoplasm, unclassifiable + - Myelofibrosis as a result of myeloproliferative disease + - Myelofibrosis with myeloid metaplasia + - Myelogenous leukemia, NOS + - Myeloid and lymphoid neoplasms with FGFR1 abnormalities + - Myeloid and lymphoid neoplasms with PDGFRA rearrangement + - Myeloid leukemia associated with Down Syndrome + - Myeloid leukemia, NOS + - Myeloid neoplasms with PDGFRB rearrangement + - Myeloid sarcoma + - Myelolipoma + - Myeloma, NOS + - Myelomatosis + - Myelomonocytic leukemia, NOS + - Myeloproliferative disease, NOS + - Myeloproliferative neoplasm, NOS + - Myelosclerosis with myeloid metaplasia + - Myloproliferative neoplasm, unclassifiable + - Myoepithelial adenoma + - Myoepithelial carcinoma + - Myoepithelial tumor + - Myoepithelioma + - Myofibroblastic sarcoma + - Myofibroblastic tumor, NOS + - Myofibroblastic tumor, peribronchial + - Myofibroblastoma + - Myofibroma + - Myofibromatosis + - Myoma + - Myosarcoma + - Myxofibroma, NOS + - Myxofibrosarcoma + - Myxoid chondrosarcoma + - Myxoid fibroma + - Myxoid leiomyosarcoma + - Myxoid liposarcoma + - Myxoinflammatory fibroblastic sarcoma (MIFS) + - Myxolipoma + - Myxoliposarcoma + - Myxoma, NOS + - Myxopapillary ependymoma + - Myxosarcoma + - Neoplasm, benign + - Neoplasm, malignant + - Neoplasm, malignant, uncertain whether primary or metastatic + - Neoplasm, metastatic + - Neoplasm, NOS + - Neoplasm, secondary + - Neoplasm, uncertain whether benign or malignant + - Nephroblastoma, NOS + - Nephrogenic adenofibroma + - Nephroma, NOS + - Nerve sheath myxoma + - Nesidioblastoma + - Nested urothelial carcinoma + - Neurilemoma, malignant + - Neurilemoma, NOS + - Neurilemosarcoma + - Neurinoma + - Neurinomatosis + - Neuroastrocytoma + - Neuroblastoma, NOS + - Neurocytoma + - Neuroectodermal tumor, NOS + - Neuroendocrine carcinoma, low grade + - Neuroendocrine carcinoma, moderately differentiated + - Neuroendocrine carcinoma, NOS + - Neuroendocrine carcinoma, poorly differentiated + - Neuroendocrine carcinoma, well-differentiated + - Neuroendocrine tumor, grade 1 + - Neuroendocrine tumor, grade 2 + - Neuroendocrine tumor, well differentiated + - Neuroepithelioma, NOS + - Neurofibroma, NOS + - Neurofibromatosis, NOS + - Neurofibrosarcoma + - Neurogenic sarcoma + - Neurolipocytoma + - Neuroma, NOS + - Neuronevus + - Neurosarcoma + - Neurothekeoma + - Neurotropic melanoma, malignant + - Nevus, NOS + - NK-cell large granular lymphocytic leukemia + - NK/T-cell lymphoma, nasal and nasal-type + - Nodal marginal zone lymphoma + - Nodular hidradenoma + - Nodular hidradenoma, malignant + - Nodular melanoma + - Non-Hodgkin lymphoma, NOS + - Non-invasive EFVPTC + - Non-invasive encapsulated follicular variant of papillary thyroid carcinoma + (non-invasive EFVPTC) + - Non-invasive follicular thyroid neoplasm with papillary-like nuclear features + (NIFTP) + - Non-invasive FTP + - Non-invasive low grade serous carcinoma + - Non-invasive mammary carcinoma + - Non-lymphocytic leukemia, NOS + - Non-small cell carcinoma + - Nonchromaffin paraganglioma, malignant + - Nonchromaffin paraganglioma, NOS + - Nonencapsulated sclerosing adenocarcinoma + - Nonencapsulated sclerosing carcinoma + - Nonencapsulated sclerosing tumor + - Noninfiltrating intracystic carcinoma + - Noninfiltrating intraductal papillary adenocarcinoma + - Noninfiltrating intraductal papillary carcinoma + - Noninvasive pancreatobiliary papillary neoplasm with high grade dysplasia + - Noninvasive pancreatobiliary papillary neoplasm with high grade intraepithelial + neoplasia + - Noninvasive pancreatobiliary papillary neoplasm with low grade dysplasia + - Noninvasive pancreatobiliary papillary neoplasm with low grade intraepithelial + neoplasia + - Nonlipid reticuloendotheliosis + - Nonpigmented nevus + - NUT carcinoma + - NUT midline carcinoma + - Oat cell carcinoma + - Odontoameloblastoma + - Odontogenic carcinoma + - Odontogenic carcinosarcoma + - Odontogenic fibroma, NOS + - Odontogenic fibrosarcoma + - Odontogenic ghost cell tumor + - Odontogenic myxofibroma + - Odontogenic myxoma + - Odontogenic sarcoma + - Odontogenic tumor, benign + - Odontogenic tumor, malignant + - Odontogenic tumor, NOS + - Odontoma, NOS + - Olfactory neuroblastoma + - Olfactory neurocytoma + - Olfactory neuroepithelioma + - Olfactory neurogenic tumor + - Oligoastrocytoma + - Oligodendroblastoma + - Oligodendroglioma, anaplastic + - Oligodendroglioma, IDH-mutant and 1p/19q-codeleted + - Oligodendroglioma, NOS + - Oncocytic adenocarcinoma + - Oncocytic adenoma + - Oncocytic carcinoma + - Oncocytic Schneiderian papilloma + - Oncocytoma + - Orchioblastoma + - Ossifying fibroma + - Ossifying fibromyxoid tumor + - Ossifying fibromyxoid tumor, malignant + - Ossifying renal tumor + - Osteoblastic sarcoma + - Osteoblastoma, malignant + - Osteoblastoma, NOS + - Osteocartilaginous exostosis + - Osteochondroma + - Osteochondromatosis, NOS + - Osteochondrosarcoma + - Osteofibroma + - Osteofibrosarcoma + - Osteogenic sarcoma, NOS + - Osteoid osteoma, NOS + - Osteoma, NOS + - Osteosarcoma in Paget disease of bone + - Osteosarcoma, NOS + - Ovarian stromal tumor + - Oxyphilic adenocarcinoma + - Oxyphilic adenoma + - Pacinian tumor + - Paget disease and infiltrating duct carcinoma of breast + - Paget disease and intraductal carcinoma of breast + - Paget disease of breast + - Paget disease, extramammary + - Paget disease, mammary + - Pagetoid reticulosis + - Pancreatic endocrine tumor, benign + - Pancreatic endocrine tumor, malignant + - Pancreatic endocrine tumor, nonfunctioning + - Pancreatic endocrine tumor, NOS + - Pancreatic microadenoma + - Pancreatic peptide and pancreatic peptide-like peptide within terminal tyrosine + amide producing tumor + - Pancreatobiliary neoplasm, non-invasive + - Pancreatobiliary-type carcinoma + - Pancreatoblastoma + - Papillary adenocarcinoma, follicular variant + - Papillary adenocarcinoma, NOS + - Papillary adenofibroma + - Papillary adenoma, NOS + - Papillary and follicular adenocarcinoma + - Papillary and follicular carcinoma + - Papillary carcinoma in situ + - Papillary carcinoma of thyroid + - Papillary carcinoma, columnar cell + - Papillary carcinoma, diffuse sclerosing + - Papillary carcinoma, encapsulated + - Papillary carcinoma, follicular variant + - Papillary carcinoma, NOS + - Papillary carcinoma, oxyphilic cell + - Papillary carcinoma, tall cell + - Papillary cystadenocarcinoma, NOS + - Papillary cystadenoma lymphomatosum + - Papillary cystadenoma, borderline malignancy + - Papillary cystadenoma, NOS + - Papillary cystic tumor + - Papillary ependymoma + - Papillary epidermoid carcinoma + - Papillary glioneuronal tumor + - Papillary hidradenoma + - Papillary meningioma + - Papillary microcarcinoma + - Papillary mucinous cystadenocarcinoma + - Papillary mucinous cystadenoma, borderline malignancy + - Papillary mucinous cystadenoma, NOS + - Papillary mucinous tumor of low malignant potential + - Papillary neoplasm, pancreatobiliary-type, with high grade intraepithelial + neoplasia + - Papillary pseudomucinous cystadenocarcinoma + - Papillary pseudomucinous cystadenoma, borderline malignancy + - Papillary pseudomucinous cystadenoma, NOS + - Papillary renal cell carcinoma + - Papillary serous adenocarcinoma + - Papillary serous cystadenocarcinoma + - Papillary serous cystadenoma, borderline malignancy + - Papillary serous cystadenoma, NOS + - Papillary serous tumor of low malignant potential + - Papillary squamous cell carcinoma + - Papillary squamous cell carcinoma in situ + - Papillary squamous cell carcinoma, non-invasive + - Papillary syringadenoma + - Papillary syringocystadenoma + - Papillary transitional cell carcinoma + - Papillary transitional cell carcinoma, non-invasive + - Papillary transitional cell neoplasm of low malignant potential + - Papillary tumor of the pineal region + - Papillary urothelial carcinoma + - Papillary urothelial carcinoma, non-invasive + - Papillary urothelial neoplasm of low malignant potential + - Papillocystic adenocarcinoma + - Papilloma of bladder + - Papilloma, NOS + - Papillomatosis, glandular + - Papillomatosis, NOS + - Papillotubular adenocarcinoma + - Papillotubular adenoma + - Parachordoma + - Parafollicular cell carcinoma + - Paraganglioma, benign + - Paraganglioma, malignant + - Paraganglioma, NOS + - Parasympathetic paraganglioma + - Parietal cell adenocarcinoma + - Parietal cell carcinoma + - Parosteal osteosarcoma + - Partial hydatidiform mole + - PEComa, malignant + - Periapical cemental dysplasia + - Periapical cemento-osseous dysplasia + - Pericanalicular fibroadenoma + - Periductal stromal tumor, low grade + - Perifollicular fibroma + - Perineural MPNST + - Perineurioma, malignant + - Perineurioma, NOS + - Periosteal chondroma + - Periosteal chondrosarcoma + - Periosteal fibroma + - Periosteal fibrosarcoma + - Periosteal osteosarcoma + - Periosteal sarcoma, NOS + - Peripheral neuroectodermal tumor + - Peripheral odontogenic fibroma + - Peripheral primitive neuroectodermal tumor, NOS + - Peripheral T-cell lymphoma, AILD (Angioimmunoblastic Lymphadenopathy with + Dysproteinemia) + - Peripheral T-cell lymphoma, large cell + - Peripheral T-cell lymphoma, NOS + - Peripheral T-cell lymphoma, pleomorphic medium and large cell + - Peripheral T-cell lymphoma, pleomorphic small cell + - Perivascular epithelioid cell tumor, malignant + - Pheochromoblastoma + - Pheochromocytoma, malignant + - Pheochromocytoma, NOS + - Phosphaturic mesenchymal tumor, malignant + - Phyllodes tumor, benign + - Phyllodes tumor, borderline + - Phyllodes tumor, malignant + - Phyllodes tumor, NOS + - Pick tubular adenoma + - Pigmented adenoma + - Pigmented basal cell carcinoma + - Pigmented dermatofibrosarcoma protuberans + - Pigmented nevus, NOS + - Pigmented schwannoma + - Pigmented spindle cell nevus of Reed + - Pilar tumor + - Pilocytic astrocytoma + - Piloid astrocytoma + - Pilomatricoma, malignant + - Pilomatricoma, NOS + - Pilomatrix carcinoma + - Pilomatrixoma, malignant + - Pilomatrixoma, NOS + - Pilomyxoid astrocytoma + - PIN III + - Pindborg tumor + - Pineal parenchymal tumor of intermediate differentiation + - Pinealoma + - Pineoblastoma + - Pineocytoma + - Pinkus tumor + - Pituicytoma + - Pituitary adenoma, NOS + - Pituitary carcinoma, NOS + - Placental site trophoblastic tumor + - Plasma cell leukemia + - Plasma cell myeloma + - Plasma cell tumor + - Plasmablastic lymphoma + - Plasmacytic leukemia + - Plasmacytic lymphoma + - Plasmacytoma of bone + - Plasmacytoma, extramedullary + - Plasmacytoma, NOS + - Pleomorphic adenoma + - Pleomorphic carcinoma + - Pleomorphic cell sarcoma + - Pleomorphic leiomyoma + - Pleomorphic lipoma + - Pleomorphic liposarcoma + - Pleomorphic lobular carcinoma + - Pleomorphic lobular carcinoma in situ + - Pleomorphic rhabdomyosarcoma, adult type + - Pleomorphic rhabdomyosarcoma, NOS + - Pleomorphic xanthoastrocytoma + - Pleuropulmonary blastoma + - Plexiform fibrohistiocytic tumor + - Plexiform fibromyxoma + - Plexiform hemangioma + - Plexiform leiomyoma + - Plexiform neurofibroma + - Plexiform neuroma + - Plexiform schwannoma + - PNET, NOS + - Pneumoblastoma + - Polar spongioblastoma + - Polycythemia rubra vera + - Polycythemia vera + - Polyembryoma + - Polygonal cell carcinoma + - Polymorphic post transplant lymphoproliferative disorder + - Polymorphic reticulosis + - Polymorphous low grade adenocarcinoma + - Polypoid adenoma + - Polyvesicular vitelline tumor + - Poorly cohesive carcinoma + - Porocarcinoma + - Post transplant lymphoproliferative disorder, NOS + - PP/PYY producing tumor + - PPNET + - Pre-B ALL + - Pre-pre-B ALL + - Pre-T ALL + - Precancerous melanosis, NOS + - Precursor B-cell lymphoblastic leukemia + - Precursor B-cell lymphoblastic lymphoma + - Precursor cell lymphoblastic leukemia, NOS + - Precursor cell lymphoblastic leukemia, not phenotyped + - Precursor cell lymphoblastic lymphoma, NOS + - Precursor T-cell lymphoblastic leukemia + - Precursor T-cell lymphoblastic lymphoma + - Preleukemia + - Preleukemic syndrome + - Primary amyloidosis + - Primary cutaneous anaplastic large cell lymphoma + - Primary cutaneous CD4-positive small/medium T-cell lymphoma + - Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell + lymphoma + - Primary cutaneous CD30+ large T-cell lymphoma + - Primary cutaneous CD30+ T-cell lymphoproliferative disorder + - Primary cutaneous DLBCL, leg type + - Primary cutaneous follicle centre lymphoma + - Primary cutaneous gamma-delta T-cell lymphoma + - Primary cutaneous neuroendocrine carcinoma + - Primary diffuse large B-cell lymphoma of the CNS + - Primary effusion lymphoma + - Primary intraosseous carcinoma + - Primary myelofibrosis + - Primary serous papillary carcinoma of peritoneum + - Primitive neuroectodermal tumor, NOS + - Primitive polar spongioblastoma + - Pro-B ALL + - Pro-T ALL + - Prolactinoma + - Proliferating trichilemmal cyst + - Proliferating trichilemmal tumor + - Proliferative dermal lesion in congenital nevus + - Proliferative polycythemia + - Prolymphocytic leukemia, B-cell type + - Prolymphocytic leukemia, NOS + - Prolymphocytic leukemia, T-cell type + - Prostatic intraepithelial neoplasia, grade III + - Protoplasmic astrocytoma + - Psammomatous meningioma + - Psammomatous schwannoma + - Pseudomucinous adenocarcinoma + - Pseudomucinous cystadenocarcinoma, NOS + - Pseudomucinous cystadenoma, borderline malignancy + - Pseudomucinous cystadenoma, NOS + - Pseudomyxoma peritonei + - Pseudomyxoma peritonei with unknown primary site + - Pseudosarcomatous carcinoma + - PTLD, NOS + - Pulmonary adenomatosis + - Pulmonary artery intimal sarcoma + - Pulmonary blastoma + - Pulmonary myxoid sarcoma with EWSR1-CREB1 translocation + - Queyrat erythroplasia + - Racemose hemangioma + - RAEB + - RAEB I + - RAEB II + - RAEB-T + - RARS + - Rathke pouch tumor + - Recklinghausen disease + - Refractory anemia + - Refractory anemia with excess blasts + - Refractory anemia with excess blasts in transformation + - Refractory anemia with ring sideroblasts associated with marked thrombocytosis + - Refractory anemia with ringed sideroblasts + - Refractory anemia with sideroblasts + - Refractory anemia without sideroblasts + - Refractory cytopenia of childhood + - Refractory cytopenia with multilineage dysplasia + - Refractory neutropenia + - Refractory thrombocytopenia + - Regressing nevus + - Renal carcinoma, collecting duct type + - Renal cell adenocarcinoma + - Renal cell carcinoma, chromophobe type + - Renal cell carcinoma, NOS + - Renal cell carcinoma, sarcomatoid + - Renal cell carcinoma, spindle cell + - Renal cell carcinoma, unclassified + - Renal medullary carcinoma + - Reninoma + - Renomedullary fibroma + - Renomedullary interstitial cell tumor + - Reserve cell carcinoma + - Reticulohistiocytoma + - Reticulosarcoma, diffuse + - Reticulosarcoma, NOS + - Reticulum cell sarcoma, diffuse + - Reticulum cell sarcoma, NOS + - Retinal anlage tumor + - Retinoblastoma, differentiated + - Retinoblastoma, diffuse + - Retinoblastoma, NOS + - Retinoblastoma, spontaneously regressed + - Retinoblastoma, undifferentiated + - Retinocytoma + - Retroperitoneal fibromatosis + - Rhabdoid meningioma + - Rhabdoid sarcoma + - Rhabdoid tumor, NOS + - Rhabdomyoma, NOS + - Rhabdomyosarcoma with ganglionic differentiation + - Rhabdomyosarcoma, NOS + - Rhabdosarcoma + - Rodent ulcer + - Rosette-forming glioneuronal tumor + - Round cell carcinoma + - Round cell liposarcoma + - Round cell osteosarcoma + - Round cell sarcoma + - Salivary duct carcinoma + - SALT lymphoma + - Sarcoma botryoides + - Sarcoma, NOS + - Sarcomatoid carcinoma + - Sarcomatoid mesothelioma + - Sarcomatosis, NOS + - Schmincke tumor + - Schneiderian carcinoma + - Schneiderian papilloma, inverted + - Schneiderian papilloma, NOS + - Schwannoma, NOS + - Scirrhous adenocarcinoma + - Scirrhous carcinoma + - Sclerosing epithelioid fibrosarcoma + - Sclerosing hemangioma + - Sclerosing hepatic carcinoma + - Sclerosing liposarcoma + - Sclerosing rhabdomyosarcoma + - Sclerosing stromal tumor + - Sclerosing sweat duct carcinoma + - Sebaceous adenocarcinoma + - Sebaceous adenoma + - Sebaceous carcinoma + - Sebaceous epithelioma + - Secondary carcinoma + - Secretory carcinoma of breast + - Secretory meningioma + - Seminoma with high mitotic index + - Seminoma, anaplastic + - Seminoma, NOS + - Seromucinous carcinoma + - Serotonin producing carcinoid + - Serous adenocarcinofibroma + - Serous adenocarcinoma, NOS + - Serous adenofibroma of borderline malignancy + - Serous adenofibroma, NOS + - Serous borderline tumor-micropapillary variant + - Serous carcinoma, NOS + - Serous cystadenocarcinofibroma + - Serous cystadenocarcinoma, NOS + - Serous cystadenofibroma of borderline malignancy + - Serous cystadenofibroma, NOS + - Serous cystadenoma, borderline malignancy + - Serous cystadenoma, NOS + - Serous cystoma + - Serous endometrial intraepithelial carcinoma + - Serous microcystic adenoma + - Serous papillary cystic tumor of borderline malignancy + - Serous surface papillary carcinoma + - Serous surface papillary tumor of borderline malignancy + - Serous surface papilloma + - Serous tubal intraepithelial carcinoma + - Serous tumor, NOS, of low malignant potential + - Serrated adenocarcinoma + - Serrated adenoma + - Sertoli cell adenoma + - Sertoli cell carcinoma + - Sertoli cell tumor with lipid storage + - Sertoli cell tumor, NOS + - Sertoli-Leydig cell tumor of intermediate differentiation + - Sertoli-Leydig cell tumor, intermediate differentiation, with heterologous + elements + - Sertoli-Leydig cell tumor, NOS + - Sertoli-Leydig cell tumor, poorly differentiated + - Sertoli-Leydig cell tumor, poorly differentiated, with heterologous elements + - Sertoli-Leydig cell tumor, retiform + - Sertoli-Leydig cell tumor, retiform, with heterologous elements + - Sertoli-Leydig cell tumor, sarcomatoid + - Sertoli-Leydig cell tumor, well differentiated + - Sessile serrated adenoma + - Sessile serrated polyp + - SETTLE + - Sex cord tumor with annular tubules + - Sex cord tumor, NOS + - Sex cord-gonadal stromal tumor, incompletely differentiated + - Sex cord-gonadal stromal tumor, mixed forms + - Sex cord-gonadal stromal tumor, NOS + - Sezary disease + - Sezary syndrome + - Sialoblastoma + - Signet ring cell adenocarcinoma + - Signet ring cell carcinoma + - Sinonasal papilloma, exophytic + - Sinonasal papilloma, fungiform + - Sinonasal papilloma, NOS + - Skin appendage adenoma + - Skin appendage carcinoma + - Skin appendage tumor, benign + - Skin-associated lymphoid tissue lymphoma + - Small cell carcinoma pulmonary type + - Small cell carcinoma, fusiform cell + - Small cell carcinoma, hypercalcemic type + - Small cell carcinoma, intermediate cell + - Small cell carcinoma, NOS + - Small cell neuroendocrine carcinoma + - Small cell osteosarcoma + - Small cell sarcoma + - Small congenital nevus + - Smooth muscle tumor of uncertain malignant potential + - Smooth muscle tumor, NOS + - Soft tissue perineurioma + - Soft tissue sarcoma + - Soft tissue tumor, benign + - Soft tissue tumor, malignant + - Solid adenocarcinoma with mucin formation + - Solid and cystic tumor + - Solid and papillary epithelial neoplasm + - Solid carcinoma with mucin formation + - Solid carcinoma, NOS + - Solid papillary carcinoma in situ + - Solid papillary carcinoma with invasion + - Solid pseudopapillary carcinoma + - Solid pseudopapillary tumor + - Solid teratoma + - Solitary fibrous tumor + - Solitary fibrous tumor, malignant + - Solitary fibrous tumor/hemangiopericytoma Grade 1 (CNS) + - Solitary fibrous tumor/hemangiopericytoma Grade 2 (CNS) + - Solitary fibrous tumor/hemangiopericytoma Grade 3 (CNS) + - Solitary mastocytoma of skin + - Solitary myeloma + - Solitary plasmacytoma + - Somatostatin cell tumor, malignant + - Somatostatin cell tumor, NOS + - Somatostatinoma, malignant + - Somatostatinoma, NOS + - Spermatocytic seminoma + - Spermatocytoma + - Spindle cell angioendothelioma + - Spindle cell carcinoma, NOS + - Spindle cell hemangioendothelioma + - Spindle cell lipoma + - Spindle cell melanoma, NOS + - Spindle cell melanoma, type A + - Spindle cell melanoma, type B + - Spindle cell nevus, NOS + - Spindle cell oncocytoma + - Spindle cell rhabdomyosarcoma + - Spindle cell sarcoma + - Spindle epithelial tumor with thymus-like differentiation + - Spindle epithelial tumor with thymus-like element + - Spindled mesothelioma + - Spiradenoma, NOS + - Spitz nevus + - Splenic B-cell lymphoma/leukemia, unclassifiable + - Splenic diffuse red pulp small B-cell lymphoma + - Splenic lymphoma with villous lymphocytes + - Splenic marginal zone B-cell lymphoma + - Splenic marginal zone lymphoma, NOS + - Spongioblastoma multiforme + - Spongioblastoma polare + - Spongioblastoma, NOS + - Spongioneuroblastoma + - Squamotransitional cell carcinoma + - Squamous carcinoma + - Squamous cell carcinoma in situ with questionable stromal invasion + - Squamous cell carcinoma in situ, NOS + - Squamous cell carcinoma with horn formation + - Squamous cell carcinoma, acantholytic + - Squamous cell carcinoma, adenoid + - Squamous cell carcinoma, clear cell type + - Squamous cell carcinoma, HPV-negative + - Squamous cell carcinoma, HPV-positive + - Squamous cell carcinoma, keratinizing, NOS + - Squamous cell carcinoma, large cell, keratinizing + - Squamous cell carcinoma, large cell, nonkeratinizing, NOS + - Squamous cell carcinoma, metastatic, NOS + - Squamous cell carcinoma, microinvasive + - Squamous cell carcinoma, nonkeratinizing, NOS + - Squamous cell carcinoma, NOS + - Squamous cell carcinoma, pseudoglandular + - Squamous cell carcinoma, sarcomatoid + - Squamous cell carcinoma, small cell, nonkeratinizing + - Squamous cell carcinoma, spindle cell + - Squamous cell epithelioma + - Squamous cell papilloma, inverted + - Squamous cell papilloma, NOS + - Squamous intraepithelial neoplasia, grade I + - Squamous intraepithelial neoplasia, grade II + - Squamous intraepithelial neoplasia, grade III + - Squamous intraepithelial neoplasia, high grade + - Squamous intraepithelial neoplasia, low grade + - Squamous odontogenic tumor + - Squamous papilloma + - Squamous papillomatosis + - Stem cell leukemia + - Steroid cell tumor, malignant + - Steroid cell tumor, NOS + - Stromal endometriosis + - Stromal myosis, NOS + - Stromal sarcoma, NOS + - Stromal tumor with minor sex cord elements + - Stromal tumor, benign + - Stromal tumor, NOS + - Struma ovarii and carcinoid + - Struma ovarii, malignant + - Struma ovarii, NOS + - Strumal carcinoid + - Subacute granulocytic leukemia + - Subacute leukemia, NOS + - Subacute lymphatic leukemia + - Subacute lymphocytic leukemia + - Subacute lymphoid leukemia + - Subacute monocytic leukemia + - Subacute myelogenous leukemia + - Subacute myeloid leukemia + - Subareolar duct papillomatosis + - Subcutaneous panniculitis-like T-cell lymphoma + - Subependymal astrocytoma, NOS + - Subependymal giant cell astrocytoma + - Subependymal glioma + - Subependymoma + - Subepidermal nodular fibrosis + - Superficial spreading adenocarcinoma + - Superficial spreading melanoma + - Superficial well differentiated liposarcoma + - Supratentorial PNET + - Sweat gland adenocarcinoma + - Sweat gland adenoma + - Sweat gland carcinoma + - Sweat gland tumor, benign + - Sweat gland tumor, malignant + - Sweat gland tumor, NOS + - Sympathetic paraganglioma + - Sympathicoblastoma + - Symplastic leiomyoma + - Syncytial meningioma + - Synovial sarcoma, biphasic + - Synovial sarcoma, epithelioid cell + - Synovial sarcoma, monophasic fibrous + - Synovial sarcoma, NOS + - Synovial sarcoma, spindle cell + - Synovioma, benign + - Synovioma, malignant + - Synovioma, NOS + - Syringadenoma, NOS + - Syringocystadenoma papilliferum + - Syringofibroadenoma + - Syringoma, NOS + - Syringomatous carcinoma + - Systemic EBV positive T-cell lymphoproliferative disease of childhood + - Systemic light chain disease + - Systemic mastocytosis with AHNMD + - Systemic mastocytosis with associated hematological clonal non-mast cell disorder + - Systemic tissue mast cell disease + - T lymphoblastic leukemia/lymphoma + - T-cell large granular lymphocytic leukemia + - T-cell large granular lymphocytosis + - T-cell lymphoma, NOS + - T-cell rich large B-cell lymphoma + - T-cell rich/histiocyte-rich large B-cell lymphoma + - T-gamma lymphoproliferative disease + - T-zone lymphoma + - T/NK-cell lymphoma + - Tanycytic ependymoma + - Telangiectatic osteosarcoma + - Tenosynovial giant cell tumor + - Teratoblastoma, malignant + - Teratocarcinoma + - Teratoid medulloepithelioma + - Teratoid medulloepithelioma, benign + - Teratoma with malignant transformation + - Teratoma, benign + - Teratoma, differentiated + - Teratoma, malignant, NOS + - Teratoma, NOS + - Terminal duct adenocarcinoma + - Testicular adenoma + - Testicular stromal tumor + - Theca cell tumor + - Theca cell-granulosa cell tumor + - Thecoma, luteinized + - Thecoma, malignant + - Thecoma, NOS + - Therapy related myeloid neoplasm + - Therapy-related acute myeloid leukemia, alkylating agent related + - Therapy-related acute myeloid leukemia, epipodophyllotoxin-related + - Therapy-related acute myeloid leukemia, NOS + - Therapy-related myelodysplastic syndrome, alkylating agent related + - Therapy-related myelodysplastic syndrome, epipodophyllotoxin-related + - Therapy-related myelodysplastic syndrome, NOS + - Thymic carcinoma with adenoid cystic carcinoma-like features + - Thymic carcinoma, NOS + - Thymic large B-cell lymphoma + - Thymoma, atypical, malignant + - Thymoma, atypical, NOS + - Thymoma, benign + - Thymoma, cortical, malignant + - Thymoma, cortical, NOS + - Thymoma, epithelial, malignant + - Thymoma, epithelial, NOS + - Thymoma, lymphocyte-rich, malignant + - Thymoma, lymphocyte-rich, NOS + - Thymoma, lymphocytic, malignant + - Thymoma, lymphocytic, NOS + - Thymoma, malignant, NOS + - Thymoma, medullary, malignant + - Thymoma, medullary, NOS + - Thymoma, mixed type, malignant + - Thymoma, mixed type, NOS + - Thymoma, NOS + - Thymoma, organoid, malignant + - Thymoma, organoid, NOS + - Thymoma, predominantly cortical, malignant + - Thymoma, predominantly cortical, NOS + - Thymoma, spindle cell, malignant + - Thymoma, spindle cell, NOS + - Thymoma, type A, malignant + - Thymoma, type A, NOS + - Thymoma, type AB, malignant + - Thymoma, type AB, NOS + - Thymoma, type B1, malignant + - Thymoma, type B1, NOS + - Thymoma, type B2, malignant + - Thymoma, type B2, NOS + - Thymoma, type B3, malignant + - Thymoma, type B3, NOS + - Thymoma, type C + - Tibial adamantinoma + - Trabecular adenocarcinoma + - Trabecular adenoma + - Trabecular carcinoma + - Traditional serrated adenoma + - Traditional sessile serrated adenoma + - Transient abnormal myelopoiesis + - Transitional carcinoma + - Transitional cell carcinoma + - Transitional cell carcinoma in situ + - Transitional cell carcinoma, micropapillary + - Transitional cell carcinoma, sarcomatoid + - Transitional cell carcinoma, spindle cell + - Transitional cell papilloma, benign + - Transitional cell papilloma, inverted, benign + - Transitional cell papilloma, inverted, NOS + - Transitional cell papilloma, NOS + - Transitional meningioma + - Transitional papilloma + - Transitional papilloma, inverted, benign + - Transitional papilloma, inverted, NOS + - Transitional pineal tumor + - Trichilemmal carcinoma + - Trichilemmocarcinoma + - Trichilemmoma + - Trichodiscoma + - Trichoepithelioma + - Trichofolliculoma + - Triton tumor, malignant + - Trophoblastic tumor, epithelioid + - True histiocytic lymphoma + - Tubular adenocarcinoma + - Tubular adenoma, NOS + - Tubular androblastoma with lipid storage + - Tubular androblastoma, NOS + - Tubular carcinoid + - Tubular carcinoma + - Tubulo-papillary adenoma + - Tubulocystic renal cell carcinoma + - Tubulolobular carcinoma + - Tubulopapillary adenocarcinoma + - Tubulovillous adenoma, NOS + - Tumor cells, benign + - Tumor cells, malignant + - Tumor cells, NOS + - Tumor cells, uncertain whether benign or malignant + - Tumor embolus + - Tumor, benign + - Tumor, malignant, NOS + - Tumor, metastatic + - Tumor, NOS + - Tumor, secondary + - Tumorlet, benign + - Tumorlet, NOS + - Turban tumor + - Typical carcinoid + - Unclassified tumor, benign + - Unclassified tumor, borderline malignancy + - Unclassified tumor, malignant + - Unclassified tumor, malignant, uncertain whether primary or metastatic + - Unclassified tumor, uncertain whether benign or malignant + - Undifferentiated epithelioid sarcoma + - Undifferentiated high-grade pleomorphic sarcoma + - Undifferentiated leukaemia + - Undifferentiated pleomorphic sarcoma + - Undifferentiated round cell sarcoma + - Undifferentiated sarcoma + - Undifferentiated spindle cell sarcoma + - Undifferentiated uterine sarcoma + - Urachal carcinoma + - Urothelial carcinoma in situ + - Urothelial carcinoma with divergent differentiation + - Urothelial carcinoma with squamous differentiation + - Urothelial carcinoma with trophoblastic differentiation + - Urothelial carcinoma, NOS + - Urothelial papilloma, NOS + - Urticaria pigmentosa + - Vaginal intraepithelial neoplasia, grade III + - VAIN III + - Vascular leiomyoma + - Venous hemangioma + - Verrucous carcinoma, NOS + - Verrucous epidermoid carcinoma + - Verrucous keratotic hemangioma + - Verrucous papilloma + - Verrucous squamous cell carcinoma + - Villoglandular adenoma + - Villoglandular carcinoma + - Villous adenocarcinoma + - Villous adenoma, NOS + - Villous papilloma + - VIN III + - Vipoma, malignant + - Vipoma, NOS + - Von Recklinghausen disease + - Vulvar intraepithelial neoplasia, grade III + - Waldenstrom macroglobulinemia + - Warthin tumor + - Warty carcinoma + - Water-clear cell adenocarcinoma + - Water-clear cell adenoma + - Water-clear cell carcinoma + - Well differentiated liposarcoma of superficial soft tissue + - Well differentiated papillary mesothelioma, benign + - Well differentiated thymic carcinoma + - Wilms tumor + - Wolffian duct adenoma + - Wolffian duct carcinoma + - Wolffian duct tumor + - Xanthofibroma + - Yolk sac tumor + - Unknown + - Not Reported + deprecated_enum: + - Adenocarcinoma in tubolovillous adenoma + enumDef: + Abdominal desmoid: + $ref: + - "_terms_enum.yaml#/abdominal_desmoid/common" + Abdominal fibromatosis: + $ref: + - "_terms_enum.yaml#/abdominal_fibromatosis/common" + Achromic nevus: + $ref: + - "_terms_enum.yaml#/achromic_nevus/common" + Acidophil adenocarcinoma: + $ref: + - "_terms_enum.yaml#/acidophil_adenocarcinoma/common" + Acidophil adenoma: + $ref: + - "_terms_enum.yaml#/acidophil_adenoma/common" + Acidophil carcinoma: + $ref: + - "_terms_enum.yaml#/acidophil_carcinoma/common" + Acinar adenocarcinoma: + $ref: + - "_terms_enum.yaml#/acinar_adenocarcinoma/common" + Acinar adenocarcinoma, sarcomatoid: + $ref: + - "_terms_enum.yaml#/acinar_adenocarcinoma_sarcomatoid/common" + Acinar adenoma: + $ref: + - "_terms_enum.yaml#/acinar_adenoma/common" + Acinar carcinoma: + $ref: + - "_terms_enum.yaml#/acinar_carcinoma/common" + Acinar cell adenoma: + $ref: + - "_terms_enum.yaml#/acinar_cell_adenoma/common" + Acinar cell carcinoma: + $ref: + - "_terms_enum.yaml#/acinar_cell_carcinoma/common" + Acinar cell cystadenocarcinoma: + $ref: + - "_terms_enum.yaml#/acinar_cell_cystadenocarcinoma/common" + Acinar cell tumor: + $ref: + - "_terms_enum.yaml#/acinar_cell_tumor/common" + Acinic cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/acinic_cell_adenocarcinoma/common" + Acinic cell adenoma: + $ref: + - "_terms_enum.yaml#/acinic_cell_adenoma/common" + Acinic cell tumor: + $ref: + - "_terms_enum.yaml#/acinic_cell_tumor/common" + Acoustic neuroma: + $ref: + - "_terms_enum.yaml#/acoustic_neuroma/common" + Acquired cystic disease-associated renal cell carcinoma (RCC): + $ref: + - "_terms_enum.yaml#/acquired_cystic_diseaseassociated_renal_cell_carcinoma_rcc/common" + Acral lentiginous melanoma, malignant: + $ref: + - "_terms_enum.yaml#/acral_lentiginous_melanoma_malignant/common" + Acute basophilic leukaemia: + $ref: + - "_terms_enum.yaml#/acute_basophilic_leukaemia/common" + Acute bilineal leukemia: + $ref: + - "_terms_enum.yaml#/acute_bilineal_leukemia/common" + Acute biphenotypic leukemia: + $ref: + - "_terms_enum.yaml#/acute_biphenotypic_leukemia/common" + Acute erythremia: + $ref: + - "_terms_enum.yaml#/acute_erythremia/common" + Acute erythremic myelosis: + $ref: + - "_terms_enum.yaml#/acute_erythremic_myelosis/common" + Acute erythroid leukaemia: + $ref: + - "_terms_enum.yaml#/acute_erythroid_leukaemia/common" + Acute granulocytic leukemia: + $ref: + - "_terms_enum.yaml#/acute_granulocytic_leukemia/common" + Acute leukemia, Burkitt type: + $ref: + - "_terms_enum.yaml#/acute_leukemia_burkitt_type/common" + Acute leukemia, NOS: + $ref: + - "_terms_enum.yaml#/acute_leukemia_nos/common" + Acute lymphatic leukemia: + $ref: + - "_terms_enum.yaml#/acute_lymphatic_leukemia/common" + Acute lymphoblastic leukemia, L2 type, NOS: + $ref: + - "_terms_enum.yaml#/acute_lymphoblastic_leukemia_l2_type_nos/common" + Acute lymphoblastic leukemia, mature B-cell type: + $ref: + - "_terms_enum.yaml#/acute_lymphoblastic_leukemia_mature_bcell_type/common" + Acute lymphoblastic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/acute_lymphoblastic_leukemia_nos/common" + Acute lymphoblastic leukemia, precursor cell type: + $ref: + - "_terms_enum.yaml#/acute_lymphoblastic_leukemia_precursor_cell_type/common" + Acute lymphoblastic leukemia-lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/acute_lymphoblastic_leukemialymphoma_nos/common" + Acute lymphocytic leukemia: + $ref: + - "_terms_enum.yaml#/acute_lymphocytic_leukemia/common" + Acute lymphoid leukemia: + $ref: + - "_terms_enum.yaml#/acute_lymphoid_leukemia/common" + Acute megakaryoblastic leukaemia: + $ref: + - "_terms_enum.yaml#/acute_megakaryoblastic_leukaemia/common" + Acute mixed lineage leukemia: + $ref: + - "_terms_enum.yaml#/acute_mixed_lineage_leukemia/common" + Acute monoblastic and monocytic leukemia: + $ref: + - "_terms_enum.yaml#/acute_monoblastic_and_monocytic_leukemia/common" + Acute monoblastic leukemia: + $ref: + - "_terms_enum.yaml#/acute_monoblastic_leukemia/common" + Acute monocytic leukemia: + $ref: + - "_terms_enum.yaml#/acute_monocytic_leukemia/common" + Acute myeloblastic leukemia: + $ref: + - "_terms_enum.yaml#/acute_myeloblastic_leukemia/common" + Acute myelocytic leukemia: + $ref: + - "_terms_enum.yaml#/acute_myelocytic_leukemia/common" + Acute myelofibrosis: + $ref: + - "_terms_enum.yaml#/acute_myelofibrosis/common" + Acute myelogenous leukemia: + $ref: + - "_terms_enum.yaml#/acute_myelogenous_leukemia/common" + Acute myeloid leukaemia, t(8;21)(q22;q22): + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukaemia_t821q22q22/common" + Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_megakaryoblastic_with_t122p13q13_rbm15mkl1/common" + Acute myeloid leukemia with abnormal marrow eosinophils (includes all variants): + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_abnormal_marrow_eosinophils_includes_all_variants/common" + Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_inv3q21q262_or_t33q21q262_rpn1evi1/common" + Acute myeloid leukemia with maturation: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_maturation/common" + Acute myeloid leukemia with multilineage dysplasia: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_multilineage_dysplasia/common" + Acute myeloid leukemia with mutated CEBPA: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_mutated_cebpa/common" + Acute myeloid leukemia with mutated NPM1: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_mutated_npm1/common" + Acute myeloid leukemia with myelodysplasia-related changes: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_myelodysplasiarelated_changes/common" + Acute myeloid leukemia with prior myelodysplastic syndrome: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_prior_myelodysplastic_syndrome/common" + Acute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_t69p23q34_deknup214/common" + Acute myeloid leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_t821q22q22_runx1runx1t1/common" + Acute myeloid leukemia with t(9;11)(p22;q23); MLLT3-MLL: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_with_t911p22q23_mllt3mll/common" + Acute myeloid leukemia without maturation: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_without_maturation/common" + Acute myeloid leukemia without prior myelodysplastic syndrome: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_without_prior_myelodysplastic_syndrome/common" + Acute myeloid leukemia, AML1(CBF-alpha)/ETO: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_aml1cbfalphaeto/common" + Acute myeloid leukemia, CBF-beta/MYH11: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_cbfbetamyh11/common" + Acute myeloid leukemia, inv(16)(p13;q22): + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_inv16p13q22/common" + Acute myeloid leukemia, M6 type: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_m6_type/common" + Acute myeloid leukemia, minimal differentiation: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_minimal_differentiation/common" + Acute myeloid leukemia, MLL: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_mll/common" + Acute myeloid leukemia, NOS: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_nos/common" + Acute myeloid leukemia, PML/RAR-alpha: + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_pmlraralpha/common" + Acute myeloid leukemia, t(16;16)(p 13;q 11): + $ref: + - "_terms_enum.yaml#/acute_myeloid_leukemia_t1616p_13q_11/common" + Acute myelomonocytic leukemia: + $ref: + - "_terms_enum.yaml#/acute_myelomonocytic_leukemia/common" + Acute myelomonocytic leukemia with abnormal eosinophils: + $ref: + - "_terms_enum.yaml#/acute_myelomonocytic_leukemia_with_abnormal_eosinophils/common" + Acute myelosclerosis, NOS: + $ref: + - "_terms_enum.yaml#/acute_myelosclerosis_nos/common" + Acute myloid leukemia, 11q23 abnormalities: + $ref: + - "_terms_enum.yaml#/acute_myloid_leukemia_11q23_abnormalities/common" + Acute non-lymphocytic leukemia: + $ref: + - "_terms_enum.yaml#/acute_nonlymphocytic_leukemia/common" + Acute panmyelosis with myelofibrosis: + $ref: + - "_terms_enum.yaml#/acute_panmyelosis_with_myelofibrosis/common" + Acute panmyelosis, NOS: + $ref: + - "_terms_enum.yaml#/acute_panmyelosis_nos/common" + Acute promyelocytic leukaemia, PML-RAR-alpha: + $ref: + - "_terms_enum.yaml#/acute_promyelocytic_leukaemia_pmlraralpha/common" + Acute promyelocytic leukaemia, t(15;17)(q22;q11-12): + $ref: + - "_terms_enum.yaml#/acute_promyelocytic_leukaemia_t1517q22q1112/common" + Acute promyelocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/acute_promyelocytic_leukemia_nos/common" + Adamantinoma of long bones: + $ref: + - "_terms_enum.yaml#/adamantinoma_of_long_bones/common" + Adamantinoma, malignant: + $ref: + - "_terms_enum.yaml#/adamantinoma_malignant/common" + Adamantinoma, NOS: + $ref: + - "_terms_enum.yaml#/adamantinoma_nos/common" + Adenoacanthoma: + $ref: + - "_terms_enum.yaml#/adenoacanthoma/common" + Adenoameloblastoma: + $ref: + - "_terms_enum.yaml#/adenoameloblastoma/common" + Adenocarcinoid tumor: + $ref: + - "_terms_enum.yaml#/adenocarcinoid_tumor/common" + Adenocarcinoma admixed with neuroendocrine carcinoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_admixed_with_neuroendocrine_carcinoma/common" + Adenocarcinoma combined with other types of carcinoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_combined_with_other_types_of_carcinoma/common" + Adenocarcinoma in a polyp, NOS: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_a_polyp_nos/common" + Adenocarcinoma in adenomatous polyp: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_adenomatous_polyp/common" + Adenocarcinoma in adenomatous polyposis coli: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_adenomatous_polyposis_coli/common" + Adenocarcinoma in multiple adenomatous polyps: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_multiple_adenomatous_polyps/common" + Adenocarcinoma in polypoid adenoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_polypoid_adenoma/common" + Adenocarcinoma in situ in a polyp, NOS: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_in_a_polyp_nos/common" + Adenocarcinoma in situ in adenomatous polyp: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_in_adenomatous_polyp/common" + Adenocarcinoma in situ in polypoid adenoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_in_polypoid_adenoma/common" + Adenocarcinoma in situ in tubular adenoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_in_tubular_adenoma/common" + Adenocarcinoma in situ in tubulovillous adenoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_in_tubulovillous_adenoma/common" + Adenocarcinoma in situ in villous adenoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_in_villous_adenoma/common" + Adenocarcinoma in situ, mucinous: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_mucinous/common" + Adenocarcinoma in situ, non-mucinous: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_nonmucinous/common" + Adenocarcinoma in situ, NOS: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_situ_nos/common" + Adenocarcinoma in tubolovillous adenoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_tubolovillous_adenoma/common" + Adenocarcinoma in tubular adenoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_tubular_adenoma/common" + Adenocarcinoma in villous adenoma: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_in_villous_adenoma/common" + Adenocarcinoma of anal ducts: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_of_anal_ducts/common" + Adenocarcinoma of anal glands: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_of_anal_glands/common" + Adenocarcinoma of rete ovarii: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_of_rete_ovarii/common" + Adenocarcinoma with apocrine metaplasia: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_with_apocrine_metaplasia/common" + Adenocarcinoma with cartilaginous and osseous metaplasia: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_with_cartilaginous_and_osseous_metaplasia/common" + Adenocarcinoma with cartilaginous metaplasia: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_with_cartilaginous_metaplasia/common" + Adenocarcinoma with mixed subtypes: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_with_mixed_subtypes/common" + Adenocarcinoma with neuroendocrine differentiation: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_with_neuroendocrine_differentiation/common" + Adenocarcinoma with osseous metaplasia: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_with_osseous_metaplasia/common" + Adenocarcinoma with spindle cell metaplasia: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_with_spindle_cell_metaplasia/common" + Adenocarcinoma with squamous metaplasia: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_with_squamous_metaplasia/common" + Adenocarcinoma, cylindroid: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_cylindroid/common" + Adenocarcinoma, diffuse type: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_diffuse_type/common" + Adenocarcinoma, endocervical type: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_endocervical_type/common" + Adenocarcinoma, intestinal type: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_intestinal_type/common" + Adenocarcinoma, metastatic, NOS: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_metastatic_nos/common" + Adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/adenocarcinoma_nos/common" + Adenocystic carcinoma: + $ref: + - "_terms_enum.yaml#/adenocystic_carcinoma/common" + Adenofibroma, NOS: + $ref: + - "_terms_enum.yaml#/adenofibroma_nos/common" + Adenoid basal carcinoma: + $ref: + - "_terms_enum.yaml#/adenoid_basal_carcinoma/common" + Adenoid cystic carcinoma: + $ref: + - "_terms_enum.yaml#/adenoid_cystic_carcinoma/common" + Adenolipoma: + $ref: + - "_terms_enum.yaml#/adenolipoma/common" + Adenolymphoma: + $ref: + - "_terms_enum.yaml#/adenolymphoma/common" + Adenoma of nipple: + $ref: + - "_terms_enum.yaml#/adenoma_of_nipple/common" + Adenoma, NOS: + $ref: + - "_terms_enum.yaml#/adenoma_nos/common" + Adenomatoid odontogenic tumor: + $ref: + - "_terms_enum.yaml#/adenomatoid_odontogenic_tumor/common" + Adenomatoid tumor, NOS: + $ref: + - "_terms_enum.yaml#/adenomatoid_tumor_nos/common" + Adenomatous polyp, NOS: + $ref: + - "_terms_enum.yaml#/adenomatous_polyp_nos/common" + Adenomatous polyposis coli: + $ref: + - "_terms_enum.yaml#/adenomatous_polyposis_coli/common" + Adenomyoma: + $ref: + - "_terms_enum.yaml#/adenomyoma/common" + Adenosarcoma: + $ref: + - "_terms_enum.yaml#/adenosarcoma/common" + Adenosquamous carcinoma: + $ref: + - "_terms_enum.yaml#/adenosquamous_carcinoma/common" + Adnexal carcinoma: + $ref: + - "_terms_enum.yaml#/adnexal_carcinoma/common" + Adnexal tumor, benign: + $ref: + - "_terms_enum.yaml#/adnexal_tumor_benign/common" + Adrenal cortical adenocarcinoma: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_adenocarcinoma/common" + Adrenal cortical adenoma, clear cell: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_adenoma_clear_cell/common" + Adrenal cortical adenoma, compact cell: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_adenoma_compact_cell/common" + Adrenal cortical adenoma, glomerulosa cell: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_adenoma_glomerulosa_cell/common" + Adrenal cortical adenoma, mixed cell: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_adenoma_mixed_cell/common" + Adrenal cortical adenoma, NOS: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_adenoma_nos/common" + Adrenal cortical adenoma, pigmented: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_adenoma_pigmented/common" + Adrenal cortical carcinoma: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_carcinoma/common" + Adrenal cortical tumor, benign: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_tumor_benign/common" + Adrenal cortical tumor, malignant: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_tumor_malignant/common" + Adrenal cortical tumor, NOS: + $ref: + - "_terms_enum.yaml#/adrenal_cortical_tumor_nos/common" + Adrenal medullary paraganglioma: + $ref: + - "_terms_enum.yaml#/adrenal_medullary_paraganglioma/common" + Adrenal medullary paraganglioma, malignant: + $ref: + - "_terms_enum.yaml#/adrenal_medullary_paraganglioma_malignant/common" + Adrenal rest tumor: + $ref: + - "_terms_enum.yaml#/adrenal_rest_tumor/common" + Adult cystic teratoma: + $ref: + - "_terms_enum.yaml#/adult_cystic_teratoma/common" + Adult granulosa cell tumor: + $ref: + - "_terms_enum.yaml#/adult_granulosa_cell_tumor/common" + Adult T-cell leukemia: + $ref: + - "_terms_enum.yaml#/adult_tcell_leukemia/common" + Adult T-cell leukemia/lymphoma (HTLV-1 positive) (includes all variants): + $ref: + - "_terms_enum.yaml#/adult_tcell_leukemialymphoma_htlv1_positive_includes_all_variants/common" + Adult T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/adult_tcell_lymphoma/common" + Adult T-cell lymphoma/leukemia: + $ref: + - "_terms_enum.yaml#/adult_tcell_lymphomaleukemia/common" + Adult teratoma, NOS: + $ref: + - "_terms_enum.yaml#/adult_teratoma_nos/common" + Aggressive angiomyxoma: + $ref: + - "_terms_enum.yaml#/aggressive_angiomyxoma/common" + Aggressive fibromatosis: + $ref: + - "_terms_enum.yaml#/aggressive_fibromatosis/common" + Aggressive NK-cell leukaemia: + $ref: + - "_terms_enum.yaml#/aggressive_nkcell_leukaemia/common" + Aggressive osteoblastoma: + $ref: + - "_terms_enum.yaml#/aggressive_osteoblastoma/common" + Aggressive systemic mastocytosis: + $ref: + - "_terms_enum.yaml#/aggressive_systemic_mastocytosis/common" + Agnogenic myeloid metaplasia: + $ref: + - "_terms_enum.yaml#/agnogenic_myeloid_metaplasia/common" + AIN III: + $ref: + - "_terms_enum.yaml#/ain_iii/common" + Aleukemic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/aleukemic_leukemia_nos/common" + Aleukemic lymphatic leukemia: + $ref: + - "_terms_enum.yaml#/aleukemic_lymphatic_leukemia/common" + Aleukemic lymphocytic leukemia: + $ref: + - "_terms_enum.yaml#/aleukemic_lymphocytic_leukemia/common" + Aleukemic lymphoid leukemia: + $ref: + - "_terms_enum.yaml#/aleukemic_lymphoid_leukemia/common" + ALK positive large B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/alk_positive_large_bcell_lymphoma/common" + Alpha cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/alpha_cell_tumor_malignant/common" + Alpha heavy chain disease: + $ref: + - "_terms_enum.yaml#/alpha_heavy_chain_disease/common" + Alveolar adenocarcinoma: + $ref: + - "_terms_enum.yaml#/alveolar_adenocarcinoma/common" + Alveolar adenoma: + $ref: + - "_terms_enum.yaml#/alveolar_adenoma/common" + Alveolar carcinoma: + $ref: + - "_terms_enum.yaml#/alveolar_carcinoma/common" + Alveolar cell carcinoma: + $ref: + - "_terms_enum.yaml#/alveolar_cell_carcinoma/common" + Alveolar rhabdomyosarcoma: + $ref: + - "_terms_enum.yaml#/alveolar_rhabdomyosarcoma/common" + Alveolar soft part sarcoma: + $ref: + - "_terms_enum.yaml#/alveolar_soft_part_sarcoma/common" + Amelanotic melanoma: + $ref: + - "_terms_enum.yaml#/amelanotic_melanoma/common" + Ameloblastic carcinoma: + $ref: + - "_terms_enum.yaml#/ameloblastic_carcinoma/common" + Ameloblastic fibro-odontoma: + $ref: + - "_terms_enum.yaml#/ameloblastic_fibroodontoma/common" + Ameloblastic fibrodentinoma: + $ref: + - "_terms_enum.yaml#/ameloblastic_fibrodentinoma/common" + Ameloblastic fibroma: + $ref: + - "_terms_enum.yaml#/ameloblastic_fibroma/common" + Ameloblastic fibrosarcoma: + $ref: + - "_terms_enum.yaml#/ameloblastic_fibrosarcoma/common" + Ameloblastic sarcoma: + $ref: + - "_terms_enum.yaml#/ameloblastic_sarcoma/common" + Ameloblastoma, malignant: + $ref: + - "_terms_enum.yaml#/ameloblastoma_malignant/common" + Ameloblastoma, NOS: + $ref: + - "_terms_enum.yaml#/ameloblastoma_nos/common" + AML M6: + $ref: + - "_terms_enum.yaml#/aml_m6/common" + Anal intraepithelial neoplasia, grade III: + $ref: + - "_terms_enum.yaml#/anal_intraepithelial_neoplasia_grade_iii/common" + Anaplastic astrocytoma, IDH-mutant: + $ref: + - "_terms_enum.yaml#/anaplastic_astrocytoma_idhmutant/common" + Anaplastic astrocytoma, IDH-wildtype: + $ref: + - "_terms_enum.yaml#/anaplastic_astrocytoma_idhwildtype/common" + Anaplastic large B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/anaplastic_large_bcell_lymphoma/common" + Anaplastic large cell lymphoma, ALK negative: + $ref: + - "_terms_enum.yaml#/anaplastic_large_cell_lymphoma_alk_negative/common" + Anaplastic large cell lymphoma, ALK positive: + $ref: + - "_terms_enum.yaml#/anaplastic_large_cell_lymphoma_alk_positive/common" + Anaplastic large cell lymphoma, CD30+: + $ref: + - "_terms_enum.yaml#/anaplastic_large_cell_lymphoma_cd30/common" + Anaplastic large cell lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/anaplastic_large_cell_lymphoma_nos/common" + Anaplastic medulloblastoma: + $ref: + - "_terms_enum.yaml#/anaplastic_medulloblastoma/common" + Anaplastic oligoastrocytoma: + $ref: + - "_terms_enum.yaml#/anaplastic_oligoastrocytoma/common" + Anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted: + $ref: + - "_terms_enum.yaml#/anaplastic_oligodendroglioma_idhmutant_and_1p19qcodeleted/common" + Anaplastic pleomorphic xanthroastrocytoma: + $ref: + - "_terms_enum.yaml#/anaplastic_pleomorphic_xanthroastrocytoma/common" + Ancient schwannoma: + $ref: + - "_terms_enum.yaml#/ancient_schwannoma/common" + Androblastoma, benign: + $ref: + - "_terms_enum.yaml#/androblastoma_benign/common" + Androblastoma, malignant: + $ref: + - "_terms_enum.yaml#/androblastoma_malignant/common" + Androblastoma, NOS: + $ref: + - "_terms_enum.yaml#/androblastoma_nos/common" + Angioblastoma: + $ref: + - "_terms_enum.yaml#/angioblastoma/common" + Angiocentric glioma: + $ref: + - "_terms_enum.yaml#/angiocentric_glioma/common" + Angiocentric immunoproliferative lesion: + $ref: + - "_terms_enum.yaml#/angiocentric_immunoproliferative_lesion/common" + Angiocentric T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/angiocentric_tcell_lymphoma/common" + Angioendothelioma: + $ref: + - "_terms_enum.yaml#/angioendothelioma/common" + Angioendotheliomatosis: + $ref: + - "_terms_enum.yaml#/angioendotheliomatosis/common" + Angiofibroma, NOS: + $ref: + - "_terms_enum.yaml#/angiofibroma_nos/common" + Angioimmunoblastic lymphadenopathy: + $ref: + - "_terms_enum.yaml#/angioimmunoblastic_lymphadenopathy/common" + Angioimmunoblastic lymphoma: + $ref: + - "_terms_enum.yaml#/angioimmunoblastic_lymphoma/common" + Angioimmunoblastic T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/angioimmunoblastic_tcell_lymphoma/common" + Angiokeratoma: + $ref: + - "_terms_enum.yaml#/angiokeratoma/common" + Angioleiomyoma: + $ref: + - "_terms_enum.yaml#/angioleiomyoma/common" + Angiolipoma, NOS: + $ref: + - "_terms_enum.yaml#/angiolipoma_nos/common" + Angioma, NOS: + $ref: + - "_terms_enum.yaml#/angioma_nos/common" + Angiomatoid fibrous histiocytoma: + $ref: + - "_terms_enum.yaml#/angiomatoid_fibrous_histiocytoma/common" + Angiomatous meningioma: + $ref: + - "_terms_enum.yaml#/angiomatous_meningioma/common" + Angiomyofibroblastoma: + $ref: + - "_terms_enum.yaml#/angiomyofibroblastoma/common" + Angiomyolipoma: + $ref: + - "_terms_enum.yaml#/angiomyolipoma/common" + Angiomyoma: + $ref: + - "_terms_enum.yaml#/angiomyoma/common" + Angiomyosarcoma: + $ref: + - "_terms_enum.yaml#/angiomyosarcoma/common" + Angiomyxoma: + $ref: + - "_terms_enum.yaml#/angiomyxoma/common" + Angiosarcoma: + $ref: + - "_terms_enum.yaml#/angiosarcoma/common" + Angiotropic lymphoma: + $ref: + - "_terms_enum.yaml#/angiotropic_lymphoma/common" + Aortic body paraganglioma: + $ref: + - "_terms_enum.yaml#/aortic_body_paraganglioma/common" + Aortic body tumor: + $ref: + - "_terms_enum.yaml#/aortic_body_tumor/common" + Aorticopulmonary paraganglioma: + $ref: + - "_terms_enum.yaml#/aorticopulmonary_paraganglioma/common" + Apocrine adenoma: + $ref: + - "_terms_enum.yaml#/apocrine_adenoma/common" + Apocrine cystadenoma: + $ref: + - "_terms_enum.yaml#/apocrine_cystadenoma/common" + Apudoma: + $ref: + - "_terms_enum.yaml#/apudoma/common" + Arrhenoblastoma, benign: + $ref: + - "_terms_enum.yaml#/arrhenoblastoma_benign/common" + Arrhenoblastoma, malignant: + $ref: + - "_terms_enum.yaml#/arrhenoblastoma_malignant/common" + Arrhenoblastoma, NOS: + $ref: + - "_terms_enum.yaml#/arrhenoblastoma_nos/common" + Arteriovenous hemangioma: + $ref: + - "_terms_enum.yaml#/arteriovenous_hemangioma/common" + Askin tumor: + $ref: + - "_terms_enum.yaml#/askin_tumor/common" + Astroblastoma: + $ref: + - "_terms_enum.yaml#/astroblastoma/common" + Astrocytic glioma: + $ref: + - "_terms_enum.yaml#/astrocytic_glioma/common" + Astrocytoma, anaplastic: + $ref: + - "_terms_enum.yaml#/astrocytoma_anaplastic/common" + Astrocytoma, low grade: + $ref: + - "_terms_enum.yaml#/astrocytoma_low_grade/common" + Astrocytoma, NOS: + $ref: + - "_terms_enum.yaml#/astrocytoma_nos/common" + Astroglioma: + $ref: + - "_terms_enum.yaml#/astroglioma/common" + Atypical adenoma: + $ref: + - "_terms_enum.yaml#/atypical_adenoma/common" + Atypical carcinoid tumor: + $ref: + - "_terms_enum.yaml#/atypical_carcinoid_tumor/common" + Atypical choroid plexus papilloma: + $ref: + - "_terms_enum.yaml#/atypical_choroid_plexus_papilloma/common" + Atypical chronic myeloid leukemia, BCR/ABL negative: + $ref: + - "_terms_enum.yaml#/atypical_chronic_myeloid_leukemia_bcrabl_negative/common" + Atypical chronic myeloid leukemia, Philadelphia chromosome (Ph1) negative: + $ref: + - "_terms_enum.yaml#/atypical_chronic_myeloid_leukemia_philadelphia_chromosome_ph1_negative/common" + Atypical fibrous histiocytoma: + $ref: + - "_terms_enum.yaml#/atypical_fibrous_histiocytoma/common" + Atypical fibroxanthoma: + $ref: + - "_terms_enum.yaml#/atypical_fibroxanthoma/common" + Atypical follicular adenoma: + $ref: + - "_terms_enum.yaml#/atypical_follicular_adenoma/common" + Atypical leiomyoma: + $ref: + - "_terms_enum.yaml#/atypical_leiomyoma/common" + Atypical lipoma: + $ref: + - "_terms_enum.yaml#/atypical_lipoma/common" + Atypical meningioma: + $ref: + - "_terms_enum.yaml#/atypical_meningioma/common" + Atypical polypoid adenomyoma: + $ref: + - "_terms_enum.yaml#/atypical_polypoid_adenomyoma/common" + Atypical proliferating serous tumor: + $ref: + - "_terms_enum.yaml#/atypical_proliferating_serous_tumor/common" + Atypical proliferative endometrioid tumor: + $ref: + - "_terms_enum.yaml#/atypical_proliferative_endometrioid_tumor/common" + Atypical proliferative papillary serous tumor: + $ref: + - "_terms_enum.yaml#/atypical_proliferative_papillary_serous_tumor/common" + Atypical teratoid/rhabdoid tumor: + $ref: + - "_terms_enum.yaml#/atypical_teratoidrhabdoid_tumor/common" + B lymphoblastic leukemia/lymphoma with hyperdiploidy: + $ref: + - "_terms_enum.yaml#/b_lymphoblastic_leukemialymphoma_with_hyperdiploidy/common" + B lymphoblastic leukemia/lymphoma with hypodiploidy (Hypodiploid ALL): + $ref: + - "_terms_enum.yaml#/b_lymphoblastic_leukemialymphoma_with_hypodiploidy_hypodiploid_all/common" + B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1): + $ref: + - "_terms_enum.yaml#/b_lymphoblastic_leukemialymphoma_with_t119q23p133_e2apbx1_tcf3pbx1/common" + B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32); IL3-IGH: + $ref: + - "_terms_enum.yaml#/b_lymphoblastic_leukemialymphoma_with_t514q31q32_il3igh/common" + B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2); BCR-ABL1: + $ref: + - "_terms_enum.yaml#/b_lymphoblastic_leukemialymphoma_with_t922q34q112_bcrabl1/common" + B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1): + $ref: + - "_terms_enum.yaml#/b_lymphoblastic_leukemialymphoma_with_t1221p13q22_telaml1_etv6runx1/common" + B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged: + $ref: + - "_terms_enum.yaml#/b_lymphoblastic_leukemialymphoma_with_tv11q23_mll_rearranged/common" + B lymphoblastic leukemia/lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/b_lymphoblastic_leukemialymphoma_nos/common" + B-ALL: + $ref: + - "_terms_enum.yaml#/ball/common" + B-cell lymphocytic leukemia/small lymphocytic lymphoma: + $ref: + - "_terms_enum.yaml#/bcell_lymphocytic_leukemiasmall_lymphocytic_lymphoma/common" + B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma: + $ref: + - "_terms_enum.yaml#/bcell_lymphoma_unclassifiable_with_features_intermediate_between_diffuse_large_bcell_lymphoma_and_burkitt_lymphoma/common" + B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: + $ref: + - "_terms_enum.yaml#/bcell_lymphoma_unclassifiable_with_features_intermediate_between_diffuse_large_bcell_lymphoma_and_classical_hodgkin_lymphoma/common" + Balloon cell melanoma: + $ref: + - "_terms_enum.yaml#/balloon_cell_melanoma/common" + Balloon cell nevus: + $ref: + - "_terms_enum.yaml#/balloon_cell_nevus/common" + BALT lymphoma: + $ref: + - "_terms_enum.yaml#/balt_lymphoma/common" + Basal cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/basal_cell_adenocarcinoma/common" + Basal cell adenoma: + $ref: + - "_terms_enum.yaml#/basal_cell_adenoma/common" + Basal cell carcinoma, desmoplastic type: + $ref: + - "_terms_enum.yaml#/basal_cell_carcinoma_desmoplastic_type/common" + Basal cell carcinoma, fibroepithelial: + $ref: + - "_terms_enum.yaml#/basal_cell_carcinoma_fibroepithelial/common" + Basal cell carcinoma, micronodular: + $ref: + - "_terms_enum.yaml#/basal_cell_carcinoma_micronodular/common" + Basal cell carcinoma, morpheic: + $ref: + - "_terms_enum.yaml#/basal_cell_carcinoma_morpheic/common" + Basal cell carcinoma, nodular: + $ref: + - "_terms_enum.yaml#/basal_cell_carcinoma_nodular/common" + Basal cell carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/basal_cell_carcinoma_nos/common" + Basal cell epithelioma: + $ref: + - "_terms_enum.yaml#/basal_cell_epithelioma/common" + Basal cell tumor: + $ref: + - "_terms_enum.yaml#/basal_cell_tumor/common" + Basaloid carcinoma: + $ref: + - "_terms_enum.yaml#/basaloid_carcinoma/common" + Basaloid squamous cell carcinoma: + $ref: + - "_terms_enum.yaml#/basaloid_squamous_cell_carcinoma/common" + Basophil adenocarcinoma: + $ref: + - "_terms_enum.yaml#/basophil_adenocarcinoma/common" + Basophil adenoma: + $ref: + - "_terms_enum.yaml#/basophil_adenoma/common" + Basophil carcinoma: + $ref: + - "_terms_enum.yaml#/basophil_carcinoma/common" + Basosquamous carcinoma: + $ref: + - "_terms_enum.yaml#/basosquamous_carcinoma/common" + Bednar tumor: + $ref: + - "_terms_enum.yaml#/bednar_tumor/common" + Bellini duct carcinoma: + $ref: + - "_terms_enum.yaml#/bellini_duct_carcinoma/common" + Benign cystic nephroma: + $ref: + - "_terms_enum.yaml#/benign_cystic_nephroma/common" + Benign fibrous histiocytoma: + $ref: + - "_terms_enum.yaml#/benign_fibrous_histiocytoma/common" + Beta cell adenoma: + $ref: + - "_terms_enum.yaml#/beta_cell_adenoma/common" + Beta cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/beta_cell_tumor_malignant/common" + Bile duct adenocarcinoma: + $ref: + - "_terms_enum.yaml#/bile_duct_adenocarcinoma/common" + Bile duct adenoma: + $ref: + - "_terms_enum.yaml#/bile_duct_adenoma/common" + Bile duct carcinoma: + $ref: + - "_terms_enum.yaml#/bile_duct_carcinoma/common" + Bile duct cystadenocarcinoma: + $ref: + - "_terms_enum.yaml#/bile_duct_cystadenocarcinoma/common" + Bile duct cystadenoma: + $ref: + - "_terms_enum.yaml#/bile_duct_cystadenoma/common" + Biliary intraepithelial neoplasia, grade 3: + $ref: + - "_terms_enum.yaml#/biliary_intraepithelial_neoplasia_grade_3/common" + Biliary papillomatosis: + $ref: + - "_terms_enum.yaml#/biliary_papillomatosis/common" + Bizarre leiomyoma: + $ref: + - "_terms_enum.yaml#/bizarre_leiomyoma/common" + Black adenoma: + $ref: + - "_terms_enum.yaml#/black_adenoma/common" + Blast cell leukemia: + $ref: + - "_terms_enum.yaml#/blast_cell_leukemia/common" + Blastic NK cell lymphoma: + $ref: + - "_terms_enum.yaml#/blastic_nk_cell_lymphoma/common" + Blastic plasmacytoid dendritic cell neoplasm: + $ref: + - "_terms_enum.yaml#/blastic_plasmacytoid_dendritic_cell_neoplasm/common" + Blastoma, NOS: + $ref: + - "_terms_enum.yaml#/blastoma_nos/common" + Blue nevus, malignant: + $ref: + - "_terms_enum.yaml#/blue_nevus_malignant/common" + Blue nevus, NOS: + $ref: + - "_terms_enum.yaml#/blue_nevus_nos/common" + Botryoid sarcoma: + $ref: + - "_terms_enum.yaml#/botryoid_sarcoma/common" + Bowen disease: + $ref: + - "_terms_enum.yaml#/bowen_disease/common" + Brenner tumor, borderline malignancy: + $ref: + - "_terms_enum.yaml#/brenner_tumor_borderline_malignancy/common" + Brenner tumor, malignant: + $ref: + - "_terms_enum.yaml#/brenner_tumor_malignant/common" + Brenner tumor, NOS: + $ref: + - "_terms_enum.yaml#/brenner_tumor_nos/common" + Brenner tumor, proliferating: + $ref: + - "_terms_enum.yaml#/brenner_tumor_proliferating/common" + Bronchial adenoma, NOS: + $ref: + - "_terms_enum.yaml#/bronchial_adenoma_nos/common" + Bronchial-associated lymphoid tissue lymphoma: + $ref: + - "_terms_enum.yaml#/bronchialassociated_lymphoid_tissue_lymphoma/common" + Bronchio-alveolar carcinoma, mixed mucinous and non-mucinous: + $ref: + - "_terms_enum.yaml#/bronchioalveolar_carcinoma_mixed_mucinous_and_nonmucinous/common" + Bronchio-alveolar carcinoma, mucinous: + $ref: + - "_terms_enum.yaml#/bronchioalveolar_carcinoma_mucinous/common" + Bronchiolar adenocarcinoma: + $ref: + - "_terms_enum.yaml#/bronchiolar_adenocarcinoma/common" + Bronchiolar carcinoma: + $ref: + - "_terms_enum.yaml#/bronchiolar_carcinoma/common" + Bronchiolo-alveolar adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_adenocarcinoma_nos/common" + Bronchiolo-alveolar carcinoma, Clara cell: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_carcinoma_clara_cell/common" + Bronchiolo-alveolar carcinoma, Clara cell and goblet cell type: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_carcinoma_clara_cell_and_goblet_cell_type/common" + Bronchiolo-alveolar carcinoma, goblet cell type: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_carcinoma_goblet_cell_type/common" + Bronchiolo-alveolar carcinoma, indeterminate type: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_carcinoma_indeterminate_type/common" + Bronchiolo-alveolar carcinoma, non-mucinous: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_carcinoma_nonmucinous/common" + Bronchiolo-alveolar carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_carcinoma_nos/common" + Bronchiolo-alveolar carcinoma, type II pneumocyte and goblet cell type: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_carcinoma_type_ii_pneumocyte_and_goblet_cell_type/common" + Bronchiolo-alveolar carcinoma; type II pneumocyte: + $ref: + - "_terms_enum.yaml#/bronchioloalveolar_carcinoma_type_ii_pneumocyte/common" + Brooke tumor: + $ref: + - "_terms_enum.yaml#/brooke_tumor/common" + Brown fat tumor: + $ref: + - "_terms_enum.yaml#/brown_fat_tumor/common" + Burkitt cell leukemia: + $ref: + - "_terms_enum.yaml#/burkitt_cell_leukemia/common" + Burkitt lymphoma, NOS (Includes all variants): + $ref: + - "_terms_enum.yaml#/burkitt_lymphoma_nos_includes_all_variants/common" + Burkitt tumor: + $ref: + - "_terms_enum.yaml#/burkitt_tumor/common" + Burkitt-like lymphoma: + $ref: + - "_terms_enum.yaml#/burkittlike_lymphoma/common" + C cell carcinoma: + $ref: + - "_terms_enum.yaml#/c_cell_carcinoma/common" + c-ALL: + $ref: + - "_terms_enum.yaml#/call/common" + Calcifying epithelial odontogenic tumor: + $ref: + - "_terms_enum.yaml#/calcifying_epithelial_odontogenic_tumor/common" + Calcifying epithelioma of Malherbe: + $ref: + - "_terms_enum.yaml#/calcifying_epithelioma_of_malherbe/common" + Calcifying odontogenic cyst: + $ref: + - "_terms_enum.yaml#/calcifying_odontogenic_cyst/common" + Cancer: + $ref: + - "_terms_enum.yaml#/cancer/common" + Capillary hemangioma: + $ref: + - "_terms_enum.yaml#/capillary_hemangioma/common" + Carcinoid tumor of uncertain malignant potential: + $ref: + - "_terms_enum.yaml#/carcinoid_tumor_of_uncertain_malignant_potential/common" + Carcinoid tumor, NOS: + $ref: + - "_terms_enum.yaml#/carcinoid_tumor_nos/common" + Carcinoid, NOS: + $ref: + - "_terms_enum.yaml#/carcinoid_nos/common" + Carcinoma in a polyp, NOS: + $ref: + - "_terms_enum.yaml#/carcinoma_in_a_polyp_nos/common" + Carcinoma in adenomatous polyp: + $ref: + - "_terms_enum.yaml#/carcinoma_in_adenomatous_polyp/common" + Carcinoma in pleomorphic adenoma: + $ref: + - "_terms_enum.yaml#/carcinoma_in_pleomorphic_adenoma/common" + Carcinoma in situ in a polyp, NOS: + $ref: + - "_terms_enum.yaml#/carcinoma_in_situ_in_a_polyp_nos/common" + Carcinoma in situ in adenomatous polyp: + $ref: + - "_terms_enum.yaml#/carcinoma_in_situ_in_adenomatous_polyp/common" + Carcinoma in situ, NOS: + $ref: + - "_terms_enum.yaml#/carcinoma_in_situ_nos/common" + Carcinoma showing thymus-like differentiation: + $ref: + - "_terms_enum.yaml#/carcinoma_showing_thymuslike_differentiation/common" + Carcinoma showing thymus-like element: + $ref: + - "_terms_enum.yaml#/carcinoma_showing_thymuslike_element/common" + Carcinoma simplex: + $ref: + - "_terms_enum.yaml#/carcinoma_simplex/common" + Carcinoma with apocrine metaplasia: + $ref: + - "_terms_enum.yaml#/carcinoma_with_apocrine_metaplasia/common" + Carcinoma with chondroid differentiation: + $ref: + - "_terms_enum.yaml#/carcinoma_with_chondroid_differentiation/common" + Carcinoma with neuroendocrine differentiation: + $ref: + - "_terms_enum.yaml#/carcinoma_with_neuroendocrine_differentiation/common" + Carcinoma with osseous differentiation: + $ref: + - "_terms_enum.yaml#/carcinoma_with_osseous_differentiation/common" + Carcinoma with productive fibrosis: + $ref: + - "_terms_enum.yaml#/carcinoma_with_productive_fibrosis/common" + Carcinoma, anaplastic, NOS: + $ref: + - "_terms_enum.yaml#/carcinoma_anaplastic_nos/common" + Carcinoma, diffuse type: + $ref: + - "_terms_enum.yaml#/carcinoma_diffuse_type/common" + Carcinoma, intestinal type: + $ref: + - "_terms_enum.yaml#/carcinoma_intestinal_type/common" + Carcinoma, metastatic, NOS: + $ref: + - "_terms_enum.yaml#/carcinoma_metastatic_nos/common" + Carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/carcinoma_nos/common" + Carcinoma, undifferentiated, NOS: + $ref: + - "_terms_enum.yaml#/carcinoma_undifferentiated_nos/common" + Carcinomatosis: + $ref: + - "_terms_enum.yaml#/carcinomatosis/common" + Carcinosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/carcinosarcoma_nos/common" + Carotid body paraganglioma: + $ref: + - "_terms_enum.yaml#/carotid_body_paraganglioma/common" + Carotid body tumor: + $ref: + - "_terms_enum.yaml#/carotid_body_tumor/common" + Cartilaginous exostosis: + $ref: + - "_terms_enum.yaml#/cartilaginous_exostosis/common" + CASTLE: + $ref: + - "_terms_enum.yaml#/castle/common" + Cavernous hemangioma: + $ref: + - "_terms_enum.yaml#/cavernous_hemangioma/common" + Cavernous lymphangioma: + $ref: + - "_terms_enum.yaml#/cavernous_lymphangioma/common" + Cellular angiofibroma: + $ref: + - "_terms_enum.yaml#/cellular_angiofibroma/common" + Cellular blue nevus: + $ref: + - "_terms_enum.yaml#/cellular_blue_nevus/common" + Cellular ependymoma: + $ref: + - "_terms_enum.yaml#/cellular_ependymoma/common" + Cellular fibroma: + $ref: + - "_terms_enum.yaml#/cellular_fibroma/common" + Cellular leiomyoma: + $ref: + - "_terms_enum.yaml#/cellular_leiomyoma/common" + Cellular schwannoma: + $ref: + - "_terms_enum.yaml#/cellular_schwannoma/common" + Cementifying fibroma: + $ref: + - "_terms_enum.yaml#/cementifying_fibroma/common" + Cemento-ossifying fibroma: + $ref: + - "_terms_enum.yaml#/cementoossifying_fibroma/common" + Cementoblastoma, benign: + $ref: + - "_terms_enum.yaml#/cementoblastoma_benign/common" + Cementoma, NOS: + $ref: + - "_terms_enum.yaml#/cementoma_nos/common" + Central neuroblastoma: + $ref: + - "_terms_enum.yaml#/central_neuroblastoma/common" + Central neurocytoma: + $ref: + - "_terms_enum.yaml#/central_neurocytoma/common" + Central odontogenic fibroma: + $ref: + - "_terms_enum.yaml#/central_odontogenic_fibroma/common" + Central osteosarcoma: + $ref: + - "_terms_enum.yaml#/central_osteosarcoma/common" + Central primitive neuroectodermal tumor, NOS: + $ref: + - "_terms_enum.yaml#/central_primitive_neuroectodermal_tumor_nos/common" + Cerebellar liponeurocytoma: + $ref: + - "_terms_enum.yaml#/cerebellar_liponeurocytoma/common" + Cerebellar sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/cerebellar_sarcoma_nos/common" + Ceruminous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/ceruminous_adenocarcinoma/common" + Ceruminous adenoma: + $ref: + - "_terms_enum.yaml#/ceruminous_adenoma/common" + Ceruminous carcinoma: + $ref: + - "_terms_enum.yaml#/ceruminous_carcinoma/common" + Cervical intraepithelial neoplasia, grade III: + $ref: + - "_terms_enum.yaml#/cervical_intraepithelial_neoplasia_grade_iii/common" + Cervical intraepithelial neoplasia, low grade: + $ref: + - "_terms_enum.yaml#/cervical_intraepithelial_neoplasia_low_grade/common" + Chemodectoma: + $ref: + - "_terms_enum.yaml#/chemodectoma/common" + Chief cell adenoma: + $ref: + - "_terms_enum.yaml#/chief_cell_adenoma/common" + Chloroma: + $ref: + - "_terms_enum.yaml#/chloroma/common" + Cholangiocarcinoma: + $ref: + - "_terms_enum.yaml#/cholangiocarcinoma/common" + Cholangioma: + $ref: + - "_terms_enum.yaml#/cholangioma/common" + Chondroblastic osteosarcoma: + $ref: + - "_terms_enum.yaml#/chondroblastic_osteosarcoma/common" + Chondroblastoma, NOS: + $ref: + - "_terms_enum.yaml#/chondroblastoma_nos/common" + Chondroid chordoma: + $ref: + - "_terms_enum.yaml#/chondroid_chordoma/common" + Chondroid lipoma: + $ref: + - "_terms_enum.yaml#/chondroid_lipoma/common" + Chondroid syringoma: + $ref: + - "_terms_enum.yaml#/chondroid_syringoma/common" + Chondroma, NOS: + $ref: + - "_terms_enum.yaml#/chondroma_nos/common" + Chondromatosis, NOS: + $ref: + - "_terms_enum.yaml#/chondromatosis_nos/common" + Chondromatous giant cell tumor: + $ref: + - "_terms_enum.yaml#/chondromatous_giant_cell_tumor/common" + Chondromyxoid fibroma: + $ref: + - "_terms_enum.yaml#/chondromyxoid_fibroma/common" + Chondrosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/chondrosarcoma_nos/common" + Chordoid glioma: + $ref: + - "_terms_enum.yaml#/chordoid_glioma/common" + Chordoid glioma of third ventricle: + $ref: + - "_terms_enum.yaml#/chordoid_glioma_of_third_ventricle/common" + Chordoid meningioma: + $ref: + - "_terms_enum.yaml#/chordoid_meningioma/common" + Chordoma, NOS: + $ref: + - "_terms_enum.yaml#/chordoma_nos/common" + Chorioadenoma: + $ref: + - "_terms_enum.yaml#/chorioadenoma/common" + Chorioadenoma destruens: + $ref: + - "_terms_enum.yaml#/chorioadenoma_destruens/common" + Chorioangioma: + $ref: + - "_terms_enum.yaml#/chorioangioma/common" + Choriocarcinoma combined with embryonal carcinoma: + $ref: + - "_terms_enum.yaml#/choriocarcinoma_combined_with_embryonal_carcinoma/common" + Choriocarcinoma combined with other germ cell elements: + $ref: + - "_terms_enum.yaml#/choriocarcinoma_combined_with_other_germ_cell_elements/common" + Choriocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/choriocarcinoma_nos/common" + Chorioepithelioma: + $ref: + - "_terms_enum.yaml#/chorioepithelioma/common" + Chorionepithelioma: + $ref: + - "_terms_enum.yaml#/chorionepithelioma/common" + Choroid plexus carcinoma: + $ref: + - "_terms_enum.yaml#/choroid_plexus_carcinoma/common" + Choroid plexus papilloma, anaplastic: + $ref: + - "_terms_enum.yaml#/choroid_plexus_papilloma_anaplastic/common" + Choroid plexus papilloma, malignant: + $ref: + - "_terms_enum.yaml#/choroid_plexus_papilloma_malignant/common" + Choroid plexus papilloma, NOS: + $ref: + - "_terms_enum.yaml#/choroid_plexus_papilloma_nos/common" + Chromaffin paraganglioma: + $ref: + - "_terms_enum.yaml#/chromaffin_paraganglioma/common" + Chromaffin tumor: + $ref: + - "_terms_enum.yaml#/chromaffin_tumor/common" + Chromaffinoma: + $ref: + - "_terms_enum.yaml#/chromaffinoma/common" + Chromophobe adenocarcinoma: + $ref: + - "_terms_enum.yaml#/chromophobe_adenocarcinoma/common" + Chromophobe adenoma: + $ref: + - "_terms_enum.yaml#/chromophobe_adenoma/common" + Chromophobe carcinoma: + $ref: + - "_terms_enum.yaml#/chromophobe_carcinoma/common" + Chromophobe cell renal carcinoma: + $ref: + - "_terms_enum.yaml#/chromophobe_cell_renal_carcinoma/common" + Chronic eosinophilic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/chronic_eosinophilic_leukemia_nos/common" + Chronic granulocytic leukemia, BCR/ABL: + $ref: + - "_terms_enum.yaml#/chronic_granulocytic_leukemia_bcrabl/common" + Chronic granulocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/chronic_granulocytic_leukemia_nos/common" + Chronic granulocytic leukemia, Philadelphia chromosome (Ph1) positive: + $ref: + - "_terms_enum.yaml#/chronic_granulocytic_leukemia_philadelphia_chromosome_ph1_positive/common" + Chronic granulocytic leukemia, t(9;22)(q34;q11): + $ref: + - "_terms_enum.yaml#/chronic_granulocytic_leukemia_t922q34q11/common" + Chronic idiopathic myelofibrosis: + $ref: + - "_terms_enum.yaml#/chronic_idiopathic_myelofibrosis/common" + Chronic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/chronic_leukemia_nos/common" + Chronic lymphatic leukemia: + $ref: + - "_terms_enum.yaml#/chronic_lymphatic_leukemia/common" + Chronic lymphocytic leukemia: + $ref: + - "_terms_enum.yaml#/chronic_lymphocytic_leukemia/common" + Chronic lymphocytic leukemia, B-cell type (includes all variants of BCLL): + $ref: + - "_terms_enum.yaml#/chronic_lymphocytic_leukemia_bcell_type_includes_all_variants_of_bcll/common" + Chronic lymphoid leukemia: + $ref: + - "_terms_enum.yaml#/chronic_lymphoid_leukemia/common" + Chronic lymphoproliferative disorder of NK cells: + $ref: + - "_terms_enum.yaml#/chronic_lymphoproliferative_disorder_of_nk_cells/common" + Chronic monocytic leukemia: + $ref: + - "_terms_enum.yaml#/chronic_monocytic_leukemia/common" + Chronic myelocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/chronic_myelocytic_leukemia_nos/common" + Chronic myelogenous leukemia, BCR-ABL positive: + $ref: + - "_terms_enum.yaml#/chronic_myelogenous_leukemia_bcrabl_positive/common" + Chronic myelogenous leukemia, Philadelphia chromosome (Ph 1) positive: + $ref: + - "_terms_enum.yaml#/chronic_myelogenous_leukemia_philadelphia_chromosome_ph_1_positive/common" + Chronic myelogenous leukemia, t(9;22)(q34;q11): + $ref: + - "_terms_enum.yaml#/chronic_myelogenous_leukemia_t922q34q11/common" + Chronic myeloid leukemia, NOS: + $ref: + - "_terms_enum.yaml#/chronic_myeloid_leukemia_nos/common" + Chronic myelomonocytic leukemia in transformation: + $ref: + - "_terms_enum.yaml#/chronic_myelomonocytic_leukemia_in_transformation/common" + Chronic myelomonocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/chronic_myelomonocytic_leukemia_nos/common" + Chronic myeloproliferative disease, NOS: + $ref: + - "_terms_enum.yaml#/chronic_myeloproliferative_disease_nos/common" + Chronic myeloproliferative disorder: + $ref: + - "_terms_enum.yaml#/chronic_myeloproliferative_disorder/common" + Chronic neutrophilic leukemia: + $ref: + - "_terms_enum.yaml#/chronic_neutrophilic_leukemia/common" + CIN III with severe dysplasia: + $ref: + - "_terms_enum.yaml#/cin_iii_with_severe_dysplasia/common" + Cin III, NOS: + $ref: + - "_terms_enum.yaml#/cin_iii_nos/common" + Circumscribed arachnoidal cerebellar sarcoma: + $ref: + - "_terms_enum.yaml#/circumscribed_arachnoidal_cerebellar_sarcoma/common" + Classical Hodgkin lymphoma, lymphocyte depletion, NOS: + $ref: + - "_terms_enum.yaml#/classical_hodgkin_lymphoma_lymphocyte_depletion_nos/common" + Classical Hodgkin lymphoma, lymphocyte-rich: + $ref: + - "_terms_enum.yaml#/classical_hodgkin_lymphoma_lymphocyterich/common" + Classical Hodgkin lymphoma, mixed cellularity, NOS: + $ref: + - "_terms_enum.yaml#/classical_hodgkin_lymphoma_mixed_cellularity_nos/common" + Classical Hodgkin lymphoma, nodular sclerosis, cellular phase: + $ref: + - "_terms_enum.yaml#/classical_hodgkin_lymphoma_nodular_sclerosis_cellular_phase/common" + Classical Hodgkin lymphoma, nodular sclerosis, grade 1: + $ref: + - "_terms_enum.yaml#/classical_hodgkin_lymphoma_nodular_sclerosis_grade_1/common" + Classical Hodgkin lymphoma, nodular sclerosis, grade 2: + $ref: + - "_terms_enum.yaml#/classical_hodgkin_lymphoma_nodular_sclerosis_grade_2/common" + Classical Hodgkin lymphoma, nodular sclerosis, NOS: + $ref: + - "_terms_enum.yaml#/classical_hodgkin_lymphoma_nodular_sclerosis_nos/common" + Clear cell (glycogen-rich) urothelial carcinoma: + $ref: + - "_terms_enum.yaml#/clear_cell_glycogenrich_urothelial_carcinoma/common" + Clear cell adenocarcinoma, mesonephroid: + $ref: + - "_terms_enum.yaml#/clear_cell_adenocarcinoma_mesonephroid/common" + Clear cell adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/clear_cell_adenocarcinoma_nos/common" + Clear cell adenofibroma: + $ref: + - "_terms_enum.yaml#/clear_cell_adenofibroma/common" + Clear cell adenoma: + $ref: + - "_terms_enum.yaml#/clear_cell_adenoma/common" + Clear cell carcinoma: + $ref: + - "_terms_enum.yaml#/clear_cell_carcinoma/common" + Clear cell chondrosarcoma: + $ref: + - "_terms_enum.yaml#/clear_cell_chondrosarcoma/common" + Clear cell cystadenofibroma: + $ref: + - "_terms_enum.yaml#/clear_cell_cystadenofibroma/common" + Clear cell ependymoma: + $ref: + - "_terms_enum.yaml#/clear_cell_ependymoma/common" + Clear cell hidradenoma: + $ref: + - "_terms_enum.yaml#/clear_cell_hidradenoma/common" + Clear cell meningioma: + $ref: + - "_terms_enum.yaml#/clear_cell_meningioma/common" + Clear cell odontogenic carcinoma: + $ref: + - "_terms_enum.yaml#/clear_cell_odontogenic_carcinoma/common" + Clear cell odontogenic tumor: + $ref: + - "_terms_enum.yaml#/clear_cell_odontogenic_tumor/common" + Clear cell sarcoma of kidney: + $ref: + - "_terms_enum.yaml#/clear_cell_sarcoma_of_kidney/common" + Clear cell sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/clear_cell_sarcoma_nos/common" + Clear cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/clear_cell_tumor_nos/common" + Cloacogenic carcinoma: + $ref: + - "_terms_enum.yaml#/cloacogenic_carcinoma/common" + CNS Embryonal tumor with rhabdoid features: + $ref: + - "_terms_enum.yaml#/cns_embryonal_tumor_with_rhabdoid_features/common" + Codman tumor: + $ref: + - "_terms_enum.yaml#/codman_tumor/common" + Collecting duct carcinoma: + $ref: + - "_terms_enum.yaml#/collecting_duct_carcinoma/common" + Colloid adenocarcinoma: + $ref: + - "_terms_enum.yaml#/colloid_adenocarcinoma/common" + Colloid adenoma: + $ref: + - "_terms_enum.yaml#/colloid_adenoma/common" + Colloid carcinoma: + $ref: + - "_terms_enum.yaml#/colloid_carcinoma/common" + Combined carcinoid and adenocarcinoma: + $ref: + - "_terms_enum.yaml#/combined_carcinoid_and_adenocarcinoma/common" + Combined hepatocellular carcinoma and cholangiocarcinoma: + $ref: + - "_terms_enum.yaml#/combined_hepatocellular_carcinoma_and_cholangiocarcinoma/common" + Combined large cell neuroendocrine carcinoma: + $ref: + - "_terms_enum.yaml#/combined_large_cell_neuroendocrine_carcinoma/common" + Combined small cell carcinoma: + $ref: + - "_terms_enum.yaml#/combined_small_cell_carcinoma/common" + Combined small cell-adenocarcinoma: + $ref: + - "_terms_enum.yaml#/combined_small_celladenocarcinoma/common" + Combined small cell-squamous cell carcinoma: + $ref: + - "_terms_enum.yaml#/combined_small_cellsquamous_cell_carcinoma/common" + Combined/mixed carcinoid and adenocarcinoma: + $ref: + - "_terms_enum.yaml#/combinedmixed_carcinoid_and_adenocarcinoma/common" + Comedocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/comedocarcinoma_nos/common" + Common ALL: + $ref: + - "_terms_enum.yaml#/common_all/common" + Common precursor B ALL: + $ref: + - "_terms_enum.yaml#/common_precursor_b_all/common" + Complete hydatidiform mole: + $ref: + - "_terms_enum.yaml#/complete_hydatidiform_mole/common" + Complex odontoma: + $ref: + - "_terms_enum.yaml#/complex_odontoma/common" + Composite carcinoid: + $ref: + - "_terms_enum.yaml#/composite_carcinoid/common" + Compound nevus: + $ref: + - "_terms_enum.yaml#/compound_nevus/common" + Compound odontoma: + $ref: + - "_terms_enum.yaml#/compound_odontoma/common" + Condylomatous carcinoma: + $ref: + - "_terms_enum.yaml#/condylomatous_carcinoma/common" + Congenital fibrosarcoma: + $ref: + - "_terms_enum.yaml#/congenital_fibrosarcoma/common" + Conventional central osteosarcoma: + $ref: + - "_terms_enum.yaml#/conventional_central_osteosarcoma/common" + Cortical T ALL: + $ref: + - "_terms_enum.yaml#/cortical_t_all/common" + CPNET: + $ref: + - "_terms_enum.yaml#/cpnet/common" + Craniopharyngioma: + $ref: + - "_terms_enum.yaml#/craniopharyngioma/common" + Craniopharyngioma, adamantinomatous: + $ref: + - "_terms_enum.yaml#/craniopharyngioma_adamantinomatous/common" + Craniopharyngioma, papillary: + $ref: + - "_terms_enum.yaml#/craniopharyngioma_papillary/common" + Cribriform carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/cribriform_carcinoma_nos/common" + Cutaneous histiocytoma, NOS: + $ref: + - "_terms_enum.yaml#/cutaneous_histiocytoma_nos/common" + Cutaneous lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/cutaneous_lymphoma_nos/common" + Cutaneous mastocytosis: + $ref: + - "_terms_enum.yaml#/cutaneous_mastocytosis/common" + Cutaneous T-cell lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/cutaneous_tcell_lymphoma_nos/common" + Cylindrical cell carcinoma: + $ref: + - "_terms_enum.yaml#/cylindrical_cell_carcinoma/common" + Cylindroma of skin: + $ref: + - "_terms_enum.yaml#/cylindroma_of_skin/common" + Cylindroma, NOS: + $ref: + - "_terms_enum.yaml#/cylindroma_nos/common" + Cystadenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/cystadenocarcinoma_nos/common" + Cystadenofibroma, NOS: + $ref: + - "_terms_enum.yaml#/cystadenofibroma_nos/common" + Cystadenoma, NOS: + $ref: + - "_terms_enum.yaml#/cystadenoma_nos/common" + Cystic astrocytoma: + $ref: + - "_terms_enum.yaml#/cystic_astrocytoma/common" + Cystic hygroma: + $ref: + - "_terms_enum.yaml#/cystic_hygroma/common" + Cystic lymphangioma: + $ref: + - "_terms_enum.yaml#/cystic_lymphangioma/common" + Cystic mesothelioma, NOS: + $ref: + - "_terms_enum.yaml#/cystic_mesothelioma_nos/common" + Cystic partially differentiated nephroblastoma: + $ref: + - "_terms_enum.yaml#/cystic_partially_differentiated_nephroblastoma/common" + Cystic teratoma, NOS: + $ref: + - "_terms_enum.yaml#/cystic_teratoma_nos/common" + Cystic tumor of atrio-ventricular node: + $ref: + - "_terms_enum.yaml#/cystic_tumor_of_atrioventricular_node/common" + Cystoma, NOS: + $ref: + - "_terms_enum.yaml#/cystoma_nos/common" + Cystosarcoma phyllodes, benign: + $ref: + - "_terms_enum.yaml#/cystosarcoma_phyllodes_benign/common" + Cystosarcoma phyllodes, malignant: + $ref: + - "_terms_enum.yaml#/cystosarcoma_phyllodes_malignant/common" + Cystosarcoma phyllodes, NOS: + $ref: + - "_terms_enum.yaml#/cystosarcoma_phyllodes_nos/common" + Dabska tumor: + $ref: + - "_terms_enum.yaml#/dabska_tumor/common" + DCIS, NOS: + $ref: + - "_terms_enum.yaml#/dcis_nos/common" + DCIS, papillary: + $ref: + - "_terms_enum.yaml#/dcis_papillary/common" + Dedifferentiated chondrosarcoma: + $ref: + - "_terms_enum.yaml#/dedifferentiated_chondrosarcoma/common" + Dedifferentiated chordoma: + $ref: + - "_terms_enum.yaml#/dedifferentiated_chordoma/common" + Dedifferentiated liposarcoma: + $ref: + - "_terms_enum.yaml#/dedifferentiated_liposarcoma/common" + Deep histiocytoma: + $ref: + - "_terms_enum.yaml#/deep_histiocytoma/common" + Degenerated schwannoma: + $ref: + - "_terms_enum.yaml#/degenerated_schwannoma/common" + Dendritic cell sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/dendritic_cell_sarcoma_nos/common" + Dentinoma: + $ref: + - "_terms_enum.yaml#/dentinoma/common" + Dermal and epidermal nevus: + $ref: + - "_terms_enum.yaml#/dermal_and_epidermal_nevus/common" + Dermal nevus: + $ref: + - "_terms_enum.yaml#/dermal_nevus/common" + Dermatofibroma lenticulare: + $ref: + - "_terms_enum.yaml#/dermatofibroma_lenticulare/common" + Dermatofibroma, NOS: + $ref: + - "_terms_enum.yaml#/dermatofibroma_nos/common" + Dermatofibrosarcoma protuberans, NOS: + $ref: + - "_terms_enum.yaml#/dermatofibrosarcoma_protuberans_nos/common" + Dermatofibrosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/dermatofibrosarcoma_nos/common" + Dermoid cyst with malignant transformation: + $ref: + - "_terms_enum.yaml#/dermoid_cyst_with_malignant_transformation/common" + Dermoid cyst with secondary tumor: + $ref: + - "_terms_enum.yaml#/dermoid_cyst_with_secondary_tumor/common" + Dermoid cyst, NOS: + $ref: + - "_terms_enum.yaml#/dermoid_cyst_nos/common" + Dermoid, NOS: + $ref: + - "_terms_enum.yaml#/dermoid_nos/common" + Desmoid, NOS: + $ref: + - "_terms_enum.yaml#/desmoid_nos/common" + Desmoplastic fibroma: + $ref: + - "_terms_enum.yaml#/desmoplastic_fibroma/common" + Desmoplastic infantile astrocytoma: + $ref: + - "_terms_enum.yaml#/desmoplastic_infantile_astrocytoma/common" + Desmoplastic infantile ganglioglioma: + $ref: + - "_terms_enum.yaml#/desmoplastic_infantile_ganglioglioma/common" + Desmoplastic medulloblastoma: + $ref: + - "_terms_enum.yaml#/desmoplastic_medulloblastoma/common" + Desmoplastic melanoma, amelanotic: + $ref: + - "_terms_enum.yaml#/desmoplastic_melanoma_amelanotic/common" + Desmoplastic melanoma, malignant: + $ref: + - "_terms_enum.yaml#/desmoplastic_melanoma_malignant/common" + Desmoplastic mesothelioma: + $ref: + - "_terms_enum.yaml#/desmoplastic_mesothelioma/common" + Desmoplastic nodular medulloblastoma: + $ref: + - "_terms_enum.yaml#/desmoplastic_nodular_medulloblastoma/common" + Desmoplastic small round cell tumor: + $ref: + - "_terms_enum.yaml#/desmoplastic_small_round_cell_tumor/common" + Di Guglielmo disease: + $ref: + - "_terms_enum.yaml#/di_guglielmo_disease/common" + Differentiated-type vulvar intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/differentiatedtype_vulvar_intraepithelial_neoplasia/common" + Diffuse astrocytoma: + $ref: + - "_terms_enum.yaml#/diffuse_astrocytoma/common" + Diffuse astrocytoma, IDH-mutant: + $ref: + - "_terms_enum.yaml#/diffuse_astrocytoma_idhmutant/common" + Diffuse astrocytoma, IDH-wildtype: + $ref: + - "_terms_enum.yaml#/diffuse_astrocytoma_idhwildtype/common" + Diffuse astrocytoma, low grade: + $ref: + - "_terms_enum.yaml#/diffuse_astrocytoma_low_grade/common" + Diffuse cutaneous mastocytosis: + $ref: + - "_terms_enum.yaml#/diffuse_cutaneous_mastocytosis/common" + Diffuse intraductal papillomatosis: + $ref: + - "_terms_enum.yaml#/diffuse_intraductal_papillomatosis/common" + Diffuse large B-cell lymphoma associated with chronic inflammation: + $ref: + - "_terms_enum.yaml#/diffuse_large_bcell_lymphoma_associated_with_chronic_inflammation/common" + Diffuse large B-cell lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/diffuse_large_bcell_lymphoma_nos/common" + Diffuse leptomeningeal glioneuronal tumor: + $ref: + - "_terms_enum.yaml#/diffuse_leptomeningeal_glioneuronal_tumor/common" + Diffuse melanocytosis: + $ref: + - "_terms_enum.yaml#/diffuse_melanocytosis/common" + Diffuse meningiomatosis: + $ref: + - "_terms_enum.yaml#/diffuse_meningiomatosis/common" + Diffuse midline glioma, H3 K27M-mutant: + $ref: + - "_terms_enum.yaml#/diffuse_midline_glioma_h3_k27mmutant/common" + Digital papillary adenocarcinoma: + $ref: + - "_terms_enum.yaml#/digital_papillary_adenocarcinoma/common" + Diktyoma, malignant: + $ref: + - "_terms_enum.yaml#/diktyoma_malignant/common" + DIN 3: + $ref: + - "_terms_enum.yaml#/din_3/common" + Duct adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/duct_adenocarcinoma_nos/common" + Duct adenoma, NOS: + $ref: + - "_terms_enum.yaml#/duct_adenoma_nos/common" + Duct carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/duct_carcinoma_nos/common" + Duct cell carcinoma: + $ref: + - "_terms_enum.yaml#/duct_cell_carcinoma/common" + Ductal carcinoma in situ, cribriform type: + $ref: + - "_terms_enum.yaml#/ductal_carcinoma_in_situ_cribriform_type/common" + Ductal carcinoma in situ, NOS: + $ref: + - "_terms_enum.yaml#/ductal_carcinoma_in_situ_nos/common" + Ductal carcinoma in situ, papillary: + $ref: + - "_terms_enum.yaml#/ductal_carcinoma_in_situ_papillary/common" + Ductal carcinoma, cribriform type: + $ref: + - "_terms_enum.yaml#/ductal_carcinoma_cribriform_type/common" + Ductal carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/ductal_carcinoma_nos/common" + Ductal intraepithelial neoplasia 3: + $ref: + - "_terms_enum.yaml#/ductal_intraepithelial_neoplasia_3/common" + Ductal papilloma: + $ref: + - "_terms_enum.yaml#/ductal_papilloma/common" + Dysembryoplastic neuroepithelial tumor: + $ref: + - "_terms_enum.yaml#/dysembryoplastic_neuroepithelial_tumor/common" + Dysgerminoma: + $ref: + - "_terms_enum.yaml#/dysgerminoma/common" + Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos): + $ref: + - "_terms_enum.yaml#/dysplastic_gangliocytoma_of_cerebellum_lhermitteduclos/common" + Dysplastic nevus: + $ref: + - "_terms_enum.yaml#/dysplastic_nevus/common" + EBV positive diffuse large B-cell lymphoma of the elderly: + $ref: + - "_terms_enum.yaml#/ebv_positive_diffuse_large_bcell_lymphoma_of_the_elderly/common" + Ecchondroma: + $ref: + - "_terms_enum.yaml#/ecchondroma/common" + Ecchondrosis: + $ref: + - "_terms_enum.yaml#/ecchondrosis/common" + Eccrine acrospiroma: + $ref: + - "_terms_enum.yaml#/eccrine_acrospiroma/common" + Eccrine cystadenoma: + $ref: + - "_terms_enum.yaml#/eccrine_cystadenoma/common" + Eccrine dermal cylindroma: + $ref: + - "_terms_enum.yaml#/eccrine_dermal_cylindroma/common" + Eccrine papillary adenocarcinoma: + $ref: + - "_terms_enum.yaml#/eccrine_papillary_adenocarcinoma/common" + Eccrine papillary adenoma: + $ref: + - "_terms_enum.yaml#/eccrine_papillary_adenoma/common" + Eccrine poroma: + $ref: + - "_terms_enum.yaml#/eccrine_poroma/common" + Eccrine poroma, malignant: + $ref: + - "_terms_enum.yaml#/eccrine_poroma_malignant/common" + Eccrine spiradenoma: + $ref: + - "_terms_enum.yaml#/eccrine_spiradenoma/common" + ECL cell carcinoid, malignant: + $ref: + - "_terms_enum.yaml#/ecl_cell_carcinoid_malignant/common" + ECL cell carcinoid, NOS: + $ref: + - "_terms_enum.yaml#/ecl_cell_carcinoid_nos/common" + Ectomesenchymoma: + $ref: + - "_terms_enum.yaml#/ectomesenchymoma/common" + Ectopic hamartomatous thymoma: + $ref: + - "_terms_enum.yaml#/ectopic_hamartomatous_thymoma/common" + Elastofibroma: + $ref: + - "_terms_enum.yaml#/elastofibroma/common" + Embryonal adenocarcinoma: + $ref: + - "_terms_enum.yaml#/embryonal_adenocarcinoma/common" + Embryonal carcinoma, infantile: + $ref: + - "_terms_enum.yaml#/embryonal_carcinoma_infantile/common" + Embryonal carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/embryonal_carcinoma_nos/common" + Embryonal hepatoma: + $ref: + - "_terms_enum.yaml#/embryonal_hepatoma/common" + Embryonal rhabdomyosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/embryonal_rhabdomyosarcoma_nos/common" + Embryonal sarcoma: + $ref: + - "_terms_enum.yaml#/embryonal_sarcoma/common" + Embryonal teratoma: + $ref: + - "_terms_enum.yaml#/embryonal_teratoma/common" + Embryonal tumor with multilayered rosettes C19MC-altered: + $ref: + - "_terms_enum.yaml#/embryonal_tumor_with_multilayered_rosettes_c19mcaltered/common" + Embryonal tumor with multilayered rosettes, NOS: + $ref: + - "_terms_enum.yaml#/embryonal_tumor_with_multilayered_rosettes_nos/common" + Embryonal tumor with rhabdoid features: + $ref: + - "_terms_enum.yaml#/embryonal_tumor_with_rhabdoid_features/common" + Encapsulated papillary carcinoma: + $ref: + - "_terms_enum.yaml#/encapsulated_papillary_carcinoma/common" + Encapsulated papillary carcinoma with invasion: + $ref: + - "_terms_enum.yaml#/encapsulated_papillary_carcinoma_with_invasion/common" + Enchondroma: + $ref: + - "_terms_enum.yaml#/enchondroma/common" + Endocervical adenocarcinoma usual type: + $ref: + - "_terms_enum.yaml#/endocervical_adenocarcinoma_usual_type/common" + Endocrine adenomatosis: + $ref: + - "_terms_enum.yaml#/endocrine_adenomatosis/common" + Endocrine tumor, functioning, NOS: + $ref: + - "_terms_enum.yaml#/endocrine_tumor_functioning_nos/common" + Endodermal sinus tumor: + $ref: + - "_terms_enum.yaml#/endodermal_sinus_tumor/common" + Endolymphatic stromal myosis: + $ref: + - "_terms_enum.yaml#/endolymphatic_stromal_myosis/common" + Endometrial sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/endometrial_sarcoma_nos/common" + Endometrial stromal nodule: + $ref: + - "_terms_enum.yaml#/endometrial_stromal_nodule/common" + Endometrial stromal sarcoma, high grade: + $ref: + - "_terms_enum.yaml#/endometrial_stromal_sarcoma_high_grade/common" + Endometrial stromal sarcoma, low grade: + $ref: + - "_terms_enum.yaml#/endometrial_stromal_sarcoma_low_grade/common" + Endometrial stromal sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/endometrial_stromal_sarcoma_nos/common" + Endometrial stromatosis: + $ref: + - "_terms_enum.yaml#/endometrial_stromatosis/common" + Endometrioid adenocarcinoma, ciliated cell variant: + $ref: + - "_terms_enum.yaml#/endometrioid_adenocarcinoma_ciliated_cell_variant/common" + Endometrioid adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/endometrioid_adenocarcinoma_nos/common" + Endometrioid adenocarcinoma, secretory variant: + $ref: + - "_terms_enum.yaml#/endometrioid_adenocarcinoma_secretory_variant/common" + Endometrioid adenocarcinoma, villoglandular: + $ref: + - "_terms_enum.yaml#/endometrioid_adenocarcinoma_villoglandular/common" + Endometrioid adenofibroma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/endometrioid_adenofibroma_borderline_malignancy/common" + Endometrioid adenofibroma, NOS: + $ref: + - "_terms_enum.yaml#/endometrioid_adenofibroma_nos/common" + Endometrioid adenoma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/endometrioid_adenoma_borderline_malignancy/common" + Endometrioid carcinoma with squamous differentiation: + $ref: + - "_terms_enum.yaml#/endometrioid_carcinoma_with_squamous_differentiation/common" + Endometrioid carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/endometrioid_carcinoma_nos/common" + Endometrioid cystadenocarcinoma: + $ref: + - "_terms_enum.yaml#/endometrioid_cystadenocarcinoma/common" + Endometrioid cystadenofibroma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/endometrioid_cystadenofibroma_borderline_malignancy/common" + Endometrioid cystadenofibroma, NOS: + $ref: + - "_terms_enum.yaml#/endometrioid_cystadenofibroma_nos/common" + Endometrioid cystadenoma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/endometrioid_cystadenoma_borderline_malignancy/common" + Endometrioid tumor of low malignant potential: + $ref: + - "_terms_enum.yaml#/endometrioid_tumor_of_low_malignant_potential/common" + Endotheliomatous meningioma: + $ref: + - "_terms_enum.yaml#/endotheliomatous_meningioma/common" + Endovascular papillary angioendothelioma: + $ref: + - "_terms_enum.yaml#/endovascular_papillary_angioendothelioma/common" + Enterochromaffin-like cell carcinoid, NOS: + $ref: + - "_terms_enum.yaml#/enterochromaffinlike_cell_carcinoid_nos/common" + Enterochromaffin-like cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/enterochromaffinlike_cell_tumor_malignant/common" + Enteroglucagonoma, malignant: + $ref: + - "_terms_enum.yaml#/enteroglucagonoma_malignant/common" + Enteroglucagonoma, NOS: + $ref: + - "_terms_enum.yaml#/enteroglucagonoma_nos/common" + Enteropathy associated T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/enteropathy_associated_tcell_lymphoma/common" + Enteropathy type intestinal T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/enteropathy_type_intestinal_tcell_lymphoma/common" + Eosinophil adenocarcinoma: + $ref: + - "_terms_enum.yaml#/eosinophil_adenocarcinoma/common" + Eosinophil adenoma: + $ref: + - "_terms_enum.yaml#/eosinophil_adenoma/common" + Eosinophil carcinoma: + $ref: + - "_terms_enum.yaml#/eosinophil_carcinoma/common" + Eosinophilic granuloma: + $ref: + - "_terms_enum.yaml#/eosinophilic_granuloma/common" + Eosinophilic leukemia: + $ref: + - "_terms_enum.yaml#/eosinophilic_leukemia/common" + Ependymoblastoma: + $ref: + - "_terms_enum.yaml#/ependymoblastoma/common" + Ependymoma, anaplastic: + $ref: + - "_terms_enum.yaml#/ependymoma_anaplastic/common" + Ependymoma, NOS: + $ref: + - "_terms_enum.yaml#/ependymoma_nos/common" + Ependymoma, RELA fusion-positive: + $ref: + - "_terms_enum.yaml#/ependymoma_rela_fusionpositive/common" + Epidermoid carcinoma in situ with questionable stromal invasion: + $ref: + - "_terms_enum.yaml#/epidermoid_carcinoma_in_situ_with_questionable_stromal_invasion/common" + Epidermoid carcinoma in situ, NOS: + $ref: + - "_terms_enum.yaml#/epidermoid_carcinoma_in_situ_nos/common" + Epidermoid carcinoma, keratinizing: + $ref: + - "_terms_enum.yaml#/epidermoid_carcinoma_keratinizing/common" + Epidermoid carcinoma, large cell, nonkeratinizing: + $ref: + - "_terms_enum.yaml#/epidermoid_carcinoma_large_cell_nonkeratinizing/common" + Epidermoid carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/epidermoid_carcinoma_nos/common" + Epidermoid carcinoma, small cell, nonkeratinizing: + $ref: + - "_terms_enum.yaml#/epidermoid_carcinoma_small_cell_nonkeratinizing/common" + Epidermoid carcinoma, spindle cell: + $ref: + - "_terms_enum.yaml#/epidermoid_carcinoma_spindle_cell/common" + Epithelial ependymoma: + $ref: + - "_terms_enum.yaml#/epithelial_ependymoma/common" + Epithelial tumor, benign: + $ref: + - "_terms_enum.yaml#/epithelial_tumor_benign/common" + Epithelial tumor, malignant: + $ref: + - "_terms_enum.yaml#/epithelial_tumor_malignant/common" + Epithelial-myoepithelial carcinoma: + $ref: + - "_terms_enum.yaml#/epithelialmyoepithelial_carcinoma/common" + Epithelioid and spindle cell nevus: + $ref: + - "_terms_enum.yaml#/epithelioid_and_spindle_cell_nevus/common" + Epithelioid cell melanoma: + $ref: + - "_terms_enum.yaml#/epithelioid_cell_melanoma/common" + Epithelioid cell nevus: + $ref: + - "_terms_enum.yaml#/epithelioid_cell_nevus/common" + Epithelioid cell sarcoma: + $ref: + - "_terms_enum.yaml#/epithelioid_cell_sarcoma/common" + Epithelioid glioblastoma: + $ref: + - "_terms_enum.yaml#/epithelioid_glioblastoma/common" + Epithelioid hemangioendothelioma, NOS: + $ref: + - "_terms_enum.yaml#/epithelioid_hemangioendothelioma_nos/common" + Epithelioid hemangioma: + $ref: + - "_terms_enum.yaml#/epithelioid_hemangioma/common" + Epithelioid leiomyoma: + $ref: + - "_terms_enum.yaml#/epithelioid_leiomyoma/common" + Epithelioid leiomyosarcoma: + $ref: + - "_terms_enum.yaml#/epithelioid_leiomyosarcoma/common" + Epithelioid malignant peripheral nerve sheath tumor: + $ref: + - "_terms_enum.yaml#/epithelioid_malignant_peripheral_nerve_sheath_tumor/common" + Epithelioid mesothelioma, benign: + $ref: + - "_terms_enum.yaml#/epithelioid_mesothelioma_benign/common" + Epithelioid mesothelioma, malignant: + $ref: + - "_terms_enum.yaml#/epithelioid_mesothelioma_malignant/common" + Epithelioid mesothelioma, NOS: + $ref: + - "_terms_enum.yaml#/epithelioid_mesothelioma_nos/common" + Epithelioid MPNST: + $ref: + - "_terms_enum.yaml#/epithelioid_mpnst/common" + Epithelioid sarcoma: + $ref: + - "_terms_enum.yaml#/epithelioid_sarcoma/common" + Epithelioma adenoides cysticum: + $ref: + - "_terms_enum.yaml#/epithelioma_adenoides_cysticum/common" + Epithelioma, benign: + $ref: + - "_terms_enum.yaml#/epithelioma_benign/common" + Epithelioma, NOS: + $ref: + - "_terms_enum.yaml#/epithelioma_nos/common" + Erythremic myelosis, NOS: + $ref: + - "_terms_enum.yaml#/erythremic_myelosis_nos/common" + Erythroleukemia: + $ref: + - "_terms_enum.yaml#/erythroleukemia/common" + Esophageal glandular dysplasia (intraepithelial neoplasia), high grade: + $ref: + - "_terms_enum.yaml#/esophageal_glandular_dysplasia_intraepithelial_neoplasia_high_grade/common" + Esophageal glandular dysplasia (intraepithelial neoplasia), low grade: + $ref: + - "_terms_enum.yaml#/esophageal_glandular_dysplasia_intraepithelial_neoplasia_low_grade/common" + Esophageal intraepithelial neoplasia, high grade: + $ref: + - "_terms_enum.yaml#/esophageal_intraepithelial_neoplasia_high_grade/common" + Esophageal squamous intraepithelial neoplasia (dysplasia), high grade: + $ref: + - "_terms_enum.yaml#/esophageal_squamous_intraepithelial_neoplasia_dysplasia_high_grade/common" + Esophageal squamous intraepithelial neoplasia (dysplasia), low grade: + $ref: + - "_terms_enum.yaml#/esophageal_squamous_intraepithelial_neoplasia_dysplasia_low_grade/common" + Essential hemorrhagic thrombocythaemia: + $ref: + - "_terms_enum.yaml#/essential_hemorrhagic_thrombocythaemia/common" + Essential thrombocythemia: + $ref: + - "_terms_enum.yaml#/essential_thrombocythemia/common" + Esthesioneuroblastoma: + $ref: + - "_terms_enum.yaml#/esthesioneuroblastoma/common" + Esthesioneuroepithelioma: + $ref: + - "_terms_enum.yaml#/esthesioneuroepithelioma/common" + Ewing sarcoma: + $ref: + - "_terms_enum.yaml#/ewing_sarcoma/common" + Ewing tumor: + $ref: + - "_terms_enum.yaml#/ewing_tumor/common" + Extra-abdominal desmoid: + $ref: + - "_terms_enum.yaml#/extraabdominal_desmoid/common" + Extra-adrenal paraganglioma, malignant: + $ref: + - "_terms_enum.yaml#/extraadrenal_paraganglioma_malignant/common" + Extra-adrenal paraganglioma, NOS: + $ref: + - "_terms_enum.yaml#/extraadrenal_paraganglioma_nos/common" + Extracutaneous mastocytoma: + $ref: + - "_terms_enum.yaml#/extracutaneous_mastocytoma/common" + Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: + $ref: + - "_terms_enum.yaml#/extranodal_marginal_zone_lymphoma_of_mucosaassociated_lymphoid_tissue/common" + Extranodal NK/T-cell lymphoma, nasal type: + $ref: + - "_terms_enum.yaml#/extranodal_nktcell_lymphoma_nasal_type/common" + Extraosseous plasmacytoma: + $ref: + - "_terms_enum.yaml#/extraosseous_plasmacytoma/common" + Extraventricular neurocytoma: + $ref: + - "_terms_enum.yaml#/extraventricular_neurocytoma/common" + FAB L2: + $ref: + - "_terms_enum.yaml#/fab_l2/common" + FAB L3: + $ref: + - "_terms_enum.yaml#/fab_l3/common" + FAB Ll: + $ref: + - "_terms_enum.yaml#/fab_ll/common" + FAB M1: + $ref: + - "_terms_enum.yaml#/fab_m1/common" + FAB M2, AML1(CBF-alpha)/ETO: + $ref: + - "_terms_enum.yaml#/fab_m2_aml1cbfalphaeto/common" + FAB M2, NOS: + $ref: + - "_terms_enum.yaml#/fab_m2_nos/common" + FAB M2, t(8;21)(q22;q22): + $ref: + - "_terms_enum.yaml#/fab_m2_t821q22q22/common" + FAB M3 (includes all variants): + $ref: + - "_terms_enum.yaml#/fab_m3_includes_all_variants/common" + FAB M4: + $ref: + - "_terms_enum.yaml#/fab_m4/common" + FAB M4Eo: + $ref: + - "_terms_enum.yaml#/fab_m4eo/common" + FAB M5 (includes all variants): + $ref: + - "_terms_enum.yaml#/fab_m5_includes_all_variants/common" + FAB M6: + $ref: + - "_terms_enum.yaml#/fab_m6/common" + FAB M7: + $ref: + - "_terms_enum.yaml#/fab_m7/common" + FAB MO: + $ref: + - "_terms_enum.yaml#/fab_mo/common" + Familial polyposis coli: + $ref: + - "_terms_enum.yaml#/familial_polyposis_coli/common" + Fascial fibroma: + $ref: + - "_terms_enum.yaml#/fascial_fibroma/common" + Fascial fibrosarcoma: + $ref: + - "_terms_enum.yaml#/fascial_fibrosarcoma/common" + Fetal adenocarcinoma: + $ref: + - "_terms_enum.yaml#/fetal_adenocarcinoma/common" + Fetal adenoma: + $ref: + - "_terms_enum.yaml#/fetal_adenoma/common" + Fetal fat cell lipoma: + $ref: + - "_terms_enum.yaml#/fetal_fat_cell_lipoma/common" + Fetal lipoma, NOS: + $ref: + - "_terms_enum.yaml#/fetal_lipoma_nos/common" + Fetal lipomatosis: + $ref: + - "_terms_enum.yaml#/fetal_lipomatosis/common" + Fetal rhabdomyoma: + $ref: + - "_terms_enum.yaml#/fetal_rhabdomyoma/common" + Fibrillary astrocytoma: + $ref: + - "_terms_enum.yaml#/fibrillary_astrocytoma/common" + Fibro-osteoma: + $ref: + - "_terms_enum.yaml#/fibroosteoma/common" + Fibroadenoma, NOS: + $ref: + - "_terms_enum.yaml#/fibroadenoma_nos/common" + Fibroameloblastic odontoma: + $ref: + - "_terms_enum.yaml#/fibroameloblastic_odontoma/common" + Fibroblastic liposarcoma: + $ref: + - "_terms_enum.yaml#/fibroblastic_liposarcoma/common" + Fibroblastic meningioma: + $ref: + - "_terms_enum.yaml#/fibroblastic_meningioma/common" + Fibroblastic osteosarcoma: + $ref: + - "_terms_enum.yaml#/fibroblastic_osteosarcoma/common" + Fibroblastic reticular cell tumor: + $ref: + - "_terms_enum.yaml#/fibroblastic_reticular_cell_tumor/common" + Fibrochondrosarcoma: + $ref: + - "_terms_enum.yaml#/fibrochondrosarcoma/common" + Fibroepithelial basal cell carcinoma, Pinkus type: + $ref: + - "_terms_enum.yaml#/fibroepithelial_basal_cell_carcinoma_pinkus_type/common" + Fibroepithelioma of Pinkus type: + $ref: + - "_terms_enum.yaml#/fibroepithelioma_of_pinkus_type/common" + Fibroepithelioma, NOS: + $ref: + - "_terms_enum.yaml#/fibroepithelioma_nos/common" + Fibrofolliculoma: + $ref: + - "_terms_enum.yaml#/fibrofolliculoma/common" + Fibroid uterus: + $ref: + - "_terms_enum.yaml#/fibroid_uterus/common" + Fibrolipoma: + $ref: + - "_terms_enum.yaml#/fibrolipoma/common" + Fibroliposarcoma: + $ref: + - "_terms_enum.yaml#/fibroliposarcoma/common" + Fibroma, NOS: + $ref: + - "_terms_enum.yaml#/fibroma_nos/common" + Fibromyoma: + $ref: + - "_terms_enum.yaml#/fibromyoma/common" + Fibromyxolipoma: + $ref: + - "_terms_enum.yaml#/fibromyxolipoma/common" + Fibromyxoma: + $ref: + - "_terms_enum.yaml#/fibromyxoma/common" + Fibromyxosarcoma: + $ref: + - "_terms_enum.yaml#/fibromyxosarcoma/common" + Fibrosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/fibrosarcoma_nos/common" + Fibrosarcomatous dermatofibrosarcoma protuberans: + $ref: + - "_terms_enum.yaml#/fibrosarcomatous_dermatofibrosarcoma_protuberans/common" + Fibrous astrocytoma: + $ref: + - "_terms_enum.yaml#/fibrous_astrocytoma/common" + Fibrous histiocytoma of tendon sheath: + $ref: + - "_terms_enum.yaml#/fibrous_histiocytoma_of_tendon_sheath/common" + Fibrous histiocytoma, NOS: + $ref: + - "_terms_enum.yaml#/fibrous_histiocytoma_nos/common" + Fibrous meningioma: + $ref: + - "_terms_enum.yaml#/fibrous_meningioma/common" + Fibrous mesothelioma, benign: + $ref: + - "_terms_enum.yaml#/fibrous_mesothelioma_benign/common" + Fibrous mesothelioma, malignant: + $ref: + - "_terms_enum.yaml#/fibrous_mesothelioma_malignant/common" + Fibrous mesothelioma, NOS: + $ref: + - "_terms_enum.yaml#/fibrous_mesothelioma_nos/common" + Fibroxanthoma, malignant: + $ref: + - "_terms_enum.yaml#/fibroxanthoma_malignant/common" + Fibroxanthoma, NOS: + $ref: + - "_terms_enum.yaml#/fibroxanthoma_nos/common" + Flat adenoma: + $ref: + - "_terms_enum.yaml#/flat_adenoma/common" + Florid osseous dysplasia: + $ref: + - "_terms_enum.yaml#/florid_osseous_dysplasia/common" + Follicular adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/follicular_adenocarcinoma_nos/common" + Follicular adenocarcinoma, well differentiated: + $ref: + - "_terms_enum.yaml#/follicular_adenocarcinoma_well_differentiated/common" + Follicular adenoma: + $ref: + - "_terms_enum.yaml#/follicular_adenoma/common" + Follicular adenoma, oxyphilic cell: + $ref: + - "_terms_enum.yaml#/follicular_adenoma_oxyphilic_cell/common" + Follicular carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/follicular_carcinoma_nos/common" + Follicular carcinoma, oxyphilic cell: + $ref: + - "_terms_enum.yaml#/follicular_carcinoma_oxyphilic_cell/common" + Follicular carcinoma, well differentiated: + $ref: + - "_terms_enum.yaml#/follicular_carcinoma_well_differentiated/common" + Follicular dendritic cell sarcoma: + $ref: + - "_terms_enum.yaml#/follicular_dendritic_cell_sarcoma/common" + Follicular dendritic cell tumor: + $ref: + - "_terms_enum.yaml#/follicular_dendritic_cell_tumor/common" + Follicular fibroma: + $ref: + - "_terms_enum.yaml#/follicular_fibroma/common" + Follicular lymphoma, grade 1: + $ref: + - "_terms_enum.yaml#/follicular_lymphoma_grade_1/common" + Follicular lymphoma, grade 2: + $ref: + - "_terms_enum.yaml#/follicular_lymphoma_grade_2/common" + Follicular lymphoma, grade 3: + $ref: + - "_terms_enum.yaml#/follicular_lymphoma_grade_3/common" + Follicular lymphoma, grade 3A: + $ref: + - "_terms_enum.yaml#/follicular_lymphoma_grade_3a/common" + Follicular lymphoma, grade 3B: + $ref: + - "_terms_enum.yaml#/follicular_lymphoma_grade_3b/common" + Follicular lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/follicular_lymphoma_nos/common" + Follicular lymphoma, small cleaved cell: + $ref: + - "_terms_enum.yaml#/follicular_lymphoma_small_cleaved_cell/common" + Follicular thyroid carcinoma (FTC), encapsulated angioinvasive: + $ref: + - "_terms_enum.yaml#/follicular_thyroid_carcinoma_ftc_encapsulated_angioinvasive/common" + Franklin disease: + $ref: + - "_terms_enum.yaml#/franklin_disease/common" + G cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/g_cell_tumor_malignant/common" + G cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/g_cell_tumor_nos/common" + Gamma heavy chain disease: + $ref: + - "_terms_enum.yaml#/gamma_heavy_chain_disease/common" + Gangliocytic paraganglioma: + $ref: + - "_terms_enum.yaml#/gangliocytic_paraganglioma/common" + Gangliocytoma: + $ref: + - "_terms_enum.yaml#/gangliocytoma/common" + Ganglioglioma, anaplastic: + $ref: + - "_terms_enum.yaml#/ganglioglioma_anaplastic/common" + Ganglioglioma, NOS: + $ref: + - "_terms_enum.yaml#/ganglioglioma_nos/common" + Ganglioneuroblastoma: + $ref: + - "_terms_enum.yaml#/ganglioneuroblastoma/common" + Ganglioneuroma: + $ref: + - "_terms_enum.yaml#/ganglioneuroma/common" + Ganglioneuromatosis: + $ref: + - "_terms_enum.yaml#/ganglioneuromatosis/common" + GANT: + $ref: + - "_terms_enum.yaml#/gant/common" + Gastrin cell tumor: + $ref: + - "_terms_enum.yaml#/gastrin_cell_tumor/common" + Gastrin cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/gastrin_cell_tumor_malignant/common" + Gastrinoma, malignant: + $ref: + - "_terms_enum.yaml#/gastrinoma_malignant/common" + Gastrinoma, NOS: + $ref: + - "_terms_enum.yaml#/gastrinoma_nos/common" + Gastrointestinal autonomic nerve tumor: + $ref: + - "_terms_enum.yaml#/gastrointestinal_autonomic_nerve_tumor/common" + Gastrointestinal stromal sarcoma: + $ref: + - "_terms_enum.yaml#/gastrointestinal_stromal_sarcoma/common" + Gastrointestinal stromal tumor, benign: + $ref: + - "_terms_enum.yaml#/gastrointestinal_stromal_tumor_benign/common" + Gastrointestinal stromal tumor, malignant: + $ref: + - "_terms_enum.yaml#/gastrointestinal_stromal_tumor_malignant/common" + Gastrointestinal stromal tumor, NOS: + $ref: + - "_terms_enum.yaml#/gastrointestinal_stromal_tumor_nos/common" + Gastrointestinal stromal tumor, uncertain malignant potential: + $ref: + - "_terms_enum.yaml#/gastrointestinal_stromal_tumor_uncertain_malignant_potential/common" + Gelatinous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/gelatinous_adenocarcinoma/common" + Gelatinous carcinoma: + $ref: + - "_terms_enum.yaml#/gelatinous_carcinoma/common" + Gemistocytic astrocytoma: + $ref: + - "_terms_enum.yaml#/gemistocytic_astrocytoma/common" + Gemistocytoma: + $ref: + - "_terms_enum.yaml#/gemistocytoma/common" + Genital rhabdomyoma: + $ref: + - "_terms_enum.yaml#/genital_rhabdomyoma/common" + Germ cell tumor, nonseminomatous: + $ref: + - "_terms_enum.yaml#/germ_cell_tumor_nonseminomatous/common" + Germ cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/germ_cell_tumor_nos/common" + Germ cell tumors with associated hematological malignancy: + $ref: + - "_terms_enum.yaml#/germ_cell_tumors_with_associated_hematological_malignancy/common" + Germinoma: + $ref: + - "_terms_enum.yaml#/germinoma/common" + Ghost cell odontogenic carcinoma: + $ref: + - "_terms_enum.yaml#/ghost_cell_odontogenic_carcinoma/common" + Giant cell and spindle cell carcinoma: + $ref: + - "_terms_enum.yaml#/giant_cell_and_spindle_cell_carcinoma/common" + Giant cell angiofibroma: + $ref: + - "_terms_enum.yaml#/giant_cell_angiofibroma/common" + Giant cell carcinoma: + $ref: + - "_terms_enum.yaml#/giant_cell_carcinoma/common" + Giant cell fibroblastoma: + $ref: + - "_terms_enum.yaml#/giant_cell_fibroblastoma/common" + Giant cell glioblastoma: + $ref: + - "_terms_enum.yaml#/giant_cell_glioblastoma/common" + Giant cell sarcoma: + $ref: + - "_terms_enum.yaml#/giant_cell_sarcoma/common" + Giant cell sarcoma of bone: + $ref: + - "_terms_enum.yaml#/giant_cell_sarcoma_of_bone/common" + Giant cell tumor of bone, malignant: + $ref: + - "_terms_enum.yaml#/giant_cell_tumor_of_bone_malignant/common" + Giant cell tumor of bone, NOS: + $ref: + - "_terms_enum.yaml#/giant_cell_tumor_of_bone_nos/common" + Giant cell tumor of soft parts, NOS: + $ref: + - "_terms_enum.yaml#/giant_cell_tumor_of_soft_parts_nos/common" + Giant cell tumor of tendon sheath: + $ref: + - "_terms_enum.yaml#/giant_cell_tumor_of_tendon_sheath/common" + Giant cell tumor of tendon sheath, malignant: + $ref: + - "_terms_enum.yaml#/giant_cell_tumor_of_tendon_sheath_malignant/common" + Giant fibroadenoma: + $ref: + - "_terms_enum.yaml#/giant_fibroadenoma/common" + Giant osteoid osteoma: + $ref: + - "_terms_enum.yaml#/giant_osteoid_osteoma/common" + Giant pigmented nevus, NOS: + $ref: + - "_terms_enum.yaml#/giant_pigmented_nevus_nos/common" + Gigantiform cementoma: + $ref: + - "_terms_enum.yaml#/gigantiform_cementoma/common" + GIST, benign: + $ref: + - "_terms_enum.yaml#/gist_benign/common" + GIST, malignant: + $ref: + - "_terms_enum.yaml#/gist_malignant/common" + GIST, NOS: + $ref: + - "_terms_enum.yaml#/gist_nos/common" + Glandular intraepithelial neoplasia, grade I: + $ref: + - "_terms_enum.yaml#/glandular_intraepithelial_neoplasia_grade_i/common" + Glandular intraepithelial neoplasia, grade II: + $ref: + - "_terms_enum.yaml#/glandular_intraepithelial_neoplasia_grade_ii/common" + Glandular intraepithelial neoplasia, grade III: + $ref: + - "_terms_enum.yaml#/glandular_intraepithelial_neoplasia_grade_iii/common" + Glandular intraepithelial neoplasia, high grade: + $ref: + - "_terms_enum.yaml#/glandular_intraepithelial_neoplasia_high_grade/common" + Glandular intraepithelial neoplasia, low grade: + $ref: + - "_terms_enum.yaml#/glandular_intraepithelial_neoplasia_low_grade/common" + Glandular papilloma: + $ref: + - "_terms_enum.yaml#/glandular_papilloma/common" + Glassy cell carcinoma: + $ref: + - "_terms_enum.yaml#/glassy_cell_carcinoma/common" + Glioblastoma: + $ref: + - "_terms_enum.yaml#/glioblastoma/common" + Glioblastoma multiforme: + $ref: + - "_terms_enum.yaml#/glioblastoma_multiforme/common" + Glioblastoma with sarcomatous component: + $ref: + - "_terms_enum.yaml#/glioblastoma_with_sarcomatous_component/common" + Glioblastoma, IDH wildtype: + $ref: + - "_terms_enum.yaml#/glioblastoma_idh_wildtype/common" + Glioblastoma, IDH-mutant: + $ref: + - "_terms_enum.yaml#/glioblastoma_idhmutant/common" + Gliofibroma: + $ref: + - "_terms_enum.yaml#/gliofibroma/common" + Glioma, malignant: + $ref: + - "_terms_enum.yaml#/glioma_malignant/common" + Glioma, NOS: + $ref: + - "_terms_enum.yaml#/glioma_nos/common" + Gliomatosis cerebri: + $ref: + - "_terms_enum.yaml#/gliomatosis_cerebri/common" + Glioneuroma: + $ref: + - "_terms_enum.yaml#/glioneuroma/common" + Gliosarcoma: + $ref: + - "_terms_enum.yaml#/gliosarcoma/common" + Glomangioma: + $ref: + - "_terms_enum.yaml#/glomangioma/common" + Glomangiomyoma: + $ref: + - "_terms_enum.yaml#/glomangiomyoma/common" + Glomangiosarcoma: + $ref: + - "_terms_enum.yaml#/glomangiosarcoma/common" + Glomoid sarcoma: + $ref: + - "_terms_enum.yaml#/glomoid_sarcoma/common" + Glomus jugulare tumor, NOS: + $ref: + - "_terms_enum.yaml#/glomus_jugulare_tumor_nos/common" + Glomus tumor, malignant: + $ref: + - "_terms_enum.yaml#/glomus_tumor_malignant/common" + Glomus tumor, NOS: + $ref: + - "_terms_enum.yaml#/glomus_tumor_nos/common" + Glucagonoma, malignant: + $ref: + - "_terms_enum.yaml#/glucagonoma_malignant/common" + Glycogen-rich carcinoma: + $ref: + - "_terms_enum.yaml#/glycogenrich_carcinoma/common" + Goblet cell carcinoid: + $ref: + - "_terms_enum.yaml#/goblet_cell_carcinoid/common" + Gonadal stromal tumor, NOS: + $ref: + - "_terms_enum.yaml#/gonadal_stromal_tumor_nos/common" + Gonadoblastoma: + $ref: + - "_terms_enum.yaml#/gonadoblastoma/common" + Gonocytoma: + $ref: + - "_terms_enum.yaml#/gonocytoma/common" + Granular cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/granular_cell_adenocarcinoma/common" + Granular cell carcinoma: + $ref: + - "_terms_enum.yaml#/granular_cell_carcinoma/common" + Granular cell myoblastoma, malignant: + $ref: + - "_terms_enum.yaml#/granular_cell_myoblastoma_malignant/common" + Granular cell myoblastoma, NOS: + $ref: + - "_terms_enum.yaml#/granular_cell_myoblastoma_nos/common" + Granular cell tumor of the sellar region: + $ref: + - "_terms_enum.yaml#/granular_cell_tumor_of_the_sellar_region/common" + Granular cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/granular_cell_tumor_malignant/common" + Granular cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/granular_cell_tumor_nos/common" + Granulocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/granulocytic_leukemia_nos/common" + Granulocytic sarcoma: + $ref: + - "_terms_enum.yaml#/granulocytic_sarcoma/common" + Granulosa cell carcinoma: + $ref: + - "_terms_enum.yaml#/granulosa_cell_carcinoma/common" + Granulosa cell tumor, adult type: + $ref: + - "_terms_enum.yaml#/granulosa_cell_tumor_adult_type/common" + Granulosa cell tumor, juvenile: + $ref: + - "_terms_enum.yaml#/granulosa_cell_tumor_juvenile/common" + Granulosa cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/granulosa_cell_tumor_malignant/common" + Granulosa cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/granulosa_cell_tumor_nos/common" + Granulosa cell-theca cell tumor: + $ref: + - "_terms_enum.yaml#/granulosa_celltheca_cell_tumor/common" + Grawitz tumor: + $ref: + - "_terms_enum.yaml#/grawitz_tumor/common" + Gynandroblastoma: + $ref: + - "_terms_enum.yaml#/gynandroblastoma/common" + Haemangioblastoma: + $ref: + - "_terms_enum.yaml#/haemangioblastoma/common" + Haemangiosarcoma: + $ref: + - "_terms_enum.yaml#/haemangiosarcoma/common" + Hairy cell leukemia: + $ref: + - "_terms_enum.yaml#/hairy_cell_leukemia/common" + Hairy cell leukemia variant: + $ref: + - "_terms_enum.yaml#/hairy_cell_leukemia_variant/common" + Hairy nevus: + $ref: + - "_terms_enum.yaml#/hairy_nevus/common" + Halo nevus: + $ref: + - "_terms_enum.yaml#/halo_nevus/common" + Hand-Schuller-Christian disease: + $ref: + - "_terms_enum.yaml#/handschullerchristian_disease/common" + Heavy chain disease, NOS: + $ref: + - "_terms_enum.yaml#/heavy_chain_disease_nos/common" + Hemangioblastic meningioma: + $ref: + - "_terms_enum.yaml#/hemangioblastic_meningioma/common" + Hemangioendothelial sarcoma: + $ref: + - "_terms_enum.yaml#/hemangioendothelial_sarcoma/common" + Hemangioendothelioma, benign: + $ref: + - "_terms_enum.yaml#/hemangioendothelioma_benign/common" + Hemangioendothelioma, malignant: + $ref: + - "_terms_enum.yaml#/hemangioendothelioma_malignant/common" + Hemangioendothelioma, NOS: + $ref: + - "_terms_enum.yaml#/hemangioendothelioma_nos/common" + Hemangioma simplex: + $ref: + - "_terms_enum.yaml#/hemangioma_simplex/common" + Hemangioma, NOS: + $ref: + - "_terms_enum.yaml#/hemangioma_nos/common" + Hemangiopericytoma, benign: + $ref: + - "_terms_enum.yaml#/hemangiopericytoma_benign/common" + Hemangiopericytoma, malignant: + $ref: + - "_terms_enum.yaml#/hemangiopericytoma_malignant/common" + Hemangiopericytoma, NOS: + $ref: + - "_terms_enum.yaml#/hemangiopericytoma_nos/common" + Hemolymphangioma: + $ref: + - "_terms_enum.yaml#/hemolymphangioma/common" + Hepatoblastoma: + $ref: + - "_terms_enum.yaml#/hepatoblastoma/common" + Hepatoblastoma, mixed epithelial-mesenchymal: + $ref: + - "_terms_enum.yaml#/hepatoblastoma_mixed_epithelialmesenchymal/common" + Hepatocarcinoma: + $ref: + - "_terms_enum.yaml#/hepatocarcinoma/common" + Hepatocellular adenoma: + $ref: + - "_terms_enum.yaml#/hepatocellular_adenoma/common" + Hepatocellular carcinoma, fibrolamellar: + $ref: + - "_terms_enum.yaml#/hepatocellular_carcinoma_fibrolamellar/common" + Hepatocellular carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/hepatocellular_carcinoma_nos/common" + Hepatocellular carcinoma, scirrhous: + $ref: + - "_terms_enum.yaml#/hepatocellular_carcinoma_scirrhous/common" + Hepatocholangiocarcinoma: + $ref: + - "_terms_enum.yaml#/hepatocholangiocarcinoma/common" + Hepatoid adenocarcinoma: + $ref: + - "_terms_enum.yaml#/hepatoid_adenocarcinoma/common" + Hepatoid carcinoma: + $ref: + - "_terms_enum.yaml#/hepatoid_carcinoma/common" + Hepatoid yolk sac tumor: + $ref: + - "_terms_enum.yaml#/hepatoid_yolk_sac_tumor/common" + Hepatoma, benign: + $ref: + - "_terms_enum.yaml#/hepatoma_benign/common" + Hepatoma, malignant: + $ref: + - "_terms_enum.yaml#/hepatoma_malignant/common" + Hepatoma, NOS: + $ref: + - "_terms_enum.yaml#/hepatoma_nos/common" + Hepatosplenic gamma-delta cell lymphoma: + $ref: + - "_terms_enum.yaml#/hepatosplenic_gammadelta_cell_lymphoma/common" + Hepatosplenic T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/hepatosplenic_tcell_lymphoma/common" + Hereditary leiomyomatosis & RCC-associated renal cell carcinoma: + $ref: + - "_terms_enum.yaml#/hereditary_leiomyomatosis__rccassociated_renal_cell_carcinoma/common" + Hibernoma: + $ref: + - "_terms_enum.yaml#/hibernoma/common" + Hidradenocarcinoma: + $ref: + - "_terms_enum.yaml#/hidradenocarcinoma/common" + Hidradenoma papilliferum: + $ref: + - "_terms_enum.yaml#/hidradenoma_papilliferum/common" + Hidradenoma, NOS: + $ref: + - "_terms_enum.yaml#/hidradenoma_nos/common" + Hidrocystoma: + $ref: + - "_terms_enum.yaml#/hidrocystoma/common" + High grade surface osteosarcoma: + $ref: + - "_terms_enum.yaml#/high_grade_surface_osteosarcoma/common" + Hilar cell tumor: + $ref: + - "_terms_enum.yaml#/hilar_cell_tumor/common" + Hilus cell tumor: + $ref: + - "_terms_enum.yaml#/hilus_cell_tumor/common" + Histiocyte-rich large B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/histiocyterich_large_bcell_lymphoma/common" + Histiocytic medullary reticulosis: + $ref: + - "_terms_enum.yaml#/histiocytic_medullary_reticulosis/common" + Histiocytic sarcoma: + $ref: + - "_terms_enum.yaml#/histiocytic_sarcoma/common" + Histiocytoid hemangioma: + $ref: + - "_terms_enum.yaml#/histiocytoid_hemangioma/common" + Histiocytoma, NOS: + $ref: + - "_terms_enum.yaml#/histiocytoma_nos/common" + Histiocytosis X, NOS: + $ref: + - "_terms_enum.yaml#/histiocytosis_x_nos/common" + Hodgkin disease, lymphocyte predominance, diffuse: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_lymphocyte_predominance_diffuse/common" + Hodgkin disease, lymphocyte predominance, NOS: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_lymphocyte_predominance_nos/common" + Hodgkin disease, lymphocytic-histiocytic predominance: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_lymphocytichistiocytic_predominance/common" + Hodgkin disease, nodular sclerosis, lymphocyte depletion: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_nodular_sclerosis_lymphocyte_depletion/common" + Hodgkin disease, nodular sclerosis, lymphocyte predominance: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_nodular_sclerosis_lymphocyte_predominance/common" + Hodgkin disease, nodular sclerosis, mixed cellularity: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_nodular_sclerosis_mixed_cellularity/common" + Hodgkin disease, nodular sclerosis, NOS: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_nodular_sclerosis_nos/common" + Hodgkin disease, nodular sclerosis, syncytial variant: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_nodular_sclerosis_syncytial_variant/common" + Hodgkin disease, NOS: + $ref: + - "_terms_enum.yaml#/hodgkin_disease_nos/common" + Hodgkin granuloma: + $ref: + - "_terms_enum.yaml#/hodgkin_granuloma/common" + Hodgkin lymphoma, lymphocyte depletion, NOS: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_lymphocyte_depletion_nos/common" + Hodgkin lymphoma, lymphocyte predominance, nodular: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_lymphocyte_predominance_nodular/common" + Hodgkin lymphoma, lymphocyte-rich: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_lymphocyterich/common" + Hodgkin lymphoma, mixed cellularity, NOS: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_mixed_cellularity_nos/common" + Hodgkin lymphoma, nodular lymphocyte predominance: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_nodular_lymphocyte_predominance/common" + Hodgkin lymphoma, nodular sclerosis, cellular phase: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_nodular_sclerosis_cellular_phase/common" + Hodgkin lymphoma, nodular sclerosis, grade 1: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_nodular_sclerosis_grade_1/common" + Hodgkin lymphoma, nodular sclerosis, grade 2: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_nodular_sclerosis_grade_2/common" + Hodgkin lymphoma, nodular sclerosis, NOS: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_nodular_sclerosis_nos/common" + Hodgkin lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/hodgkin_lymphoma_nos/common" + Hodgkin paragranuloma, nodular: + $ref: + - "_terms_enum.yaml#/hodgkin_paragranuloma_nodular/common" + Hodgkin paragranuloma, NOS: + $ref: + - "_terms_enum.yaml#/hodgkin_paragranuloma_nos/common" + Hodgkin sarcoma: + $ref: + - "_terms_enum.yaml#/hodgkin_sarcoma/common" + Hurthle cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/hurthle_cell_adenocarcinoma/common" + Hurthle cell adenoma: + $ref: + - "_terms_enum.yaml#/hurthle_cell_adenoma/common" + Hurthle cell carcinoma: + $ref: + - "_terms_enum.yaml#/hurthle_cell_carcinoma/common" + Hurthle cell tumor: + $ref: + - "_terms_enum.yaml#/hurthle_cell_tumor/common" + Hutchinson melanotic freckle, NOS: + $ref: + - "_terms_enum.yaml#/hutchinson_melanotic_freckle_nos/common" + Hyalinizing trabecular adenoma: + $ref: + - "_terms_enum.yaml#/hyalinizing_trabecular_adenoma/common" + Hydatid mole: + $ref: + - "_terms_enum.yaml#/hydatid_mole/common" + Hydatidiform mole, NOS: + $ref: + - "_terms_enum.yaml#/hydatidiform_mole_nos/common" + Hydroa vacciniforme-like lymphoma: + $ref: + - "_terms_enum.yaml#/hydroa_vacciniformelike_lymphoma/common" + Hygroma, NOS: + $ref: + - "_terms_enum.yaml#/hygroma_nos/common" + Hypereosinophilic syndrome: + $ref: + - "_terms_enum.yaml#/hypereosinophilic_syndrome/common" + Hypernephroma: + $ref: + - "_terms_enum.yaml#/hypernephroma/common" + Idiopathic hemorrhagic thrombocythaemia: + $ref: + - "_terms_enum.yaml#/idiopathic_hemorrhagic_thrombocythaemia/common" + Idiopathic thrombocythemia: + $ref: + - "_terms_enum.yaml#/idiopathic_thrombocythemia/common" + Immature teratoma, malignant: + $ref: + - "_terms_enum.yaml#/immature_teratoma_malignant/common" + Immature teratoma, NOS: + $ref: + - "_terms_enum.yaml#/immature_teratoma_nos/common" + Immunoblastic sarcoma: + $ref: + - "_terms_enum.yaml#/immunoblastic_sarcoma/common" + Immunocytoma: + $ref: + - "_terms_enum.yaml#/immunocytoma/common" + Immunoglobulin deposition disease: + $ref: + - "_terms_enum.yaml#/immunoglobulin_deposition_disease/common" + Immunoproliferative small intestinal disease: + $ref: + - "_terms_enum.yaml#/immunoproliferative_small_intestinal_disease/common" + Indeterminate dendritic cell tumor: + $ref: + - "_terms_enum.yaml#/indeterminate_dendritic_cell_tumor/common" + Indolent systemic mastocytosis: + $ref: + - "_terms_enum.yaml#/indolent_systemic_mastocytosis/common" + Infantile fibrosarcoma: + $ref: + - "_terms_enum.yaml#/infantile_fibrosarcoma/common" + Infantile hemangioma: + $ref: + - "_terms_enum.yaml#/infantile_hemangioma/common" + Infantile myofibromatosis: + $ref: + - "_terms_enum.yaml#/infantile_myofibromatosis/common" + Infiltrating and papillary adenocarcinoma: + $ref: + - "_terms_enum.yaml#/infiltrating_and_papillary_adenocarcinoma/common" + Infiltrating angiolipoma: + $ref: + - "_terms_enum.yaml#/infiltrating_angiolipoma/common" + Infiltrating basal cell carcinoma, non-sclerosing: + $ref: + - "_terms_enum.yaml#/infiltrating_basal_cell_carcinoma_nonsclerosing/common" + Infiltrating basal cell carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/infiltrating_basal_cell_carcinoma_nos/common" + Infiltrating basal cell carcinoma, sclerosing: + $ref: + - "_terms_enum.yaml#/infiltrating_basal_cell_carcinoma_sclerosing/common" + Infiltrating duct adenocarcinoma: + $ref: + - "_terms_enum.yaml#/infiltrating_duct_adenocarcinoma/common" + Infiltrating duct and lobular carcinoma: + $ref: + - "_terms_enum.yaml#/infiltrating_duct_and_lobular_carcinoma/common" + Infiltrating duct and lobular carcinoma in situ: + $ref: + - "_terms_enum.yaml#/infiltrating_duct_and_lobular_carcinoma_in_situ/common" + Infiltrating duct carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/infiltrating_duct_carcinoma_nos/common" + Infiltrating ductular carcinoma: + $ref: + - "_terms_enum.yaml#/infiltrating_ductular_carcinoma/common" + Infiltrating lipoma: + $ref: + - "_terms_enum.yaml#/infiltrating_lipoma/common" + Infiltrating lobular carcinoma and ductal carcinoma in situ: + $ref: + - "_terms_enum.yaml#/infiltrating_lobular_carcinoma_and_ductal_carcinoma_in_situ/common" + Infiltrating lobular carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/infiltrating_lobular_carcinoma_nos/common" + Infiltrating papillary adenocarcinoma: + $ref: + - "_terms_enum.yaml#/infiltrating_papillary_adenocarcinoma/common" + Inflammatory liposarcoma: + $ref: + - "_terms_enum.yaml#/inflammatory_liposarcoma/common" + Inflammatory myofibroblastic tumor: + $ref: + - "_terms_enum.yaml#/inflammatory_myofibroblastic_tumor/common" + Insular carcinoma: + $ref: + - "_terms_enum.yaml#/insular_carcinoma/common" + Insulinoma, malignant: + $ref: + - "_terms_enum.yaml#/insulinoma_malignant/common" + Insulinoma, NOS: + $ref: + - "_terms_enum.yaml#/insulinoma_nos/common" + Interdigitating cell sarcoma: + $ref: + - "_terms_enum.yaml#/interdigitating_cell_sarcoma/common" + Interdigitating dendritic cell sarcoma: + $ref: + - "_terms_enum.yaml#/interdigitating_dendritic_cell_sarcoma/common" + Interstitial cell tumor, benign: + $ref: + - "_terms_enum.yaml#/interstitial_cell_tumor_benign/common" + Interstitial cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/interstitial_cell_tumor_malignant/common" + Interstitial cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/interstitial_cell_tumor_nos/common" + Intestinal T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/intestinal_tcell_lymphoma/common" + Intestinal-type adenocarcinoma: + $ref: + - "_terms_enum.yaml#/intestinaltype_adenocarcinoma/common" + Intimal sarcoma: + $ref: + - "_terms_enum.yaml#/intimal_sarcoma/common" + Intracanalicular fibroadenoma: + $ref: + - "_terms_enum.yaml#/intracanalicular_fibroadenoma/common" + Intracortical osteosarcoma: + $ref: + - "_terms_enum.yaml#/intracortical_osteosarcoma/common" + Intracystic carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/intracystic_carcinoma_nos/common" + Intracystic papillary adenocarcinoma: + $ref: + - "_terms_enum.yaml#/intracystic_papillary_adenocarcinoma/common" + Intracystic papillary adenoma: + $ref: + - "_terms_enum.yaml#/intracystic_papillary_adenoma/common" + Intracystic papillary neoplasm with intermediate grade intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/intracystic_papillary_neoplasm_with_intermediate_grade_intraepithelial_neoplasia/common" + Intracystic papillary neoplasm with low grade intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/intracystic_papillary_neoplasm_with_low_grade_intraepithelial_neoplasia/common" + Intracystic papilloma: + $ref: + - "_terms_enum.yaml#/intracystic_papilloma/common" + Intradermal nevus: + $ref: + - "_terms_enum.yaml#/intradermal_nevus/common" + Intraductal adenocarcinoma, noninfiltrating, NOS: + $ref: + - "_terms_enum.yaml#/intraductal_adenocarcinoma_noninfiltrating_nos/common" + Intraductal and lobular carcinoma: + $ref: + - "_terms_enum.yaml#/intraductal_and_lobular_carcinoma/common" + Intraductal carcinoma and lobular carcinoma in situ: + $ref: + - "_terms_enum.yaml#/intraductal_carcinoma_and_lobular_carcinoma_in_situ/common" + Intraductal carcinoma, noninfiltrating, NOS: + $ref: + - "_terms_enum.yaml#/intraductal_carcinoma_noninfiltrating_nos/common" + Intraductal carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/intraductal_carcinoma_nos/common" + Intraductal papillary adenocarcinoma with invasion: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_adenocarcinoma_with_invasion/common" + Intraductal papillary adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_adenocarcinoma_nos/common" + Intraductal papillary carcinoma: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_carcinoma/common" + Intraductal papillary mucinous neoplasm (IPMN) with an associated invasive carcinoma: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_mucinous_neoplasm_ipmn_with_an_associated_invasive_carcinoma/common" + Intraductal papillary mucinous neoplasm with high grade dysplasia: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_mucinous_neoplasm_with_high_grade_dysplasia/common" + Intraductal papillary neoplasm with associated invasive carcinoma: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_neoplasm_with_associated_invasive_carcinoma/common" + Intraductal papillary neoplasm with high grade intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_neoplasm_with_high_grade_intraepithelial_neoplasia/common" + Intraductal papillary neoplasm with intermediate grade neoplasia: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_neoplasm_with_intermediate_grade_neoplasia/common" + Intraductal papillary neoplasm with low grade intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_neoplasm_with_low_grade_intraepithelial_neoplasia/common" + Intraductal papillary neoplasm, NOS: + $ref: + - "_terms_enum.yaml#/intraductal_papillary_neoplasm_nos/common" + Intraductal papilloma: + $ref: + - "_terms_enum.yaml#/intraductal_papilloma/common" + Intraductal papillomatosis, NOS: + $ref: + - "_terms_enum.yaml#/intraductal_papillomatosis_nos/common" + Intraductal tubulopapillary neoplasm: + $ref: + - "_terms_enum.yaml#/intraductal_tubulopapillary_neoplasm/common" + Intraepidermal carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/intraepidermal_carcinoma_nos/common" + Intraepidermal epithelioma of Jadassohn: + $ref: + - "_terms_enum.yaml#/intraepidermal_epithelioma_of_jadassohn/common" + Intraepidermal nevus: + $ref: + - "_terms_enum.yaml#/intraepidermal_nevus/common" + Intraepidermal squamous cell carcinoma, Bowen type: + $ref: + - "_terms_enum.yaml#/intraepidermal_squamous_cell_carcinoma_bowen_type/common" + Intraepithelial carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/intraepithelial_carcinoma_nos/common" + Intraepithelial squamous cell carcinoma: + $ref: + - "_terms_enum.yaml#/intraepithelial_squamous_cell_carcinoma/common" + Intraglandular papillary neoplasm with low grade intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/intraglandular_papillary_neoplasm_with_low_grade_intraepithelial_neoplasia/common" + Intramuscular hemangioma: + $ref: + - "_terms_enum.yaml#/intramuscular_hemangioma/common" + Intramuscular lipoma: + $ref: + - "_terms_enum.yaml#/intramuscular_lipoma/common" + Intraneural perineurioma: + $ref: + - "_terms_enum.yaml#/intraneural_perineurioma/common" + Intraosseous low grade osteosarcoma: + $ref: + - "_terms_enum.yaml#/intraosseous_low_grade_osteosarcoma/common" + Intraosseous well differentiated osteosarcoma: + $ref: + - "_terms_enum.yaml#/intraosseous_well_differentiated_osteosarcoma/common" + Intravascular B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/intravascular_bcell_lymphoma/common" + Intravascular large B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/intravascular_large_bcell_lymphoma/common" + Invasive encapsulated follicular variant of papillary thyroid carcinoma (invasive EFVPTC): + $ref: + - "_terms_enum.yaml#/invasive_encapsulated_follicular_variant_of_papillary_thyroid_carcinoma_invasive_efvptc/common" + Invasive fibroma: + $ref: + - "_terms_enum.yaml#/invasive_fibroma/common" + Invasive hydatidiform mole: + $ref: + - "_terms_enum.yaml#/invasive_hydatidiform_mole/common" + Invasive lobular carcinoma: + $ref: + - "_terms_enum.yaml#/invasive_lobular_carcinoma/common" + Invasive lobular carcinoma, alveolar type: + $ref: + - "_terms_enum.yaml#/invasive_lobular_carcinoma_alveolar_type/common" + Invasive lobular carcinoma, solid type: + $ref: + - "_terms_enum.yaml#/invasive_lobular_carcinoma_solid_type/common" + Invasive lobular carcinoma, tubulolobular variant: + $ref: + - "_terms_enum.yaml#/invasive_lobular_carcinoma_tubulolobular_variant/common" + Invasive mammary carcinoma: + $ref: + - "_terms_enum.yaml#/invasive_mammary_carcinoma/common" + Invasive micropapillary carcinoma: + $ref: + - "_terms_enum.yaml#/invasive_micropapillary_carcinoma/common" + Invasive mole, NOS: + $ref: + - "_terms_enum.yaml#/invasive_mole_nos/common" + Invasive mucinous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/invasive_mucinous_adenocarcinoma/common" + Islet cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/islet_cell_adenocarcinoma/common" + Islet cell adenoma: + $ref: + - "_terms_enum.yaml#/islet_cell_adenoma/common" + Islet cell adenomatosis: + $ref: + - "_terms_enum.yaml#/islet_cell_adenomatosis/common" + Islet cell carcinoma: + $ref: + - "_terms_enum.yaml#/islet_cell_carcinoma/common" + Islet cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/islet_cell_tumor_nos/common" + Jadassohn blue nevus: + $ref: + - "_terms_enum.yaml#/jadassohn_blue_nevus/common" + Jugular paraganglioma: + $ref: + - "_terms_enum.yaml#/jugular_paraganglioma/common" + Jugulotympanic paraganglioma: + $ref: + - "_terms_enum.yaml#/jugulotympanic_paraganglioma/common" + Junction nevus: + $ref: + - "_terms_enum.yaml#/junction_nevus/common" + Junctional nevus, NOS: + $ref: + - "_terms_enum.yaml#/junctional_nevus_nos/common" + Juvenile angiofibroma: + $ref: + - "_terms_enum.yaml#/juvenile_angiofibroma/common" + Juvenile astrocytoma: + $ref: + - "_terms_enum.yaml#/juvenile_astrocytoma/common" + Juvenile carcinoma of breast: + $ref: + - "_terms_enum.yaml#/juvenile_carcinoma_of_breast/common" + Juvenile chronic myelomonocytic leukemia: + $ref: + - "_terms_enum.yaml#/juvenile_chronic_myelomonocytic_leukemia/common" + Juvenile fibroadenoma: + $ref: + - "_terms_enum.yaml#/juvenile_fibroadenoma/common" + Juvenile hemangioma: + $ref: + - "_terms_enum.yaml#/juvenile_hemangioma/common" + Juvenile histiocytoma: + $ref: + - "_terms_enum.yaml#/juvenile_histiocytoma/common" + Juvenile melanoma: + $ref: + - "_terms_enum.yaml#/juvenile_melanoma/common" + Juvenile myelomonocytic leukemia: + $ref: + - "_terms_enum.yaml#/juvenile_myelomonocytic_leukemia/common" + Juvenile nevus: + $ref: + - "_terms_enum.yaml#/juvenile_nevus/common" + Juxtacortical chondroma: + $ref: + - "_terms_enum.yaml#/juxtacortical_chondroma/common" + Juxtacortical chondrosarcoma: + $ref: + - "_terms_enum.yaml#/juxtacortical_chondrosarcoma/common" + Juxtacortical osteosarcoma: + $ref: + - "_terms_enum.yaml#/juxtacortical_osteosarcoma/common" + Juxtaglomerular tumor: + $ref: + - "_terms_enum.yaml#/juxtaglomerular_tumor/common" + Kaposi sarcoma: + $ref: + - "_terms_enum.yaml#/kaposi_sarcoma/common" + Kaposiform hemangioendothelioma: + $ref: + - "_terms_enum.yaml#/kaposiform_hemangioendothelioma/common" + Keratotoc papilloma: + $ref: + - "_terms_enum.yaml#/keratotoc_papilloma/common" + Klatskin tumor: + $ref: + - "_terms_enum.yaml#/klatskin_tumor/common" + Krukenberg tumor: + $ref: + - "_terms_enum.yaml#/krukenberg_tumor/common" + Lactating adenoma: + $ref: + - "_terms_enum.yaml#/lactating_adenoma/common" + Langerhans cell granulomatosis: + $ref: + - "_terms_enum.yaml#/langerhans_cell_granulomatosis/common" + Langerhans cell granulomatosis, unifocal: + $ref: + - "_terms_enum.yaml#/langerhans_cell_granulomatosis_unifocal/common" + Langerhans cell histiocytosis, disseminated: + $ref: + - "_terms_enum.yaml#/langerhans_cell_histiocytosis_disseminated/common" + Langerhans cell histiocytosis, generalized: + $ref: + - "_terms_enum.yaml#/langerhans_cell_histiocytosis_generalized/common" + Langerhans cell histiocytosis, mono-ostotic: + $ref: + - "_terms_enum.yaml#/langerhans_cell_histiocytosis_monoostotic/common" + Langerhans cell histiocytosis, multifocal: + $ref: + - "_terms_enum.yaml#/langerhans_cell_histiocytosis_multifocal/common" + Langerhans cell histiocytosis, NOS: + $ref: + - "_terms_enum.yaml#/langerhans_cell_histiocytosis_nos/common" + Langerhans cell histiocytosis, poly-ostotic: + $ref: + - "_terms_enum.yaml#/langerhans_cell_histiocytosis_polyostotic/common" + Langerhans cell histiocytosis, unifocal: + $ref: + - "_terms_enum.yaml#/langerhans_cell_histiocytosis_unifocal/common" + Langerhans cell sarcoma: + $ref: + - "_terms_enum.yaml#/langerhans_cell_sarcoma/common" + Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease: + $ref: + - "_terms_enum.yaml#/large_bcell_lymphoma_arising_in_hhv8associated_multicentric_castleman_disease/common" + Large cell (Ki-1+) lymphoma: + $ref: + - "_terms_enum.yaml#/large_cell_ki1_lymphoma/common" + Large cell carcinoma with rhabdoid phenotype: + $ref: + - "_terms_enum.yaml#/large_cell_carcinoma_with_rhabdoid_phenotype/common" + Large cell carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/large_cell_carcinoma_nos/common" + Large cell medulloblastoma: + $ref: + - "_terms_enum.yaml#/large_cell_medulloblastoma/common" + Large cell neuroendocrine carcinoma: + $ref: + - "_terms_enum.yaml#/large_cell_neuroendocrine_carcinoma/common" + LCIS, NOS: + $ref: + - "_terms_enum.yaml#/lcis_nos/common" + Leiomyoblastoma: + $ref: + - "_terms_enum.yaml#/leiomyoblastoma/common" + Leiomyofibroma: + $ref: + - "_terms_enum.yaml#/leiomyofibroma/common" + Leiomyoma, NOS: + $ref: + - "_terms_enum.yaml#/leiomyoma_nos/common" + Leiomyomatosis, NOS: + $ref: + - "_terms_enum.yaml#/leiomyomatosis_nos/common" + Leiomyosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/leiomyosarcoma_nos/common" + Lennert lymphoma: + $ref: + - "_terms_enum.yaml#/lennert_lymphoma/common" + Lentigo maligna: + $ref: + - "_terms_enum.yaml#/lentigo_maligna/common" + Lentigo maligna melanoma: + $ref: + - "_terms_enum.yaml#/lentigo_maligna_melanoma/common" + Lepidic predominant adenocarcinoma: + $ref: + - "_terms_enum.yaml#/lepidic_predominant_adenocarcinoma/common" + Leptomeningeal sarcoma: + $ref: + - "_terms_enum.yaml#/leptomeningeal_sarcoma/common" + Letterer-Siwe disease: + $ref: + - "_terms_enum.yaml#/letterersiwe_disease/common" + Leukemia, NOS: + $ref: + - "_terms_enum.yaml#/leukemia_nos/common" + Leukemic reticuloendotheliosis: + $ref: + - "_terms_enum.yaml#/leukemic_reticuloendotheliosis/common" + Leydig cell tumor, benign: + $ref: + - "_terms_enum.yaml#/leydig_cell_tumor_benign/common" + Leydig cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/leydig_cell_tumor_malignant/common" + Leydig cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/leydig_cell_tumor_nos/common" + Linitis plastica: + $ref: + - "_terms_enum.yaml#/linitis_plastica/common" + Lipid cell tumor of ovary: + $ref: + - "_terms_enum.yaml#/lipid_cell_tumor_of_ovary/common" + Lipid-rich carcinoma: + $ref: + - "_terms_enum.yaml#/lipidrich_carcinoma/common" + Lipid-rich urothelial carcinoma: + $ref: + - "_terms_enum.yaml#/lipidrich_urothelial_carcinoma/common" + Lipoadenoma: + $ref: + - "_terms_enum.yaml#/lipoadenoma/common" + Lipoblastoma: + $ref: + - "_terms_enum.yaml#/lipoblastoma/common" + Lipoblastomatosis: + $ref: + - "_terms_enum.yaml#/lipoblastomatosis/common" + Lipoid cell tumor of ovary: + $ref: + - "_terms_enum.yaml#/lipoid_cell_tumor_of_ovary/common" + Lipoleiomyoma: + $ref: + - "_terms_enum.yaml#/lipoleiomyoma/common" + Lipoma, NOS: + $ref: + - "_terms_enum.yaml#/lipoma_nos/common" + Lipoma-like liposarcoma: + $ref: + - "_terms_enum.yaml#/lipomalike_liposarcoma/common" + Lipomatous medulloblastoma: + $ref: + - "_terms_enum.yaml#/lipomatous_medulloblastoma/common" + Liposarcoma, differentiated: + $ref: + - "_terms_enum.yaml#/liposarcoma_differentiated/common" + Liposarcoma, NOS: + $ref: + - "_terms_enum.yaml#/liposarcoma_nos/common" + Liposarcoma, well differentiated: + $ref: + - "_terms_enum.yaml#/liposarcoma_well_differentiated/common" + Liver cell adenoma: + $ref: + - "_terms_enum.yaml#/liver_cell_adenoma/common" + Liver cell carcinoma: + $ref: + - "_terms_enum.yaml#/liver_cell_carcinoma/common" + Lobular adenocarcinoma: + $ref: + - "_terms_enum.yaml#/lobular_adenocarcinoma/common" + Lobular and ductal carcinoma: + $ref: + - "_terms_enum.yaml#/lobular_and_ductal_carcinoma/common" + Lobular carcinoma in situ, NOS: + $ref: + - "_terms_enum.yaml#/lobular_carcinoma_in_situ_nos/common" + Lobular carcinoma, noninfiltrating: + $ref: + - "_terms_enum.yaml#/lobular_carcinoma_noninfiltrating/common" + Lobular carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/lobular_carcinoma_nos/common" + Localized fibrous tumor: + $ref: + - "_terms_enum.yaml#/localized_fibrous_tumor/common" + Low grade adenosquamous carcinoma: + $ref: + - "_terms_enum.yaml#/low_grade_adenosquamous_carcinoma/common" + Low grade appendiceal mucinous neoplasm: + $ref: + - "_terms_enum.yaml#/low_grade_appendiceal_mucinous_neoplasm/common" + Low grade cribriform cystadenocarcinoma (LGCCC): + $ref: + - "_terms_enum.yaml#/low_grade_cribriform_cystadenocarcinoma_lgccc/common" + Low-grade central osteosarcoma: + $ref: + - "_terms_enum.yaml#/lowgrade_central_osteosarcoma/common" + Low-grade fibromyxoid sarcoma: + $ref: + - "_terms_enum.yaml#/lowgrade_fibromyxoid_sarcoma/common" + Low-grade intramedullary osteosarcoma: + $ref: + - "_terms_enum.yaml#/lowgrade_intramedullary_osteosarcoma/common" + Low-grade myofibroblastic sarcoma: + $ref: + - "_terms_enum.yaml#/lowgrade_myofibroblastic_sarcoma/common" + Luteinoma: + $ref: + - "_terms_enum.yaml#/luteinoma/common" + Luteoma, NOS: + $ref: + - "_terms_enum.yaml#/luteoma_nos/common" + Lymphangioendothelial sarcoma: + $ref: + - "_terms_enum.yaml#/lymphangioendothelial_sarcoma/common" + Lymphangioendothelioma, malignant: + $ref: + - "_terms_enum.yaml#/lymphangioendothelioma_malignant/common" + Lymphangioendothelioma, NOS: + $ref: + - "_terms_enum.yaml#/lymphangioendothelioma_nos/common" + Lymphangioleiomyomatosis: + $ref: + - "_terms_enum.yaml#/lymphangioleiomyomatosis/common" + Lymphangioma, NOS: + $ref: + - "_terms_enum.yaml#/lymphangioma_nos/common" + Lymphangiomyoma: + $ref: + - "_terms_enum.yaml#/lymphangiomyoma/common" + Lymphangiomyomatosis: + $ref: + - "_terms_enum.yaml#/lymphangiomyomatosis/common" + Lymphangiosarcoma: + $ref: + - "_terms_enum.yaml#/lymphangiosarcoma/common" + Lymphatic leukemic, NOS: + $ref: + - "_terms_enum.yaml#/lymphatic_leukemic_nos/common" + Lymphoblastic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/lymphoblastic_leukemia_nos/common" + Lymphoblastoma: + $ref: + - "_terms_enum.yaml#/lymphoblastoma/common" + Lymphocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/lymphocytic_leukemia_nos/common" + Lymphoepithelial carcinoma: + $ref: + - "_terms_enum.yaml#/lymphoepithelial_carcinoma/common" + Lymphoepithelioid lymphoma: + $ref: + - "_terms_enum.yaml#/lymphoepithelioid_lymphoma/common" + Lymphoepithelioma: + $ref: + - "_terms_enum.yaml#/lymphoepithelioma/common" + Lymphoepithelioma-like carcinoma: + $ref: + - "_terms_enum.yaml#/lymphoepitheliomalike_carcinoma/common" + Lymphoid leukemia, NOS: + $ref: + - "_terms_enum.yaml#/lymphoid_leukemia_nos/common" + Lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/lymphoma_nos/common" + Lymphomatoid granulomatosis: + $ref: + - "_terms_enum.yaml#/lymphomatoid_granulomatosis/common" + Lymphomatoid papulosis: + $ref: + - "_terms_enum.yaml#/lymphomatoid_papulosis/common" + Lymphoplasmacyte-rich meningioma: + $ref: + - "_terms_enum.yaml#/lymphoplasmacyterich_meningioma/common" + Lymphoproliferative disease, NOS: + $ref: + - "_terms_enum.yaml#/lymphoproliferative_disease_nos/common" + Lymphoproliferative disorder, NOS: + $ref: + - "_terms_enum.yaml#/lymphoproliferative_disorder_nos/common" + Lymphosarcoma cell leukemia: + $ref: + - "_terms_enum.yaml#/lymphosarcoma_cell_leukemia/common" + Lymphosarcoma, diffuse: + $ref: + - "_terms_enum.yaml#/lymphosarcoma_diffuse/common" + Lymphosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/lymphosarcoma_nos/common" + M6A: + $ref: + - "_terms_enum.yaml#/m6a/common" + M6B: + $ref: + - "_terms_enum.yaml#/m6b/common" + Macrofollicular adenoma: + $ref: + - "_terms_enum.yaml#/macrofollicular_adenoma/common" + Magnocellular nevus: + $ref: + - "_terms_enum.yaml#/magnocellular_nevus/common" + Malignancy: + $ref: + - "_terms_enum.yaml#/malignancy/common" + Malignant cystic nephroma: + $ref: + - "_terms_enum.yaml#/malignant_cystic_nephroma/common" + Malignant eccrine spiradenoma: + $ref: + - "_terms_enum.yaml#/malignant_eccrine_spiradenoma/common" + Malignant fibrous histiocytoma: + $ref: + - "_terms_enum.yaml#/malignant_fibrous_histiocytoma/common" + Malignant giant cell tumor of soft parts: + $ref: + - "_terms_enum.yaml#/malignant_giant_cell_tumor_of_soft_parts/common" + Malignant histiocytosis: + $ref: + - "_terms_enum.yaml#/malignant_histiocytosis/common" + Malignant hydatidiform mole: + $ref: + - "_terms_enum.yaml#/malignant_hydatidiform_mole/common" + Malignant lymphoma, centroblastic, diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_centroblastic_diffuse/common" + Malignant lymphoma, centroblastic, follicular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_centroblastic_follicular/common" + Malignant lymphoma, centroblastic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_centroblastic_nos/common" + Malignant lymphoma, centroblasticcentrocytic, diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_centroblasticcentrocytic_diffuse/common" + Malignant lymphoma, centroblasticcentrocytic, follicular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_centroblasticcentrocytic_follicular/common" + Malignant lymphoma, centroblasticcentrocytic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_centroblasticcentrocytic_nos/common" + Malignant lymphoma, convoluted cell: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_convoluted_cell/common" + Malignant lymphoma, diffuse, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_diffuse_nos/common" + Malignant lymphoma, follicle center, follicular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_follicle_center_follicular/common" + Malignant lymphoma, follicle center, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_follicle_center_nos/common" + Malignant lymphoma, follicular, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_follicular_nos/common" + Malignant lymphoma, histiocytic, diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_histiocytic_diffuse/common" + Malignant lymphoma, histiocytic, nodular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_histiocytic_nodular/common" + Malignant lymphoma, histiocytic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_histiocytic_nos/common" + Malignant lymphoma, Hodgkin: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_hodgkin/common" + Malignant lymphoma, immunoblastic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_immunoblastic_nos/common" + Malignant lymphoma, large B-cell, diffuse, centroblastic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_bcell_diffuse_centroblastic_nos/common" + Malignant lymphoma, large B-cell, diffuse, immunoblastic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_bcell_diffuse_immunoblastic_nos/common" + Malignant lymphoma, large B-cell, diffuse, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_bcell_diffuse_nos/common" + Malignant lymphoma, large B-cell, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_bcell_nos/common" + Malignant lymphoma, large cell, cleaved and noncleaved: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_cleaved_and_noncleaved/common" + Malignant lymphoma, large cell, cleaved, diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_cleaved_diffuse/common" + Malignant lymphoma, large cell, cleaved, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_cleaved_nos/common" + Malignant lymphoma, large cell, diffuse, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_diffuse_nos/common" + Malignant lymphoma, large cell, follicular, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_follicular_nos/common" + Malignant lymphoma, large cell, immunoblastic: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_immunoblastic/common" + Malignant lymphoma, large cell, noncleaved, diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_noncleaved_diffuse/common" + Malignant lymphoma, large cell, noncleaved, follicular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_noncleaved_follicular/common" + Malignant lymphoma, large cell, noncleaved, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_noncleaved_nos/common" + Malignant lymphoma, large cell, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cell_nos/common" + Malignant lymphoma, large cleaved cell, follicular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cleaved_cell_follicular/common" + Malignant lymphoma, large cleaved cell, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_large_cleaved_cell_nos/common" + Malignant lymphoma, lymphoblastic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphoblastic_nos/common" + Malignant lymphoma, lymphocytic, diffuse, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphocytic_diffuse_nos/common" + Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphocytic_intermediate_differentiation_diffuse/common" + Malignant lymphoma, lymphocytic, nodular, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphocytic_nodular_nos/common" + Malignant lymphoma, lymphocytic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphocytic_nos/common" + Malignant lymphoma, lymphocytic, poorly differentiated, nodular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphocytic_poorly_differentiated_nodular/common" + Malignant lymphoma, lymphocytic, well differentiated, diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphocytic_well_differentiated_diffuse/common" + Malignant lymphoma, lymphoplasmacytic: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphoplasmacytic/common" + Malignant lymphoma, lymphoplasmacytoid: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_lymphoplasmacytoid/common" + Malignant lymphoma, mixed cell type, follicular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_mixed_cell_type_follicular/common" + Malignant lymphoma, mixed cell type, nodular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_mixed_cell_type_nodular/common" + Malignant lymphoma, mixed lymphocytic-histiocytic, nodular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_mixed_lymphocytichistiocytic_nodular/common" + Malignant lymphoma, mixed small cleaved and large cell, follicular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_mixed_small_cleaved_and_large_cell_follicular/common" + Malignant lymphoma, nodular, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_nodular_nos/common" + Malignant lymphoma, non-cleaved cell, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_noncleaved_cell_nos/common" + Malignant lymphoma, non-Hodgkin, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_nonhodgkin_nos/common" + Malignant lymphoma, noncleaved, diffuse, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_noncleaved_diffuse_nos/common" + Malignant lymphoma, noncleaved, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_noncleaved_nos/common" + Malignant lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_nos/common" + Malignant lymphoma, plasmacytoid: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_plasmacytoid/common" + Malignant lymphoma, small B lymphocytic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_small_b_lymphocytic_nos/common" + Malignant lymphoma, small cell diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_small_cell_diffuse/common" + Malignant lymphoma, small cell, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_small_cell_nos/common" + Malignant lymphoma, small cleaved cell, follicular: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_small_cleaved_cell_follicular/common" + Malignant lymphoma, small lymphocytic, diffuse: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_small_lymphocytic_diffuse/common" + Malignant lymphoma, small lymphocytic, NOS: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_small_lymphocytic_nos/common" + Malignant lymphoma, small noncleaved, Burkitt type: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_small_noncleaved_burkitt_type/common" + Malignant lymphoma, undifferentiated, Burkitt type: + $ref: + - "_terms_enum.yaml#/malignant_lymphoma_undifferentiated_burkitt_type/common" + Malignant lymphomatous polyposis: + $ref: + - "_terms_enum.yaml#/malignant_lymphomatous_polyposis/common" + Malignant mast cell tumor: + $ref: + - "_terms_enum.yaml#/malignant_mast_cell_tumor/common" + Malignant mastocytoma: + $ref: + - "_terms_enum.yaml#/malignant_mastocytoma/common" + Malignant mastocytosis: + $ref: + - "_terms_enum.yaml#/malignant_mastocytosis/common" + Malignant melanoma in Hutchinson melanotic freckle: + $ref: + - "_terms_enum.yaml#/malignant_melanoma_in_hutchinson_melanotic_freckle/common" + Malignant melanoma in junctional nevus: + $ref: + - "_terms_enum.yaml#/malignant_melanoma_in_junctional_nevus/common" + Malignant melanoma in precancerous melanosis: + $ref: + - "_terms_enum.yaml#/malignant_melanoma_in_precancerous_melanosis/common" + Malignant melanoma, NOS: + $ref: + - "_terms_enum.yaml#/malignant_melanoma_nos/common" + Malignant melanoma, regressing: + $ref: + - "_terms_enum.yaml#/malignant_melanoma_regressing/common" + Malignant multilocular cystic nephroma: + $ref: + - "_terms_enum.yaml#/malignant_multilocular_cystic_nephroma/common" + Malignant myoepithelioma: + $ref: + - "_terms_enum.yaml#/malignant_myoepithelioma/common" + Malignant peripheral nerve sheath tumor: + $ref: + - "_terms_enum.yaml#/malignant_peripheral_nerve_sheath_tumor/common" + Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation: + $ref: + - "_terms_enum.yaml#/malignant_peripheral_nerve_sheath_tumor_with_rhabdomyoblastic_differentiation/common" + Malignant perivascular epithelial cell tumor: + $ref: + - "_terms_enum.yaml#/malignant_perivascular_epithelial_cell_tumor/common" + Malignant reticulosis, NOS: + $ref: + - "_terms_enum.yaml#/malignant_reticulosis_nos/common" + Malignant rhabdoid tumor: + $ref: + - "_terms_enum.yaml#/malignant_rhabdoid_tumor/common" + Malignant schwannoma with rhabdomyoblastic differentiation: + $ref: + - "_terms_enum.yaml#/malignant_schwannoma_with_rhabdomyoblastic_differentiation/common" + Malignant schwannoma, NOS: + $ref: + - "_terms_enum.yaml#/malignant_schwannoma_nos/common" + Malignant tenosynovial giant cell tumor: + $ref: + - "_terms_enum.yaml#/malignant_tenosynovial_giant_cell_tumor/common" + Malignant teratoma, anaplastic: + $ref: + - "_terms_enum.yaml#/malignant_teratoma_anaplastic/common" + Malignant teratoma, intermediate: + $ref: + - "_terms_enum.yaml#/malignant_teratoma_intermediate/common" + Malignant teratoma, trophoblastic: + $ref: + - "_terms_enum.yaml#/malignant_teratoma_trophoblastic/common" + Malignant teratoma, undifferentiated: + $ref: + - "_terms_enum.yaml#/malignant_teratoma_undifferentiated/common" + Malignant tumor, fusiform cell type: + $ref: + - "_terms_enum.yaml#/malignant_tumor_fusiform_cell_type/common" + Malignant tumor, giant cell type: + $ref: + - "_terms_enum.yaml#/malignant_tumor_giant_cell_type/common" + Malignant tumor, small cell type: + $ref: + - "_terms_enum.yaml#/malignant_tumor_small_cell_type/common" + Malignant tumor, spindle cell type: + $ref: + - "_terms_enum.yaml#/malignant_tumor_spindle_cell_type/common" + MALT lymphoma: + $ref: + - "_terms_enum.yaml#/malt_lymphoma/common" + MANEC: + $ref: + - "_terms_enum.yaml#/manec/common" + Mantle cell lymphoma (Includes all variants blastic, pleomorphic, small cell): + $ref: + - "_terms_enum.yaml#/mantle_cell_lymphoma_includes_all_variants_blastic_pleomorphic_small_cell/common" + Mantle zone lymphoma: + $ref: + - "_terms_enum.yaml#/mantle_zone_lymphoma/common" + Marginal zone B-cell lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/marginal_zone_bcell_lymphoma_nos/common" + Marginal zone lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/marginal_zone_lymphoma_nos/common" + Masculinovoblastoma: + $ref: + - "_terms_enum.yaml#/masculinovoblastoma/common" + Mast cell leukaemia: + $ref: + - "_terms_enum.yaml#/mast_cell_leukaemia/common" + Mast cell sarcoma: + $ref: + - "_terms_enum.yaml#/mast_cell_sarcoma/common" + Mast cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/mast_cell_tumor_nos/common" + Mastocytoma, NOS: + $ref: + - "_terms_enum.yaml#/mastocytoma_nos/common" + Matrical carcinoma: + $ref: + - "_terms_enum.yaml#/matrical_carcinoma/common" + Mature T ALL: + $ref: + - "_terms_enum.yaml#/mature_t_all/common" + Mature T-cell lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/mature_tcell_lymphoma_nos/common" + Mature teratoma: + $ref: + - "_terms_enum.yaml#/mature_teratoma/common" + Mediastinal (thymic) large B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/mediastinal_thymic_large_bcell_lymphoma/common" + Mediterranean lymphoma: + $ref: + - "_terms_enum.yaml#/mediterranean_lymphoma/common" + Medullary carcinoma with amyloid stroma: + $ref: + - "_terms_enum.yaml#/medullary_carcinoma_with_amyloid_stroma/common" + Medullary carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/medullary_carcinoma_nos/common" + Medullary osteosarcoma: + $ref: + - "_terms_enum.yaml#/medullary_osteosarcoma/common" + Medulloblastoma with extensive nodularity: + $ref: + - "_terms_enum.yaml#/medulloblastoma_with_extensive_nodularity/common" + Medulloblastoma, classic: + $ref: + - "_terms_enum.yaml#/medulloblastoma_classic/common" + Medulloblastoma, group 3: + $ref: + - "_terms_enum.yaml#/medulloblastoma_group_3/common" + Medulloblastoma, group 4: + $ref: + - "_terms_enum.yaml#/medulloblastoma_group_4/common" + Medulloblastoma, non-WNT/non-SHH: + $ref: + - "_terms_enum.yaml#/medulloblastoma_nonwntnonshh/common" + Medulloblastoma, NOS: + $ref: + - "_terms_enum.yaml#/medulloblastoma_nos/common" + Medulloblastoma, SHH-activated and TP53-mutant: + $ref: + - "_terms_enum.yaml#/medulloblastoma_shhactivated_and_tp53mutant/common" + Medulloblastoma, SHH-activated and TP53-wildtype: + $ref: + - "_terms_enum.yaml#/medulloblastoma_shhactivated_and_tp53wildtype/common" + Medulloblastoma, WNT-activated: + $ref: + - "_terms_enum.yaml#/medulloblastoma_wntactivated/common" + Medullocytoma: + $ref: + - "_terms_enum.yaml#/medullocytoma/common" + Medulloepithelioma, NOS: + $ref: + - "_terms_enum.yaml#/medulloepithelioma_nos/common" + Medullomyoblastoma: + $ref: + - "_terms_enum.yaml#/medullomyoblastoma/common" + Megakaryocytic leukemia: + $ref: + - "_terms_enum.yaml#/megakaryocytic_leukemia/common" + Megakaryocytic myelosclerosis: + $ref: + - "_terms_enum.yaml#/megakaryocytic_myelosclerosis/common" + Melanoameloblastoma: + $ref: + - "_terms_enum.yaml#/melanoameloblastoma/common" + Melanocytic nevus: + $ref: + - "_terms_enum.yaml#/melanocytic_nevus/common" + Melanocytoma, eyeball: + $ref: + - "_terms_enum.yaml#/melanocytoma_eyeball/common" + Melanocytoma, NOS: + $ref: + - "_terms_enum.yaml#/melanocytoma_nos/common" + Melanoma in situ: + $ref: + - "_terms_enum.yaml#/melanoma_in_situ/common" + Melanoma, malignant, of soft parts: + $ref: + - "_terms_enum.yaml#/melanoma_malignant_of_soft_parts/common" + Melanoma, NOS: + $ref: + - "_terms_enum.yaml#/melanoma_nos/common" + Melanotic medulloblastoma: + $ref: + - "_terms_enum.yaml#/melanotic_medulloblastoma/common" + Melanotic MPNST: + $ref: + - "_terms_enum.yaml#/melanotic_mpnst/common" + Melanotic neuroectodermal tumor: + $ref: + - "_terms_enum.yaml#/melanotic_neuroectodermal_tumor/common" + Melanotic neurofibroma: + $ref: + - "_terms_enum.yaml#/melanotic_neurofibroma/common" + Melanotic progonoma: + $ref: + - "_terms_enum.yaml#/melanotic_progonoma/common" + Melanotic psammomatous MPNST: + $ref: + - "_terms_enum.yaml#/melanotic_psammomatous_mpnst/common" + Melanotic schwannoma: + $ref: + - "_terms_enum.yaml#/melanotic_schwannoma/common" + Meningeal melanocytoma: + $ref: + - "_terms_enum.yaml#/meningeal_melanocytoma/common" + Meningeal melanoma: + $ref: + - "_terms_enum.yaml#/meningeal_melanoma/common" + Meningeal melanomatosis: + $ref: + - "_terms_enum.yaml#/meningeal_melanomatosis/common" + Meningeal sarcoma: + $ref: + - "_terms_enum.yaml#/meningeal_sarcoma/common" + Meningeal sarcomatosis: + $ref: + - "_terms_enum.yaml#/meningeal_sarcomatosis/common" + Meningioma, anaplastic: + $ref: + - "_terms_enum.yaml#/meningioma_anaplastic/common" + Meningioma, malignant: + $ref: + - "_terms_enum.yaml#/meningioma_malignant/common" + Meningioma, NOS: + $ref: + - "_terms_enum.yaml#/meningioma_nos/common" + Meningiomatosis, NOS: + $ref: + - "_terms_enum.yaml#/meningiomatosis_nos/common" + Meningothelial meningioma: + $ref: + - "_terms_enum.yaml#/meningothelial_meningioma/common" + Meningothelial sarcoma: + $ref: + - "_terms_enum.yaml#/meningothelial_sarcoma/common" + Merkel cell carcinoma: + $ref: + - "_terms_enum.yaml#/merkel_cell_carcinoma/common" + Merkel cell tumor: + $ref: + - "_terms_enum.yaml#/merkel_cell_tumor/common" + Mesenchymal chondrosarcoma: + $ref: + - "_terms_enum.yaml#/mesenchymal_chondrosarcoma/common" + Mesenchymal tumor, malignant: + $ref: + - "_terms_enum.yaml#/mesenchymal_tumor_malignant/common" + Mesenchymoma, benign: + $ref: + - "_terms_enum.yaml#/mesenchymoma_benign/common" + Mesenchymoma, malignant: + $ref: + - "_terms_enum.yaml#/mesenchymoma_malignant/common" + Mesenchymoma, NOS: + $ref: + - "_terms_enum.yaml#/mesenchymoma_nos/common" + Mesenteric fibromatosis: + $ref: + - "_terms_enum.yaml#/mesenteric_fibromatosis/common" + Mesoblastic nephroma: + $ref: + - "_terms_enum.yaml#/mesoblastic_nephroma/common" + Mesodermal mixed tumor: + $ref: + - "_terms_enum.yaml#/mesodermal_mixed_tumor/common" + Mesonephric adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mesonephric_adenocarcinoma/common" + Mesonephric adenoma: + $ref: + - "_terms_enum.yaml#/mesonephric_adenoma/common" + Mesonephric tumor, NOS: + $ref: + - "_terms_enum.yaml#/mesonephric_tumor_nos/common" + Mesonephroma, benign: + $ref: + - "_terms_enum.yaml#/mesonephroma_benign/common" + Mesonephroma, malignant: + $ref: + - "_terms_enum.yaml#/mesonephroma_malignant/common" + Mesonephroma, NOS: + $ref: + - "_terms_enum.yaml#/mesonephroma_nos/common" + Mesothelioma, benign: + $ref: + - "_terms_enum.yaml#/mesothelioma_benign/common" + Mesothelioma, biphasic, malignant: + $ref: + - "_terms_enum.yaml#/mesothelioma_biphasic_malignant/common" + Mesothelioma, biphasic, NOS: + $ref: + - "_terms_enum.yaml#/mesothelioma_biphasic_nos/common" + Mesothelioma, malignant: + $ref: + - "_terms_enum.yaml#/mesothelioma_malignant/common" + Mesothelioma, NOS: + $ref: + - "_terms_enum.yaml#/mesothelioma_nos/common" + Metanephric adenoma: + $ref: + - "_terms_enum.yaml#/metanephric_adenoma/common" + Metaplastic carcinoma of no special type: + $ref: + - "_terms_enum.yaml#/metaplastic_carcinoma_of_no_special_type/common" + Metaplastic carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/metaplastic_carcinoma_nos/common" + Metaplastic meningioma: + $ref: + - "_terms_enum.yaml#/metaplastic_meningioma/common" + Metastatic signet ring cell carcinoma: + $ref: + - "_terms_enum.yaml#/metastatic_signet_ring_cell_carcinoma/common" + Metatypical carcinoma: + $ref: + - "_terms_enum.yaml#/metatypical_carcinoma/common" + MGUS: + $ref: + - "_terms_enum.yaml#/mgus/common" + Microcystic adenoma: + $ref: + - "_terms_enum.yaml#/microcystic_adenoma/common" + Microcystic adnexal carcinoma: + $ref: + - "_terms_enum.yaml#/microcystic_adnexal_carcinoma/common" + Microcystic meningioma: + $ref: + - "_terms_enum.yaml#/microcystic_meningioma/common" + Microcystic urothelial carcinoma: + $ref: + - "_terms_enum.yaml#/microcystic_urothelial_carcinoma/common" + Microfollicular adenoma, NOS: + $ref: + - "_terms_enum.yaml#/microfollicular_adenoma_nos/common" + Microglioma: + $ref: + - "_terms_enum.yaml#/microglioma/common" + Micropapillary serous carcinoma: + $ref: + - "_terms_enum.yaml#/micropapillary_serous_carcinoma/common" + Midline carcinoma of children and young adults with NUT rearrangement: + $ref: + - "_terms_enum.yaml#/midline_carcinoma_of_children_and_young_adults_with_nut_rearrangement/common" + Minimally invasive adenocarcinoma, mucinous: + $ref: + - "_terms_enum.yaml#/minimally_invasive_adenocarcinoma_mucinous/common" + Minimally invasive adenocarcinoma, non-mucinous: + $ref: + - "_terms_enum.yaml#/minimally_invasive_adenocarcinoma_nonmucinous/common" + Minimally invasive adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/minimally_invasive_adenocarcinoma_nos/common" + MiT family translocation renal cell carcinoma: + $ref: + - "_terms_enum.yaml#/mit_family_translocation_renal_cell_carcinoma/common" + Mixed acidophil-basophil adenoma: + $ref: + - "_terms_enum.yaml#/mixed_acidophilbasophil_adenoma/common" + Mixed acidophil-basophil carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_acidophilbasophil_carcinoma/common" + Mixed acinar-endocrine-ductal carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_acinarendocrineductal_carcinoma/common" + Mixed adenocarcinoma and epidermoid carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_adenocarcinoma_and_epidermoid_carcinoma/common" + Mixed adenocarcinoma and squamous cell carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_adenocarcinoma_and_squamous_cell_carcinoma/common" + Mixed adenomatous and hyperplastic polyp: + $ref: + - "_terms_enum.yaml#/mixed_adenomatous_and_hyperplastic_polyp/common" + Mixed adenoneuroendocrine carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_adenoneuroendocrine_carcinoma/common" + Mixed basal-squamous cell carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_basalsquamous_cell_carcinoma/common" + Mixed carcinoid-adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mixed_carcinoidadenocarcinoma/common" + Mixed cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mixed_cell_adenocarcinoma/common" + Mixed cell adenoma: + $ref: + - "_terms_enum.yaml#/mixed_cell_adenoma/common" + Mixed ductal-endocrine carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_ductalendocrine_carcinoma/common" + Mixed embryonal carcinoma and teratoma: + $ref: + - "_terms_enum.yaml#/mixed_embryonal_carcinoma_and_teratoma/common" + Mixed epithelioid and spindle cell melanoma: + $ref: + - "_terms_enum.yaml#/mixed_epithelioid_and_spindle_cell_melanoma/common" + Mixed germ cell sex cord-stromal tumor, unclassified: + $ref: + - "_terms_enum.yaml#/mixed_germ_cell_sex_cordstromal_tumor_unclassified/common" + Mixed germ cell tumor: + $ref: + - "_terms_enum.yaml#/mixed_germ_cell_tumor/common" + Mixed glioma: + $ref: + - "_terms_enum.yaml#/mixed_glioma/common" + Mixed hepatocellular and bile duct carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_hepatocellular_and_bile_duct_carcinoma/common" + Mixed liposarcoma: + $ref: + - "_terms_enum.yaml#/mixed_liposarcoma/common" + Mixed meningioma: + $ref: + - "_terms_enum.yaml#/mixed_meningioma/common" + Mixed mesenchymal sarcoma: + $ref: + - "_terms_enum.yaml#/mixed_mesenchymal_sarcoma/common" + Mixed mesenchymal tumor: + $ref: + - "_terms_enum.yaml#/mixed_mesenchymal_tumor/common" + Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1: + $ref: + - "_terms_enum.yaml#/mixed_phenotype_acute_leukemia_with_t922q34q112_bcrabl1/common" + Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged: + $ref: + - "_terms_enum.yaml#/mixed_phenotype_acute_leukemia_with_tv11q23_mll_rearranged/common" + Mixed phenotype acute leukemia, B/myeloid, NOS: + $ref: + - "_terms_enum.yaml#/mixed_phenotype_acute_leukemia_bmyeloid_nos/common" + Mixed phenotype acute leukemia, T/myeloid, NOS: + $ref: + - "_terms_enum.yaml#/mixed_phenotype_acute_leukemia_tmyeloid_nos/common" + Mixed small cell carcinoma: + $ref: + - "_terms_enum.yaml#/mixed_small_cell_carcinoma/common" + Mixed subependymoma-ependymoma: + $ref: + - "_terms_enum.yaml#/mixed_subependymomaependymoma/common" + Mixed teratoma and seminoma: + $ref: + - "_terms_enum.yaml#/mixed_teratoma_and_seminoma/common" + Mixed tumor, malignant, NOS: + $ref: + - "_terms_enum.yaml#/mixed_tumor_malignant_nos/common" + Mixed tumor, NOS: + $ref: + - "_terms_enum.yaml#/mixed_tumor_nos/common" + Mixed tumor, salivary gland type, malignant: + $ref: + - "_terms_enum.yaml#/mixed_tumor_salivary_gland_type_malignant/common" + Mixed tumor, salivary gland type, NOS: + $ref: + - "_terms_enum.yaml#/mixed_tumor_salivary_gland_type_nos/common" + Monoblastic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/monoblastic_leukemia_nos/common" + Monoclonal gammopathy of undetermined significance: + $ref: + - "_terms_enum.yaml#/monoclonal_gammopathy_of_undetermined_significance/common" + Monoclonal gammopathy, NOS: + $ref: + - "_terms_enum.yaml#/monoclonal_gammopathy_nos/common" + Monocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/monocytic_leukemia_nos/common" + Monocytoid B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/monocytoid_bcell_lymphoma/common" + Monomorphic adenoma: + $ref: + - "_terms_enum.yaml#/monomorphic_adenoma/common" + MPNST with rhabdomyoblastic differentiation: + $ref: + - "_terms_enum.yaml#/mpnst_with_rhabdomyoblastic_differentiation/common" + MPNST, NOS: + $ref: + - "_terms_enum.yaml#/mpnst_nos/common" + Mu heavy chain disease: + $ref: + - "_terms_enum.yaml#/mu_heavy_chain_disease/common" + Mucin-producing adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mucinproducing_adenocarcinoma/common" + Mucin-producing carcinoma: + $ref: + - "_terms_enum.yaml#/mucinproducing_carcinoma/common" + Mucin-secreting adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mucinsecreting_adenocarcinoma/common" + Mucin-secreting carcinoma: + $ref: + - "_terms_enum.yaml#/mucinsecreting_carcinoma/common" + Mucinous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mucinous_adenocarcinoma/common" + Mucinous adenocarcinoma, endocervical type: + $ref: + - "_terms_enum.yaml#/mucinous_adenocarcinoma_endocervical_type/common" + Mucinous adenofibroma, NOS: + $ref: + - "_terms_enum.yaml#/mucinous_adenofibroma_nos/common" + Mucinous adenoma: + $ref: + - "_terms_enum.yaml#/mucinous_adenoma/common" + Mucinous carcinoma: + $ref: + - "_terms_enum.yaml#/mucinous_carcinoma/common" + Mucinous carcinoma, gastric type: + $ref: + - "_terms_enum.yaml#/mucinous_carcinoma_gastric_type/common" + Mucinous carcinoma, intestinal type: + $ref: + - "_terms_enum.yaml#/mucinous_carcinoma_intestinal_type/common" + Mucinous cystadenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/mucinous_cystadenocarcinoma_nos/common" + Mucinous cystadenofibroma, NOS: + $ref: + - "_terms_enum.yaml#/mucinous_cystadenofibroma_nos/common" + Mucinous cystadenoma, NOS: + $ref: + - "_terms_enum.yaml#/mucinous_cystadenoma_nos/common" + Mucinous cystic tumor with moderate dysplasia: + $ref: + - "_terms_enum.yaml#/mucinous_cystic_tumor_with_moderate_dysplasia/common" + Mucinous cystoma: + $ref: + - "_terms_enum.yaml#/mucinous_cystoma/common" + Mucinous tubular and spindle cell carcinoma: + $ref: + - "_terms_enum.yaml#/mucinous_tubular_and_spindle_cell_carcinoma/common" + Mucoepidermoid carcinoma: + $ref: + - "_terms_enum.yaml#/mucoepidermoid_carcinoma/common" + Mucoid adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mucoid_adenocarcinoma/common" + Mucoid carcinoma: + $ref: + - "_terms_enum.yaml#/mucoid_carcinoma/common" + Mucoid cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mucoid_cell_adenocarcinoma/common" + Mucoid cell adenoma: + $ref: + - "_terms_enum.yaml#/mucoid_cell_adenoma/common" + Mucosal lentiginous melanoma: + $ref: + - "_terms_enum.yaml#/mucosal_lentiginous_melanoma/common" + Mucosal-associated lymphoid tissue lymphoma: + $ref: + - "_terms_enum.yaml#/mucosalassociated_lymphoid_tissue_lymphoma/common" + Mucous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/mucous_adenocarcinoma/common" + Mucous carcinoma: + $ref: + - "_terms_enum.yaml#/mucous_carcinoma/common" + Mullerian adenosarcoma: + $ref: + - "_terms_enum.yaml#/mullerian_adenosarcoma/common" + Mullerian mixed tumor: + $ref: + - "_terms_enum.yaml#/mullerian_mixed_tumor/common" + Multicentric basal cell carcinoma: + $ref: + - "_terms_enum.yaml#/multicentric_basal_cell_carcinoma/common" + Multifocal superficial basal cell carcinoma: + $ref: + - "_terms_enum.yaml#/multifocal_superficial_basal_cell_carcinoma/common" + Multiple adenomatous polyps: + $ref: + - "_terms_enum.yaml#/multiple_adenomatous_polyps/common" + Multiple endocrine adenomas: + $ref: + - "_terms_enum.yaml#/multiple_endocrine_adenomas/common" + Multiple hemorrhagic sarcoma: + $ref: + - "_terms_enum.yaml#/multiple_hemorrhagic_sarcoma/common" + Multiple meningiomas: + $ref: + - "_terms_enum.yaml#/multiple_meningiomas/common" + Multiple myeloma: + $ref: + - "_terms_enum.yaml#/multiple_myeloma/common" + Multiple neurofibromatosis: + $ref: + - "_terms_enum.yaml#/multiple_neurofibromatosis/common" + Mycosis fungoides: + $ref: + - "_terms_enum.yaml#/mycosis_fungoides/common" + Myelocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/myelocytic_leukemia_nos/common" + Myelodysplastic syndrome with 5q deletion (5q-) syndrome: + $ref: + - "_terms_enum.yaml#/myelodysplastic_syndrome_with_5q_deletion_5q_syndrome/common" + Myelodysplastic syndrome with isolated del (5q): + $ref: + - "_terms_enum.yaml#/myelodysplastic_syndrome_with_isolated_del_5q/common" + Myelodysplastic syndrome, NOS: + $ref: + - "_terms_enum.yaml#/myelodysplastic_syndrome_nos/common" + Myelodysplastic syndrome, unclassifiable: + $ref: + - "_terms_enum.yaml#/myelodysplastic_syndrome_unclassifiable/common" + Myelodysplastic/myeloproliferative neoplasm, unclassifiable: + $ref: + - "_terms_enum.yaml#/myelodysplasticmyeloproliferative_neoplasm_unclassifiable/common" + Myelofibrosis as a result of myeloproliferative disease: + $ref: + - "_terms_enum.yaml#/myelofibrosis_as_a_result_of_myeloproliferative_disease/common" + Myelofibrosis with myeloid metaplasia: + $ref: + - "_terms_enum.yaml#/myelofibrosis_with_myeloid_metaplasia/common" + Myelogenous leukemia, NOS: + $ref: + - "_terms_enum.yaml#/myelogenous_leukemia_nos/common" + Myeloid and lymphoid neoplasms with PDGFRA rearrangement: + $ref: + - "_terms_enum.yaml#/myeloid_and_lymphoid_neoplasms_with_pdgfra_rearrangement/common" + Myeloid leukemia associated with Down Syndrome: + $ref: + - "_terms_enum.yaml#/myeloid_leukemia_associated_with_down_syndrome/common" + Myeloid leukemia, NOS: + $ref: + - "_terms_enum.yaml#/myeloid_leukemia_nos/common" + Myeloid neoplasms with PDGFRB rearrangement: + $ref: + - "_terms_enum.yaml#/myeloid_neoplasms_with_pdgfrb_rearrangement/common" + Myeloid sarcoma: + $ref: + - "_terms_enum.yaml#/myeloid_sarcoma/common" + Myelolipoma: + $ref: + - "_terms_enum.yaml#/myelolipoma/common" + Myeloma, NOS: + $ref: + - "_terms_enum.yaml#/myeloma_nos/common" + Myelomatosis: + $ref: + - "_terms_enum.yaml#/myelomatosis/common" + Myeloproliferative disease, NOS: + $ref: + - "_terms_enum.yaml#/myeloproliferative_disease_nos/common" + Myeloproliferative neoplasm, NOS: + $ref: + - "_terms_enum.yaml#/myeloproliferative_neoplasm_nos/common" + Myelosclerosis with myeloid metaplasia: + $ref: + - "_terms_enum.yaml#/myelosclerosis_with_myeloid_metaplasia/common" + Myloproliferative neoplasm, unclassifiable: + $ref: + - "_terms_enum.yaml#/myloproliferative_neoplasm_unclassifiable/common" + Myoepithelial adenoma: + $ref: + - "_terms_enum.yaml#/myoepithelial_adenoma/common" + Myoepithelial carcinoma: + $ref: + - "_terms_enum.yaml#/myoepithelial_carcinoma/common" + Myoepithelial tumor: + $ref: + - "_terms_enum.yaml#/myoepithelial_tumor/common" + Myoepithelioma: + $ref: + - "_terms_enum.yaml#/myoepithelioma/common" + Myofibroblastic tumor, NOS: + $ref: + - "_terms_enum.yaml#/myofibroblastic_tumor_nos/common" + Myofibroblastoma: + $ref: + - "_terms_enum.yaml#/myofibroblastoma/common" + Myofibroma: + $ref: + - "_terms_enum.yaml#/myofibroma/common" + Myofibromatosis: + $ref: + - "_terms_enum.yaml#/myofibromatosis/common" + Myoma: + $ref: + - "_terms_enum.yaml#/myoma/common" + Myosarcoma: + $ref: + - "_terms_enum.yaml#/myosarcoma/common" + Myxofibroma, NOS: + $ref: + - "_terms_enum.yaml#/myxofibroma_nos/common" + Myxoid chondrosarcoma: + $ref: + - "_terms_enum.yaml#/myxoid_chondrosarcoma/common" + Myxoid fibroma: + $ref: + - "_terms_enum.yaml#/myxoid_fibroma/common" + Myxoid leiomyosarcoma: + $ref: + - "_terms_enum.yaml#/myxoid_leiomyosarcoma/common" + Myxoid liposarcoma: + $ref: + - "_terms_enum.yaml#/myxoid_liposarcoma/common" + Myxoinflammatory fibroblastic sarcoma (MIFS): + $ref: + - "_terms_enum.yaml#/myxoinflammatory_fibroblastic_sarcoma_mifs/common" + Myxolipoma: + $ref: + - "_terms_enum.yaml#/myxolipoma/common" + Myxoliposarcoma: + $ref: + - "_terms_enum.yaml#/myxoliposarcoma/common" + Myxoma, NOS: + $ref: + - "_terms_enum.yaml#/myxoma_nos/common" + Myxopapillary ependymoma: + $ref: + - "_terms_enum.yaml#/myxopapillary_ependymoma/common" + Myxosarcoma: + $ref: + - "_terms_enum.yaml#/myxosarcoma/common" + Neoplasm, benign: + $ref: + - "_terms_enum.yaml#/neoplasm_benign/common" + Neoplasm, malignant: + $ref: + - "_terms_enum.yaml#/neoplasm_malignant/common" + Neoplasm, malignant, uncertain whether primary or metastatic: + $ref: + - "_terms_enum.yaml#/neoplasm_malignant_uncertain_whether_primary_or_metastatic/common" + Neoplasm, metastatic: + $ref: + - "_terms_enum.yaml#/neoplasm_metastatic/common" + Neoplasm, NOS: + $ref: + - "_terms_enum.yaml#/neoplasm_nos/common" + Neoplasm, secondary: + $ref: + - "_terms_enum.yaml#/neoplasm_secondary/common" + Neoplasm, uncertain whether benign or malignant: + $ref: + - "_terms_enum.yaml#/neoplasm_uncertain_whether_benign_or_malignant/common" + Nephroblastoma, NOS: + $ref: + - "_terms_enum.yaml#/nephroblastoma_nos/common" + Nephrogenic adenofibroma: + $ref: + - "_terms_enum.yaml#/nephrogenic_adenofibroma/common" + Nephroma, NOS: + $ref: + - "_terms_enum.yaml#/nephroma_nos/common" + Nerve sheath myxoma: + $ref: + - "_terms_enum.yaml#/nerve_sheath_myxoma/common" + Nesidioblastoma: + $ref: + - "_terms_enum.yaml#/nesidioblastoma/common" + Nested urothelial carcinoma: + $ref: + - "_terms_enum.yaml#/nested_urothelial_carcinoma/common" + Neurilemoma, malignant: + $ref: + - "_terms_enum.yaml#/neurilemoma_malignant/common" + Neurilemoma, NOS: + $ref: + - "_terms_enum.yaml#/neurilemoma_nos/common" + Neurilemosarcoma: + $ref: + - "_terms_enum.yaml#/neurilemosarcoma/common" + Neurinoma: + $ref: + - "_terms_enum.yaml#/neurinoma/common" + Neurinomatosis: + $ref: + - "_terms_enum.yaml#/neurinomatosis/common" + Neuroastrocytoma: + $ref: + - "_terms_enum.yaml#/neuroastrocytoma/common" + Neuroblastoma, NOS: + $ref: + - "_terms_enum.yaml#/neuroblastoma_nos/common" + Neurocytoma: + $ref: + - "_terms_enum.yaml#/neurocytoma/common" + Neuroectodermal tumor, NOS: + $ref: + - "_terms_enum.yaml#/neuroectodermal_tumor_nos/common" + Neuroendocrine carcinoma, low grade: + $ref: + - "_terms_enum.yaml#/neuroendocrine_carcinoma_low_grade/common" + Neuroendocrine carcinoma, moderately differentiated: + $ref: + - "_terms_enum.yaml#/neuroendocrine_carcinoma_moderately_differentiated/common" + Neuroendocrine carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/neuroendocrine_carcinoma_nos/common" + Neuroendocrine carcinoma, poorly differentiated: + $ref: + - "_terms_enum.yaml#/neuroendocrine_carcinoma_poorly_differentiated/common" + Neuroendocrine carcinoma, well-differentiated: + $ref: + - "_terms_enum.yaml#/neuroendocrine_carcinoma_welldifferentiated/common" + Neuroendocrine tumor, well differentiated: + $ref: + - "_terms_enum.yaml#/neuroendocrine_tumor_well_differentiated/common" + Neuroepithelioma, NOS: + $ref: + - "_terms_enum.yaml#/neuroepithelioma_nos/common" + Neurofibroma, NOS: + $ref: + - "_terms_enum.yaml#/neurofibroma_nos/common" + Neurofibromatosis, NOS: + $ref: + - "_terms_enum.yaml#/neurofibromatosis_nos/common" + Neurofibrosarcoma: + $ref: + - "_terms_enum.yaml#/neurofibrosarcoma/common" + Neurogenic sarcoma: + $ref: + - "_terms_enum.yaml#/neurogenic_sarcoma/common" + Neurolipocytoma: + $ref: + - "_terms_enum.yaml#/neurolipocytoma/common" + Neuroma, NOS: + $ref: + - "_terms_enum.yaml#/neuroma_nos/common" + Neuronevus: + $ref: + - "_terms_enum.yaml#/neuronevus/common" + Neurosarcoma: + $ref: + - "_terms_enum.yaml#/neurosarcoma/common" + Neurothekeoma: + $ref: + - "_terms_enum.yaml#/neurothekeoma/common" + Nevus, NOS: + $ref: + - "_terms_enum.yaml#/nevus_nos/common" + NK/T-cell lymphoma, nasal and nasal-type: + $ref: + - "_terms_enum.yaml#/nktcell_lymphoma_nasal_and_nasaltype/common" + Nodal marginal zone lymphoma: + $ref: + - "_terms_enum.yaml#/nodal_marginal_zone_lymphoma/common" + Nodular hidradenoma: + $ref: + - "_terms_enum.yaml#/nodular_hidradenoma/common" + Nodular melanoma: + $ref: + - "_terms_enum.yaml#/nodular_melanoma/common" + Non-Hodgkin lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/nonhodgkin_lymphoma_nos/common" + Non-invasive EFVPTC: + $ref: + - "_terms_enum.yaml#/noninvasive_efvptc/common" + Non-invasive encapsulated follicular variant of papillary thyroid carcinoma (non-invasive EFVPTC): + $ref: + - "_terms_enum.yaml#/noninvasive_encapsulated_follicular_variant_of_papillary_thyroid_carcinoma_noninvasive_efvptc/common" + Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): + $ref: + - "_terms_enum.yaml#/noninvasive_follicular_thyroid_neoplasm_with_papillarylike_nuclear_features_niftp/common" + Non-invasive FTP: + $ref: + - "_terms_enum.yaml#/noninvasive_ftp/common" + Non-lymphocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/nonlymphocytic_leukemia_nos/common" + Non-small cell carcinoma: + $ref: + - "_terms_enum.yaml#/nonsmall_cell_carcinoma/common" + Nonchromaffin paraganglioma, malignant: + $ref: + - "_terms_enum.yaml#/nonchromaffin_paraganglioma_malignant/common" + Nonencapsulated sclerosing adenocarcinoma: + $ref: + - "_terms_enum.yaml#/nonencapsulated_sclerosing_adenocarcinoma/common" + Nonencapsulated sclerosing carcinoma: + $ref: + - "_terms_enum.yaml#/nonencapsulated_sclerosing_carcinoma/common" + Nonencapsulated sclerosing tumor: + $ref: + - "_terms_enum.yaml#/nonencapsulated_sclerosing_tumor/common" + Noninfiltrating intracystic carcinoma: + $ref: + - "_terms_enum.yaml#/noninfiltrating_intracystic_carcinoma/common" + Noninfiltrating intraductal papillary adenocarcinoma: + $ref: + - "_terms_enum.yaml#/noninfiltrating_intraductal_papillary_adenocarcinoma/common" + Noninfiltrating intraductal papillary carcinoma: + $ref: + - "_terms_enum.yaml#/noninfiltrating_intraductal_papillary_carcinoma/common" + Noninvasive pancreatobiliary papillary neoplasm with high grade dysplasia: + $ref: + - "_terms_enum.yaml#/noninvasive_pancreatobiliary_papillary_neoplasm_with_high_grade_dysplasia/common" + Noninvasive pancreatobiliary papillary neoplasm with high grade intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/noninvasive_pancreatobiliary_papillary_neoplasm_with_high_grade_intraepithelial_neoplasia/common" + Noninvasive pancreatobiliary papillary neoplasm with low grade dysplasia: + $ref: + - "_terms_enum.yaml#/noninvasive_pancreatobiliary_papillary_neoplasm_with_low_grade_dysplasia/common" + Noninvasive pancreatobiliary papillary neoplasm with low grade intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/noninvasive_pancreatobiliary_papillary_neoplasm_with_low_grade_intraepithelial_neoplasia/common" + Nonpigmented nevus: + $ref: + - "_terms_enum.yaml#/nonpigmented_nevus/common" + NUT carcinoma: + $ref: + - "_terms_enum.yaml#/nut_carcinoma/common" + NUT midline carcinoma: + $ref: + - "_terms_enum.yaml#/nut_midline_carcinoma/common" + Oat cell carcinoma: + $ref: + - "_terms_enum.yaml#/oat_cell_carcinoma/common" + Odontoameloblastoma: + $ref: + - "_terms_enum.yaml#/odontoameloblastoma/common" + Odontogenic carcinoma: + $ref: + - "_terms_enum.yaml#/odontogenic_carcinoma/common" + Odontogenic carcinosarcoma: + $ref: + - "_terms_enum.yaml#/odontogenic_carcinosarcoma/common" + Odontogenic fibroma, NOS: + $ref: + - "_terms_enum.yaml#/odontogenic_fibroma_nos/common" + Odontogenic fibrosarcoma: + $ref: + - "_terms_enum.yaml#/odontogenic_fibrosarcoma/common" + Odontogenic ghost cell tumor: + $ref: + - "_terms_enum.yaml#/odontogenic_ghost_cell_tumor/common" + Odontogenic myxofibroma: + $ref: + - "_terms_enum.yaml#/odontogenic_myxofibroma/common" + Odontogenic myxoma: + $ref: + - "_terms_enum.yaml#/odontogenic_myxoma/common" + Odontogenic sarcoma: + $ref: + - "_terms_enum.yaml#/odontogenic_sarcoma/common" + Odontogenic tumor, benign: + $ref: + - "_terms_enum.yaml#/odontogenic_tumor_benign/common" + Odontogenic tumor, malignant: + $ref: + - "_terms_enum.yaml#/odontogenic_tumor_malignant/common" + Odontogenic tumor, NOS: + $ref: + - "_terms_enum.yaml#/odontogenic_tumor_nos/common" + Odontoma, NOS: + $ref: + - "_terms_enum.yaml#/odontoma_nos/common" + Olfactory neuroblastoma: + $ref: + - "_terms_enum.yaml#/olfactory_neuroblastoma/common" + Olfactory neurocytoma: + $ref: + - "_terms_enum.yaml#/olfactory_neurocytoma/common" + Olfactory neuroepithelioma: + $ref: + - "_terms_enum.yaml#/olfactory_neuroepithelioma/common" + Olfactory neurogenic tumor: + $ref: + - "_terms_enum.yaml#/olfactory_neurogenic_tumor/common" + Oligoastrocytoma: + $ref: + - "_terms_enum.yaml#/oligoastrocytoma/common" + Oligodendroblastoma: + $ref: + - "_terms_enum.yaml#/oligodendroblastoma/common" + Oligodendroglioma, anaplastic: + $ref: + - "_terms_enum.yaml#/oligodendroglioma_anaplastic/common" + Oligodendroglioma, IDH-mutant and 1p/19q-codeleted: + $ref: + - "_terms_enum.yaml#/oligodendroglioma_idhmutant_and_1p19qcodeleted/common" + Oligodendroglioma, NOS: + $ref: + - "_terms_enum.yaml#/oligodendroglioma_nos/common" + Oncocytic adenocarcinoma: + $ref: + - "_terms_enum.yaml#/oncocytic_adenocarcinoma/common" + Oncocytic adenoma: + $ref: + - "_terms_enum.yaml#/oncocytic_adenoma/common" + Oncocytic carcinoma: + $ref: + - "_terms_enum.yaml#/oncocytic_carcinoma/common" + Oncocytic Schneiderian papilloma: + $ref: + - "_terms_enum.yaml#/oncocytic_schneiderian_papilloma/common" + Oncocytoma: + $ref: + - "_terms_enum.yaml#/oncocytoma/common" + Orchioblastoma: + $ref: + - "_terms_enum.yaml#/orchioblastoma/common" + Ossifying fibroma: + $ref: + - "_terms_enum.yaml#/ossifying_fibroma/common" + Ossifying fibromyxoid tumor: + $ref: + - "_terms_enum.yaml#/ossifying_fibromyxoid_tumor/common" + Ossifying fibromyxoid tumor, malignant: + $ref: + - "_terms_enum.yaml#/ossifying_fibromyxoid_tumor_malignant/common" + Osteoblastic sarcoma: + $ref: + - "_terms_enum.yaml#/osteoblastic_sarcoma/common" + Osteoblastoma, malignant: + $ref: + - "_terms_enum.yaml#/osteoblastoma_malignant/common" + Osteoblastoma, NOS: + $ref: + - "_terms_enum.yaml#/osteoblastoma_nos/common" + Osteocartilaginous exostosis: + $ref: + - "_terms_enum.yaml#/osteocartilaginous_exostosis/common" + Osteochondroma: + $ref: + - "_terms_enum.yaml#/osteochondroma/common" + Osteochondromatosis, NOS: + $ref: + - "_terms_enum.yaml#/osteochondromatosis_nos/common" + Osteochondrosarcoma: + $ref: + - "_terms_enum.yaml#/osteochondrosarcoma/common" + Osteofibrosarcoma: + $ref: + - "_terms_enum.yaml#/osteofibrosarcoma/common" + Osteogenic sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/osteogenic_sarcoma_nos/common" + Osteoid osteoma, NOS: + $ref: + - "_terms_enum.yaml#/osteoid_osteoma_nos/common" + Osteoma, NOS: + $ref: + - "_terms_enum.yaml#/osteoma_nos/common" + Osteosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/osteosarcoma_nos/common" + Ovarian stromal tumor: + $ref: + - "_terms_enum.yaml#/ovarian_stromal_tumor/common" + Oxyphilic adenocarcinoma: + $ref: + - "_terms_enum.yaml#/oxyphilic_adenocarcinoma/common" + Oxyphilic adenoma: + $ref: + - "_terms_enum.yaml#/oxyphilic_adenoma/common" + Pacinian tumor: + $ref: + - "_terms_enum.yaml#/pacinian_tumor/common" + Paget disease and intraductal carcinoma of breast: + $ref: + - "_terms_enum.yaml#/paget_disease_and_intraductal_carcinoma_of_breast/common" + Paget disease of breast: + $ref: + - "_terms_enum.yaml#/paget_disease_of_breast/common" + Paget disease, extramammary: + $ref: + - "_terms_enum.yaml#/paget_disease_extramammary/common" + Paget disease, mammary: + $ref: + - "_terms_enum.yaml#/paget_disease_mammary/common" + Pagetoid reticulosis: + $ref: + - "_terms_enum.yaml#/pagetoid_reticulosis/common" + Pancreatic endocrine tumor, NOS: + $ref: + - "_terms_enum.yaml#/pancreatic_endocrine_tumor_nos/common" + Pancreatoblastoma: + $ref: + - "_terms_enum.yaml#/pancreatoblastoma/common" + Papillary adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/papillary_adenocarcinoma_nos/common" + Papillary adenofibroma: + $ref: + - "_terms_enum.yaml#/papillary_adenofibroma/common" + Papillary adenoma, NOS: + $ref: + - "_terms_enum.yaml#/papillary_adenoma_nos/common" + Papillary and follicular adenocarcinoma: + $ref: + - "_terms_enum.yaml#/papillary_and_follicular_adenocarcinoma/common" + Papillary and follicular carcinoma: + $ref: + - "_terms_enum.yaml#/papillary_and_follicular_carcinoma/common" + Papillary carcinoma in situ: + $ref: + - "_terms_enum.yaml#/papillary_carcinoma_in_situ/common" + Papillary carcinoma of thyroid: + $ref: + - "_terms_enum.yaml#/papillary_carcinoma_of_thyroid/common" + Papillary carcinoma, columnar cell: + $ref: + - "_terms_enum.yaml#/papillary_carcinoma_columnar_cell/common" + Papillary carcinoma, diffuse sclerosing: + $ref: + - "_terms_enum.yaml#/papillary_carcinoma_diffuse_sclerosing/common" + Papillary carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/papillary_carcinoma_nos/common" + Papillary carcinoma, tall cell: + $ref: + - "_terms_enum.yaml#/papillary_carcinoma_tall_cell/common" + Papillary cystadenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/papillary_cystadenocarcinoma_nos/common" + Papillary cystadenoma lymphomatosum: + $ref: + - "_terms_enum.yaml#/papillary_cystadenoma_lymphomatosum/common" + Papillary cystadenoma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/papillary_cystadenoma_borderline_malignancy/common" + Papillary cystadenoma, NOS: + $ref: + - "_terms_enum.yaml#/papillary_cystadenoma_nos/common" + Papillary cystic tumor: + $ref: + - "_terms_enum.yaml#/papillary_cystic_tumor/common" + Papillary ependymoma: + $ref: + - "_terms_enum.yaml#/papillary_ependymoma/common" + Papillary epidermoid carcinoma: + $ref: + - "_terms_enum.yaml#/papillary_epidermoid_carcinoma/common" + Papillary glioneuronal tumor: + $ref: + - "_terms_enum.yaml#/papillary_glioneuronal_tumor/common" + Papillary hidradenoma: + $ref: + - "_terms_enum.yaml#/papillary_hidradenoma/common" + Papillary meningioma: + $ref: + - "_terms_enum.yaml#/papillary_meningioma/common" + Papillary mucinous cystadenocarcinoma: + $ref: + - "_terms_enum.yaml#/papillary_mucinous_cystadenocarcinoma/common" + Papillary mucinous cystadenoma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/papillary_mucinous_cystadenoma_borderline_malignancy/common" + Papillary mucinous cystadenoma, NOS: + $ref: + - "_terms_enum.yaml#/papillary_mucinous_cystadenoma_nos/common" + Papillary mucinous tumor of low malignant potential: + $ref: + - "_terms_enum.yaml#/papillary_mucinous_tumor_of_low_malignant_potential/common" + Papillary neoplasm, pancreatobiliary-type, with high grade intraepithelial neoplasia: + $ref: + - "_terms_enum.yaml#/papillary_neoplasm_pancreatobiliarytype_with_high_grade_intraepithelial_neoplasia/common" + Papillary pseudomucinous cystadenocarcinoma: + $ref: + - "_terms_enum.yaml#/papillary_pseudomucinous_cystadenocarcinoma/common" + Papillary pseudomucinous cystadenoma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/papillary_pseudomucinous_cystadenoma_borderline_malignancy/common" + Papillary pseudomucinous cystadenoma, NOS: + $ref: + - "_terms_enum.yaml#/papillary_pseudomucinous_cystadenoma_nos/common" + Papillary renal cell carcinoma: + $ref: + - "_terms_enum.yaml#/papillary_renal_cell_carcinoma/common" + Papillary serous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/papillary_serous_adenocarcinoma/common" + Papillary serous cystadenocarcinoma: + $ref: + - "_terms_enum.yaml#/papillary_serous_cystadenocarcinoma/common" + Papillary serous cystadenoma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/papillary_serous_cystadenoma_borderline_malignancy/common" + Papillary serous cystadenoma, NOS: + $ref: + - "_terms_enum.yaml#/papillary_serous_cystadenoma_nos/common" + Papillary serous tumor of low malignant potential: + $ref: + - "_terms_enum.yaml#/papillary_serous_tumor_of_low_malignant_potential/common" + Papillary squamous cell carcinoma: + $ref: + - "_terms_enum.yaml#/papillary_squamous_cell_carcinoma/common" + Papillary squamous cell carcinoma in situ: + $ref: + - "_terms_enum.yaml#/papillary_squamous_cell_carcinoma_in_situ/common" + Papillary squamous cell carcinoma, non-invasive: + $ref: + - "_terms_enum.yaml#/papillary_squamous_cell_carcinoma_noninvasive/common" + Papillary syringadenoma: + $ref: + - "_terms_enum.yaml#/papillary_syringadenoma/common" + Papillary syringocystadenoma: + $ref: + - "_terms_enum.yaml#/papillary_syringocystadenoma/common" + Papillary transitional cell carcinoma: + $ref: + - "_terms_enum.yaml#/papillary_transitional_cell_carcinoma/common" + Papillary transitional cell carcinoma, non-invasive: + $ref: + - "_terms_enum.yaml#/papillary_transitional_cell_carcinoma_noninvasive/common" + Papillary transitional cell neoplasm of low malignant potential: + $ref: + - "_terms_enum.yaml#/papillary_transitional_cell_neoplasm_of_low_malignant_potential/common" + Papillary tumor of the pineal region: + $ref: + - "_terms_enum.yaml#/papillary_tumor_of_the_pineal_region/common" + Papillary urothelial carcinoma: + $ref: + - "_terms_enum.yaml#/papillary_urothelial_carcinoma/common" + Papillary urothelial carcinoma, non-invasive: + $ref: + - "_terms_enum.yaml#/papillary_urothelial_carcinoma_noninvasive/common" + Papillary urothelial neoplasm of low malignant potential: + $ref: + - "_terms_enum.yaml#/papillary_urothelial_neoplasm_of_low_malignant_potential/common" + Papillocystic adenocarcinoma: + $ref: + - "_terms_enum.yaml#/papillocystic_adenocarcinoma/common" + Papilloma of bladder: + $ref: + - "_terms_enum.yaml#/papilloma_of_bladder/common" + Papilloma, NOS: + $ref: + - "_terms_enum.yaml#/papilloma_nos/common" + Papillomatosis, glandular: + $ref: + - "_terms_enum.yaml#/papillomatosis_glandular/common" + Papillomatosis, NOS: + $ref: + - "_terms_enum.yaml#/papillomatosis_nos/common" + Papillotubular adenoma: + $ref: + - "_terms_enum.yaml#/papillotubular_adenoma/common" + Parachordoma: + $ref: + - "_terms_enum.yaml#/parachordoma/common" + Parafollicular cell carcinoma: + $ref: + - "_terms_enum.yaml#/parafollicular_cell_carcinoma/common" + Paraganglioma, benign: + $ref: + - "_terms_enum.yaml#/paraganglioma_benign/common" + Paraganglioma, malignant: + $ref: + - "_terms_enum.yaml#/paraganglioma_malignant/common" + Paraganglioma, NOS: + $ref: + - "_terms_enum.yaml#/paraganglioma_nos/common" + Parasympathetic paraganglioma: + $ref: + - "_terms_enum.yaml#/parasympathetic_paraganglioma/common" + Parietal cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/parietal_cell_adenocarcinoma/common" + Parietal cell carcinoma: + $ref: + - "_terms_enum.yaml#/parietal_cell_carcinoma/common" + Parosteal osteosarcoma: + $ref: + - "_terms_enum.yaml#/parosteal_osteosarcoma/common" + Partial hydatidiform mole: + $ref: + - "_terms_enum.yaml#/partial_hydatidiform_mole/common" + PEComa, malignant: + $ref: + - "_terms_enum.yaml#/pecoma_malignant/common" + Periapical cemental dysplasia: + $ref: + - "_terms_enum.yaml#/periapical_cemental_dysplasia/common" + Periapical cemento-osseous dysplasia: + $ref: + - "_terms_enum.yaml#/periapical_cementoosseous_dysplasia/common" + Pericanalicular fibroadenoma: + $ref: + - "_terms_enum.yaml#/pericanalicular_fibroadenoma/common" + Perifollicular fibroma: + $ref: + - "_terms_enum.yaml#/perifollicular_fibroma/common" + Perineural MPNST: + $ref: + - "_terms_enum.yaml#/perineural_mpnst/common" + Perineurioma, malignant: + $ref: + - "_terms_enum.yaml#/perineurioma_malignant/common" + Perineurioma, NOS: + $ref: + - "_terms_enum.yaml#/perineurioma_nos/common" + Periosteal chondroma: + $ref: + - "_terms_enum.yaml#/periosteal_chondroma/common" + Periosteal chondrosarcoma: + $ref: + - "_terms_enum.yaml#/periosteal_chondrosarcoma/common" + Periosteal fibroma: + $ref: + - "_terms_enum.yaml#/periosteal_fibroma/common" + Periosteal fibrosarcoma: + $ref: + - "_terms_enum.yaml#/periosteal_fibrosarcoma/common" + Periosteal osteosarcoma: + $ref: + - "_terms_enum.yaml#/periosteal_osteosarcoma/common" + Peripheral neuroectodermal tumor: + $ref: + - "_terms_enum.yaml#/peripheral_neuroectodermal_tumor/common" + Peripheral odontogenic fibroma: + $ref: + - "_terms_enum.yaml#/peripheral_odontogenic_fibroma/common" + Peripheral primitive neuroectodermal tumor, NOS: + $ref: + - "_terms_enum.yaml#/peripheral_primitive_neuroectodermal_tumor_nos/common" + Peripheral T-cell lymphoma, AILD (Angioimmunoblastic Lymphadenopathy with Dysproteinemia): + $ref: + - "_terms_enum.yaml#/peripheral_tcell_lymphoma_aild_angioimmunoblastic_lymphadenopathy_with_dysproteinemia/common" + Peripheral T-cell lymphoma, large cell: + $ref: + - "_terms_enum.yaml#/peripheral_tcell_lymphoma_large_cell/common" + Peripheral T-cell lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/peripheral_tcell_lymphoma_nos/common" + Perivascular epithelioid cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/perivascular_epithelioid_cell_tumor_malignant/common" + Pheochromoblastoma: + $ref: + - "_terms_enum.yaml#/pheochromoblastoma/common" + Pheochromocytoma, malignant: + $ref: + - "_terms_enum.yaml#/pheochromocytoma_malignant/common" + Pheochromocytoma, NOS: + $ref: + - "_terms_enum.yaml#/pheochromocytoma_nos/common" + Phosphaturic mesenchymal tumor, malignant: + $ref: + - "_terms_enum.yaml#/phosphaturic_mesenchymal_tumor_malignant/common" + Phyllodes tumor, benign: + $ref: + - "_terms_enum.yaml#/phyllodes_tumor_benign/common" + Phyllodes tumor, borderline: + $ref: + - "_terms_enum.yaml#/phyllodes_tumor_borderline/common" + Phyllodes tumor, malignant: + $ref: + - "_terms_enum.yaml#/phyllodes_tumor_malignant/common" + Phyllodes tumor, NOS: + $ref: + - "_terms_enum.yaml#/phyllodes_tumor_nos/common" + Pick tubular adenoma: + $ref: + - "_terms_enum.yaml#/pick_tubular_adenoma/common" + Pigmented adenoma: + $ref: + - "_terms_enum.yaml#/pigmented_adenoma/common" + Pigmented basal cell carcinoma: + $ref: + - "_terms_enum.yaml#/pigmented_basal_cell_carcinoma/common" + Pigmented dermatofibrosarcoma protuberans: + $ref: + - "_terms_enum.yaml#/pigmented_dermatofibrosarcoma_protuberans/common" + Pigmented nevus, NOS: + $ref: + - "_terms_enum.yaml#/pigmented_nevus_nos/common" + Pigmented schwannoma: + $ref: + - "_terms_enum.yaml#/pigmented_schwannoma/common" + Pigmented spindle cell nevus of Reed: + $ref: + - "_terms_enum.yaml#/pigmented_spindle_cell_nevus_of_reed/common" + Pilar tumor: + $ref: + - "_terms_enum.yaml#/pilar_tumor/common" + Pilocytic astrocytoma: + $ref: + - "_terms_enum.yaml#/pilocytic_astrocytoma/common" + Piloid astrocytoma: + $ref: + - "_terms_enum.yaml#/piloid_astrocytoma/common" + Pilomatricoma, malignant: + $ref: + - "_terms_enum.yaml#/pilomatricoma_malignant/common" + Pilomatricoma, NOS: + $ref: + - "_terms_enum.yaml#/pilomatricoma_nos/common" + Pilomatrix carcinoma: + $ref: + - "_terms_enum.yaml#/pilomatrix_carcinoma/common" + Pilomatrixoma, malignant: + $ref: + - "_terms_enum.yaml#/pilomatrixoma_malignant/common" + Pilomatrixoma, NOS: + $ref: + - "_terms_enum.yaml#/pilomatrixoma_nos/common" + Pilomyxoid astrocytoma: + $ref: + - "_terms_enum.yaml#/pilomyxoid_astrocytoma/common" + PIN III: + $ref: + - "_terms_enum.yaml#/pin_iii/common" + Pindborg tumor: + $ref: + - "_terms_enum.yaml#/pindborg_tumor/common" + Pineal parenchymal tumor of intermediate differentiation: + $ref: + - "_terms_enum.yaml#/pineal_parenchymal_tumor_of_intermediate_differentiation/common" + Pinealoma: + $ref: + - "_terms_enum.yaml#/pinealoma/common" + Pineoblastoma: + $ref: + - "_terms_enum.yaml#/pineoblastoma/common" + Pineocytoma: + $ref: + - "_terms_enum.yaml#/pineocytoma/common" + Pinkus tumor: + $ref: + - "_terms_enum.yaml#/pinkus_tumor/common" + Pituicytoma: + $ref: + - "_terms_enum.yaml#/pituicytoma/common" + Pituitary adenoma, NOS: + $ref: + - "_terms_enum.yaml#/pituitary_adenoma_nos/common" + Pituitary carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/pituitary_carcinoma_nos/common" + Placental site trophoblastic tumor: + $ref: + - "_terms_enum.yaml#/placental_site_trophoblastic_tumor/common" + Plasma cell leukemia: + $ref: + - "_terms_enum.yaml#/plasma_cell_leukemia/common" + Plasma cell myeloma: + $ref: + - "_terms_enum.yaml#/plasma_cell_myeloma/common" + Plasma cell tumor: + $ref: + - "_terms_enum.yaml#/plasma_cell_tumor/common" + Plasmablastic lymphoma: + $ref: + - "_terms_enum.yaml#/plasmablastic_lymphoma/common" + Plasmacytic leukemia: + $ref: + - "_terms_enum.yaml#/plasmacytic_leukemia/common" + Plasmacytic lymphoma: + $ref: + - "_terms_enum.yaml#/plasmacytic_lymphoma/common" + Plasmacytoma of bone: + $ref: + - "_terms_enum.yaml#/plasmacytoma_of_bone/common" + Plasmacytoma, extramedullary: + $ref: + - "_terms_enum.yaml#/plasmacytoma_extramedullary/common" + Plasmacytoma, NOS: + $ref: + - "_terms_enum.yaml#/plasmacytoma_nos/common" + Pleomorphic adenoma: + $ref: + - "_terms_enum.yaml#/pleomorphic_adenoma/common" + Pleomorphic carcinoma: + $ref: + - "_terms_enum.yaml#/pleomorphic_carcinoma/common" + Pleomorphic cell sarcoma: + $ref: + - "_terms_enum.yaml#/pleomorphic_cell_sarcoma/common" + Pleomorphic leiomyoma: + $ref: + - "_terms_enum.yaml#/pleomorphic_leiomyoma/common" + Pleomorphic lipoma: + $ref: + - "_terms_enum.yaml#/pleomorphic_lipoma/common" + Pleomorphic liposarcoma: + $ref: + - "_terms_enum.yaml#/pleomorphic_liposarcoma/common" + Pleomorphic lobular carcinoma: + $ref: + - "_terms_enum.yaml#/pleomorphic_lobular_carcinoma/common" + Pleomorphic lobular carcinoma in situ: + $ref: + - "_terms_enum.yaml#/pleomorphic_lobular_carcinoma_in_situ/common" + Pleomorphic rhabdomyosarcoma, adult type: + $ref: + - "_terms_enum.yaml#/pleomorphic_rhabdomyosarcoma_adult_type/common" + Pleomorphic rhabdomyosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/pleomorphic_rhabdomyosarcoma_nos/common" + Pleomorphic xanthoastrocytoma: + $ref: + - "_terms_enum.yaml#/pleomorphic_xanthoastrocytoma/common" + Pleuropulmonary blastoma: + $ref: + - "_terms_enum.yaml#/pleuropulmonary_blastoma/common" + Plexiform fibrohistiocytic tumor: + $ref: + - "_terms_enum.yaml#/plexiform_fibrohistiocytic_tumor/common" + Plexiform hemangioma: + $ref: + - "_terms_enum.yaml#/plexiform_hemangioma/common" + Plexiform neurofibroma: + $ref: + - "_terms_enum.yaml#/plexiform_neurofibroma/common" + Plexiform neuroma: + $ref: + - "_terms_enum.yaml#/plexiform_neuroma/common" + Plexiform schwannoma: + $ref: + - "_terms_enum.yaml#/plexiform_schwannoma/common" + PNET, NOS: + $ref: + - "_terms_enum.yaml#/pnet_nos/common" + Pneumoblastoma: + $ref: + - "_terms_enum.yaml#/pneumoblastoma/common" + Polar spongioblastoma: + $ref: + - "_terms_enum.yaml#/polar_spongioblastoma/common" + Polycythemia rubra vera: + $ref: + - "_terms_enum.yaml#/polycythemia_rubra_vera/common" + Polycythemia vera: + $ref: + - "_terms_enum.yaml#/polycythemia_vera/common" + Polygonal cell carcinoma: + $ref: + - "_terms_enum.yaml#/polygonal_cell_carcinoma/common" + Polymorphic post transplant lymphoproliferative disorder: + $ref: + - "_terms_enum.yaml#/polymorphic_post_transplant_lymphoproliferative_disorder/common" + Polypoid adenoma: + $ref: + - "_terms_enum.yaml#/polypoid_adenoma/common" + Polyvesicular vitelline tumor: + $ref: + - "_terms_enum.yaml#/polyvesicular_vitelline_tumor/common" + Poorly cohesive carcinoma: + $ref: + - "_terms_enum.yaml#/poorly_cohesive_carcinoma/common" + Porocarcinoma: + $ref: + - "_terms_enum.yaml#/porocarcinoma/common" + Post transplant lymphoproliferative disorder, NOS: + $ref: + - "_terms_enum.yaml#/post_transplant_lymphoproliferative_disorder_nos/common" + PPNET: + $ref: + - "_terms_enum.yaml#/ppnet/common" + Pre-B ALL: + $ref: + - "_terms_enum.yaml#/preb_all/common" + Pre-pre-B ALL: + $ref: + - "_terms_enum.yaml#/prepreb_all/common" + Pre-T ALL: + $ref: + - "_terms_enum.yaml#/pret_all/common" + Precancerous melanosis, NOS: + $ref: + - "_terms_enum.yaml#/precancerous_melanosis_nos/common" + Precursor B-cell lymphoblastic leukemia: + $ref: + - "_terms_enum.yaml#/precursor_bcell_lymphoblastic_leukemia/common" + Precursor B-cell lymphoblastic lymphoma: + $ref: + - "_terms_enum.yaml#/precursor_bcell_lymphoblastic_lymphoma/common" + Precursor cell lymphoblastic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/precursor_cell_lymphoblastic_leukemia_nos/common" + Precursor cell lymphoblastic leukemia, not phenotyped: + $ref: + - "_terms_enum.yaml#/precursor_cell_lymphoblastic_leukemia_not_phenotyped/common" + Precursor cell lymphoblastic lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/precursor_cell_lymphoblastic_lymphoma_nos/common" + Precursor T-cell lymphoblastic leukemia: + $ref: + - "_terms_enum.yaml#/precursor_tcell_lymphoblastic_leukemia/common" + Precursor T-cell lymphoblastic lymphoma: + $ref: + - "_terms_enum.yaml#/precursor_tcell_lymphoblastic_lymphoma/common" + Preleukemia: + $ref: + - "_terms_enum.yaml#/preleukemia/common" + Preleukemic syndrome: + $ref: + - "_terms_enum.yaml#/preleukemic_syndrome/common" + Primary amyloidosis: + $ref: + - "_terms_enum.yaml#/primary_amyloidosis/common" + Primary cutaneous anaplastic large cell lymphoma: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_anaplastic_large_cell_lymphoma/common" + Primary cutaneous CD4-positive small/medium T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_cd4positive_smallmedium_tcell_lymphoma/common" + Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_cd8positive_aggressive_epidermotropic_cytotoxic_tcell_lymphoma/common" + Primary cutaneous CD30+ large T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_cd30_large_tcell_lymphoma/common" + Primary cutaneous CD30+ T-cell lymphoproliferative disorder: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_cd30_tcell_lymphoproliferative_disorder/common" + Primary cutaneous DLBCL, leg type: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_dlbcl_leg_type/common" + Primary cutaneous follicle centre lymphoma: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_follicle_centre_lymphoma/common" + Primary cutaneous gamma-delta T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_gammadelta_tcell_lymphoma/common" + Primary cutaneous neuroendocrine carcinoma: + $ref: + - "_terms_enum.yaml#/primary_cutaneous_neuroendocrine_carcinoma/common" + Primary effusion lymphoma: + $ref: + - "_terms_enum.yaml#/primary_effusion_lymphoma/common" + Primary myelofibrosis: + $ref: + - "_terms_enum.yaml#/primary_myelofibrosis/common" + Primary serous papillary carcinoma of peritoneum: + $ref: + - "_terms_enum.yaml#/primary_serous_papillary_carcinoma_of_peritoneum/common" + Primitive neuroectodermal tumor, NOS: + $ref: + - "_terms_enum.yaml#/primitive_neuroectodermal_tumor_nos/common" + Pro-B ALL: + $ref: + - "_terms_enum.yaml#/prob_all/common" + Pro-T ALL: + $ref: + - "_terms_enum.yaml#/prot_all/common" + Prolactinoma: + $ref: + - "_terms_enum.yaml#/prolactinoma/common" + Proliferating trichilemmal cyst: + $ref: + - "_terms_enum.yaml#/proliferating_trichilemmal_cyst/common" + Proliferating trichilemmal tumor: + $ref: + - "_terms_enum.yaml#/proliferating_trichilemmal_tumor/common" + Proliferative dermal lesion in congenital nevus: + $ref: + - "_terms_enum.yaml#/proliferative_dermal_lesion_in_congenital_nevus/common" + Proliferative polycythemia: + $ref: + - "_terms_enum.yaml#/proliferative_polycythemia/common" + Prolymphocytic leukemia, B-cell type: + $ref: + - "_terms_enum.yaml#/prolymphocytic_leukemia_bcell_type/common" + Prolymphocytic leukemia, NOS: + $ref: + - "_terms_enum.yaml#/prolymphocytic_leukemia_nos/common" + Prolymphocytic leukemia, T-cell type: + $ref: + - "_terms_enum.yaml#/prolymphocytic_leukemia_tcell_type/common" + Prostatic intraepithelial neoplasia, grade III: + $ref: + - "_terms_enum.yaml#/prostatic_intraepithelial_neoplasia_grade_iii/common" + Protoplasmic astrocytoma: + $ref: + - "_terms_enum.yaml#/protoplasmic_astrocytoma/common" + Psammomatous meningioma: + $ref: + - "_terms_enum.yaml#/psammomatous_meningioma/common" + Psammomatous schwannoma: + $ref: + - "_terms_enum.yaml#/psammomatous_schwannoma/common" + Pseudomucinous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/pseudomucinous_adenocarcinoma/common" + Pseudomucinous cystadenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/pseudomucinous_cystadenocarcinoma_nos/common" + Pseudomucinous cystadenoma, NOS: + $ref: + - "_terms_enum.yaml#/pseudomucinous_cystadenoma_nos/common" + Pseudomyxoma peritonei: + $ref: + - "_terms_enum.yaml#/pseudomyxoma_peritonei/common" + Pseudomyxoma peritonei with unknown primary site: + $ref: + - "_terms_enum.yaml#/pseudomyxoma_peritonei_with_unknown_primary_site/common" + Pseudosarcomatous carcinoma: + $ref: + - "_terms_enum.yaml#/pseudosarcomatous_carcinoma/common" + PTLD, NOS: + $ref: + - "_terms_enum.yaml#/ptld_nos/common" + Pulmonary adenomatosis: + $ref: + - "_terms_enum.yaml#/pulmonary_adenomatosis/common" + Pulmonary artery intimal sarcoma: + $ref: + - "_terms_enum.yaml#/pulmonary_artery_intimal_sarcoma/common" + Pulmonary blastoma: + $ref: + - "_terms_enum.yaml#/pulmonary_blastoma/common" + Pulmonary myxoid sarcoma with EWSR1-CREB1 translocation: + $ref: + - "_terms_enum.yaml#/pulmonary_myxoid_sarcoma_with_ewsr1creb1_translocation/common" + Queyrat erythroplasia: + $ref: + - "_terms_enum.yaml#/queyrat_erythroplasia/common" + Racemose hemangioma: + $ref: + - "_terms_enum.yaml#/racemose_hemangioma/common" + RAEB: + $ref: + - "_terms_enum.yaml#/raeb/common" + RAEB I: + $ref: + - "_terms_enum.yaml#/raeb_i/common" + RAEB II: + $ref: + - "_terms_enum.yaml#/raeb_ii/common" + RAEB-T: + $ref: + - "_terms_enum.yaml#/raebt/common" + RARS: + $ref: + - "_terms_enum.yaml#/rars/common" + Rathke pouch tumor: + $ref: + - "_terms_enum.yaml#/rathke_pouch_tumor/common" + Recklinghausen disease: + $ref: + - "_terms_enum.yaml#/recklinghausen_disease/common" + Refractory anemia: + $ref: + - "_terms_enum.yaml#/refractory_anemia/common" + Refractory anemia with excess blasts: + $ref: + - "_terms_enum.yaml#/refractory_anemia_with_excess_blasts/common" + Refractory anemia with excess blasts in transformation: + $ref: + - "_terms_enum.yaml#/refractory_anemia_with_excess_blasts_in_transformation/common" + Refractory anemia with ring sideroblasts associated with marked thrombocytosis: + $ref: + - "_terms_enum.yaml#/refractory_anemia_with_ring_sideroblasts_associated_with_marked_thrombocytosis/common" + Refractory anemia with ringed sideroblasts: + $ref: + - "_terms_enum.yaml#/refractory_anemia_with_ringed_sideroblasts/common" + Refractory anemia with sideroblasts: + $ref: + - "_terms_enum.yaml#/refractory_anemia_with_sideroblasts/common" + Refractory cytopenia of childhood: + $ref: + - "_terms_enum.yaml#/refractory_cytopenia_of_childhood/common" + Refractory cytopenia with multilineage dysplasia: + $ref: + - "_terms_enum.yaml#/refractory_cytopenia_with_multilineage_dysplasia/common" + Refractory neutropenia: + $ref: + - "_terms_enum.yaml#/refractory_neutropenia/common" + Refractory thrombocytopenia: + $ref: + - "_terms_enum.yaml#/refractory_thrombocytopenia/common" + Regressing nevus: + $ref: + - "_terms_enum.yaml#/regressing_nevus/common" + Renal carcinoma, collecting duct type: + $ref: + - "_terms_enum.yaml#/renal_carcinoma_collecting_duct_type/common" + Renal cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/renal_cell_adenocarcinoma/common" + Renal cell carcinoma, chromophobe type: + $ref: + - "_terms_enum.yaml#/renal_cell_carcinoma_chromophobe_type/common" + Renal cell carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/renal_cell_carcinoma_nos/common" + Renal cell carcinoma, sarcomatoid: + $ref: + - "_terms_enum.yaml#/renal_cell_carcinoma_sarcomatoid/common" + Renal cell carcinoma, spindle cell: + $ref: + - "_terms_enum.yaml#/renal_cell_carcinoma_spindle_cell/common" + Renal cell carcinoma, unclassified: + $ref: + - "_terms_enum.yaml#/renal_cell_carcinoma_unclassified/common" + Renal medullary carcinoma: + $ref: + - "_terms_enum.yaml#/renal_medullary_carcinoma/common" + Reninoma: + $ref: + - "_terms_enum.yaml#/reninoma/common" + Reserve cell carcinoma: + $ref: + - "_terms_enum.yaml#/reserve_cell_carcinoma/common" + Reticulohistiocytoma: + $ref: + - "_terms_enum.yaml#/reticulohistiocytoma/common" + Reticulosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/reticulosarcoma_nos/common" + Reticulum cell sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/reticulum_cell_sarcoma_nos/common" + Retinal anlage tumor: + $ref: + - "_terms_enum.yaml#/retinal_anlage_tumor/common" + Retinoblastoma, differentiated: + $ref: + - "_terms_enum.yaml#/retinoblastoma_differentiated/common" + Retinoblastoma, diffuse: + $ref: + - "_terms_enum.yaml#/retinoblastoma_diffuse/common" + Retinoblastoma, NOS: + $ref: + - "_terms_enum.yaml#/retinoblastoma_nos/common" + Retinoblastoma, spontaneously regressed: + $ref: + - "_terms_enum.yaml#/retinoblastoma_spontaneously_regressed/common" + Retinoblastoma, undifferentiated: + $ref: + - "_terms_enum.yaml#/retinoblastoma_undifferentiated/common" + Retinocytoma: + $ref: + - "_terms_enum.yaml#/retinocytoma/common" + Retroperitoneal fibromatosis: + $ref: + - "_terms_enum.yaml#/retroperitoneal_fibromatosis/common" + Rhabdoid meningioma: + $ref: + - "_terms_enum.yaml#/rhabdoid_meningioma/common" + Rhabdoid sarcoma: + $ref: + - "_terms_enum.yaml#/rhabdoid_sarcoma/common" + Rhabdoid tumor, NOS: + $ref: + - "_terms_enum.yaml#/rhabdoid_tumor_nos/common" + Rhabdomyoma, NOS: + $ref: + - "_terms_enum.yaml#/rhabdomyoma_nos/common" + Rhabdomyosarcoma with ganglionic differentiation: + $ref: + - "_terms_enum.yaml#/rhabdomyosarcoma_with_ganglionic_differentiation/common" + Rhabdomyosarcoma, NOS: + $ref: + - "_terms_enum.yaml#/rhabdomyosarcoma_nos/common" + Rhabdosarcoma: + $ref: + - "_terms_enum.yaml#/rhabdosarcoma/common" + Rodent ulcer: + $ref: + - "_terms_enum.yaml#/rodent_ulcer/common" + Rosette-forming glioneuronal tumor: + $ref: + - "_terms_enum.yaml#/rosetteforming_glioneuronal_tumor/common" + Round cell carcinoma: + $ref: + - "_terms_enum.yaml#/round_cell_carcinoma/common" + Round cell liposarcoma: + $ref: + - "_terms_enum.yaml#/round_cell_liposarcoma/common" + Round cell osteosarcoma: + $ref: + - "_terms_enum.yaml#/round_cell_osteosarcoma/common" + Salivary duct carcinoma: + $ref: + - "_terms_enum.yaml#/salivary_duct_carcinoma/common" + SALT lymphoma: + $ref: + - "_terms_enum.yaml#/salt_lymphoma/common" + Sarcoma botryoides: + $ref: + - "_terms_enum.yaml#/sarcoma_botryoides/common" + Sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/sarcoma_nos/common" + Sarcomatoid carcinoma: + $ref: + - "_terms_enum.yaml#/sarcomatoid_carcinoma/common" + Sarcomatoid mesothelioma: + $ref: + - "_terms_enum.yaml#/sarcomatoid_mesothelioma/common" + Sarcomatosis, NOS: + $ref: + - "_terms_enum.yaml#/sarcomatosis_nos/common" + Schmincke tumor: + $ref: + - "_terms_enum.yaml#/schmincke_tumor/common" + Schneiderian carcinoma: + $ref: + - "_terms_enum.yaml#/schneiderian_carcinoma/common" + Schneiderian papilloma, inverted: + $ref: + - "_terms_enum.yaml#/schneiderian_papilloma_inverted/common" + Schneiderian papilloma, NOS: + $ref: + - "_terms_enum.yaml#/schneiderian_papilloma_nos/common" + Schwannoma, NOS: + $ref: + - "_terms_enum.yaml#/schwannoma_nos/common" + Scirrhous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/scirrhous_adenocarcinoma/common" + Scirrhous carcinoma: + $ref: + - "_terms_enum.yaml#/scirrhous_carcinoma/common" + Sclerosing epithelioid fibrosarcoma: + $ref: + - "_terms_enum.yaml#/sclerosing_epithelioid_fibrosarcoma/common" + Sclerosing hemangioma: + $ref: + - "_terms_enum.yaml#/sclerosing_hemangioma/common" + Sclerosing hepatic carcinoma: + $ref: + - "_terms_enum.yaml#/sclerosing_hepatic_carcinoma/common" + Sclerosing liposarcoma: + $ref: + - "_terms_enum.yaml#/sclerosing_liposarcoma/common" + Sclerosing rhabdomyosarcoma: + $ref: + - "_terms_enum.yaml#/sclerosing_rhabdomyosarcoma/common" + Sclerosing stromal tumor: + $ref: + - "_terms_enum.yaml#/sclerosing_stromal_tumor/common" + Sclerosing sweat duct carcinoma: + $ref: + - "_terms_enum.yaml#/sclerosing_sweat_duct_carcinoma/common" + Sebaceous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/sebaceous_adenocarcinoma/common" + Sebaceous adenoma: + $ref: + - "_terms_enum.yaml#/sebaceous_adenoma/common" + Sebaceous carcinoma: + $ref: + - "_terms_enum.yaml#/sebaceous_carcinoma/common" + Sebaceous epithelioma: + $ref: + - "_terms_enum.yaml#/sebaceous_epithelioma/common" + Secondary carcinoma: + $ref: + - "_terms_enum.yaml#/secondary_carcinoma/common" + Secretory carcinoma of breast: + $ref: + - "_terms_enum.yaml#/secretory_carcinoma_of_breast/common" + Secretory meningioma: + $ref: + - "_terms_enum.yaml#/secretory_meningioma/common" + Seminoma with high mitotic index: + $ref: + - "_terms_enum.yaml#/seminoma_with_high_mitotic_index/common" + Seminoma, anaplastic: + $ref: + - "_terms_enum.yaml#/seminoma_anaplastic/common" + Seminoma, NOS: + $ref: + - "_terms_enum.yaml#/seminoma_nos/common" + Seromucinous carcinoma: + $ref: + - "_terms_enum.yaml#/seromucinous_carcinoma/common" + Serous adenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/serous_adenocarcinoma_nos/common" + Serous adenofibroma, NOS: + $ref: + - "_terms_enum.yaml#/serous_adenofibroma_nos/common" + Serous borderline tumor-micropapillary variant: + $ref: + - "_terms_enum.yaml#/serous_borderline_tumormicropapillary_variant/common" + Serous carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/serous_carcinoma_nos/common" + Serous cystadenocarcinoma, NOS: + $ref: + - "_terms_enum.yaml#/serous_cystadenocarcinoma_nos/common" + Serous cystadenoma, borderline malignancy: + $ref: + - "_terms_enum.yaml#/serous_cystadenoma_borderline_malignancy/common" + Serous cystadenoma, NOS: + $ref: + - "_terms_enum.yaml#/serous_cystadenoma_nos/common" + Serous cystoma: + $ref: + - "_terms_enum.yaml#/serous_cystoma/common" + Serous endometrial intraepithelial carcinoma: + $ref: + - "_terms_enum.yaml#/serous_endometrial_intraepithelial_carcinoma/common" + Serous microcystic adenoma: + $ref: + - "_terms_enum.yaml#/serous_microcystic_adenoma/common" + Serous papillary cystic tumor of borderline malignancy: + $ref: + - "_terms_enum.yaml#/serous_papillary_cystic_tumor_of_borderline_malignancy/common" + Serous surface papillary carcinoma: + $ref: + - "_terms_enum.yaml#/serous_surface_papillary_carcinoma/common" + Serous surface papilloma: + $ref: + - "_terms_enum.yaml#/serous_surface_papilloma/common" + Serous tubal intraepithelial carcinoma: + $ref: + - "_terms_enum.yaml#/serous_tubal_intraepithelial_carcinoma/common" + Serous tumor, NOS, of low malignant potential: + $ref: + - "_terms_enum.yaml#/serous_tumor_nos_of_low_malignant_potential/common" + Serrated adenoma: + $ref: + - "_terms_enum.yaml#/serrated_adenoma/common" + Sertoli cell adenoma: + $ref: + - "_terms_enum.yaml#/sertoli_cell_adenoma/common" + Sertoli cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/sertoli_cell_tumor_nos/common" + Sertoli-Leydig cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/sertolileydig_cell_tumor_nos/common" + Sessile serrated adenoma: + $ref: + - "_terms_enum.yaml#/sessile_serrated_adenoma/common" + Sessile serrated polyp: + $ref: + - "_terms_enum.yaml#/sessile_serrated_polyp/common" + SETTLE: + $ref: + - "_terms_enum.yaml#/settle/common" + Sex cord tumor, NOS: + $ref: + - "_terms_enum.yaml#/sex_cord_tumor_nos/common" + Sex cord-gonadal stromal tumor, incompletely differentiated: + $ref: + - "_terms_enum.yaml#/sex_cordgonadal_stromal_tumor_incompletely_differentiated/common" + Sex cord-gonadal stromal tumor, mixed forms: + $ref: + - "_terms_enum.yaml#/sex_cordgonadal_stromal_tumor_mixed_forms/common" + Sex cord-gonadal stromal tumor, NOS: + $ref: + - "_terms_enum.yaml#/sex_cordgonadal_stromal_tumor_nos/common" + Sezary disease: + $ref: + - "_terms_enum.yaml#/sezary_disease/common" + Sezary syndrome: + $ref: + - "_terms_enum.yaml#/sezary_syndrome/common" + Signet ring cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/signet_ring_cell_adenocarcinoma/common" + Signet ring cell carcinoma: + $ref: + - "_terms_enum.yaml#/signet_ring_cell_carcinoma/common" + Sinonasal papilloma, exophytic: + $ref: + - "_terms_enum.yaml#/sinonasal_papilloma_exophytic/common" + Sinonasal papilloma, fungiform: + $ref: + - "_terms_enum.yaml#/sinonasal_papilloma_fungiform/common" + Sinonasal papilloma, NOS: + $ref: + - "_terms_enum.yaml#/sinonasal_papilloma_nos/common" + Skin appendage adenoma: + $ref: + - "_terms_enum.yaml#/skin_appendage_adenoma/common" + Skin appendage carcinoma: + $ref: + - "_terms_enum.yaml#/skin_appendage_carcinoma/common" + Skin appendage tumor, benign: + $ref: + - "_terms_enum.yaml#/skin_appendage_tumor_benign/common" + Skin-associated lymphoid tissue lymphoma: + $ref: + - "_terms_enum.yaml#/skinassociated_lymphoid_tissue_lymphoma/common" + Small cell carcinoma pulmonary type: + $ref: + - "_terms_enum.yaml#/small_cell_carcinoma_pulmonary_type/common" + Small cell carcinoma, fusiform cell: + $ref: + - "_terms_enum.yaml#/small_cell_carcinoma_fusiform_cell/common" + Small cell carcinoma, hypercalcemic type: + $ref: + - "_terms_enum.yaml#/small_cell_carcinoma_hypercalcemic_type/common" + Small cell carcinoma, intermediate cell: + $ref: + - "_terms_enum.yaml#/small_cell_carcinoma_intermediate_cell/common" + Small cell carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/small_cell_carcinoma_nos/common" + Small cell neuroendocrine carcinoma: + $ref: + - "_terms_enum.yaml#/small_cell_neuroendocrine_carcinoma/common" + Small cell osteosarcoma: + $ref: + - "_terms_enum.yaml#/small_cell_osteosarcoma/common" + Small cell sarcoma: + $ref: + - "_terms_enum.yaml#/small_cell_sarcoma/common" + Smooth muscle tumor of uncertain malignant potential: + $ref: + - "_terms_enum.yaml#/smooth_muscle_tumor_of_uncertain_malignant_potential/common" + Smooth muscle tumor, NOS: + $ref: + - "_terms_enum.yaml#/smooth_muscle_tumor_nos/common" + Soft tissue perineurioma: + $ref: + - "_terms_enum.yaml#/soft_tissue_perineurioma/common" + Soft tissue sarcoma: + $ref: + - "_terms_enum.yaml#/soft_tissue_sarcoma/common" + Soft tissue tumor, benign: + $ref: + - "_terms_enum.yaml#/soft_tissue_tumor_benign/common" + Soft tissue tumor, malignant: + $ref: + - "_terms_enum.yaml#/soft_tissue_tumor_malignant/common" + Solid and cystic tumor: + $ref: + - "_terms_enum.yaml#/solid_and_cystic_tumor/common" + Solid and papillary epithelial neoplasm: + $ref: + - "_terms_enum.yaml#/solid_and_papillary_epithelial_neoplasm/common" + Solid carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/solid_carcinoma_nos/common" + Solid papillary carcinoma in situ: + $ref: + - "_terms_enum.yaml#/solid_papillary_carcinoma_in_situ/common" + Solid pseudopapillary tumor: + $ref: + - "_terms_enum.yaml#/solid_pseudopapillary_tumor/common" + Solid teratoma: + $ref: + - "_terms_enum.yaml#/solid_teratoma/common" + Solitary fibrous tumor: + $ref: + - "_terms_enum.yaml#/solitary_fibrous_tumor/common" + Solitary fibrous tumor, malignant: + $ref: + - "_terms_enum.yaml#/solitary_fibrous_tumor_malignant/common" + Solitary fibrous tumor/hemangiopericytoma Grade 1 (CNS): + $ref: + - "_terms_enum.yaml#/solitary_fibrous_tumorhemangiopericytoma_grade_1_cns/common" + Solitary fibrous tumor/hemangiopericytoma Grade 2 (CNS): + $ref: + - "_terms_enum.yaml#/solitary_fibrous_tumorhemangiopericytoma_grade_2_cns/common" + Solitary fibrous tumor/hemangiopericytoma Grade 3 (CNS): + $ref: + - "_terms_enum.yaml#/solitary_fibrous_tumorhemangiopericytoma_grade_3_cns/common" + Solitary mastocytoma of skin: + $ref: + - "_terms_enum.yaml#/solitary_mastocytoma_of_skin/common" + Solitary myeloma: + $ref: + - "_terms_enum.yaml#/solitary_myeloma/common" + Solitary plasmacytoma: + $ref: + - "_terms_enum.yaml#/solitary_plasmacytoma/common" + Somatostatin cell tumor, malignant: + $ref: + - "_terms_enum.yaml#/somatostatin_cell_tumor_malignant/common" + Somatostatin cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/somatostatin_cell_tumor_nos/common" + Somatostatinoma, malignant: + $ref: + - "_terms_enum.yaml#/somatostatinoma_malignant/common" + Somatostatinoma, NOS: + $ref: + - "_terms_enum.yaml#/somatostatinoma_nos/common" + Spermatocytic seminoma: + $ref: + - "_terms_enum.yaml#/spermatocytic_seminoma/common" + Spermatocytoma: + $ref: + - "_terms_enum.yaml#/spermatocytoma/common" + Spindle cell angioendothelioma: + $ref: + - "_terms_enum.yaml#/spindle_cell_angioendothelioma/common" + Spindle cell carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/spindle_cell_carcinoma_nos/common" + Spindle cell hemangioendothelioma: + $ref: + - "_terms_enum.yaml#/spindle_cell_hemangioendothelioma/common" + Spindle cell lipoma: + $ref: + - "_terms_enum.yaml#/spindle_cell_lipoma/common" + Spindle cell melanoma, NOS: + $ref: + - "_terms_enum.yaml#/spindle_cell_melanoma_nos/common" + Spindle cell melanoma, type A: + $ref: + - "_terms_enum.yaml#/spindle_cell_melanoma_type_a/common" + Spindle cell melanoma, type B: + $ref: + - "_terms_enum.yaml#/spindle_cell_melanoma_type_b/common" + Spindle cell nevus, NOS: + $ref: + - "_terms_enum.yaml#/spindle_cell_nevus_nos/common" + Spindle cell oncocytoma: + $ref: + - "_terms_enum.yaml#/spindle_cell_oncocytoma/common" + Spindle cell rhabdomyosarcoma: + $ref: + - "_terms_enum.yaml#/spindle_cell_rhabdomyosarcoma/common" + Spindle cell sarcoma: + $ref: + - "_terms_enum.yaml#/spindle_cell_sarcoma/common" + Spindle epithelial tumor with thymus-like differentiation: + $ref: + - "_terms_enum.yaml#/spindle_epithelial_tumor_with_thymuslike_differentiation/common" + Spindle epithelial tumor with thymus-like element: + $ref: + - "_terms_enum.yaml#/spindle_epithelial_tumor_with_thymuslike_element/common" + Spindled mesothelioma: + $ref: + - "_terms_enum.yaml#/spindled_mesothelioma/common" + Spiradenoma, NOS: + $ref: + - "_terms_enum.yaml#/spiradenoma_nos/common" + Spitz nevus: + $ref: + - "_terms_enum.yaml#/spitz_nevus/common" + Splenic B-cell lymphoma/leukemia, unclassifiable: + $ref: + - "_terms_enum.yaml#/splenic_bcell_lymphomaleukemia_unclassifiable/common" + Splenic diffuse red pulp small B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/splenic_diffuse_red_pulp_small_bcell_lymphoma/common" + Splenic marginal zone B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/splenic_marginal_zone_bcell_lymphoma/common" + Splenic marginal zone lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/splenic_marginal_zone_lymphoma_nos/common" + Spongioblastoma multiforme: + $ref: + - "_terms_enum.yaml#/spongioblastoma_multiforme/common" + Spongioblastoma polare: + $ref: + - "_terms_enum.yaml#/spongioblastoma_polare/common" + Spongioneuroblastoma: + $ref: + - "_terms_enum.yaml#/spongioneuroblastoma/common" + Squamotransitional cell carcinoma: + $ref: + - "_terms_enum.yaml#/squamotransitional_cell_carcinoma/common" + Squamous carcinoma: + $ref: + - "_terms_enum.yaml#/squamous_carcinoma/common" + Squamous cell carcinoma in situ with questionable stromal invasion: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_in_situ_with_questionable_stromal_invasion/common" + Squamous cell carcinoma in situ, NOS: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_in_situ_nos/common" + Squamous cell carcinoma with horn formation: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_with_horn_formation/common" + Squamous cell carcinoma, acantholytic: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_acantholytic/common" + Squamous cell carcinoma, adenoid: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_adenoid/common" + Squamous cell carcinoma, clear cell type: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_clear_cell_type/common" + Squamous cell carcinoma, HPV-positive: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_hpvpositive/common" + Squamous cell carcinoma, keratinizing, NOS: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_keratinizing_nos/common" + Squamous cell carcinoma, large cell, keratinizing: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_large_cell_keratinizing/common" + Squamous cell carcinoma, large cell, nonkeratinizing, NOS: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_large_cell_nonkeratinizing_nos/common" + Squamous cell carcinoma, metastatic, NOS: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_metastatic_nos/common" + Squamous cell carcinoma, microinvasive: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_microinvasive/common" + Squamous cell carcinoma, nonkeratinizing, NOS: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_nonkeratinizing_nos/common" + Squamous cell carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_nos/common" + Squamous cell carcinoma, pseudoglandular: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_pseudoglandular/common" + Squamous cell carcinoma, sarcomatoid: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_sarcomatoid/common" + Squamous cell carcinoma, small cell, nonkeratinizing: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_small_cell_nonkeratinizing/common" + Squamous cell carcinoma, spindle cell: + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_spindle_cell/common" + Squamous cell epithelioma: + $ref: + - "_terms_enum.yaml#/squamous_cell_epithelioma/common" + Squamous cell papilloma, inverted: + $ref: + - "_terms_enum.yaml#/squamous_cell_papilloma_inverted/common" + Squamous cell papilloma, NOS: + $ref: + - "_terms_enum.yaml#/squamous_cell_papilloma_nos/common" + Squamous intraepithelial neoplasia, grade I: + $ref: + - "_terms_enum.yaml#/squamous_intraepithelial_neoplasia_grade_i/common" + Squamous intraepithelial neoplasia, grade II: + $ref: + - "_terms_enum.yaml#/squamous_intraepithelial_neoplasia_grade_ii/common" + Squamous intraepithelial neoplasia, grade III: + $ref: + - "_terms_enum.yaml#/squamous_intraepithelial_neoplasia_grade_iii/common" + Squamous intraepithelial neoplasia, high grade: + $ref: + - "_terms_enum.yaml#/squamous_intraepithelial_neoplasia_high_grade/common" + Squamous intraepithelial neoplasia, low grade: + $ref: + - "_terms_enum.yaml#/squamous_intraepithelial_neoplasia_low_grade/common" + Squamous odontogenic tumor: + $ref: + - "_terms_enum.yaml#/squamous_odontogenic_tumor/common" + Squamous papilloma: + $ref: + - "_terms_enum.yaml#/squamous_papilloma/common" + Squamous papillomatosis: + $ref: + - "_terms_enum.yaml#/squamous_papillomatosis/common" + Stem cell leukemia: + $ref: + - "_terms_enum.yaml#/stem_cell_leukemia/common" + Steroid cell tumor, NOS: + $ref: + - "_terms_enum.yaml#/steroid_cell_tumor_nos/common" + Stromal endometriosis: + $ref: + - "_terms_enum.yaml#/stromal_endometriosis/common" + Stromal myosis, NOS: + $ref: + - "_terms_enum.yaml#/stromal_myosis_nos/common" + Stromal sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/stromal_sarcoma_nos/common" + Stromal tumor with minor sex cord elements: + $ref: + - "_terms_enum.yaml#/stromal_tumor_with_minor_sex_cord_elements/common" + Stromal tumor, benign: + $ref: + - "_terms_enum.yaml#/stromal_tumor_benign/common" + Stromal tumor, NOS: + $ref: + - "_terms_enum.yaml#/stromal_tumor_nos/common" + Struma ovarii and carcinoid: + $ref: + - "_terms_enum.yaml#/struma_ovarii_and_carcinoid/common" + Struma ovarii, malignant: + $ref: + - "_terms_enum.yaml#/struma_ovarii_malignant/common" + Struma ovarii, NOS: + $ref: + - "_terms_enum.yaml#/struma_ovarii_nos/common" + Strumal carcinoid: + $ref: + - "_terms_enum.yaml#/strumal_carcinoid/common" + Subacute granulocytic leukemia: + $ref: + - "_terms_enum.yaml#/subacute_granulocytic_leukemia/common" + Subacute myelogenous leukemia: + $ref: + - "_terms_enum.yaml#/subacute_myelogenous_leukemia/common" + Subacute myeloid leukemia: + $ref: + - "_terms_enum.yaml#/subacute_myeloid_leukemia/common" + Subareolar duct papillomatosis: + $ref: + - "_terms_enum.yaml#/subareolar_duct_papillomatosis/common" + Subcutaneous panniculitis-like T-cell lymphoma: + $ref: + - "_terms_enum.yaml#/subcutaneous_panniculitislike_tcell_lymphoma/common" + Subependymal giant cell astrocytoma: + $ref: + - "_terms_enum.yaml#/subependymal_giant_cell_astrocytoma/common" + Subependymal glioma: + $ref: + - "_terms_enum.yaml#/subependymal_glioma/common" + Subependymoma: + $ref: + - "_terms_enum.yaml#/subependymoma/common" + Subepidermal nodular fibrosis: + $ref: + - "_terms_enum.yaml#/subepidermal_nodular_fibrosis/common" + Superficial spreading adenocarcinoma: + $ref: + - "_terms_enum.yaml#/superficial_spreading_adenocarcinoma/common" + Superficial spreading melanoma: + $ref: + - "_terms_enum.yaml#/superficial_spreading_melanoma/common" + Superficial well differentiated liposarcoma: + $ref: + - "_terms_enum.yaml#/superficial_well_differentiated_liposarcoma/common" + Supratentorial PNET: + $ref: + - "_terms_enum.yaml#/supratentorial_pnet/common" + Sweat gland adenocarcinoma: + $ref: + - "_terms_enum.yaml#/sweat_gland_adenocarcinoma/common" + Sweat gland adenoma: + $ref: + - "_terms_enum.yaml#/sweat_gland_adenoma/common" + Sweat gland carcinoma: + $ref: + - "_terms_enum.yaml#/sweat_gland_carcinoma/common" + Sweat gland tumor, benign: + $ref: + - "_terms_enum.yaml#/sweat_gland_tumor_benign/common" + Sweat gland tumor, malignant: + $ref: + - "_terms_enum.yaml#/sweat_gland_tumor_malignant/common" + Sweat gland tumor, NOS: + $ref: + - "_terms_enum.yaml#/sweat_gland_tumor_nos/common" + Sympathetic paraganglioma: + $ref: + - "_terms_enum.yaml#/sympathetic_paraganglioma/common" + Symplastic leiomyoma: + $ref: + - "_terms_enum.yaml#/symplastic_leiomyoma/common" + Syncytial meningioma: + $ref: + - "_terms_enum.yaml#/syncytial_meningioma/common" + Synovial sarcoma, biphasic: + $ref: + - "_terms_enum.yaml#/synovial_sarcoma_biphasic/common" + Synovial sarcoma, epithelioid cell: + $ref: + - "_terms_enum.yaml#/synovial_sarcoma_epithelioid_cell/common" + Synovial sarcoma, monophasic fibrous: + $ref: + - "_terms_enum.yaml#/synovial_sarcoma_monophasic_fibrous/common" + Synovial sarcoma, NOS: + $ref: + - "_terms_enum.yaml#/synovial_sarcoma_nos/common" + Synovial sarcoma, spindle cell: + $ref: + - "_terms_enum.yaml#/synovial_sarcoma_spindle_cell/common" + Synovioma, benign: + $ref: + - "_terms_enum.yaml#/synovioma_benign/common" + Synovioma, malignant: + $ref: + - "_terms_enum.yaml#/synovioma_malignant/common" + Synovioma, NOS: + $ref: + - "_terms_enum.yaml#/synovioma_nos/common" + Syringocystadenoma papilliferum: + $ref: + - "_terms_enum.yaml#/syringocystadenoma_papilliferum/common" + Syringofibroadenoma: + $ref: + - "_terms_enum.yaml#/syringofibroadenoma/common" + Syringoma, NOS: + $ref: + - "_terms_enum.yaml#/syringoma_nos/common" + Syringomatous carcinoma: + $ref: + - "_terms_enum.yaml#/syringomatous_carcinoma/common" + Systemic EBV positive T-cell lymphoproliferative disease of childhood: + $ref: + - "_terms_enum.yaml#/systemic_ebv_positive_tcell_lymphoproliferative_disease_of_childhood/common" + Systemic light chain disease: + $ref: + - "_terms_enum.yaml#/systemic_light_chain_disease/common" + Systemic mastocytosis with AHNMD: + $ref: + - "_terms_enum.yaml#/systemic_mastocytosis_with_ahnmd/common" + Systemic mastocytosis with associated hematological clonal non-mast cell disorder: + $ref: + - "_terms_enum.yaml#/systemic_mastocytosis_with_associated_hematological_clonal_nonmast_cell_disorder/common" + Systemic tissue mast cell disease: + $ref: + - "_terms_enum.yaml#/systemic_tissue_mast_cell_disease/common" + T lymphoblastic leukemia/lymphoma: + $ref: + - "_terms_enum.yaml#/t_lymphoblastic_leukemialymphoma/common" + T-cell large granular lymphocytic leukemia: + $ref: + - "_terms_enum.yaml#/tcell_large_granular_lymphocytic_leukemia/common" + T-cell large granular lymphocytosis: + $ref: + - "_terms_enum.yaml#/tcell_large_granular_lymphocytosis/common" + T-cell lymphoma, NOS: + $ref: + - "_terms_enum.yaml#/tcell_lymphoma_nos/common" + T-cell rich large B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/tcell_rich_large_bcell_lymphoma/common" + T-cell rich/histiocyte-rich large B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/tcell_richhistiocyterich_large_bcell_lymphoma/common" + T-gamma lymphoproliferative disease: + $ref: + - "_terms_enum.yaml#/tgamma_lymphoproliferative_disease/common" + T-zone lymphoma: + $ref: + - "_terms_enum.yaml#/tzone_lymphoma/common" + T/NK-cell lymphoma: + $ref: + - "_terms_enum.yaml#/tnkcell_lymphoma/common" + Tanycytic ependymoma: + $ref: + - "_terms_enum.yaml#/tanycytic_ependymoma/common" + Telangiectatic osteosarcoma: + $ref: + - "_terms_enum.yaml#/telangiectatic_osteosarcoma/common" + Tenosynovial giant cell tumor: + $ref: + - "_terms_enum.yaml#/tenosynovial_giant_cell_tumor/common" + Teratoblastoma, malignant: + $ref: + - "_terms_enum.yaml#/teratoblastoma_malignant/common" + Teratocarcinoma: + $ref: + - "_terms_enum.yaml#/teratocarcinoma/common" + Teratoma with malignant transformation: + $ref: + - "_terms_enum.yaml#/teratoma_with_malignant_transformation/common" + Teratoma, benign: + $ref: + - "_terms_enum.yaml#/teratoma_benign/common" + Teratoma, differentiated: + $ref: + - "_terms_enum.yaml#/teratoma_differentiated/common" + Teratoma, malignant, NOS: + $ref: + - "_terms_enum.yaml#/teratoma_malignant_nos/common" + Teratoma, NOS: + $ref: + - "_terms_enum.yaml#/teratoma_nos/common" + Testicular adenoma: + $ref: + - "_terms_enum.yaml#/testicular_adenoma/common" + Theca cell tumor: + $ref: + - "_terms_enum.yaml#/theca_cell_tumor/common" + Theca cell-granulosa cell tumor: + $ref: + - "_terms_enum.yaml#/theca_cellgranulosa_cell_tumor/common" + Thecoma, luteinized: + $ref: + - "_terms_enum.yaml#/thecoma_luteinized/common" + Thecoma, malignant: + $ref: + - "_terms_enum.yaml#/thecoma_malignant/common" + Thecoma, NOS: + $ref: + - "_terms_enum.yaml#/thecoma_nos/common" + Therapy related myeloid neoplasm: + $ref: + - "_terms_enum.yaml#/therapy_related_myeloid_neoplasm/common" + Therapy-related acute myeloid leukemia, alkylating agent related: + $ref: + - "_terms_enum.yaml#/therapyrelated_acute_myeloid_leukemia_alkylating_agent_related/common" + Therapy-related acute myeloid leukemia, epipodophyllotoxin-related: + $ref: + - "_terms_enum.yaml#/therapyrelated_acute_myeloid_leukemia_epipodophyllotoxinrelated/common" + Therapy-related acute myeloid leukemia, NOS: + $ref: + - "_terms_enum.yaml#/therapyrelated_acute_myeloid_leukemia_nos/common" + Therapy-related myelodysplastic syndrome, alkylating agent related: + $ref: + - "_terms_enum.yaml#/therapyrelated_myelodysplastic_syndrome_alkylating_agent_related/common" + Therapy-related myelodysplastic syndrome, epipodophyllotoxin-related: + $ref: + - "_terms_enum.yaml#/therapyrelated_myelodysplastic_syndrome_epipodophyllotoxinrelated/common" + Therapy-related myelodysplastic syndrome, NOS: + $ref: + - "_terms_enum.yaml#/therapyrelated_myelodysplastic_syndrome_nos/common" + Thymic carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/thymic_carcinoma_nos/common" + Thymic large B-cell lymphoma: + $ref: + - "_terms_enum.yaml#/thymic_large_bcell_lymphoma/common" + Thymoma, atypical, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_atypical_malignant/common" + Thymoma, atypical, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_atypical_nos/common" + Thymoma, benign: + $ref: + - "_terms_enum.yaml#/thymoma_benign/common" + Thymoma, cortical, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_cortical_malignant/common" + Thymoma, cortical, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_cortical_nos/common" + Thymoma, epithelial, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_epithelial_malignant/common" + Thymoma, epithelial, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_epithelial_nos/common" + Thymoma, lymphocyte-rich, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_lymphocyterich_malignant/common" + Thymoma, lymphocyte-rich, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_lymphocyterich_nos/common" + Thymoma, lymphocytic, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_lymphocytic_malignant/common" + Thymoma, lymphocytic, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_lymphocytic_nos/common" + Thymoma, malignant, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_malignant_nos/common" + Thymoma, medullary, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_medullary_malignant/common" + Thymoma, medullary, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_medullary_nos/common" + Thymoma, mixed type, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_mixed_type_malignant/common" + Thymoma, mixed type, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_mixed_type_nos/common" + Thymoma, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_nos/common" + Thymoma, organoid, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_organoid_malignant/common" + Thymoma, organoid, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_organoid_nos/common" + Thymoma, predominantly cortical, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_predominantly_cortical_malignant/common" + Thymoma, predominantly cortical, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_predominantly_cortical_nos/common" + Thymoma, spindle cell, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_spindle_cell_malignant/common" + Thymoma, spindle cell, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_spindle_cell_nos/common" + Thymoma, type A, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_type_a_malignant/common" + Thymoma, type A, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_type_a_nos/common" + Thymoma, type AB, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_type_ab_malignant/common" + Thymoma, type AB, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_type_ab_nos/common" + Thymoma, type B1, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_type_b1_malignant/common" + Thymoma, type B1, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_type_b1_nos/common" + Thymoma, type B2, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_type_b2_malignant/common" + Thymoma, type B2, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_type_b2_nos/common" + Thymoma, type B3, malignant: + $ref: + - "_terms_enum.yaml#/thymoma_type_b3_malignant/common" + Thymoma, type B3, NOS: + $ref: + - "_terms_enum.yaml#/thymoma_type_b3_nos/common" + Thymoma, type C: + $ref: + - "_terms_enum.yaml#/thymoma_type_c/common" + Tibial adamantinoma: + $ref: + - "_terms_enum.yaml#/tibial_adamantinoma/common" + Trabecular adenocarcinoma: + $ref: + - "_terms_enum.yaml#/trabecular_adenocarcinoma/common" + Trabecular adenoma: + $ref: + - "_terms_enum.yaml#/trabecular_adenoma/common" + Trabecular carcinoma: + $ref: + - "_terms_enum.yaml#/trabecular_carcinoma/common" + Traditional serrated adenoma: + $ref: + - "_terms_enum.yaml#/traditional_serrated_adenoma/common" + Transient abnormal myelopoiesis: + $ref: + - "_terms_enum.yaml#/transient_abnormal_myelopoiesis/common" + Transitional carcinoma: + $ref: + - "_terms_enum.yaml#/transitional_carcinoma/common" + Transitional cell carcinoma: + $ref: + - "_terms_enum.yaml#/transitional_cell_carcinoma/common" + Transitional cell carcinoma in situ: + $ref: + - "_terms_enum.yaml#/transitional_cell_carcinoma_in_situ/common" + Transitional cell carcinoma, micropapillary: + $ref: + - "_terms_enum.yaml#/transitional_cell_carcinoma_micropapillary/common" + Transitional cell carcinoma, sarcomatoid: + $ref: + - "_terms_enum.yaml#/transitional_cell_carcinoma_sarcomatoid/common" + Transitional cell carcinoma, spindle cell: + $ref: + - "_terms_enum.yaml#/transitional_cell_carcinoma_spindle_cell/common" + Transitional cell papilloma, benign: + $ref: + - "_terms_enum.yaml#/transitional_cell_papilloma_benign/common" + Transitional cell papilloma, inverted, benign: + $ref: + - "_terms_enum.yaml#/transitional_cell_papilloma_inverted_benign/common" + Transitional cell papilloma, inverted, NOS: + $ref: + - "_terms_enum.yaml#/transitional_cell_papilloma_inverted_nos/common" + Transitional cell papilloma, NOS: + $ref: + - "_terms_enum.yaml#/transitional_cell_papilloma_nos/common" + Transitional meningioma: + $ref: + - "_terms_enum.yaml#/transitional_meningioma/common" + Transitional papilloma: + $ref: + - "_terms_enum.yaml#/transitional_papilloma/common" + Transitional papilloma, inverted, benign: + $ref: + - "_terms_enum.yaml#/transitional_papilloma_inverted_benign/common" + Transitional papilloma, inverted, NOS: + $ref: + - "_terms_enum.yaml#/transitional_papilloma_inverted_nos/common" + Trichilemmal carcinoma: + $ref: + - "_terms_enum.yaml#/trichilemmal_carcinoma/common" + Trichilemmocarcinoma: + $ref: + - "_terms_enum.yaml#/trichilemmocarcinoma/common" + Trichilemmoma: + $ref: + - "_terms_enum.yaml#/trichilemmoma/common" + Trichodiscoma: + $ref: + - "_terms_enum.yaml#/trichodiscoma/common" + Trichoepithelioma: + $ref: + - "_terms_enum.yaml#/trichoepithelioma/common" + Trichofolliculoma: + $ref: + - "_terms_enum.yaml#/trichofolliculoma/common" + Triton tumor, malignant: + $ref: + - "_terms_enum.yaml#/triton_tumor_malignant/common" + Trophoblastic tumor, epithelioid: + $ref: + - "_terms_enum.yaml#/trophoblastic_tumor_epithelioid/common" + True histiocytic lymphoma: + $ref: + - "_terms_enum.yaml#/true_histiocytic_lymphoma/common" + Tubular adenocarcinoma: + $ref: + - "_terms_enum.yaml#/tubular_adenocarcinoma/common" + Tubular adenoma, NOS: + $ref: + - "_terms_enum.yaml#/tubular_adenoma_nos/common" + Tubular androblastoma, NOS: + $ref: + - "_terms_enum.yaml#/tubular_androblastoma_nos/common" + Tubular carcinoma: + $ref: + - "_terms_enum.yaml#/tubular_carcinoma/common" + Tubulo-papillary adenoma: + $ref: + - "_terms_enum.yaml#/tubulopapillary_adenoma/common" + Tubulocystic renal cell carcinoma: + $ref: + - "_terms_enum.yaml#/tubulocystic_renal_cell_carcinoma/common" + Tubulolobular carcinoma: + $ref: + - "_terms_enum.yaml#/tubulolobular_carcinoma/common" + Tubulovillous adenoma, NOS: + $ref: + - "_terms_enum.yaml#/tubulovillous_adenoma_nos/common" + Tumor cells, malignant: + $ref: + - "_terms_enum.yaml#/tumor_cells_malignant/common" + Tumor cells, NOS: + $ref: + - "_terms_enum.yaml#/tumor_cells_nos/common" + Tumor cells, uncertain whether benign or malignant: + $ref: + - "_terms_enum.yaml#/tumor_cells_uncertain_whether_benign_or_malignant/common" + Tumor embolus: + $ref: + - "_terms_enum.yaml#/tumor_embolus/common" + Tumor, benign: + $ref: + - "_terms_enum.yaml#/tumor_benign/common" + Tumor, malignant, NOS: + $ref: + - "_terms_enum.yaml#/tumor_malignant_nos/common" + Tumor, metastatic: + $ref: + - "_terms_enum.yaml#/tumor_metastatic/common" + Tumor, NOS: + $ref: + - "_terms_enum.yaml#/tumor_nos/common" + Tumor, secondary: + $ref: + - "_terms_enum.yaml#/tumor_secondary/common" + Tumorlet, benign: + $ref: + - "_terms_enum.yaml#/tumorlet_benign/common" + Turban tumor: + $ref: + - "_terms_enum.yaml#/turban_tumor/common" + Unclassified tumor, benign: + $ref: + - "_terms_enum.yaml#/unclassified_tumor_benign/common" + Unclassified tumor, borderline malignancy: + $ref: + - "_terms_enum.yaml#/unclassified_tumor_borderline_malignancy/common" + Unclassified tumor, malignant: + $ref: + - "_terms_enum.yaml#/unclassified_tumor_malignant/common" + Unclassified tumor, malignant, uncertain whether primary or metastatic: + $ref: + - "_terms_enum.yaml#/unclassified_tumor_malignant_uncertain_whether_primary_or_metastatic/common" + Unclassified tumor, uncertain whether benign or malignant: + $ref: + - "_terms_enum.yaml#/unclassified_tumor_uncertain_whether_benign_or_malignant/common" + Undifferentiated epithelioid sarcoma: + $ref: + - "_terms_enum.yaml#/undifferentiated_epithelioid_sarcoma/common" + Undifferentiated high-grade pleomorphic sarcoma: + $ref: + - "_terms_enum.yaml#/undifferentiated_highgrade_pleomorphic_sarcoma/common" + Undifferentiated leukaemia: + $ref: + - "_terms_enum.yaml#/undifferentiated_leukaemia/common" + Undifferentiated pleomorphic sarcoma: + $ref: + - "_terms_enum.yaml#/undifferentiated_pleomorphic_sarcoma/common" + Undifferentiated round cell sarcoma: + $ref: + - "_terms_enum.yaml#/undifferentiated_round_cell_sarcoma/common" + Undifferentiated sarcoma: + $ref: + - "_terms_enum.yaml#/undifferentiated_sarcoma/common" + Undifferentiated spindle cell sarcoma: + $ref: + - "_terms_enum.yaml#/undifferentiated_spindle_cell_sarcoma/common" + Undifferentiated uterine sarcoma: + $ref: + - "_terms_enum.yaml#/undifferentiated_uterine_sarcoma/common" + Urachal carcinoma: + $ref: + - "_terms_enum.yaml#/urachal_carcinoma/common" + Urothelial carcinoma in situ: + $ref: + - "_terms_enum.yaml#/urothelial_carcinoma_in_situ/common" + Urothelial carcinoma with squamous differentiation: + $ref: + - "_terms_enum.yaml#/urothelial_carcinoma_with_squamous_differentiation/common" + Urothelial carcinoma with trophoblastic differentiation: + $ref: + - "_terms_enum.yaml#/urothelial_carcinoma_with_trophoblastic_differentiation/common" + Urothelial carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/urothelial_carcinoma_nos/common" + Urothelial papilloma, NOS: + $ref: + - "_terms_enum.yaml#/urothelial_papilloma_nos/common" + Urticaria pigmentosa: + $ref: + - "_terms_enum.yaml#/urticaria_pigmentosa/common" + Vaginal intraepithelial neoplasia, grade III: + $ref: + - "_terms_enum.yaml#/vaginal_intraepithelial_neoplasia_grade_iii/common" + VAIN III: + $ref: + - "_terms_enum.yaml#/vain_iii/common" + Vascular leiomyoma: + $ref: + - "_terms_enum.yaml#/vascular_leiomyoma/common" + Venous hemangioma: + $ref: + - "_terms_enum.yaml#/venous_hemangioma/common" + Verrucous carcinoma, NOS: + $ref: + - "_terms_enum.yaml#/verrucous_carcinoma_nos/common" + Verrucous epidermoid carcinoma: + $ref: + - "_terms_enum.yaml#/verrucous_epidermoid_carcinoma/common" + Verrucous keratotic hemangioma: + $ref: + - "_terms_enum.yaml#/verrucous_keratotic_hemangioma/common" + Verrucous papilloma: + $ref: + - "_terms_enum.yaml#/verrucous_papilloma/common" + Verrucous squamous cell carcinoma: + $ref: + - "_terms_enum.yaml#/verrucous_squamous_cell_carcinoma/common" + Villoglandular adenoma: + $ref: + - "_terms_enum.yaml#/villoglandular_adenoma/common" + Villoglandular carcinoma: + $ref: + - "_terms_enum.yaml#/villoglandular_carcinoma/common" + Villous adenocarcinoma: + $ref: + - "_terms_enum.yaml#/villous_adenocarcinoma/common" + Villous adenoma, NOS: + $ref: + - "_terms_enum.yaml#/villous_adenoma_nos/common" + VIN III: + $ref: + - "_terms_enum.yaml#/vin_iii/common" + Vipoma, malignant: + $ref: + - "_terms_enum.yaml#/vipoma_malignant/common" + Vipoma, NOS: + $ref: + - "_terms_enum.yaml#/vipoma_nos/common" + Von Recklinghausen disease: + $ref: + - "_terms_enum.yaml#/von_recklinghausen_disease/common" + Vulvar intraepithelial neoplasia, grade III: + $ref: + - "_terms_enum.yaml#/vulvar_intraepithelial_neoplasia_grade_iii/common" + Waldenstrom macroglobulinemia: + $ref: + - "_terms_enum.yaml#/waldenstrom_macroglobulinemia/common" + Warthin tumor: + $ref: + - "_terms_enum.yaml#/warthin_tumor/common" + Warty carcinoma: + $ref: + - "_terms_enum.yaml#/warty_carcinoma/common" + Water-clear cell adenocarcinoma: + $ref: + - "_terms_enum.yaml#/waterclear_cell_adenocarcinoma/common" + Water-clear cell adenoma: + $ref: + - "_terms_enum.yaml#/waterclear_cell_adenoma/common" + Water-clear cell carcinoma: + $ref: + - "_terms_enum.yaml#/waterclear_cell_carcinoma/common" + Well differentiated liposarcoma of superficial soft tissue: + $ref: + - "_terms_enum.yaml#/well_differentiated_liposarcoma_of_superficial_soft_tissue/common" + Well differentiated thymic carcinoma: + $ref: + - "_terms_enum.yaml#/well_differentiated_thymic_carcinoma/common" + Wilms tumor: + $ref: + - "_terms_enum.yaml#/wilms_tumor/common" + Wolffian duct adenoma: + $ref: + - "_terms_enum.yaml#/wolffian_duct_adenoma/common" + Wolffian duct carcinoma: + $ref: + - "_terms_enum.yaml#/wolffian_duct_carcinoma/common" + Wolffian duct tumor: + $ref: + - "_terms_enum.yaml#/wolffian_duct_tumor/common" + Xanthofibroma: + $ref: + - "_terms_enum.yaml#/xanthofibroma/common" + Yolk sac tumor: + $ref: + - "_terms_enum.yaml#/yolk_sac_tumor/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + primary_disease: + $ref: + - "_terms.yaml#/primary_disease/common" + type: boolean + + primary_gleason_grade: + $ref: + - "_terms.yaml#/primary_gleason_grade/common" + enum: + - Pattern 1 + - Pattern 2 + - Pattern 3 + - Pattern 4 + - Pattern 5 + - Unknown + - Not Reported + enumDef: + Pattern 1: + $ref: + - "_terms_enum.yaml#/pattern_1/common" + Pattern 2: + $ref: + - "_terms_enum.yaml#/pattern_2/common" + Pattern 3: + $ref: + - "_terms_enum.yaml#/pattern_3/common" + Pattern 4: + $ref: + - "_terms_enum.yaml#/pattern_4/common" + Pattern 5: + $ref: + - "_terms_enum.yaml#/pattern_5/common" + + prior_malignancy: + $ref: + - "_terms.yaml#/prior_malignancy/common" + enum: + - "yes" + - "no" + - unknown + - not reported + - Not Allowed To Collect + enumDef: + "yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "no": + $ref: + - "_terms_enum.yaml#/no/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + prior_treatment: + $ref: + - "_terms.yaml#/prior_treatment/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + - Not Allowed To Collect + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + progression_or_recurrence: + $ref: + - "_terms.yaml#/progression_or_recurrence/common" + enum: + - "yes" + - "no" + - unknown + - not reported + - Not Allowed To Collect + enumDef: + "yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "no": + $ref: + - "_terms_enum.yaml#/no/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + residual_disease: + $ref: + - "_terms.yaml#/residual_disease/common" + enum: + - R0 + - R1 + - R2 + - RX + - Unknown + - Not Reported + enumDef: + R0: + $ref: + - "_terms_enum.yaml#/r0/common" + R1: + $ref: + - "_terms_enum.yaml#/r1/common" + R2: + $ref: + - "_terms_enum.yaml#/r2/common" + RX: + $ref: + - "_terms_enum.yaml#/rx/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + satellite_nodule_present: + $ref: + - "_terms.yaml#/satellite_nodule_present/common" + enum: + - Absent + - Indeterminate + - Present + - Unknown + - Not Reported + enumDef: + Absent: + $ref: + - "_terms_enum.yaml#/absent/common" + Indeterminate: + $ref: + - "_terms_enum.yaml#/indeterminate/common" + Present: + $ref: + - "_terms_enum.yaml#/present/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + secondary_gleason_grade: + $ref: + - "_terms.yaml#/secondary_gleason_grade/common" + enum: + - Pattern 1 + - Pattern 2 + - Pattern 3 + - Pattern 4 + - Pattern 5 + - Unknown + - Not Reported + enumDef: + Pattern 1: + $ref: + - "_terms_enum.yaml#/pattern_1/common" + Pattern 2: + $ref: + - "_terms_enum.yaml#/pattern_2/common" + Pattern 3: + $ref: + - "_terms_enum.yaml#/pattern_3/common" + Pattern 4: + $ref: + - "_terms_enum.yaml#/pattern_4/common" + Pattern 5: + $ref: + - "_terms_enum.yaml#/pattern_5/common" + + site_of_resection_or_biopsy: + $ref: + - "_terms.yaml#/site_of_resection_or_biopsy/common" + enum: + - Abdomen, NOS + - Abdominal esophagus + - Accessory sinus, NOS + - Acoustic nerve + - Adrenal gland, NOS + - Ampulla of Vater + - Anal canal + - Anterior 2/3 of tongue, NOS + - Anterior floor of mouth + - Anterior mediastinum + - Anterior surface of epiglottis + - Anterior wall of bladder + - Anterior wall of nasopharynx + - Anus, NOS + - Aortic body and other paraganglia + - Appendix + - Ascending colon + - Autonomic nervous system, NOS + - Axillary tail of breast + - Base of tongue, NOS + - Biliary tract, NOS + - Bladder neck + - Bladder, NOS + - Blood + - Body of pancreas + - Body of penis + - Body of stomach + - Bone marrow + - Bone of limb, NOS + - Bone, NOS + - Bones of skull and face and associated joints + - Border of tongue + - Brain stem + - Brain, NOS + - Branchial cleft + - Breast, NOS + - Broad ligament + - Cardia, NOS + - Carotid body + - Cauda equina + - Cecum + - Central portion of breast + - Cerebellum, NOS + - Cerebral meninges + - Cerebrum + - Cervical esophagus + - Cervix uteri + - Cheek mucosa + - Choroid + - Ciliary body + - Clitoris + - Cloacogenic zone + - Colon, NOS + - Commissure of lip + - Conjunctiva + - Connective, subcutaneous and other soft tissues of abdomen + - Connective, subcutaneous and other soft tissues of head, face, and neck + - Connective, subcutaneous and other soft tissues of lower limb and hip + - Connective, subcutaneous and other soft tissues of pelvis + - Connective, subcutaneous and other soft tissues of thorax + - Connective, subcutaneous and other soft tissues of trunk, NOS + - Connective, subcutaneous and other soft tissues of upper limb and shoulder + - Connective, subcutaneous and other soft tissues, NOS + - Cornea, NOS + - Corpus uteri + - Cortex of adrenal gland + - Cranial nerve, NOS + - Craniopharyngeal duct + - Descended testis + - Descending colon + - Dome of bladder + - Dorsal surface of tongue, NOS + - Duodenum + - Endocervix + - Endocrine gland, NOS + - Endometrium + - Epididymis + - Esophagus, NOS + - Ethmoid sinus + - Exocervix + - External ear + - External lip, NOS + - External lower lip + - External upper lip + - Extrahepatic bile duct + - Eye, NOS + - Eyelid + - Fallopian tube + - Female genital tract, NOS + - Floor of mouth, NOS + - Frontal lobe + - Frontal sinus + - Fundus of stomach + - Fundus uteri + - Gallbladder + - Gastric antrum + - Gastrointestinal tract, NOS + - Glans penis + - Glottis + - Greater curvature of stomach, NOS + - Gum, NOS + - Hard palate + - Head of pancreas + - Head, face or neck, NOS + - Heart + - Hematopoietic system, NOS + - Hepatic flexure of colon + - Hypopharyngeal aspect of aryepiglottic fold + - Hypopharynx, NOS + - Ileum + - Ill-defined sites within respiratory system + - Intestinal tract, NOS + - Intra-abdominal lymph nodes + - Intrahepatic bile duct + - Intrathoracic lymph nodes + - Islets of Langerhans + - Isthmus uteri + - Jejunum + - Kidney, NOS + - Labium majus + - Labium minus + - Lacrimal gland + - Laryngeal cartilage + - Larynx, NOS + - Lateral floor of mouth + - Lateral wall of bladder + - Lateral wall of nasopharynx + - Lateral wall of oropharynx + - Lesser curvature of stomach, NOS + - Lingual tonsil + - Lip, NOS + - Liver + - Long bones of lower limb and associated joints + - Long bones of upper limb, scapula and associated joints + - Lower gum + - Lower limb, NOS + - Lower lobe, lung + - Lower third of esophagus + - Lower-inner quadrant of breast + - Lower-outer quadrant of breast + - Lung, NOS + - Lymph node, NOS + - Lymph nodes of axilla or arm + - Lymph nodes of head, face and neck + - Lymph nodes of inguinal region or leg + - Lymph nodes of multiple regions + - Main bronchus + - Major salivary gland, NOS + - Male genital organs, NOS + - Mandible + - Maxillary sinus + - Meckel diverticulum + - Mediastinum, NOS + - Medulla of adrenal gland + - Meninges, NOS + - Middle ear + - Middle lobe, lung + - Middle third of esophagus + - Mouth, NOS + - Mucosa of lip, NOS + - Mucosa of lower lip + - Mucosa of upper lip + - Myometrium + - Nasal cavity + - Nasopharynx, NOS + - Nervous system, NOS + - Nipple + - Occipital lobe + - Olfactory nerve + - Optic nerve + - Orbit, NOS + - Oropharynx, NOS + - Other ill-defined sites + - Other specified parts of female genital organs + - Other specified parts of male genital organs + - Other specified parts of pancreas + - Ovary + - Overlapping lesion of accessory sinuses + - Overlapping lesion of biliary tract + - Overlapping lesion of bladder + - Overlapping lesion of bones, joints and articular cartilage + - Overlapping lesion of bones, joints and articular cartilage of limbs + - Overlapping lesion of brain + - Overlapping lesion of brain and central nervous system + - Overlapping lesion of breast + - Overlapping lesion of cervix uteri + - Overlapping lesion of colon + - Overlapping lesion of connective, subcutaneous and other soft tissues + - Overlapping lesion of corpus uteri + - Overlapping lesion of digestive system + - Overlapping lesion of endocrine glands and related structures + - Overlapping lesion of esophagus + - Overlapping lesion of eye and adnexa + - Overlapping lesion of female genital organs + - Overlapping lesion of floor of mouth + - Overlapping lesion of heart, mediastinum and pleura + - Overlapping lesion of hypopharynx + - Overlapping lesion of ill-defined sites + - Overlapping lesion of larynx + - Overlapping lesion of lip + - Overlapping lesion of lip, oral cavity and pharynx + - Overlapping lesion of lung + - Overlapping lesion of major salivary glands + - Overlapping lesion of male genital organs + - Overlapping lesion of nasopharynx + - Overlapping lesion of other and unspecified parts of mouth + - Overlapping lesion of palate + - Overlapping lesion of pancreas + - Overlapping lesion of penis + - Overlapping lesion of peripheral nerves and autonomic nervous system + - Overlapping lesion of rectum, anus and anal canal + - Overlapping lesion of respiratory system and intrathoracic organs + - Overlapping lesion of retroperitoneum and peritoneum + - Overlapping lesion of skin + - Overlapping lesion of small intestine + - Overlapping lesion of stomach + - Overlapping lesion of tongue + - Overlapping lesion of tonsil + - Overlapping lesion of urinary organs + - Overlapping lesion of vulva + - Overlapping lesions of oropharynx + - Palate, NOS + - Pancreas, NOS + - Pancreatic duct + - Pancreatic neck + - Parametrium + - Parathyroid gland + - Paraurethral gland + - Parietal lobe + - Parotid gland + - Pelvic bones, sacrum, coccyx and associated joints + - Pelvic lymph nodes + - Pelvis, NOS + - Penis, NOS + - Peripheral nerves and autonomic nervous system of abdomen + - Peripheral nerves and autonomic nervous system of head, face, and neck + - Peripheral nerves and autonomic nervous system of lower limb and hip + - Peripheral nerves and autonomic nervous system of pelvis + - Peripheral nerves and autonomic nervous system of thorax + - Peripheral nerves and autonomic nervous system of trunk, NOS + - Peripheral nerves and autonomic nervous system of upper limb and shoulder + - Peritoneum, NOS + - Pharynx, NOS + - Pineal gland + - Pituitary gland + - Placenta + - Pleura, NOS + - Postcricoid region + - Posterior mediastinum + - Posterior wall of bladder + - Posterior wall of hypopharynx + - Posterior wall of nasopharynx + - Posterior wall of oropharynx + - Prepuce + - Prostate gland + - Pylorus + - Pyriform sinus + - Rectosigmoid junction + - Rectum, NOS + - Renal pelvis + - Reticuloendothelial system, NOS + - Retina + - Retromolar area + - Retroperitoneum + - Rib, sternum, clavicle and associated joints + - Round ligament + - Scrotum, NOS + - Short bones of lower limb and associated joints + - Short bones of upper limb and associated joints + - Sigmoid colon + - Skin of lip, NOS + - Skin of lower limb and hip + - Skin of other and unspecified parts of face + - Skin of scalp and neck + - Skin of trunk + - Skin of upper limb and shoulder + - Skin, NOS + - Small intestine, NOS + - Soft palate, NOS + - Specified parts of peritoneum + - Spermatic cord + - Sphenoid sinus + - Spinal cord + - Spinal meninges + - Spleen + - Splenic flexure of colon + - Stomach, NOS + - Subglottis + - Sublingual gland + - Submandibular gland + - Superior wall of nasopharynx + - Supraglottis + - Tail of pancreas + - Temporal lobe + - Testis, NOS + - Thoracic esophagus + - Thorax, NOS + - Thymus + - Thyroid gland + - Tongue, NOS + - Tonsil, NOS + - Tonsillar fossa + - Tonsillar pillar + - Trachea + - Transverse colon + - Trigone of bladder + - Undescended testis + - Unknown primary site + - Upper gum + - Upper limb, NOS + - Upper lobe, lung + - Upper respiratory tract, NOS + - Upper third of esophagus + - Upper-inner quadrant of breast + - Upper-outer quadrant of breast + - Urachus + - Ureter + - Ureteric orifice + - Urethra + - Urinary system, NOS + - Uterine adnexa + - Uterus, NOS + - Uvula + - Vagina, NOS + - Vallecula + - Ventral surface of tongue, NOS + - Ventricle, NOS + - Vertebral column + - Vestibule of mouth + - Vulva, NOS + - Waldeyer ring + - Unknown + - Not Reported + enumDef: + Abdomen, NOS: + $ref: + - "_terms_enum.yaml#/abdomen_nos/common" + Abdominal esophagus: + $ref: + - "_terms_enum.yaml#/abdominal_esophagus/common" + Accessory sinus, NOS: + $ref: + - "_terms_enum.yaml#/accessory_sinus_nos/common" + Acoustic nerve: + $ref: + - "_terms_enum.yaml#/acoustic_nerve/common" + Adrenal gland, NOS: + $ref: + - "_terms_enum.yaml#/adrenal_gland_nos/common" + Ampulla of Vater: + $ref: + - "_terms_enum.yaml#/ampulla_of_vater/common" + Anal canal: + $ref: + - "_terms_enum.yaml#/anal_canal/common" + Anterior mediastinum: + $ref: + - "_terms_enum.yaml#/anterior_mediastinum/common" + Anterior surface of epiglottis: + $ref: + - "_terms_enum.yaml#/anterior_surface_of_epiglottis/common" + Anterior wall of bladder: + $ref: + - "_terms_enum.yaml#/anterior_wall_of_bladder/common" + Anterior wall of nasopharynx: + $ref: + - "_terms_enum.yaml#/anterior_wall_of_nasopharynx/common" + Anus, NOS: + $ref: + - "_terms_enum.yaml#/anus_nos/common" + Appendix: + $ref: + - "_terms_enum.yaml#/appendix/common" + Ascending colon: + $ref: + - "_terms_enum.yaml#/ascending_colon/common" + Autonomic nervous system, NOS: + $ref: + - "_terms_enum.yaml#/autonomic_nervous_system_nos/common" + Axillary tail of breast: + $ref: + - "_terms_enum.yaml#/axillary_tail_of_breast/common" + Base of tongue, NOS: + $ref: + - "_terms_enum.yaml#/base_of_tongue_nos/common" + Biliary tract, NOS: + $ref: + - "_terms_enum.yaml#/biliary_tract_nos/common" + Bladder neck: + $ref: + - "_terms_enum.yaml#/bladder_neck/common" + Bladder, NOS: + $ref: + - "_terms_enum.yaml#/bladder_nos/common" + Blood: + $ref: + - "_terms_enum.yaml#/blood/common" + Body of pancreas: + $ref: + - "_terms_enum.yaml#/body_of_pancreas/common" + Body of penis: + $ref: + - "_terms_enum.yaml#/body_of_penis/common" + Body of stomach: + $ref: + - "_terms_enum.yaml#/body_of_stomach/common" + Bone marrow: + $ref: + - "_terms_enum.yaml#/bone_marrow/common" + Bone of limb, NOS: + $ref: + - "_terms_enum.yaml#/bone_of_limb_nos/common" + Bone, NOS: + $ref: + - "_terms_enum.yaml#/bone_nos/common" + Brain stem: + $ref: + - "_terms_enum.yaml#/brain_stem/common" + Brain, NOS: + $ref: + - "_terms_enum.yaml#/brain_nos/common" + Branchial cleft: + $ref: + - "_terms_enum.yaml#/branchial_cleft/common" + Breast, NOS: + $ref: + - "_terms_enum.yaml#/breast_nos/common" + Broad ligament: + $ref: + - "_terms_enum.yaml#/broad_ligament/common" + Cardia, NOS: + $ref: + - "_terms_enum.yaml#/cardia_nos/common" + Carotid body: + $ref: + - "_terms_enum.yaml#/carotid_body/common" + Cauda equina: + $ref: + - "_terms_enum.yaml#/cauda_equina/common" + Cecum: + $ref: + - "_terms_enum.yaml#/cecum/common" + Central portion of breast: + $ref: + - "_terms_enum.yaml#/central_portion_of_breast/common" + Cerebellum, NOS: + $ref: + - "_terms_enum.yaml#/cerebellum_nos/common" + Cerebral meninges: + $ref: + - "_terms_enum.yaml#/cerebral_meninges/common" + Cerebrum: + $ref: + - "_terms_enum.yaml#/cerebrum/common" + Cervical esophagus: + $ref: + - "_terms_enum.yaml#/cervical_esophagus/common" + Cervix uteri: + $ref: + - "_terms_enum.yaml#/cervix_uteri/common" + Cheek mucosa: + $ref: + - "_terms_enum.yaml#/cheek_mucosa/common" + Choroid: + $ref: + - "_terms_enum.yaml#/choroid/common" + Ciliary body: + $ref: + - "_terms_enum.yaml#/ciliary_body/common" + Clitoris: + $ref: + - "_terms_enum.yaml#/clitoris/common" + Cloacogenic zone: + $ref: + - "_terms_enum.yaml#/cloacogenic_zone/common" + Colon, NOS: + $ref: + - "_terms_enum.yaml#/colon_nos/common" + Commissure of lip: + $ref: + - "_terms_enum.yaml#/commissure_of_lip/common" + Conjunctiva: + $ref: + - "_terms_enum.yaml#/conjunctiva/common" + Cornea, NOS: + $ref: + - "_terms_enum.yaml#/cornea_nos/common" + Corpus uteri: + $ref: + - "_terms_enum.yaml#/corpus_uteri/common" + Cortex of adrenal gland: + $ref: + - "_terms_enum.yaml#/cortex_of_adrenal_gland/common" + Cranial nerve, NOS: + $ref: + - "_terms_enum.yaml#/cranial_nerve_nos/common" + Craniopharyngeal duct: + $ref: + - "_terms_enum.yaml#/craniopharyngeal_duct/common" + Descending colon: + $ref: + - "_terms_enum.yaml#/descending_colon/common" + Dome of bladder: + $ref: + - "_terms_enum.yaml#/dome_of_bladder/common" + Duodenum: + $ref: + - "_terms_enum.yaml#/duodenum/common" + Endocervix: + $ref: + - "_terms_enum.yaml#/endocervix/common" + Endocrine gland, NOS: + $ref: + - "_terms_enum.yaml#/endocrine_gland_nos/common" + Endometrium: + $ref: + - "_terms_enum.yaml#/endometrium/common" + Epididymis: + $ref: + - "_terms_enum.yaml#/epididymis/common" + Esophagus, NOS: + $ref: + - "_terms_enum.yaml#/esophagus_nos/common" + Ethmoid sinus: + $ref: + - "_terms_enum.yaml#/ethmoid_sinus/common" + Exocervix: + $ref: + - "_terms_enum.yaml#/exocervix/common" + External ear: + $ref: + - "_terms_enum.yaml#/external_ear/common" + External lip, NOS: + $ref: + - "_terms_enum.yaml#/external_lip_nos/common" + External lower lip: + $ref: + - "_terms_enum.yaml#/external_lower_lip/common" + External upper lip: + $ref: + - "_terms_enum.yaml#/external_upper_lip/common" + Extrahepatic bile duct: + $ref: + - "_terms_enum.yaml#/extrahepatic_bile_duct/common" + Eye, NOS: + $ref: + - "_terms_enum.yaml#/eye_nos/common" + Eyelid: + $ref: + - "_terms_enum.yaml#/eyelid/common" + Fallopian tube: + $ref: + - "_terms_enum.yaml#/fallopian_tube/common" + Female genital tract, NOS: + $ref: + - "_terms_enum.yaml#/female_genital_tract_nos/common" + Floor of mouth, NOS: + $ref: + - "_terms_enum.yaml#/floor_of_mouth_nos/common" + Frontal lobe: + $ref: + - "_terms_enum.yaml#/frontal_lobe/common" + Frontal sinus: + $ref: + - "_terms_enum.yaml#/frontal_sinus/common" + Fundus of stomach: + $ref: + - "_terms_enum.yaml#/fundus_of_stomach/common" + Fundus uteri: + $ref: + - "_terms_enum.yaml#/fundus_uteri/common" + Gallbladder: + $ref: + - "_terms_enum.yaml#/gallbladder/common" + Gastric antrum: + $ref: + - "_terms_enum.yaml#/gastric_antrum/common" + Gastrointestinal tract, NOS: + $ref: + - "_terms_enum.yaml#/gastrointestinal_tract_nos/common" + Glans penis: + $ref: + - "_terms_enum.yaml#/glans_penis/common" + Glottis: + $ref: + - "_terms_enum.yaml#/glottis/common" + Greater curvature of stomach, NOS: + $ref: + - "_terms_enum.yaml#/greater_curvature_of_stomach_nos/common" + Gum, NOS: + $ref: + - "_terms_enum.yaml#/gum_nos/common" + Hard palate: + $ref: + - "_terms_enum.yaml#/hard_palate/common" + Head of pancreas: + $ref: + - "_terms_enum.yaml#/head_of_pancreas/common" + Heart: + $ref: + - "_terms_enum.yaml#/heart/common" + Hematopoietic system, NOS: + $ref: + - "_terms_enum.yaml#/hematopoietic_system_nos/common" + Hepatic flexure of colon: + $ref: + - "_terms_enum.yaml#/hepatic_flexure_of_colon/common" + Hypopharynx, NOS: + $ref: + - "_terms_enum.yaml#/hypopharynx_nos/common" + Ileum: + $ref: + - "_terms_enum.yaml#/ileum/common" + Ill-defined sites within respiratory system: + $ref: + - "_terms_enum.yaml#/illdefined_sites_within_respiratory_system/common" + Intestinal tract, NOS: + $ref: + - "_terms_enum.yaml#/intestinal_tract_nos/common" + Intra-abdominal lymph nodes: + $ref: + - "_terms_enum.yaml#/intraabdominal_lymph_nodes/common" + Intrahepatic bile duct: + $ref: + - "_terms_enum.yaml#/intrahepatic_bile_duct/common" + Intrathoracic lymph nodes: + $ref: + - "_terms_enum.yaml#/intrathoracic_lymph_nodes/common" + Islets of Langerhans: + $ref: + - "_terms_enum.yaml#/islets_of_langerhans/common" + Isthmus uteri: + $ref: + - "_terms_enum.yaml#/isthmus_uteri/common" + Jejunum: + $ref: + - "_terms_enum.yaml#/jejunum/common" + Kidney, NOS: + $ref: + - "_terms_enum.yaml#/kidney_nos/common" + Labium majus: + $ref: + - "_terms_enum.yaml#/labium_majus/common" + Labium minus: + $ref: + - "_terms_enum.yaml#/labium_minus/common" + Lacrimal gland: + $ref: + - "_terms_enum.yaml#/lacrimal_gland/common" + Laryngeal cartilage: + $ref: + - "_terms_enum.yaml#/laryngeal_cartilage/common" + Larynx, NOS: + $ref: + - "_terms_enum.yaml#/larynx_nos/common" + Lateral wall of bladder: + $ref: + - "_terms_enum.yaml#/lateral_wall_of_bladder/common" + Lateral wall of nasopharynx: + $ref: + - "_terms_enum.yaml#/lateral_wall_of_nasopharynx/common" + Lateral wall of oropharynx: + $ref: + - "_terms_enum.yaml#/lateral_wall_of_oropharynx/common" + Lesser curvature of stomach, NOS: + $ref: + - "_terms_enum.yaml#/lesser_curvature_of_stomach_nos/common" + Lingual tonsil: + $ref: + - "_terms_enum.yaml#/lingual_tonsil/common" + Lip, NOS: + $ref: + - "_terms_enum.yaml#/lip_nos/common" + Liver: + $ref: + - "_terms_enum.yaml#/liver/common" + Lower gum: + $ref: + - "_terms_enum.yaml#/lower_gum/common" + Lower limb, NOS: + $ref: + - "_terms_enum.yaml#/lower_limb_nos/common" + Lower lobe, lung: + $ref: + - "_terms_enum.yaml#/lower_lobe_lung/common" + Lower third of esophagus: + $ref: + - "_terms_enum.yaml#/lower_third_of_esophagus/common" + Lower-inner quadrant of breast: + $ref: + - "_terms_enum.yaml#/lowerinner_quadrant_of_breast/common" + Lower-outer quadrant of breast: + $ref: + - "_terms_enum.yaml#/lowerouter_quadrant_of_breast/common" + Lung, NOS: + $ref: + - "_terms_enum.yaml#/lung_nos/common" + Lymph node, NOS: + $ref: + - "_terms_enum.yaml#/lymph_node_nos/common" + Lymph nodes of axilla or arm: + $ref: + - "_terms_enum.yaml#/lymph_nodes_of_axilla_or_arm/common" + Lymph nodes of head, face and neck: + $ref: + - "_terms_enum.yaml#/lymph_nodes_of_head_face_and_neck/common" + Lymph nodes of inguinal region or leg: + $ref: + - "_terms_enum.yaml#/lymph_nodes_of_inguinal_region_or_leg/common" + Main bronchus: + $ref: + - "_terms_enum.yaml#/main_bronchus/common" + Major salivary gland, NOS: + $ref: + - "_terms_enum.yaml#/major_salivary_gland_nos/common" + Male genital organs, NOS: + $ref: + - "_terms_enum.yaml#/male_genital_organs_nos/common" + Mandible: + $ref: + - "_terms_enum.yaml#/mandible/common" + Maxillary sinus: + $ref: + - "_terms_enum.yaml#/maxillary_sinus/common" + Meckel diverticulum: + $ref: + - "_terms_enum.yaml#/meckel_diverticulum/common" + Mediastinum, NOS: + $ref: + - "_terms_enum.yaml#/mediastinum_nos/common" + Medulla of adrenal gland: + $ref: + - "_terms_enum.yaml#/medulla_of_adrenal_gland/common" + Meninges, NOS: + $ref: + - "_terms_enum.yaml#/meninges_nos/common" + Middle ear: + $ref: + - "_terms_enum.yaml#/middle_ear/common" + Middle lobe, lung: + $ref: + - "_terms_enum.yaml#/middle_lobe_lung/common" + Middle third of esophagus: + $ref: + - "_terms_enum.yaml#/middle_third_of_esophagus/common" + Mouth, NOS: + $ref: + - "_terms_enum.yaml#/mouth_nos/common" + Mucosa of lip, NOS: + $ref: + - "_terms_enum.yaml#/mucosa_of_lip_nos/common" + Mucosa of lower lip: + $ref: + - "_terms_enum.yaml#/mucosa_of_lower_lip/common" + Mucosa of upper lip: + $ref: + - "_terms_enum.yaml#/mucosa_of_upper_lip/common" + Myometrium: + $ref: + - "_terms_enum.yaml#/myometrium/common" + Nasal cavity: + $ref: + - "_terms_enum.yaml#/nasal_cavity/common" + Nasopharynx, NOS: + $ref: + - "_terms_enum.yaml#/nasopharynx_nos/common" + Nervous system, NOS: + $ref: + - "_terms_enum.yaml#/nervous_system_nos/common" + Nipple: + $ref: + - "_terms_enum.yaml#/nipple/common" + Occipital lobe: + $ref: + - "_terms_enum.yaml#/occipital_lobe/common" + Olfactory nerve: + $ref: + - "_terms_enum.yaml#/olfactory_nerve/common" + Optic nerve: + $ref: + - "_terms_enum.yaml#/optic_nerve/common" + Orbit, NOS: + $ref: + - "_terms_enum.yaml#/orbit_nos/common" + Oropharynx, NOS: + $ref: + - "_terms_enum.yaml#/oropharynx_nos/common" + Other ill-defined sites: + $ref: + - "_terms_enum.yaml#/other_illdefined_sites/common" + Other specified parts of female genital organs: + $ref: + - "_terms_enum.yaml#/other_specified_parts_of_female_genital_organs/common" + Other specified parts of male genital organs: + $ref: + - "_terms_enum.yaml#/other_specified_parts_of_male_genital_organs/common" + Other specified parts of pancreas: + $ref: + - "_terms_enum.yaml#/other_specified_parts_of_pancreas/common" + Ovary: + $ref: + - "_terms_enum.yaml#/ovary/common" + Palate, NOS: + $ref: + - "_terms_enum.yaml#/palate_nos/common" + Pancreas, NOS: + $ref: + - "_terms_enum.yaml#/pancreas_nos/common" + Pancreatic duct: + $ref: + - "_terms_enum.yaml#/pancreatic_duct/common" + Parametrium: + $ref: + - "_terms_enum.yaml#/parametrium/common" + Parathyroid gland: + $ref: + - "_terms_enum.yaml#/parathyroid_gland/common" + Paraurethral gland: + $ref: + - "_terms_enum.yaml#/paraurethral_gland/common" + Parietal lobe: + $ref: + - "_terms_enum.yaml#/parietal_lobe/common" + Parotid gland: + $ref: + - "_terms_enum.yaml#/parotid_gland/common" + Pelvic lymph nodes: + $ref: + - "_terms_enum.yaml#/pelvic_lymph_nodes/common" + Pelvis, NOS: + $ref: + - "_terms_enum.yaml#/pelvis_nos/common" + Penis, NOS: + $ref: + - "_terms_enum.yaml#/penis_nos/common" + Peritoneum, NOS: + $ref: + - "_terms_enum.yaml#/peritoneum_nos/common" + Pharynx, NOS: + $ref: + - "_terms_enum.yaml#/pharynx_nos/common" + Pineal gland: + $ref: + - "_terms_enum.yaml#/pineal_gland/common" + Pituitary gland: + $ref: + - "_terms_enum.yaml#/pituitary_gland/common" + Placenta: + $ref: + - "_terms_enum.yaml#/placenta/common" + Pleura, NOS: + $ref: + - "_terms_enum.yaml#/pleura_nos/common" + Postcricoid region: + $ref: + - "_terms_enum.yaml#/postcricoid_region/common" + Posterior mediastinum: + $ref: + - "_terms_enum.yaml#/posterior_mediastinum/common" + Posterior wall of bladder: + $ref: + - "_terms_enum.yaml#/posterior_wall_of_bladder/common" + Posterior wall of hypopharynx: + $ref: + - "_terms_enum.yaml#/posterior_wall_of_hypopharynx/common" + Posterior wall of nasopharynx: + $ref: + - "_terms_enum.yaml#/posterior_wall_of_nasopharynx/common" + Posterior wall of oropharynx: + $ref: + - "_terms_enum.yaml#/posterior_wall_of_oropharynx/common" + Prepuce: + $ref: + - "_terms_enum.yaml#/prepuce/common" + Prostate gland: + $ref: + - "_terms_enum.yaml#/prostate_gland/common" + Pylorus: + $ref: + - "_terms_enum.yaml#/pylorus/common" + Pyriform sinus: + $ref: + - "_terms_enum.yaml#/pyriform_sinus/common" + Rectosigmoid junction: + $ref: + - "_terms_enum.yaml#/rectosigmoid_junction/common" + Rectum, NOS: + $ref: + - "_terms_enum.yaml#/rectum_nos/common" + Renal pelvis: + $ref: + - "_terms_enum.yaml#/renal_pelvis/common" + Reticuloendothelial system, NOS: + $ref: + - "_terms_enum.yaml#/reticuloendothelial_system_nos/common" + Retina: + $ref: + - "_terms_enum.yaml#/retina/common" + Retromolar area: + $ref: + - "_terms_enum.yaml#/retromolar_area/common" + Retroperitoneum: + $ref: + - "_terms_enum.yaml#/retroperitoneum/common" + Round ligament: + $ref: + - "_terms_enum.yaml#/round_ligament/common" + Scrotum, NOS: + $ref: + - "_terms_enum.yaml#/scrotum_nos/common" + Sigmoid colon: + $ref: + - "_terms_enum.yaml#/sigmoid_colon/common" + Skin of lip, NOS: + $ref: + - "_terms_enum.yaml#/skin_of_lip_nos/common" + Skin of lower limb and hip: + $ref: + - "_terms_enum.yaml#/skin_of_lower_limb_and_hip/common" + Skin of other and unspecified parts of face: + $ref: + - "_terms_enum.yaml#/skin_of_other_and_unspecified_parts_of_face/common" + Skin of scalp and neck: + $ref: + - "_terms_enum.yaml#/skin_of_scalp_and_neck/common" + Skin of trunk: + $ref: + - "_terms_enum.yaml#/skin_of_trunk/common" + Skin of upper limb and shoulder: + $ref: + - "_terms_enum.yaml#/skin_of_upper_limb_and_shoulder/common" + Skin, NOS: + $ref: + - "_terms_enum.yaml#/skin_nos/common" + Small intestine, NOS: + $ref: + - "_terms_enum.yaml#/small_intestine_nos/common" + Soft palate, NOS: + $ref: + - "_terms_enum.yaml#/soft_palate_nos/common" + Spermatic cord: + $ref: + - "_terms_enum.yaml#/spermatic_cord/common" + Sphenoid sinus: + $ref: + - "_terms_enum.yaml#/sphenoid_sinus/common" + Spinal cord: + $ref: + - "_terms_enum.yaml#/spinal_cord/common" + Spinal meninges: + $ref: + - "_terms_enum.yaml#/spinal_meninges/common" + Spleen: + $ref: + - "_terms_enum.yaml#/spleen/common" + Splenic flexure of colon: + $ref: + - "_terms_enum.yaml#/splenic_flexure_of_colon/common" + Stomach, NOS: + $ref: + - "_terms_enum.yaml#/stomach_nos/common" + Subglottis: + $ref: + - "_terms_enum.yaml#/subglottis/common" + Sublingual gland: + $ref: + - "_terms_enum.yaml#/sublingual_gland/common" + Submandibular gland: + $ref: + - "_terms_enum.yaml#/submandibular_gland/common" + Superior wall of nasopharynx: + $ref: + - "_terms_enum.yaml#/superior_wall_of_nasopharynx/common" + Supraglottis: + $ref: + - "_terms_enum.yaml#/supraglottis/common" + Tail of pancreas: + $ref: + - "_terms_enum.yaml#/tail_of_pancreas/common" + Temporal lobe: + $ref: + - "_terms_enum.yaml#/temporal_lobe/common" + Testis, NOS: + $ref: + - "_terms_enum.yaml#/testis_nos/common" + Thoracic esophagus: + $ref: + - "_terms_enum.yaml#/thoracic_esophagus/common" + Thorax, NOS: + $ref: + - "_terms_enum.yaml#/thorax_nos/common" + Thymus: + $ref: + - "_terms_enum.yaml#/thymus/common" + Thyroid gland: + $ref: + - "_terms_enum.yaml#/thyroid_gland/common" + Tongue, NOS: + $ref: + - "_terms_enum.yaml#/tongue_nos/common" + Tonsil, NOS: + $ref: + - "_terms_enum.yaml#/tonsil_nos/common" + Tonsillar fossa: + $ref: + - "_terms_enum.yaml#/tonsillar_fossa/common" + Tonsillar pillar: + $ref: + - "_terms_enum.yaml#/tonsillar_pillar/common" + Trachea: + $ref: + - "_terms_enum.yaml#/trachea/common" + Transverse colon: + $ref: + - "_terms_enum.yaml#/transverse_colon/common" + Trigone of bladder: + $ref: + - "_terms_enum.yaml#/trigone_of_bladder/common" + Undescended testis: + $ref: + - "_terms_enum.yaml#/undescended_testis/common" + Unknown primary site: + $ref: + - "_terms_enum.yaml#/unknown_primary_site/common" + Upper gum: + $ref: + - "_terms_enum.yaml#/upper_gum/common" + Upper limb, NOS: + $ref: + - "_terms_enum.yaml#/upper_limb_nos/common" + Upper lobe, lung: + $ref: + - "_terms_enum.yaml#/upper_lobe_lung/common" + Upper respiratory tract, NOS: + $ref: + - "_terms_enum.yaml#/upper_respiratory_tract_nos/common" + Upper third of esophagus: + $ref: + - "_terms_enum.yaml#/upper_third_of_esophagus/common" + Upper-inner quadrant of breast: + $ref: + - "_terms_enum.yaml#/upperinner_quadrant_of_breast/common" + Upper-outer quadrant of breast: + $ref: + - "_terms_enum.yaml#/upperouter_quadrant_of_breast/common" + Urachus: + $ref: + - "_terms_enum.yaml#/urachus/common" + Ureter: + $ref: + - "_terms_enum.yaml#/ureter/common" + Ureteric orifice: + $ref: + - "_terms_enum.yaml#/ureteric_orifice/common" + Urethra: + $ref: + - "_terms_enum.yaml#/urethra/common" + Urinary system, NOS: + $ref: + - "_terms_enum.yaml#/urinary_system_nos/common" + Uterine adnexa: + $ref: + - "_terms_enum.yaml#/uterine_adnexa/common" + Uterus, NOS: + $ref: + - "_terms_enum.yaml#/uterus_nos/common" + Uvula: + $ref: + - "_terms_enum.yaml#/uvula/common" + Vagina, NOS: + $ref: + - "_terms_enum.yaml#/vagina_nos/common" + Vallecula: + $ref: + - "_terms_enum.yaml#/vallecula/common" + Ventricle, NOS: + $ref: + - "_terms_enum.yaml#/ventricle_nos/common" + Vertebral column: + $ref: + - "_terms_enum.yaml#/vertebral_column/common" + Vestibule of mouth: + $ref: + - "_terms_enum.yaml#/vestibule_of_mouth/common" + Vulva, NOS: + $ref: + - "_terms_enum.yaml#/vulva_nos/common" + Waldeyer ring: + $ref: + - "_terms_enum.yaml#/waldeyer_ring/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + sites_of_involvement: + $ref: + - "_terms.yaml#/sites_of_involvement/common" + type: array + items: + enum: + - Abdomen + - Abdominal Peritoneum + - Adnexa + - Adrenal gland, NOS + - Anus, NOS + - Appendix + - Ascites + - Bladder, NOS + - Bone marrow + - Bone, NOS + - Brain, Brain stem + - Brain, Cerebellum, NOS + - Brain, Cerebrum + - Brain, Frontal lobe + - Brain, NOS + - Brain, Occipital lobe + - Brain, Parietal + - Brain, Temporal lobe + - Brain, Ventricle, NOS + - Breast, Left Lower Inner + - Breast, Left Lower Outer + - Breast, Left Upper Inner + - Breast, Left Upper Outer + - Breast, NOS + - Breast, Right Lower Inner + - Breast, Right Lower Outer + - Breast, Right Upper Inner + - Breast, Right Upper Outer + - Bronchus + - Buccal mucosa + - Central Lung + - Central nervous system + - Cerebrospinal fluid + - Cervix + - Chest wall + - Colon, NOS + - Common or Superficial Femoral Vein + - Diaphragm + - Distant Nodes + - Distant Organ + - Dura Mater + - Ear + - Epididymis + - Esophagus + - Esophagus, Lower Third + - Esophagus, Middle Third + - Esophagus, NOS + - Esophagus, Upper Third + - Eye + - Eye, Choroid + - Eye, Ciliary Body + - Eye, Iris + - Fallopian Tube, Left + - Fallopian Tube, NOS + - Fallopian Tube, Right + - Gallbladder + - Gastrointestinal Tract + - Gastrosplenic Ligament + - Great Blood Vessel + - Groin + - Head, Face or Neck, NOS + - Heart + - Hilar Fat + - Inferior Vena Cava + - Kidney, Lower Pole + - Kidney, Middle + - Kidney, NOS + - Kidney, Upper Pole + - Larynx, NOS + - Leptomeninges + - Liver + - Lower lobe, lung + - Lung, NOS + - Lymph Node, Axillary + - Lymph Node, Cervical + - Lymph Node, Femoral + - Lymph Node, Hilar + - Lymph Node, Iliac-Common + - Lymph Node, Iliac-External + - Lymph Node, Inguinal + - Lymph Node, Mediastinal + - Lymph Node, Mesenteric + - Lymph node, NOS + - Lymph Node, Para-Aortic + - Lymph Node, Regional + - Lymph Node, Retroperitoneal + - Lymph Node, Splenic + - Lymph Node, Subcarinal + - Lymph Node, Submandibular + - Lymph Node, Supraclavicular + - Mandible + - Maxilla + - Mediastinal soft tissue + - Mediastinum + - Mesentery + - Mesothelium + - Middle lobe, lung + - Mouth + - Nasal soft tissue + - Nasopharynx + - Neck + - Ocular orbits + - Omentum + - Oropharynx + - Ovary, Left + - Ovary, NOS + - Ovary, Right + - Pancreas + - Pancreas Body + - Pancreas Duct + - Pancreas Head + - Pancreas Tail + - Pancreas, NOS + - Parametrium, Left + - Parametrium, NOS + - Parametrium, Right + - Parotid gland + - Pelvic Lymph Node(s) + - Pelvic Peritoneum + - Pelvic Vein, Common, External or Iliac + - Pelvis + - Peri-aortic Lymph Node(s) + - Peri-orbital soft tissue + - Pericardium + - Perineum + - Peripheral blood + - Peripheral Lung + - Peripheral nervous system + - Peritoneal Cavity + - Peritoneum, NOS + - Pleura + - Prostate + - Rectum + - Renal Vein + - Rete Testis + - Retroperitoneum + - Salivary gland + - Scalp + - Scrotum + - Sigmoid colon + - Sinus + - Skin + - Skin, Extremities + - Skin, Groin + - Skin, Head and Neck + - Skin, Trunk + - Small intestine + - Soft tissue + - Spermatic Cord + - Spinal Cord + - Spleen + - Stomach + - Testes + - Thorax, NOS + - Thyroid + - Thyroid Gland Isthmus + - Tongue + - Tonsil + - Trachea + - Transplanted kidney + - Transverse colon + - Tunica Albuginea + - Tunica Vaginalis + - Upper lobe, lung + - Urethra + - Uterus + - Vagina + - Vertebrae + - Vertebral Canal + - Vulva, NOS + - Other + - Unknown + - Not Reported + deprecated_enum: + - Esophagus + - Pancreas + enumDef: + Ascites: + $ref: + - "_terms_enum.yaml#/ascites/common" + Common or Superficial Femoral Vein: + $ref: + - "_terms_enum.yaml#/common_superficial_femoral_vein/common" + Gastrointestinal Tract: + $ref: + - "_terms_enum.yaml#/gastrointestinal_tract_nos/common" + Great Blood Vessel: + $ref: + - "_terms_enum.yaml#/great_blood_vessel/common" + Groin: + $ref: + - "_terms_enum.yaml#/groin/common" + Inferior Vena Cava: + $ref: + - "_terms_enum.yaml#/inferior_vena_cava/common" + Kidney, Lower Pole: + $ref: + - "_terms_enum.yaml#/kidney_lower_pole/common" + Kidney, Upper Pole: + $ref: + - "_terms_enum.yaml#/kidney_upper_pole/common" + Lymph Node, Axillary: + $ref: + - "_terms_enum.yaml#/lymph_node_axillary/common" + Lymph Node, Inguinal: + $ref: + - "_terms_enum.yaml#/lymph_node_inguinal/common" + Mediastinum: + $ref: + - "_terms_enum.yaml#/mediastinum/common" + Omentum: + $ref: + - "_terms_enum.yaml#/omentum/common" + Pelvic Vein, Common, External or Iliac: + $ref: + - "_terms_enum.yaml#/iliac_vein/common" + Peritoneal Cavity: + $ref: + - "_terms_enum.yaml#/peritoneal_cavity/common" + Renal Vein: + $ref: + - "_terms_enum.yaml#/renal_vein/common" + Scalp: + $ref: + - "_terms_enum.yaml#/scalp/common" + Spinal Cord: + $ref: + - "_terms_enum.yaml#/spinal_cord/common" + Thyroid Gland Isthmus: + $ref: + - "_terms_enum.yaml#/thyroid_gland_isthmus/common" + Urethra: + $ref: + - "_terms_enum.yaml#/urethra/common" + Uterus: + $ref: + - "_terms_enum.yaml#/uterus_nos/common" + Vertebral Canal: + $ref: + - "_terms_enum.yaml#/vertebral_canal/common" + Vulva, NOS: + $ref: + - "_terms_enum.yaml#/vulva_nos/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + sites_of_involvement_count: + $ref: + - "_terms.yaml#/sites_of_involvement_count/common" + type: integer + minimum: 1 + + supratentorial_localization: + $ref: + - "_terms.yaml#/supratentorial_localization/common" + enum: + - Cerebral Cortex + - Deep Gray (e.g. Basal Ganglia, Thalamus) + - Frontal lobe + - Occipital lobe + - Parietal lobe + - Spinal Cord + - Temporal lobe + - White Matter + - Unknown + - Not Reported + enumDef: + Cerebral Cortex: + $ref: + - "_terms_enum.yaml#/cerebral_cortex/common" + Deep Gray (e.g. Basal Ganglia, Thalamus): + $ref: + - "_terms_enum.yaml#/deep_gray_eg_basal_ganglia_thalamus/common" + Frontal lobe: + $ref: + - "_terms_enum.yaml#/frontal_lobe/common" + Occipital lobe: + $ref: + - "_terms_enum.yaml#/occipital_lobe/common" + Parietal lobe: + $ref: + - "_terms_enum.yaml#/parietal_lobe/common" + Spinal Cord: + $ref: + - "_terms_enum.yaml#/spinal_cord/common" + Temporal lobe: + $ref: + - "_terms_enum.yaml#/temporal_lobe/common" + White Matter: + $ref: + - "_terms_enum.yaml#/white_matter/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + synchronous_malignancy: + $ref: + - "_terms.yaml#/synchronous_malignancy/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + tissue_or_organ_of_origin: + $ref: + - "_terms.yaml#/tissue_or_organ_of_origin/common" + enum: + - Abdomen, NOS + - Abdominal esophagus + - Accessory sinus, NOS + - Acoustic nerve + - Adrenal gland, NOS + - Ampulla of Vater + - Anal canal + - Anterior 2/3 of tongue, NOS + - Anterior floor of mouth + - Anterior mediastinum + - Anterior surface of epiglottis + - Anterior wall of bladder + - Anterior wall of nasopharynx + - Anus, NOS + - Aortic body and other paraganglia + - Appendix + - Ascending colon + - Autonomic nervous system, NOS + - Axillary tail of breast + - Base of tongue, NOS + - Biliary tract, NOS + - Bladder neck + - Bladder, NOS + - Blood + - Body of pancreas + - Body of penis + - Body of stomach + - Bone marrow + - Bone of limb, NOS + - Bone, NOS + - Bones of skull and face and associated joints + - Border of tongue + - Brain stem + - Brain, NOS + - Branchial cleft + - Breast, NOS + - Broad ligament + - Cardia, NOS + - Carotid body + - Cauda equina + - Cecum + - Central portion of breast + - Cerebellum, NOS + - Cerebral meninges + - Cerebrum + - Cervical esophagus + - Cervix uteri + - Cheek mucosa + - Choroid + - Ciliary body + - Clitoris + - Cloacogenic zone + - Colon, NOS + - Commissure of lip + - Conjunctiva + - Connective, subcutaneous and other soft tissues of abdomen + - Connective, subcutaneous and other soft tissues of head, face, and neck + - Connective, subcutaneous and other soft tissues of lower limb and hip + - Connective, subcutaneous and other soft tissues of pelvis + - Connective, subcutaneous and other soft tissues of thorax + - Connective, subcutaneous and other soft tissues of trunk, NOS + - Connective, subcutaneous and other soft tissues of upper limb and shoulder + - Connective, subcutaneous and other soft tissues, NOS + - Cornea, NOS + - Corpus uteri + - Cortex of adrenal gland + - Cranial nerve, NOS + - Craniopharyngeal duct + - Descended testis + - Descending colon + - Dome of bladder + - Dorsal surface of tongue, NOS + - Duodenum + - Endocervix + - Endocrine gland, NOS + - Endometrium + - Epididymis + - Esophagus, NOS + - Ethmoid sinus + - Exocervix + - External ear + - External lip, NOS + - External lower lip + - External upper lip + - Extrahepatic bile duct + - Eye, NOS + - Eyelid + - Fallopian tube + - Female genital tract, NOS + - Floor of mouth, NOS + - Frontal lobe + - Frontal sinus + - Fundus of stomach + - Fundus uteri + - Gallbladder + - Gastric antrum + - Gastrointestinal tract, NOS + - Glans penis + - Glottis + - Greater curvature of stomach, NOS + - Gum, NOS + - Hard palate + - Head of pancreas + - Head, face or neck, NOS + - Heart + - Hematopoietic system, NOS + - Hepatic flexure of colon + - Hypopharyngeal aspect of aryepiglottic fold + - Hypopharynx, NOS + - Ileum + - Ill-defined sites within respiratory system + - Intestinal tract, NOS + - Intra-abdominal lymph nodes + - Intrahepatic bile duct + - Intrathoracic lymph nodes + - Islets of Langerhans + - Isthmus uteri + - Jejunum + - Kidney, NOS + - Labium majus + - Labium minus + - Lacrimal gland + - Laryngeal cartilage + - Laryngeal commissure + - Larynx, NOS + - Lateral floor of mouth + - Lateral wall of bladder + - Lateral wall of nasopharynx + - Lateral wall of oropharynx + - Lesser curvature of stomach, NOS + - Lingual tonsil + - Lip, NOS + - Liver + - Long bones of lower limb and associated joints + - Long bones of upper limb, scapula and associated joints + - Lower gum + - Lower limb, NOS + - Lower lobe, lung + - Lower third of esophagus + - Lower-inner quadrant of breast + - Lower-outer quadrant of breast + - Lung, NOS + - Lymph node, NOS + - Lymph nodes of axilla or arm + - Lymph nodes of head, face and neck + - Lymph nodes of inguinal region or leg + - Lymph nodes of multiple regions + - Main bronchus + - Major salivary gland, NOS + - Male genital organs, NOS + - Mandible + - Maxillary sinus + - Meckel diverticulum + - Mediastinum, NOS + - Medulla of adrenal gland + - Meninges, NOS + - Middle ear + - Middle lobe, lung + - Middle third of esophagus + - Mouth, NOS + - Mucosa of lip, NOS + - Mucosa of lower lip + - Mucosa of upper lip + - Myometrium + - Nasal cavity + - Nasopharynx, NOS + - Nervous system, NOS + - Nipple + - Occipital lobe + - Olfactory nerve + - Optic nerve + - Orbit, NOS + - Oropharynx, NOS + - Other ill-defined sites + - Other specified parts of female genital organs + - Other specified parts of male genital organs + - Other specified parts of pancreas + - Ovary + - Overlapping lesion of accessory sinuses + - Overlapping lesion of biliary tract + - Overlapping lesion of bladder + - Overlapping lesion of bones, joints and articular cartilage + - Overlapping lesion of bones, joints and articular cartilage of limbs + - Overlapping lesion of brain + - Overlapping lesion of brain and central nervous system + - Overlapping lesion of breast + - Overlapping lesion of cervix uteri + - Overlapping lesion of colon + - Overlapping lesion of connective, subcutaneous and other soft tissues + - Overlapping lesion of corpus uteri + - Overlapping lesion of digestive system + - Overlapping lesion of endocrine glands and related structures + - Overlapping lesion of esophagus + - Overlapping lesion of eye and adnexa + - Overlapping lesion of female genital organs + - Overlapping lesion of floor of mouth + - Overlapping lesion of heart, mediastinum and pleura + - Overlapping lesion of hypopharynx + - Overlapping lesion of ill-defined sites + - Overlapping lesion of larynx + - Overlapping lesion of lip + - Overlapping lesion of lip, oral cavity and pharynx + - Overlapping lesion of lung + - Overlapping lesion of major salivary glands + - Overlapping lesion of male genital organs + - Overlapping lesion of nasopharynx + - Overlapping lesion of other and unspecified parts of mouth + - Overlapping lesion of palate + - Overlapping lesion of pancreas + - Overlapping lesion of penis + - Overlapping lesion of peripheral nerves and autonomic nervous system + - Overlapping lesion of rectum, anus and anal canal + - Overlapping lesion of respiratory system and intrathoracic organs + - Overlapping lesion of retroperitoneum and peritoneum + - Overlapping lesion of skin + - Overlapping lesion of small intestine + - Overlapping lesion of stomach + - Overlapping lesion of tongue + - Overlapping lesion of tonsil + - Overlapping lesion of urinary organs + - Overlapping lesion of vulva + - Overlapping lesions of oropharynx + - Palate, NOS + - Pancreas, NOS + - Pancreatic duct + - Parametrium + - Parathyroid gland + - Paraurethral gland + - Parietal lobe + - Parotid gland + - Pelvic bones, sacrum, coccyx and associated joints + - Pelvic lymph nodes + - Pelvis, NOS + - Penis, NOS + - Peripheral nerves and autonomic nervous system of abdomen + - Peripheral nerves and autonomic nervous system of head, face, and neck + - Peripheral nerves and autonomic nervous system of lower limb and hip + - Peripheral nerves and autonomic nervous system of pelvis + - Peripheral nerves and autonomic nervous system of thorax + - Peripheral nerves and autonomic nervous system of trunk, NOS + - Peripheral nerves and autonomic nervous system of upper limb and shoulder + - Peritoneum, NOS + - Pharynx, NOS + - Pineal gland + - Pituitary gland + - Placenta + - Pleura, NOS + - Postcricoid region + - Posterior mediastinum + - Posterior wall of bladder + - Posterior wall of hypopharynx + - Posterior wall of nasopharynx + - Posterior wall of oropharynx + - Prepuce + - Prostate gland + - Pylorus + - Pyriform sinus + - Rectosigmoid junction + - Rectum, NOS + - Renal pelvis + - Reticuloendothelial system, NOS + - Retina + - Retromolar area + - Retroperitoneum + - Rib, sternum, clavicle and associated joints + - Round ligament + - Scrotum, NOS + - Short bones of lower limb and associated joints + - Short bones of upper limb and associated joints + - Sigmoid colon + - Skin of lip, NOS + - Skin of lower limb and hip + - Skin of other and unspecified parts of face + - Skin of scalp and neck + - Skin of trunk + - Skin of upper limb and shoulder + - Skin, NOS + - Small intestine, NOS + - Soft palate, NOS + - Specified parts of peritoneum + - Spermatic cord + - Sphenoid sinus + - Spinal cord + - Spinal meninges + - Spleen + - Splenic flexure of colon + - Stomach, NOS + - Subglottis + - Sublingual gland + - Submandibular gland + - Superior wall of nasopharynx + - Supraglottis + - Tail of pancreas + - Temporal lobe + - Testis, NOS + - Thoracic esophagus + - Thorax, NOS + - Thymus + - Thyroid gland + - Tongue, NOS + - Tonsil, NOS + - Tonsillar fossa + - Tonsillar pillar + - Trachea + - Transverse colon + - Trigone of bladder + - Undescended testis + - Unknown primary site + - Upper Gum + - Upper limb, NOS + - Upper lobe, lung + - Upper respiratory tract, NOS + - Upper third of esophagus + - Upper-inner quadrant of breast + - Upper-outer quadrant of breast + - Urachus + - Ureter + - Ureteric orifice + - Urethra + - Urinary system, NOS + - Uterine adnexa + - Uterus, NOS + - Uvula + - Vagina, NOS + - Vallecula + - Ventral surface of tongue, NOS + - Ventricle, NOS + - Vertebral column + - Vestibule of mouth + - Vulva, NOS + - Waldeyer ring + - Unknown + - Not Reported + enumDef: + Abdomen, NOS: + $ref: + - "_terms_enum.yaml#/abdomen_nos/common" + Abdominal esophagus: + $ref: + - "_terms_enum.yaml#/abdominal_esophagus/common" + Accessory sinus, NOS: + $ref: + - "_terms_enum.yaml#/accessory_sinus_nos/common" + Acoustic nerve: + $ref: + - "_terms_enum.yaml#/acoustic_nerve/common" + Adrenal gland, NOS: + $ref: + - "_terms_enum.yaml#/adrenal_gland_nos/common" + Ampulla of Vater: + $ref: + - "_terms_enum.yaml#/ampulla_of_vater/common" + Anal canal: + $ref: + - "_terms_enum.yaml#/anal_canal/common" + Anterior mediastinum: + $ref: + - "_terms_enum.yaml#/anterior_mediastinum/common" + Anterior surface of epiglottis: + $ref: + - "_terms_enum.yaml#/anterior_surface_of_epiglottis/common" + Anterior wall of bladder: + $ref: + - "_terms_enum.yaml#/anterior_wall_of_bladder/common" + Anterior wall of nasopharynx: + $ref: + - "_terms_enum.yaml#/anterior_wall_of_nasopharynx/common" + Anus, NOS: + $ref: + - "_terms_enum.yaml#/anus_nos/common" + Appendix: + $ref: + - "_terms_enum.yaml#/appendix/common" + Ascending colon: + $ref: + - "_terms_enum.yaml#/ascending_colon/common" + Autonomic nervous system, NOS: + $ref: + - "_terms_enum.yaml#/autonomic_nervous_system_nos/common" + Axillary tail of breast: + $ref: + - "_terms_enum.yaml#/axillary_tail_of_breast/common" + Base of tongue, NOS: + $ref: + - "_terms_enum.yaml#/base_of_tongue_nos/common" + Biliary tract, NOS: + $ref: + - "_terms_enum.yaml#/biliary_tract_nos/common" + Bladder neck: + $ref: + - "_terms_enum.yaml#/bladder_neck/common" + Bladder, NOS: + $ref: + - "_terms_enum.yaml#/bladder_nos/common" + Blood: + $ref: + - "_terms_enum.yaml#/blood/common" + Body of pancreas: + $ref: + - "_terms_enum.yaml#/body_of_pancreas/common" + Body of penis: + $ref: + - "_terms_enum.yaml#/body_of_penis/common" + Body of stomach: + $ref: + - "_terms_enum.yaml#/body_of_stomach/common" + Bone marrow: + $ref: + - "_terms_enum.yaml#/bone_marrow/common" + Bone of limb, NOS: + $ref: + - "_terms_enum.yaml#/bone_of_limb_nos/common" + Bone, NOS: + $ref: + - "_terms_enum.yaml#/bone_nos/common" + Brain stem: + $ref: + - "_terms_enum.yaml#/brain_stem/common" + Brain, NOS: + $ref: + - "_terms_enum.yaml#/brain_nos/common" + Branchial cleft: + $ref: + - "_terms_enum.yaml#/branchial_cleft/common" + Breast, NOS: + $ref: + - "_terms_enum.yaml#/breast_nos/common" + Broad ligament: + $ref: + - "_terms_enum.yaml#/broad_ligament/common" + Cardia, NOS: + $ref: + - "_terms_enum.yaml#/cardia_nos/common" + Carotid body: + $ref: + - "_terms_enum.yaml#/carotid_body/common" + Cauda equina: + $ref: + - "_terms_enum.yaml#/cauda_equina/common" + Cecum: + $ref: + - "_terms_enum.yaml#/cecum/common" + Central portion of breast: + $ref: + - "_terms_enum.yaml#/central_portion_of_breast/common" + Cerebellum, NOS: + $ref: + - "_terms_enum.yaml#/cerebellum_nos/common" + Cerebral meninges: + $ref: + - "_terms_enum.yaml#/cerebral_meninges/common" + Cerebrum: + $ref: + - "_terms_enum.yaml#/cerebrum/common" + Cervical esophagus: + $ref: + - "_terms_enum.yaml#/cervical_esophagus/common" + Cervix uteri: + $ref: + - "_terms_enum.yaml#/cervix_uteri/common" + Cheek mucosa: + $ref: + - "_terms_enum.yaml#/cheek_mucosa/common" + Choroid: + $ref: + - "_terms_enum.yaml#/choroid/common" + Ciliary body: + $ref: + - "_terms_enum.yaml#/ciliary_body/common" + Clitoris: + $ref: + - "_terms_enum.yaml#/clitoris/common" + Cloacogenic zone: + $ref: + - "_terms_enum.yaml#/cloacogenic_zone/common" + Colon, NOS: + $ref: + - "_terms_enum.yaml#/colon_nos/common" + Commissure of lip: + $ref: + - "_terms_enum.yaml#/commissure_of_lip/common" + Conjunctiva: + $ref: + - "_terms_enum.yaml#/conjunctiva/common" + Cornea, NOS: + $ref: + - "_terms_enum.yaml#/cornea_nos/common" + Corpus uteri: + $ref: + - "_terms_enum.yaml#/corpus_uteri/common" + Cortex of adrenal gland: + $ref: + - "_terms_enum.yaml#/cortex_of_adrenal_gland/common" + Cranial nerve, NOS: + $ref: + - "_terms_enum.yaml#/cranial_nerve_nos/common" + Craniopharyngeal duct: + $ref: + - "_terms_enum.yaml#/craniopharyngeal_duct/common" + Descending colon: + $ref: + - "_terms_enum.yaml#/descending_colon/common" + Dome of bladder: + $ref: + - "_terms_enum.yaml#/dome_of_bladder/common" + Duodenum: + $ref: + - "_terms_enum.yaml#/duodenum/common" + Endocervix: + $ref: + - "_terms_enum.yaml#/endocervix/common" + Endocrine gland, NOS: + $ref: + - "_terms_enum.yaml#/endocrine_gland_nos/common" + Endometrium: + $ref: + - "_terms_enum.yaml#/endometrium/common" + Epididymis: + $ref: + - "_terms_enum.yaml#/epididymis/common" + Esophagus, NOS: + $ref: + - "_terms_enum.yaml#/esophagus_nos/common" + Ethmoid sinus: + $ref: + - "_terms_enum.yaml#/ethmoid_sinus/common" + Exocervix: + $ref: + - "_terms_enum.yaml#/exocervix/common" + External ear: + $ref: + - "_terms_enum.yaml#/external_ear/common" + External lip, NOS: + $ref: + - "_terms_enum.yaml#/external_lip_nos/common" + External lower lip: + $ref: + - "_terms_enum.yaml#/external_lower_lip/common" + External upper lip: + $ref: + - "_terms_enum.yaml#/external_upper_lip/common" + Extrahepatic bile duct: + $ref: + - "_terms_enum.yaml#/extrahepatic_bile_duct/common" + Eye, NOS: + $ref: + - "_terms_enum.yaml#/eye_nos/common" + Eyelid: + $ref: + - "_terms_enum.yaml#/eyelid/common" + Fallopian tube: + $ref: + - "_terms_enum.yaml#/fallopian_tube/common" + Female genital tract, NOS: + $ref: + - "_terms_enum.yaml#/female_genital_tract_nos/common" + Floor of mouth, NOS: + $ref: + - "_terms_enum.yaml#/floor_of_mouth_nos/common" + Frontal lobe: + $ref: + - "_terms_enum.yaml#/frontal_lobe/common" + Frontal sinus: + $ref: + - "_terms_enum.yaml#/frontal_sinus/common" + Fundus of stomach: + $ref: + - "_terms_enum.yaml#/fundus_of_stomach/common" + Fundus uteri: + $ref: + - "_terms_enum.yaml#/fundus_uteri/common" + Gallbladder: + $ref: + - "_terms_enum.yaml#/gallbladder/common" + Gastric antrum: + $ref: + - "_terms_enum.yaml#/gastric_antrum/common" + Gastrointestinal tract, NOS: + $ref: + - "_terms_enum.yaml#/gastrointestinal_tract_nos/common" + Glans penis: + $ref: + - "_terms_enum.yaml#/glans_penis/common" + Glottis: + $ref: + - "_terms_enum.yaml#/glottis/common" + Greater curvature of stomach, NOS: + $ref: + - "_terms_enum.yaml#/greater_curvature_of_stomach_nos/common" + Gum, NOS: + $ref: + - "_terms_enum.yaml#/gum_nos/common" + Hard palate: + $ref: + - "_terms_enum.yaml#/hard_palate/common" + Head of pancreas: + $ref: + - "_terms_enum.yaml#/head_of_pancreas/common" + Heart: + $ref: + - "_terms_enum.yaml#/heart/common" + Hematopoietic system, NOS: + $ref: + - "_terms_enum.yaml#/hematopoietic_system_nos/common" + Hepatic flexure of colon: + $ref: + - "_terms_enum.yaml#/hepatic_flexure_of_colon/common" + Hypopharynx, NOS: + $ref: + - "_terms_enum.yaml#/hypopharynx_nos/common" + Ileum: + $ref: + - "_terms_enum.yaml#/ileum/common" + Ill-defined sites within respiratory system: + $ref: + - "_terms_enum.yaml#/illdefined_sites_within_respiratory_system/common" + Intestinal tract, NOS: + $ref: + - "_terms_enum.yaml#/intestinal_tract_nos/common" + Intra-abdominal lymph nodes: + $ref: + - "_terms_enum.yaml#/intraabdominal_lymph_nodes/common" + Intrahepatic bile duct: + $ref: + - "_terms_enum.yaml#/intrahepatic_bile_duct/common" + Intrathoracic lymph nodes: + $ref: + - "_terms_enum.yaml#/intrathoracic_lymph_nodes/common" + Islets of Langerhans: + $ref: + - "_terms_enum.yaml#/islets_of_langerhans/common" + Isthmus uteri: + $ref: + - "_terms_enum.yaml#/isthmus_uteri/common" + Jejunum: + $ref: + - "_terms_enum.yaml#/jejunum/common" + Kidney, NOS: + $ref: + - "_terms_enum.yaml#/kidney_nos/common" + Labium majus: + $ref: + - "_terms_enum.yaml#/labium_majus/common" + Labium minus: + $ref: + - "_terms_enum.yaml#/labium_minus/common" + Lacrimal gland: + $ref: + - "_terms_enum.yaml#/lacrimal_gland/common" + Laryngeal cartilage: + $ref: + - "_terms_enum.yaml#/laryngeal_cartilage/common" + Larynx, NOS: + $ref: + - "_terms_enum.yaml#/larynx_nos/common" + Lateral wall of bladder: + $ref: + - "_terms_enum.yaml#/lateral_wall_of_bladder/common" + Lateral wall of nasopharynx: + $ref: + - "_terms_enum.yaml#/lateral_wall_of_nasopharynx/common" + Lateral wall of oropharynx: + $ref: + - "_terms_enum.yaml#/lateral_wall_of_oropharynx/common" + Lesser curvature of stomach, NOS: + $ref: + - "_terms_enum.yaml#/lesser_curvature_of_stomach_nos/common" + Lingual tonsil: + $ref: + - "_terms_enum.yaml#/lingual_tonsil/common" + Lip, NOS: + $ref: + - "_terms_enum.yaml#/lip_nos/common" + Liver: + $ref: + - "_terms_enum.yaml#/liver/common" + Lower gum: + $ref: + - "_terms_enum.yaml#/lower_gum/common" + Lower limb, NOS: + $ref: + - "_terms_enum.yaml#/lower_limb_nos/common" + Lower lobe, lung: + $ref: + - "_terms_enum.yaml#/lower_lobe_lung/common" + Lower third of esophagus: + $ref: + - "_terms_enum.yaml#/lower_third_of_esophagus/common" + Lower-inner quadrant of breast: + $ref: + - "_terms_enum.yaml#/lowerinner_quadrant_of_breast/common" + Lower-outer quadrant of breast: + $ref: + - "_terms_enum.yaml#/lowerouter_quadrant_of_breast/common" + Lung, NOS: + $ref: + - "_terms_enum.yaml#/lung_nos/common" + Lymph node, NOS: + $ref: + - "_terms_enum.yaml#/lymph_node_nos/common" + Lymph nodes of axilla or arm: + $ref: + - "_terms_enum.yaml#/lymph_nodes_of_axilla_or_arm/common" + Lymph nodes of head, face and neck: + $ref: + - "_terms_enum.yaml#/lymph_nodes_of_head_face_and_neck/common" + Lymph nodes of inguinal region or leg: + $ref: + - "_terms_enum.yaml#/lymph_nodes_of_inguinal_region_or_leg/common" + Main bronchus: + $ref: + - "_terms_enum.yaml#/main_bronchus/common" + Major salivary gland, NOS: + $ref: + - "_terms_enum.yaml#/major_salivary_gland_nos/common" + Male genital organs, NOS: + $ref: + - "_terms_enum.yaml#/male_genital_organs_nos/common" + Mandible: + $ref: + - "_terms_enum.yaml#/mandible/common" + Maxillary sinus: + $ref: + - "_terms_enum.yaml#/maxillary_sinus/common" + Meckel diverticulum: + $ref: + - "_terms_enum.yaml#/meckel_diverticulum/common" + Mediastinum, NOS: + $ref: + - "_terms_enum.yaml#/mediastinum_nos/common" + Medulla of adrenal gland: + $ref: + - "_terms_enum.yaml#/medulla_of_adrenal_gland/common" + Meninges, NOS: + $ref: + - "_terms_enum.yaml#/meninges_nos/common" + Middle ear: + $ref: + - "_terms_enum.yaml#/middle_ear/common" + Middle lobe, lung: + $ref: + - "_terms_enum.yaml#/middle_lobe_lung/common" + Middle third of esophagus: + $ref: + - "_terms_enum.yaml#/middle_third_of_esophagus/common" + Mouth, NOS: + $ref: + - "_terms_enum.yaml#/mouth_nos/common" + Mucosa of lip, NOS: + $ref: + - "_terms_enum.yaml#/mucosa_of_lip_nos/common" + Mucosa of lower lip: + $ref: + - "_terms_enum.yaml#/mucosa_of_lower_lip/common" + Mucosa of upper lip: + $ref: + - "_terms_enum.yaml#/mucosa_of_upper_lip/common" + Myometrium: + $ref: + - "_terms_enum.yaml#/myometrium/common" + Nasal cavity: + $ref: + - "_terms_enum.yaml#/nasal_cavity/common" + Nasopharynx, NOS: + $ref: + - "_terms_enum.yaml#/nasopharynx_nos/common" + Nervous system, NOS: + $ref: + - "_terms_enum.yaml#/nervous_system_nos/common" + Nipple: + $ref: + - "_terms_enum.yaml#/nipple/common" + Occipital lobe: + $ref: + - "_terms_enum.yaml#/occipital_lobe/common" + Olfactory nerve: + $ref: + - "_terms_enum.yaml#/olfactory_nerve/common" + Optic nerve: + $ref: + - "_terms_enum.yaml#/optic_nerve/common" + Orbit, NOS: + $ref: + - "_terms_enum.yaml#/orbit_nos/common" + Oropharynx, NOS: + $ref: + - "_terms_enum.yaml#/oropharynx_nos/common" + Other ill-defined sites: + $ref: + - "_terms_enum.yaml#/other_illdefined_sites/common" + Other specified parts of female genital organs: + $ref: + - "_terms_enum.yaml#/other_specified_parts_of_female_genital_organs/common" + Other specified parts of male genital organs: + $ref: + - "_terms_enum.yaml#/other_specified_parts_of_male_genital_organs/common" + Other specified parts of pancreas: + $ref: + - "_terms_enum.yaml#/other_specified_parts_of_pancreas/common" + Ovary: + $ref: + - "_terms_enum.yaml#/ovary/common" + Palate, NOS: + $ref: + - "_terms_enum.yaml#/palate_nos/common" + Pancreas, NOS: + $ref: + - "_terms_enum.yaml#/pancreas_nos/common" + Pancreatic duct: + $ref: + - "_terms_enum.yaml#/pancreatic_duct/common" + Parametrium: + $ref: + - "_terms_enum.yaml#/parametrium/common" + Parathyroid gland: + $ref: + - "_terms_enum.yaml#/parathyroid_gland/common" + Paraurethral gland: + $ref: + - "_terms_enum.yaml#/paraurethral_gland/common" + Parietal lobe: + $ref: + - "_terms_enum.yaml#/parietal_lobe/common" + Parotid gland: + $ref: + - "_terms_enum.yaml#/parotid_gland/common" + Pelvic lymph nodes: + $ref: + - "_terms_enum.yaml#/pelvic_lymph_nodes/common" + Pelvis, NOS: + $ref: + - "_terms_enum.yaml#/pelvis_nos/common" + Penis, NOS: + $ref: + - "_terms_enum.yaml#/penis_nos/common" + Peritoneum, NOS: + $ref: + - "_terms_enum.yaml#/peritoneum_nos/common" + Pharynx, NOS: + $ref: + - "_terms_enum.yaml#/pharynx_nos/common" + Pineal gland: + $ref: + - "_terms_enum.yaml#/pineal_gland/common" + Pituitary gland: + $ref: + - "_terms_enum.yaml#/pituitary_gland/common" + Placenta: + $ref: + - "_terms_enum.yaml#/placenta/common" + Pleura, NOS: + $ref: + - "_terms_enum.yaml#/pleura_nos/common" + Postcricoid region: + $ref: + - "_terms_enum.yaml#/postcricoid_region/common" + Posterior mediastinum: + $ref: + - "_terms_enum.yaml#/posterior_mediastinum/common" + Posterior wall of bladder: + $ref: + - "_terms_enum.yaml#/posterior_wall_of_bladder/common" + Posterior wall of hypopharynx: + $ref: + - "_terms_enum.yaml#/posterior_wall_of_hypopharynx/common" + Posterior wall of nasopharynx: + $ref: + - "_terms_enum.yaml#/posterior_wall_of_nasopharynx/common" + Posterior wall of oropharynx: + $ref: + - "_terms_enum.yaml#/posterior_wall_of_oropharynx/common" + Prepuce: + $ref: + - "_terms_enum.yaml#/prepuce/common" + Prostate gland: + $ref: + - "_terms_enum.yaml#/prostate_gland/common" + Pylorus: + $ref: + - "_terms_enum.yaml#/pylorus/common" + Pyriform sinus: + $ref: + - "_terms_enum.yaml#/pyriform_sinus/common" + Rectosigmoid junction: + $ref: + - "_terms_enum.yaml#/rectosigmoid_junction/common" + Rectum, NOS: + $ref: + - "_terms_enum.yaml#/rectum_nos/common" + Renal pelvis: + $ref: + - "_terms_enum.yaml#/renal_pelvis/common" + Reticuloendothelial system, NOS: + $ref: + - "_terms_enum.yaml#/reticuloendothelial_system_nos/common" + Retina: + $ref: + - "_terms_enum.yaml#/retina/common" + Retromolar area: + $ref: + - "_terms_enum.yaml#/retromolar_area/common" + Retroperitoneum: + $ref: + - "_terms_enum.yaml#/retroperitoneum/common" + Round ligament: + $ref: + - "_terms_enum.yaml#/round_ligament/common" + Scrotum, NOS: + $ref: + - "_terms_enum.yaml#/scrotum_nos/common" + Sigmoid colon: + $ref: + - "_terms_enum.yaml#/sigmoid_colon/common" + Skin of lip, NOS: + $ref: + - "_terms_enum.yaml#/skin_of_lip_nos/common" + Skin of lower limb and hip: + $ref: + - "_terms_enum.yaml#/skin_of_lower_limb_and_hip/common" + Skin of other and unspecified parts of face: + $ref: + - "_terms_enum.yaml#/skin_of_other_and_unspecified_parts_of_face/common" + Skin of scalp and neck: + $ref: + - "_terms_enum.yaml#/skin_of_scalp_and_neck/common" + Skin of trunk: + $ref: + - "_terms_enum.yaml#/skin_of_trunk/common" + Skin of upper limb and shoulder: + $ref: + - "_terms_enum.yaml#/skin_of_upper_limb_and_shoulder/common" + Skin, NOS: + $ref: + - "_terms_enum.yaml#/skin_nos/common" + Small intestine, NOS: + $ref: + - "_terms_enum.yaml#/small_intestine_nos/common" + Soft palate, NOS: + $ref: + - "_terms_enum.yaml#/soft_palate_nos/common" + Spermatic cord: + $ref: + - "_terms_enum.yaml#/spermatic_cord/common" + Sphenoid sinus: + $ref: + - "_terms_enum.yaml#/sphenoid_sinus/common" + Spinal cord: + $ref: + - "_terms_enum.yaml#/spinal_cord/common" + Spinal meninges: + $ref: + - "_terms_enum.yaml#/spinal_meninges/common" + Spleen: + $ref: + - "_terms_enum.yaml#/spleen/common" + Splenic flexure of colon: + $ref: + - "_terms_enum.yaml#/splenic_flexure_of_colon/common" + Stomach, NOS: + $ref: + - "_terms_enum.yaml#/stomach_nos/common" + Subglottis: + $ref: + - "_terms_enum.yaml#/subglottis/common" + Sublingual gland: + $ref: + - "_terms_enum.yaml#/sublingual_gland/common" + Submandibular gland: + $ref: + - "_terms_enum.yaml#/submandibular_gland/common" + Superior wall of nasopharynx: + $ref: + - "_terms_enum.yaml#/superior_wall_of_nasopharynx/common" + Supraglottis: + $ref: + - "_terms_enum.yaml#/supraglottis/common" + Tail of pancreas: + $ref: + - "_terms_enum.yaml#/tail_of_pancreas/common" + Temporal lobe: + $ref: + - "_terms_enum.yaml#/temporal_lobe/common" + Testis, NOS: + $ref: + - "_terms_enum.yaml#/testis_nos/common" + Thoracic esophagus: + $ref: + - "_terms_enum.yaml#/thoracic_esophagus/common" + Thorax, NOS: + $ref: + - "_terms_enum.yaml#/thorax_nos/common" + Thymus: + $ref: + - "_terms_enum.yaml#/thymus/common" + Thyroid gland: + $ref: + - "_terms_enum.yaml#/thyroid_gland/common" + Tongue, NOS: + $ref: + - "_terms_enum.yaml#/tongue_nos/common" + Tonsil, NOS: + $ref: + - "_terms_enum.yaml#/tonsil_nos/common" + Tonsillar fossa: + $ref: + - "_terms_enum.yaml#/tonsillar_fossa/common" + Tonsillar pillar: + $ref: + - "_terms_enum.yaml#/tonsillar_pillar/common" + Trachea: + $ref: + - "_terms_enum.yaml#/trachea/common" + Transverse colon: + $ref: + - "_terms_enum.yaml#/transverse_colon/common" + Trigone of bladder: + $ref: + - "_terms_enum.yaml#/trigone_of_bladder/common" + Undescended testis: + $ref: + - "_terms_enum.yaml#/undescended_testis/common" + Unknown primary site: + $ref: + - "_terms_enum.yaml#/unknown_primary_site/common" + Upper Gum: + $ref: + - "_terms_enum.yaml#/upper_gum/common" + Upper limb, NOS: + $ref: + - "_terms_enum.yaml#/upper_limb_nos/common" + Upper lobe, lung: + $ref: + - "_terms_enum.yaml#/upper_lobe_lung/common" + Upper respiratory tract, NOS: + $ref: + - "_terms_enum.yaml#/upper_respiratory_tract_nos/common" + Upper third of esophagus: + $ref: + - "_terms_enum.yaml#/upper_third_of_esophagus/common" + Upper-inner quadrant of breast: + $ref: + - "_terms_enum.yaml#/upperinner_quadrant_of_breast/common" + Upper-outer quadrant of breast: + $ref: + - "_terms_enum.yaml#/upperouter_quadrant_of_breast/common" + Urachus: + $ref: + - "_terms_enum.yaml#/urachus/common" + Ureter: + $ref: + - "_terms_enum.yaml#/ureter/common" + Ureteric orifice: + $ref: + - "_terms_enum.yaml#/ureteric_orifice/common" + Urethra: + $ref: + - "_terms_enum.yaml#/urethra/common" + Urinary system, NOS: + $ref: + - "_terms_enum.yaml#/urinary_system_nos/common" + Uterine adnexa: + $ref: + - "_terms_enum.yaml#/uterine_adnexa/common" + Uterus, NOS: + $ref: + - "_terms_enum.yaml#/uterus_nos/common" + Uvula: + $ref: + - "_terms_enum.yaml#/uvula/common" + Vagina, NOS: + $ref: + - "_terms_enum.yaml#/vagina_nos/common" + Vallecula: + $ref: + - "_terms_enum.yaml#/vallecula/common" + Ventricle, NOS: + $ref: + - "_terms_enum.yaml#/ventricle_nos/common" + Vertebral column: + $ref: + - "_terms_enum.yaml#/vertebral_column/common" + Vestibule of mouth: + $ref: + - "_terms_enum.yaml#/vestibule_of_mouth/common" + Vulva, NOS: + $ref: + - "_terms_enum.yaml#/vulva_nos/common" + Waldeyer ring: + $ref: + - "_terms_enum.yaml#/waldeyer_ring/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + tumor_burden: + $ref: + - "_terms.yaml#/tumor_burden/common" + type: number + minimum: 0 + + tumor_confined_to_organ_of_origin: + $ref: + - "_terms.yaml#/tumor_confined_to_organ_of_origin/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + tumor_depth: + $ref: + - "_terms.yaml#/tumor_depth/common" + type: number + minimum: 0 + + tumor_focality: + $ref: + - "_terms.yaml#/tumor_focality/common" + enum: + - Multifocal + - Unifocal + - Unknown + - Not Reported + enumDef: + Multifocal: + $ref: + - "_terms_enum.yaml#/multifocal/common" + Unifocal: + $ref: + - "_terms_enum.yaml#/unifocal/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + tumor_grade: + $ref: + - "_terms.yaml#/tumor_grade/common" + enum: + - G1 + - G2 + - G3 + - G4 + - GB + - GX + - High Grade + - Intermediate Grade + - Low Grade + - Unknown + - Not Reported + enumDef: + G1: + $ref: + - "_terms_enum.yaml#/g1/common" + G2: + $ref: + - "_terms_enum.yaml#/g2/common" + G3: + $ref: + - "_terms_enum.yaml#/g3/common" + G4: + $ref: + - "_terms_enum.yaml#/g4/common" + GB: + $ref: + - "_terms_enum.yaml#/gb/common" + GX: + $ref: + - "_terms_enum.yaml#/gx/common" + High Grade: + $ref: + - "_terms_enum.yaml#/high_grade/common" + Intermediate Grade: + $ref: + - "_terms_enum.yaml#/intermediate_grade/common" + Low Grade: + $ref: + - "_terms_enum.yaml#/low_grade/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + tumor_grade_category: + $ref: + - "_terms.yaml#/tumor_grade_category/common" + enum: + - Four Tier + - Three Tier + - Unknown + - Not Reported + + tumor_of_origin: + $ref: + - "_terms.yaml#/tumor_of_origin/common" + type: string + + tumor_regression_grade: + $ref: + - "_terms.yaml#/tumor_regression_grade/common" + enum: + - "0" + - "1" + - "2" + - "3" + - Unknown + - Not Reported + enumDef: + "0": + $ref: + - "_terms_enum.yaml#/0/diagnosis/tumor_regression_grade" + "1": + $ref: + - "_terms_enum.yaml#/1/diagnosis/tumor_regression_grade" + "2": + $ref: + - "_terms_enum.yaml#/2/diagnosis/tumor_regression_grade" + "3": + $ref: + - "_terms_enum.yaml#/3/diagnosis/tumor_regression_grade" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + uicc_clinical_m: + $ref: + - "_terms.yaml#/uicc_clinical_m/common" + enum: + - cM0 (i+) + - M0 + - M1 + - M1a + - M1b + - M1c + - MX + - Unknown + - Not Reported + + uicc_clinical_n: + $ref: + - "_terms.yaml#/uicc_clinical_n/common" + enum: + - N0 + - N0 (i+) + - N0 (i-) + - N0 (mol+) + - N0 (mol-) + - N1 + - N1a + - N1b + - N1bI + - N1bII + - N1bIII + - N1bIV + - N1c + - N1mi + - N2 + - N2a + - N2b + - N2c + - N3 + - N3a + - N3b + - N3c + - N4 + - NX + - Unknown + - Not Reported + + uicc_clinical_stage: + $ref: + - "_terms.yaml#/uicc_clinical_stage/common" + enum: + - Stage 0 + - Stage 0a + - Stage 0is + - Stage I + - Stage IA + - Stage IA1 + - Stage IA2 + - Stage IA3 + - Stage IB + - Stage IB1 + - Stage IB2 + - Stage IC + - Stage II + - Stage IIA + - Stage IIA1 + - Stage IIA2 + - Stage IIB + - Stage IIC + - Stage IIC1 + - Stage III + - Stage IIIA + - Stage IIIB + - Stage IIIC + - Stage IIIC1 + - Stage IIIC2 + - Stage IS + - Stage IV + - Stage IVA + - Stage IVB + - Stage IVC + - Stage Tis + - Stage X + - Unknown + - Not Reported + + uicc_clinical_t: + $ref: + - "_terms.yaml#/uicc_clinical_t/common" + enum: + - T0 + - T1 + - T1a + - T1a1 + - T1a2 + - T1b + - T1b1 + - T1b2 + - T1c + - T1mi + - T2 + - T2a + - T2a1 + - T2a2 + - T2b + - T2c + - T2d + - T3 + - T3a + - T3b + - T3c + - T3d + - T4 + - T4a + - T4b + - T4c + - T4d + - T4e + - Ta + - Tis + - Tis (DCIS) + - Tis (LCIS) + - Tis (Paget's) + - TX + - Unknown + - Not Reported + + uicc_pathologic_m: + $ref: + - "_terms.yaml#/uicc_pathologic_m/common" + enum: + - cM0 (i+) + - M0 + - M1 + - M1a + - M1b + - M1c + - M1d + - M2 + - MX + - Unknown + - Not Reported + + uicc_pathologic_n: + $ref: + - "_terms.yaml#/uicc_pathologic_n/common" + enum: + - N0 + - N0 (i+) + - N0 (i-) + - N0 (mol+) + - N0 (mol-) + - N1 + - N1a + - N1b + - N1bI + - N1bII + - N1bIII + - N1bIV + - N1c + - N1mi + - N2 + - N2a + - N2b + - N2c + - N2mi + - N3 + - N3a + - N3b + - N3c + - N4 + - NX + - Unknown + - Not Reported + + uicc_pathologic_stage: + $ref: + - "_terms.yaml#/uicc_pathologic_stage/common" + enum: + - Stage 0 + - Stage 0a + - Stage 0is + - Stage I + - Stage IA + - Stage IA1 + - Stage IA2 + - Stage IA3 + - Stage IB + - Stage IB1 + - Stage IB2 + - Stage IC + - Stage II + - Stage IIA + - Stage IIA1 + - Stage IIA2 + - Stage IIB + - Stage IIC + - Stage III + - Stage IIIA + - Stage IIIA1 + - Stage IIIA2 + - Stage IIIB + - Stage IIIC + - Stage IIIC1 + - Stage IIIC2 + - Stage IIID + - Stage IS + - Stage IV + - Stage IVA + - Stage IVB + - Stage IVC + - Stage Tis + - Stage X + - Unknown + - Not Reported + + uicc_pathologic_t: + $ref: + - "_terms.yaml#/uicc_pathologic_t/common" + enum: + - T0 + - T1 + - T1a + - T1a1 + - T1a2 + - T1b + - T1b1 + - T1b2 + - T1c + - T1c2 + - T1mi + - T2 + - T2a + - T2a1 + - T2a2 + - T2b + - T2c + - T2d + - T3 + - T3a + - T3b + - T3c + - T3d + - T4 + - T4a + - T4b + - T4c + - T4d + - T4e + - Ta + - Tis + - Tis (DCIS) + - Tis (LCIS) + - Tis (Paget's) + - TX + - Unknown + - Not Reported + + uicc_staging_system_edition: + $ref: + - "_terms.yaml#/uicc_staging_system_edition/common" + enum: + - 1st + - 2nd + - 3rd + - 4th + - 5th + - 6th + - 7th + - 8th + - Unknown + - Not Reported + + ulceration_indicator: + $ref: + - "_terms.yaml#/ulceration_indicator/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + weiss_assessment_findings: + $ref: + - "_terms.yaml#/weiss_assessment_findings/common" + type: array + items: + enum: + - Atypical Mitotic Figures + - Cytoplasm presence <= to 25% + - Diffuse Architecture + - Invasion of Tumor Capsule + - Mitotic Rate > 5/50 HPF + - Necrosis + - Nuclear Grade III or IV + - Sinusoid Invasion + - Venous Invasion + - Unknown + - Not Reported + + weiss_assessment_score: + $ref: + - "_terms.yaml#/weiss_assessment_score/common" + enum: + - "0" + - "1" + - "2" + - "3" + - "4" + - "5" + - "6" + - "7" + - "8" + - "9" + - Unknown + - Not Reported + + who_cns_grade: + $ref: + - "_terms.yaml#/who_cns_grade/common" + enum: + - Grade I + - Grade II + - Grade III + - Grade IV + - Grade Not Assigned + - Unknown + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + who_nte_grade: + $ref: + - "_terms.yaml#/who_nte_grade/common" + enum: + - G1 + - G2 + - G3 + - GX + - Unknown + - Not Reported + enumDef: + G1: + $ref: + - "_terms_enum.yaml#/g1/common" + G2: + $ref: + - "_terms_enum.yaml#/g2/common" + G3: + $ref: + - "_terms_enum.yaml#/g3/common" + GX: + $ref: + - "_terms_enum.yaml#/gx/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + wilms_tumor_histologic_subtype: + $ref: + - "_terms.yaml#/wilms_tumor_histologic_subtype/common" + enum: + - Favorable + - Unfavorable + - Unknown + - Not Reported + enumDef: + Favorable: + $ref: + - "_terms_enum.yaml#/favorable/common" + Unfavorable: + $ref: + - "_terms_enum.yaml#/unfavorable/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + year_of_diagnosis: + $ref: + - "_terms.yaml#/year_of_diagnosis/common" + oneOf: + - type: integer + maximum: 2050 + minimum: 1900 + - type: "null" + + cases: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/experiment_metadata.yaml b/server/data_files/GDC/model-3.3.0/experiment_metadata.yaml new file mode 100644 index 0000000..f53e4cf --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/experiment_metadata.yaml @@ -0,0 +1,86 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "experiment_metadata" +title: Experiment Metadata +type: object +namespace: https://gdc.cancer.gov +category: metadata_file +project: '*' +program: '*' +description: >- + Data file containing the metadata for the experiment performed. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: read_groups + backref: experiment_metadata_files + label: derived_from + target_type: read_group + multiplicity: many_to_one + required: false + - name: files + backref: experiment_metadata_files + label: derived_from + target_type: file + multiplicity: one_to_many + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Raw Sequencing Data + - Sequencing Data + - Sequencing Reads + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Experiment Metadata + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - SRA XML + + read_groups: + $ref: "_definitions.yaml#/to_one" + + files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/experimental_strategy.yaml b/server/data_files/GDC/model-3.3.0/experimental_strategy.yaml new file mode 100644 index 0000000..c658d0e --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/experimental_strategy.yaml @@ -0,0 +1,42 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "experimental_strategy" +title: Experimental Strategy +type: object +namespace: https://gdc.cancer.gov +category: TBD +project: '*' +program: '*' +description: >- + Experimental strategy of a legacy file (deprecated). +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: [] + +required: + - name + +uniqueKeys: + - [id] + - [name] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + + name: + description: >- + name of this record + type: string diff --git a/server/data_files/GDC/model-3.3.0/exposure.yaml b/server/data_files/GDC/model-3.3.0/exposure.yaml new file mode 100644 index 0000000..12ed078 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/exposure.yaml @@ -0,0 +1,972 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "exposure" +title: Exposure +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Clinically relevant patient information not immediately resulting from genetic predispositions. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: cases + backref: exposures + label: describes + target_type: case + multiplicity: many_to_one + required: true + +required: + - submitter_id + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - smokeless_tobacco_quit_age + - asbestos_exposure + - radon_exposure + - respirable_crystalline_silica_exposure + - years_smoked + - coal_dust_exposure + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + age_at_last_exposure: + $ref: + - "_terms.yaml#/age_at_last_exposure/common" + type: integer + maximum: 89 + minimum: 0 + + age_at_onset: + $ref: + - "_terms.yaml#/age_at_onset/common" + type: integer + maximum: 89 + minimum: 0 + + alcohol_days_per_week: + $ref: + - "_terms.yaml#/alcohol_days_per_week/common" + type: number + maximum: 7 + minimum: 0 + + alcohol_drinks_per_day: + $ref: + - "_terms.yaml#/alcohol_drinks_per_day/common" + type: number + minimum: 0 + + alcohol_frequency: + $ref: + - "_terms.yaml#/alcohol_frequency/common" + enum: + - Daily Drinker + - Weekly Drinker + - Not Reported + - Unknown + + alcohol_history: + $ref: + - "_terms.yaml#/alcohol_history/common" + enum: + - "Yes" + - "No" + - "yes" + - "no" + - Unknown + - Not Reported + deprecated_enum: + - "no" + - "yes" + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + "yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "no": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + alcohol_intensity: + $ref: + - "_terms.yaml#/alcohol_intensity/common" + enum: + - Drinker + - Heavy Drinker + - Lifelong Non-Drinker + - Non-Drinker + - Occasional Drinker + - Social Drinker + - Unknown + - Not Reported + enumDef: + Drinker: + $ref: + - "_terms_enum.yaml#/drinker/common" + Heavy Drinker: + $ref: + - "_terms_enum.yaml#/heavy_drinker/common" + Lifelong Non-Drinker: + $ref: + - "_terms_enum.yaml#/lifelong_nondrinker/common" + Non-Drinker: + $ref: + - "_terms_enum.yaml#/nondrinker/common" + Occasional Drinker: + $ref: + - "_terms_enum.yaml#/occasional_drinker/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + alcohol_type: + $ref: + - "_terms.yaml#/alcohol_type/common" + enum: + - Beer + - Liquor + - Wine + - Other + - Unknown + - Not Reported + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + asbestos_exposure: + $ref: + - "_terms.yaml#/asbestos_exposure/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + asbestos_exposure_type: + $ref: + - "_terms.yaml#/asbestos_exposure_type/common" + enum: + - Amosite + - Crocidolite + - Unknown + - Not Reported + + chemical_exposure_type: + $ref: + - "_terms.yaml#/chemical_exposure_type/common" + type: array + items: + enum: + - Agent Orange + - Aluminum + - Arsenic + - Asbestos + - Benzene + - Cadmium + - Chemical Exposure, NOS + - Chromium + - Coal Gas, Coal Tar, Coal Tar Pitch, and Derivatives + - Coke Oven Emission + - Copper + - Diesel Exhaust + - Disinfectant + - Formaldehyde + - Methylene Chloride + - Occupational Soldering/Welding Smoke Exposure + - Oil + - Pesticide + - Petroleum Hydrocarbon Compound + - Resin Fumes + - Sodium Borate + - Solvent + - Tetrachloroethylene + - Toluene + - Unknown + - Not Reported + + cigarettes_per_day: + $ref: + - "_terms.yaml#/cigarettes_per_day/common" + type: number + minimum: 0 + + coal_dust_exposure: + $ref: + - "_terms.yaml#/coal_dust_exposure/common" + enum: + - "Yes" + - "No" + - Unknown + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + environmental_tobacco_smoke_exposure: + $ref: + - "_terms.yaml#/environmental_tobacco_smoke_exposure/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + exposure_duration: + $ref: + - "_terms.yaml#/exposure_duration/common" + enum: + - Six Weeks or More + - Unknown + - Not Reported + enumDef: + Six Weeks or More: + $ref: + - "_terms_enum.yaml#/six_weeks_or_more/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + exposure_duration_hrs_per_day: + $ref: + - "_terms.yaml#/exposure_duration_hrs_per_day/common" + type: number + maximum: 24 + minimum: 0 + + exposure_duration_years: + $ref: + - "_terms.yaml#/exposure_duration_years/common" + type: integer + maximum: 89 + minimum: 0 + + exposure_source: + $ref: + - "_terms.yaml#/exposure_source/common" + enum: + - Home + - Occupational + - Secondary + - Social + - Work + - Unknown + - Not Reported + enumDef: + Home: + $ref: + - "_terms_enum.yaml#/home/common" + Social: + $ref: + - "_terms_enum.yaml#/social/common" + Work: + $ref: + - "_terms_enum.yaml#/work/common" + + exposure_type: + $ref: + - "_terms.yaml#/exposure_type/common" + enum: + - Asbestos + - Chemical + - Coal Dust + - Dust, NOS + - Marijuana + - Radiation + - Radon + - Respirable Crystalline Silica + - Smoke + - Smokeless Tobacco + - Tobacco + - Wood Dust + - Unknown + - Not Reported + enumDef: + Dust, NOS: + $ref: + - "_terms_enum.yaml#/dust/common" + Marijuana: + $ref: + - "_terms_enum.yaml#/marijuana/common" + Tobacco: + $ref: + - "_terms_enum.yaml#/tobacco/common" + + occupation_duration_years: + $ref: + - "_terms.yaml#/occupation_duration_years/common" + type: integer + maximum: 89 + minimum: 0 + + occupation_type: + $ref: + - "_terms.yaml#/occupation_type/common" + type: array + items: + enum: + - Administration Professionals + - Administrative and Specialized Secretaries + - Agricultural, Forestry and Fishery Labourers + - Animal Producers + - Architects, Planners, Surveyors and Designers + - Armed Forces Occupations, Other Ranks + - Artistic, Cultural and Culinary Associate Professionals + - Assemblers + - Authors, Journalists and Linguists + - Blacksmiths, Toolmakers and Related Trades Workers + - Building and Housekeeping Supervisors + - Building Finishers and Related Trades Workers + - Building Frame and Related Trades Workers + - Business Services Agents + - Business Services and Administration Managers + - Car, Van and Motorcycle Drivers + - Cashiers and Ticket Clerks + - Chemical and Photographic Products Plant and Machine Operators + - Child Care Workers and Teachers' Aides + - Client Information Workers + - Commissioned Armed Forces Officers + - Cooks + - Creative and Performing Artists + - Database and Network Professionals + - Domestic, Hotel and Office Cleaners and Helpers + - Electrical Equipment Installers and Repairers + - Electronics and Telecommunications Installers and Repairers + - Electrotechnology Engineers + - Engineering Professionals (excluding Electrotechnology) + - Finance Professionals + - Financial and Mathematical Associate Professionals + - Fishery Workers, Hunters and Trappers + - Food and Related Products Machine Operators + - Food Preparation Assistants + - Food Processing and Related Trades Workers + - Forestry and Related Workers + - Garment and Related Trades Workers + - General Office Clerks + - Government Regulatory Associate Professionals + - Hairdressers, Beauticians and Related Workers + - Handicraft Workers + - Heavy Truck and Bus Drivers + - Hotel and Restaurant Managers + - Information and Communications Technology Operations and User Support Technicians + - Information and Communications Technology Service managers + - Keyboard Operators + - Legal Professionals + - Legal, Social and Religious Associate Professionals + - Legislators and Senior Officials + - Librarians, Archivists and Curators + - Life Science Professionals + - Life Science Technicians and Related Associate Professionals + - Locomotive Engine Drivers and Related Workers + - Machinery Mechanics and Repairers + - Managing Directors and Chief Executives + - Manufacturing Labourers + - Manufacturing, Mining, Construction and Distribution Managers + - Market Gardeners and Crop Growers + - Material Recording and Transport Clerks + - Mathematicians, Actuaries and Statisticians + - Medical and Pharmaceutical Technicians + - Medical Doctors + - Metal Processing and Finishing Plant Operators + - Mining and Construction Labourers + - Mining and Mineral Processing Plant Operators + - Mining, Manufacturing and Construction Supervisors + - Mixed Crop and Animal Producers + - Mobile Plant Operators + - Non-commissioned Armed Forces Officers + - Numerical Clerks + - Nursing and Midwifery Associate Professionals + - Nursing and Midwifery Professionals + - Other Clerical Support Workers + - Other Craft and Related Workers + - Other Elementary Workers + - Other Health Associate Professionals + - Other Health Professionals + - Other Personal Services Workers + - Other Sales Workers + - Other Services Managers + - Other Stationary Plant and Machine Operators + - Other Teaching Professionals + - Painters, Building Structure Cleaners and Related Trades Workers + - Paramedical Practitioners + - Personal Care Workers in Health Services + - Physical and Earth Science Professionals + - Physical and Engineering Science Technicians + - Primary School and Early Childhood Teachers + - Printing Trades Workers + - Process Control Technicians + - Production Managers in Agriculture, Forestry and Fisheries + - Professional Services Managers + - Protective Services Workers + - Refuse Workers + - Retail and Wholesale Trade Managers + - Rubber, Plastic and Paper Products Machine Operators + - Sales and Purchasing Agents and Brokers + - Sales, Marketing and Development Managers + - Sales, Marketing and Public Relations Professionals + - Secondary Education Teachers + - Secretaries (general) + - Sheet and Structural Metal Workers, Moulders and Welders, and Related Workers + - Ship and Aircraft Controllers and Technicians + - Ships' Deck Crews and Related Workers + - Shop Salespersons + - Social and Religious Professionals + - Software and Applications Developers and Analysts + - Sports and Fitness Workers + - Street and Market Salespersons + - Street and Related Service Workers + - Street Vendors (excluding Food) + - Subsistence Crop Farmers + - Subsistence Fishers, Hunters, Trappers and Gatherers + - Subsistence Livestock Farmers + - Subsistence Mixed Crop and Livestock Farmers + - Telecommunications and Broadcasting Technicians + - Tellers, Money Collectors and Related Clerks + - Textile, Fur and Leather Products Machine Operators + - Traditional and Complementary Medicine Associate Professionals + - Traditional and Complementary Medicine Professionals + - Transport and Storage Labourers + - Travel Attendants, Conductors and Guides + - University and Higher Education Teachers + - Vehicle, Window, Laundry and Other Hand Cleaning Workers + - Veterinarians + - Veterinary Technicians and Assistants + - Vocational education teachers + - Waiters and Bartenders + - Wood Processing and Papermaking Plant Operators + - Wood Treaters, Cabinet-makers and Related Trades Workers + - Other + - Unknown + - Not Reported + + pack_years_smoked: + $ref: + - "_terms.yaml#/pack_years_smoked/common" + type: number + minimum: 0 + + parent_with_radiation_exposure: + $ref: + - "_terms.yaml#/parent_with_radiation_exposure/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + radon_exposure: + $ref: + - "_terms.yaml#/radon_exposure/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + respirable_crystalline_silica_exposure: + $ref: + - "_terms.yaml#/respirable_crystalline_silica_exposure/common" + enum: + - "Yes" + - "No" + - Unknown + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + secondhand_smoke_as_child: + $ref: + - "_terms.yaml#/secondhand_smoke_as_child/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + smoking_frequency: + $ref: + - "_terms.yaml#/smoking_frequency/common" + enum: + - Every day + - Some days + - Unknown + - Not Reported + enumDef: + Every day: + $ref: + - "_terms_enum.yaml#/every_day/common" + Some days: + $ref: + - "_terms_enum.yaml#/some_days/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + time_between_waking_and_first_smoke: + $ref: + - "_terms.yaml#/time_between_waking_and_first_smoke/common" + enum: + - Within 5 Minutes + - 6-30 Minutes + - 31-60 Minutes + - After 60 Minutes + - Unknown + - Not Reported + enumDef: + Within 5 Minutes: + $ref: + - "_terms_enum.yaml#/within_5_minutes/common" + 6-30 Minutes: + $ref: + - "_terms_enum.yaml#/630_minutes/common" + 31-60 Minutes: + $ref: + - "_terms_enum.yaml#/3160_minutes/common" + After 60 Minutes: + $ref: + - "_terms_enum.yaml#/after_60_minutes/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + tobacco_smoking_onset_year: + $ref: + - "_terms.yaml#/tobacco_smoking_onset_year/common" + type: integer + maximum: 2050 + minimum: 1900 + + tobacco_smoking_quit_year: + $ref: + - "_terms.yaml#/tobacco_smoking_quit_year/common" + type: integer + maximum: 2050 + minimum: 1900 + + tobacco_smoking_status: + $ref: + - "_terms.yaml#/tobacco_smoking_status/common" + enum: + - "1" + - "2" + - "3" + - "4" + - "5" + - "6" + - "7" + - Current Reformed Smoker, Duration Not Specified + - Current Reformed Smoker for < or = 15 yrs + - Current Reformed Smoker for > 15 yrs + - Current Smoker + - Lifelong Non-Smoker + - Smoker at Diagnosis + - Smoking history not documented + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + - "1" + - "2" + - "3" + - "4" + - "5" + - "6" + - "7" + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + "1": + $ref: + - "_terms_enum.yaml#/1/exposure/tobacco_smoking_status" + "2": + $ref: + - "_terms_enum.yaml#/2/exposure/tobacco_smoking_status" + "3": + $ref: + - "_terms_enum.yaml#/3/exposure/tobacco_smoking_status" + "4": + $ref: + - "_terms_enum.yaml#/4/exposure/tobacco_smoking_status" + "5": + $ref: + - "_terms_enum.yaml#/5/exposure/tobacco_smoking_status" + "6": + $ref: + - "_terms_enum.yaml#/6/exposure/tobacco_smoking_status" + "7": + $ref: + - "_terms_enum.yaml#/7/exposure/tobacco_smoking_status" + + type_of_smoke_exposure: + $ref: + - "_terms.yaml#/type_of_smoke_exposure/common" + enum: + - Accidental building fire smoke + - Accidental fire smoke, grass + - Accidental fire smoke, NOS + - Accidental forest fire smoke + - Accidental vehicle fire smoke + - Aircraft smoke + - Burning tree smoke + - Coal smoke, NOS + - Cooking-related smoke, NOS + - Electrical fire smoke + - Electronic cigarette smoke, NOS + - Environmental tobacco smoke + - Factory smokestack smoke + - Field burning smoke + - Fire smoke, NOS + - Furnace or boiler smoke + - Gas burning smoke, propane + - Grease fire smoke + - Grilling smoke + - Hashish smoke + - Indoor stove or fireplace smoke, coal burning + - Indoor stove or fireplace smoke, NOS + - Indoor stove or fireplace smoke, wood burning + - Machine smoke + - Marijuana smoke + - No Smoke Exposure + - Oil burning smoke, Kerosene + - Oil burning smoke, NOS + - Recreational fire smoke + - Smoke exposure, NOS + - Smokehouse smoke + - Tobacco smoke, cigar + - Tobacco smoke, cigarettes + - Tobacco smoke, NOS + - Tobacco smoke, pipe + - Volcanic smoke + - Waste burning smoke + - Wood burning smoke, factory + - Wood burning smoke, NOS + - Work-related smoke, artificial smoke machines + - Work-related smoke, fire fighting + - Work-related smoke, foundry + - Work-related smoke, generators + - Work-related smoke, military + - Work-related smoke, NOS + - Work-related smoke, paint baking + - Work-related smoke, plastics factory + - Work-related smoke, plumbing + - Work-related smoke, soldering/welding + - Unknown + - Not Reported + enumDef: + Accidental building fire smoke: + $ref: + - "_terms_enum.yaml#/accidental_building_fire_smoke/common" + Accidental fire smoke, grass: + $ref: + - "_terms_enum.yaml#/accidental_fire_smoke_grass/common" + Accidental fire smoke, NOS: + $ref: + - "_terms_enum.yaml#/accidental_fire_smoke_nos/common" + Accidental forest fire smoke: + $ref: + - "_terms_enum.yaml#/accidental_forest_fire_smoke/common" + Accidental vehicle fire smoke: + $ref: + - "_terms_enum.yaml#/accidental_vehicle_fire_smoke/common" + Aircraft smoke: + $ref: + - "_terms_enum.yaml#/aircraft_smoke/common" + Burning tree smoke: + $ref: + - "_terms_enum.yaml#/burning_tree_smoke/common" + Coal smoke, NOS: + $ref: + - "_terms_enum.yaml#/coal_smoke_nos/common" + Cooking-related smoke, NOS: + $ref: + - "_terms_enum.yaml#/cookingrelated_smoke_nos/common" + Electrical fire smoke: + $ref: + - "_terms_enum.yaml#/electrical_fire_smoke/common" + Electronic cigarette smoke, NOS: + $ref: + - "_terms_enum.yaml#/electronic_cigarette_smoke_nos/common" + Environmental tobacco smoke: + $ref: + - "_terms_enum.yaml#/environmental_tobacco_smoke/common" + Factory smokestack smoke: + $ref: + - "_terms_enum.yaml#/factory_smokestack_smoke/common" + Field burning smoke: + $ref: + - "_terms_enum.yaml#/field_burning_smoke/common" + Fire smoke, NOS: + $ref: + - "_terms_enum.yaml#/fire_smoke_nos/common" + Furnace or boiler smoke: + $ref: + - "_terms_enum.yaml#/furnace_or_boiler_smoke/common" + Gas burning smoke, propane: + $ref: + - "_terms_enum.yaml#/gas_burning_smoke_propane/common" + Grease fire smoke: + $ref: + - "_terms_enum.yaml#/grease_fire_smoke/common" + Grilling smoke: + $ref: + - "_terms_enum.yaml#/grilling_smoke/common" + Hashish smoke: + $ref: + - "_terms_enum.yaml#/hashish_smoke/common" + Indoor stove or fireplace smoke, coal burning: + $ref: + - "_terms_enum.yaml#/indoor_stove_or_fireplace_smoke_coal_burning/common" + Indoor stove or fireplace smoke, NOS: + $ref: + - "_terms_enum.yaml#/indoor_stove_or_fireplace_smoke_nos/common" + Indoor stove or fireplace smoke, wood burning: + $ref: + - "_terms_enum.yaml#/indoor_stove_or_fireplace_smoke_wood_burning/common" + Machine smoke: + $ref: + - "_terms_enum.yaml#/machine_smoke/common" + Marijuana smoke: + $ref: + - "_terms_enum.yaml#/marijuana_smoke/common" + No Smoke Exposure: + $ref: + - "_terms_enum.yaml#/no_smoke_exposure/common" + Oil burning smoke, Kerosene: + $ref: + - "_terms_enum.yaml#/oil_burning_smoke_kerosene/common" + Oil burning smoke, NOS: + $ref: + - "_terms_enum.yaml#/oil_burning_smoke_nos/common" + Recreational fire smoke: + $ref: + - "_terms_enum.yaml#/recreational_fire_smoke/common" + Smoke exposure, NOS: + $ref: + - "_terms_enum.yaml#/smoke_exposure_nos/common" + Smokehouse smoke: + $ref: + - "_terms_enum.yaml#/smokehouse_smoke/common" + Tobacco smoke, cigar: + $ref: + - "_terms_enum.yaml#/tobacco_smoke_cigar/common" + Tobacco smoke, cigarettes: + $ref: + - "_terms_enum.yaml#/tobacco_smoke_cigarettes/common" + Tobacco smoke, pipe: + $ref: + - "_terms_enum.yaml#/tobacco_smoke_pipe/common" + Volcanic smoke: + $ref: + - "_terms_enum.yaml#/volcanic_smoke/common" + Waste burning smoke: + $ref: + - "_terms_enum.yaml#/waste_burning_smoke/common" + Wood burning smoke, factory: + $ref: + - "_terms_enum.yaml#/wood_burning_smoke_factory/common" + Wood burning smoke, NOS: + $ref: + - "_terms_enum.yaml#/wood_burning_smoke_nos/common" + Work-related smoke, artificial smoke machines: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_artificial_smoke_machines/common" + Work-related smoke, fire fighting: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_fire_fighting/common" + Work-related smoke, foundry: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_foundry/common" + Work-related smoke, generators: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_generators/common" + Work-related smoke, military: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_military/common" + Work-related smoke, NOS: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_nos/common" + Work-related smoke, paint baking: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_paint_baking/common" + Work-related smoke, plastics factory: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_plastics_factory/common" + Work-related smoke, plumbing: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_plumbing/common" + Work-related smoke, soldering/welding: + $ref: + - "_terms_enum.yaml#/workrelated_smoke_solderingwelding/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + type_of_tobacco_used: + $ref: + - "_terms.yaml#/type_of_tobacco_used/common" + enum: + - Cigar + - Cigarette + - Electronic Cigarette + - Other + - Pipe + - Smokeless Tobacco + enumDef: + Cigar: + $ref: + - "_terms_enum.yaml#/cigar/common" + Cigarette: + $ref: + - "_terms_enum.yaml#/cigarette/common" + Electronic Cigarette: + $ref: + - "_terms_enum.yaml#/electronic_cigarette/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Pipe: + $ref: + - "_terms_enum.yaml#/pipe/common" + Smokeless Tobacco: + $ref: + - "_terms_enum.yaml#/smokeless_tobacco/common" + + use_per_day: + $ref: + - "_terms.yaml#/use_per_day/common" + type: number + minimum: 0 + + years_smoked: + $ref: + - "_terms.yaml#/years_smoked/common" + type: number + maximum: 89 + minimum: 0 + + cases: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/expression_analysis_workflow.yaml b/server/data_files/GDC/model-3.3.0/expression_analysis_workflow.yaml new file mode 100644 index 0000000..6127b14 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/expression_analysis_workflow.yaml @@ -0,0 +1,56 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "expression_analysis_workflow" +title: Expression Analysis Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the expression analysis workflow used to generate additional analysis + on top of the gene expression data. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: gene_expressions + backref: expression_analysis_workflows + label: performed_on + target_type: gene_expression + multiplicity: many_to_one + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - Seurat - 10x Chromium + - Seurat - Smart-Seq2 + + gene_expressions: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/family_history.yaml b/server/data_files/GDC/model-3.3.0/family_history.yaml new file mode 100644 index 0000000..d5f1827 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/family_history.yaml @@ -0,0 +1,834 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "family_history" +title: Family History +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Record of a patient's background regarding cancer events of blood relatives. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: cases + backref: family_histories + label: describes + target_type: case + multiplicity: many_to_one + required: true + +required: + - submitter_id + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + relationship_age_at_diagnosis: + $ref: + - "_terms.yaml#/relationship_age_at_diagnosis/common" + type: number + maximum: 89 + minimum: 0 + + relationship_gender: + $ref: + - "_terms.yaml#/relationship_gender/common" + enum: + - female + - male + - unspecified + - unknown + - not reported + enumDef: + female: + $ref: + - "_terms_enum.yaml#/female/common" + male: + $ref: + - "_terms_enum.yaml#/male/common" + unspecified: + $ref: + - "_terms_enum.yaml#/unspecified/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + relationship_primary_diagnosis: + $ref: + - "_terms.yaml#/relationship_primary_diagnosis/common" + enum: + - Adrenal Gland Cancer + - Basal Cell Cancer + - Bile Duct Cancer + - Bladder Cancer + - Blood Cancer + - Bone Cancer + - Brain Cancer + - Breast Cancer + - Cancer + - Cervical Cancer + - Chondrosarcoma + - CNS Cancer + - Colorectal Cancer + - Esophageal Cancer + - Ewing Sarcoma + - Gallbladder Cancer + - Gastric Cancer + - Glioblastoma + - Gynecologic Cancer + - Head and Neck Cancer + - Hematologic Cancer + - Kaposi Sarcoma + - Kidney Cancer + - Laryngeal Cancer + - Leukemia + - Liver Cancer + - Lung Cancer + - Lymph Node Cancer + - Lymphoma + - Melanoma + - Mesothelioma + - Multiple Myeloma + - Neuroblastoma + - Osteosarcoma + - Ovarian Cancer + - Pancreas Cancer + - Pediatric Liver Cancer + - Prostate Cancer + - Rectal Cancer + - Rhabdomyosarcoma + - Sarcoma + - Skin Cancer + - Spleen Cancer + - Testicular Cancer + - Throat Cancer + - Thyroid Cancer + - Tongue Cancer + - Tonsillar Cancer + - Uterine Cancer + - Wilms Tumor + - Unknown + - Not Reported + enumDef: + Adrenal Gland Cancer: + $ref: + - "_terms_enum.yaml#/adrenal_gland_cancer/common" + Basal Cell Cancer: + $ref: + - "_terms_enum.yaml#/basal_cell_cancer/common" + Bile Duct Cancer: + $ref: + - "_terms_enum.yaml#/bile_duct_cancer/common" + Bladder Cancer: + $ref: + - "_terms_enum.yaml#/bladder_cancer/common" + Blood Cancer: + $ref: + - "_terms_enum.yaml#/blood_cancer/common" + Bone Cancer: + $ref: + - "_terms_enum.yaml#/bone_cancer/common" + Brain Cancer: + $ref: + - "_terms_enum.yaml#/brain_cancer/common" + Breast Cancer: + $ref: + - "_terms_enum.yaml#/breast_cancer/common" + Cancer: + $ref: + - "_terms_enum.yaml#/cancer/common" + Cervical Cancer: + $ref: + - "_terms_enum.yaml#/cervical_cancer/common" + Chondrosarcoma: + $ref: + - "_terms_enum.yaml#/chondrosarcoma/common" + CNS Cancer: + $ref: + - "_terms_enum.yaml#/cns_cancer/common" + Colorectal Cancer: + $ref: + - "_terms_enum.yaml#/colorectal_cancer/common" + Esophageal Cancer: + $ref: + - "_terms_enum.yaml#/esophageal_cancer/common" + Ewing Sarcoma: + $ref: + - "_terms_enum.yaml#/ewing_sarcoma/common" + Gallbladder Cancer: + $ref: + - "_terms_enum.yaml#/gallbladder_cancer/common" + Gastric Cancer: + $ref: + - "_terms_enum.yaml#/gastric_cancer/common" + Glioblastoma: + $ref: + - "_terms_enum.yaml#/glioblastoma/common" + Gynecologic Cancer: + $ref: + - "_terms_enum.yaml#/gynecologic_cancer/common" + Head and Neck Cancer: + $ref: + - "_terms_enum.yaml#/head_and_neck_cancer/common" + Hematologic Cancer: + $ref: + - "_terms_enum.yaml#/hematologic_cancer/common" + Kaposi Sarcoma: + $ref: + - "_terms_enum.yaml#/kaposi_sarcoma/common" + Kidney Cancer: + $ref: + - "_terms_enum.yaml#/kidney_cancer/common" + Laryngeal Cancer: + $ref: + - "_terms_enum.yaml#/laryngeal_cancer/common" + Leukemia: + $ref: + - "_terms_enum.yaml#/leukemia/common" + Liver Cancer: + $ref: + - "_terms_enum.yaml#/liver_cancer/common" + Lung Cancer: + $ref: + - "_terms_enum.yaml#/lung_cancer/common" + Lymph Node Cancer: + $ref: + - "_terms_enum.yaml#/lymph_node_cancer/common" + Lymphoma: + $ref: + - "_terms_enum.yaml#/lymphoma/common" + Melanoma: + $ref: + - "_terms_enum.yaml#/melanoma/common" + Mesothelioma: + $ref: + - "_terms_enum.yaml#/mesothelioma/common" + Multiple Myeloma: + $ref: + - "_terms_enum.yaml#/multiple_myeloma/common" + Neuroblastoma: + $ref: + - "_terms_enum.yaml#/neuroblastoma/common" + Osteosarcoma: + $ref: + - "_terms_enum.yaml#/osteosarcoma/common" + Ovarian Cancer: + $ref: + - "_terms_enum.yaml#/ovarian_cancer/common" + Pancreas Cancer: + $ref: + - "_terms_enum.yaml#/pancreas_cancer/common" + Pediatric Liver Cancer: + $ref: + - "_terms_enum.yaml#/pediatric_liver_cancer/common" + Prostate Cancer: + $ref: + - "_terms_enum.yaml#/prostate_cancer/common" + Rectal Cancer: + $ref: + - "_terms_enum.yaml#/rectal_cancer/common" + Rhabdomyosarcoma: + $ref: + - "_terms_enum.yaml#/rhabdomyosarcoma/common" + Sarcoma: + $ref: + - "_terms_enum.yaml#/sarcoma/common" + Skin Cancer: + $ref: + - "_terms_enum.yaml#/skin_cancer/common" + Spleen Cancer: + $ref: + - "_terms_enum.yaml#/spleen_cancer/common" + Testicular Cancer: + $ref: + - "_terms_enum.yaml#/testicular_cancer/common" + Throat Cancer: + $ref: + - "_terms_enum.yaml#/throat_cancer/common" + Thyroid Cancer: + $ref: + - "_terms_enum.yaml#/thyroid_cancer/common" + Tongue Cancer: + $ref: + - "_terms_enum.yaml#/tongue_cancer/common" + Tonsillar Cancer: + $ref: + - "_terms_enum.yaml#/tonsillar_cancer/common" + Uterine Cancer: + $ref: + - "_terms_enum.yaml#/uterine_cancer/common" + Wilms Tumor: + $ref: + - "_terms_enum.yaml#/wilms_tumor/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + relationship_type: + $ref: + - "_terms.yaml#/relationship_type/common" + enum: + - Adopted Brother + - Adopted Daughter + - Adopted Sister + - Adopted Son + - Adoptive Father + - Adoptive Mother + - Aunt + - Brother + - Brother-in-law + - Child + - Cousin + - Daughter + - Daughter-in-law + - Domestic Partner + - Father + - Father-in-law + - Female Cousin + - Female Sibling of Adopted Child + - First Cousin + - First Cousin Once Removed + - First Degree Relative, NOS + - Foster Brother + - Foster Daughter + - Foster Father + - Foster Mother + - Foster Sister + - Foster Son + - Fraternal Twin Brother + - Fraternal Twin Sibling + - Fraternal Twin Sister + - Full Brother + - Full Sister + - Grand Nephew + - Grand Niece + - Grandchild + - Granddaughter + - Grandfather + - Grandmother + - Grandparent + - Grandson + - Great Grandchild + - Half Brother + - Half Sibling + - Half Sister + - Husband + - Identical Twin Brother + - Identical Twin Sibling + - Identical Twin Sister + - Legal Guardian + - Male Cousin + - Male Sibling of Adopted Child + - Maternal Aunt + - Maternal First Cousin + - Maternal First Cousin Once Removed + - Maternal Grandfather + - Maternal Grandmother + - Maternal Grandparent + - Maternal Great Aunt + - Maternal Great Grandparent + - Maternal Great Uncle + - Maternal Half Brother + - Maternal Half Sibling + - Maternal Half Sister + - Maternal Uncle + - Mother + - Mother-in-law + - Natural Brother + - Natural Child + - Natural Daughter + - Natural Father + - Natural Grandchild + - Natural Grandfather + - Natural Grandmother + - Natural Grandparent + - Natural Mother + - Natural Parent + - Natural Sibling + - Natural Sister + - Natural Son + - Nephew + - Niece + - Niece Second Degree Relative + - Parent + - Paternal Aunt + - Paternal First Cousin + - Paternal First Cousin Once Removed + - Paternal Grandfather + - Paternal Grandmother + - Paternal Grandparent + - Paternal Great Aunt + - Paternal Great Grandparent + - Paternal Great Uncle + - Paternal Half Brother + - Paternal Half Sibling + - Paternal Half Sister + - Paternal Uncle + - Sibling + - Sister + - Sister-in-law + - Son + - Son-in-law + - Spouse + - Step Child + - Step Sibling + - Stepbrother + - Stepdaughter + - Stepfather + - Stepmother + - Stepsister + - Stepson + - Twin Sibling + - Uncle + - Unrelated + - Ward + - Wife + - Other + - Unknown + - Not Reported + enumDef: + Adopted Brother: + $ref: + - "_terms_enum.yaml#/adopted_brother/common" + Adopted Daughter: + $ref: + - "_terms_enum.yaml#/adopted_daughter/common" + Adopted Sister: + $ref: + - "_terms_enum.yaml#/adopted_sister/common" + Adopted Son: + $ref: + - "_terms_enum.yaml#/adopted_son/common" + Adoptive Father: + $ref: + - "_terms_enum.yaml#/adoptive_father/common" + Adoptive Mother: + $ref: + - "_terms_enum.yaml#/adoptive_mother/common" + Aunt: + $ref: + - "_terms_enum.yaml#/aunt/common" + Brother: + $ref: + - "_terms_enum.yaml#/brother/common" + Brother-in-law: + $ref: + - "_terms_enum.yaml#/brotherinlaw/common" + Child: + $ref: + - "_terms_enum.yaml#/child/common" + Cousin: + $ref: + - "_terms_enum.yaml#/cousin/common" + Daughter: + $ref: + - "_terms_enum.yaml#/daughter/common" + Daughter-in-law: + $ref: + - "_terms_enum.yaml#/daughterinlaw/common" + Domestic Partner: + $ref: + - "_terms_enum.yaml#/domestic_partner/common" + Father: + $ref: + - "_terms_enum.yaml#/father/common" + Father-in-law: + $ref: + - "_terms_enum.yaml#/fatherinlaw/common" + Female Cousin: + $ref: + - "_terms_enum.yaml#/female_cousin/common" + Female Sibling of Adopted Child: + $ref: + - "_terms_enum.yaml#/female_sibling_of_adopted_child/common" + First Cousin: + $ref: + - "_terms_enum.yaml#/first_cousin/common" + First Cousin Once Removed: + $ref: + - "_terms_enum.yaml#/first_cousin_once_removed/common" + Foster Brother: + $ref: + - "_terms_enum.yaml#/foster_brother/common" + Foster Daughter: + $ref: + - "_terms_enum.yaml#/foster_daughter/common" + Foster Father: + $ref: + - "_terms_enum.yaml#/foster_father/common" + Foster Mother: + $ref: + - "_terms_enum.yaml#/foster_mother/common" + Foster Sister: + $ref: + - "_terms_enum.yaml#/foster_sister/common" + Foster Son: + $ref: + - "_terms_enum.yaml#/foster_son/common" + Fraternal Twin Brother: + $ref: + - "_terms_enum.yaml#/fraternal_twin_brother/common" + Fraternal Twin Sibling: + $ref: + - "_terms_enum.yaml#/fraternal_twin_sibling/common" + Fraternal Twin Sister: + $ref: + - "_terms_enum.yaml#/fraternal_twin_sister/common" + Full Brother: + $ref: + - "_terms_enum.yaml#/full_brother/common" + Full Sister: + $ref: + - "_terms_enum.yaml#/full_sister/common" + Grand Nephew: + $ref: + - "_terms_enum.yaml#/grand_nephew/common" + Grand Niece: + $ref: + - "_terms_enum.yaml#/grand_niece/common" + Grandchild: + $ref: + - "_terms_enum.yaml#/grandchild/common" + Granddaughter: + $ref: + - "_terms_enum.yaml#/granddaughter/common" + Grandfather: + $ref: + - "_terms_enum.yaml#/grandfather/common" + Grandmother: + $ref: + - "_terms_enum.yaml#/grandmother/common" + Grandparent: + $ref: + - "_terms_enum.yaml#/grandparent/common" + Grandson: + $ref: + - "_terms_enum.yaml#/grandson/common" + Great Grandchild: + $ref: + - "_terms_enum.yaml#/great_grandchild/common" + Half Brother: + $ref: + - "_terms_enum.yaml#/half_brother/common" + Half Sibling: + $ref: + - "_terms_enum.yaml#/half_sibling/common" + Half Sister: + $ref: + - "_terms_enum.yaml#/half_sister/common" + Husband: + $ref: + - "_terms_enum.yaml#/husband/common" + Identical Twin Brother: + $ref: + - "_terms_enum.yaml#/identical_twin_brother/common" + Identical Twin Sibling: + $ref: + - "_terms_enum.yaml#/identical_twin_sibling/common" + Identical Twin Sister: + $ref: + - "_terms_enum.yaml#/identical_twin_sister/common" + Legal Guardian: + $ref: + - "_terms_enum.yaml#/legal_guardian/common" + Male Cousin: + $ref: + - "_terms_enum.yaml#/male_cousin/common" + Male Sibling of Adopted Child: + $ref: + - "_terms_enum.yaml#/male_sibling_of_adopted_child/common" + Maternal Aunt: + $ref: + - "_terms_enum.yaml#/maternal_aunt/common" + Maternal First Cousin: + $ref: + - "_terms_enum.yaml#/maternal_first_cousin/common" + Maternal First Cousin Once Removed: + $ref: + - "_terms_enum.yaml#/maternal_first_cousin_once_removed/common" + Maternal Grandfather: + $ref: + - "_terms_enum.yaml#/maternal_grandfather/common" + Maternal Grandmother: + $ref: + - "_terms_enum.yaml#/maternal_grandmother/common" + Maternal Grandparent: + $ref: + - "_terms_enum.yaml#/maternal_grandparent/common" + Maternal Great Aunt: + $ref: + - "_terms_enum.yaml#/maternal_great_aunt/common" + Maternal Great Grandparent: + $ref: + - "_terms_enum.yaml#/maternal_great_grandparent/common" + Maternal Great Uncle: + $ref: + - "_terms_enum.yaml#/maternal_great_uncle/common" + Maternal Half Brother: + $ref: + - "_terms_enum.yaml#/maternal_half_brother/common" + Maternal Half Sibling: + $ref: + - "_terms_enum.yaml#/maternal_half_sibling/common" + Maternal Half Sister: + $ref: + - "_terms_enum.yaml#/maternal_half_sister/common" + Maternal Uncle: + $ref: + - "_terms_enum.yaml#/maternal_uncle/common" + Mother: + $ref: + - "_terms_enum.yaml#/mother/common" + Mother-in-law: + $ref: + - "_terms_enum.yaml#/motherinlaw/common" + Natural Brother: + $ref: + - "_terms_enum.yaml#/natural_brother/common" + Natural Child: + $ref: + - "_terms_enum.yaml#/natural_child/common" + Natural Daughter: + $ref: + - "_terms_enum.yaml#/natural_daughter/common" + Natural Father: + $ref: + - "_terms_enum.yaml#/natural_father/common" + Natural Grandchild: + $ref: + - "_terms_enum.yaml#/natural_grandchild/common" + Natural Grandfather: + $ref: + - "_terms_enum.yaml#/natural_grandfather/common" + Natural Grandmother: + $ref: + - "_terms_enum.yaml#/natural_grandmother/common" + Natural Grandparent: + $ref: + - "_terms_enum.yaml#/natural_grandparent/common" + Natural Mother: + $ref: + - "_terms_enum.yaml#/natural_mother/common" + Natural Parent: + $ref: + - "_terms_enum.yaml#/natural_parent/common" + Natural Sibling: + $ref: + - "_terms_enum.yaml#/natural_sibling/common" + Natural Sister: + $ref: + - "_terms_enum.yaml#/natural_sister/common" + Natural Son: + $ref: + - "_terms_enum.yaml#/natural_son/common" + Nephew: + $ref: + - "_terms_enum.yaml#/nephew/common" + Niece: + $ref: + - "_terms_enum.yaml#/niece/common" + Niece Second Degree Relative: + $ref: + - "_terms_enum.yaml#/niece_second_degree_relative/common" + Parent: + $ref: + - "_terms_enum.yaml#/parent/common" + Paternal Aunt: + $ref: + - "_terms_enum.yaml#/paternal_aunt/common" + Paternal First Cousin: + $ref: + - "_terms_enum.yaml#/paternal_first_cousin/common" + Paternal First Cousin Once Removed: + $ref: + - "_terms_enum.yaml#/paternal_first_cousin_once_removed/common" + Paternal Grandfather: + $ref: + - "_terms_enum.yaml#/paternal_grandfather/common" + Paternal Grandmother: + $ref: + - "_terms_enum.yaml#/paternal_grandmother/common" + Paternal Grandparent: + $ref: + - "_terms_enum.yaml#/paternal_grandparent/common" + Paternal Great Aunt: + $ref: + - "_terms_enum.yaml#/paternal_great_aunt/common" + Paternal Great Grandparent: + $ref: + - "_terms_enum.yaml#/paternal_great_grandparent/common" + Paternal Great Uncle: + $ref: + - "_terms_enum.yaml#/paternal_great_uncle/common" + Paternal Half Brother: + $ref: + - "_terms_enum.yaml#/paternal_half_brother/common" + Paternal Half Sibling: + $ref: + - "_terms_enum.yaml#/paternal_half_sibling/common" + Paternal Half Sister: + $ref: + - "_terms_enum.yaml#/paternal_half_sister/common" + Paternal Uncle: + $ref: + - "_terms_enum.yaml#/paternal_uncle/common" + Sibling: + $ref: + - "_terms_enum.yaml#/sibling/common" + Sister: + $ref: + - "_terms_enum.yaml#/sister/common" + Sister-in-law: + $ref: + - "_terms_enum.yaml#/sisterinlaw/common" + Son: + $ref: + - "_terms_enum.yaml#/son/common" + Son-in-law: + $ref: + - "_terms_enum.yaml#/soninlaw/common" + Spouse: + $ref: + - "_terms_enum.yaml#/spouse/common" + Step Child: + $ref: + - "_terms_enum.yaml#/step_child/common" + Step Sibling: + $ref: + - "_terms_enum.yaml#/step_sibling/common" + Stepbrother: + $ref: + - "_terms_enum.yaml#/stepbrother/common" + Stepdaughter: + $ref: + - "_terms_enum.yaml#/stepdaughter/common" + Stepfather: + $ref: + - "_terms_enum.yaml#/stepfather/common" + Stepmother: + $ref: + - "_terms_enum.yaml#/stepmother/common" + Stepsister: + $ref: + - "_terms_enum.yaml#/stepsister/common" + Stepson: + $ref: + - "_terms_enum.yaml#/stepson/common" + Twin Sibling: + $ref: + - "_terms_enum.yaml#/twin_sibling/common" + Uncle: + $ref: + - "_terms_enum.yaml#/uncle/common" + Unrelated: + $ref: + - "_terms_enum.yaml#/unrelated/common" + Ward: + $ref: + - "_terms_enum.yaml#/ward/common" + Wife: + $ref: + - "_terms_enum.yaml#/wife/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + relative_deceased: + $ref: + - "_terms.yaml#/relative_deceased/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + relative_smoker: + $ref: + - "_terms.yaml#/relative_smoker/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + relative_with_cancer_history: + $ref: + - "_terms.yaml#/relative_with_cancer_history/common" + enum: + - "yes" + - "no" + - unknown + - not reported + enumDef: + "yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "no": + $ref: + - "_terms_enum.yaml#/no/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + relatives_with_cancer_history_count: + $ref: + - "_terms.yaml#/relatives_with_cancer_history_count/common" + type: integer + minimum: 0 + + cases: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/file.yaml b/server/data_files/GDC/model-3.3.0/file.yaml new file mode 100644 index 0000000..a861fc8 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/file.yaml @@ -0,0 +1,190 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "file" +title: File +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + A set of related records (either written or electronic) kept together. (NCIt C42883) +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: false + required: false + subgroup: + - name: aliquots + backref: files + label: data_from + target_type: aliquot + multiplicity: many_to_many + required: false + - name: analytes + backref: files + label: data_from + target_type: analyte + multiplicity: many_to_many + required: false + - name: cases + backref: files + label: data_from + target_type: case + multiplicity: many_to_many + required: false + - name: derived_files + backref: source_files + label: data_from + target_type: file + multiplicity: many_to_many + required: false + - name: portions + backref: files + label: data_from + target_type: portion + multiplicity: many_to_many + required: false + - name: samples + backref: files + label: data_from + target_type: sample + multiplicity: many_to_many + required: false + - name: slides + backref: files + label: data_from + target_type: slide + multiplicity: many_to_many + required: false + - name: related_files + backref: parent_files + label: related_to + target_type: file + multiplicity: many_to_many + required: false + - name: tags + backref: files + label: memeber_of + target_type: tag + multiplicity: many_to_many + required: false + - name: archives + backref: files + label: member_of + target_type: archive + multiplicity: many_to_one + required: false + - name: data_subtypes + backref: files + label: member_of + target_type: data_subtype + multiplicity: many_to_one + required: false + - name: data_formats + backref: files + label: member_of + target_type: data_format + multiplicity: many_to_one + required: false + - name: experimental_strategies + backref: files + label: member_of + target_type: experimental_strategy + multiplicity: many_to_one + required: false + - name: centers + backref: files + label: submitted_by + target_type: center + multiplicity: many_to_one + required: false + - name: platforms + backref: files + label: generated_from + target_type: platform + multiplicity: many_to_one + required: false + - name: described_cases + backref: describing_files + label: describes + target_type: case + multiplicity: many_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - state + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + aliquots: + $ref: "_definitions.yaml#/to_many" + + analytes: + $ref: "_definitions.yaml#/to_many" + + cases: + $ref: "_definitions.yaml#/to_many" + + derived_files: + $ref: "_definitions.yaml#/to_many" + + portions: + $ref: "_definitions.yaml#/to_many" + + samples: + $ref: "_definitions.yaml#/to_many" + + slides: + $ref: "_definitions.yaml#/to_many" + + related_files: + $ref: "_definitions.yaml#/to_many" + + tags: + $ref: "_definitions.yaml#/to_many" + + archives: + $ref: "_definitions.yaml#/to_one" + + data_subtypes: + $ref: "_definitions.yaml#/to_one" + + data_formats: + $ref: "_definitions.yaml#/to_one" + + experimental_strategies: + $ref: "_definitions.yaml#/to_one" + + centers: + $ref: "_definitions.yaml#/to_one" + + platforms: + $ref: "_definitions.yaml#/to_one" + + described_cases: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/filtered_copy_number_segment.yaml b/server/data_files/GDC/model-3.3.0/filtered_copy_number_segment.yaml new file mode 100644 index 0000000..9340f76 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/filtered_copy_number_segment.yaml @@ -0,0 +1,88 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "filtered_copy_number_segment" +title: Filtered Copy Number Segment +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing copy number information that has been lifted over and filtered. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: copy_number_liftover_workflows + backref: filtered_copy_number_segments + label: data_from + target_type: copy_number_liftover_workflow + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Copy Number Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TXT + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Copy Number Segment + - Masked Copy Number Segment + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Genotyping Array + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Affymetrix SNP 6.0 + - Illumina + - Other + + copy_number_liftover_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/follow_up.yaml b/server/data_files/GDC/model-3.3.0/follow_up.yaml new file mode 100644 index 0000000..86c8d58 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/follow_up.yaml @@ -0,0 +1,3170 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "follow_up" +title: Follow-Up +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + A visit by a patient or study participant to a medical professional. A clinical + encounter that encompasses planned and unplanned trial interventions, procedures + and assessments that may be performed on a subject. A visit has a start and an end, + each described with a rule. The process by which information about the health status + of an individual is obtained before and after a study has officially closed; an + activity that continues something that has already begun or that repeats something + that has already been done. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: cases + backref: follow_ups + label: describes + target_type: case + multiplicity: many_to_one + required: true + - name: diagnoses + backref: follow_ups + label: describes + target_type: diagnosis + multiplicity: many_to_one + required: false + +required: + - submitter_id + - days_to_follow_up + - cases + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - aids_risk_factors + - bmi + - body_surface_area + - cd4_count + - cdc_hiv_risk_factors + - comorbidity + - comorbidity_method_of_diagnosis + - comorbidities + - days_to_comorbidity + - days_to_risk_factor + - diabetes_treatment_type + - dlco_ref_predictive_percent + - eye_color + - fev1_fvc_post_bronch_percent + - fev1_fvc_pre_bronch_percent + - fev1_ref_post_bronch_percent + - fev1_ref_pre_bronch_percent + - haart_treatment_indicator + - height + - hepatitis_sustained_virological_response + - hiv_viral_load + - hormonal_contraceptive_type + - hormonal_contraceptive_use + - hormone_replacement_therapy_type + - hpv_positive_type + - hysterectomy_margins_involved + - hysterectomy_type + - immunosuppressive_treatment_type + - menopause_status + - nadir_cd4_count + - pancreatitis_onset_year + - pregnancy_count + - pregnancy_outcome + - reflux_treatment_type + - risk_factor + - risk_factor_method_of_diagnosis + - risk_factor_treatment + - risk_factors + - undescended_testis_corrected + - undescended_testis_corrected_age + - undescended_testis_corrected_laterality + - undescended_testis_corrected_method + - undescended_testis_history + - undescended_testis_history_laterality + - viral_hepatitis_serologies + - weight + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + adverse_event: + $ref: + - "_terms.yaml#/adverse_event/common" + enum: + - Abdominal Distension + - Abdominal Infection + - Abdominal Pain + - Abdominal Soft Tissue Necrosis + - Abducens Nerve Disorder + - Accessory Nerve Disorder + - Acidosis + - Acoustic Nerve Disorder NOS + - Activated Partial Thromboplastin Time Prolonged + - Acute Coronary Syndrome + - Acute Kidney Injury + - Adrenal Insufficiency + - Adult Respiratory Distress Syndrome + - Agitation + - Akathisia + - Alanine Aminotransferase Increased + - Alcohol Intolerance + - Alkaline Phosphatase Increased + - Alkalosis + - Allergic Reaction + - Allergic Rhinitis + - Alopecia + - Amnesia + - Anal Fistula + - Anal Hemorrhage + - Anal Mucositis + - Anal Necrosis + - Anal Pain + - Anal Stenosis + - Anal Ulcer + - Anaphylaxis + - Anemia + - Ankle Fracture + - Anorectal Infection + - Anorexia + - Anorgasmia + - Anxiety + - Aortic Injury + - Aortic Valve Disease + - Aphonia + - Apnea + - Appendicitis + - Appendicitis Perforated + - Arachnoiditis + - Arterial Injury + - Arteritis Infective + - Arthralgia + - Arthritis + - Ascites + - Aspartate Aminotransferase Increased + - Aspiration + - Asystole + - Ataxia + - Atelectasis + - Atrial Fibrillation + - Atrial Flutter + - Atrioventricular Block Complete + - Atrioventricular Block First Degree + - Autoimmune Disorder + - Avascular Necrosis + - Azoospermia + - Back Pain + - Bile Duct Stenosis + - Biliary Anastomotic Leak + - Biliary Fistula + - Biliary Tract Infection + - Bladder Anastomotic Leak + - Bladder Infection + - Bladder Perforation + - Bladder Spasm + - Bloating + - Blood and Lymphatic System Disorders - Other + - Blood Antidiuretic Hormone Abnormal + - Blood Bilirubin Increased + - Blood Corticotrophin Decreased + - Blood Gonadotrophin Abnormal + - Blood Prolactin Abnormal + - Blurred Vision + - Body Odor + - Bone Infection + - Bone Marrow Hypocellular + - Bone Pain + - Brachial Plexopathy + - Breast Atrophy + - Breast Infection + - Breast Pain + - Bronchial Fistula + - Bronchial Infection + - Bronchial Obstruction + - Bronchial Stricture + - Bronchopleural Fistula + - Bronchopulmonary Hemorrhage + - Bronchospasm + - Bruising + - Bullous Dermatitis + - Burn + - Buttock Pain + - Capillary Leak Syndrome + - Carbon Monoxide Diffusing Capacity Decreased + - Cardiac Arrest + - Cardiac Disorders - Other + - Cardiac Ischemia + - Cardiac Troponin I Increased + - Cardiac Troponin T Increased + - Cataract + - Catheter Related Infection + - CD4 Lymphocytes Decreased + - Cecal Hemorrhage + - Cecal Infection + - Central Nervous System Necrosis + - Cerebrospinal Fluid Leakage + - Cervicitis Infection + - Cheilitis + - Chest Pain - Cardiac + - Chest Wall Pain + - Chills + - Cholecystitis + - Cholesterol High + - Chronic Kidney Disease + - Chylothorax + - Cognitive Disturbance + - Colitis + - Colonic Fistula + - Colonic Hemorrhage + - Colonic Obstruction + - Colonic Perforation + - Colonic Stenosis + - Colonic Ulcer + - Concentration Impairment + - Conduction Disorder + - Confusion + - Congenital, Familial and Genetic Disorders - Other + - Conjunctivitis + - Conjunctivitis Infective + - Constipation + - Constrictive Pericarditis + - Corneal Infection + - Corneal Ulcer + - Cough + - CPK Increased + - Cranial Nerve Infection + - Creatinine Increased + - Cushingoid + - Cystitis Noninfective + - Cytokine Release Syndrome + - Death Neonatal + - Death NOS + - Dehydration + - Delayed Orgasm + - Delayed Puberty + - Delirium + - Delusions + - Dental Caries + - Depressed Level of Consciousness + - Depression + - Dermatitis Radiation + - Device Related Infection + - Diarrhea + - Disseminated Intravascular Coagulation + - Dizziness + - Dry Eye + - Dry Mouth + - Dry Skin + - Duodenal Fistula + - Duodenal Hemorrhage + - Duodenal Infection + - Duodenal Obstruction + - Duodenal Perforation + - Duodenal Stenosis + - Duodenal Ulcer + - Dysarthria + - Dysesthesia + - Dysgeusia + - Dysmenorrhea + - Dyspareunia + - Dyspepsia + - Dysphagia + - Dysphasia + - Dyspnea + - Ear and Labyrinth Disorders - Other + - Ear Pain + - Edema Cerebral + - Edema Face + - Edema Limbs + - Edema Trunk + - Ejaculation Disorder + - Ejection Fraction Decreased + - Electrocardiogram QT Corrected Interval Prolonged + - Encephalitis Infection + - Encephalomyelitis Infection + - Encephalopathy + - Endocarditis Infective + - Endocrine Disorders - Other + - Endophthalmitis + - Enterocolitis + - Enterocolitis Infectious + - Enterovesical Fistula + - Epistaxis + - Erectile Dysfunction + - Erythema Multiforme + - Erythroderma + - Esophageal Anastomotic Leak + - Esophageal Fistula + - Esophageal Hemorrhage + - Esophageal Infection + - Esophageal Necrosis + - Esophageal Obstruction + - Esophageal Pain + - Esophageal Perforation + - Esophageal Stenosis + - Esophageal Ulcer + - Esophageal Varices Hemorrhage + - Esophagitis + - Euphoria + - Exostosis + - External Ear Inflammation + - External Ear Pain + - Extraocular Muscle Paresis + - Extrapyramidal Disorder + - Eye Disorders - Other + - Eye Infection + - Eye Pain + - Eyelid Function Disorder + - Facial Muscle Weakness + - Facial Nerve Disorder + - Facial Pain + - Fall + - Fallopian Tube Anastomotic Leak + - Fallopian Tube Obstruction + - Fallopian Tube Perforation + - Fallopian Tube Stenosis + - Fat Atrophy + - Fatigue + - Febrile Neutropenia + - Fecal Incontinence + - Female Genital Tract Fistula + - Feminization Acquired + - Fetal Death + - Fetal Growth Retardation + - Fever + - Fibrinogen Decreased + - Fibrosis Deep Connective Tissue + - Flank Pain + - Flashing Lights + - Flatulence + - Floaters + - Flu Like Symptoms + - Flushing + - Forced Expiratory Volume Decreased + - Fracture + - Gait Disturbance + - Gallbladder Fistula + - Gallbladder Infection + - Gallbladder Necrosis + - Gallbladder Obstruction + - Gallbladder Pain + - Gallbladder Perforation + - Gastric Anastomotic Leak + - Gastric Fistula + - Gastric Hemorrhage + - Gastric Necrosis + - Gastric Perforation + - Gastric Stenosis + - Gastric Ulcer + - Gastritis + - Gastroesophageal Reflux Disease + - Gastrointestinal Anastomotic Leak + - Gastrointestinal Disorders - Other + - Gastrointestinal Fistula + - Gastrointestinal Pain + - Gastrointestinal Stoma Necrosis + - Gastroparesis + - General Disorders and Administration Site Conditions - Other + - Generalized Muscle Weakness + - Genital Edema + - GGT Increased + - Gingival Pain + - Glaucoma + - Glomerular Filtration Rate Decreased + - Glossopharyngeal Nerve Disorder + - Glucose Intolerance + - Growth Accelerated + - Growth Hormone Abnormal + - Growth Suppression + - Gum Infection + - Gynecomastia + - Hallucinations + - Haptoglobin Decreased + - Head Soft Tissue Necrosis + - Headache + - Hearing Impaired + - Heart Failure + - Hematoma + - Hematosalpinx + - Hematuria + - Hemoglobin Increased + - Hemoglobinuria + - Hemolysis + - Hemolytic Uremic Syndrome + - Hemorrhoidal Hemorrhage + - Hemorrhoids + - Hepatic Failure + - Hepatic Hemorrhage + - Hepatic Infection + - Hepatic Necrosis + - Hepatic Pain + - Hepatitis Viral + - Hepatobiliary Disorders - Other + - Hiccups + - Hip Fracture + - Hirsutism + - Hoarseness + - Hot Flashes + - Hydrocephalus + - Hypercalcemia + - Hyperglycemia + - Hyperhidrosis + - Hyperkalemia + - Hypermagnesemia + - Hypernatremia + - Hyperparathyroidism + - Hypersomnia + - Hypertension + - Hyperthyroidism + - Hypertrichosis + - Hypertriglyceridemia + - Hyperuricemia + - Hypoalbuminemia + - Hypocalcemia + - Hypoglossal Nerve Disorder + - Hypoglycemia + - Hypohidrosis + - Hypokalemia + - Hypomagnesemia + - Hyponatremia + - Hypoparathyroidism + - Hypophosphatemia + - Hypotension + - Hypothermia + - Hypothyroidism + - Hypoxia + - Ileal Fistula + - Ileal Hemorrhage + - Ileal Obstruction + - Ileal Perforation + - Ileal Stenosis + - Ileal Ulcer + - Ileus + - Immune System Disorders - Other + - Infections and Infestations - Other + - Infective Myositis + - Infusion Related Reaction + - Infusion Site Extravasation + - Injection Site Reaction + - Injury to Carotid Artery + - Injury to Inferior Vena Cava + - Injury to Jugular Vein + - Injury to Superior Vena Cava + - Injury, Poisoning and Procedural Complications - Other + - INR Increased + - Insomnia + - Intestinal Stoma Leak + - Intestinal Stoma Obstruction + - Intestinal Stoma Site Bleeding + - Intra-Abdominal Hemorrhage + - Intracranial Hemorrhage + - Intraoperative Arterial Injury + - Intraoperative Breast Injury + - Intraoperative Cardiac Injury + - Intraoperative Ear Injury + - Intraoperative Endocrine Injury + - Intraoperative Gastrointestinal Injury + - Intraoperative Head and Neck Injury + - Intraoperative Hemorrhage + - Intraoperative Hepatobiliary Injury + - Intraoperative Musculoskeletal Injury + - Intraoperative Neurological Injury + - Intraoperative Ocular Injury + - Intraoperative Renal Injury + - Intraoperative Reproductive Tract Injury + - Intraoperative Respiratory Injury + - Intraoperative Skin Injury + - Intraoperative Splenic Injury + - Intraoperative Urinary Injury + - Intraoperative Venous Injury + - Investigations - Other + - Iron Overload + - Irregular Menstruation + - Irritability + - Ischemia Cerebrovascular + - IVth Nerve Disorder + - Jejunal Fistula + - Jejunal Hemorrhage + - Jejunal Obstruction + - Jejunal Perforation + - Jejunal Stenosis + - Jejunal Ulcer + - Joint Effusion + - Joint Infection + - Joint Pain + - Joint Range of Motion Decreased + - Joint Range of Motion Decreased Cervical Spine + - Joint Range of Motion Decreased Lumbar Spine + - Keratitis + - Kidney Anastomotic Leak + - Kidney Infection + - Kyphosis + - Lactation Disorder + - Large Intestinal Anastomotic Leak + - Laryngeal Edema + - Laryngeal Fistula + - Laryngeal Hemorrhage + - Laryngeal Inflammation + - Laryngeal Mucositis + - Laryngeal Obstruction + - Laryngeal Stenosis + - Laryngitis + - Laryngopharyngeal Dysesthesia + - Laryngospasm + - Left Ventricular Systolic Dysfunction + - Lethargy + - Leukemia Secondary to Oncology Chemotherapy + - Leukocytosis + - Leukoencephalopathy + - Libido Decreased + - Libido Increased + - Lip Infection + - Lip Pain + - Lipase Increased + - Lipohypertrophy + - Localized Edema + - Lordosis + - Lower Gastrointestinal Hemorrhage + - Lung Infection + - Lymph Gland Infection + - Lymph Leakage + - Lymph Node Pain + - Lymphedema + - Lymphocele + - Lymphocyte Count Decreased + - Lymphocyte Count Increased + - Malabsorption + - Malaise + - Mania + - Mediastinal Hemorrhage + - Mediastinal Infection + - Memory Impairment + - Meningismus + - Meningitis + - Menopause + - Menorrhagia + - Metabolism and Nutrition Disorders - Other + - Middle Ear Inflammation + - Mitral Valve Disease + - Mobitz (Type) II Atrioventricular Block + - Mobitz Type I + - Movements Involuntary + - Mucosal Infection + - Mucositis Oral + - Multi-Organ Failure + - Muscle Weakness Left-Sided + - Muscle Weakness Lower Limb + - Muscle Weakness Right-Sided + - Muscle Weakness Trunk + - Muscle Weakness Upper Limb + - Musculoskeletal and Connective Tissue Disorders - Other + - Musculoskeletal Deformity + - Myalgia + - Myelitis + - Myelodysplastic Syndrome + - Myocardial Infarction + - Myocarditis + - Myositis + - Nail Discoloration + - Nail Infection + - Nail Loss + - Nail Ridging + - Nasal Congestion + - Nausea + - Neck Edema + - Neck Pain + - Neck Soft Tissue Necrosis + - Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other + - Nervous System Disorders - Other + - Neuralgia + - Neutrophil Count Decreased + - Night Blindness + - Nipple Deformity + - Non-Cardiac Chest Pain + - Nystagmus + - Obesity + - Obstruction Gastric + - Oculomotor Nerve Disorder + - Olfactory Nerve Disorder + - Oligospermia + - Optic Nerve Disorder + - Oral Cavity Fistula + - Oral Dysesthesia + - Oral Hemorrhage + - Oral Pain + - Osteonecrosis of Jaw + - Osteoporosis + - Otitis Externa + - Otitis Media + - Ovarian Hemorrhage + - Ovarian Infection + - Ovarian Rupture + - Ovulation Pain + - Pain + - Pain in Extremity + - Pain of Skin + - Palmar-Plantar Erythrodysesthesia Syndrome + - Palpitations + - Pancreas Infection + - Pancreatic Anastomotic Leak + - Pancreatic Duct Stenosis + - Pancreatic Enzymes Decreased + - Pancreatic Fistula + - Pancreatic Hemorrhage + - Pancreatic Necrosis + - Pancreatitis + - Papilledema + - Papulopustular Rash + - Paresthesia + - Paronychia + - Paroxysmal Atrial Tachycardia + - Pelvic Floor Muscle Weakness + - Pelvic Infection + - Pelvic Pain + - Pelvic Soft Tissue Necrosis + - Penile Infection + - Penile Pain + - Perforation Bile Duct + - Pericardial Effusion + - Pericardial Tamponade + - Pericarditis + - Perineal Pain + - Periodontal Disease + - Periorbital Edema + - Periorbital Infection + - Peripheral Ischemia + - Peripheral Motor Neuropathy + - Peripheral Nerve Infection + - Peripheral Sensory Neuropathy + - Peritoneal Infection + - Peritoneal Necrosis + - Personality Change + - Phantom Pain + - Pharyngeal Anastomotic Leak + - Pharyngeal Fistula + - Pharyngeal Hemorrhage + - Pharyngeal Mucositis + - Pharyngeal Necrosis + - Pharyngeal Stenosis + - Pharyngitis + - Pharyngolaryngeal Pain + - Phlebitis + - Phlebitis Infective + - Photophobia + - Photosensitivity + - Platelet Count Decreased + - Pleural Effusion + - Pleural Hemorrhage + - Pleural Infection + - Pleuritic Pain + - Pneumonitis + - Pneumothorax + - Portal Hypertension + - Portal Vein Thrombosis + - Postnasal Drip + - Postoperative Hemorrhage + - Postoperative Thoracic Procedure Complication + - Precocious Puberty + - Pregnancy, Puerperium and Perinatal Conditions - Other + - Premature Delivery + - Premature Menopause + - Presyncope + - Proctitis + - Productive Cough + - Prolapse of Intestinal Stoma + - Prolapse of Urostomy + - Prostate Infection + - Prostatic Hemorrhage + - Prostatic Obstruction + - Prostatic Pain + - Proteinuria + - Pruritus + - Psychiatric Disorders - Other + - Psychosis + - Pulmonary Edema + - Pulmonary Fibrosis + - Pulmonary Fistula + - Pulmonary Hypertension + - Pulmonary Valve Disease + - Purpura + - Pyramidal Tract Syndrome + - Radiation Recall Reaction (Dermatologic) + - Radiculitis + - Rash Acneiform + - Rash Maculo-Papular + - Rash Pustular + - Rash/Desquamation + - Rectal Anastomotic Leak + - Rectal Fistula + - Rectal Hemorrhage + - Rectal Mucositis + - Rectal Necrosis + - Rectal Obstruction + - Rectal Pain + - Rectal Perforation + - Rectal Stenosis + - Rectal Ulcer + - Recurrent Laryngeal Nerve Palsy + - Renal and Urinary Disorders - Other + - Renal Calculi + - Renal Colic + - Renal Failure + - Renal Hemorrhage + - Reproductive System and Breast Disorders - Other + - Respiratory Failure + - Respiratory, Thoracic and Mediastinal Disorders - Other + - Restlessness + - Restrictive Cardiomyopathy + - Retinal Detachment + - Retinal Tear + - Retinal Vascular Disorder + - Retinoic Acid Syndrome + - Retinopathy + - Retroperitoneal Hemorrhage + - Reversible Posterior Leukoencephalopathy Syndrome + - Rhinitis Infective + - Right Ventricular Dysfunction + - Salivary Duct Inflammation + - Salivary Gland Fistula + - Salivary Gland Infection + - Scalp Pain + - Scleral Disorder + - Scoliosis + - Scrotal Infection + - Scrotal Pain + - Seizure + - Sepsis + - Seroma + - Serum Amylase Increased + - Serum Sickness + - Sick Sinus Syndrome + - Sinus Bradycardia + - Sinus Disorder + - Sinus Pain + - Sinus Tachycardia + - Sinusitis + - Skin and Subcutaneous Tissue Disorders - Other + - Skin Atrophy + - Skin Hyperpigmentation + - Skin Hypopigmentation + - Skin Induration + - Skin Infection + - Skin Ulceration + - Sleep Apnea + - Small Intestinal Anastomotic Leak + - Small Intestinal Mucositis + - Small Intestinal Obstruction + - Small Intestinal Perforation + - Small Intestinal Stenosis + - Small Intestine Infection + - Small Intestine Ulcer + - Sneezing + - Social Circumstances - Other + - Soft Tissue Infection + - Soft Tissue Necrosis Lower Limb + - Soft Tissue Necrosis Upper Limb + - Somnolence + - Sore Throat + - Spasticity + - Spermatic Cord Anastomotic Leak + - Spermatic Cord Hemorrhage + - Spermatic Cord Obstruction + - Spinal Fracture + - Spleen Disorder + - Splenic Infection + - Stenosis of Gastrointestinal Stoma + - Stevens-Johnson Syndrome + - Stoma Site Infection + - Stomach Pain + - Stomal Ulcer + - Stridor + - Stroke + - Sudden Death NOS + - Suicidal Ideation + - Suicide Attempt + - Superficial Soft Tissue Fibrosis + - Superficial Thrombophlebitis + - Superior Vena Cava Syndrome + - Supraventricular Tachycardia + - Surgical and Medical Procedures - Other + - Syncope + - Telangiectasia + - Testicular Disorder + - Testicular Hemorrhage + - Testicular Pain + - Thromboembolic Event + - Thrombotic Thrombocytopenic Purpura + - Tinnitus + - Tooth Development Disorder + - Tooth Discoloration + - Tooth Infection + - Toothache + - Toxic Epidermal Necrolysis + - Tracheal Fistula + - Tracheal Hemorrhage + - Tracheal Mucositis + - Tracheal Obstruction + - Tracheal Stenosis + - Tracheitis + - Tracheostomy Site Bleeding + - Transient Ischemic Attacks + - Treatment Related Secondary Malignancy + - Tremor + - Tricuspid Valve Disease + - Trigeminal Nerve Disorder + - Trismus + - Tumor Lysis Syndrome + - Tumor Pain + - Typhlitis + - Unequal Limb Length + - Unintended Pregnancy + - Upper Gastrointestinal Hemorrhage + - Upper Respiratory Infection + - Ureteral Obstruction + - Ureteric Anastomotic Leak + - Urethral Anastomotic Leak + - Urethral Infection + - Urinary Fistula + - Urinary Frequency + - Urinary Incontinence + - Urinary Retention + - Urinary Tract Infection + - Urinary Tract Obstruction + - Urinary Tract Pain + - Urinary Urgency + - Urine Discoloration + - Urine Output Decreased + - Urostomy Leak + - Urostomy Obstruction + - Urostomy Site Bleeding + - Urostomy Stenosis + - Urticaria + - Uterine Anastomotic Leak + - Uterine Fistula + - Uterine Hemorrhage + - Uterine Infection + - Uterine Obstruction + - Uterine Pain + - Uterine Perforation + - Uveitis + - Vaginal Anastomotic Leak + - Vaginal Discharge + - Vaginal Dryness + - Vaginal Fistula + - Vaginal Hemorrhage + - Vaginal Infection + - Vaginal Inflammation + - Vaginal Obstruction + - Vaginal Pain + - Vaginal Perforation + - Vaginal Stricture + - Vaginismus + - Vagus Nerve Disorder + - Vas Deferens Anastomotic Leak + - Vascular Access Complication + - Vascular Disorders - Other + - Vasculitis + - Vasovagal Reaction + - Venous Injury + - Ventricular Arrhythmia + - Ventricular Fibrillation + - Ventricular Tachycardia + - Vertigo + - Vestibular Disorder + - Virilization + - Visceral Arterial Ischemia + - Vital Capacity Abnormal + - Vitreous Hemorrhage + - Voice Alteration + - Vomiting + - Vulval Infection + - Watering Eyes + - Weight Gain + - Weight Loss + - Wheezing + - White Blood Cell Decreased + - Wolff-Parkinson-White Syndrome + - Wound Complication + - Wound Dehiscence + - Wound Infection + - Wrist Fracture + - Unknown + - Not Reported + + adverse_event_grade: + $ref: + - "_terms.yaml#/adverse_event_grade/common" + enum: + - Grade 1 + - Grade 2 + - Grade 3 + - Grade 4 + - Grade 5 + - Unknown + - Not Reported + + aids_risk_factors: + $ref: + - "_terms.yaml#/aids_risk_factors/common" + enum: + - Candidiasis + - Coccidioidomycosis + - Cryptococcosis + - Cryptosporidiosis, Chronic Intestinal + - Cytomegalovirus + - Encephalopathy + - Herpes Simplex Virus + - Histoplasmosis + - Isosporiasis + - Mycobacterium avium Complex + - Mycobacterium tuberculosis + - Mycobacterium, NOS + - Nocardiosis + - Pneumocystis Pneumonia + - Pneumonia, NOS + - Progressive Multifocal Leukoencephalopathy + - Salmonella Septicemia + - Toxoplasmosis + - Wasting Syndrome + + barretts_esophagus_goblet_cells_present: + $ref: + - "_terms.yaml#/barretts_esophagus_goblet_cells_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + bmi: + $ref: + - "_terms.yaml#/bmi/common" + type: number + minimum: 0 + + body_surface_area: + $ref: + - "_terms.yaml#/body_surface_area/common" + type: number + minimum: 0 + + cause_of_response: + $ref: + - "_terms.yaml#/cause_of_response/common" + type: string + + cd4_count: + $ref: + - "_terms.yaml#/cd4_count/common" + type: number + minimum: 0 + + cdc_hiv_risk_factors: + $ref: + - "_terms.yaml#/cdc_hiv_risk_factors/common" + enum: + - Hemophiliac + - Heterosexual Contact + - Homosexual Contact + - Intravenous Drug User + - None + - Transfusion Recipient + - Unknown + - Not Reported + enumDef: + None: + $ref: + - "_terms_enum.yaml#/none/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + comorbidities: + $ref: + - "_terms.yaml#/comorbidities/common" + type: array + items: + enum: + - Abnormal Glucose Level + - Acute Renal Failure + - Adenocarcinoma + - Adenomatous Polyposis Coli + - Adrenocortical Insufficiency + - Allergies + - Alpha-1 Antitrypsin + - Anemia + - Anxiety + - Arrhythmia + - Arthritis + - Asthma + - Ataxia-telangiectasia + - Atrial Fibrillation + - Autoimmune Lymphoproliferative Syndrome (ALPS) + - Avascular Necrosis + - Bacteroides fragilis + - Barrett's Esophagus + - Basal Cell Carcinoma + - Beckwith-Wiedemann + - Behcet's Disease + - Biliary Disorder + - Blood Clots + - Bone Fracture(s) + - Bronchitis + - Calcium Channel Blockers + - Cancer + - Cataracts + - Celiac Disease + - Cerebrovascular Disease + - Chlamydia + - Chloroma + - Cholelithiasis + - Chronic Fatigue Syndrome + - Chronic Pancreatitis + - Chronic Renal Failure + - Chronic Systemic Steroid Use + - Cirrhosis, Unknown Etiology + - Clonal Hematopoiesis + - CNS Infection + - Colon Polyps + - Common Variable Immunodeficiency + - Congestive Heart Failure (CHF) + - Connective Tissue Disorder + - COPD + - Coronary Artery Disease + - Crohn's Disease + - Cryptococcal Meningitis + - Cryptogenic Organizing Pneumonia + - Cytomegalovirus (CMV) + - Deep Vein Thrombosis / Thromboembolism + - Denys-Drash Syndrome + - Depression + - Dermatomyosis + - Diabetes + - Diabetes, Type II + - Diabetic Neuropathy + - Diet Controlled Diabetes + - Diverticulitis + - Down Syndrome + - DVT/PE + - Dyslipidemia + - EBV Lymphoproliferation + - Eczema + - Epilepsy + - Epstein-Barr Virus + - Familial Adenomatous Polyposis + - Fanconi Anemia + - Fibromyalgia + - Fibrosis + - Gastritis + - Gastroesophageal Reflux Disease + - GERD + - Glaucoma + - Glycogen Storage Disease + - Gonadal Dysfunction + - Gorlin Syndrome + - Gout + - H. pylori Infection + - Hashimoto's Thyroiditis + - Headache + - Heart Disease + - Hemihypertrophy + - Hemorrhagic Cystitis + - Hepatitis + - Hepatitis A Infection + - Hepatitis B Infection + - Hepatitis C Infection + - Hepatitis, Chronic + - Hereditary Non-polyposis Colon Cancer + - Herpes + - Herpes Zoster + - High Grade Liver Dysplastic Nodule + - HIV / AIDS + - Hodgkin Lymphoma + - Human Papillomavirus Infection + - HUS/TTP + - Hypercalcemia + - Hypercholesterolemia + - Hyperglycemia + - Hyperlipidemia + - Hypertension + - Hypospadias + - Hypothyroidism + - Inflammatory Bowel Disease + - Insulin Controlled Diabetes + - Interstitial Pneumontis or ARDS + - Intraductal Papillary Mucinous Neoplasm + - Iron Overload + - Ischemic Heart Disease + - ITP + - Joint Replacement + - Kidney Disease + - Li-Fraumeni Syndrome + - Liver Cirrhosis (Liver Disease) + - Liver Toxicity (Non-Infectious) + - Low Grade Liver Dysplastic Nodule + - Lupus + - Lymphamatoid Papulosis + - Lymphocytic Meningitis + - Lynch Syndrome + - MAI + - Malaria + - Metabolic Syndrome + - Methicillin-Resistant Staphylococcus aureus (MRSA) + - Myasthenia Gravis + - Mycobacterium avium Complex + - Myocardial Infarction + - Neuroendocrine Tumor + - Nonalcoholic Steatohepatitis + - Obesity + - Organ transplant (site) + - Osteoarthritis + - Osteoporosis or Osteopenia + - Other Cancer Within 5 Years + - Other Nonmalignant Systemic Disease + - Other Pulmonary Complications + - Pain (Various) + - Pancreatitis + - Peptic Ulcer (Ulcer) + - Peripheral Neuropathy + - Peripheral Vascular Disease + - Peutz-Jeghers Disease + - Pneumocystis Pneumonia + - Pneumonia, NOS + - Polycystic Ovarian Syndrome (PCOS) + - Pregnancy in Patient or Partner + - Primary Sclerosing Cholangitis + - Psoriasis + - Pulmonary Fibrosis + - Pulmonary Hemorrhage + - Renal Dialysis + - Renal Failure (Requiring Dialysis) + - Renal Insufficiency + - Rheumatoid Arthritis + - Rheumatologic Disease + - Rubinstein-Taybi Syndrome + - Sarcoidosis + - Seizure + - Shingles + - Sjogren's Syndrome + - Sleep apnea + - Smoking + - Staph Osteomyelitis + - Staphylococcus aureus + - Steatosis + - Stroke + - Syphilis + - Thyroid Disease, Non-Cancer + - Transient Ischemic Attack + - Treponema pallidum + - Tuberculosis + - Turcot Syndrome + - Tyrosinemia + - Ulcerative Colitis + - Urinary Tract Infection + - Varicella Zoster Virus + - Wagr Syndrome + - Other + - Unknown + - Not Reported + enumDef: + Pneumonia, NOS: + $ref: + - "_terms_enum.yaml#/pneumonia_nos/common" + + comorbidity: + $ref: + - "_terms.yaml#/comorbidity/common" + enum: + - Abnormal Glucose Level + - Acute Renal Failure + - Adenocarcinoma + - Adenomatous Polyposis Coli + - Adrenocortical Insufficiency + - Allergies + - Alpha-1 Antitrypsin + - Anemia + - Anxiety + - Arrhythmia + - Arthritis + - Asthma + - Ataxia-telangiectasia + - Atrial Fibrillation + - Autoimmune Lymphoproliferative Syndrome (ALPS) + - Avascular Necrosis + - Bacteroides fragilis + - Barrett's Esophagus + - Basal Cell Carcinoma + - Beckwith-Wiedemann + - Behcet's Disease + - Biliary Disorder + - Blood Clots + - Bone Fracture(s) + - Bronchitis + - Calcium Channel Blockers + - Cancer + - Cataracts + - Celiac Disease + - Cerebrovascular Disease + - Chlamydia + - Chloroma + - Cholelithiasis + - Chronic Fatigue Syndrome + - Chronic Pancreatitis + - Chronic Renal Failure + - Chronic Systemic Steroid Use + - Cirrhosis, Unknown Etiology + - Clonal Hematopoiesis + - CNS Infection + - Colon Polyps + - Common Variable Immunodeficiency + - Congestive Heart Failure (CHF) + - Connective Tissue Disorder + - COPD + - Coronary Artery Disease + - Crohn's Disease + - Cryptococcal Meningitis + - Cryptogenic Organizing Pneumonia + - Cytomegalovirus (CMV) + - Deep Vein Thrombosis / Thromboembolism + - Denys-Drash Syndrome + - Depression + - Dermatomyosis + - Diabetes + - Diabetes, Type II + - Diabetic Neuropathy + - Diet Controlled Diabetes + - Diverticulitis + - Down Syndrome + - DVT/PE + - Dyslipidemia + - EBV Lymphoproliferation + - Eczema + - Epilepsy + - Epstein-Barr Virus + - Familial Adenomatous Polyposis + - Fanconi Anemia + - Fibromyalgia + - Fibrosis + - Gastritis + - Gastroesophageal Reflux Disease + - GERD + - Glaucoma + - Glycogen Storage Disease + - Gonadal Dysfunction + - Gorlin Syndrome + - Gout + - H. pylori Infection + - Hashimoto's Thyroiditis + - Headache + - Heart Disease + - Hemihypertrophy + - Hemorrhagic Cystitis + - Hepatitis + - Hepatitis A Infection + - Hepatitis B Infection + - Hepatitis C Infection + - Hepatitis, Chronic + - Hereditary Non-polyposis Colon Cancer + - Herpes + - Herpes Zoster + - High Grade Liver Dysplastic Nodule + - HIV / AIDS + - Hodgkin Lymphoma + - Human Papillomavirus Infection + - HUS/TTP + - Hypercalcemia + - Hypercholesterolemia + - Hyperglycemia + - Hyperlipidemia + - Hypertension + - Hypospadias + - Hypothyroidism + - Inflammatory Bowel Disease + - Insulin Controlled Diabetes + - Interstitial Pneumontis or ARDS + - Intraductal Papillary Mucinous Neoplasm + - Iron Overload + - Ischemic Heart Disease + - ITP + - Joint Replacement + - Kidney Disease + - Li-Fraumeni Syndrome + - Liver Cirrhosis (Liver Disease) + - Liver Toxicity (Non-Infectious) + - Low Grade Liver Dysplastic Nodule + - Lupus + - Lymphamatoid Papulosis + - Lymphocytic Meningitis + - Lynch Syndrome + - MAI + - Malaria + - Metabolic Syndrome + - Methicillin-Resistant Staphylococcus aureus (MRSA) + - Myasthenia Gravis + - Mycobacterium avium Complex + - Myocardial Infarction + - Neuroendocrine Tumor + - Nonalcoholic Steatohepatitis + - Obesity + - Organ transplant (site) + - Osteoarthritis + - Osteoporosis or Osteopenia + - Other Cancer Within 5 Years + - Other Nonmalignant Systemic Disease + - Other Pulmonary Complications + - Pain (Various) + - Pancreatitis + - Peptic Ulcer (Ulcer) + - Peripheral Neuropathy + - Peripheral Vascular Disease + - Peutz-Jeghers Disease + - Pneumocystis Pneumonia + - Polycystic Ovarian Syndrome (PCOS) + - Pregnancy in Patient or Partner + - Primary Sclerosing Cholangitis + - Psoriasis + - Pulmonary Fibrosis + - Pulmonary Hemorrhage + - Renal Dialysis + - Renal Failure (Requiring Dialysis) + - Renal Insufficiency + - Rheumatoid Arthritis + - Rheumatologic Disease + - Rubinstein-Taybi Syndrome + - Sarcoidosis + - Seizure + - Shingles + - Sjogren's Syndrome + - Sleep apnea + - Smoking + - Staph Osteomyelitis + - Staphylococcus aureus + - Steatosis + - Stroke + - Syphilis + - Thyroid Disease, Non-Cancer + - Transient Ischemic Attack + - Treponema pallidum + - Tuberculosis + - Turcot Syndrome + - Tyrosinemia + - Ulcerative Colitis + - Urinary Tract Infection + - Varicella Zoster Virus + - Wagr Syndrome + - Other + - Unknown + - Not Reported + enumDef: + Cancer: + $ref: + - "_terms_enum.yaml#/cancer/common" + Epstein-Barr Virus: + $ref: + - "_terms_enum.yaml#/epsteinbarr_virus/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + comorbidity_method_of_diagnosis: + $ref: + - "_terms.yaml#/comorbidity_method_of_diagnosis/common" + enum: + - Histology + - Pathology + - Radiology + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + days_to_adverse_event: + $ref: + - "_terms.yaml#/days_to_adverse_event/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_comorbidity: + $ref: + - "_terms.yaml#/days_to_comorbidity/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_first_event: + $ref: + - "_terms.yaml#/days_to_first_event/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_follow_up: + $ref: + - "_terms.yaml#/days_to_follow_up/common" + oneOf: + - type: integer + maximum: 32872 + minimum: -32872 + - type: "null" + + days_to_imaging: + $ref: + - "_terms.yaml#/days_to_imaging/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_progression: + $ref: + - "_terms.yaml#/days_to_progression/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_progression_free: + $ref: + - "_terms.yaml#/days_to_progression_free/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_recurrence: + $ref: + - "_terms.yaml#/days_to_recurrence/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_risk_factor: + $ref: + - "_terms.yaml#/days_to_risk_factor/common" + type: integer + maximum: 32872 + minimum: -32872 + + diabetes_treatment_type: + $ref: + - "_terms.yaml#/diabetes_treatment_type/common" + enum: + - Alpha-Glucosidase Inhibitor + - Biguanide + - Diet + - Injected Insulin + - Insulin + - Linagliptin + - Oral Hypoglycemic + - Sulfonylurea + - Thiazolidinedione + - Other + - Unknown + - Not Reported + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + discontiguous_lesion_count: + $ref: + - "_terms.yaml#/discontiguous_lesion_count/common" + type: integer + minimum: 0 + + disease_response: + $ref: + - "_terms.yaml#/disease_response/common" + enum: + - AJ-Adjuvant Therapy + - BED-Biochemical Evidence of Disease + - CPD-Clinical Progression + - CR-Complete Response + - CRU-Complete Response Unconfirmed + - DU-Disease Unchanged + - IMR-Immunoresponse + - IPD-Immunoprogression + - MR-Minimal/Marginal response + - MX-Mixed Response + - Non-CR/Non-PD-Non-CR/Non-PD + - NPB-No Palliative Benefit + - NR-No Response + - PA-Palliative Therapy + - PB-Palliative Benefit + - PD-Progressive Disease + - PDM-Persistent Distant Metastasis + - PLD-Persistent Locoregional Disease + - PPD-Pseudoprogression + - PR-Partial Response + - PSR-Pseudoresponse + - RD-Responsive Disease + - RP-Response + - RPD-Radiographic Progressive Disease + - sCR-Stringent Complete Response + - SD-Stable Disease + - SPD-Surgical Progression + - TE-Too Early + - TF-Tumor Free + - VGPR-Very Good Partial Response + - WT-With Tumor + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + dlco_ref_predictive_percent: + $ref: + - "_terms.yaml#/dlco_ref_predictive_percent/common" + type: number + maximum: 100 + minimum: 0 + + ecog_performance_status: + $ref: + - "_terms.yaml#/ecog_performance_status/common" + enum: + - "0" + - "1" + - "2" + - "3" + - "4" + - "5" + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + evidence_of_progression_type: + $ref: + - "_terms.yaml#/evidence_of_progression_type/common" + enum: + - Biopsy with Histologic Confirmation + - Convincing Image Source + - Histologic Confirmation + - Physical Examination + - Positive Biomarker(s) + - Unknown + - Not Reported + + evidence_of_recurrence_type: + $ref: + - "_terms.yaml#/evidence_of_recurrence_type/common" + enum: + - Biopsy with Histologic Confirmation + - Convincing Image Source + - Histologic Confirmation + - Physical Examination + - Positive Biomarker(s) + - Unknown + - Not Reported + + eye_color: + $ref: + - "_terms.yaml#/eye_color/common" + enum: + - Amber + - Blue + - Brown + - Gray + - Green + - Hazel + - Red & Violet + - Other + - Not Reported + + fev1_fvc_post_bronch_percent: + $ref: + - "_terms.yaml#/fev1_fvc_post_bronch_percent/common" + type: number + maximum: 100 + minimum: 0 + + fev1_fvc_pre_bronch_percent: + $ref: + - "_terms.yaml#/fev1_fvc_pre_bronch_percent/common" + type: number + maximum: 100 + minimum: 0 + + fev1_ref_post_bronch_percent: + $ref: + - "_terms.yaml#/fev1_ref_post_bronch_percent/common" + type: number + maximum: 100 + minimum: 0 + + fev1_ref_pre_bronch_percent: + $ref: + - "_terms.yaml#/fev1_ref_pre_bronch_percent/common" + type: number + maximum: 100 + minimum: 0 + + first_event: + $ref: + - "_terms.yaml#/first_event/common" + enum: + - Censored + - Death + - Death without Remission + - Event + - Induction Death + - Induction Failure + - None + - Presented with Metastases + - Progression + - Recurrence + - Relapse + - Second Malignant Neoplasm + - Other + - Unknown + - Not Reported + + haart_treatment_indicator: + $ref: + - "_terms.yaml#/haart_treatment_indicator/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + height: + $ref: + - "_terms.yaml#/height/common" + type: number + minimum: 0 + + hepatitis_sustained_virological_response: + $ref: + - "_terms.yaml#/hepatitis_sustained_virological_response/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + histologic_progression: + $ref: + - "_terms.yaml#/histologic_progression/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + + history_of_tumor: + $ref: + - "_terms.yaml#/history_of_tumor/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + history_of_tumor_type: + $ref: + - "_terms.yaml#/history_of_tumor_type/common" + enum: + - Colorectal Cancer + - Lower Grade Glioma + - Phenochromocytoma or Paraganglioma + - Unknown + - Not Reported + + hiv_viral_load: + $ref: + - "_terms.yaml#/hiv_viral_load/common" + type: number + minimum: 0 + + hormonal_contraceptive_type: + $ref: + - "_terms.yaml#/hormonal_contraceptive_type/common" + enum: + - Progestin + - Progestin and Estrogen + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hormonal_contraceptive_use: + $ref: + - "_terms.yaml#/hormonal_contraceptive_use/common" + enum: + - Current User + - Former User + - Never Used + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hormone_replacement_therapy_type: + $ref: + - "_terms.yaml#/hormone_replacement_therapy_type/common" + enum: + - Estrogen only + - Progesterone and Estrogen + - Progesterone only + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hpv_positive_type: + $ref: + - "_terms.yaml#/hpv_positive_type/common" + enum: + - "16" + - "18" + - "26" + - "31" + - "33" + - "35" + - "39" + - "45" + - "51" + - "52" + - "53" + - "56" + - "58" + - "59" + - "63" + - "66" + - "68" + - "70" + - "73" + - "82" + - Other + - Unknown + - Not Reported + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hysterectomy_margins_involved: + $ref: + - "_terms.yaml#/hysterectomy_margins_involved/common" + enum: + - Bladder + - Macroscopic Parametrium + - Microscopic Parametrium + - None + - Vagina + - Unknown + - Not Reported + enumDef: + None: + $ref: + - "_terms_enum.yaml#/none/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hysterectomy_type: + $ref: + - "_terms.yaml#/hysterectomy_type/common" + enum: + - Hysterectomy, NOS + - Not performed + - Radical Hysterectomy + - Simple Hysterectomy + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + imaging_anatomic_site: + $ref: + - "_terms.yaml#/imaging_anatomic_site/common" + type: array + items: + enum: + - Abdomen + - Cervix Uteri + - Lymph Node + - Pelvis + - Pleura + - Unknown + - Not Reported + enumDef: + Lymph Node: + $ref: + - "_terms_enum.yaml#/lymph_node_nos/common" + + imaging_findings: + $ref: + - "_terms.yaml#/imaging_findings/common" + enum: + - Bladder Involvement + - Carcinomatosis + - Distant Metastasis + - Equivocal + - Extra-Pelvic Metastatic Disease + - Extraprostatic Extension, Localized + - Extraprostatic Extension, Regional Lymphadenopathy + - Kidney Involvement + - Liver Involvement + - Lung Involvement + - No Evidence of Extraprostatic Extension + - Normal + - Paraaortic Lymph Node Involvement + - Parametrium Involvement + - Pelvic Lymph Node Involvement + - Retroperitoneal Lymph Node Involvement + - Supraclavicular Lymph Node Involvement + - Vena Cava Involvement/Thrombus + - Unknown + - Not Reported + + imaging_result: + $ref: + - "_terms.yaml#/imaging_result/common" + enum: + - Indeterminate + - Negative + - Not Performed + - Positive + - Unknown + - Not Reported + enumDef: + Negative: + $ref: + - "_terms_enum.yaml#/negative/common" + Positive: + $ref: + - "_terms_enum.yaml#/positive/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + imaging_suv: + $ref: + - "_terms.yaml#/imaging_suv/common" + type: number + + imaging_suv_max: + $ref: + - "_terms.yaml#/imaging_suv_max/common" + type: number + + imaging_type: + $ref: + - "_terms.yaml#/imaging_type/common" + enum: + - 99mTc Bone Scintigraphy + - Bone Scan, NOS + - CT Scan + - MRI + - PET + - Ultrasound + - Unknown + - Not Reported + enumDef: + Ultrasound: + $ref: + - "_terms_enum.yaml#/ultrasound/common" + + immunosuppressive_treatment_type: + $ref: + - "_terms.yaml#/immunosuppressive_treatment_type/common" + enum: + - Anti-TNF Therapy + - Azathioprine + - Cyclophosphamide + - Methotrexate + - None + - Other + - Unknown + - Not Reported + enumDef: + None: + $ref: + - "_terms_enum.yaml#/none/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + karnofsky_performance_status: + $ref: + - "_terms.yaml#/karnofsky_performance_status/common" + enum: + - "0" + - "10" + - "20" + - "30" + - "40" + - "50" + - "60" + - "70" + - "80" + - "90" + - "100" + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + menopause_status: + $ref: + - "_terms.yaml#/menopause_status/common" + enum: + - Perimenopausal + - Postmenopausal + - Premenopausal + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + nadir_cd4_count: + $ref: + - "_terms.yaml#/nadir_cd4_count/common" + type: number + minimum: 0 + + pancreatitis_onset_year: + $ref: + - "_terms.yaml#/pancreatitis_onset_year/common" + type: integer + minimum: 1900 + + peritoneal_washing_results: + $ref: + - "_terms.yaml#/peritoneal_washing_results/common" + enum: + - Negative + - Positive + - Unknown + - Not Reported + + pregnancy_count: + $ref: + - "_terms.yaml#/pregnancy_count/common" + type: integer + minimum: 0 + + pregnancy_outcome: + $ref: + - "_terms.yaml#/pregnancy_outcome/common" + enum: + - Ectopic Pregnancy + - Induced Abortion + - Live Birth + - Miscarriage + - Spontaneous Abortion + - Stillbirth + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + procedures_performed: + $ref: + - "_terms.yaml#/procedures_performed/common" + enum: + - Colonoscopy + - Endoscopy + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + progression_or_recurrence: + $ref: + - "_terms.yaml#/progression_or_recurrence/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + progression_or_recurrence_anatomic_site: + $ref: + - "_terms.yaml#/progression_or_recurrence_anatomic_site/common" + enum: + - Abdomen, NOS + - Abdominal esophagus + - Accessory sinus, NOS + - Acoustic nerve + - Adrenal gland, NOS + - Ampulla of Vater + - Anal canal + - Anterior 2/3 of tongue, NOS + - Anterior floor of mouth + - Anterior mediastinum + - Anterior surface of epiglottis + - Anterior wall of bladder + - Anterior wall of nasopharynx + - Anus, NOS + - Aortic body and other paraganglia + - Appendix + - Ascending colon + - Autonomic nervous system, NOS + - Axillary tail of breast + - Base of tongue, NOS + - Biliary tract, NOS + - Bladder neck + - Bladder, NOS + - Blood + - Body of pancreas + - Body of penis + - Body of stomach + - Bone marrow + - Bone of limb, NOS + - Bone, NOS + - Bones of skull and face and associated joints + - Border of tongue + - Brain stem + - Brain, NOS + - Branchial cleft + - Breast, NOS + - Broad ligament + - Cardia, NOS + - Carotid body + - Cauda equina + - Cecum + - Central portion of breast + - Cerebellum, NOS + - Cerebral meninges + - Cerebrum + - Cervical esophagus + - Cervix uteri + - Cheek mucosa + - Choroid + - Ciliary body + - Clitoris + - Cloacogenic zone + - Colon, NOS + - Commissure of lip + - Conjunctiva + - Connective, subcutaneous and other soft tissues of abdomen + - Connective, subcutaneous and other soft tissues of head, face, and neck + - Connective, subcutaneous and other soft tissues of lower limb and hip + - Connective, subcutaneous and other soft tissues of pelvis + - Connective, subcutaneous and other soft tissues of thorax + - Connective, subcutaneous and other soft tissues of trunk, NOS + - Connective, subcutaneous and other soft tissues of upper limb and shoulder + - Connective, subcutaneous and other soft tissues, NOS + - Cornea, NOS + - Corpus uteri + - Cortex of adrenal gland + - Cranial nerve, NOS + - Craniopharyngeal duct + - Descended testis + - Descending colon + - Dome of bladder + - Dorsal surface of tongue, NOS + - Duodenum + - Endocervix + - Endocrine gland, NOS + - Endometrium + - Epididymis + - Esophagus, NOS + - Ethmoid sinus + - Exocervix + - External ear + - External lip, NOS + - External lower lip + - External upper lip + - Extrahepatic bile duct + - Eye, NOS + - Eyelid + - Fallopian tube + - Female genital tract, NOS + - Floor of mouth, NOS + - Frontal lobe + - Frontal sinus + - Fundus of stomach + - Fundus uteri + - Gallbladder + - Gastric antrum + - Gastrointestinal tract, NOS + - Glans penis + - Glottis + - Greater curvature of stomach, NOS + - Gum, NOS + - Hard palate + - Head of pancreas + - Head, face or neck, NOS + - Heart + - Hematopoietic system, NOS + - Hepatic flexure of colon + - Hypopharyngeal aspect of aryepiglottic fold + - Hypopharynx, NOS + - Ileum + - Ill-defined sites within respiratory system + - Intestinal tract, NOS + - Intra-abdominal lymph nodes + - Intrahepatic bile duct + - Intrathoracic lymph nodes + - Islets of Langerhans + - Isthmus uteri + - Jejunum + - Kidney, NOS + - Labium majus + - Labium minus + - Lacrimal gland + - Laryngeal cartilage + - Larynx, NOS + - Lateral floor of mouth + - Lateral wall of bladder + - Lateral wall of nasopharynx + - Lateral wall of oropharynx + - Lesser curvature of stomach, NOS + - Lingual tonsil + - Lip, NOS + - Liver + - Long bones of lower limb and associated joints + - Long bones of upper limb, scapula and associated joints + - Lower gum + - Lower limb, NOS + - Lower lobe, lung + - Lower third of esophagus + - Lower-inner quadrant of breast + - Lower-outer quadrant of breast + - Lung, NOS + - Lymph node, NOS + - Lymph nodes of axilla or arm + - Lymph nodes of head, face and neck + - Lymph nodes of inguinal region or leg + - Lymph nodes of multiple regions + - Main bronchus + - Major salivary gland, NOS + - Male genital organs, NOS + - Mandible + - Maxillary sinus + - Meckel diverticulum + - Mediastinum, NOS + - Medulla of adrenal gland + - Meninges, NOS + - Middle ear + - Middle lobe, lung + - Middle third of esophagus + - Mouth, NOS + - Mucosa of lip, NOS + - Mucosa of lower lip + - Mucosa of upper lip + - Myometrium + - Nasal cavity + - Nasopharynx, NOS + - Nervous system, NOS + - Nipple + - Occipital lobe + - Olfactory nerve + - Optic nerve + - Orbit, NOS + - Oropharynx, NOS + - Other ill-defined sites + - Other specified parts of female genital organs + - Other specified parts of male genital organs + - Other specified parts of pancreas + - Ovary + - Overlapping lesion of accessory sinuses + - Overlapping lesion of biliary tract + - Overlapping lesion of bladder + - Overlapping lesion of bones, joints and articular cartilage + - Overlapping lesion of bones, joints and articular cartilage of limbs + - Overlapping lesion of brain + - Overlapping lesion of brain and central nervous system + - Overlapping lesion of breast + - Overlapping lesion of cervix uteri + - Overlapping lesion of colon + - Overlapping lesion of connective, subcutaneous and other soft tissues + - Overlapping lesion of corpus uteri + - Overlapping lesion of digestive system + - Overlapping lesion of endocrine glands and related structures + - Overlapping lesion of esophagus + - Overlapping lesion of eye and adnexa + - Overlapping lesion of female genital organs + - Overlapping lesion of floor of mouth + - Overlapping lesion of heart, mediastinum and pleura + - Overlapping lesion of hypopharynx + - Overlapping lesion of ill-defined sites + - Overlapping lesion of larynx + - Overlapping lesion of lip + - Overlapping lesion of lip, oral cavity and pharynx + - Overlapping lesion of lung + - Overlapping lesion of major salivary glands + - Overlapping lesion of male genital organs + - Overlapping lesion of nasopharynx + - Overlapping lesion of other and unspecified parts of mouth + - Overlapping lesion of palate + - Overlapping lesion of pancreas + - Overlapping lesion of penis + - Overlapping lesion of peripheral nerves and autonomic nervous system + - Overlapping lesion of rectum, anus and anal canal + - Overlapping lesion of respiratory system and intrathoracic organs + - Overlapping lesion of retroperitoneum and peritoneum + - Overlapping lesion of skin + - Overlapping lesion of small intestine + - Overlapping lesion of stomach + - Overlapping lesion of tongue + - Overlapping lesion of tonsil + - Overlapping lesion of urinary organs + - Overlapping lesion of vulva + - Overlapping lesions of oropharynx + - Palate, NOS + - Pancreas, NOS + - Pancreatic duct + - Parametrium + - Parathyroid gland + - Paraurethral gland + - Parietal lobe + - Parotid gland + - Pelvic bones, sacrum, coccyx and associated joints + - Pelvic lymph nodes + - Pelvis, NOS + - Penis, NOS + - Peripheral nerves and autonomic nervous system of abdomen + - Peripheral nerves and autonomic nervous system of head, face, and neck + - Peripheral nerves and autonomic nervous system of lower limb and hip + - Peripheral nerves and autonomic nervous system of pelvis + - Peripheral nerves and autonomic nervous system of thorax + - Peripheral nerves and autonomic nervous system of trunk, NOS + - Peripheral nerves and autonomic nervous system of upper limb and shoulder + - Peritoneum, NOS + - Pharynx, NOS + - Pineal gland + - Pituitary gland + - Placenta + - Pleura, NOS + - Postcricoid region + - Posterior mediastinum + - Posterior wall of bladder + - Posterior wall of hypopharynx + - Posterior wall of nasopharynx + - Posterior wall of oropharynx + - Prepuce + - Prostate gland + - Pylorus + - Pyriform sinus + - Rectosigmoid junction + - Rectum, NOS + - Renal pelvis + - Reticuloendothelial system, NOS + - Retina + - Retromolar area + - Retroperitoneum + - Rib, sternum, clavicle and associated joints + - Round ligament + - Scrotum, NOS + - Short bones of lower limb and associated joints + - Short bones of upper limb and associated joints + - Sigmoid colon + - Skin of lip, NOS + - Skin of lower limb and hip + - Skin of other and unspecified parts of face + - Skin of scalp and neck + - Skin of trunk + - Skin of upper limb and shoulder + - Skin, NOS + - Small intestine, NOS + - Soft palate, NOS + - Specified parts of peritoneum + - Spermatic cord + - Sphenoid sinus + - Spinal cord + - Spinal meninges + - Spleen + - Splenic flexure of colon + - Stomach, NOS + - Subglottis + - Sublingual gland + - Submandibular gland + - Superior wall of nasopharynx + - Supraglottis + - Tail of pancreas + - Temporal lobe + - Testis, NOS + - Thoracic esophagus + - Thorax, NOS + - Thymus + - Thyroid gland + - Tongue, NOS + - Tonsil, NOS + - Tonsillar fossa + - Tonsillar pillar + - Trachea + - Transverse colon + - Trigone of bladder + - Undescended testis + - Unknown primary site + - Upper gum + - Upper limb, NOS + - Upper lobe, lung + - Upper respiratory tract, NOS + - Upper third of esophagus + - Upper-inner quadrant of breast + - Upper-outer quadrant of breast + - Urachus + - Ureter + - Ureteric orifice + - Urethra + - Urinary system, NOS + - Uterine adnexa + - Uterus, NOS + - Uvula + - Vagina, NOS + - Vallecula + - Ventral surface of tongue, NOS + - Ventricle, NOS + - Vertebral column + - Vestibule of mouth + - Vulva, NOS + - Waldeyer ring + - Unknown + - Not Reported + enumDef: + Bone marrow: + $ref: + - "_terms_enum.yaml#/bone_marrow/common" + Frontal lobe: + $ref: + - "_terms_enum.yaml#/frontal_lobe/common" + Occipital lobe: + $ref: + - "_terms_enum.yaml#/occipital_lobe/common" + Parietal lobe: + $ref: + - "_terms_enum.yaml#/parietal_lobe/common" + Temporal lobe: + $ref: + - "_terms_enum.yaml#/temporal_lobe/common" + Uterine adnexa: + $ref: + - "_terms_enum.yaml#/uterine_adnexa/common" + Vulva, NOS: + $ref: + - "_terms_enum.yaml#/vulva_nos/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + progression_or_recurrence_type: + $ref: + - "_terms.yaml#/progression_or_recurrence_type/common" + enum: + - Biochemical + - Distant + - Local + - Locoregional + - Regional + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + recist_targeted_regions_number: + $ref: + - "_terms.yaml#/recist_targeted_regions_number/common" + type: integer + minimum: 0 + + recist_targeted_regions_sum: + $ref: + - "_terms.yaml#/recist_targeted_regions_sum/common" + type: number + minimum: 0 + + reflux_treatment_type: + $ref: + - "_terms.yaml#/reflux_treatment_type/common" + enum: + - Antacids + - H2 Blockers + - Medically Treated + - No Treatment + - Proton Pump Inhibitors + - Surgically Treated + - Unknown + - Not Reported + - Not Applicable + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + risk_factor: + $ref: + - "_terms.yaml#/risk_factor/common" + enum: + - Abnormal Glucose Level + - Adenomyosis + - Adenosis (Atypical Adenomatous Hyperplasia) + - Alcohol Consumption + - Alcoholic Liver Disease + - Allergy, Animal, NOS + - Allergy, Ant + - Allergy, Bee + - Allergy, Cat + - Allergy, Dairy or Lactose + - Allergy, Dog + - Allergy, Eggs + - Allergy, Food, NOS + - Allergy, Fruit + - Allergy, Meat + - Allergy, Mold or Dust + - Allergy, Nuts + - Allergy, Processed Foods + - Allergy, Seafood + - Allergy, Wasp + - Alpha-1 Antitrypsin Deficiency + - Altered Mental Status + - Androgen Excess + - Anemia + - Asthma + - Ataxia-telangiectasia + - Autoimmune Atrophic Chronic Gastritis + - Autoimmune Lymphoproliferative Syndrome (ALPS) + - Bacteroides fragilis + - BAP1 Tumor Predisposition Syndrome + - Barrett's Esophagus + - Beckwith-Wiedemann + - Behcet's Disease + - Benign Prostatic Hyperplasia + - Birt-Hogg-Dube Syndrome + - BRCA Family History + - Cancer + - Chlamydia + - Chloroma + - Cholelithiasis + - Chronic Hepatitis + - Chronic Kidney Disease + - Chronic Pancreatitis + - Chronic Systemic Steroid Use + - Cirrhosis + - Colon Polyps + - Colonization, Bacterial + - Colonization, Fungal + - Common variable immune deficiency (CVID) + - Cortisol Excess + - Cowden Syndrome + - Cryptococcal Meningitis + - Cyst(s) + - Cytomegalovirus (CMV) + - Denys-Drash Syndrome + - Dermatomyosis + - Diabetes, NOS + - Diabetes, Type I + - Diabetes, Type II + - Diet + - Diverticulitis + - Down Syndrome + - EBV Lymphoproliferation + - Eczema + - Endometriosis + - Endosalpingiosis + - Epithelial Dysplasia + - Epithelial Hyperplasia + - Epstein-Barr Virus + - Escherichia coli + - Estrogen Excess + - Familial Adenomatous Polyposis + - Fanconi Anemia + - Fibrosis + - Gastric Polyp(s) + - Gastritis + - Gilbert's Syndrome + - Glomerular Disease + - Gorlin Syndrome + - H. pylori Infection + - Hashimoto's Thyroiditis + - Hay Fever + - Headache + - Helicobacter Pylori-Associated Gastritis + - Hematologic Disorder, NOS + - Hemihypertrophy + - Hemochromatosis + - Hepatic Encephalopathy + - Hepatitis A Infection + - Hepatitis B Infection + - Hepatitis C Infection + - Hepatitis, NOS + - Hereditary Breast Cancer + - Hereditary Hemorrhagic Telangiectasia + - Hereditary Kidney Oncocytoma + - Hereditary Leiomyomatosis and Renal Cell Carcinoma + - Hereditary Ovarian Cancer + - Hereditary Papillary Renal Cell Carcinoma + - Hereditary Prostate Cancer + - Hereditary Renal Cell Carcinoma + - Herpes Zoster + - High Grade Dysplasia + - High-grade Prostatic Intraepithelial Neoplasia (PIN) + - HIV + - Hodgkin Lymphoma + - Human Herpesvirus-6 (HHV-6) + - Human Herpesvirus-8 (HHV-8) + - Human Papillomavirus Infection + - Hypospadias + - Inflammation + - Inflammation, Hyperkeratosis + - Inherited Genetic Syndrome, NOS + - Intestinal Metaplasia + - Iron Overload + - Li-Fraumeni Syndrome + - Low Grade Dysplasia + - Lymphamatoid Papulosis + - Lymphocytic Meningitis + - Lymphocytic Thyroiditis + - Lynch Syndrome + - Malaria + - Metabolic Syndrome + - Mineralcorticoids Excess + - Motor / Movement Change + - Myasthenia Gravis + - Mycobacterium avium Complex + - Myelodysplastic Syndrome + - Neurocystericerosis + - Nodular Prostatic Hyperplasia + - Nonalcoholic Fatty Liver Disease + - Nonalcoholic Steatohepatitis + - None + - Obesity + - Oral Contraceptives + - Pancreatitis + - Parasitic Disease of Biliary Tract + - Pneumocystis Pneumonia + - Polycystic Ovarian Syndrome (PCOS) + - Primary Sclerosing Cholangitis + - Recurrent Pyogenic Cholangitis + - Reflux Disease + - Rheumatoid Arthritis + - Rubella + - Rubinstein-Taybi Syndrome + - Sarcoidosis + - Seizure + - Sensory Changes + - Serous tubal intraepithelial carcinoma (STIC) + - Shingles + - Sialadenitis + - Sjogren's Syndrome + - Skin Rash + - Squamous Metaplasia + - Staphylococcus aureus + - Steatosis + - Succinate Dehydrogenase-Deficient Renal Cell Carcinoma + - Syphilis + - Tattoo + - Thyroid Nodular Hyperplasia + - Tobacco, NOS + - Tobacco, Smokeless + - Tobacco, Smoking + - Treponema pallidum + - Tuberculosis + - Tuberous Sclerosis + - Tubulointerstitial Disease + - Tumor-associated Lymphoid Proliferation + - Turcot Syndrome + - Undescended Testis + - Varicella Zoster Virus + - Vascular Disease + - Vision Changes + - Von Hippel-Lindau Syndrome + - Wagr Syndrome + - Unknown + - Not Reported + enumDef: + Cancer: + $ref: + - "_terms_enum.yaml#/cancer/common" + Epstein-Barr Virus: + $ref: + - "_terms_enum.yaml#/epsteinbarr_virus/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + risk_factor_method_of_diagnosis: + $ref: + - "_terms.yaml#/risk_factor_method_of_diagnosis/common" + enum: + - Biochemical Assessment + - Both Clinical and Biochemical Assessments + - Clinical Assessment + - Not Reported + + risk_factor_treatment: + $ref: + - "_terms.yaml#/risk_factor_treatment/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + risk_factors: + $ref: + - "_terms.yaml#/risk_factors/common" + type: array + items: + enum: + - Abnormal Glucose Level + - Adenomyosis + - Adenosis (Atypical Adenomatous Hyperplasia) + - Alcohol Consumption + - Alcoholic Liver Disease + - Allergy, Animal, NOS + - Allergy, Ant + - Allergy, Bee + - Allergy, Cat + - Allergy, Dairy or Lactose + - Allergy, Dog + - Allergy, Eggs + - Allergy, Food, NOS + - Allergy, Fruit + - Allergy, Meat + - Allergy, Mold or Dust + - Allergy, Nuts + - Allergy, Processed Foods + - Allergy, Seafood + - Allergy, Wasp + - Alpha-1 Antitrypsin Deficiency + - Altered Mental Status + - Androgen Excess + - Anemia + - Asthma + - Ataxia-telangiectasia + - Autoimmune Atrophic Chronic Gastritis + - Autoimmune Lymphoproliferative Syndrome (ALPS) + - Bacteroides fragilis + - BAP1 Tumor Predisposition Syndrome + - Barrett's Esophagus + - Beckwith-Wiedemann + - Behcet's Disease + - Benign Prostatic Hyperplasia + - Birt-Hogg-Dube Syndrome + - BRCA Family History + - Cancer + - Chlamydia + - Chloroma + - Cholelithiasis + - Chronic Hepatitis + - Chronic Kidney Disease + - Chronic Pancreatitis + - Chronic Systemic Steroid Use + - Cirrhosis + - Colon Polyps + - Colonization, Bacterial + - Colonization, Fungal + - Common variable immune deficiency (CVID) + - Cortisol Excess + - Cowden Syndrome + - Cryptococcal Meningitis + - Cyst(s) + - Cytomegalovirus (CMV) + - Denys-Drash Syndrome + - Dermatomyosis + - Diabetes, NOS + - Diabetes, Type I + - Diabetes, Type II + - Diet + - Diverticulitis + - Down Syndrome + - EBV Lymphoproliferation + - Eczema + - Endometriosis + - Endosalpingiosis + - Epithelial Dysplasia + - Epithelial Hyperplasia + - Epstein-Barr Virus + - Escherichia coli + - Estrogen Excess + - Familial Adenomatous Polyposis + - Fanconi Anemia + - Fibrosis + - Gastric Polyp(s) + - Gastritis + - Gilbert's Syndrome + - Glomerular Disease + - Gorlin Syndrome + - H. pylori Infection + - Hashimoto's Thyroiditis + - Hay Fever + - Headache + - Helicobacter Pylori-Associated Gastritis + - Hematologic Disorder, NOS + - Hemihypertrophy + - Hemochromatosis + - Hepatic Encephalopathy + - Hepatitis A Infection + - Hepatitis B Infection + - Hepatitis C Infection + - Hepatitis, NOS + - Hereditary Breast Cancer + - Hereditary Hemorrhagic Telangiectasia + - Hereditary Kidney Oncocytoma + - Hereditary Leiomyomatosis and Renal Cell Carcinoma + - Hereditary Ovarian Cancer + - Hereditary Papillary Renal Cell Carcinoma + - Hereditary Prostate Cancer + - Hereditary Renal Cell Carcinoma + - Herpes Zoster + - High Grade Dysplasia + - High-grade Prostatic Intraepithelial Neoplasia (PIN) + - HIV + - Hodgkin Lymphoma + - Human Herpesvirus-6 (HHV-6) + - Human Herpesvirus-8 (HHV-8) + - Human Papillomavirus Infection + - Hypospadias + - Inflammation + - Inflammation, Hyperkeratosis + - Inherited Genetic Syndrome, NOS + - Intestinal Metaplasia + - Iron Overload + - Li-Fraumeni Syndrome + - Low Grade Dysplasia + - Lymphamatoid Papulosis + - Lymphocytic Meningitis + - Lymphocytic Thyroiditis + - Lynch Syndrome + - Malaria + - Metabolic Syndrome + - Mineralcorticoids Excess + - Motor / Movement Change + - Myasthenia Gravis + - Mycobacterium avium Complex + - Myelodysplastic Syndrome + - Neurocystericerosis + - Nodular Prostatic Hyperplasia + - Nonalcoholic Fatty Liver Disease + - Nonalcoholic Steatohepatitis + - None + - Obesity + - Oral Contraceptives + - Pancreatitis + - Parasitic Disease of Biliary Tract + - Pneumocystis Pneumonia + - Pneumonia, NOS + - Polycystic Ovarian Syndrome (PCOS) + - Primary Sclerosing Cholangitis + - Recurrent Pyogenic Cholangitis + - Reflux Disease + - Rheumatoid Arthritis + - Rubella + - Rubinstein-Taybi Syndrome + - Sarcoidosis + - Seizure + - Sensory Changes + - Serous tubal intraepithelial carcinoma (STIC) + - Shingles + - Sialadenitis + - Sjogren's Syndrome + - Skin Rash + - Squamous Metaplasia + - Staphylococcus aureus + - Steatosis + - Succinate Dehydrogenase-Deficient Renal Cell Carcinoma + - Syphilis + - Tattoo + - Thyroid Nodular Hyperplasia + - Tobacco, NOS + - Tobacco, Smokeless + - Tobacco, Smoking + - Treponema pallidum + - Tuberculosis + - Tuberous Sclerosis + - Tubulointerstitial Disease + - Tumor-associated Lymphoid Proliferation + - Turcot Syndrome + - Undescended Testis + - Varicella Zoster Virus + - Vascular Disease + - Vision Changes + - Von Hippel-Lindau Syndrome + - Wagr Syndrome + - Unknown + - Not Reported + enumDef: + Pneumonia, NOS: + $ref: + - "_terms_enum.yaml#/pneumonia_nos/common" + + scan_tracer_used: + $ref: + - "_terms.yaml#/scan_tracer_used/common" + enum: + - Acetate + - Axumin + - Choline + - PSMA + - Sodium Fluoride + - Unknown + - Not Reported + + timepoint_category: + $ref: + - "_terms.yaml#/timepoint_category/common" + enum: + - Adjuvant Therapy + - Adolescence + - Adulthood + - After Chemotherapy + - After Study Enrollment + - Childhood + - End of Consolidation Therapy + - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 + - First Complete Response + - First Treatment + - Follow-up + - Initial Diagnosis + - Last Contact + - Post Adjuvant Therapy + - Post Hormone Therapy + - Post Initial Treatment + - Post Secondary Therapy + - Postoperative + - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy + - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration + - Prior to Treatment + - Progression + - Recurrence + - Recurrence/Progression + - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment + - Within 3 Months of Surgery + - Other + - Unknown + - Not Reported + + treatment_emergent_adverse_event: + $ref: + - "_terms.yaml#/treatment_emergent_adverse_event/common" + enum: + - Definitely + - Possibly + - Probably + - Unlikely + - Unrelated + - Unknown + - Not Reported + + undescended_testis_corrected: + $ref: + - "_terms.yaml#/undescended_testis_corrected/common" + enum: + - "Yes" + - "No" + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_corrected_age: + $ref: + - "_terms.yaml#/undescended_testis_corrected_age/common" + type: integer + maximum: 89 + minimum: 0 + + undescended_testis_corrected_laterality: + $ref: + - "_terms.yaml#/undescended_testis_corrected_laterality/common" + enum: + - Bilateral + - Left + - Right + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_corrected_method: + $ref: + - "_terms.yaml#/undescended_testis_corrected_method/common" + enum: + - Hormones + - Orchiopexy + - Spontaneous Descent + - Testis Removed + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_history: + $ref: + - "_terms.yaml#/undescended_testis_history/common" + enum: + - "Yes" + - "No" + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_history_laterality: + $ref: + - "_terms.yaml#/undescended_testis_history_laterality/common" + enum: + - Bilateral + - Left + - Right + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + viral_hepatitis_serologies: + $ref: + - "_terms.yaml#/viral_hepatitis_serologies/common" + enum: + - HBV Core Antibody + - HBV DNA + - HBV Genotype + - HBV Surface Antibody + - HCV Genotype + - Hepatitis B Surface Antigen + - Hepatitis C Antibody + - Hepatitis C Virus RNA + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + weight: + $ref: + - "_terms.yaml#/weight/common" + type: number + minimum: 0 + + year_of_follow_up: + $ref: + - "_terms.yaml#/year_of_follow_up/common" + type: integer + maximum: 2050 + minimum: 1900 + + cases: + $ref: "_definitions.yaml#/to_one" + + diagnoses: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/gene_expression.yaml b/server/data_files/GDC/model-3.3.0/gene_expression.yaml new file mode 100644 index 0000000..314b4e4 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/gene_expression.yaml @@ -0,0 +1,100 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "gene_expression" +title: Gene Expression +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing gene expression information generated internally by the GDC. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: rna_expression_workflows + backref: gene_expressions + label: data_from + target_type: rna_expression_workflow + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Transcriptome Profiling + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - CSV + - HDF5 + - MEX + - TSV + - TXT + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Exon Expression Quantification + - Gene Expression Quantification + - Isoform Expression Quantification + - Splice Junction Quantification + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Expression Array + - m6A MeRIP-Seq + - RNA-Seq + - scRNA-Seq + - Total RNA-Seq + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Complete Genomics + - GeneChip U133 Plus 2.0 + - GeneChip U133A + - Illumina + - Other + + rna_expression_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/genomic_profile_harmonization_workflow.yaml b/server/data_files/GDC/model-3.3.0/genomic_profile_harmonization_workflow.yaml new file mode 100644 index 0000000..298ae0e --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/genomic_profile_harmonization_workflow.yaml @@ -0,0 +1,61 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "genomic_profile_harmonization_workflow" +title: Genomic Profile Harmonization Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the harmonization of genomic profiling reports. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: submitted_genomic_profiles + backref: genomic_profile_harmonization_workflows + label: performed_on + target_type: submitted_genomic_profile + multiplicity: many_to_one + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - FM Copy Number Variation + - FM Simple Somatic Mutation + - FM Structural Variation + - GENIE Copy Number Variation + - GENIE Simple Somatic Mutation + - GENIE Structural Variation + - MuTect2 + - VCF LiftOver + + submitted_genomic_profiles: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/germline_mutation_calling_workflow.yaml b/server/data_files/GDC/model-3.3.0/germline_mutation_calling_workflow.yaml new file mode 100644 index 0000000..6ce93ad --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/germline_mutation_calling_workflow.yaml @@ -0,0 +1,69 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "germline_mutation_calling_workflow" +title: Germline Mutation Calling Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the germline mutation calling pipeline used to call variants in the + GDC DNA-Seq pipelines. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: true + required: true + subgroup: + - name: aligned_reads_files + backref: germline_mutation_calling_workflows + label: performed_on + target_type: aligned_reads + multiplicity: one_to_many + required: false + - name: submitted_genotyping_arrays + backref: germline_mutation_calling_workflows + label: performed_on + target_type: submitted_genotyping_array + multiplicity: many_to_one + required: false + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - Birdseed + - HaplotypeCaller + - Strelka2 Germline + + aligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + submitted_genotyping_arrays: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/germline_mutation_index.yaml b/server/data_files/GDC/model-3.3.0/germline_mutation_index.yaml new file mode 100644 index 0000000..588f9b5 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/germline_mutation_index.yaml @@ -0,0 +1,79 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "germline_mutation_index" +title: Germline Mutation Index +type: object +namespace: https://gdc.cancer.gov +category: index_file +project: '*' +program: '*' +description: >- + Data file containing the index for germline variation calls. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: simple_germline_variations + backref: germline_mutation_indexes + label: derived_from + target_type: simple_germline_variation + multiplicity: one_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Simple Nucleotide Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TBI + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Germline Mutation Index + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Affymetrix SNP 6.0 + - Illumina + + simple_germline_variations: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/masked_methylation_array.yaml b/server/data_files/GDC/model-3.3.0/masked_methylation_array.yaml new file mode 100644 index 0000000..2f9a760 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/masked_methylation_array.yaml @@ -0,0 +1,118 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "masked_methylation_array" +title: Masked Methylation Array +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing channel data from a methylation array after masking of potential + genotyping information. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: methylation_array_harmonization_workflows + backref: masked_methylation_arrays + label: data_from + target_type: methylation_array_harmonization_workflow + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + - channel + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + channel: + $ref: + - "_terms.yaml#/channel/common" + enum: + - Green + - Red + + chip_id: + $ref: + - "_terms.yaml#/chip_id/common" + type: string + + chip_position: + $ref: + - "_terms.yaml#/chip_position/common" + type: string + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - DNA Methylation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - IDAT + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Masked Intensities + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Methylation Array + + plate_name: + $ref: + - "_terms.yaml#/plate_name/common" + type: string + + plate_well: + $ref: + - "_terms.yaml#/plate_well/common" + type: string + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Illumina Human Methylation 27 + - Illumina Human Methylation 450 + - Illumina Methylation Epic + - Illumina Methylation Epic v2 + + methylation_array_harmonization_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/masked_somatic_mutation.yaml b/server/data_files/GDC/model-3.3.0/masked_somatic_mutation.yaml new file mode 100644 index 0000000..adda431 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/masked_somatic_mutation.yaml @@ -0,0 +1,113 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "masked_somatic_mutation" +title: Masked Somatic Mutation +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + MAF/TSV files that contain a filtered subset of somatic mutations, which may be + open access. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: projects + backref: masked_somatic_mutations + label: derived_from + target_type: project + multiplicity: many_to_one + required: false + - exclusive: true + required: true + subgroup: + - name: genomic_profile_harmonization_workflows + backref: masked_somatic_mutations + label: data_from + target_type: genomic_profile_harmonization_workflow + multiplicity: many_to_many + required: false + - name: somatic_aggregation_workflows + backref: masked_somatic_mutations + label: data_from + target_type: somatic_aggregation_workflow + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Simple Nucleotide Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - MAF + - TSV + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Masked Somatic Mutation + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - miRNA-Seq + - RNA-Seq + - Targeted Sequencing + - WGS + - WXS + + platform: + $ref: + - "read_group.yaml#/properties/platform" + + projects: + $ref: "_definitions.yaml#/to_one_project" + + genomic_profile_harmonization_workflows: + $ref: "_definitions.yaml#/to_many" + + somatic_aggregation_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/metaschema.yaml b/server/data_files/GDC/model-3.3.0/metaschema.yaml new file mode 100644 index 0000000..3d900b4 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/metaschema.yaml @@ -0,0 +1,163 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "metaschema" +title: "GDC JSON schema extension" + +allOf: + - $ref: "http://json-schema.org/draft-04/schema#" + +#GDC extensions +required: + - category #potentially used in submission system, if not may not be needed + - program + - project + - uniqueKeys #for validator to check uniqueness + - links #to specify to the validator what properties are links and their targets + - validators #specify to the validator additional functions to run on the values + - systemProperties #non-user facing values required by backend + - submittable + - downloadable + - previous_version_downloadable + #Require core JSON schema fields here if desired, requiring id + - id + + +definitions: + + link: + type: object + additionalProperties: false + required: + - name + - target_type + - backref + - label + - multiplicity + - required + properties: + name: + type: string + target_type: + type: string + backref: + type: string + label: + type: string + multiplicity: + type: string + enum: + - one_to_one + - one_to_many + - many_to_one + - many_to_many + required: + type: boolean + + link_subgroup: + required: + - exclusive + - required + - subgroup + properties: + exclusive: + type: boolean + required: + type: boolean + subgroup: + type: array + items: + $ref: "#/definitions/link" + + validator_def: + title: "Define a validator to be used on a property" + type: object + required: + - property #the property to be applied to + - function #the function name, predefined somewhere, to use + + properties: + link_to_type: + type: string + + multiplicity: + type: string + enum: + - one_to_one + - one_to_many + - many_to_one + - many_to_many + +properties: + category: + description: "Generalized role that the node has in the commons data model. *_file nodes are reserved for those nodes that have corresponding files in object story." + type: string + enum: + - administrative + - analysis + - biospecimen + - clinical + - data + - data_bundle + - data_file + - index_file + - metadata_file + - notation + - qc_bundle + - TBD + + unique_keys: + description: "Properties or list of properties that can be used to identify this node, and only this node, within the commons." + type: array + items: + type: array + items: + type: string + + submittable: + description: "True/False keyword used to indicate whether this node should be allowed to be user-submitted through normal submission processes." + type: boolean + + downloadable: + description: "Indicates if a file can be downloaded by a user with downloader access." + type: boolean + + previous_version_downloadable: + description: "Indicates if the previous version of a file is available for download." + type: boolean + + validators: + description: "Feature under development to allow cross validation among properties. Not intended to be used in its current form." + type: + - array + - "null" + items: + $ref: "#/definitions/validator_def" + + system_properties: + description: "Properties that will be automatically filled by the system unless otherwise defined by the user." + type: array + + program: + type: string + description: "Denotes the programs within the commons for which this schema may be used." + + project: + type: string + description: "Denotes the projects within the commons for which this schema may be used." + + properties: + type: object + properties: {} + additionalProperties: false + patternProperties: + # Enforce that the property names do not start with numbers, etc + "^[_a-zA-Z][_a-zA-Z0-9]*$": {} + + links: + title: "Define a link to other GDC entities" + description: "Array used to connect two entities within the commons." + type: array + items: + oneOf: + - $ref: "#/definitions/link" + - $ref: "#/definitions/link_subgroup" diff --git a/server/data_files/GDC/model-3.3.0/methylation_array_harmonization_workflow.yaml b/server/data_files/GDC/model-3.3.0/methylation_array_harmonization_workflow.yaml new file mode 100644 index 0000000..c58963b --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/methylation_array_harmonization_workflow.yaml @@ -0,0 +1,54 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "methylation_array_harmonization_workflow" +title: Methylation Array Harmonization Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for workflow used to harmonized methylation arrays. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: raw_methylation_arrays + backref: methylation_array_harmonization_workflows + label: performed_on + target_type: raw_methylation_array + multiplicity: many_to_many + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - SeSAMe Methylation Beta Estimation + + raw_methylation_arrays: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/methylation_beta_value.yaml b/server/data_files/GDC/model-3.3.0/methylation_beta_value.yaml new file mode 100644 index 0000000..7a0e5c4 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/methylation_beta_value.yaml @@ -0,0 +1,101 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "methylation_beta_value" +title: Methylation Beta Value +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing annotated methylation beta values generated by the GDC. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: methylation_array_harmonization_workflows + backref: methylation_beta_values + label: data_from + target_type: methylation_array_harmonization_workflow + multiplicity: many_to_one + required: false + - name: methylation_liftover_workflows + backref: methylation_beta_values + label: data_from + target_type: methylation_liftover_workflow + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - DNA Methylation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TXT + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Methylation Beta Value + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Methylation Array + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Illumina Human Methylation 27 + - Illumina Human Methylation 450 + - Illumina Methylation Epic + - Illumina Methylation Epic v2 + + methylation_array_harmonization_workflows: + $ref: "_definitions.yaml#/to_one" + + methylation_liftover_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/methylation_liftover_workflow.yaml b/server/data_files/GDC/model-3.3.0/methylation_liftover_workflow.yaml new file mode 100644 index 0000000..6cb66f5 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/methylation_liftover_workflow.yaml @@ -0,0 +1,55 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "methylation_liftover_workflow" +title: Methylation Liftover Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the methylation liftover workflow used to harmonize TCGA methylation + data. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: submitted_methylation_beta_values + backref: methylation_liftover_workflows + label: performed_on + target_type: submitted_methylation_beta_value + multiplicity: one_to_one + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - Liftover + + submitted_methylation_beta_values: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/mirna_expression.yaml b/server/data_files/GDC/model-3.3.0/mirna_expression.yaml new file mode 100644 index 0000000..9693a1d --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/mirna_expression.yaml @@ -0,0 +1,87 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "mirna_expression" +title: miRNA Expression +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing miRNA expression information generated internally by the GDC. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: mirna_expression_workflows + backref: mirna_expressions + label: data_from + target_type: mirna_expression_workflow + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Transcriptome Profiling + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - CSV + - TSV + - TXT + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Isoform Expression Quantification + - miRNA Expression Quantification + - Supplementary Files + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - miRNA-Seq + + platform: + $ref: + - "read_group.yaml#/properties/platform" + + mirna_expression_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/mirna_expression_workflow.yaml b/server/data_files/GDC/model-3.3.0/mirna_expression_workflow.yaml new file mode 100644 index 0000000..10e36b1 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/mirna_expression_workflow.yaml @@ -0,0 +1,55 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "mirna_expression_workflow" +title: miRNA Expression Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the miRNA profiling pipeline used to quantify miRNA expression from + GDC harmonized data. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: aligned_reads_files + backref: mirna_expression_workflows + label: performed_on + target_type: aligned_reads + multiplicity: one_to_one + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - BCGSC miRNA Profiling + + aligned_reads_files: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/molecular_test.yaml b/server/data_files/GDC/model-3.3.0/molecular_test.yaml new file mode 100644 index 0000000..63cf143 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/molecular_test.yaml @@ -0,0 +1,7559 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "molecular_test" +title: Molecular Test +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Information pertaining to any molecular tests performed on the patient during a + clinical event. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: false + required: true + subgroup: + - name: follow_ups + backref: molecular_tests + label: performed_at + target_type: follow_up + multiplicity: many_to_one + required: false + - name: slides + backref: molecular_tests + label: related_to + target_type: slide + multiplicity: many_to_one + required: false + - name: diagnoses + backref: molecular_tests + label: related_to + target_type: diagnosis + multiplicity: many_to_one + required: false + +required: + - submitter_id + - gene_symbol + - molecular_analysis_method + - test_result + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + aa_change: + $ref: + - "_terms.yaml#/aa_change/common" + type: string + + aneuploidy: + $ref: + - "_terms.yaml#/aneuploidy/common" + enum: + - Monosomy + - Trisomy + - Unknown + - Not Reported + + antigen: + $ref: + - "_terms.yaml#/antigen/common" + enum: + - BCL6 + - CA19-9 + - CA-125 + - CCND1 + - CD3 + - CD5 + - CD7 + - CD10 + - CD14 + - CD15 + - CD19 + - CD20 + - CD22 + - CD23 + - CD25 + - CD30 + - CD33 + - CD34 + - CD43 + - CD45 + - CD56 + - CD79A + - CD117 + - CD138 + - CEA + - FMC-7 + - HLA-DR + - Immunoglobulin, Cytoplasmic + - Immunoglobulin, Surface + - Kappa, Surface + - Ki67 + - Lambda, Surface + - Mesothelin + - NSE + - Prostate-Specific Antigen (PSA) + - Squamous Cell Carcinoma Antigen (SCCA) + - TAG-72 + - Unknown + - Not Reported + enumDef: + BCL6: + $ref: + - "_terms_enum.yaml#/bcl6/common" + CA19-9: + $ref: + - "_terms_enum.yaml#/ca199/common" + CA-125: + $ref: + - "_terms_enum.yaml#/ca125/common" + CCND1: + $ref: + - "_terms_enum.yaml#/ccnd1/common" + CD3: + $ref: + - "_terms_enum.yaml#/cd3/common" + CD5: + $ref: + - "_terms_enum.yaml#/cd5/common" + CD7: + $ref: + - "_terms_enum.yaml#/cd7/common" + CD10: + $ref: + - "_terms_enum.yaml#/cd10/common" + CD14: + $ref: + - "_terms_enum.yaml#/cd14/common" + CD15: + $ref: + - "_terms_enum.yaml#/cd15/common" + CD19: + $ref: + - "_terms_enum.yaml#/cd19/common" + CD20: + $ref: + - "_terms_enum.yaml#/cd20/common" + CD22: + $ref: + - "_terms_enum.yaml#/cd22/common" + CD23: + $ref: + - "_terms_enum.yaml#/cd23/common" + CD25: + $ref: + - "_terms_enum.yaml#/cd25/common" + CD30: + $ref: + - "_terms_enum.yaml#/cd30/common" + CD33: + $ref: + - "_terms_enum.yaml#/cd33/common" + CD34: + $ref: + - "_terms_enum.yaml#/cd34/common" + CD43: + $ref: + - "_terms_enum.yaml#/cd43/common" + CD45: + $ref: + - "_terms_enum.yaml#/cd45/common" + CD56: + $ref: + - "_terms_enum.yaml#/cd56/common" + CD79A: + $ref: + - "_terms_enum.yaml#/cd79a/common" + CD117: + $ref: + - "_terms_enum.yaml#/cd117/common" + CD138: + $ref: + - "_terms_enum.yaml#/cd138/common" + CEA: + $ref: + - "_terms_enum.yaml#/cea/common" + HLA-DR: + $ref: + - "_terms_enum.yaml#/hladr/common" + Mesothelin: + $ref: + - "_terms_enum.yaml#/mesothelin/common" + NSE: + $ref: + - "_terms_enum.yaml#/nse/common" + Prostate-Specific Antigen (PSA): + $ref: + - "_terms_enum.yaml#/prostatespecific_antigen_psa/common" + Squamous Cell Carcinoma Antigen (SCCA): + $ref: + - "_terms_enum.yaml#/squamous_cell_carcinoma_antigen_scca/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + biospecimen_type: + $ref: + - "_terms.yaml#/biospecimen_type/common" + enum: + - Blood + - Bone Marrow + - Buccal Mucosa + - Buffy Coat + - Cerebrospinal Fluid + - Connective Tissue + - Embryonic Fluid + - Embryonic Tissue + - Feces + - Granulocyte + - Involved Tissue, NOS + - Muscle Tissue + - Nerve Tissue + - Peritoneal Fluid + - Plasma + - Pleural Fluid + - Saliva + - Serum + - Skin + - Soft Tissue + - Tissue, NOS + - Uninvolved Tissue, NOS + - Urine + - Unknown + - Not Reported + enumDef: + Bone Marrow: + $ref: + - "_terms_enum.yaml#/bone_marrow/common" + Buccal Mucosa: + $ref: + - "_terms_enum.yaml#/buccal_mucosa/common" + Buffy Coat: + $ref: + - "_terms_enum.yaml#/buffy_coat/common" + Cerebrospinal Fluid: + $ref: + - "_terms_enum.yaml#/cerebrospinal_fluid/common" + Connective Tissue: + $ref: + - "_terms_enum.yaml#/connective_tissue/common" + Embryonic Fluid: + $ref: + - "_terms_enum.yaml#/embryonic_fluid/common" + Embryonic Tissue: + $ref: + - "_terms_enum.yaml#/embryonic_tissue/common" + Feces: + $ref: + - "_terms_enum.yaml#/feces/common" + Granulocyte: + $ref: + - "_terms_enum.yaml#/granulocyte/common" + Muscle Tissue: + $ref: + - "_terms_enum.yaml#/muscle_tissue/common" + Nerve Tissue: + $ref: + - "_terms_enum.yaml#/nerve_tissue/common" + Peritoneal Fluid: + $ref: + - "_terms_enum.yaml#/peritoneal_fluid/common" + Plasma: + $ref: + - "_terms_enum.yaml#/plasma/common" + Pleural Fluid: + $ref: + - "_terms_enum.yaml#/pleural_fluid/common" + Saliva: + $ref: + - "_terms_enum.yaml#/saliva/common" + Serum: + $ref: + - "_terms_enum.yaml#/serum/common" + Soft Tissue: + $ref: + - "_terms_enum.yaml#/soft_tissue/common" + Tissue, NOS: + $ref: + - "_terms_enum.yaml#/tissue_nos/common" + Urine: + $ref: + - "_terms_enum.yaml#/urine/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + biospecimen_volume: + $ref: + - "_terms.yaml#/biospecimen_volume/common" + type: number + minimum: 0 + + blood_test_normal_range_lower: + $ref: + - "_terms.yaml#/blood_test_normal_range_lower/common" + type: number + + blood_test_normal_range_upper: + $ref: + - "_terms.yaml#/blood_test_normal_range_upper/common" + type: number + + cell_count: + $ref: + - "_terms.yaml#/cell_count/common" + type: integer + minimum: 0 + + chromosomal_translocation: + $ref: + - "_terms.yaml#/chromosomal_translocation/common" + enum: + - t(3;5)(q25;q34) + - t(4;11) + - t(6;9) + - t(6;11)(q27;q23) + - t(8;21) + - t(9;11) + - t(9;11)(p22;q23) + - t(9;22) + - t(10;11)(p11.2;q23) + - t(11;19)(q23;p13.1) + - t(15;17) + - Unknown + - Not Reported + + chromosome: + $ref: + - "_terms.yaml#/chromosome/common" + enum: + - chr1 + - chr2 + - chr3 + - chr4 + - chr5 + - chr6 + - chr7 + - chr8 + - chr9 + - chr10 + - chr11 + - chr12 + - chr13 + - chr14 + - chr15 + - chr16 + - chr17 + - chr18 + - chr19 + - chr20 + - chr21 + - chr22 + - chr23 + - chrM + - chrX + - chrY + - Unknown + - Not Reported + enumDef: + chr1: + $ref: + - "_terms_enum.yaml#/chr1/common" + chr2: + $ref: + - "_terms_enum.yaml#/chr2/common" + chr3: + $ref: + - "_terms_enum.yaml#/chr3/common" + chr4: + $ref: + - "_terms_enum.yaml#/chr4/common" + chr5: + $ref: + - "_terms_enum.yaml#/chr5/common" + chr6: + $ref: + - "_terms_enum.yaml#/chr6/common" + chr7: + $ref: + - "_terms_enum.yaml#/chr7/common" + chr8: + $ref: + - "_terms_enum.yaml#/chr8/common" + chr9: + $ref: + - "_terms_enum.yaml#/chr9/common" + chr10: + $ref: + - "_terms_enum.yaml#/chr10/common" + chr11: + $ref: + - "_terms_enum.yaml#/chr11/common" + chr12: + $ref: + - "_terms_enum.yaml#/chr12/common" + chr13: + $ref: + - "_terms_enum.yaml#/chr13/common" + chr14: + $ref: + - "_terms_enum.yaml#/chr14/common" + chr15: + $ref: + - "_terms_enum.yaml#/chr15/common" + chr16: + $ref: + - "_terms_enum.yaml#/chr16/common" + chr17: + $ref: + - "_terms_enum.yaml#/chr17/common" + chr18: + $ref: + - "_terms_enum.yaml#/chr18/common" + chr19: + $ref: + - "_terms_enum.yaml#/chr19/common" + chr20: + $ref: + - "_terms_enum.yaml#/chr20/common" + chr21: + $ref: + - "_terms_enum.yaml#/chr21/common" + chr22: + $ref: + - "_terms_enum.yaml#/chr22/common" + chr23: + $ref: + - "_terms_enum.yaml#/chr23/common" + chrM: + $ref: + - "_terms_enum.yaml#/chrm/common" + chrX: + $ref: + - "_terms_enum.yaml#/chrx/common" + chrY: + $ref: + - "_terms_enum.yaml#/chry/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + chromosome_arm: + $ref: + - "_terms.yaml#/chromosome_arm/common" + enum: + - p + - q + - Unknown + - Not Reported + + clonality: + $ref: + - "_terms.yaml#/clonality/common" + enum: + - Clonal + - Non-clonal + - Unknown + - Not Reported + enumDef: + Clonal: + $ref: + - "_terms_enum.yaml#/clonal/common" + Non-clonal: + $ref: + - "_terms_enum.yaml#/nonclonal/common" + + copy_number: + $ref: + - "_terms.yaml#/copy_number/common" + type: number + minimum: 0 + + cytoband: + $ref: + - "_terms.yaml#/cytoband/common" + type: string + + days_to_test: + $ref: + - "_terms.yaml#/days_to_test/common" + type: integer + maximum: 32872 + minimum: -32872 + + exon: + $ref: + - "_terms.yaml#/exon/common" + type: string + pattern: "^(0|[1-9][0-9]{0,3})[a-z]?$" + + gene_symbol: + $ref: + - "_terms.yaml#/gene_symbol/common" + enum: + - A1CF + - ABI1 + - ABL1 + - ABL2 + - ACACA + - ACKR3 + - ACSL3 + - ACSL6 + - ACVR1 + - ACVR2A + - AFF1 + - AFF3 + - AFF4 + - AKAP9 + - AKT1 + - AKT2 + - AKT3 + - ALDH2 + - ALK + - AMER1 + - ANK1 + - APC + - APOBEC3B + - AQP1 + - AR + - ARAF + - ARHGAP5 + - ARHGAP26 + - ARHGEF12 + - ARID1A + - ARID1B + - ARID2 + - ARNT + - ASPSCR1 + - ASXL1 + - ASXL2 + - ATF1 + - ATIC + - ATM + - ATP1A1 + - ATP2B3 + - ATR + - ATRX + - AXIN1 + - AXIN2 + - B2M + - BAP1 + - BARD1 + - BCL2 + - BCL2L12 + - BCL3 + - BCL6 + - BCL7A + - BCL9 + - BCL9L + - BCL10 + - BCL11A + - BCL11B + - BCLAF1 + - BCOR + - BCORL1 + - BCR + - BIRC3 + - BIRC6 + - BLM + - BMP5 + - BMPR1A + - BRAF + - BRCA1 + - BRCA2 + - BRD1 + - BRD3 + - BRD4 + - BRIP1 + - BTBD18 + - BTG1 + - BTK + - BUB1B + - C15orf65 + - CACNA1D + - CALB2 + - CALR + - CAMTA1 + - CANT1 + - CARD11 + - CARS + - CASP8 + - CBFA2T2 + - CBFA2T3 + - CBFB + - CBL + - CBLB + - CBLC + - CCDC6 + - CCNB1IP1 + - CCNC + - CCND1 + - CCND2 + - CCND3 + - CCNE1 + - CCR4 + - CCR7 + - CD28 + - CD74 + - CD79A + - CD79B + - CD99 + - CD209 + - CD274 + - CDC73 + - CDH1 + - CDH10 + - CDH11 + - CDH17 + - CDK4 + - CDK6 + - CDK12 + - CDKN1A + - CDKN1B + - CDKN2A + - CDKN2C + - CDX2 + - CEBPA + - CEP89 + - CEP164 + - CEP170B + - CHCHD7 + - CHD2 + - CHD4 + - CHEK2 + - CHGA + - CHIC2 + - CHST11 + - CIC + - CIITA + - CLIP1 + - CLP1 + - CLTC + - CLTCL1 + - CNBD1 + - CNBP + - CNOT3 + - CNTNAP2 + - CNTRL + - COL1A1 + - COL2A1 + - COL3A1 + - COX6C + - CREB1 + - CREB3L1 + - CREB3L2 + - CREBBP + - CRLF2 + - CRNKL1 + - CRTC1 + - CRTC3 + - CSF1R + - CSF3R + - CSMD3 + - CTCF + - CTDP1 + - CTNNA2 + - CTNNB1 + - CTNND1 + - CTNND2 + - CUL3 + - CUX1 + - CXCR4 + - CYLD + - CYP2C8 + - CYSLTR2 + - DAXX + - DCAF12L2 + - DCC + - DCTN1 + - DDB2 + - DDIT3 + - DDR2 + - DDX3X + - DDX5 + - DDX6 + - DDX10 + - DEK + - DGCR8 + - DICER1 + - DNAJB1 + - DNM2 + - DNMT3A + - DNTT + - DOT1L + - DROSHA + - DUX4L1 + - EBF1 + - ECT2L + - EED + - EGFR + - EIF1AX + - EIF3E + - EIF4A2 + - ELF3 + - ELF4 + - ELK4 + - ELL + - ELN + - EML4 + - EP300 + - EPAS1 + - EPCAM + - EPHA3 + - EPHA7 + - EPS15 + - ERBB2 + - ERBB3 + - ERBB4 + - ERC1 + - ERCC2 + - ERCC3 + - ERCC4 + - ERCC5 + - ERG + - ESR1 + - ETNK1 + - ETV1 + - ETV4 + - ETV5 + - ETV6 + - EWSR1 + - EXT1 + - EXT2 + - EZH2 + - EZR + - FAM46C + - FAM47C + - FAM131B + - FAM135B + - FANCA + - FANCC + - FANCD2 + - FANCE + - FANCF + - FANCG + - FAS + - FAT1 + - FAT3 + - FAT4 + - FBLN2 + - FBXO11 + - FBXW7 + - FCGR2B + - FCRL4 + - FEN1 + - FES + - FEV + - FGFR1 + - FGFR1OP + - FGFR2 + - FGFR3 + - FGFR4 + - FH + - FHIT + - FIP1L1 + - FKBP9 + - FLCN + - FLI1 + - FLNA + - FLT3 + - FLT4 + - FNBP1 + - FOXA1 + - FOXL2 + - FOXO1 + - FOXO3 + - FOXO4 + - FOXP1 + - FOXR1 + - FRYL + - FSTL3 + - FUBP1 + - FUS + - GAS7 + - GATA1 + - GATA2 + - GATA3 + - GCET1 + - GLI1 + - GLIS2 + - GMPS + - GNA11 + - GNAQ + - GNAS + - GOLGA5 + - GOPC + - GPC3 + - GPHN + - GRIN2A + - GRM3 + - H3F3A + - H3F3B + - HERPUD1 + - HEY1 + - HIF1A + - HIP1 + - HIST1H3B + - HIST1H4I + - HLA-A + - HLF + - HMGA1 + - HMGA2 + - HMGB3 + - HMGN2P46 + - HNF1A + - HNRNPA2B1 + - HNRNPH1 + - HOOK3 + - HOXA9 + - HOXA11 + - HOXA13 + - HOXB1 + - HOXC11 + - HOXC13 + - HOXD11 + - HOXD13 + - HRAS + - HSP90AA1 + - HSP90AB1 + - ID3 + - IDH1 + - IDH2 + - IGH + - IGK + - IGKC + - IGL + - IKBKB + - IKZF1 + - IL2 + - IL6ST + - IL7R + - IL21R + - INO80D + - IRF4 + - IRS4 + - ISX + - ITGAV + - ITK + - JAK1 + - JAK2 + - JAK3 + - JARID2 + - JAZF1 + - JUN + - KAT6A + - KAT6B + - KAT7 + - KCNJ5 + - KDM5A + - KDM5C + - KDM6A + - KDR + - KDSR + - KEAP1 + - KIAA1549 + - KIF5B + - KIT + - KLF4 + - KLF6 + - KLK2 + - KMT2A + - KMT2C + - KMT2D + - KNL1 + - KNSTRN + - KRAS + - KRT7 + - KRT20 + - KTN1 + - LARP4B + - LASP1 + - LCK + - LCP1 + - LEF1 + - LHFP + - LIFR + - LMNA + - LMO1 + - LMO2 + - LPP + - LRIG3 + - LRP1B + - LSM14A + - LYL1 + - LZTR1 + - MAF + - MAFB + - MALAT1 + - MALT1 + - MAML2 + - MAML3 + - MAP2K1 + - MAP2K2 + - MAP2K4 + - MAP3K1 + - MAP3K13 + - MAPK1 + - MAX + - MB21D2 + - MDM2 + - MDM4 + - MDS2 + - MECOM + - MED12 + - MEN1 + - MET + - MGMT + - MIB1 + - MITF + - MKL1 + - MLF1 + - MLH1 + - MLH2 + - MLLT1 + - MLLT3 + - MLLT4 + - MLLT6 + - MLLT10 + - MLLT11 + - MN1 + - MNX1 + - MPL + - MPO + - MSH2 + - MSH6 + - MSI2 + - MSN + - MTCP1 + - MTOR + - MUC1 + - MUC4 + - MUC16 + - MUTYH + - MYB + - MYC + - MYCL + - MYCN + - MYD88 + - MYH9 + - MYH11 + - MYO5A + - MYOD1 + - NAB2 + - NACA + - NBEA + - NBN + - NCKIPSD + - NCOA1 + - NCOA2 + - NCOA4 + - NCOR1 + - NCOR2 + - NDRG1 + - NF1 + - NF2 + - NFATC2 + - NFE2L2 + - NFIB + - NFKB2 + - NFKBIE + - NIN + - NKX2-1 + - NONO + - NOTCH1 + - NOTCH2 + - NPM1 + - NR4A3 + - NRAS + - NRG1 + - NSD1 + - NSD2 + - NSD3 + - NT5C2 + - NTHL1 + - NTRK1 + - NTRK3 + - NUMA1 + - NUP98 + - NUP214 + - NUTM1 + - NUTM2A + - NUTM2B + - OLIG2 + - OMD + - P2RY8 + - PABPC1 + - PAFAH1B2 + - PALB2 + - PATZ1 + - PAX3 + - PAX5 + - PAX7 + - PAX8 + - PBRM1 + - PBX1 + - PCBP1 + - PCM1 + - PDCD1LG2 + - PDE4DIP + - PDGFB + - PDGFRA + - PDGFRB + - PDPN + - PER1 + - PGR + - PHF6 + - PHF23 + - PHOX2B + - PICALM + - PIK3CA + - PIK3CB + - PIK3R1 + - PIM1 + - PIM3 + - PLAG1 + - PLCG1 + - PML + - PMS1 + - PMS2 + - POLD1 + - POLE + - POLG + - POLQ + - POT1 + - POU2AF1 + - POU5F1 + - PPARG + - PPFIBP1 + - PPM1D + - PPP2R1A + - PPP6C + - PRCC + - PRDM1 + - PRDM2 + - PRDM16 + - PREX2 + - PRF1 + - PRKACA + - PRKAR1A + - PRKCB + - PRPF40B + - PRRX1 + - PSIP1 + - PTCH1 + - PTEN + - PTGS2 + - PTK6 + - PTP4A1 + - PTPN6 + - PTPN11 + - PTPN13 + - PTPRB + - PTPRC + - PTPRK + - PTPRT + - PWWP2A + - QKI + - RABEP1 + - RAC1 + - RAD21 + - RAD51B + - RAF1 + - RALGDS + - RANBP2 + - RAP1GDS1 + - RARA + - RAS, NOS + - RB1 + - RBM10 + - RBM15 + - RECQL4 + - REL + - RET + - RGPD3 + - RGS7 + - RHOA + - RHOH + - RMI2 + - RNF43 + - RNF213 + - ROBO2 + - ROS1 + - RPL5 + - RPL10 + - RPL22 + - RPN1 + - RPS15 + - RSPO2 + - RSPO3 + - RUNX1 + - RUNX1T1 + - S100A7 + - SALL4 + - SBDS + - SDC4 + - SDHA + - SDHAF2 + - SDHB + - SDHC + - SDHD + - SEPT5 + - SEPT6 + - SEPT9 + - SET + - SETBP1 + - SETD1A + - SETD2 + - SF3B1 + - SFPQ + - SFRP4 + - SGK1 + - SH2B3 + - SH3GL1 + - SHTN1 + - SIRPA + - SKI + - SLC34A2 + - SLC45A3 + - SLC66A2 (aka PQLC1) + - SMAD2 + - SMAD3 + - SMAD4 + - SMARCA4 + - SMARCB1 + - SMARCD1 + - SMARCE1 + - SMC1A + - SMO + - SND1 + - SNX29 + - SOCS1 + - SOX2 + - SPECC1 + - SPEN + - SPOP + - SRC + - SRGAP3 + - SRSF2 + - SRSF3 + - SS18 + - SS18L1 + - SSX1 + - SSX2 + - SSX4 + - STAG1 + - STAG2 + - STAT3 + - STAT5B + - STAT6 + - STIL + - STK11 + - STRN + - SUFU + - SUZ12 + - SYK + - SYP + - TAF15 + - TAL1 + - TAL2 + - TBL1XR1 + - TBX3 + - TCEA1 + - TCF3 + - TCF7L2 + - TCF12 + - TCL1A + - TEC + - TERT + - TET1 + - TET2 + - TFE3 + - TFEB + - TFG + - TFPT + - TFRC + - TGFBR2 + - THRAP3 + - TLR2 + - TLX1 + - TLX3 + - TMEM127 + - TMPRSS2 + - TNC + - TNFAIP3 + - TNFRSF14 + - TNFRSF17 + - TOP1 + - TOP2B + - TP53 + - TP63 + - TPM3 + - TPM4 + - TPR + - TRA + - TRAF7 + - TRB + - TRD + - TRIM24 + - TRIM27 + - TRIM33 + - TRIP11 + - TRRAP + - TSC1 + - TSC2 + - TSHR + - U2AF1 + - UBB + - UBR5 + - USP6 + - USP8 + - VAV1 + - VHL + - VTI1A + - WAS + - WDCP + - WIF1 + - WNK2 + - WRN + - WT1 + - WWTR1 + - XPA + - XPC + - XPO1 + - YWHAE + - ZBTB16 + - ZCCHC8 + - ZEB1 + - ZEB2 + - ZFHX3 + - ZMYM3 + - ZNF198 + - ZNF331 + - ZNF384 + - ZNF429 + - ZNF444 + - ZNF479 + - ZNF521 + - ZNRF3 + - ZRSR2 + - Unknown + - Not Reported + - Not Applicable + enumDef: + A1CF: + $ref: + - "_terms_enum.yaml#/a1cf/common" + ABI1: + $ref: + - "_terms_enum.yaml#/abi1/common" + ABL1: + $ref: + - "_terms_enum.yaml#/abl1/common" + ABL2: + $ref: + - "_terms_enum.yaml#/abl2/common" + ACACA: + $ref: + - "_terms_enum.yaml#/acaca/common" + ACKR3: + $ref: + - "_terms_enum.yaml#/ackr3/common" + ACSL3: + $ref: + - "_terms_enum.yaml#/acsl3/common" + ACSL6: + $ref: + - "_terms_enum.yaml#/acsl6/common" + ACVR1: + $ref: + - "_terms_enum.yaml#/acvr1/common" + ACVR2A: + $ref: + - "_terms_enum.yaml#/acvr2a/common" + AFF1: + $ref: + - "_terms_enum.yaml#/aff1/common" + AFF3: + $ref: + - "_terms_enum.yaml#/aff3/common" + AFF4: + $ref: + - "_terms_enum.yaml#/aff4/common" + AKAP9: + $ref: + - "_terms_enum.yaml#/akap9/common" + AKT1: + $ref: + - "_terms_enum.yaml#/akt1/common" + AKT2: + $ref: + - "_terms_enum.yaml#/akt2/common" + AKT3: + $ref: + - "_terms_enum.yaml#/akt3/common" + ALDH2: + $ref: + - "_terms_enum.yaml#/aldh2/common" + ALK: + $ref: + - "_terms_enum.yaml#/alk/common" + AMER1: + $ref: + - "_terms_enum.yaml#/amer1/common" + ANK1: + $ref: + - "_terms_enum.yaml#/ank1/common" + APC: + $ref: + - "_terms_enum.yaml#/apc/common" + APOBEC3B: + $ref: + - "_terms_enum.yaml#/apobec3b/common" + AR: + $ref: + - "_terms_enum.yaml#/ar/common" + ARAF: + $ref: + - "_terms_enum.yaml#/araf/common" + ARHGAP5: + $ref: + - "_terms_enum.yaml#/arhgap5/common" + ARHGAP26: + $ref: + - "_terms_enum.yaml#/arhgap26/common" + ARHGEF12: + $ref: + - "_terms_enum.yaml#/arhgef12/common" + ARID1A: + $ref: + - "_terms_enum.yaml#/arid1a/common" + ARID1B: + $ref: + - "_terms_enum.yaml#/arid1b/common" + ARID2: + $ref: + - "_terms_enum.yaml#/arid2/common" + ARNT: + $ref: + - "_terms_enum.yaml#/arnt/common" + ASPSCR1: + $ref: + - "_terms_enum.yaml#/aspscr1/common" + ASXL1: + $ref: + - "_terms_enum.yaml#/asxl1/common" + ASXL2: + $ref: + - "_terms_enum.yaml#/asxl2/common" + ATF1: + $ref: + - "_terms_enum.yaml#/atf1/common" + ATIC: + $ref: + - "_terms_enum.yaml#/atic/common" + ATM: + $ref: + - "_terms_enum.yaml#/atm/common" + ATP1A1: + $ref: + - "_terms_enum.yaml#/atp1a1/common" + ATP2B3: + $ref: + - "_terms_enum.yaml#/atp2b3/common" + ATR: + $ref: + - "_terms_enum.yaml#/atr/common" + ATRX: + $ref: + - "_terms_enum.yaml#/atrx/common" + AXIN1: + $ref: + - "_terms_enum.yaml#/axin1/common" + AXIN2: + $ref: + - "_terms_enum.yaml#/axin2/common" + B2M: + $ref: + - "_terms_enum.yaml#/b2m/common" + BAP1: + $ref: + - "_terms_enum.yaml#/bap1/common" + BARD1: + $ref: + - "_terms_enum.yaml#/bard1/common" + BCL2: + $ref: + - "_terms_enum.yaml#/bcl2/common" + BCL2L12: + $ref: + - "_terms_enum.yaml#/bcl2l12/common" + BCL3: + $ref: + - "_terms_enum.yaml#/bcl3/common" + BCL6: + $ref: + - "_terms_enum.yaml#/bcl6/common" + BCL7A: + $ref: + - "_terms_enum.yaml#/bcl7a/common" + BCL9: + $ref: + - "_terms_enum.yaml#/bcl9/common" + BCL9L: + $ref: + - "_terms_enum.yaml#/bcl9l/common" + BCL10: + $ref: + - "_terms_enum.yaml#/bcl10/common" + BCL11A: + $ref: + - "_terms_enum.yaml#/bcl11a/common" + BCL11B: + $ref: + - "_terms_enum.yaml#/bcl11b/common" + BCLAF1: + $ref: + - "_terms_enum.yaml#/bclaf1/common" + BCOR: + $ref: + - "_terms_enum.yaml#/bcor/common" + BCORL1: + $ref: + - "_terms_enum.yaml#/bcorl1/common" + BCR: + $ref: + - "_terms_enum.yaml#/bcr/common" + BIRC3: + $ref: + - "_terms_enum.yaml#/birc3/common" + BIRC6: + $ref: + - "_terms_enum.yaml#/birc6/common" + BLM: + $ref: + - "_terms_enum.yaml#/blm/common" + BMP5: + $ref: + - "_terms_enum.yaml#/bmp5/common" + BMPR1A: + $ref: + - "_terms_enum.yaml#/bmpr1a/common" + BRAF: + $ref: + - "_terms_enum.yaml#/braf/common" + BRCA1: + $ref: + - "_terms_enum.yaml#/brca1/common" + BRCA2: + $ref: + - "_terms_enum.yaml#/brca2/common" + BRD1: + $ref: + - "_terms_enum.yaml#/brd1/common" + BRD3: + $ref: + - "_terms_enum.yaml#/brd3/common" + BRD4: + $ref: + - "_terms_enum.yaml#/brd4/common" + BRIP1: + $ref: + - "_terms_enum.yaml#/brip1/common" + BTBD18: + $ref: + - "_terms_enum.yaml#/btbd18/common" + BTG1: + $ref: + - "_terms_enum.yaml#/btg1/common" + BTK: + $ref: + - "_terms_enum.yaml#/btk/common" + BUB1B: + $ref: + - "_terms_enum.yaml#/bub1b/common" + C15orf65: + $ref: + - "_terms_enum.yaml#/c15orf65/common" + CACNA1D: + $ref: + - "_terms_enum.yaml#/cacna1d/common" + CALR: + $ref: + - "_terms_enum.yaml#/calr/common" + CAMTA1: + $ref: + - "_terms_enum.yaml#/camta1/common" + CANT1: + $ref: + - "_terms_enum.yaml#/cant1/common" + CARD11: + $ref: + - "_terms_enum.yaml#/card11/common" + CARS: + $ref: + - "_terms_enum.yaml#/cars/common" + CASP8: + $ref: + - "_terms_enum.yaml#/casp8/common" + CBFA2T2: + $ref: + - "_terms_enum.yaml#/cbfa2t2/common" + CBFA2T3: + $ref: + - "_terms_enum.yaml#/cbfa2t3/common" + CBFB: + $ref: + - "_terms_enum.yaml#/cbfb/common" + CBL: + $ref: + - "_terms_enum.yaml#/cbl/common" + CBLB: + $ref: + - "_terms_enum.yaml#/cblb/common" + CBLC: + $ref: + - "_terms_enum.yaml#/cblc/common" + CCDC6: + $ref: + - "_terms_enum.yaml#/ccdc6/common" + CCNB1IP1: + $ref: + - "_terms_enum.yaml#/ccnb1ip1/common" + CCNC: + $ref: + - "_terms_enum.yaml#/ccnc/common" + CCND1: + $ref: + - "_terms_enum.yaml#/ccnd1/common" + CCND2: + $ref: + - "_terms_enum.yaml#/ccnd2/common" + CCND3: + $ref: + - "_terms_enum.yaml#/ccnd3/common" + CCNE1: + $ref: + - "_terms_enum.yaml#/ccne1/common" + CCR4: + $ref: + - "_terms_enum.yaml#/ccr4/common" + CCR7: + $ref: + - "_terms_enum.yaml#/ccr7/common" + CD28: + $ref: + - "_terms_enum.yaml#/cd28/common" + CD74: + $ref: + - "_terms_enum.yaml#/cd74/common" + CD79A: + $ref: + - "_terms_enum.yaml#/cd79a/common" + CD79B: + $ref: + - "_terms_enum.yaml#/cd79b/common" + CD99: + $ref: + - "_terms_enum.yaml#/cd99/common" + CD209: + $ref: + - "_terms_enum.yaml#/cd209/common" + CD274: + $ref: + - "_terms_enum.yaml#/cd274/common" + CDC73: + $ref: + - "_terms_enum.yaml#/cdc73/common" + CDH1: + $ref: + - "_terms_enum.yaml#/cdh1/common" + CDH10: + $ref: + - "_terms_enum.yaml#/cdh10/common" + CDH11: + $ref: + - "_terms_enum.yaml#/cdh11/common" + CDH17: + $ref: + - "_terms_enum.yaml#/cdh17/common" + CDK4: + $ref: + - "_terms_enum.yaml#/cdk4/common" + CDK6: + $ref: + - "_terms_enum.yaml#/cdk6/common" + CDK12: + $ref: + - "_terms_enum.yaml#/cdk12/common" + CDKN1A: + $ref: + - "_terms_enum.yaml#/cdkn1a/common" + CDKN1B: + $ref: + - "_terms_enum.yaml#/cdkn1b/common" + CDKN2A: + $ref: + - "_terms_enum.yaml#/cdkn2a/common" + CDKN2C: + $ref: + - "_terms_enum.yaml#/cdkn2c/common" + CDX2: + $ref: + - "_terms_enum.yaml#/cdx2/common" + CEBPA: + $ref: + - "_terms_enum.yaml#/cebpa/common" + CEP89: + $ref: + - "_terms_enum.yaml#/cep89/common" + CEP170B: + $ref: + - "_terms_enum.yaml#/cep170b/common" + CHCHD7: + $ref: + - "_terms_enum.yaml#/chchd7/common" + CHD2: + $ref: + - "_terms_enum.yaml#/chd2/common" + CHD4: + $ref: + - "_terms_enum.yaml#/chd4/common" + CHEK2: + $ref: + - "_terms_enum.yaml#/chek2/common" + CHGA: + $ref: + - "_terms_enum.yaml#/chga/common" + CHIC2: + $ref: + - "_terms_enum.yaml#/chic2/common" + CHST11: + $ref: + - "_terms_enum.yaml#/chst11/common" + CIC: + $ref: + - "_terms_enum.yaml#/cic/common" + CIITA: + $ref: + - "_terms_enum.yaml#/ciita/common" + CLIP1: + $ref: + - "_terms_enum.yaml#/clip1/common" + CLP1: + $ref: + - "_terms_enum.yaml#/clp1/common" + CLTC: + $ref: + - "_terms_enum.yaml#/cltc/common" + CLTCL1: + $ref: + - "_terms_enum.yaml#/cltcl1/common" + CNBD1: + $ref: + - "_terms_enum.yaml#/cnbd1/common" + CNBP: + $ref: + - "_terms_enum.yaml#/cnbp/common" + CNOT3: + $ref: + - "_terms_enum.yaml#/cnot3/common" + CNTNAP2: + $ref: + - "_terms_enum.yaml#/cntnap2/common" + CNTRL: + $ref: + - "_terms_enum.yaml#/cntrl/common" + COL1A1: + $ref: + - "_terms_enum.yaml#/col1a1/common" + COL2A1: + $ref: + - "_terms_enum.yaml#/col2a1/common" + COL3A1: + $ref: + - "_terms_enum.yaml#/col3a1/common" + COX6C: + $ref: + - "_terms_enum.yaml#/cox6c/common" + CREB1: + $ref: + - "_terms_enum.yaml#/creb1/common" + CREB3L1: + $ref: + - "_terms_enum.yaml#/creb3l1/common" + CREB3L2: + $ref: + - "_terms_enum.yaml#/creb3l2/common" + CREBBP: + $ref: + - "_terms_enum.yaml#/crebbp/common" + CRLF2: + $ref: + - "_terms_enum.yaml#/crlf2/common" + CRNKL1: + $ref: + - "_terms_enum.yaml#/crnkl1/common" + CRTC1: + $ref: + - "_terms_enum.yaml#/crtc1/common" + CRTC3: + $ref: + - "_terms_enum.yaml#/crtc3/common" + CSF1R: + $ref: + - "_terms_enum.yaml#/csf1r/common" + CSF3R: + $ref: + - "_terms_enum.yaml#/csf3r/common" + CSMD3: + $ref: + - "_terms_enum.yaml#/csmd3/common" + CTCF: + $ref: + - "_terms_enum.yaml#/ctcf/common" + CTNNA2: + $ref: + - "_terms_enum.yaml#/ctnna2/common" + CTNNB1: + $ref: + - "_terms_enum.yaml#/ctnnb1/common" + CTNND1: + $ref: + - "_terms_enum.yaml#/ctnnd1/common" + CTNND2: + $ref: + - "_terms_enum.yaml#/ctnnd2/common" + CUL3: + $ref: + - "_terms_enum.yaml#/cul3/common" + CUX1: + $ref: + - "_terms_enum.yaml#/cux1/common" + CXCR4: + $ref: + - "_terms_enum.yaml#/cxcr4/common" + CYLD: + $ref: + - "_terms_enum.yaml#/cyld/common" + CYP2C8: + $ref: + - "_terms_enum.yaml#/cyp2c8/common" + CYSLTR2: + $ref: + - "_terms_enum.yaml#/cysltr2/common" + DAXX: + $ref: + - "_terms_enum.yaml#/daxx/common" + DCAF12L2: + $ref: + - "_terms_enum.yaml#/dcaf12l2/common" + DCC: + $ref: + - "_terms_enum.yaml#/dcc/common" + DCTN1: + $ref: + - "_terms_enum.yaml#/dctn1/common" + DDB2: + $ref: + - "_terms_enum.yaml#/ddb2/common" + DDIT3: + $ref: + - "_terms_enum.yaml#/ddit3/common" + DDR2: + $ref: + - "_terms_enum.yaml#/ddr2/common" + DDX3X: + $ref: + - "_terms_enum.yaml#/ddx3x/common" + DDX5: + $ref: + - "_terms_enum.yaml#/ddx5/common" + DDX6: + $ref: + - "_terms_enum.yaml#/ddx6/common" + DDX10: + $ref: + - "_terms_enum.yaml#/ddx10/common" + DEK: + $ref: + - "_terms_enum.yaml#/dek/common" + DGCR8: + $ref: + - "_terms_enum.yaml#/dgcr8/common" + DICER1: + $ref: + - "_terms_enum.yaml#/dicer1/common" + DNAJB1: + $ref: + - "_terms_enum.yaml#/dnajb1/common" + DNM2: + $ref: + - "_terms_enum.yaml#/dnm2/common" + DNMT3A: + $ref: + - "_terms_enum.yaml#/dnmt3a/common" + DOT1L: + $ref: + - "_terms_enum.yaml#/dot1l/common" + DROSHA: + $ref: + - "_terms_enum.yaml#/drosha/common" + DUX4L1: + $ref: + - "_terms_enum.yaml#/dux4l1/common" + EBF1: + $ref: + - "_terms_enum.yaml#/ebf1/common" + ECT2L: + $ref: + - "_terms_enum.yaml#/ect2l/common" + EED: + $ref: + - "_terms_enum.yaml#/eed/common" + EGFR: + $ref: + - "_terms_enum.yaml#/egfr/common" + EIF1AX: + $ref: + - "_terms_enum.yaml#/eif1ax/common" + EIF3E: + $ref: + - "_terms_enum.yaml#/eif3e/common" + EIF4A2: + $ref: + - "_terms_enum.yaml#/eif4a2/common" + ELF3: + $ref: + - "_terms_enum.yaml#/elf3/common" + ELF4: + $ref: + - "_terms_enum.yaml#/elf4/common" + ELK4: + $ref: + - "_terms_enum.yaml#/elk4/common" + ELL: + $ref: + - "_terms_enum.yaml#/ell/common" + ELN: + $ref: + - "_terms_enum.yaml#/eln/common" + EML4: + $ref: + - "_terms_enum.yaml#/eml4/common" + EP300: + $ref: + - "_terms_enum.yaml#/ep300/common" + EPAS1: + $ref: + - "_terms_enum.yaml#/epas1/common" + EPHA3: + $ref: + - "_terms_enum.yaml#/epha3/common" + EPHA7: + $ref: + - "_terms_enum.yaml#/epha7/common" + EPS15: + $ref: + - "_terms_enum.yaml#/eps15/common" + ERBB2: + $ref: + - "_terms_enum.yaml#/erbb2/common" + ERBB3: + $ref: + - "_terms_enum.yaml#/erbb3/common" + ERBB4: + $ref: + - "_terms_enum.yaml#/erbb4/common" + ERC1: + $ref: + - "_terms_enum.yaml#/erc1/common" + ERCC2: + $ref: + - "_terms_enum.yaml#/ercc2/common" + ERCC3: + $ref: + - "_terms_enum.yaml#/ercc3/common" + ERCC4: + $ref: + - "_terms_enum.yaml#/ercc4/common" + ERCC5: + $ref: + - "_terms_enum.yaml#/ercc5/common" + ERG: + $ref: + - "_terms_enum.yaml#/erg/common" + ESR1: + $ref: + - "_terms_enum.yaml#/esr1/common" + ETNK1: + $ref: + - "_terms_enum.yaml#/etnk1/common" + ETV1: + $ref: + - "_terms_enum.yaml#/etv1/common" + ETV4: + $ref: + - "_terms_enum.yaml#/etv4/common" + ETV5: + $ref: + - "_terms_enum.yaml#/etv5/common" + ETV6: + $ref: + - "_terms_enum.yaml#/etv6/common" + EWSR1: + $ref: + - "_terms_enum.yaml#/ewsr1/common" + EXT1: + $ref: + - "_terms_enum.yaml#/ext1/common" + EXT2: + $ref: + - "_terms_enum.yaml#/ext2/common" + EZH2: + $ref: + - "_terms_enum.yaml#/ezh2/common" + EZR: + $ref: + - "_terms_enum.yaml#/ezr/common" + FAM46C: + $ref: + - "_terms_enum.yaml#/fam46c/common" + FAM47C: + $ref: + - "_terms_enum.yaml#/fam47c/common" + FAM131B: + $ref: + - "_terms_enum.yaml#/fam131b/common" + FAM135B: + $ref: + - "_terms_enum.yaml#/fam135b/common" + FANCA: + $ref: + - "_terms_enum.yaml#/fanca/common" + FANCC: + $ref: + - "_terms_enum.yaml#/fancc/common" + FANCD2: + $ref: + - "_terms_enum.yaml#/fancd2/common" + FANCE: + $ref: + - "_terms_enum.yaml#/fance/common" + FANCF: + $ref: + - "_terms_enum.yaml#/fancf/common" + FANCG: + $ref: + - "_terms_enum.yaml#/fancg/common" + FAS: + $ref: + - "_terms_enum.yaml#/fas/common" + FAT1: + $ref: + - "_terms_enum.yaml#/fat1/common" + FAT3: + $ref: + - "_terms_enum.yaml#/fat3/common" + FAT4: + $ref: + - "_terms_enum.yaml#/fat4/common" + FBLN2: + $ref: + - "_terms_enum.yaml#/fbln2/common" + FBXO11: + $ref: + - "_terms_enum.yaml#/fbxo11/common" + FBXW7: + $ref: + - "_terms_enum.yaml#/fbxw7/common" + FCGR2B: + $ref: + - "_terms_enum.yaml#/fcgr2b/common" + FCRL4: + $ref: + - "_terms_enum.yaml#/fcrl4/common" + FEN1: + $ref: + - "_terms_enum.yaml#/fen1/common" + FES: + $ref: + - "_terms_enum.yaml#/fes/common" + FEV: + $ref: + - "_terms_enum.yaml#/fev/common" + FGFR1: + $ref: + - "_terms_enum.yaml#/fgfr1/common" + FGFR1OP: + $ref: + - "_terms_enum.yaml#/fgfr1op/common" + FGFR2: + $ref: + - "_terms_enum.yaml#/fgfr2/common" + FGFR3: + $ref: + - "_terms_enum.yaml#/fgfr3/common" + FGFR4: + $ref: + - "_terms_enum.yaml#/fgfr4/common" + FH: + $ref: + - "_terms_enum.yaml#/fh/common" + FHIT: + $ref: + - "_terms_enum.yaml#/fhit/common" + FIP1L1: + $ref: + - "_terms_enum.yaml#/fip1l1/common" + FKBP9: + $ref: + - "_terms_enum.yaml#/fkbp9/common" + FLCN: + $ref: + - "_terms_enum.yaml#/flcn/common" + FLI1: + $ref: + - "_terms_enum.yaml#/fli1/common" + FLNA: + $ref: + - "_terms_enum.yaml#/flna/common" + FLT3: + $ref: + - "_terms_enum.yaml#/flt3/common" + FLT4: + $ref: + - "_terms_enum.yaml#/flt4/common" + FNBP1: + $ref: + - "_terms_enum.yaml#/fnbp1/common" + FOXA1: + $ref: + - "_terms_enum.yaml#/foxa1/common" + FOXL2: + $ref: + - "_terms_enum.yaml#/foxl2/common" + FOXO1: + $ref: + - "_terms_enum.yaml#/foxo1/common" + FOXO3: + $ref: + - "_terms_enum.yaml#/foxo3/common" + FOXO4: + $ref: + - "_terms_enum.yaml#/foxo4/common" + FOXP1: + $ref: + - "_terms_enum.yaml#/foxp1/common" + FOXR1: + $ref: + - "_terms_enum.yaml#/foxr1/common" + FRYL: + $ref: + - "_terms_enum.yaml#/fryl/common" + FSTL3: + $ref: + - "_terms_enum.yaml#/fstl3/common" + FUBP1: + $ref: + - "_terms_enum.yaml#/fubp1/common" + FUS: + $ref: + - "_terms_enum.yaml#/fus/common" + GAS7: + $ref: + - "_terms_enum.yaml#/gas7/common" + GATA1: + $ref: + - "_terms_enum.yaml#/gata1/common" + GATA2: + $ref: + - "_terms_enum.yaml#/gata2/common" + GATA3: + $ref: + - "_terms_enum.yaml#/gata3/common" + GLI1: + $ref: + - "_terms_enum.yaml#/gli1/common" + GLIS2: + $ref: + - "_terms_enum.yaml#/glis2/common" + GMPS: + $ref: + - "_terms_enum.yaml#/gmps/common" + GNA11: + $ref: + - "_terms_enum.yaml#/gna11/common" + GNAQ: + $ref: + - "_terms_enum.yaml#/gnaq/common" + GNAS: + $ref: + - "_terms_enum.yaml#/gnas/common" + GOLGA5: + $ref: + - "_terms_enum.yaml#/golga5/common" + GOPC: + $ref: + - "_terms_enum.yaml#/gopc/common" + GPC3: + $ref: + - "_terms_enum.yaml#/gpc3/common" + GPHN: + $ref: + - "_terms_enum.yaml#/gphn/common" + GRIN2A: + $ref: + - "_terms_enum.yaml#/grin2a/common" + GRM3: + $ref: + - "_terms_enum.yaml#/grm3/common" + H3F3A: + $ref: + - "_terms_enum.yaml#/h3f3a/common" + H3F3B: + $ref: + - "_terms_enum.yaml#/h3f3b/common" + HERPUD1: + $ref: + - "_terms_enum.yaml#/herpud1/common" + HEY1: + $ref: + - "_terms_enum.yaml#/hey1/common" + HIF1A: + $ref: + - "_terms_enum.yaml#/hif1a/common" + HIP1: + $ref: + - "_terms_enum.yaml#/hip1/common" + HIST1H3B: + $ref: + - "_terms_enum.yaml#/hist1h3b/common" + HIST1H4I: + $ref: + - "_terms_enum.yaml#/hist1h4i/common" + HLA-A: + $ref: + - "_terms_enum.yaml#/hlaa/common" + HLF: + $ref: + - "_terms_enum.yaml#/hlf/common" + HMGA1: + $ref: + - "_terms_enum.yaml#/hmga1/common" + HMGA2: + $ref: + - "_terms_enum.yaml#/hmga2/common" + HMGB3: + $ref: + - "_terms_enum.yaml#/hmgb3/common" + HMGN2P46: + $ref: + - "_terms_enum.yaml#/hmgn2p46/common" + HNF1A: + $ref: + - "_terms_enum.yaml#/hnf1a/common" + HNRNPA2B1: + $ref: + - "_terms_enum.yaml#/hnrnpa2b1/common" + HOOK3: + $ref: + - "_terms_enum.yaml#/hook3/common" + HOXA9: + $ref: + - "_terms_enum.yaml#/hoxa9/common" + HOXA11: + $ref: + - "_terms_enum.yaml#/hoxa11/common" + HOXA13: + $ref: + - "_terms_enum.yaml#/hoxa13/common" + HOXB1: + $ref: + - "_terms_enum.yaml#/hoxb1/common" + HOXC11: + $ref: + - "_terms_enum.yaml#/hoxc11/common" + HOXC13: + $ref: + - "_terms_enum.yaml#/hoxc13/common" + HOXD11: + $ref: + - "_terms_enum.yaml#/hoxd11/common" + HOXD13: + $ref: + - "_terms_enum.yaml#/hoxd13/common" + HRAS: + $ref: + - "_terms_enum.yaml#/hras/common" + HSP90AA1: + $ref: + - "_terms_enum.yaml#/hsp90aa1/common" + HSP90AB1: + $ref: + - "_terms_enum.yaml#/hsp90ab1/common" + ID3: + $ref: + - "_terms_enum.yaml#/id3/common" + IDH1: + $ref: + - "_terms_enum.yaml#/idh1/common" + IDH2: + $ref: + - "_terms_enum.yaml#/idh2/common" + IGH: + $ref: + - "_terms_enum.yaml#/igh/common" + IGK: + $ref: + - "_terms_enum.yaml#/igk/common" + IGKC: + $ref: + - "_terms_enum.yaml#/igkc/common" + IGL: + $ref: + - "_terms_enum.yaml#/igl/common" + IKBKB: + $ref: + - "_terms_enum.yaml#/ikbkb/common" + IKZF1: + $ref: + - "_terms_enum.yaml#/ikzf1/common" + IL2: + $ref: + - "_terms_enum.yaml#/il2/common" + IL6ST: + $ref: + - "_terms_enum.yaml#/il6st/common" + IL7R: + $ref: + - "_terms_enum.yaml#/il7r/common" + IL21R: + $ref: + - "_terms_enum.yaml#/il21r/common" + INO80D: + $ref: + - "_terms_enum.yaml#/ino80d/common" + IRF4: + $ref: + - "_terms_enum.yaml#/irf4/common" + IRS4: + $ref: + - "_terms_enum.yaml#/irs4/common" + ISX: + $ref: + - "_terms_enum.yaml#/isx/common" + ITGAV: + $ref: + - "_terms_enum.yaml#/itgav/common" + ITK: + $ref: + - "_terms_enum.yaml#/itk/common" + JAK1: + $ref: + - "_terms_enum.yaml#/jak1/common" + JAK2: + $ref: + - "_terms_enum.yaml#/jak2/common" + JAK3: + $ref: + - "_terms_enum.yaml#/jak3/common" + JAZF1: + $ref: + - "_terms_enum.yaml#/jazf1/common" + JUN: + $ref: + - "_terms_enum.yaml#/jun/common" + KAT6A: + $ref: + - "_terms_enum.yaml#/kat6a/common" + KAT6B: + $ref: + - "_terms_enum.yaml#/kat6b/common" + KAT7: + $ref: + - "_terms_enum.yaml#/kat7/common" + KCNJ5: + $ref: + - "_terms_enum.yaml#/kcnj5/common" + KDM5A: + $ref: + - "_terms_enum.yaml#/kdm5a/common" + KDM5C: + $ref: + - "_terms_enum.yaml#/kdm5c/common" + KDM6A: + $ref: + - "_terms_enum.yaml#/kdm6a/common" + KDR: + $ref: + - "_terms_enum.yaml#/kdr/common" + KDSR: + $ref: + - "_terms_enum.yaml#/kdsr/common" + KEAP1: + $ref: + - "_terms_enum.yaml#/keap1/common" + KIAA1549: + $ref: + - "_terms_enum.yaml#/kiaa1549/common" + KIF5B: + $ref: + - "_terms_enum.yaml#/kif5b/common" + KIT: + $ref: + - "_terms_enum.yaml#/kit/common" + KLF4: + $ref: + - "_terms_enum.yaml#/klf4/common" + KLF6: + $ref: + - "_terms_enum.yaml#/klf6/common" + KLK2: + $ref: + - "_terms_enum.yaml#/klk2/common" + KMT2A: + $ref: + - "_terms_enum.yaml#/kmt2a/common" + KMT2C: + $ref: + - "_terms_enum.yaml#/kmt2c/common" + KMT2D: + $ref: + - "_terms_enum.yaml#/kmt2d/common" + KNL1: + $ref: + - "_terms_enum.yaml#/knl1/common" + KNSTRN: + $ref: + - "_terms_enum.yaml#/knstrn/common" + KRAS: + $ref: + - "_terms_enum.yaml#/kras/common" + KRT7: + $ref: + - "_terms_enum.yaml#/krt7/common" + KRT20: + $ref: + - "_terms_enum.yaml#/krt20/common" + KTN1: + $ref: + - "_terms_enum.yaml#/ktn1/common" + LARP4B: + $ref: + - "_terms_enum.yaml#/larp4b/common" + LASP1: + $ref: + - "_terms_enum.yaml#/lasp1/common" + LCK: + $ref: + - "_terms_enum.yaml#/lck/common" + LCP1: + $ref: + - "_terms_enum.yaml#/lcp1/common" + LEF1: + $ref: + - "_terms_enum.yaml#/lef1/common" + LHFP: + $ref: + - "_terms_enum.yaml#/lhfp/common" + LIFR: + $ref: + - "_terms_enum.yaml#/lifr/common" + LMNA: + $ref: + - "_terms_enum.yaml#/lmna/common" + LMO1: + $ref: + - "_terms_enum.yaml#/lmo1/common" + LMO2: + $ref: + - "_terms_enum.yaml#/lmo2/common" + LPP: + $ref: + - "_terms_enum.yaml#/lpp/common" + LRIG3: + $ref: + - "_terms_enum.yaml#/lrig3/common" + LRP1B: + $ref: + - "_terms_enum.yaml#/lrp1b/common" + LSM14A: + $ref: + - "_terms_enum.yaml#/lsm14a/common" + LYL1: + $ref: + - "_terms_enum.yaml#/lyl1/common" + LZTR1: + $ref: + - "_terms_enum.yaml#/lztr1/common" + MAF: + $ref: + - "_terms_enum.yaml#/maf/molecular_test/gene_symbol" + MAFB: + $ref: + - "_terms_enum.yaml#/mafb/common" + MALAT1: + $ref: + - "_terms_enum.yaml#/malat1/common" + MALT1: + $ref: + - "_terms_enum.yaml#/malt1/common" + MAML2: + $ref: + - "_terms_enum.yaml#/maml2/common" + MAML3: + $ref: + - "_terms_enum.yaml#/maml3/common" + MAP2K1: + $ref: + - "_terms_enum.yaml#/map2k1/common" + MAP2K2: + $ref: + - "_terms_enum.yaml#/map2k2/common" + MAP2K4: + $ref: + - "_terms_enum.yaml#/map2k4/common" + MAP3K1: + $ref: + - "_terms_enum.yaml#/map3k1/common" + MAP3K13: + $ref: + - "_terms_enum.yaml#/map3k13/common" + MAPK1: + $ref: + - "_terms_enum.yaml#/mapk1/common" + MAX: + $ref: + - "_terms_enum.yaml#/max/common" + MB21D2: + $ref: + - "_terms_enum.yaml#/mb21d2/common" + MDM2: + $ref: + - "_terms_enum.yaml#/mdm2/common" + MDM4: + $ref: + - "_terms_enum.yaml#/mdm4/common" + MDS2: + $ref: + - "_terms_enum.yaml#/mds2/common" + MECOM: + $ref: + - "_terms_enum.yaml#/mecom/common" + MED12: + $ref: + - "_terms_enum.yaml#/med12/common" + MEN1: + $ref: + - "_terms_enum.yaml#/men1/common" + MET: + $ref: + - "_terms_enum.yaml#/met/common" + MGMT: + $ref: + - "_terms_enum.yaml#/mgmt/common" + MIB1: + $ref: + - "_terms_enum.yaml#/mib1/common" + MITF: + $ref: + - "_terms_enum.yaml#/mitf/common" + MKL1: + $ref: + - "_terms_enum.yaml#/mkl1/common" + MLF1: + $ref: + - "_terms_enum.yaml#/mlf1/common" + MLH1: + $ref: + - "_terms_enum.yaml#/mlh1/common" + MLH2: + $ref: + - "_terms_enum.yaml#/mlh2/common" + MLLT1: + $ref: + - "_terms_enum.yaml#/mllt1/common" + MLLT3: + $ref: + - "_terms_enum.yaml#/mllt3/common" + MLLT4: + $ref: + - "_terms_enum.yaml#/mllt4/common" + MLLT6: + $ref: + - "_terms_enum.yaml#/mllt6/common" + MLLT10: + $ref: + - "_terms_enum.yaml#/mllt10/common" + MLLT11: + $ref: + - "_terms_enum.yaml#/mllt11/common" + MN1: + $ref: + - "_terms_enum.yaml#/mn1/common" + MNX1: + $ref: + - "_terms_enum.yaml#/mnx1/common" + MPL: + $ref: + - "_terms_enum.yaml#/mpl/common" + MSH2: + $ref: + - "_terms_enum.yaml#/msh2/common" + MSH6: + $ref: + - "_terms_enum.yaml#/msh6/common" + MSI2: + $ref: + - "_terms_enum.yaml#/msi2/common" + MSN: + $ref: + - "_terms_enum.yaml#/msn/common" + MTCP1: + $ref: + - "_terms_enum.yaml#/mtcp1/common" + MTOR: + $ref: + - "_terms_enum.yaml#/mtor/common" + MUC1: + $ref: + - "_terms_enum.yaml#/muc1/common" + MUC4: + $ref: + - "_terms_enum.yaml#/muc4/common" + MUC16: + $ref: + - "_terms_enum.yaml#/muc16/common" + MUTYH: + $ref: + - "_terms_enum.yaml#/mutyh/common" + MYB: + $ref: + - "_terms_enum.yaml#/myb/common" + MYC: + $ref: + - "_terms_enum.yaml#/myc/common" + MYCL: + $ref: + - "_terms_enum.yaml#/mycl/common" + MYCN: + $ref: + - "_terms_enum.yaml#/mycn/common" + MYD88: + $ref: + - "_terms_enum.yaml#/myd88/common" + MYH9: + $ref: + - "_terms_enum.yaml#/myh9/common" + MYH11: + $ref: + - "_terms_enum.yaml#/myh11/common" + MYO5A: + $ref: + - "_terms_enum.yaml#/myo5a/common" + MYOD1: + $ref: + - "_terms_enum.yaml#/myod1/common" + NAB2: + $ref: + - "_terms_enum.yaml#/nab2/common" + NACA: + $ref: + - "_terms_enum.yaml#/naca/common" + NBEA: + $ref: + - "_terms_enum.yaml#/nbea/common" + NBN: + $ref: + - "_terms_enum.yaml#/nbn/common" + NCKIPSD: + $ref: + - "_terms_enum.yaml#/nckipsd/common" + NCOA1: + $ref: + - "_terms_enum.yaml#/ncoa1/common" + NCOA2: + $ref: + - "_terms_enum.yaml#/ncoa2/common" + NCOA4: + $ref: + - "_terms_enum.yaml#/ncoa4/common" + NCOR1: + $ref: + - "_terms_enum.yaml#/ncor1/common" + NCOR2: + $ref: + - "_terms_enum.yaml#/ncor2/common" + NDRG1: + $ref: + - "_terms_enum.yaml#/ndrg1/common" + NF1: + $ref: + - "_terms_enum.yaml#/nf1/common" + NF2: + $ref: + - "_terms_enum.yaml#/nf2/common" + NFATC2: + $ref: + - "_terms_enum.yaml#/nfatc2/common" + NFE2L2: + $ref: + - "_terms_enum.yaml#/nfe2l2/common" + NFIB: + $ref: + - "_terms_enum.yaml#/nfib/common" + NFKB2: + $ref: + - "_terms_enum.yaml#/nfkb2/common" + NFKBIE: + $ref: + - "_terms_enum.yaml#/nfkbie/common" + NIN: + $ref: + - "_terms_enum.yaml#/nin/common" + NKX2-1: + $ref: + - "_terms_enum.yaml#/nkx21/common" + NONO: + $ref: + - "_terms_enum.yaml#/nono/common" + NOTCH1: + $ref: + - "_terms_enum.yaml#/notch1/common" + NOTCH2: + $ref: + - "_terms_enum.yaml#/notch2/common" + NPM1: + $ref: + - "_terms_enum.yaml#/npm1/common" + NR4A3: + $ref: + - "_terms_enum.yaml#/nr4a3/common" + NRAS: + $ref: + - "_terms_enum.yaml#/nras/common" + NRG1: + $ref: + - "_terms_enum.yaml#/nrg1/common" + NSD1: + $ref: + - "_terms_enum.yaml#/nsd1/common" + NSD2: + $ref: + - "_terms_enum.yaml#/nsd2/common" + NSD3: + $ref: + - "_terms_enum.yaml#/nsd3/common" + NT5C2: + $ref: + - "_terms_enum.yaml#/nt5c2/common" + NTHL1: + $ref: + - "_terms_enum.yaml#/nthl1/common" + NTRK1: + $ref: + - "_terms_enum.yaml#/ntrk1/common" + NTRK3: + $ref: + - "_terms_enum.yaml#/ntrk3/common" + NUMA1: + $ref: + - "_terms_enum.yaml#/numa1/common" + NUP98: + $ref: + - "_terms_enum.yaml#/nup98/common" + NUP214: + $ref: + - "_terms_enum.yaml#/nup214/common" + NUTM1: + $ref: + - "_terms_enum.yaml#/nutm1/common" + NUTM2A: + $ref: + - "_terms_enum.yaml#/nutm2a/common" + NUTM2B: + $ref: + - "_terms_enum.yaml#/nutm2b/common" + OLIG2: + $ref: + - "_terms_enum.yaml#/olig2/common" + OMD: + $ref: + - "_terms_enum.yaml#/omd/common" + P2RY8: + $ref: + - "_terms_enum.yaml#/p2ry8/common" + PABPC1: + $ref: + - "_terms_enum.yaml#/pabpc1/common" + PAFAH1B2: + $ref: + - "_terms_enum.yaml#/pafah1b2/common" + PALB2: + $ref: + - "_terms_enum.yaml#/palb2/common" + PATZ1: + $ref: + - "_terms_enum.yaml#/patz1/common" + PAX3: + $ref: + - "_terms_enum.yaml#/pax3/common" + PAX5: + $ref: + - "_terms_enum.yaml#/pax5/common" + PAX7: + $ref: + - "_terms_enum.yaml#/pax7/common" + PAX8: + $ref: + - "_terms_enum.yaml#/pax8/common" + PBRM1: + $ref: + - "_terms_enum.yaml#/pbrm1/common" + PBX1: + $ref: + - "_terms_enum.yaml#/pbx1/common" + PCBP1: + $ref: + - "_terms_enum.yaml#/pcbp1/common" + PCM1: + $ref: + - "_terms_enum.yaml#/pcm1/common" + PDCD1LG2: + $ref: + - "_terms_enum.yaml#/pdcd1lg2/common" + PDE4DIP: + $ref: + - "_terms_enum.yaml#/pde4dip/common" + PDGFB: + $ref: + - "_terms_enum.yaml#/pdgfb/common" + PDGFRA: + $ref: + - "_terms_enum.yaml#/pdgfra/common" + PDGFRB: + $ref: + - "_terms_enum.yaml#/pdgfrb/common" + PER1: + $ref: + - "_terms_enum.yaml#/per1/common" + PGR: + $ref: + - "_terms_enum.yaml#/pgr/common" + PHF6: + $ref: + - "_terms_enum.yaml#/phf6/common" + PHF23: + $ref: + - "_terms_enum.yaml#/phf23/common" + PHOX2B: + $ref: + - "_terms_enum.yaml#/phox2b/common" + PICALM: + $ref: + - "_terms_enum.yaml#/picalm/common" + PIK3CA: + $ref: + - "_terms_enum.yaml#/pik3ca/common" + PIK3CB: + $ref: + - "_terms_enum.yaml#/pik3cb/common" + PIK3R1: + $ref: + - "_terms_enum.yaml#/pik3r1/common" + PIM1: + $ref: + - "_terms_enum.yaml#/pim1/common" + PIM3: + $ref: + - "_terms_enum.yaml#/pim3/common" + PLAG1: + $ref: + - "_terms_enum.yaml#/plag1/common" + PLCG1: + $ref: + - "_terms_enum.yaml#/plcg1/common" + PML: + $ref: + - "_terms_enum.yaml#/pml/common" + PMS1: + $ref: + - "_terms_enum.yaml#/pms1/common" + PMS2: + $ref: + - "_terms_enum.yaml#/pms2/common" + POLD1: + $ref: + - "_terms_enum.yaml#/pold1/common" + POLE: + $ref: + - "_terms_enum.yaml#/pole/common" + POLG: + $ref: + - "_terms_enum.yaml#/polg/common" + POLQ: + $ref: + - "_terms_enum.yaml#/polq/common" + POT1: + $ref: + - "_terms_enum.yaml#/pot1/common" + POU2AF1: + $ref: + - "_terms_enum.yaml#/pou2af1/common" + POU5F1: + $ref: + - "_terms_enum.yaml#/pou5f1/common" + PPARG: + $ref: + - "_terms_enum.yaml#/pparg/common" + PPFIBP1: + $ref: + - "_terms_enum.yaml#/ppfibp1/common" + PPM1D: + $ref: + - "_terms_enum.yaml#/ppm1d/common" + PPP2R1A: + $ref: + - "_terms_enum.yaml#/ppp2r1a/common" + PPP6C: + $ref: + - "_terms_enum.yaml#/ppp6c/common" + PRCC: + $ref: + - "_terms_enum.yaml#/prcc/common" + PRDM1: + $ref: + - "_terms_enum.yaml#/prdm1/common" + PRDM2: + $ref: + - "_terms_enum.yaml#/prdm2/common" + PRDM16: + $ref: + - "_terms_enum.yaml#/prdm16/common" + PREX2: + $ref: + - "_terms_enum.yaml#/prex2/common" + PRF1: + $ref: + - "_terms_enum.yaml#/prf1/common" + PRKACA: + $ref: + - "_terms_enum.yaml#/prkaca/common" + PRKAR1A: + $ref: + - "_terms_enum.yaml#/prkar1a/common" + PRKCB: + $ref: + - "_terms_enum.yaml#/prkcb/common" + PRPF40B: + $ref: + - "_terms_enum.yaml#/prpf40b/common" + PRRX1: + $ref: + - "_terms_enum.yaml#/prrx1/common" + PSIP1: + $ref: + - "_terms_enum.yaml#/psip1/common" + PTCH1: + $ref: + - "_terms_enum.yaml#/ptch1/common" + PTEN: + $ref: + - "_terms_enum.yaml#/pten/common" + PTK6: + $ref: + - "_terms_enum.yaml#/ptk6/common" + PTP4A1: + $ref: + - "_terms_enum.yaml#/ptp4a1/common" + PTPN6: + $ref: + - "_terms_enum.yaml#/ptpn6/common" + PTPN11: + $ref: + - "_terms_enum.yaml#/ptpn11/common" + PTPN13: + $ref: + - "_terms_enum.yaml#/ptpn13/common" + PTPRB: + $ref: + - "_terms_enum.yaml#/ptprb/common" + PTPRC: + $ref: + - "_terms_enum.yaml#/ptprc/common" + PTPRK: + $ref: + - "_terms_enum.yaml#/ptprk/common" + PTPRT: + $ref: + - "_terms_enum.yaml#/ptprt/common" + PWWP2A: + $ref: + - "_terms_enum.yaml#/pwwp2a/common" + QKI: + $ref: + - "_terms_enum.yaml#/qki/common" + RABEP1: + $ref: + - "_terms_enum.yaml#/rabep1/common" + RAC1: + $ref: + - "_terms_enum.yaml#/rac1/common" + RAD21: + $ref: + - "_terms_enum.yaml#/rad21/common" + RAD51B: + $ref: + - "_terms_enum.yaml#/rad51b/common" + RAF1: + $ref: + - "_terms_enum.yaml#/raf1/common" + RALGDS: + $ref: + - "_terms_enum.yaml#/ralgds/common" + RANBP2: + $ref: + - "_terms_enum.yaml#/ranbp2/common" + RAP1GDS1: + $ref: + - "_terms_enum.yaml#/rap1gds1/common" + RARA: + $ref: + - "_terms_enum.yaml#/rara/common" + RB1: + $ref: + - "_terms_enum.yaml#/rb1/common" + RBM10: + $ref: + - "_terms_enum.yaml#/rbm10/common" + RBM15: + $ref: + - "_terms_enum.yaml#/rbm15/common" + RECQL4: + $ref: + - "_terms_enum.yaml#/recql4/common" + REL: + $ref: + - "_terms_enum.yaml#/rel/common" + RET: + $ref: + - "_terms_enum.yaml#/ret/common" + RGPD3: + $ref: + - "_terms_enum.yaml#/rgpd3/common" + RGS7: + $ref: + - "_terms_enum.yaml#/rgs7/common" + RHOA: + $ref: + - "_terms_enum.yaml#/rhoa/common" + RHOH: + $ref: + - "_terms_enum.yaml#/rhoh/common" + RMI2: + $ref: + - "_terms_enum.yaml#/rmi2/common" + RNF43: + $ref: + - "_terms_enum.yaml#/rnf43/common" + RNF213: + $ref: + - "_terms_enum.yaml#/rnf213/common" + ROBO2: + $ref: + - "_terms_enum.yaml#/robo2/common" + ROS1: + $ref: + - "_terms_enum.yaml#/ros1/common" + RPL5: + $ref: + - "_terms_enum.yaml#/rpl5/common" + RPL10: + $ref: + - "_terms_enum.yaml#/rpl10/common" + RPL22: + $ref: + - "_terms_enum.yaml#/rpl22/common" + RPN1: + $ref: + - "_terms_enum.yaml#/rpn1/common" + RSPO2: + $ref: + - "_terms_enum.yaml#/rspo2/common" + RSPO3: + $ref: + - "_terms_enum.yaml#/rspo3/common" + RUNX1: + $ref: + - "_terms_enum.yaml#/runx1/common" + RUNX1T1: + $ref: + - "_terms_enum.yaml#/runx1t1/common" + S100A7: + $ref: + - "_terms_enum.yaml#/s100a7/common" + SALL4: + $ref: + - "_terms_enum.yaml#/sall4/common" + SBDS: + $ref: + - "_terms_enum.yaml#/sbds/common" + SDC4: + $ref: + - "_terms_enum.yaml#/sdc4/common" + SDHA: + $ref: + - "_terms_enum.yaml#/sdha/common" + SDHAF2: + $ref: + - "_terms_enum.yaml#/sdhaf2/common" + SDHB: + $ref: + - "_terms_enum.yaml#/sdhb/common" + SDHC: + $ref: + - "_terms_enum.yaml#/sdhc/common" + SDHD: + $ref: + - "_terms_enum.yaml#/sdhd/common" + SEPT5: + $ref: + - "_terms_enum.yaml#/sept5/common" + SEPT6: + $ref: + - "_terms_enum.yaml#/sept6/common" + SEPT9: + $ref: + - "_terms_enum.yaml#/sept9/common" + SET: + $ref: + - "_terms_enum.yaml#/set/common" + SETBP1: + $ref: + - "_terms_enum.yaml#/setbp1/common" + SETD2: + $ref: + - "_terms_enum.yaml#/setd2/common" + SF3B1: + $ref: + - "_terms_enum.yaml#/sf3b1/common" + SFPQ: + $ref: + - "_terms_enum.yaml#/sfpq/common" + SFRP4: + $ref: + - "_terms_enum.yaml#/sfrp4/common" + SGK1: + $ref: + - "_terms_enum.yaml#/sgk1/common" + SH2B3: + $ref: + - "_terms_enum.yaml#/sh2b3/common" + SH3GL1: + $ref: + - "_terms_enum.yaml#/sh3gl1/common" + SHTN1: + $ref: + - "_terms_enum.yaml#/shtn1/common" + SIRPA: + $ref: + - "_terms_enum.yaml#/sirpa/common" + SKI: + $ref: + - "_terms_enum.yaml#/ski/common" + SLC34A2: + $ref: + - "_terms_enum.yaml#/slc34a2/common" + SLC45A3: + $ref: + - "_terms_enum.yaml#/slc45a3/common" + SMAD2: + $ref: + - "_terms_enum.yaml#/smad2/common" + SMAD3: + $ref: + - "_terms_enum.yaml#/smad3/common" + SMAD4: + $ref: + - "_terms_enum.yaml#/smad4/common" + SMARCA4: + $ref: + - "_terms_enum.yaml#/smarca4/common" + SMARCB1: + $ref: + - "_terms_enum.yaml#/smarcb1/common" + SMARCD1: + $ref: + - "_terms_enum.yaml#/smarcd1/common" + SMARCE1: + $ref: + - "_terms_enum.yaml#/smarce1/common" + SMC1A: + $ref: + - "_terms_enum.yaml#/smc1a/common" + SMO: + $ref: + - "_terms_enum.yaml#/smo/common" + SND1: + $ref: + - "_terms_enum.yaml#/snd1/common" + SNX29: + $ref: + - "_terms_enum.yaml#/snx29/common" + SOCS1: + $ref: + - "_terms_enum.yaml#/socs1/common" + SOX2: + $ref: + - "_terms_enum.yaml#/sox2/common" + SPECC1: + $ref: + - "_terms_enum.yaml#/specc1/common" + SPEN: + $ref: + - "_terms_enum.yaml#/spen/common" + SPOP: + $ref: + - "_terms_enum.yaml#/spop/common" + SRC: + $ref: + - "_terms_enum.yaml#/src/common" + SRGAP3: + $ref: + - "_terms_enum.yaml#/srgap3/common" + SRSF2: + $ref: + - "_terms_enum.yaml#/srsf2/common" + SRSF3: + $ref: + - "_terms_enum.yaml#/srsf3/common" + SS18: + $ref: + - "_terms_enum.yaml#/ss18/common" + SS18L1: + $ref: + - "_terms_enum.yaml#/ss18l1/common" + SSX1: + $ref: + - "_terms_enum.yaml#/ssx1/common" + SSX2: + $ref: + - "_terms_enum.yaml#/ssx2/common" + SSX4: + $ref: + - "_terms_enum.yaml#/ssx4/common" + STAG1: + $ref: + - "_terms_enum.yaml#/stag1/common" + STAG2: + $ref: + - "_terms_enum.yaml#/stag2/common" + STAT3: + $ref: + - "_terms_enum.yaml#/stat3/common" + STAT5B: + $ref: + - "_terms_enum.yaml#/stat5b/common" + STAT6: + $ref: + - "_terms_enum.yaml#/stat6/common" + STIL: + $ref: + - "_terms_enum.yaml#/stil/common" + STK11: + $ref: + - "_terms_enum.yaml#/stk11/common" + STRN: + $ref: + - "_terms_enum.yaml#/strn/common" + SUFU: + $ref: + - "_terms_enum.yaml#/sufu/common" + SUZ12: + $ref: + - "_terms_enum.yaml#/suz12/common" + SYK: + $ref: + - "_terms_enum.yaml#/syk/common" + SYP: + $ref: + - "_terms_enum.yaml#/syp/common" + TAF15: + $ref: + - "_terms_enum.yaml#/taf15/common" + TAL1: + $ref: + - "_terms_enum.yaml#/tal1/common" + TAL2: + $ref: + - "_terms_enum.yaml#/tal2/common" + TBL1XR1: + $ref: + - "_terms_enum.yaml#/tbl1xr1/common" + TBX3: + $ref: + - "_terms_enum.yaml#/tbx3/common" + TCEA1: + $ref: + - "_terms_enum.yaml#/tcea1/common" + TCF3: + $ref: + - "_terms_enum.yaml#/tcf3/common" + TCF7L2: + $ref: + - "_terms_enum.yaml#/tcf7l2/common" + TCF12: + $ref: + - "_terms_enum.yaml#/tcf12/common" + TCL1A: + $ref: + - "_terms_enum.yaml#/tcl1a/common" + TEC: + $ref: + - "_terms_enum.yaml#/tec/common" + TERT: + $ref: + - "_terms_enum.yaml#/tert/common" + TET1: + $ref: + - "_terms_enum.yaml#/tet1/common" + TET2: + $ref: + - "_terms_enum.yaml#/tet2/common" + TFE3: + $ref: + - "_terms_enum.yaml#/tfe3/common" + TFEB: + $ref: + - "_terms_enum.yaml#/tfeb/common" + TFG: + $ref: + - "_terms_enum.yaml#/tfg/common" + TFPT: + $ref: + - "_terms_enum.yaml#/tfpt/common" + TFRC: + $ref: + - "_terms_enum.yaml#/tfrc/common" + TGFBR2: + $ref: + - "_terms_enum.yaml#/tgfbr2/common" + THRAP3: + $ref: + - "_terms_enum.yaml#/thrap3/common" + TLX1: + $ref: + - "_terms_enum.yaml#/tlx1/common" + TLX3: + $ref: + - "_terms_enum.yaml#/tlx3/common" + TMEM127: + $ref: + - "_terms_enum.yaml#/tmem127/common" + TMPRSS2: + $ref: + - "_terms_enum.yaml#/tmprss2/common" + TNC: + $ref: + - "_terms_enum.yaml#/tnc/common" + TNFAIP3: + $ref: + - "_terms_enum.yaml#/tnfaip3/common" + TNFRSF14: + $ref: + - "_terms_enum.yaml#/tnfrsf14/common" + TNFRSF17: + $ref: + - "_terms_enum.yaml#/tnfrsf17/common" + TOP1: + $ref: + - "_terms_enum.yaml#/top1/common" + TOP2B: + $ref: + - "_terms_enum.yaml#/top2b/common" + TP53: + $ref: + - "_terms_enum.yaml#/tp53/common" + TP63: + $ref: + - "_terms_enum.yaml#/tp63/common" + TPM3: + $ref: + - "_terms_enum.yaml#/tpm3/common" + TPM4: + $ref: + - "_terms_enum.yaml#/tpm4/common" + TPR: + $ref: + - "_terms_enum.yaml#/tpr/common" + TRA: + $ref: + - "_terms_enum.yaml#/tra/common" + TRAF7: + $ref: + - "_terms_enum.yaml#/traf7/common" + TRB: + $ref: + - "_terms_enum.yaml#/trb/common" + TRD: + $ref: + - "_terms_enum.yaml#/trd/common" + TRIM24: + $ref: + - "_terms_enum.yaml#/trim24/common" + TRIM27: + $ref: + - "_terms_enum.yaml#/trim27/common" + TRIM33: + $ref: + - "_terms_enum.yaml#/trim33/common" + TRIP11: + $ref: + - "_terms_enum.yaml#/trip11/common" + TRRAP: + $ref: + - "_terms_enum.yaml#/trrap/common" + TSC1: + $ref: + - "_terms_enum.yaml#/tsc1/common" + TSC2: + $ref: + - "_terms_enum.yaml#/tsc2/common" + TSHR: + $ref: + - "_terms_enum.yaml#/tshr/common" + U2AF1: + $ref: + - "_terms_enum.yaml#/u2af1/common" + UBB: + $ref: + - "_terms_enum.yaml#/ubb/common" + UBR5: + $ref: + - "_terms_enum.yaml#/ubr5/common" + USP6: + $ref: + - "_terms_enum.yaml#/usp6/common" + USP8: + $ref: + - "_terms_enum.yaml#/usp8/common" + VAV1: + $ref: + - "_terms_enum.yaml#/vav1/common" + VHL: + $ref: + - "_terms_enum.yaml#/vhl/common" + VTI1A: + $ref: + - "_terms_enum.yaml#/vti1a/common" + WAS: + $ref: + - "_terms_enum.yaml#/was/common" + WDCP: + $ref: + - "_terms_enum.yaml#/wdcp/common" + WIF1: + $ref: + - "_terms_enum.yaml#/wif1/common" + WNK2: + $ref: + - "_terms_enum.yaml#/wnk2/common" + WRN: + $ref: + - "_terms_enum.yaml#/wrn/common" + WT1: + $ref: + - "_terms_enum.yaml#/wt1/common" + WWTR1: + $ref: + - "_terms_enum.yaml#/wwtr1/common" + XPA: + $ref: + - "_terms_enum.yaml#/xpa/common" + XPC: + $ref: + - "_terms_enum.yaml#/xpc/common" + XPO1: + $ref: + - "_terms_enum.yaml#/xpo1/common" + YWHAE: + $ref: + - "_terms_enum.yaml#/ywhae/common" + ZBTB16: + $ref: + - "_terms_enum.yaml#/zbtb16/common" + ZCCHC8: + $ref: + - "_terms_enum.yaml#/zcchc8/common" + ZEB1: + $ref: + - "_terms_enum.yaml#/zeb1/common" + ZEB2: + $ref: + - "_terms_enum.yaml#/zeb2/common" + ZFHX3: + $ref: + - "_terms_enum.yaml#/zfhx3/common" + ZMYM3: + $ref: + - "_terms_enum.yaml#/zmym3/common" + ZNF198: + $ref: + - "_terms_enum.yaml#/znf198/common" + ZNF331: + $ref: + - "_terms_enum.yaml#/znf331/common" + ZNF384: + $ref: + - "_terms_enum.yaml#/znf384/common" + ZNF429: + $ref: + - "_terms_enum.yaml#/znf429/common" + ZNF444: + $ref: + - "_terms_enum.yaml#/znf444/common" + ZNF479: + $ref: + - "_terms_enum.yaml#/znf479/common" + ZNF521: + $ref: + - "_terms_enum.yaml#/znf521/common" + ZNRF3: + $ref: + - "_terms_enum.yaml#/znrf3/common" + ZRSR2: + $ref: + - "_terms_enum.yaml#/zrsr2/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + histone_family: + $ref: + - "_terms.yaml#/histone_family/common" + enum: + - H1 + - H2A + - H2B + - H3 + - H4 + - Unknown + - Not Reported + enumDef: + H1: + $ref: + - "_terms_enum.yaml#/h1/common" + H2A: + $ref: + - "_terms_enum.yaml#/h2a/common" + H2B: + $ref: + - "_terms_enum.yaml#/h2b/common" + H3: + $ref: + - "_terms_enum.yaml#/h3/common" + H4: + $ref: + - "_terms_enum.yaml#/h4/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + histone_variant: + $ref: + - "_terms.yaml#/histone_variant/common" + enum: + - CENP-A + - H2A-Bbd + - H2A.X + - H2A.Z + - H2A.Z.1 + - H2A.Z.2 + - H2A.Z.2.2 + - H3.1 + - H3.2 + - H3.3 + - H3.5 + - H3.X + - H3.Y + - H3t (H3.4) + - mH2A + - mH2A.1 + - mH2A.2 + - Unknown + - Not Reported + enumDef: + CENP-A: + $ref: + - "_terms_enum.yaml#/cenpa/common" + H2A-Bbd: + $ref: + - "_terms_enum.yaml#/h2abbd/common" + H2A.X: + $ref: + - "_terms_enum.yaml#/h2ax/common" + H2A.Z: + $ref: + - "_terms_enum.yaml#/h2az/common" + H2A.Z.1: + $ref: + - "_terms_enum.yaml#/h2az1/common" + H2A.Z.2: + $ref: + - "_terms_enum.yaml#/h2az2/common" + H2A.Z.2.2: + $ref: + - "_terms_enum.yaml#/h2az22/common" + H3.1: + $ref: + - "_terms_enum.yaml#/h31/common" + H3.2: + $ref: + - "_terms_enum.yaml#/h32/common" + H3.3: + $ref: + - "_terms_enum.yaml#/h33/common" + H3.5: + $ref: + - "_terms_enum.yaml#/h35/common" + H3.X: + $ref: + - "_terms_enum.yaml#/h3x/common" + H3.Y: + $ref: + - "_terms_enum.yaml#/h3y/common" + H3t (H3.4): + $ref: + - "_terms_enum.yaml#/h3t_h34/common" + mH2A: + $ref: + - "_terms_enum.yaml#/mh2a/common" + mH2A.1: + $ref: + - "_terms_enum.yaml#/mh2a1/common" + mH2A.2: + $ref: + - "_terms_enum.yaml#/mh2a2/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hpv_strain: + $ref: + - "_terms.yaml#/hpv_strain/common" + enum: + - HPV16 + - HPV18 + - HPV31 + - HPV33 + - HPV35 + - HPV39 + - HPV45 + - HPV51 + - HPV52 + - HPV56 + - HPV58 + - HPV59 + - HPV63 + - HPV66 + - HPV68 + - HPV70 + - HPV73 + - Unknown + - Not Reported + + intron: + $ref: + - "_terms.yaml#/intron/common" + type: string + pattern: "^(0|[1-9][0-9]{0,3})[a-z]?$" + + laboratory_test: + $ref: + - "_terms.yaml#/laboratory_test/common" + enum: + - 5-Hydroxyindoleacetic Acid + - Abnormal Cells + - Absolute Neutrophil + - Albumin + - Alpha Fetoprotein + - B-cell genotyping + - Basophil + - Beta 2 Microglobulin + - BG8 + - Blast Count + - Blood Urea Nitrogen + - C-Reactive Protein + - Calcium + - Cellularity + - Chromogranin A + - Chromogranin B + - Circulating Endothelial Cells + - Circulating Tumor Cells + - Creatinine + - Cytokeratin 5 + - Cytokeratin 6 + - Dopamine-Secreting + - Eosinophil + - Epinephrine-Secreting + - Epstein-Barr Virus + - Erythrocyte Sedimentation Rate + - Gamma-Enolase + - Glucose + - Hematocrit + - Hemoglobin + - HPV-E6/E7 + - Human Chorionic Gonadotropin + - Human Papillomavirus + - Immunoglobulin A + - Immunoglobulin G + - Immunoglobulin M + - Lactate Dehydrogenase + - Leukocytes + - Luteinizing Hormone + - Lymphoblasts + - Lymphocytes + - M Protein + - Metamyelocytes + - Metanephrine-Secreting + - Metaphase Nucleus Count + - Methoxytyramine-Secreting + - Microsatellite Instability + - Minimal Residual Disease + - Monocytes + - Myeloblasts + - Myelocytes + - Neutrophil Bands + - Norepinephrine-Secreting + - Normetanephrine-Secreting + - Platelets + - Prolymphocytes + - Promonocytes + - Promyelocytes + - Prothrombin Time + - Segmented Neutrophil + - Serum Free Immunoglobulin Light Chain, Kappa + - Serum Free Immunoglobulin Light Chain, Lambda + - Serum Free Immunoglobulin Light Chain, NOS + - Serum Mesothelin + - TAG-72 + - Testosterone + - Total Bilirubin + - Total Protein + - Unknown + - Not Reported + enumDef: + 5-Hydroxyindoleacetic Acid: + $ref: + - "_terms_enum.yaml#/5hydroxyindoleacetic_acid/common" + Absolute Neutrophil: + $ref: + - "_terms_enum.yaml#/absolute_neutrophil/common" + Albumin: + $ref: + - "_terms_enum.yaml#/albumin/common" + Alpha Fetoprotein: + $ref: + - "_terms_enum.yaml#/alpha_fetoprotein/common" + B-cell genotyping: + $ref: + - "_terms_enum.yaml#/bcell_genotyping/common" + Basophil: + $ref: + - "_terms_enum.yaml#/basophil/common" + Beta 2 Microglobulin: + $ref: + - "_terms_enum.yaml#/beta_2_microglobulin/common" + Blood Urea Nitrogen: + $ref: + - "_terms_enum.yaml#/blood_urea_nitrogen/common" + C-Reactive Protein: + $ref: + - "_terms_enum.yaml#/creactive_protein/common" + Calcium: + $ref: + - "_terms_enum.yaml#/calcium/common" + Cellularity: + $ref: + - "_terms_enum.yaml#/cellularity/common" + Chromogranin A: + $ref: + - "_terms_enum.yaml#/chromogranin_a/common" + Chromogranin B: + $ref: + - "_terms_enum.yaml#/chromogranin_b/common" + Circulating Tumor Cells: + $ref: + - "_terms_enum.yaml#/circulating_tumor_cells/common" + Creatinine: + $ref: + - "_terms_enum.yaml#/creatinine/common" + Eosinophil: + $ref: + - "_terms_enum.yaml#/eosinophil/common" + Epstein-Barr Virus: + $ref: + - "_terms_enum.yaml#/epsteinbarr_virus/common" + Gamma-Enolase: + $ref: + - "_terms_enum.yaml#/gammaenolase/common" + Glucose: + $ref: + - "_terms_enum.yaml#/glucose/common" + Hematocrit: + $ref: + - "_terms_enum.yaml#/hematocrit/common" + Hemoglobin: + $ref: + - "_terms_enum.yaml#/hemoglobin/common" + HPV-E6/E7: + $ref: + - "_terms_enum.yaml#/hpve6e7/common" + Human Chorionic Gonadotropin: + $ref: + - "_terms_enum.yaml#/human_chorionic_gonadotropin/common" + Human Papillomavirus: + $ref: + - "_terms_enum.yaml#/human_papillomavirus/common" + Immunoglobulin A: + $ref: + - "_terms_enum.yaml#/immunoglobulin_a/common" + Immunoglobulin G: + $ref: + - "_terms_enum.yaml#/immunoglobulin_g/common" + Immunoglobulin M: + $ref: + - "_terms_enum.yaml#/immunoglobulin_m/common" + Lactate Dehydrogenase: + $ref: + - "_terms_enum.yaml#/lactate_dehydrogenase/common" + Leukocytes: + $ref: + - "_terms_enum.yaml#/leukocytes/common" + Luteinizing Hormone: + $ref: + - "_terms_enum.yaml#/luteinizing_hormone/common" + Lymphoblasts: + $ref: + - "_terms_enum.yaml#/lymphoblasts/common" + Lymphocytes: + $ref: + - "_terms_enum.yaml#/lymphocytes/common" + M Protein: + $ref: + - "_terms_enum.yaml#/m_protein/common" + Metamyelocytes: + $ref: + - "_terms_enum.yaml#/metamyelocytes/common" + Myeloblasts: + $ref: + - "_terms_enum.yaml#/myeloblasts/common" + Myelocytes: + $ref: + - "_terms_enum.yaml#/myelocytes/common" + Neutrophil Bands: + $ref: + - "_terms_enum.yaml#/neutrophil_bands/common" + Platelets: + $ref: + - "_terms_enum.yaml#/platelets/common" + Prolymphocytes: + $ref: + - "_terms_enum.yaml#/prolymphocytes/common" + Promonocytes: + $ref: + - "_terms_enum.yaml#/promonocytes/common" + Promyelocytes: + $ref: + - "_terms_enum.yaml#/promyelocytes/common" + Segmented Neutrophil: + $ref: + - "_terms_enum.yaml#/segmented_neutrophil/common" + Serum Free Immunoglobulin Light Chain, Kappa: + $ref: + - "_terms_enum.yaml#/serum_free_immunoglobulin_light_chain_kappa/common" + Serum Free Immunoglobulin Light Chain, Lambda: + $ref: + - "_terms_enum.yaml#/serum_free_immunoglobulin_light_chain_lambda/common" + Serum Free Immunoglobulin Light Chain, NOS: + $ref: + - "_terms_enum.yaml#/serum_free_immunoglobulin_light_chain_nos/common" + Testosterone: + $ref: + - "_terms_enum.yaml#/testosterone/common" + Total Bilirubin: + $ref: + - "_terms_enum.yaml#/total_bilirubin/common" + Total Protein: + $ref: + - "_terms_enum.yaml#/total_protein/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + loci_abnormal_count: + $ref: + - "_terms.yaml#/loci_abnormal_count/common" + type: integer + minimum: 0 + + loci_count: + $ref: + - "_terms.yaml#/loci_count/common" + type: integer + minimum: 0 + + locus: + $ref: + - "_terms.yaml#/locus/common" + type: string + pattern: "^(AC_|NC_|NG_|NT_|NW_|NZ_b|NM_|NR_|XM_c|XR_c|AP_|NP_|YP_c|XP_c|WP_)[0-9]+(\\.(0|[1-9][0-9]{0,3}))?$" + + mismatch_repair_mutation: + $ref: + - "_terms.yaml#/mismatch_repair_mutation/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + mitotic_count: + $ref: + - "_terms.yaml#/mitotic_count/common" + type: number + minimum: 0 + + mitotic_total_area: + $ref: + - "_terms.yaml#/mitotic_total_area/common" + type: number + minimum: 0 + + molecular_analysis_method: + $ref: + - "_terms.yaml#/molecular_analysis_method/common" + enum: + - Comparative Genomic Hybridization + - Cytogenetics, NOS + - FISH + - Flow Cytometry + - IHC + - Immunofluorescence + - Immunophenotyping, NOS + - ISH + - Karyotype + - Microarray + - Microsatellite Analysis + - Microscopy, NOS + - Nuclear Staining + - PCR + - RNA Sequencing + - RT-PCR + - Sequencing, NOS + - Southern Blotting + - Targeted Sequencing + - WGS + - WXS + - Other + - Unknown + - Not Reported + enumDef: + Comparative Genomic Hybridization: + $ref: + - "_terms_enum.yaml#/comparative_genomic_hybridization/common" + Cytogenetics, NOS: + $ref: + - "_terms_enum.yaml#/cytogenetics_nos/common" + FISH: + $ref: + - "_terms_enum.yaml#/fish/common" + Flow Cytometry: + $ref: + - "_terms_enum.yaml#/flow_cytometry/common" + IHC: + $ref: + - "_terms_enum.yaml#/ihc/common" + Immunofluorescence: + $ref: + - "_terms_enum.yaml#/immunofluorescence/common" + ISH: + $ref: + - "_terms_enum.yaml#/ish/common" + Karyotype: + $ref: + - "_terms_enum.yaml#/karyotype/common" + Microarray: + $ref: + - "_terms_enum.yaml#/microarray/common" + Microsatellite Analysis: + $ref: + - "_terms_enum.yaml#/microsatellite_analysis/common" + Microscopy, NOS: + $ref: + - "_terms_enum.yaml#/microscopy_nos/common" + Nuclear Staining: + $ref: + - "_terms_enum.yaml#/nuclear_staining/common" + PCR: + $ref: + - "_terms_enum.yaml#/pcr/common" + RNA Sequencing: + $ref: + - "_terms_enum.yaml#/rna_sequencing/common" + RT-PCR: + $ref: + - "_terms_enum.yaml#/rtpcr/common" + Sequencing, NOS: + $ref: + - "_terms_enum.yaml#/sequencing_nos/common" + Southern Blotting: + $ref: + - "_terms_enum.yaml#/southern_blotting/common" + Targeted Sequencing: + $ref: + - "_terms_enum.yaml#/targeted_sequencing/common" + WGS: + $ref: + - "_terms_enum.yaml#/wgs/common" + WXS: + $ref: + - "_terms_enum.yaml#/wxs/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + molecular_consequence: + $ref: + - "_terms.yaml#/molecular_consequence/common" + enum: + - 3 Prime UTR Variant + - 5 Prime UTR Variant + - Coding Sequence Variant + - Downstream Gene Variant + - Exon Variant + - Feature Elongation + - Feature Truncation + - Frameshift Variant + - Incomplete Terminal Codon Variant + - Inframe Deletion + - Inframe Insertion + - Intergenic Variant + - Intron Variant + - Mature miRNA Variant + - Missense Variant + - NMD Transcript Variant + - Non-coding Transcript Exon Variant + - Non-coding Transcript Variant + - Nonsense + - Protein Altering Variant + - Regulatory Region Ablation + - Regulatory Region Amplification + - Regulatory Region Variant + - Splice Acceptor Variant + - Splice Donor Variant + - Splice Region Variant + - Start Lost + - Stop Gain + - Stop Lost + - Stop Retained Variant + - Synonymous Variant + - TF Binding Site Variant + - TFBS Ablation + - TFBS Amplification + - Transcript Ablation + - Transcript Amplification + - Upstream Gene Variant + - Unknown + - Not Reported + enumDef: + 3 Prime UTR Variant: + $ref: + - "_terms_enum.yaml#/3_prime_utr_variant/common" + 5 Prime UTR Variant: + $ref: + - "_terms_enum.yaml#/5_prime_utr_variant/common" + Coding Sequence Variant: + $ref: + - "_terms_enum.yaml#/coding_sequence_variant/common" + Downstream Gene Variant: + $ref: + - "_terms_enum.yaml#/downstream_gene_variant/common" + Feature Elongation: + $ref: + - "_terms_enum.yaml#/feature_elongation/common" + Feature Truncation: + $ref: + - "_terms_enum.yaml#/feature_truncation/common" + Frameshift Variant: + $ref: + - "_terms_enum.yaml#/frameshift_variant/common" + Inframe Deletion: + $ref: + - "_terms_enum.yaml#/inframe_deletion/common" + Inframe Insertion: + $ref: + - "_terms_enum.yaml#/inframe_insertion/common" + Intergenic Variant: + $ref: + - "_terms_enum.yaml#/intergenic_variant/common" + Intron Variant: + $ref: + - "_terms_enum.yaml#/intron_variant/common" + Mature miRNA Variant: + $ref: + - "_terms_enum.yaml#/mature_mirna_variant/common" + Missense Variant: + $ref: + - "_terms_enum.yaml#/missense_variant/common" + NMD Transcript Variant: + $ref: + - "_terms_enum.yaml#/nmd_transcript_variant/common" + Non-coding Transcript Exon Variant: + $ref: + - "_terms_enum.yaml#/noncoding_transcript_exon_variant/common" + Non-coding Transcript Variant: + $ref: + - "_terms_enum.yaml#/noncoding_transcript_variant/common" + Nonsense: + $ref: + - "_terms_enum.yaml#/nonsense/common" + Protein Altering Variant: + $ref: + - "_terms_enum.yaml#/protein_altering_variant/common" + Regulatory Region Ablation: + $ref: + - "_terms_enum.yaml#/regulatory_region_ablation/common" + Regulatory Region Amplification: + $ref: + - "_terms_enum.yaml#/regulatory_region_amplification/common" + Regulatory Region Variant: + $ref: + - "_terms_enum.yaml#/regulatory_region_variant/common" + Splice Acceptor Variant: + $ref: + - "_terms_enum.yaml#/splice_acceptor_variant/common" + Splice Donor Variant: + $ref: + - "_terms_enum.yaml#/splice_donor_variant/common" + Splice Region Variant: + $ref: + - "_terms_enum.yaml#/splice_region_variant/common" + Start Lost: + $ref: + - "_terms_enum.yaml#/start_lost/common" + Stop Gain: + $ref: + - "_terms_enum.yaml#/stop_gain/common" + Stop Lost: + $ref: + - "_terms_enum.yaml#/stop_lost/common" + Stop Retained Variant: + $ref: + - "_terms_enum.yaml#/stop_retained_variant/common" + Synonymous Variant: + $ref: + - "_terms_enum.yaml#/synonymous_variant/common" + TF Binding Site Variant: + $ref: + - "_terms_enum.yaml#/tf_binding_site_variant/common" + TFBS Ablation: + $ref: + - "_terms_enum.yaml#/tfbs_ablation/common" + TFBS Amplification: + $ref: + - "_terms_enum.yaml#/tfbs_amplification/common" + Transcript Ablation: + $ref: + - "_terms_enum.yaml#/transcript_ablation/common" + Transcript Amplification: + $ref: + - "_terms_enum.yaml#/transcript_amplification/common" + Upstream Gene Variant: + $ref: + - "_terms_enum.yaml#/upstream_gene_variant/common" + + mutation_codon: + $ref: + - "_terms.yaml#/mutation_codon/common" + enum: + - "12" + - "13" + - "61" + - Unknown + - Not Reported + + pathogenicity: + $ref: + - "_terms.yaml#/pathogenicity/common" + enum: + - Benign + - Likely Benign + - Likely Pathogenic + - Pathogenic + - Uncertain Significance + - Unknown + - Not Reported + enumDef: + Benign: + $ref: + - "_terms_enum.yaml#/benign/common" + Likely Benign: + $ref: + - "_terms_enum.yaml#/likely_benign/common" + Likely Pathogenic: + $ref: + - "_terms_enum.yaml#/likely_pathogenic/common" + Pathogenic: + $ref: + - "_terms_enum.yaml#/pathogenic/common" + Uncertain Significance: + $ref: + - "_terms_enum.yaml#/uncertain_significance/common" + + ploidy: + $ref: + - "_terms.yaml#/ploidy/common" + enum: + - Aneuploid + - Diploid + - Hyperdiploid + - Hypodiploid + - Near Diploid + - Tetraploid + - Unknown + - Not Reported + enumDef: + Aneuploid: + $ref: + - "_terms_enum.yaml#/aneuploid/common" + Diploid: + $ref: + - "_terms_enum.yaml#/diploid/common" + Hyperdiploid: + $ref: + - "_terms_enum.yaml#/hyperdiploid/common" + Hypodiploid: + $ref: + - "_terms_enum.yaml#/hypodiploid/common" + Near Diploid: + $ref: + - "_terms_enum.yaml#/near_diploid/common" + Tetraploid: + $ref: + - "_terms_enum.yaml#/tetraploid/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + second_exon: + $ref: + - "_terms.yaml#/second_exon/common" + type: string + pattern: "^(0|[1-9][0-9]{0,3})[a-z]?$" + + second_gene_symbol: + $ref: + - "_terms.yaml#/second_gene_symbol/common" + enum: + - A1CF + - ABI1 + - ABL1 + - ABL2 + - ACACA + - ACKR3 + - ACSL3 + - ACSL6 + - ACVR1 + - ACVR2A + - AFF1 + - AFF3 + - AFF4 + - AKAP9 + - AKT1 + - AKT2 + - AKT3 + - ALDH2 + - ALK + - AMER1 + - ANK1 + - APC + - APOBEC3B + - AR + - ARAF + - ARHGAP5 + - ARHGAP26 + - ARHGEF12 + - ARID1A + - ARID1B + - ARID2 + - ARNT + - ASPSCR1 + - ASXL1 + - ASXL2 + - ATF1 + - ATIC + - ATM + - ATP1A1 + - ATP2B3 + - ATR + - ATRX + - AXIN1 + - AXIN2 + - B2M + - BAP1 + - BARD1 + - BCL2 + - BCL2L12 + - BCL3 + - BCL6 + - BCL7A + - BCL9 + - BCL9L + - BCL10 + - BCL11A + - BCL11B + - BCLAF1 + - BCOR + - BCORL1 + - BCR + - BIRC3 + - BIRC6 + - BLM + - BMP5 + - BMPR1A + - BRAF + - BRCA1 + - BRCA2 + - BRD1 + - BRD3 + - BRD4 + - BRIP1 + - BTBD18 + - BTG1 + - BTK + - BUB1B + - C15orf65 + - CACNA1D + - CALR + - CAMTA1 + - CANT1 + - CARD11 + - CARS + - CASP8 + - CBFA2T2 + - CBFA2T3 + - CBFB + - CBL + - CBLB + - CBLC + - CCDC6 + - CCNB1IP1 + - CCNC + - CCND1 + - CCND2 + - CCND3 + - CCNE1 + - CCR4 + - CCR7 + - CD28 + - CD74 + - CD79A + - CD79B + - CD99 + - CD209 + - CD274 + - CDC73 + - CDH1 + - CDH10 + - CDH11 + - CDH17 + - CDK4 + - CDK6 + - CDK12 + - CDKN1A + - CDKN1B + - CDKN2A + - CDKN2C + - CDX2 + - CEBPA + - CEP89 + - CEP164 + - CEP170B + - CHCHD7 + - CHD2 + - CHD4 + - CHEK2 + - CHGA + - CHIC2 + - CHST11 + - CIC + - CIITA + - CLIP1 + - CLP1 + - CLTC + - CLTCL1 + - CNBD1 + - CNBP + - CNOT3 + - CNTNAP2 + - CNTRL + - COL1A1 + - COL2A1 + - COL3A1 + - COX6C + - CREB1 + - CREB3L1 + - CREB3L2 + - CREBBP + - CRLF2 + - CRNKL1 + - CRTC1 + - CRTC3 + - CSF1R + - CSF3R + - CSMD3 + - CTCF + - CTDP1 + - CTNNA2 + - CTNNB1 + - CTNND1 + - CTNND2 + - CUL3 + - CUX1 + - CXCR4 + - CYLD + - CYP2C8 + - CYSLTR2 + - DAXX + - DCAF12L2 + - DCC + - DCTN1 + - DDB2 + - DDIT3 + - DDR2 + - DDX3X + - DDX5 + - DDX6 + - DDX10 + - DEK + - DGCR8 + - DICER1 + - DNAJB1 + - DNM2 + - DNMT3A + - DOT1L + - DROSHA + - DUX4L1 + - EBF1 + - ECT2L + - EED + - EGFR + - EIF1AX + - EIF3E + - EIF4A2 + - ELF3 + - ELF4 + - ELK4 + - ELL + - ELN + - EML4 + - EP300 + - EPAS1 + - EPHA3 + - EPHA7 + - EPS15 + - ERBB2 + - ERBB3 + - ERBB4 + - ERC1 + - ERCC2 + - ERCC3 + - ERCC4 + - ERCC5 + - ERG + - ESR1 + - ETNK1 + - ETV1 + - ETV4 + - ETV5 + - ETV6 + - EWSR1 + - EXT1 + - EXT2 + - EZH2 + - EZR + - FAM46C + - FAM47C + - FAM131B + - FAM135B + - FANCA + - FANCC + - FANCD2 + - FANCE + - FANCF + - FANCG + - FAS + - FAT1 + - FAT3 + - FAT4 + - FBLN2 + - FBXO11 + - FBXW7 + - FCGR2B + - FCRL4 + - FEN1 + - FES + - FEV + - FGFR1 + - FGFR1OP + - FGFR2 + - FGFR3 + - FGFR4 + - FH + - FHIT + - FIP1L1 + - FKBP9 + - FLCN + - FLI1 + - FLNA + - FLT3 + - FLT4 + - FNBP1 + - FOXA1 + - FOXL2 + - FOXO1 + - FOXO3 + - FOXO4 + - FOXP1 + - FOXR1 + - FRYL + - FSTL3 + - FUBP1 + - FUS + - GAS7 + - GATA1 + - GATA2 + - GATA3 + - GLI1 + - GLIS2 + - GMPS + - GNA11 + - GNAQ + - GNAS + - GOLGA5 + - GOPC + - GPC3 + - GPHN + - GRIN2A + - GRM3 + - H3F3A + - H3F3B + - HERPUD1 + - HEY1 + - HIF1A + - HIP1 + - HIST1H3B + - HIST1H4I + - HLA-A + - HLF + - HMGA1 + - HMGA2 + - HMGB3 + - HMGN2P46 + - HNF1A + - HNRNPA2B1 + - HNRNPH1 + - HOOK3 + - HOXA9 + - HOXA11 + - HOXA13 + - HOXB1 + - HOXC11 + - HOXC13 + - HOXD11 + - HOXD13 + - HRAS + - HSP90AA1 + - HSP90AB1 + - ID3 + - IDH1 + - IDH2 + - IGH + - IGK + - IGL + - IKBKB + - IKZF1 + - IL2 + - IL6ST + - IL7R + - IL21R + - INO80D + - IRF4 + - IRS4 + - ISX + - ITGAV + - ITK + - JAK1 + - JAK2 + - JAK3 + - JARID2 + - JAZF1 + - JUN + - KAT6A + - KAT6B + - KAT7 + - KCNJ5 + - KDM5A + - KDM5C + - KDM6A + - KDR + - KDSR + - KEAP1 + - KIAA1549 + - KIF5B + - KIT + - KLF4 + - KLF6 + - KLK2 + - KMT2A + - KMT2C + - KMT2D + - KNL1 + - KNSTRN + - KRAS + - KTN1 + - LARP4B + - LASP1 + - LCK + - LCP1 + - LEF1 + - LHFP + - LIFR + - LMNA + - LMO1 + - LMO2 + - LPP + - LRIG3 + - LRP1B + - LSM14A + - LYL1 + - LZTR1 + - MAF + - MAFB + - MALAT1 + - MALT1 + - MAML2 + - MAML3 + - MAP2K1 + - MAP2K2 + - MAP2K4 + - MAP3K1 + - MAP3K13 + - MAPK1 + - MAX + - MB21D2 + - MDM2 + - MDM4 + - MDS2 + - MECOM + - MED12 + - MEN1 + - MET + - MGMT + - MITF + - MKL1 + - MLF1 + - MLH1 + - MLH2 + - MLLT1 + - MLLT3 + - MLLT4 + - MLLT6 + - MLLT10 + - MLLT11 + - MN1 + - MNX1 + - MPL + - MPO + - MSH2 + - MSH6 + - MSI2 + - MSN + - MTCP1 + - MTOR + - MUC1 + - MUC4 + - MUC16 + - MUTYH + - MYB + - MYC + - MYCL + - MYCN + - MYD88 + - MYH9 + - MYH11 + - MYO5A + - MYOD1 + - NAB2 + - NACA + - NBEA + - NBN + - NCKIPSD + - NCOA1 + - NCOA2 + - NCOA4 + - NCOR1 + - NCOR2 + - NDRG1 + - NF1 + - NF2 + - NFATC2 + - NFE2L2 + - NFIB + - NFKB2 + - NFKBIE + - NIN + - NKX2-1 + - NONO + - NOTCH1 + - NOTCH2 + - NPM1 + - NR4A3 + - NRAS + - NRG1 + - NSD1 + - NSD2 + - NSD3 + - NT5C2 + - NTHL1 + - NTRK1 + - NTRK3 + - NUMA1 + - NUP98 + - NUP214 + - NUTM1 + - NUTM2A + - NUTM2B + - OLIG2 + - OMD + - P2RY8 + - PABPC1 + - PAFAH1B2 + - PALB2 + - PATZ1 + - PAX3 + - PAX5 + - PAX7 + - PAX8 + - PBRM1 + - PBX1 + - PCBP1 + - PCM1 + - PDCD1LG2 + - PDE4DIP + - PDGFB + - PDGFRA + - PDGFRB + - PER1 + - PGR + - PHF6 + - PHF23 + - PHOX2B + - PICALM + - PIK3CA + - PIK3CB + - PIK3R1 + - PIM1 + - PIM3 + - PLAG1 + - PLCG1 + - PML + - PMS1 + - PMS2 + - POLD1 + - POLE + - POLG + - POLQ + - POT1 + - POU2AF1 + - POU5F1 + - PPARG + - PPFIBP1 + - PPM1D + - PPP2R1A + - PPP6C + - PRCC + - PRDM1 + - PRDM2 + - PRDM16 + - PREX2 + - PRF1 + - PRKACA + - PRKAR1A + - PRKCB + - PRPF40B + - PRRX1 + - PSIP1 + - PTCH1 + - PTEN + - PTK6 + - PTP4A1 + - PTPN6 + - PTPN11 + - PTPN13 + - PTPRB + - PTPRC + - PTPRK + - PTPRT + - PWWP2A + - QKI + - RABEP1 + - RAC1 + - RAD21 + - RAD51B + - RAF1 + - RALGDS + - RANBP2 + - RAP1GDS1 + - RARA + - RAS, NOS + - RB1 + - RBM10 + - RBM15 + - RECQL4 + - REL + - RET + - RGPD3 + - RGS7 + - RHOA + - RHOH + - RMI2 + - RNF43 + - RNF213 + - ROBO2 + - ROS1 + - RPL5 + - RPL10 + - RPL22 + - RPN1 + - RPS15 + - RSPO2 + - RSPO3 + - RUNX1 + - RUNX1T1 + - S100A7 + - SALL4 + - SBDS + - SDC4 + - SDHA + - SDHAF2 + - SDHB + - SDHC + - SDHD + - SEPT5 + - SEPT6 + - SEPT9 + - SET + - SETBP1 + - SETD1A + - SETD2 + - SF3B1 + - SFPQ + - SFRP4 + - SGK1 + - SH2B3 + - SH3GL1 + - SHTN1 + - SIRPA + - SKI + - SLC34A2 + - SLC45A3 + - SLC66A2 (aka PQLC1) + - SMAD2 + - SMAD3 + - SMAD4 + - SMARCA4 + - SMARCB1 + - SMARCD1 + - SMARCE1 + - SMC1A + - SMO + - SND1 + - SNX29 + - SOCS1 + - SOX2 + - SPECC1 + - SPEN + - SPOP + - SRC + - SRGAP3 + - SRSF2 + - SRSF3 + - SS18 + - SS18L1 + - SSX1 + - SSX2 + - SSX4 + - STAG1 + - STAG2 + - STAT3 + - STAT5B + - STAT6 + - STIL + - STK11 + - STRN + - SUFU + - SUZ12 + - SYK + - SYP + - TAF15 + - TAL1 + - TAL2 + - TBL1XR1 + - TBX3 + - TCEA1 + - TCF3 + - TCF7L2 + - TCF12 + - TCL1A + - TEC + - TERT + - TET1 + - TET2 + - TFE3 + - TFEB + - TFG + - TFPT + - TFRC + - TGFBR2 + - THRAP3 + - TLR2 + - TLX1 + - TLX3 + - TMEM127 + - TMPRSS2 + - TNC + - TNFAIP3 + - TNFRSF14 + - TNFRSF17 + - TOP1 + - TOP2B + - TP53 + - TP63 + - TPM3 + - TPM4 + - TPR + - TRA + - TRAF7 + - TRB + - TRD + - TRIM24 + - TRIM27 + - TRIM33 + - TRIP11 + - TRRAP + - TSC1 + - TSC2 + - TSHR + - U2AF1 + - UBB + - UBR5 + - USP6 + - USP8 + - VAV1 + - VHL + - VTI1A + - WAS + - WDCP + - WIF1 + - WNK2 + - WRN + - WT1 + - WWTR1 + - XPA + - XPC + - XPO1 + - YWHAE + - ZBTB16 + - ZCCHC8 + - ZEB1 + - ZEB2 + - ZFHX3 + - ZMYM3 + - ZNF198 + - ZNF331 + - ZNF384 + - ZNF429 + - ZNF444 + - ZNF479 + - ZNF521 + - ZNRF3 + - ZRSR2 + - Unknown + - Not Reported + enumDef: + A1CF: + $ref: + - "_terms_enum.yaml#/a1cf/common" + ABI1: + $ref: + - "_terms_enum.yaml#/abi1/common" + ABL1: + $ref: + - "_terms_enum.yaml#/abl1/common" + ABL2: + $ref: + - "_terms_enum.yaml#/abl2/common" + ACACA: + $ref: + - "_terms_enum.yaml#/acaca/common" + ACKR3: + $ref: + - "_terms_enum.yaml#/ackr3/common" + ACSL3: + $ref: + - "_terms_enum.yaml#/acsl3/common" + ACSL6: + $ref: + - "_terms_enum.yaml#/acsl6/common" + ACVR1: + $ref: + - "_terms_enum.yaml#/acvr1/common" + ACVR2A: + $ref: + - "_terms_enum.yaml#/acvr2a/common" + AFF1: + $ref: + - "_terms_enum.yaml#/aff1/common" + AFF3: + $ref: + - "_terms_enum.yaml#/aff3/common" + AFF4: + $ref: + - "_terms_enum.yaml#/aff4/common" + AKAP9: + $ref: + - "_terms_enum.yaml#/akap9/common" + AKT1: + $ref: + - "_terms_enum.yaml#/akt1/common" + AKT2: + $ref: + - "_terms_enum.yaml#/akt2/common" + AKT3: + $ref: + - "_terms_enum.yaml#/akt3/common" + ALDH2: + $ref: + - "_terms_enum.yaml#/aldh2/common" + ALK: + $ref: + - "_terms_enum.yaml#/alk/common" + AMER1: + $ref: + - "_terms_enum.yaml#/amer1/common" + ANK1: + $ref: + - "_terms_enum.yaml#/ank1/common" + APC: + $ref: + - "_terms_enum.yaml#/apc/common" + APOBEC3B: + $ref: + - "_terms_enum.yaml#/apobec3b/common" + AR: + $ref: + - "_terms_enum.yaml#/ar/common" + ARAF: + $ref: + - "_terms_enum.yaml#/araf/common" + ARHGAP5: + $ref: + - "_terms_enum.yaml#/arhgap5/common" + ARHGAP26: + $ref: + - "_terms_enum.yaml#/arhgap26/common" + ARHGEF12: + $ref: + - "_terms_enum.yaml#/arhgef12/common" + ARID1A: + $ref: + - "_terms_enum.yaml#/arid1a/common" + ARID1B: + $ref: + - "_terms_enum.yaml#/arid1b/common" + ARID2: + $ref: + - "_terms_enum.yaml#/arid2/common" + ARNT: + $ref: + - "_terms_enum.yaml#/arnt/common" + ASPSCR1: + $ref: + - "_terms_enum.yaml#/aspscr1/common" + ASXL1: + $ref: + - "_terms_enum.yaml#/asxl1/common" + ASXL2: + $ref: + - "_terms_enum.yaml#/asxl2/common" + ATF1: + $ref: + - "_terms_enum.yaml#/atf1/common" + ATIC: + $ref: + - "_terms_enum.yaml#/atic/common" + ATM: + $ref: + - "_terms_enum.yaml#/atm/common" + ATP1A1: + $ref: + - "_terms_enum.yaml#/atp1a1/common" + ATP2B3: + $ref: + - "_terms_enum.yaml#/atp2b3/common" + ATR: + $ref: + - "_terms_enum.yaml#/atr/common" + ATRX: + $ref: + - "_terms_enum.yaml#/atrx/common" + AXIN1: + $ref: + - "_terms_enum.yaml#/axin1/common" + AXIN2: + $ref: + - "_terms_enum.yaml#/axin2/common" + B2M: + $ref: + - "_terms_enum.yaml#/b2m/common" + BAP1: + $ref: + - "_terms_enum.yaml#/bap1/common" + BARD1: + $ref: + - "_terms_enum.yaml#/bard1/common" + BCL2: + $ref: + - "_terms_enum.yaml#/bcl2/common" + BCL2L12: + $ref: + - "_terms_enum.yaml#/bcl2l12/common" + BCL3: + $ref: + - "_terms_enum.yaml#/bcl3/common" + BCL6: + $ref: + - "_terms_enum.yaml#/bcl6/common" + BCL7A: + $ref: + - "_terms_enum.yaml#/bcl7a/common" + BCL9: + $ref: + - "_terms_enum.yaml#/bcl9/common" + BCL9L: + $ref: + - "_terms_enum.yaml#/bcl9l/common" + BCL10: + $ref: + - "_terms_enum.yaml#/bcl10/common" + BCL11A: + $ref: + - "_terms_enum.yaml#/bcl11a/common" + BCL11B: + $ref: + - "_terms_enum.yaml#/bcl11b/common" + BCLAF1: + $ref: + - "_terms_enum.yaml#/bclaf1/common" + BCOR: + $ref: + - "_terms_enum.yaml#/bcor/common" + BCORL1: + $ref: + - "_terms_enum.yaml#/bcorl1/common" + BCR: + $ref: + - "_terms_enum.yaml#/bcr/common" + BIRC3: + $ref: + - "_terms_enum.yaml#/birc3/common" + BIRC6: + $ref: + - "_terms_enum.yaml#/birc6/common" + BLM: + $ref: + - "_terms_enum.yaml#/blm/common" + BMP5: + $ref: + - "_terms_enum.yaml#/bmp5/common" + BMPR1A: + $ref: + - "_terms_enum.yaml#/bmpr1a/common" + BRAF: + $ref: + - "_terms_enum.yaml#/braf/common" + BRCA1: + $ref: + - "_terms_enum.yaml#/brca1/common" + BRCA2: + $ref: + - "_terms_enum.yaml#/brca2/common" + BRD1: + $ref: + - "_terms_enum.yaml#/brd1/common" + BRD3: + $ref: + - "_terms_enum.yaml#/brd3/common" + BRD4: + $ref: + - "_terms_enum.yaml#/brd4/common" + BRIP1: + $ref: + - "_terms_enum.yaml#/brip1/common" + BTBD18: + $ref: + - "_terms_enum.yaml#/btbd18/common" + BTG1: + $ref: + - "_terms_enum.yaml#/btg1/common" + BTK: + $ref: + - "_terms_enum.yaml#/btk/common" + BUB1B: + $ref: + - "_terms_enum.yaml#/bub1b/common" + C15orf65: + $ref: + - "_terms_enum.yaml#/c15orf65/common" + CACNA1D: + $ref: + - "_terms_enum.yaml#/cacna1d/common" + CALR: + $ref: + - "_terms_enum.yaml#/calr/common" + CAMTA1: + $ref: + - "_terms_enum.yaml#/camta1/common" + CANT1: + $ref: + - "_terms_enum.yaml#/cant1/common" + CARD11: + $ref: + - "_terms_enum.yaml#/card11/common" + CARS: + $ref: + - "_terms_enum.yaml#/cars/common" + CASP8: + $ref: + - "_terms_enum.yaml#/casp8/common" + CBFA2T2: + $ref: + - "_terms_enum.yaml#/cbfa2t2/common" + CBFA2T3: + $ref: + - "_terms_enum.yaml#/cbfa2t3/common" + CBFB: + $ref: + - "_terms_enum.yaml#/cbfb/common" + CBL: + $ref: + - "_terms_enum.yaml#/cbl/common" + CBLB: + $ref: + - "_terms_enum.yaml#/cblb/common" + CBLC: + $ref: + - "_terms_enum.yaml#/cblc/common" + CCDC6: + $ref: + - "_terms_enum.yaml#/ccdc6/common" + CCNB1IP1: + $ref: + - "_terms_enum.yaml#/ccnb1ip1/common" + CCNC: + $ref: + - "_terms_enum.yaml#/ccnc/common" + CCND1: + $ref: + - "_terms_enum.yaml#/ccnd1/common" + CCND2: + $ref: + - "_terms_enum.yaml#/ccnd2/common" + CCND3: + $ref: + - "_terms_enum.yaml#/ccnd3/common" + CCNE1: + $ref: + - "_terms_enum.yaml#/ccne1/common" + CCR4: + $ref: + - "_terms_enum.yaml#/ccr4/common" + CCR7: + $ref: + - "_terms_enum.yaml#/ccr7/common" + CD28: + $ref: + - "_terms_enum.yaml#/cd28/common" + CD74: + $ref: + - "_terms_enum.yaml#/cd74/common" + CD79A: + $ref: + - "_terms_enum.yaml#/cd79a/common" + CD79B: + $ref: + - "_terms_enum.yaml#/cd79b/common" + CD99: + $ref: + - "_terms_enum.yaml#/cd99/common" + CD209: + $ref: + - "_terms_enum.yaml#/cd209/common" + CD274: + $ref: + - "_terms_enum.yaml#/cd274/common" + CDC73: + $ref: + - "_terms_enum.yaml#/cdc73/common" + CDH1: + $ref: + - "_terms_enum.yaml#/cdh1/common" + CDH10: + $ref: + - "_terms_enum.yaml#/cdh10/common" + CDH11: + $ref: + - "_terms_enum.yaml#/cdh11/common" + CDH17: + $ref: + - "_terms_enum.yaml#/cdh17/common" + CDK4: + $ref: + - "_terms_enum.yaml#/cdk4/common" + CDK6: + $ref: + - "_terms_enum.yaml#/cdk6/common" + CDK12: + $ref: + - "_terms_enum.yaml#/cdk12/common" + CDKN1A: + $ref: + - "_terms_enum.yaml#/cdkn1a/common" + CDKN1B: + $ref: + - "_terms_enum.yaml#/cdkn1b/common" + CDKN2A: + $ref: + - "_terms_enum.yaml#/cdkn2a/common" + CDKN2C: + $ref: + - "_terms_enum.yaml#/cdkn2c/common" + CDX2: + $ref: + - "_terms_enum.yaml#/cdx2/common" + CEBPA: + $ref: + - "_terms_enum.yaml#/cebpa/common" + CEP89: + $ref: + - "_terms_enum.yaml#/cep89/common" + CEP170B: + $ref: + - "_terms_enum.yaml#/cep170b/common" + CHCHD7: + $ref: + - "_terms_enum.yaml#/chchd7/common" + CHD2: + $ref: + - "_terms_enum.yaml#/chd2/common" + CHD4: + $ref: + - "_terms_enum.yaml#/chd4/common" + CHEK2: + $ref: + - "_terms_enum.yaml#/chek2/common" + CHGA: + $ref: + - "_terms_enum.yaml#/chga/common" + CHIC2: + $ref: + - "_terms_enum.yaml#/chic2/common" + CHST11: + $ref: + - "_terms_enum.yaml#/chst11/common" + CIC: + $ref: + - "_terms_enum.yaml#/cic/common" + CIITA: + $ref: + - "_terms_enum.yaml#/ciita/common" + CLIP1: + $ref: + - "_terms_enum.yaml#/clip1/common" + CLP1: + $ref: + - "_terms_enum.yaml#/clp1/common" + CLTC: + $ref: + - "_terms_enum.yaml#/cltc/common" + CLTCL1: + $ref: + - "_terms_enum.yaml#/cltcl1/common" + CNBD1: + $ref: + - "_terms_enum.yaml#/cnbd1/common" + CNBP: + $ref: + - "_terms_enum.yaml#/cnbp/common" + CNOT3: + $ref: + - "_terms_enum.yaml#/cnot3/common" + CNTNAP2: + $ref: + - "_terms_enum.yaml#/cntnap2/common" + CNTRL: + $ref: + - "_terms_enum.yaml#/cntrl/common" + COL1A1: + $ref: + - "_terms_enum.yaml#/col1a1/common" + COL2A1: + $ref: + - "_terms_enum.yaml#/col2a1/common" + COL3A1: + $ref: + - "_terms_enum.yaml#/col3a1/common" + COX6C: + $ref: + - "_terms_enum.yaml#/cox6c/common" + CREB1: + $ref: + - "_terms_enum.yaml#/creb1/common" + CREB3L1: + $ref: + - "_terms_enum.yaml#/creb3l1/common" + CREB3L2: + $ref: + - "_terms_enum.yaml#/creb3l2/common" + CREBBP: + $ref: + - "_terms_enum.yaml#/crebbp/common" + CRLF2: + $ref: + - "_terms_enum.yaml#/crlf2/common" + CRNKL1: + $ref: + - "_terms_enum.yaml#/crnkl1/common" + CRTC1: + $ref: + - "_terms_enum.yaml#/crtc1/common" + CRTC3: + $ref: + - "_terms_enum.yaml#/crtc3/common" + CSF1R: + $ref: + - "_terms_enum.yaml#/csf1r/common" + CSF3R: + $ref: + - "_terms_enum.yaml#/csf3r/common" + CSMD3: + $ref: + - "_terms_enum.yaml#/csmd3/common" + CTCF: + $ref: + - "_terms_enum.yaml#/ctcf/common" + CTNNA2: + $ref: + - "_terms_enum.yaml#/ctnna2/common" + CTNNB1: + $ref: + - "_terms_enum.yaml#/ctnnb1/common" + CTNND1: + $ref: + - "_terms_enum.yaml#/ctnnd1/common" + CTNND2: + $ref: + - "_terms_enum.yaml#/ctnnd2/common" + CUL3: + $ref: + - "_terms_enum.yaml#/cul3/common" + CUX1: + $ref: + - "_terms_enum.yaml#/cux1/common" + CXCR4: + $ref: + - "_terms_enum.yaml#/cxcr4/common" + CYLD: + $ref: + - "_terms_enum.yaml#/cyld/common" + CYP2C8: + $ref: + - "_terms_enum.yaml#/cyp2c8/common" + CYSLTR2: + $ref: + - "_terms_enum.yaml#/cysltr2/common" + DAXX: + $ref: + - "_terms_enum.yaml#/daxx/common" + DCAF12L2: + $ref: + - "_terms_enum.yaml#/dcaf12l2/common" + DCC: + $ref: + - "_terms_enum.yaml#/dcc/common" + DCTN1: + $ref: + - "_terms_enum.yaml#/dctn1/common" + DDB2: + $ref: + - "_terms_enum.yaml#/ddb2/common" + DDIT3: + $ref: + - "_terms_enum.yaml#/ddit3/common" + DDR2: + $ref: + - "_terms_enum.yaml#/ddr2/common" + DDX3X: + $ref: + - "_terms_enum.yaml#/ddx3x/common" + DDX5: + $ref: + - "_terms_enum.yaml#/ddx5/common" + DDX6: + $ref: + - "_terms_enum.yaml#/ddx6/common" + DDX10: + $ref: + - "_terms_enum.yaml#/ddx10/common" + DEK: + $ref: + - "_terms_enum.yaml#/dek/common" + DGCR8: + $ref: + - "_terms_enum.yaml#/dgcr8/common" + DICER1: + $ref: + - "_terms_enum.yaml#/dicer1/common" + DNAJB1: + $ref: + - "_terms_enum.yaml#/dnajb1/common" + DNM2: + $ref: + - "_terms_enum.yaml#/dnm2/common" + DNMT3A: + $ref: + - "_terms_enum.yaml#/dnmt3a/common" + DOT1L: + $ref: + - "_terms_enum.yaml#/dot1l/common" + DROSHA: + $ref: + - "_terms_enum.yaml#/drosha/common" + DUX4L1: + $ref: + - "_terms_enum.yaml#/dux4l1/common" + EBF1: + $ref: + - "_terms_enum.yaml#/ebf1/common" + ECT2L: + $ref: + - "_terms_enum.yaml#/ect2l/common" + EED: + $ref: + - "_terms_enum.yaml#/eed/common" + EGFR: + $ref: + - "_terms_enum.yaml#/egfr/common" + EIF1AX: + $ref: + - "_terms_enum.yaml#/eif1ax/common" + EIF3E: + $ref: + - "_terms_enum.yaml#/eif3e/common" + EIF4A2: + $ref: + - "_terms_enum.yaml#/eif4a2/common" + ELF3: + $ref: + - "_terms_enum.yaml#/elf3/common" + ELF4: + $ref: + - "_terms_enum.yaml#/elf4/common" + ELK4: + $ref: + - "_terms_enum.yaml#/elk4/common" + ELL: + $ref: + - "_terms_enum.yaml#/ell/common" + ELN: + $ref: + - "_terms_enum.yaml#/eln/common" + EML4: + $ref: + - "_terms_enum.yaml#/eml4/common" + EP300: + $ref: + - "_terms_enum.yaml#/ep300/common" + EPAS1: + $ref: + - "_terms_enum.yaml#/epas1/common" + EPHA3: + $ref: + - "_terms_enum.yaml#/epha3/common" + EPHA7: + $ref: + - "_terms_enum.yaml#/epha7/common" + EPS15: + $ref: + - "_terms_enum.yaml#/eps15/common" + ERBB2: + $ref: + - "_terms_enum.yaml#/erbb2/common" + ERBB3: + $ref: + - "_terms_enum.yaml#/erbb3/common" + ERBB4: + $ref: + - "_terms_enum.yaml#/erbb4/common" + ERC1: + $ref: + - "_terms_enum.yaml#/erc1/common" + ERCC2: + $ref: + - "_terms_enum.yaml#/ercc2/common" + ERCC3: + $ref: + - "_terms_enum.yaml#/ercc3/common" + ERCC4: + $ref: + - "_terms_enum.yaml#/ercc4/common" + ERCC5: + $ref: + - "_terms_enum.yaml#/ercc5/common" + ERG: + $ref: + - "_terms_enum.yaml#/erg/common" + ESR1: + $ref: + - "_terms_enum.yaml#/esr1/common" + ETNK1: + $ref: + - "_terms_enum.yaml#/etnk1/common" + ETV1: + $ref: + - "_terms_enum.yaml#/etv1/common" + ETV4: + $ref: + - "_terms_enum.yaml#/etv4/common" + ETV5: + $ref: + - "_terms_enum.yaml#/etv5/common" + ETV6: + $ref: + - "_terms_enum.yaml#/etv6/common" + EWSR1: + $ref: + - "_terms_enum.yaml#/ewsr1/common" + EXT1: + $ref: + - "_terms_enum.yaml#/ext1/common" + EXT2: + $ref: + - "_terms_enum.yaml#/ext2/common" + EZH2: + $ref: + - "_terms_enum.yaml#/ezh2/common" + EZR: + $ref: + - "_terms_enum.yaml#/ezr/common" + FAM46C: + $ref: + - "_terms_enum.yaml#/fam46c/common" + FAM47C: + $ref: + - "_terms_enum.yaml#/fam47c/common" + FAM131B: + $ref: + - "_terms_enum.yaml#/fam131b/common" + FAM135B: + $ref: + - "_terms_enum.yaml#/fam135b/common" + FANCA: + $ref: + - "_terms_enum.yaml#/fanca/common" + FANCC: + $ref: + - "_terms_enum.yaml#/fancc/common" + FANCD2: + $ref: + - "_terms_enum.yaml#/fancd2/common" + FANCE: + $ref: + - "_terms_enum.yaml#/fance/common" + FANCF: + $ref: + - "_terms_enum.yaml#/fancf/common" + FANCG: + $ref: + - "_terms_enum.yaml#/fancg/common" + FAS: + $ref: + - "_terms_enum.yaml#/fas/common" + FAT1: + $ref: + - "_terms_enum.yaml#/fat1/common" + FAT3: + $ref: + - "_terms_enum.yaml#/fat3/common" + FAT4: + $ref: + - "_terms_enum.yaml#/fat4/common" + FBLN2: + $ref: + - "_terms_enum.yaml#/fbln2/common" + FBXO11: + $ref: + - "_terms_enum.yaml#/fbxo11/common" + FBXW7: + $ref: + - "_terms_enum.yaml#/fbxw7/common" + FCGR2B: + $ref: + - "_terms_enum.yaml#/fcgr2b/common" + FCRL4: + $ref: + - "_terms_enum.yaml#/fcrl4/common" + FEN1: + $ref: + - "_terms_enum.yaml#/fen1/common" + FES: + $ref: + - "_terms_enum.yaml#/fes/common" + FEV: + $ref: + - "_terms_enum.yaml#/fev/common" + FGFR1: + $ref: + - "_terms_enum.yaml#/fgfr1/common" + FGFR1OP: + $ref: + - "_terms_enum.yaml#/fgfr1op/common" + FGFR2: + $ref: + - "_terms_enum.yaml#/fgfr2/common" + FGFR3: + $ref: + - "_terms_enum.yaml#/fgfr3/common" + FGFR4: + $ref: + - "_terms_enum.yaml#/fgfr4/common" + FH: + $ref: + - "_terms_enum.yaml#/fh/common" + FHIT: + $ref: + - "_terms_enum.yaml#/fhit/common" + FIP1L1: + $ref: + - "_terms_enum.yaml#/fip1l1/common" + FKBP9: + $ref: + - "_terms_enum.yaml#/fkbp9/common" + FLCN: + $ref: + - "_terms_enum.yaml#/flcn/common" + FLI1: + $ref: + - "_terms_enum.yaml#/fli1/common" + FLNA: + $ref: + - "_terms_enum.yaml#/flna/common" + FLT3: + $ref: + - "_terms_enum.yaml#/flt3/common" + FLT4: + $ref: + - "_terms_enum.yaml#/flt4/common" + FNBP1: + $ref: + - "_terms_enum.yaml#/fnbp1/common" + FOXA1: + $ref: + - "_terms_enum.yaml#/foxa1/common" + FOXL2: + $ref: + - "_terms_enum.yaml#/foxl2/common" + FOXO1: + $ref: + - "_terms_enum.yaml#/foxo1/common" + FOXO3: + $ref: + - "_terms_enum.yaml#/foxo3/common" + FOXO4: + $ref: + - "_terms_enum.yaml#/foxo4/common" + FOXP1: + $ref: + - "_terms_enum.yaml#/foxp1/common" + FOXR1: + $ref: + - "_terms_enum.yaml#/foxr1/common" + FRYL: + $ref: + - "_terms_enum.yaml#/fryl/common" + FSTL3: + $ref: + - "_terms_enum.yaml#/fstl3/common" + FUBP1: + $ref: + - "_terms_enum.yaml#/fubp1/common" + FUS: + $ref: + - "_terms_enum.yaml#/fus/common" + GAS7: + $ref: + - "_terms_enum.yaml#/gas7/common" + GATA1: + $ref: + - "_terms_enum.yaml#/gata1/common" + GATA2: + $ref: + - "_terms_enum.yaml#/gata2/common" + GATA3: + $ref: + - "_terms_enum.yaml#/gata3/common" + GLI1: + $ref: + - "_terms_enum.yaml#/gli1/common" + GLIS2: + $ref: + - "_terms_enum.yaml#/glis2/common" + GMPS: + $ref: + - "_terms_enum.yaml#/gmps/common" + GNA11: + $ref: + - "_terms_enum.yaml#/gna11/common" + GNAQ: + $ref: + - "_terms_enum.yaml#/gnaq/common" + GNAS: + $ref: + - "_terms_enum.yaml#/gnas/common" + GOLGA5: + $ref: + - "_terms_enum.yaml#/golga5/common" + GOPC: + $ref: + - "_terms_enum.yaml#/gopc/common" + GPC3: + $ref: + - "_terms_enum.yaml#/gpc3/common" + GPHN: + $ref: + - "_terms_enum.yaml#/gphn/common" + GRIN2A: + $ref: + - "_terms_enum.yaml#/grin2a/common" + GRM3: + $ref: + - "_terms_enum.yaml#/grm3/common" + H3F3A: + $ref: + - "_terms_enum.yaml#/h3f3a/common" + H3F3B: + $ref: + - "_terms_enum.yaml#/h3f3b/common" + HERPUD1: + $ref: + - "_terms_enum.yaml#/herpud1/common" + HEY1: + $ref: + - "_terms_enum.yaml#/hey1/common" + HIF1A: + $ref: + - "_terms_enum.yaml#/hif1a/common" + HIP1: + $ref: + - "_terms_enum.yaml#/hip1/common" + HIST1H3B: + $ref: + - "_terms_enum.yaml#/hist1h3b/common" + HIST1H4I: + $ref: + - "_terms_enum.yaml#/hist1h4i/common" + HLA-A: + $ref: + - "_terms_enum.yaml#/hlaa/common" + HLF: + $ref: + - "_terms_enum.yaml#/hlf/common" + HMGA1: + $ref: + - "_terms_enum.yaml#/hmga1/common" + HMGA2: + $ref: + - "_terms_enum.yaml#/hmga2/common" + HMGB3: + $ref: + - "_terms_enum.yaml#/hmgb3/common" + HMGN2P46: + $ref: + - "_terms_enum.yaml#/hmgn2p46/common" + HNF1A: + $ref: + - "_terms_enum.yaml#/hnf1a/common" + HNRNPA2B1: + $ref: + - "_terms_enum.yaml#/hnrnpa2b1/common" + HOOK3: + $ref: + - "_terms_enum.yaml#/hook3/common" + HOXA9: + $ref: + - "_terms_enum.yaml#/hoxa9/common" + HOXA11: + $ref: + - "_terms_enum.yaml#/hoxa11/common" + HOXA13: + $ref: + - "_terms_enum.yaml#/hoxa13/common" + HOXB1: + $ref: + - "_terms_enum.yaml#/hoxb1/common" + HOXC11: + $ref: + - "_terms_enum.yaml#/hoxc11/common" + HOXC13: + $ref: + - "_terms_enum.yaml#/hoxc13/common" + HOXD11: + $ref: + - "_terms_enum.yaml#/hoxd11/common" + HOXD13: + $ref: + - "_terms_enum.yaml#/hoxd13/common" + HRAS: + $ref: + - "_terms_enum.yaml#/hras/common" + HSP90AA1: + $ref: + - "_terms_enum.yaml#/hsp90aa1/common" + HSP90AB1: + $ref: + - "_terms_enum.yaml#/hsp90ab1/common" + ID3: + $ref: + - "_terms_enum.yaml#/id3/common" + IDH1: + $ref: + - "_terms_enum.yaml#/idh1/common" + IDH2: + $ref: + - "_terms_enum.yaml#/idh2/common" + IGH: + $ref: + - "_terms_enum.yaml#/igh/common" + IGK: + $ref: + - "_terms_enum.yaml#/igk/common" + IGL: + $ref: + - "_terms_enum.yaml#/igl/common" + IKBKB: + $ref: + - "_terms_enum.yaml#/ikbkb/common" + IKZF1: + $ref: + - "_terms_enum.yaml#/ikzf1/common" + IL2: + $ref: + - "_terms_enum.yaml#/il2/common" + IL6ST: + $ref: + - "_terms_enum.yaml#/il6st/common" + IL7R: + $ref: + - "_terms_enum.yaml#/il7r/common" + IL21R: + $ref: + - "_terms_enum.yaml#/il21r/common" + INO80D: + $ref: + - "_terms_enum.yaml#/ino80d/common" + IRF4: + $ref: + - "_terms_enum.yaml#/irf4/common" + IRS4: + $ref: + - "_terms_enum.yaml#/irs4/common" + ISX: + $ref: + - "_terms_enum.yaml#/isx/common" + ITGAV: + $ref: + - "_terms_enum.yaml#/itgav/common" + ITK: + $ref: + - "_terms_enum.yaml#/itk/common" + JAK1: + $ref: + - "_terms_enum.yaml#/jak1/common" + JAK2: + $ref: + - "_terms_enum.yaml#/jak2/common" + JAK3: + $ref: + - "_terms_enum.yaml#/jak3/common" + JAZF1: + $ref: + - "_terms_enum.yaml#/jazf1/common" + JUN: + $ref: + - "_terms_enum.yaml#/jun/common" + KAT6A: + $ref: + - "_terms_enum.yaml#/kat6a/common" + KAT6B: + $ref: + - "_terms_enum.yaml#/kat6b/common" + KAT7: + $ref: + - "_terms_enum.yaml#/kat7/common" + KCNJ5: + $ref: + - "_terms_enum.yaml#/kcnj5/common" + KDM5A: + $ref: + - "_terms_enum.yaml#/kdm5a/common" + KDM5C: + $ref: + - "_terms_enum.yaml#/kdm5c/common" + KDM6A: + $ref: + - "_terms_enum.yaml#/kdm6a/common" + KDR: + $ref: + - "_terms_enum.yaml#/kdr/common" + KDSR: + $ref: + - "_terms_enum.yaml#/kdsr/common" + KEAP1: + $ref: + - "_terms_enum.yaml#/keap1/common" + KIAA1549: + $ref: + - "_terms_enum.yaml#/kiaa1549/common" + KIF5B: + $ref: + - "_terms_enum.yaml#/kif5b/common" + KIT: + $ref: + - "_terms_enum.yaml#/kit/common" + KLF4: + $ref: + - "_terms_enum.yaml#/klf4/common" + KLF6: + $ref: + - "_terms_enum.yaml#/klf6/common" + KLK2: + $ref: + - "_terms_enum.yaml#/klk2/common" + KMT2A: + $ref: + - "_terms_enum.yaml#/kmt2a/common" + KMT2C: + $ref: + - "_terms_enum.yaml#/kmt2c/common" + KMT2D: + $ref: + - "_terms_enum.yaml#/kmt2d/common" + KNL1: + $ref: + - "_terms_enum.yaml#/knl1/common" + KNSTRN: + $ref: + - "_terms_enum.yaml#/knstrn/common" + KRAS: + $ref: + - "_terms_enum.yaml#/kras/common" + KTN1: + $ref: + - "_terms_enum.yaml#/ktn1/common" + LARP4B: + $ref: + - "_terms_enum.yaml#/larp4b/common" + LASP1: + $ref: + - "_terms_enum.yaml#/lasp1/common" + LCK: + $ref: + - "_terms_enum.yaml#/lck/common" + LCP1: + $ref: + - "_terms_enum.yaml#/lcp1/common" + LEF1: + $ref: + - "_terms_enum.yaml#/lef1/common" + LHFP: + $ref: + - "_terms_enum.yaml#/lhfp/common" + LIFR: + $ref: + - "_terms_enum.yaml#/lifr/common" + LMNA: + $ref: + - "_terms_enum.yaml#/lmna/common" + LMO1: + $ref: + - "_terms_enum.yaml#/lmo1/common" + LMO2: + $ref: + - "_terms_enum.yaml#/lmo2/common" + LPP: + $ref: + - "_terms_enum.yaml#/lpp/common" + LRIG3: + $ref: + - "_terms_enum.yaml#/lrig3/common" + LRP1B: + $ref: + - "_terms_enum.yaml#/lrp1b/common" + LSM14A: + $ref: + - "_terms_enum.yaml#/lsm14a/common" + LYL1: + $ref: + - "_terms_enum.yaml#/lyl1/common" + LZTR1: + $ref: + - "_terms_enum.yaml#/lztr1/common" + MAF: + $ref: + - "_terms_enum.yaml#/maf/molecular_test/second_gene_symbol" + MAFB: + $ref: + - "_terms_enum.yaml#/mafb/common" + MALAT1: + $ref: + - "_terms_enum.yaml#/malat1/common" + MALT1: + $ref: + - "_terms_enum.yaml#/malt1/common" + MAML2: + $ref: + - "_terms_enum.yaml#/maml2/common" + MAML3: + $ref: + - "_terms_enum.yaml#/maml3/common" + MAP2K1: + $ref: + - "_terms_enum.yaml#/map2k1/common" + MAP2K2: + $ref: + - "_terms_enum.yaml#/map2k2/common" + MAP2K4: + $ref: + - "_terms_enum.yaml#/map2k4/common" + MAP3K1: + $ref: + - "_terms_enum.yaml#/map3k1/common" + MAP3K13: + $ref: + - "_terms_enum.yaml#/map3k13/common" + MAPK1: + $ref: + - "_terms_enum.yaml#/mapk1/common" + MAX: + $ref: + - "_terms_enum.yaml#/max/common" + MB21D2: + $ref: + - "_terms_enum.yaml#/mb21d2/common" + MDM2: + $ref: + - "_terms_enum.yaml#/mdm2/common" + MDM4: + $ref: + - "_terms_enum.yaml#/mdm4/common" + MDS2: + $ref: + - "_terms_enum.yaml#/mds2/common" + MECOM: + $ref: + - "_terms_enum.yaml#/mecom/common" + MED12: + $ref: + - "_terms_enum.yaml#/med12/common" + MEN1: + $ref: + - "_terms_enum.yaml#/men1/common" + MET: + $ref: + - "_terms_enum.yaml#/met/common" + MGMT: + $ref: + - "_terms_enum.yaml#/mgmt/common" + MITF: + $ref: + - "_terms_enum.yaml#/mitf/common" + MKL1: + $ref: + - "_terms_enum.yaml#/mkl1/common" + MLF1: + $ref: + - "_terms_enum.yaml#/mlf1/common" + MLH1: + $ref: + - "_terms_enum.yaml#/mlh1/common" + MLH2: + $ref: + - "_terms_enum.yaml#/mlh2/common" + MLLT1: + $ref: + - "_terms_enum.yaml#/mllt1/common" + MLLT3: + $ref: + - "_terms_enum.yaml#/mllt3/common" + MLLT4: + $ref: + - "_terms_enum.yaml#/mllt4/common" + MLLT6: + $ref: + - "_terms_enum.yaml#/mllt6/common" + MLLT10: + $ref: + - "_terms_enum.yaml#/mllt10/common" + MLLT11: + $ref: + - "_terms_enum.yaml#/mllt11/common" + MN1: + $ref: + - "_terms_enum.yaml#/mn1/common" + MNX1: + $ref: + - "_terms_enum.yaml#/mnx1/common" + MPL: + $ref: + - "_terms_enum.yaml#/mpl/common" + MSH2: + $ref: + - "_terms_enum.yaml#/msh2/common" + MSH6: + $ref: + - "_terms_enum.yaml#/msh6/common" + MSI2: + $ref: + - "_terms_enum.yaml#/msi2/common" + MSN: + $ref: + - "_terms_enum.yaml#/msn/common" + MTCP1: + $ref: + - "_terms_enum.yaml#/mtcp1/common" + MTOR: + $ref: + - "_terms_enum.yaml#/mtor/common" + MUC1: + $ref: + - "_terms_enum.yaml#/muc1/common" + MUC4: + $ref: + - "_terms_enum.yaml#/muc4/common" + MUC16: + $ref: + - "_terms_enum.yaml#/muc16/common" + MUTYH: + $ref: + - "_terms_enum.yaml#/mutyh/common" + MYB: + $ref: + - "_terms_enum.yaml#/myb/common" + MYC: + $ref: + - "_terms_enum.yaml#/myc/common" + MYCL: + $ref: + - "_terms_enum.yaml#/mycl/common" + MYCN: + $ref: + - "_terms_enum.yaml#/mycn/common" + MYD88: + $ref: + - "_terms_enum.yaml#/myd88/common" + MYH9: + $ref: + - "_terms_enum.yaml#/myh9/common" + MYH11: + $ref: + - "_terms_enum.yaml#/myh11/common" + MYO5A: + $ref: + - "_terms_enum.yaml#/myo5a/common" + MYOD1: + $ref: + - "_terms_enum.yaml#/myod1/common" + NAB2: + $ref: + - "_terms_enum.yaml#/nab2/common" + NACA: + $ref: + - "_terms_enum.yaml#/naca/common" + NBEA: + $ref: + - "_terms_enum.yaml#/nbea/common" + NBN: + $ref: + - "_terms_enum.yaml#/nbn/common" + NCKIPSD: + $ref: + - "_terms_enum.yaml#/nckipsd/common" + NCOA1: + $ref: + - "_terms_enum.yaml#/ncoa1/common" + NCOA2: + $ref: + - "_terms_enum.yaml#/ncoa2/common" + NCOA4: + $ref: + - "_terms_enum.yaml#/ncoa4/common" + NCOR1: + $ref: + - "_terms_enum.yaml#/ncor1/common" + NCOR2: + $ref: + - "_terms_enum.yaml#/ncor2/common" + NDRG1: + $ref: + - "_terms_enum.yaml#/ndrg1/common" + NF1: + $ref: + - "_terms_enum.yaml#/nf1/common" + NF2: + $ref: + - "_terms_enum.yaml#/nf2/common" + NFATC2: + $ref: + - "_terms_enum.yaml#/nfatc2/common" + NFE2L2: + $ref: + - "_terms_enum.yaml#/nfe2l2/common" + NFIB: + $ref: + - "_terms_enum.yaml#/nfib/common" + NFKB2: + $ref: + - "_terms_enum.yaml#/nfkb2/common" + NFKBIE: + $ref: + - "_terms_enum.yaml#/nfkbie/common" + NIN: + $ref: + - "_terms_enum.yaml#/nin/common" + NKX2-1: + $ref: + - "_terms_enum.yaml#/nkx21/common" + NONO: + $ref: + - "_terms_enum.yaml#/nono/common" + NOTCH1: + $ref: + - "_terms_enum.yaml#/notch1/common" + NOTCH2: + $ref: + - "_terms_enum.yaml#/notch2/common" + NPM1: + $ref: + - "_terms_enum.yaml#/npm1/common" + NR4A3: + $ref: + - "_terms_enum.yaml#/nr4a3/common" + NRAS: + $ref: + - "_terms_enum.yaml#/nras/common" + NRG1: + $ref: + - "_terms_enum.yaml#/nrg1/common" + NSD1: + $ref: + - "_terms_enum.yaml#/nsd1/common" + NSD2: + $ref: + - "_terms_enum.yaml#/nsd2/common" + NSD3: + $ref: + - "_terms_enum.yaml#/nsd3/common" + NT5C2: + $ref: + - "_terms_enum.yaml#/nt5c2/common" + NTHL1: + $ref: + - "_terms_enum.yaml#/nthl1/common" + NTRK1: + $ref: + - "_terms_enum.yaml#/ntrk1/common" + NTRK3: + $ref: + - "_terms_enum.yaml#/ntrk3/common" + NUMA1: + $ref: + - "_terms_enum.yaml#/numa1/common" + NUP98: + $ref: + - "_terms_enum.yaml#/nup98/common" + NUP214: + $ref: + - "_terms_enum.yaml#/nup214/common" + NUTM1: + $ref: + - "_terms_enum.yaml#/nutm1/common" + NUTM2A: + $ref: + - "_terms_enum.yaml#/nutm2a/common" + NUTM2B: + $ref: + - "_terms_enum.yaml#/nutm2b/common" + OLIG2: + $ref: + - "_terms_enum.yaml#/olig2/common" + OMD: + $ref: + - "_terms_enum.yaml#/omd/common" + P2RY8: + $ref: + - "_terms_enum.yaml#/p2ry8/common" + PABPC1: + $ref: + - "_terms_enum.yaml#/pabpc1/common" + PAFAH1B2: + $ref: + - "_terms_enum.yaml#/pafah1b2/common" + PALB2: + $ref: + - "_terms_enum.yaml#/palb2/common" + PATZ1: + $ref: + - "_terms_enum.yaml#/patz1/common" + PAX3: + $ref: + - "_terms_enum.yaml#/pax3/common" + PAX5: + $ref: + - "_terms_enum.yaml#/pax5/common" + PAX7: + $ref: + - "_terms_enum.yaml#/pax7/common" + PAX8: + $ref: + - "_terms_enum.yaml#/pax8/common" + PBRM1: + $ref: + - "_terms_enum.yaml#/pbrm1/common" + PBX1: + $ref: + - "_terms_enum.yaml#/pbx1/common" + PCBP1: + $ref: + - "_terms_enum.yaml#/pcbp1/common" + PCM1: + $ref: + - "_terms_enum.yaml#/pcm1/common" + PDCD1LG2: + $ref: + - "_terms_enum.yaml#/pdcd1lg2/common" + PDE4DIP: + $ref: + - "_terms_enum.yaml#/pde4dip/common" + PDGFB: + $ref: + - "_terms_enum.yaml#/pdgfb/common" + PDGFRA: + $ref: + - "_terms_enum.yaml#/pdgfra/common" + PDGFRB: + $ref: + - "_terms_enum.yaml#/pdgfrb/common" + PER1: + $ref: + - "_terms_enum.yaml#/per1/common" + PGR: + $ref: + - "_terms_enum.yaml#/pgr/common" + PHF6: + $ref: + - "_terms_enum.yaml#/phf6/common" + PHF23: + $ref: + - "_terms_enum.yaml#/phf23/common" + PHOX2B: + $ref: + - "_terms_enum.yaml#/phox2b/common" + PICALM: + $ref: + - "_terms_enum.yaml#/picalm/common" + PIK3CA: + $ref: + - "_terms_enum.yaml#/pik3ca/common" + PIK3CB: + $ref: + - "_terms_enum.yaml#/pik3cb/common" + PIK3R1: + $ref: + - "_terms_enum.yaml#/pik3r1/common" + PIM1: + $ref: + - "_terms_enum.yaml#/pim1/common" + PIM3: + $ref: + - "_terms_enum.yaml#/pim3/common" + PLAG1: + $ref: + - "_terms_enum.yaml#/plag1/common" + PLCG1: + $ref: + - "_terms_enum.yaml#/plcg1/common" + PML: + $ref: + - "_terms_enum.yaml#/pml/common" + PMS1: + $ref: + - "_terms_enum.yaml#/pms1/common" + PMS2: + $ref: + - "_terms_enum.yaml#/pms2/common" + POLD1: + $ref: + - "_terms_enum.yaml#/pold1/common" + POLE: + $ref: + - "_terms_enum.yaml#/pole/common" + POLG: + $ref: + - "_terms_enum.yaml#/polg/common" + POLQ: + $ref: + - "_terms_enum.yaml#/polq/common" + POT1: + $ref: + - "_terms_enum.yaml#/pot1/common" + POU2AF1: + $ref: + - "_terms_enum.yaml#/pou2af1/common" + POU5F1: + $ref: + - "_terms_enum.yaml#/pou5f1/common" + PPARG: + $ref: + - "_terms_enum.yaml#/pparg/common" + PPFIBP1: + $ref: + - "_terms_enum.yaml#/ppfibp1/common" + PPM1D: + $ref: + - "_terms_enum.yaml#/ppm1d/common" + PPP2R1A: + $ref: + - "_terms_enum.yaml#/ppp2r1a/common" + PPP6C: + $ref: + - "_terms_enum.yaml#/ppp6c/common" + PRCC: + $ref: + - "_terms_enum.yaml#/prcc/common" + PRDM1: + $ref: + - "_terms_enum.yaml#/prdm1/common" + PRDM2: + $ref: + - "_terms_enum.yaml#/prdm2/common" + PRDM16: + $ref: + - "_terms_enum.yaml#/prdm16/common" + PREX2: + $ref: + - "_terms_enum.yaml#/prex2/common" + PRF1: + $ref: + - "_terms_enum.yaml#/prf1/common" + PRKACA: + $ref: + - "_terms_enum.yaml#/prkaca/common" + PRKAR1A: + $ref: + - "_terms_enum.yaml#/prkar1a/common" + PRKCB: + $ref: + - "_terms_enum.yaml#/prkcb/common" + PRPF40B: + $ref: + - "_terms_enum.yaml#/prpf40b/common" + PRRX1: + $ref: + - "_terms_enum.yaml#/prrx1/common" + PSIP1: + $ref: + - "_terms_enum.yaml#/psip1/common" + PTCH1: + $ref: + - "_terms_enum.yaml#/ptch1/common" + PTEN: + $ref: + - "_terms_enum.yaml#/pten/common" + PTK6: + $ref: + - "_terms_enum.yaml#/ptk6/common" + PTP4A1: + $ref: + - "_terms_enum.yaml#/ptp4a1/common" + PTPN6: + $ref: + - "_terms_enum.yaml#/ptpn6/common" + PTPN11: + $ref: + - "_terms_enum.yaml#/ptpn11/common" + PTPN13: + $ref: + - "_terms_enum.yaml#/ptpn13/common" + PTPRB: + $ref: + - "_terms_enum.yaml#/ptprb/common" + PTPRC: + $ref: + - "_terms_enum.yaml#/ptprc/common" + PTPRK: + $ref: + - "_terms_enum.yaml#/ptprk/common" + PTPRT: + $ref: + - "_terms_enum.yaml#/ptprt/common" + PWWP2A: + $ref: + - "_terms_enum.yaml#/pwwp2a/common" + QKI: + $ref: + - "_terms_enum.yaml#/qki/common" + RABEP1: + $ref: + - "_terms_enum.yaml#/rabep1/common" + RAC1: + $ref: + - "_terms_enum.yaml#/rac1/common" + RAD21: + $ref: + - "_terms_enum.yaml#/rad21/common" + RAD51B: + $ref: + - "_terms_enum.yaml#/rad51b/common" + RAF1: + $ref: + - "_terms_enum.yaml#/raf1/common" + RALGDS: + $ref: + - "_terms_enum.yaml#/ralgds/common" + RANBP2: + $ref: + - "_terms_enum.yaml#/ranbp2/common" + RAP1GDS1: + $ref: + - "_terms_enum.yaml#/rap1gds1/common" + RARA: + $ref: + - "_terms_enum.yaml#/rara/common" + RB1: + $ref: + - "_terms_enum.yaml#/rb1/common" + RBM10: + $ref: + - "_terms_enum.yaml#/rbm10/common" + RBM15: + $ref: + - "_terms_enum.yaml#/rbm15/common" + RECQL4: + $ref: + - "_terms_enum.yaml#/recql4/common" + REL: + $ref: + - "_terms_enum.yaml#/rel/common" + RET: + $ref: + - "_terms_enum.yaml#/ret/common" + RGPD3: + $ref: + - "_terms_enum.yaml#/rgpd3/common" + RGS7: + $ref: + - "_terms_enum.yaml#/rgs7/common" + RHOA: + $ref: + - "_terms_enum.yaml#/rhoa/common" + RHOH: + $ref: + - "_terms_enum.yaml#/rhoh/common" + RMI2: + $ref: + - "_terms_enum.yaml#/rmi2/common" + RNF43: + $ref: + - "_terms_enum.yaml#/rnf43/common" + RNF213: + $ref: + - "_terms_enum.yaml#/rnf213/common" + ROBO2: + $ref: + - "_terms_enum.yaml#/robo2/common" + ROS1: + $ref: + - "_terms_enum.yaml#/ros1/common" + RPL5: + $ref: + - "_terms_enum.yaml#/rpl5/common" + RPL10: + $ref: + - "_terms_enum.yaml#/rpl10/common" + RPL22: + $ref: + - "_terms_enum.yaml#/rpl22/common" + RPN1: + $ref: + - "_terms_enum.yaml#/rpn1/common" + RSPO2: + $ref: + - "_terms_enum.yaml#/rspo2/common" + RSPO3: + $ref: + - "_terms_enum.yaml#/rspo3/common" + RUNX1: + $ref: + - "_terms_enum.yaml#/runx1/common" + RUNX1T1: + $ref: + - "_terms_enum.yaml#/runx1t1/common" + S100A7: + $ref: + - "_terms_enum.yaml#/s100a7/common" + SALL4: + $ref: + - "_terms_enum.yaml#/sall4/common" + SBDS: + $ref: + - "_terms_enum.yaml#/sbds/common" + SDC4: + $ref: + - "_terms_enum.yaml#/sdc4/common" + SDHA: + $ref: + - "_terms_enum.yaml#/sdha/common" + SDHAF2: + $ref: + - "_terms_enum.yaml#/sdhaf2/common" + SDHB: + $ref: + - "_terms_enum.yaml#/sdhb/common" + SDHC: + $ref: + - "_terms_enum.yaml#/sdhc/common" + SDHD: + $ref: + - "_terms_enum.yaml#/sdhd/common" + SEPT5: + $ref: + - "_terms_enum.yaml#/sept5/common" + SEPT6: + $ref: + - "_terms_enum.yaml#/sept6/common" + SEPT9: + $ref: + - "_terms_enum.yaml#/sept9/common" + SET: + $ref: + - "_terms_enum.yaml#/set/common" + SETBP1: + $ref: + - "_terms_enum.yaml#/setbp1/common" + SETD2: + $ref: + - "_terms_enum.yaml#/setd2/common" + SF3B1: + $ref: + - "_terms_enum.yaml#/sf3b1/common" + SFPQ: + $ref: + - "_terms_enum.yaml#/sfpq/common" + SFRP4: + $ref: + - "_terms_enum.yaml#/sfrp4/common" + SGK1: + $ref: + - "_terms_enum.yaml#/sgk1/common" + SH2B3: + $ref: + - "_terms_enum.yaml#/sh2b3/common" + SH3GL1: + $ref: + - "_terms_enum.yaml#/sh3gl1/common" + SHTN1: + $ref: + - "_terms_enum.yaml#/shtn1/common" + SIRPA: + $ref: + - "_terms_enum.yaml#/sirpa/common" + SKI: + $ref: + - "_terms_enum.yaml#/ski/common" + SLC34A2: + $ref: + - "_terms_enum.yaml#/slc34a2/common" + SLC45A3: + $ref: + - "_terms_enum.yaml#/slc45a3/common" + SMAD2: + $ref: + - "_terms_enum.yaml#/smad2/common" + SMAD3: + $ref: + - "_terms_enum.yaml#/smad3/common" + SMAD4: + $ref: + - "_terms_enum.yaml#/smad4/common" + SMARCA4: + $ref: + - "_terms_enum.yaml#/smarca4/common" + SMARCB1: + $ref: + - "_terms_enum.yaml#/smarcb1/common" + SMARCD1: + $ref: + - "_terms_enum.yaml#/smarcd1/common" + SMARCE1: + $ref: + - "_terms_enum.yaml#/smarce1/common" + SMC1A: + $ref: + - "_terms_enum.yaml#/smc1a/common" + SMO: + $ref: + - "_terms_enum.yaml#/smo/common" + SND1: + $ref: + - "_terms_enum.yaml#/snd1/common" + SNX29: + $ref: + - "_terms_enum.yaml#/snx29/common" + SOCS1: + $ref: + - "_terms_enum.yaml#/socs1/common" + SOX2: + $ref: + - "_terms_enum.yaml#/sox2/common" + SPECC1: + $ref: + - "_terms_enum.yaml#/specc1/common" + SPEN: + $ref: + - "_terms_enum.yaml#/spen/common" + SPOP: + $ref: + - "_terms_enum.yaml#/spop/common" + SRC: + $ref: + - "_terms_enum.yaml#/src/common" + SRGAP3: + $ref: + - "_terms_enum.yaml#/srgap3/common" + SRSF2: + $ref: + - "_terms_enum.yaml#/srsf2/common" + SRSF3: + $ref: + - "_terms_enum.yaml#/srsf3/common" + SS18: + $ref: + - "_terms_enum.yaml#/ss18/common" + SS18L1: + $ref: + - "_terms_enum.yaml#/ss18l1/common" + SSX1: + $ref: + - "_terms_enum.yaml#/ssx1/common" + SSX2: + $ref: + - "_terms_enum.yaml#/ssx2/common" + SSX4: + $ref: + - "_terms_enum.yaml#/ssx4/common" + STAG1: + $ref: + - "_terms_enum.yaml#/stag1/common" + STAG2: + $ref: + - "_terms_enum.yaml#/stag2/common" + STAT3: + $ref: + - "_terms_enum.yaml#/stat3/common" + STAT5B: + $ref: + - "_terms_enum.yaml#/stat5b/common" + STAT6: + $ref: + - "_terms_enum.yaml#/stat6/common" + STIL: + $ref: + - "_terms_enum.yaml#/stil/common" + STK11: + $ref: + - "_terms_enum.yaml#/stk11/common" + STRN: + $ref: + - "_terms_enum.yaml#/strn/common" + SUFU: + $ref: + - "_terms_enum.yaml#/sufu/common" + SUZ12: + $ref: + - "_terms_enum.yaml#/suz12/common" + SYK: + $ref: + - "_terms_enum.yaml#/syk/common" + SYP: + $ref: + - "_terms_enum.yaml#/syp/common" + TAF15: + $ref: + - "_terms_enum.yaml#/taf15/common" + TAL1: + $ref: + - "_terms_enum.yaml#/tal1/common" + TAL2: + $ref: + - "_terms_enum.yaml#/tal2/common" + TBL1XR1: + $ref: + - "_terms_enum.yaml#/tbl1xr1/common" + TBX3: + $ref: + - "_terms_enum.yaml#/tbx3/common" + TCEA1: + $ref: + - "_terms_enum.yaml#/tcea1/common" + TCF3: + $ref: + - "_terms_enum.yaml#/tcf3/common" + TCF7L2: + $ref: + - "_terms_enum.yaml#/tcf7l2/common" + TCF12: + $ref: + - "_terms_enum.yaml#/tcf12/common" + TCL1A: + $ref: + - "_terms_enum.yaml#/tcl1a/common" + TEC: + $ref: + - "_terms_enum.yaml#/tec/common" + TERT: + $ref: + - "_terms_enum.yaml#/tert/common" + TET1: + $ref: + - "_terms_enum.yaml#/tet1/common" + TET2: + $ref: + - "_terms_enum.yaml#/tet2/common" + TFE3: + $ref: + - "_terms_enum.yaml#/tfe3/common" + TFEB: + $ref: + - "_terms_enum.yaml#/tfeb/common" + TFG: + $ref: + - "_terms_enum.yaml#/tfg/common" + TFPT: + $ref: + - "_terms_enum.yaml#/tfpt/common" + TFRC: + $ref: + - "_terms_enum.yaml#/tfrc/common" + TGFBR2: + $ref: + - "_terms_enum.yaml#/tgfbr2/common" + THRAP3: + $ref: + - "_terms_enum.yaml#/thrap3/common" + TLX1: + $ref: + - "_terms_enum.yaml#/tlx1/common" + TLX3: + $ref: + - "_terms_enum.yaml#/tlx3/common" + TMEM127: + $ref: + - "_terms_enum.yaml#/tmem127/common" + TMPRSS2: + $ref: + - "_terms_enum.yaml#/tmprss2/common" + TNC: + $ref: + - "_terms_enum.yaml#/tnc/common" + TNFAIP3: + $ref: + - "_terms_enum.yaml#/tnfaip3/common" + TNFRSF14: + $ref: + - "_terms_enum.yaml#/tnfrsf14/common" + TNFRSF17: + $ref: + - "_terms_enum.yaml#/tnfrsf17/common" + TOP1: + $ref: + - "_terms_enum.yaml#/top1/common" + TOP2B: + $ref: + - "_terms_enum.yaml#/top2b/common" + TP53: + $ref: + - "_terms_enum.yaml#/tp53/common" + TP63: + $ref: + - "_terms_enum.yaml#/tp63/common" + TPM3: + $ref: + - "_terms_enum.yaml#/tpm3/common" + TPM4: + $ref: + - "_terms_enum.yaml#/tpm4/common" + TPR: + $ref: + - "_terms_enum.yaml#/tpr/common" + TRA: + $ref: + - "_terms_enum.yaml#/tra/common" + TRAF7: + $ref: + - "_terms_enum.yaml#/traf7/common" + TRB: + $ref: + - "_terms_enum.yaml#/trb/common" + TRD: + $ref: + - "_terms_enum.yaml#/trd/common" + TRIM24: + $ref: + - "_terms_enum.yaml#/trim24/common" + TRIM27: + $ref: + - "_terms_enum.yaml#/trim27/common" + TRIM33: + $ref: + - "_terms_enum.yaml#/trim33/common" + TRIP11: + $ref: + - "_terms_enum.yaml#/trip11/common" + TRRAP: + $ref: + - "_terms_enum.yaml#/trrap/common" + TSC1: + $ref: + - "_terms_enum.yaml#/tsc1/common" + TSC2: + $ref: + - "_terms_enum.yaml#/tsc2/common" + TSHR: + $ref: + - "_terms_enum.yaml#/tshr/common" + U2AF1: + $ref: + - "_terms_enum.yaml#/u2af1/common" + UBB: + $ref: + - "_terms_enum.yaml#/ubb/common" + UBR5: + $ref: + - "_terms_enum.yaml#/ubr5/common" + USP6: + $ref: + - "_terms_enum.yaml#/usp6/common" + USP8: + $ref: + - "_terms_enum.yaml#/usp8/common" + VAV1: + $ref: + - "_terms_enum.yaml#/vav1/common" + VHL: + $ref: + - "_terms_enum.yaml#/vhl/common" + VTI1A: + $ref: + - "_terms_enum.yaml#/vti1a/common" + WAS: + $ref: + - "_terms_enum.yaml#/was/common" + WDCP: + $ref: + - "_terms_enum.yaml#/wdcp/common" + WIF1: + $ref: + - "_terms_enum.yaml#/wif1/common" + WNK2: + $ref: + - "_terms_enum.yaml#/wnk2/common" + WRN: + $ref: + - "_terms_enum.yaml#/wrn/common" + WT1: + $ref: + - "_terms_enum.yaml#/wt1/common" + WWTR1: + $ref: + - "_terms_enum.yaml#/wwtr1/common" + XPA: + $ref: + - "_terms_enum.yaml#/xpa/common" + XPC: + $ref: + - "_terms_enum.yaml#/xpc/common" + XPO1: + $ref: + - "_terms_enum.yaml#/xpo1/common" + YWHAE: + $ref: + - "_terms_enum.yaml#/ywhae/common" + ZBTB16: + $ref: + - "_terms_enum.yaml#/zbtb16/common" + ZCCHC8: + $ref: + - "_terms_enum.yaml#/zcchc8/common" + ZEB1: + $ref: + - "_terms_enum.yaml#/zeb1/common" + ZEB2: + $ref: + - "_terms_enum.yaml#/zeb2/common" + ZFHX3: + $ref: + - "_terms_enum.yaml#/zfhx3/common" + ZMYM3: + $ref: + - "_terms_enum.yaml#/zmym3/common" + ZNF198: + $ref: + - "_terms_enum.yaml#/znf198/common" + ZNF331: + $ref: + - "_terms_enum.yaml#/znf331/common" + ZNF384: + $ref: + - "_terms_enum.yaml#/znf384/common" + ZNF429: + $ref: + - "_terms_enum.yaml#/znf429/common" + ZNF444: + $ref: + - "_terms_enum.yaml#/znf444/common" + ZNF479: + $ref: + - "_terms_enum.yaml#/znf479/common" + ZNF521: + $ref: + - "_terms_enum.yaml#/znf521/common" + ZNRF3: + $ref: + - "_terms_enum.yaml#/znrf3/common" + ZRSR2: + $ref: + - "_terms_enum.yaml#/zrsr2/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + specialized_molecular_test: + $ref: + - "_terms.yaml#/specialized_molecular_test/common" + type: string + + staining_intensity_scale: + $ref: + - "_terms.yaml#/staining_intensity_scale/common" + enum: + - 3 Point Scale + - 4 Point Scale + - Unknown + - Not Reported + + staining_intensity_value: + $ref: + - "_terms.yaml#/staining_intensity_value/common" + enum: + - "0" + - 1+ + - 2+ + - 3+ + - 4+ + - Unknown + - Not Reported + enumDef: + "0": + $ref: + - "_terms_enum.yaml#/staining_intensity_0/common" + 1+: + $ref: + - "_terms_enum.yaml#/staining_intensity_1/common" + 2+: + $ref: + - "_terms_enum.yaml#/staining_intensity_2/common" + 3+: + $ref: + - "_terms_enum.yaml#/staining_intensity_3/common" + 4+: + $ref: + - "_terms_enum.yaml#/staining_intensity_4/common" + + test_analyte_type: + $ref: + - "_terms.yaml#/test_analyte_type/common" + enum: + - DNA + - miRNA + - mRNA + - Protein + - Total RNA + - Unknown + - Not Reported + enumDef: + DNA: + $ref: + - "_terms_enum.yaml#/dna/common" + miRNA: + $ref: + - "_terms_enum.yaml#/mirna/common" + mRNA: + $ref: + - "_terms_enum.yaml#/mrna/common" + Protein: + $ref: + - "_terms_enum.yaml#/protein/common" + Total RNA: + $ref: + - "_terms_enum.yaml#/total_rna/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + test_result: + $ref: + - "_terms.yaml#/test_result/common" + enum: + - Abnormal, NOS + - Amplified + - Copy Number Reported + - Elevated + - Equivocal + - High + - Intermediate + - Loss of Expression + - Low + - Mitotic Count Reported + - Negative + - Normal + - Not Amplified + - Overexpressed + - Positive + - Stable + - Staining Intensity Value Reported + - Test Value Reported + - Unknown + - Not Reported + enumDef: + Abnormal, NOS: + $ref: + - "_terms_enum.yaml#/abnormal_nos/common" + Copy Number Reported: + $ref: + - "_terms_enum.yaml#/copy_number_reported/common" + Loss of Expression: + $ref: + - "_terms_enum.yaml#/loss_of_expression/common" + Negative: + $ref: + - "_terms_enum.yaml#/negative/common" + Normal: + $ref: + - "_terms_enum.yaml#/normal/common" + Overexpressed: + $ref: + - "_terms_enum.yaml#/overexpressed/common" + Positive: + $ref: + - "_terms_enum.yaml#/positive/common" + Test Value Reported: + $ref: + - "_terms_enum.yaml#/test_value_reported/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + test_units: + $ref: + - "_terms.yaml#/test_units/common" + enum: + - cells/mL + - g/dL + - g/L + - IU + - mcg/L + - mcg/mL + - mg/24 hr + - mg/dL + - mg/L + - mm^2 + - mmol/L + - mU/mol Hb + - ng/mL + - nmol/L + - percent + - Seconds + - U/g Hb + - U/L + - U/mL + - ukat/L + - umol/L + - x10^3 cells/mcL + - x10^6 cells/mcL + - x10^9 cells/L + - Unknown + - Not Reported + + test_value: + $ref: + - "_terms.yaml#/test_value/common" + type: number + + test_value_range: + $ref: + - "_terms.yaml#/test_value_range/common" + enum: + - 0-25 + - 26-50 + - 51-75 + - 76-100 + - 1-4% + - 5-9% + - <10% + - 10-19% + - 20-29% + - 30-39% + - 40-49% + - 50-59% + - 60-69% + - 70-79% + - 80-89% + - 90-99% + - <1% + - 1-49% + - '>=50%' + - 0-25% + - 26-50% + - 51-75% + - 76-100% + - Unknown + - Not Reported + deprecated_enum: + - 0-25 + - 26-50 + - 51-75 + - 76-100 + + timepoint_category: + $ref: + - "_terms.yaml#/timepoint_category/common" + enum: + - Adjuvant Therapy + - Adolescence + - Adulthood + - After Chemotherapy + - After Study Enrollment + - Childhood + - End of Consolidation Therapy + - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 + - First Complete Response + - First Treatment + - Follow-up + - Initial Diagnosis + - Last Contact + - Post Adjuvant Therapy + - Post Hormone Therapy + - Post Initial Treatment + - Post Secondary Therapy + - Postoperative + - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy + - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration + - Prior to Treatment + - Progression + - Recurrence + - Recurrence/Progression + - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment + - Within 3 Months of Surgery + - Other + - Unknown + - Not Reported + enumDef: + Preoperative: + $ref: + - "_terms_enum.yaml#/preoperative/common" + + transcript: + $ref: + - "_terms.yaml#/transcript/common" + type: string + pattern: "^ENST[0-9]{11}(\\.(0|[1-9][0-9]*))?$" + + variant_origin: + $ref: + - "_terms.yaml#/variant_origin/common" + enum: + - Germline + - Somatic + - Unknown + - Not Reported + enumDef: + Germline: + $ref: + - "_terms_enum.yaml#/germline/common" + Somatic: + $ref: + - "_terms_enum.yaml#/somatic/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + variant_type: + $ref: + - "_terms.yaml#/variant_type/common" + enum: + - Alleles + - Amplification + - Chrimerism + - Conversion + - Deletion + - Deletion-Insertion + - Duplication + - Extension + - Fusion + - Gain + - Genetic Polymorphism + - Hypermethylation + - Insertion + - Internal Tandem Duplication + - Inversion + - Loss + - Methylation + - Mosaicism + - Mutation, NOS + - Partial Methylation + - Rearrangement + - Repeated Sequences + - Splice + - Substitution + - Translocation + - Other + - Unknown + - Not Reported + enumDef: + Alleles: + $ref: + - "_terms_enum.yaml#/alleles/common" + Amplification: + $ref: + - "_terms_enum.yaml#/amplification/common" + Chrimerism: + $ref: + - "_terms_enum.yaml#/chrimerism/common" + Conversion: + $ref: + - "_terms_enum.yaml#/conversion/common" + Deletion: + $ref: + - "_terms_enum.yaml#/deletion/common" + Deletion-Insertion: + $ref: + - "_terms_enum.yaml#/deletioninsertion/common" + Duplication: + $ref: + - "_terms_enum.yaml#/duplication/common" + Extension: + $ref: + - "_terms_enum.yaml#/extension/common" + Gain: + $ref: + - "_terms_enum.yaml#/gain/common" + Hypermethylation: + $ref: + - "_terms_enum.yaml#/hypermethylation/common" + Insertion: + $ref: + - "_terms_enum.yaml#/insertion/common" + Inversion: + $ref: + - "_terms_enum.yaml#/inversion/common" + Loss: + $ref: + - "_terms_enum.yaml#/loss/common" + Methylation: + $ref: + - "_terms_enum.yaml#/methylation/common" + Mosaicism: + $ref: + - "_terms_enum.yaml#/mosaicism/common" + Partial Methylation: + $ref: + - "_terms_enum.yaml#/partial_methylation/common" + Rearrangement: + $ref: + - "_terms_enum.yaml#/rearrangement/common" + Repeated Sequences: + $ref: + - "_terms_enum.yaml#/repeated_sequences/common" + Splice: + $ref: + - "_terms_enum.yaml#/splice/common" + Substitution: + $ref: + - "_terms_enum.yaml#/substitution/common" + Translocation: + $ref: + - "_terms_enum.yaml#/translocation/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + zygosity: + $ref: + - "_terms.yaml#/zygosity/common" + enum: + - Hemizygous + - Heterozygous + - Homozygous + - Nullizygous + - Unknown + - Not Reported + enumDef: + Hemizygous: + $ref: + - "_terms_enum.yaml#/hemizygous/common" + Heterozygous: + $ref: + - "_terms_enum.yaml#/heterozygous/common" + Homozygous: + $ref: + - "_terms_enum.yaml#/homozygous/common" + Nullizygous: + $ref: + - "_terms_enum.yaml#/nullizygous/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + follow_ups: + $ref: "_definitions.yaml#/to_one" + + slides: + $ref: "_definitions.yaml#/to_one" + + diagnoses: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/other_clinical_attribute.yaml b/server/data_files/GDC/model-3.3.0/other_clinical_attribute.yaml new file mode 100644 index 0000000..c685d9f --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/other_clinical_attribute.yaml @@ -0,0 +1,1526 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "other_clinical_attribute" +title: Other Clinical Attribute +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Additional clinical attributes that are extraneous to other specific clinical entity + types within the GDC Data Dictionary. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: false + required: true + subgroup: + - name: cases + backref: other_clinical_attributes + label: describes + target_type: case + multiplicity: many_to_one + required: false + - name: follow_ups + backref: other_clinical_attributes + label: describes + target_type: follow_up + multiplicity: many_to_one + required: false + +required: + - submitter_id + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - pregnancy_count + - viral_hepatitis_serologies + - undescended_testis_corrected_age + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + aids_risk_factors: + $ref: + - "_terms.yaml#/aids_risk_factors/common" + enum: + - Candidiasis + - Coccidioidomycosis + - Cryptococcosis + - Cryptosporidiosis, Chronic Intestinal + - Cytomegalovirus + - Encephalopathy + - Herpes Simplex Virus + - Histoplasmosis + - Isosporiasis + - Mycobacterium avium Complex + - Mycobacterium tuberculosis + - Mycobacterium, NOS + - Nocardiosis + - Pneumocystis Pneumonia + - Pneumonia, NOS + - Progressive Multifocal Leukoencephalopathy + - Salmonella Septicemia + - Toxoplasmosis + - Wasting Syndrome + enumDef: + Pneumonia, NOS: + $ref: + - "_terms_enum.yaml#/pneumonia_nos/common" + + bmi: + $ref: + - "_terms.yaml#/bmi/common" + type: number + minimum: 0 + + body_surface_area: + $ref: + - "_terms.yaml#/body_surface_area/common" + type: number + minimum: 0 + + cd4_count: + $ref: + - "_terms.yaml#/cd4_count/common" + type: number + minimum: 0 + + cdc_hiv_risk_factors: + $ref: + - "_terms.yaml#/cdc_hiv_risk_factors/common" + enum: + - Hemophiliac + - Heterosexual Contact + - Homosexual Contact + - Intravenous Drug User + - None + - Transfusion Recipient + - Unknown + - Not Reported + enumDef: + None: + $ref: + - "_terms_enum.yaml#/none/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + comorbidities: + $ref: + - "_terms.yaml#/comorbidities/common" + type: array + items: + enum: + - Abnormal Glucose Level + - Acute Renal Failure + - Adenocarcinoma + - Adenomatous Polyposis Coli + - Adenomyosis + - Adenosis (Atypical Adenomatous Hyperplasia) + - Adrenocortical Insufficiency + - Alcoholic Liver Disease + - Allergies + - Allergy, Animal, NOS + - Allergy, Ant + - Allergy, Bee + - Allergy, Cat + - Allergy, Dairy or Lactose + - Allergy, Dog + - Allergy, Eggs + - Allergy, Food, NOS + - Allergy, Fruit + - Allergy, Meat + - Allergy, Mold or Dust + - Allergy, Nuts + - Allergy, Processed Foods + - Allergy, Seafood + - Allergy, Wasp + - Alpha-1 Antitrypsin + - Alpha-1 Antitrypsin Deficiency + - Altered Mental Status + - Androgen Excess + - Anemia + - Anxiety + - Arrhythmia + - Arthritis + - Asthma + - Ataxia-Telangiectasia + - Atrial Fibrillation + - Autoimmune Atrophic Chronic Gastritis + - Autoimmune Lymphoproliferative Syndrome (ALPS) + - Avascular Necrosis + - Bacteroides fragilis + - BAP1 Tumor Predisposition Syndrome + - Barrett's Esophagus + - Basal Cell Carcinoma + - Beckwith-Wiedemann + - Behcet's Disease + - Benign Prostatic Hyperplasia + - Benign Thyroid Nodule + - Biliary Disorder + - Birt-Hogg-Dube Syndrome + - BK Virus + - Blood Clots + - Bone Fracture(s) + - Bronchitis + - Calcium Channel Blockers + - Cancer + - Cataracts + - Celiac Disease + - Cerebrovascular Disease + - Chlamydia + - Chloroma + - Cholelithiasis + - Chronic Fatigue Syndrome + - Chronic Kidney Disease + - Chronic Pancreatitis + - Chronic Renal Failure + - Chronic Systemic Steroid Use + - Chronic Thyroiditis + - Cirrhosis, Unknown Etiology + - Clonal Hematopoiesis + - CNS Infection + - Colon Polyps + - Colonization, Bacterial + - Colonization, Fungal + - Common Variable Immune Deficiency (CVID) + - Common Variable Immunodeficiency + - Congestive Heart Failure (CHF) + - Connective Tissue Disorder + - COPD + - Coronary Artery Disease + - Cortisol Excess + - Cowden Syndrome + - Crohn's Disease + - Cryptococcal Meningitis + - Cryptogenic Organizing Pneumonia + - Cyst(s) + - Cytomegalovirus (CMV) + - Deep Vein Thrombosis / Thromboembolism + - Dementia + - Denys-Drash Syndrome + - Depression + - Dermatomyosis + - Diabetes + - Diabetes, NOS + - Diabetes, Type I + - Diabetes, Type II + - Diabetic Neuropathy + - Diet Controlled Diabetes + - Diverticulitis + - Diverticulosis + - Down Syndrome + - DVT/PE + - Dyslipidemia + - EBV Lymphoproliferation + - Eczema + - Endometriosis + - Endosalpingiosis + - Epilepsy + - Epithelial Dysplasia + - Epithelial Hyperplasia + - Epstein-Barr Virus + - Escherichia coli + - Estrogen Excess + - Familial Adenomatous Polyposis + - Fanconi Anemia + - Fibromyalgia + - Fibrosis + - Follicular Adenoma + - Gastric Polyp(s) + - Gastritis + - Gastroesophageal Reflux Disease + - GERD + - Gilbert's Syndrome + - Glaucoma + - Glomerular Disease + - Glycogen Storage Disease + - Goiter + - Gonadal Dysfunction + - Gorlin Syndrome + - Gout + - Graves' Disease + - Hashimoto's Thyroiditis + - Hay Fever + - Headache + - Heart Disease + - Helicobacter pylori Infection + - Helicobacter pylori-Associated Gastritis + - Hematologic Disorder, NOS + - Hemihypertrophy + - Hemochromatosis + - Hemorrhagic Cystitis + - Hepatic Encephalopathy + - Hepatitis + - Hepatitis A Infection + - Hepatitis B Infection + - Hepatitis C Infection + - Hepatitis, Chronic + - Hepatitis, NOS + - Hereditary Breast Cancer + - Hereditary Hemorrhagic Telangiectasia + - Hereditary Kidney Oncocytoma + - Hereditary Leiomyomatosis and Renal Cell Carcinoma + - Hereditary Non-Polyposis Colon Cancer + - Hereditary Ovarian Cancer + - Hereditary Papillary Renal Cell Carcinoma + - Hereditary Prostate Cancer + - Hereditary Renal Cell Carcinoma + - Herpes + - Herpes Zoster + - High Grade Dysplasia + - High Grade Liver Dysplastic Nodule + - High-grade Prostatic Intraepithelial Neoplasia (PIN) + - HIV/AIDS + - Hodgkin Lymphoma + - Human Herpesvirus-6 (HHV-6) + - Human Herpesvirus-8 (HHV-8) + - Human Papillomavirus Infection + - HUS/TTP + - Hypercalcemia + - Hypercholesterolemia + - Hyperglycemia + - Hyperlipidemia + - Hyperparathyroidism + - Hypertension + - Hyperthyroidism + - Hypospadias + - Hypothyroidism + - Inflammation + - Inflammation, Hyperkeratosis + - Inflammatory Bowel Disease + - Inherited Genetic Syndrome, NOS + - Insulin Controlled Diabetes + - Interstitial Pneumonitis or ARDS + - Intestinal Metaplasia + - Intraductal Papillary Mucinous Neoplasm + - Iron Overload + - Ischemic Heart Disease + - ITP + - Joint Replacement + - Kidney Disease + - Li-Fraumeni Syndrome + - Liver Cirrhosis (Liver Disease) + - Liver Toxicity (Non-Infectious) + - Low Grade Dysplasia + - Low Grade Liver Dysplastic Nodule + - Lupus + - Lymphamatoid Papulosis + - Lymphocytic Meningitis + - Lymphocytic Thyroiditis + - Lymphoid Hyperplasia + - Lynch Syndrome + - MAI + - Malaria + - Metabolic Syndrome + - Methicillin-Resistant Staphylococcus aureus (MRSA) + - Mineralcorticoids Excess + - Motor / Movement Change + - Myasthenia Gravis + - Mycobacterium avium Complex + - Myelodysplastic Syndrome + - Myocardial Infarction + - Neurocystericerosis + - Neuroendocrine Tumor + - Nevus of Ota + - Nodular Hyperplasia + - Nodular Prostatic Hyperplasia + - Nonalcoholic Fatty Liver Disease + - Nonalcoholic Steatohepatitis + - Obesity + - Organ Transplant (Site) + - Osteoarthritis + - Osteoporosis or Osteopenia + - Other Cancer within 5 Years + - Other Nonmalignant Systemic Disease + - Other Pulmonary Complications + - Pain (Various) + - Pancreatitis + - Parasitic Disease of Biliary Tract + - Parkinson's Disease + - Peptic Ulcer (Ulcer) + - Peripheral Neuropathy + - Peripheral Vascular Disease + - Peutz-Jeghers Disease + - Pneumocystis Pneumonia + - Pneumonia, NOS + - Polycystic Ovarian Syndrome (PCOS) + - Pregnancy in Patient or Partner + - Primary Sclerosing Cholangitis + - Psoriasis + - Pulmonary Fibrosis + - Pulmonary Hemorrhage + - Recurrent Pyogenic Cholangitis + - Renal Dialysis + - Renal Failure (Requiring Dialysis) + - Renal Insufficiency + - Rheumatoid Arthritis + - Rheumatologic Disease + - Rubella + - Rubinstein-Taybi Syndrome + - Sarcoidosis + - Scarlet Fever + - Seizure + - Sensory Changes + - Serous Tubal Intraepithelial Carcinoma (STIC) + - Shingles + - Sialadenitis + - Sjogren's Syndrome + - Skin Rash + - Sleep Apnea + - Smoking + - Squamous Metaplasia + - Staph Osteomyelitis + - Staphylococcus aureus + - Steatosis + - Stroke + - Succinate Dehydrogenase-Deficient Renal Cell Carcinoma + - Syphilis + - Thyroid Disease, Non-Cancer + - Thyroid Nodular Hyperplasia + - Tobacco, NOS + - Tobacco, Smokeless + - Tobacco, Smoking + - Transient Ischemic Attack + - Treponema pallidum + - Tuberculosis + - Tuberous Sclerosis + - Tubulointerstitial Disease + - Tumor-Associated Lymphoid Proliferation + - Turcot Syndrome + - Tyrosinemia + - Ulcerative Colitis + - Undescended Testis + - Urinary Tract Infection + - Varicella Zoster Virus + - Vascular Disease + - Vision Changes + - Von Hippel-Lindau Syndrome + - Wagr Syndrome + - Other + - Unknown + - Not Reported + deprecated_enum: + - Alpha-1 Antitrypsin + - Diabetes + - Gastroesophageal Reflux Disease + - Hepatitis + - Kidney Disease + - Smoking + enumDef: + Cancer: + $ref: + - "_terms_enum.yaml#/cancer/common" + Epstein-Barr Virus: + $ref: + - "_terms_enum.yaml#/epsteinbarr_virus/common" + Pneumocystis Pneumonia: + $ref: + - "_terms_enum.yaml#/pneumonia_nos/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + comorbidity_method_of_diagnosis: + $ref: + - "_terms.yaml#/comorbidity_method_of_diagnosis/common" + enum: + - Histology + - Pathology + - Radiology + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + days_to_comorbidity: + $ref: + - "_terms.yaml#/days_to_comorbidity/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_risk_factor: + $ref: + - "_terms.yaml#/days_to_risk_factor/common" + type: integer + maximum: 32872 + minimum: -32872 + + diabetes_treatment_type: + $ref: + - "_terms.yaml#/diabetes_treatment_type/common" + enum: + - Alpha-Glucosidase Inhibitor + - Biguanide + - Diet + - Injected Insulin + - Insulin + - Linagliptin + - Oral Hypoglycemic + - Sulfonylurea + - Thiazolidinedione + - Other + - Unknown + - Not Reported + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + dlco_ref_predictive_percent: + $ref: + - "_terms.yaml#/dlco_ref_predictive_percent/common" + type: number + minimum: 0 + + exercise_frequency_weekly: + description: >- + Text term that indicates the number of days that exercise occurred in the past + seven days. + enum: + - 5 or More Days + - 3 to 4 Days + - 1 to 2 Days + - None + enumDef: + None: + $ref: + - "_terms_enum.yaml#/none/common" + + eye_color: + $ref: + - "_terms.yaml#/eye_color/common" + enum: + - Amber + - Blue + - Brown + - Gray + - Green + - Hazel + - Red & Violet + - Other + - Unknown + - Not Reported + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + fev1_fvc_post_bronch_percent: + $ref: + - "_terms.yaml#/fev1_fvc_post_bronch_percent/common" + type: number + minimum: 0 + + fev1_fvc_pre_bronch_percent: + $ref: + - "_terms.yaml#/fev1_fvc_pre_bronch_percent/common" + type: number + minimum: 0 + + fev1_ref_post_bronch_percent: + $ref: + - "_terms.yaml#/fev1_ref_post_bronch_percent/common" + type: number + minimum: 0 + + fev1_ref_pre_bronch_percent: + $ref: + - "_terms.yaml#/fev1_ref_pre_bronch_percent/common" + type: number + minimum: 0 + + haart_treatment_indicator: + $ref: + - "_terms.yaml#/haart_treatment_indicator/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + height: + $ref: + - "_terms.yaml#/height/common" + type: number + minimum: 0 + + hepatitis_sustained_virological_response: + $ref: + - "_terms.yaml#/hepatitis_sustained_virological_response/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hiv_viral_load: + $ref: + - "_terms.yaml#/hiv_viral_load/common" + type: number + minimum: 0 + + hormonal_contraceptive_type: + $ref: + - "_terms.yaml#/hormonal_contraceptive_type/common" + enum: + - Progestin + - Progestin and Estrogen + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hormonal_contraceptive_use: + $ref: + - "_terms.yaml#/hormonal_contraceptive_use/common" + enum: + - Current User + - Former User + - Never Used + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hormonal_replacement_therapy_status: + $ref: + - "_terms.yaml#/hormonal_replacement_therapy_status/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + + hormone_replacement_therapy_type: + $ref: + - "_terms.yaml#/hormone_replacement_therapy_type/common" + enum: + - Estrogen only + - Progesterone and Estrogen + - Progesterone only + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hysterectomy_margins_involved: + $ref: + - "_terms.yaml#/hysterectomy_margins_involved/common" + enum: + - Bladder + - Macroscopic Parametrium + - Microscopic Parametrium + - None + - Vagina + - Unknown + - Not Reported + enumDef: + None: + $ref: + - "_terms_enum.yaml#/none/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + hysterectomy_type: + $ref: + - "_terms.yaml#/hysterectomy_type/common" + enum: + - Hysterectomy, NOS + - Not Performed + - Radical Hysterectomy + - Simple Hysterectomy + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + immunosuppressive_treatment_type: + $ref: + - "_terms.yaml#/immunosuppressive_treatment_type/common" + enum: + - Anti-TNF Therapy + - Azathioprine + - Cyclophosphamide + - Immunoglobulin + - Methotrexate + - None + - Prednisone + - Other + - Unknown + - Not Reported + enumDef: + None: + $ref: + - "_terms_enum.yaml#/none/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + menopause_status: + $ref: + - "_terms.yaml#/menopause_status/common" + enum: + - Perimenopausal + - Postmenopausal + - Premenopausal + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + myasthenia_gravis_classification: + $ref: + - "_terms.yaml#/myasthenia_gravis_classification/common" + enum: + - Class I + - Class II + - Class III + - Class IV + - Class V + enumDef: + Class I: + $ref: + - "_terms_enum.yaml#/i/other_clinical_attribute/myasthenia_gravis_classification" + Class II: + $ref: + - "_terms_enum.yaml#/ii/other_clinical_attribute/myasthenia_gravis_classification" + Class III: + $ref: + - "_terms_enum.yaml#/iii/other_clinical_attribute/myasthenia_gravis_classification" + Class IV: + $ref: + - "_terms_enum.yaml#/iv/other_clinical_attribute/myasthenia_gravis_classification" + Class V: + $ref: + - "_terms_enum.yaml#/v/other_clinical_attribute/myasthenia_gravis_classification" + + nadir_cd4_count: + $ref: + - "_terms.yaml#/nadir_cd4_count/common" + type: number + minimum: 0 + + nononcologic_therapeutic_agents: + description: >- + Text identification of the individual agent(s) used as part of a treatment regimen + not related to an oncologic disease. + enum: + - Acetaminophen + - Aspirin + - Metformin + - Statin, NOS + - Unknown + - Not Reported + enumDef: + Acetaminophen: + $ref: + - "_terms_enum.yaml#/acetaminophen/common" + Aspirin: + $ref: + - "_terms_enum.yaml#/aspirin/common" + Metformin: + $ref: + - "_terms_enum.yaml#/metformin/common" + + number_of_pregnancies: + $ref: + - "_terms.yaml#/number_of_pregnancies/common" + enum: + - "0" + - "1" + - "2" + - "3" + - 4+ + - Unknown + - Not Reported + + oxygen_use_indicator: + $ref: + - "_terms.yaml#/oxygen_use_indicator/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + oxygen_use_type: + $ref: + - "_terms.yaml#/oxygen_use_type/common" + enum: + - Continuous + - Intermittent + - Unknown + - Not Reported + enumDef: + Continuous: + $ref: + - "_terms_enum.yaml#/continuous/common" + Intermittent: + $ref: + - "_terms_enum.yaml#/intermittent/common" + + pancreatitis_onset_year: + $ref: + - "_terms.yaml#/pancreatitis_onset_year/common" + type: integer + minimum: 1900 + + pregnancy_count: + $ref: + - "_terms.yaml#/pregnancy_count/common" + type: integer + minimum: 0 + + pregnancy_outcome: + $ref: + - "_terms.yaml#/pregnancy_outcome/common" + enum: + - Ectopic Pregnancy + - Full Term Birth, NOS + - Induced Abortion + - Live Birth + - Miscarriage + - Spontaneous Abortion + - Stillbirth + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + pregnant_at_diagnosis: + $ref: + - "_terms.yaml#/pregnant_at_diagnosis/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + premature_at_birth: + $ref: + - "_terms.yaml#/premature_at_birth/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + reflux_treatment_type: + $ref: + - "_terms.yaml#/reflux_treatment_type/common" + enum: + - Antacids + - H2 Blockers + - Medically Treated + - No Treatment + - Proton Pump Inhibitors + - Surgically Treated + - Unknown + - Not Reported + - Not Applicable + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + risk_factor_method_of_diagnosis: + $ref: + - "_terms.yaml#/risk_factor_method_of_diagnosis/common" + enum: + - Biochemical Assessment + - Both Clinical and Biochemical Assessments + - Clinical Assessment + - Unknown + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + risk_factor_treatment: + $ref: + - "_terms.yaml#/risk_factor_treatment/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + risk_factors: + $ref: + - "_terms.yaml#/risk_factors/common" + type: array + items: + enum: + - Abnormal Glucose Level + - Adenocarcinoma + - Adenomatous Polyposis Coli + - Adenomyosis + - Adenosis (Atypical Adenomatous Hyperplasia) + - Alcohol Consumption + - Alcoholic Liver Disease + - Allergies + - Allergy, Animal, NOS + - Allergy, Ant + - Allergy, Bee + - Allergy, Cat + - Allergy, Dairy or Lactose + - Allergy, Dog + - Allergy, Eggs + - Allergy, Food, NOS + - Allergy, Fruit + - Allergy, Meat + - Allergy, Mold or Dust + - Allergy, Nuts + - Allergy, Processed Foods + - Allergy, Seafood + - Allergy, Wasp + - Alpha-1 Antitrypsin Deficiency + - Altered Mental Status + - Androgen Excess + - Anemia + - Arthritis + - Asthma + - Ataxia-Telangiectasia + - Atrial Fibrillation + - Autoimmune Atrophic Chronic Gastritis + - Autoimmune Lymphoproliferative Syndrome (ALPS) + - Bacteroides fragilis + - BAP1 Tumor Predisposition Syndrome + - Barrett's Esophagus + - Basal Cell Carcinoma + - Beckwith-Wiedemann + - Behcet's Disease + - Benign Prostatic Hyperplasia + - Benign Thyroid Nodule + - Biliary Disorder + - Birt-Hogg-Dube Syndrome + - BK Virus + - BRCA Family History + - Bronchitis + - Calcium Channel Blockers + - Cancer + - Cataracts + - Celiac Disease + - Cerebrovascular Disease + - Chlamydia + - Chloroma + - Cholelithiasis + - Chronic Fatigue Syndrome + - Chronic Hepatitis + - Chronic Kidney Disease + - Chronic Pancreatitis + - Chronic Systemic Steroid Use + - Chronic Thyroiditis + - Cirrhosis + - Clonal Hematopoiesis + - CNS Infection + - Colon Polyps + - Colonization, Bacterial + - Colonization, Fungal + - Common Variable Immune Deficiency (CVID) + - Common Variable Immunodeficiency + - Congestive Heart Failure (CHF) + - Connective Tissue Disorder + - COPD + - Coronary Artery Disease + - Cortisol Excess + - Cowden Syndrome + - Crohn's Disease + - Cryptococcal Meningitis + - Cryptogenic Organizing Pneumonia + - Cyst(s) + - Cytomegalovirus (CMV) + - Denys-Drash Syndrome + - Dermatomyosis + - Diabetes, NOS + - Diabetes, Type I + - Diabetes, Type II + - Diet + - Diverticulitis + - Diverticulosis + - Down Syndrome + - Dyslipidemia + - EBV Lymphoproliferation + - Eczema + - Endometriosis + - Endosalpingiosis + - Epithelial Dysplasia + - Epithelial Hyperplasia + - Epstein-Barr Virus + - Escherichia coli + - Estrogen Excess + - Familial Adenomatous Polyposis + - Fanconi Anemia + - Fibrosis + - Follicular Adenoma + - Gastric Polyp(s) + - Gastritis + - GERD + - Gilbert's Syndrome + - Glaucoma + - Glomerular Disease + - Glycogen Storage Disease + - Goiter + - Gorlin Syndrome + - Gout + - Graves' Disease + - Hashimoto's Thyroiditis + - Hay Fever + - Headache + - Heart Disease + - Helicobacter pylori Infection + - Helicobacter pylori-Associated Gastritis + - Hematologic Disorder, NOS + - Hemihypertrophy + - Hemochromatosis + - Hepatic Encephalopathy + - Hepatitis A Infection + - Hepatitis B Infection + - Hepatitis C Infection + - Hepatitis, Chronic + - Hepatitis, NOS + - Hereditary Breast Cancer + - Hereditary Hemorrhagic Telangiectasia + - Hereditary Kidney Oncocytoma + - Hereditary Leiomyomatosis and Renal Cell Carcinoma + - Hereditary Non-Polyposis Colon Cancer + - Hereditary Ovarian Cancer + - Hereditary Papillary Renal Cell Carcinoma + - Hereditary Prostate Cancer + - Hereditary Renal Cell Carcinoma + - Herpes + - Herpes Simplex Virus + - Herpes Zoster + - High Grade Dysplasia + - High Grade Liver Dysplastic Nodule + - High-grade Prostatic Intraepithelial Neoplasia (PIN) + - HIV + - HIV/AIDS + - Hodgkin Lymphoma + - Human Herpesvirus-6 (HHV-6) + - Human Herpesvirus-8 (HHV-8) + - Human Papillomavirus Infection + - Hypercholesterolemia + - Hyperglycemia + - Hyperlipidemia + - Hyperparathyroidism + - Hypertension + - Hyperthyroidism + - Hypospadias + - Hypothyroidism + - Inflammation + - Inflammation, Hyperkeratosis + - Inflammatory Bowel Disease + - Inherited Genetic Syndrome, NOS + - Interstitial Pneumonitis or ARDS + - Intestinal Metaplasia + - Intraductal Papillary Mucinous Neoplasm + - Iron Overload + - Ischemic Heart Disease + - ITP + - Li-Fraumeni Syndrome + - Liver Cirrhosis (Liver Disease) + - Low Grade Dysplasia + - Low Grade Liver Dysplastic Nodule + - Lupus + - Lymphamatoid Papulosis + - Lymphocytic Meningitis + - Lymphocytic Thyroiditis + - Lymphoid Hyperplasia + - Lynch Syndrome + - Malaria + - Metabolic Syndrome + - Mineralcorticoids Excess + - Motor / Movement Change + - Myasthenia Gravis + - Mycobacterium avium Complex + - Myelodysplastic Syndrome + - Myocardial Infarction + - Neurocystericerosis + - Neuroendocrine Tumor + - Nevus of Ota + - Nodular Hyperplasia + - Nodular Prostatic Hyperplasia + - Nonalcoholic Fatty Liver Disease + - Nonalcoholic Steatohepatitis + - None + - Obesity + - Oral Contraceptives + - Organ Transplant (Site) + - Osteoarthritis + - Pancreatitis + - Parasitic Disease of Biliary Tract + - Peptic Ulcer (Ulcer) + - Peripheral Vascular Disease + - Peutz-Jeghers Disease + - Pneumocystis Pneumonia + - Pneumonia, NOS + - Polycystic Ovarian Syndrome (PCOS) + - Pregnancy in Patient or Partner + - Primary Sclerosing Cholangitis + - Psoriasis + - Pulmonary Fibrosis + - Recurrent Pyogenic Cholangitis + - Reflux Disease + - Renal Failure (Requiring Dialysis) + - Renal Insufficiency + - Rheumatoid Arthritis + - Rheumatologic Disease + - Rubella + - Rubinstein-Taybi Syndrome + - Sarcoidosis + - Scarlet Fever + - Seizure + - Sensory Changes + - Serous Tubal Intraepithelial Carcinoma (STIC) + - Shingles + - Sialadenitis + - Sjogren's Syndrome + - Skin Rash + - Sleep Apnea + - Squamous Metaplasia + - Staph Osteomyelitis + - Staphylococcus aureus + - Steatosis + - Succinate Dehydrogenase-Deficient Renal Cell Carcinoma + - Syphilis + - Tattoo + - Thyroid Disease, Non-Cancer + - Thyroid Nodular Hyperplasia + - Tobacco, NOS + - Tobacco, Smokeless + - Tobacco, Smoking + - Treponema pallidum + - Tuberculosis + - Tuberous Sclerosis + - Tubulointerstitial Disease + - Tumor-associated Lymphoid Proliferation + - Turcot Syndrome + - Tyrosinemia + - Ulcerative Colitis + - Undescended Testis + - Urinary Tract Infection + - Varicella Zoster Virus + - Vascular Disease + - Vision Changes + - Von Hippel-Lindau Syndrome + - Wagr Syndrome + - Unknown + - Not Reported + deprecated_enum: + - Chronic Hepatitis + - Cirrhosis + - HIV + - Reflux Disease + enumDef: + Cancer: + $ref: + - "_terms_enum.yaml#/cancer/common" + Epstein-Barr Virus: + $ref: + - "_terms_enum.yaml#/epsteinbarr_virus/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + timepoint_category: + $ref: + - "_terms.yaml#/timepoint_category/common" + enum: + - Adjuvant Therapy + - Adolescence + - Adulthood + - After Chemotherapy + - After Study Enrollment + - Childhood + - End of Consolidation Therapy + - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 + - First Complete Response + - First Treatment + - Follow-up + - Initial Diagnosis + - Last Contact + - Post Adjuvant Therapy + - Post Hormone Therapy + - Post Initial Treatment + - Post Secondary Therapy + - Postoperative + - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy + - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration + - Prior to Treatment + - Progression + - Recurrence + - Recurrence/Progression + - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment + - Within 3 Months of Surgery + - Other + - Unknown + - Not Reported + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_frequency: + $ref: + - "_terms.yaml#/treatment_frequency/common" + enum: + - Every Hour + - Five Times Daily + - Four Times Daily + - Three Times Daily + - Twice Daily + - Once Daily + - Every Other Day + - Twice Weekly + - Once Weekly + - Once a Week for at Least a Year + - Occasionally + - Never + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_corrected: + $ref: + - "_terms.yaml#/undescended_testis_corrected/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_corrected_age: + $ref: + - "_terms.yaml#/undescended_testis_corrected_age/common" + type: integer + maximum: 89 + minimum: 0 + + undescended_testis_corrected_age_range: + $ref: + - "_terms.yaml#/undescended_testis_corrected_age/common" + enum: + - 2-11 months + - 1-2 years + - 3-9 years + - 10-14 years + - Unknown + - Not Reported + + undescended_testis_corrected_laterality: + $ref: + - "_terms.yaml#/undescended_testis_corrected_laterality/common" + enum: + - Bilateral + - Left + - Right + - Unknown + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_corrected_method: + $ref: + - "_terms.yaml#/undescended_testis_corrected_method/common" + enum: + - Hormones + - Orchiopexy + - Spontaneous Descent + - Testis Removed + - Unknown + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_history: + $ref: + - "_terms.yaml#/undescended_testis_history/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + undescended_testis_history_laterality: + $ref: + - "_terms.yaml#/undescended_testis_history_laterality/common" + enum: + - Bilateral + - Left + - Right + - Unknown + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + viral_hepatitis_serologies: + $ref: + - "_terms.yaml#/viral_hepatitis_serologies/common" + enum: + - HBV Core Antibody + - HBV DNA + - HBV Genotype + - HBV Surface Antibody + - HCV Genotype + - Hepatitis B Surface Antigen + - Hepatitis C Antibody + - Hepatitis C Virus RNA + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + viral_hepatitis_serology_tests: + $ref: + - "_terms.yaml#/viral_hepatitis_serology_tests/common" + type: array + items: + enum: + - HBV Core Antibody + - HBV DNA + - HBV Genotype + - HBV Surface Antibody + - HCV Genotype + - Hepatitis B Surface Antigen + - Hepatitis C Antibody + - Hepatitis C Virus RNA + - Unknown + - Not Reported + + weeks_gestation_at_birth: + $ref: + - "_terms.yaml#/weeks_gestation_at_birth/common" + type: number + minimum: 0 + + weight: + $ref: + - "_terms.yaml#/weight/common" + type: number + minimum: 0 + + cases: + $ref: "_definitions.yaml#/to_one" + + follow_ups: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/pathology_detail.yaml b/server/data_files/GDC/model-3.3.0/pathology_detail.yaml new file mode 100644 index 0000000..877d9eb --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/pathology_detail.yaml @@ -0,0 +1,1323 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "pathology_detail" +title: Pathology Detail +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Information derived from a pathologic review of a specific sample or slide that + was not known to be submitted to the GDC. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: diagnoses + backref: pathology_details + label: describes + target_type: diagnosis + multiplicity: many_to_one + required: true + +required: + - submitter_id + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - epithelioid_cell_percent + - extrascleral_extension + - size_extraocular_nodule + - spindle_cell_percent + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + additional_pathology_findings: + $ref: + - "_terms.yaml#/additional_pathology_findings/common" + enum: + - Adenomyosis + - Asbestos bodies + - Atrophic endometrium + - Atypical hyperplasia/Endometrial intraepithelial neoplasia (EIN) + - Autoimmune atrophic chronic gastritis + - Benign endocervical polyp + - Bilateral ovaries with endometriotic cyst and surface adhesions + - Bone marrow concordant histology + - Bone marrow discordant histology + - Carcinoma in situ + - Cirrhosis + - Clostridioides difficile (c. diff) + - Colonization; bacterial + - Colonization; fungal + - Cyst(s) + - Diffuse and early nodular diabetic glomerulosclerosis + - Dysplasia; high grade + - Dysplasia; low grade + - Endometrial polyp + - Endometriosis + - Endometroid carcinoma with local mucinous differentiation + - Endosalpingiosis + - Epithelial dysplasia + - Epithelial hyperplasia + - Extravascular Matrix Loops + - Gallbladder adenomyomatosis + - Glomerular disease + - Hyperkeratosis + - Inflammation + - Intestinal metaplasia + - Keratinizing dysplasia; mild + - Keratinizing dysplasia; moderate + - Keratinizing dysplasia; severe (carcinoma in situ) + - Leiomyoma + - Leiomyomata w/ degenerative changes + - Nonkeratinizing dysplasia; mild + - Nonkeratinizing dysplasia; moderate + - Nonkeratinizing dysplasia; severe (carcinoma in situ) + - Other Complex Extravascular Matrix Patterns + - PD-L1 CPS (223C LDT) - 20% + - Percent follicular component <= 10% + - Percent follicular component > 10% + - Platinum-resistant + - Pleural plaque + - Poorly Differentiated + - Pulmonary interstitial fibrosis + - Sialadenitis + - Sinonasal papilloma + - Squamous metaplasia + - Squamous papilloma; solitary + - Squamous papillomatosis + - Tubular (papillary) adenoma(s) + - Tumor has rough spikey edges + - Tumor-associated lymphoid proliferation + - Well Differentiated + - Other + enumDef: + Extravascular Matrix Loops: + $ref: + - "_terms_enum.yaml#/extravascular_matrix_loops/common" + Other Complex Extravascular Matrix Patterns: + $ref: + - "_terms_enum.yaml#/other_complex_extravascular_matrix_patterns/common" + Poorly Differentiated: + $ref: + - "_terms_enum.yaml#/poorly_differentiated/common" + Well Differentiated: + $ref: + - "_terms_enum.yaml#/well_differentiated/common" + + anaplasia_present: + $ref: + - "_terms.yaml#/anaplasia_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + anaplasia_present_type: + $ref: + - "_terms.yaml#/anaplasia_present_type/common" + enum: + - Absent + - Diffuse + - Equivocal + - Focal + - Present + - Sclerosis + - Unknown + - Not Reported + enumDef: + Present: + $ref: + - "_terms_enum.yaml#/present/pathology_detail/anaplasia_present_type" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + bone_marrow_malignant_cells: + $ref: + - "_terms.yaml#/bone_marrow_malignant_cells/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + breslow_thickness: + $ref: + - "_terms.yaml#/breslow_thickness/common" + type: number + minimum: 0 + + circumferential_resection_margin: + $ref: + - "_terms.yaml#/circumferential_resection_margin/common" + type: number + minimum: 0 + + columnar_mucosa_present: + $ref: + - "_terms.yaml#/columnar_mucosa_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + consistent_pathology_review: + $ref: + - "_terms.yaml#/consistent_pathology_review/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + days_to_pathology_detail: + description: >- + Number of days between the date used for index and the date a pathologic review + of a specific sample or slide was performed. + type: integer + maximum: 32872 + minimum: -32872 + + dysplasia_degree: + $ref: + - "_terms.yaml#/dysplasia_degree/common" + enum: + - High Grade + - Indefinite + - Low Grade + - Mild + - Moderate + - No Dysplasia + - Severe + - Unknown + - Not Reported + enumDef: + High Grade: + $ref: + - "_terms_enum.yaml#/high_grade/pathology_detail/dysplasia_degree" + Indefinite: + $ref: + - "_terms_enum.yaml#/indefinite/common" + Low Grade: + $ref: + - "_terms_enum.yaml#/low_grade/pathology_detail/dysplasia_degree" + Mild: + $ref: + - "_terms_enum.yaml#/mild/common" + Moderate: + $ref: + - "_terms_enum.yaml#/moderate/common" + No Dysplasia: + $ref: + - "_terms_enum.yaml#/no_dysplasia/common" + Severe: + $ref: + - "_terms_enum.yaml#/severe/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + dysplasia_type: + $ref: + - "_terms.yaml#/dysplasia_type/common" + enum: + - Epithelial + - Esophageal Columnar Dysplasia + - Esophageal Mucosa Columnar Dysplasia + - Keratinizing + - Nonkeratinizing + - Other + - Unknown + - Not Reported + enumDef: + Esophageal Columnar Dysplasia: + $ref: + - "_terms_enum.yaml#/esophageal_columnar_dysplasia/common" + Keratinizing: + $ref: + - "_terms_enum.yaml#/keratinizing/common" + Nonkeratinizing: + $ref: + - "_terms_enum.yaml#/nonkeratinizing/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + epithelioid_cell_percent: + $ref: + - "_terms.yaml#/epithelioid_cell_percent/common" + type: number + maximum: 100 + minimum: 0 + + epithelioid_cell_percent_range: + $ref: + - "_terms.yaml#/epithelioid_cell_percent/common" + enum: + - 0% + - 1-30% + - 31-60% + - 61-90% + - '>90%' + - Unknown + - Not Reported + + extracapsular_extension: + $ref: + - "_terms.yaml#/extracapsular_extension/common" + enum: + - Extensive + - Focal + - Unknown + - Not Reported + + extracapsular_extension_present: + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + extranodal_extension: + $ref: + - "_terms.yaml#/extranodal_extension/common" + enum: + - Gross Extension + - Microscopic Extension + - No Extranodal Extension + - Unknown + - Not Reported + + extraocular_nodule_size: + $ref: + - "_terms.yaml#/size_extraocular_nodule/common" + enum: + - <=5mm + - '>5mm' + - Unknown + - Not Reported + + extrascleral_extension: + $ref: + - "_terms.yaml#/extrascleral_extension/common" + type: boolean + + extrascleral_extension_present: + $ref: + - "_terms.yaml#/extrascleral_extension/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + + extrathyroid_extension: + $ref: + - "_terms.yaml#/extrathyroid_extension/common" + enum: + - None + - Minimal (T3) + - Moderate/Advanced (T4a) + - Very Advanced (T4b) + - Unknown + - Not Reported + enumDef: + Minimal (T3): + $ref: + - "_terms_enum.yaml#/t3/pathology_detail/extrathyroid_extension" + Moderate/Advanced (T4a): + $ref: + - "_terms_enum.yaml#/t4a/pathology_detail/extrathyroid_extension" + None: + $ref: + - "_terms_enum.yaml#/none/common" + Very Advanced (T4b): + $ref: + - "_terms_enum.yaml#/t4b/pathology_detail/extrathyroid_extension" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + greatest_tumor_dimension: + $ref: + - "_terms.yaml#/greatest_tumor_dimension/common" + type: number + minimum: 0 + + gross_tumor_weight: + $ref: + - "_terms.yaml#/gross_tumor_weight/common" + type: number + minimum: 0 + + histologic_progression_type: + $ref: + - "_terms.yaml#/histologic_progression_type/common" + enum: + - Anaplastic + - Poorly differentiated + - Unknown + - Not Reported + enumDef: + Poorly differentiated: + $ref: + - "_terms_enum.yaml#/poorly_differentiated/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + intratubular_germ_cell_neoplasia_present: + $ref: + - "_terms.yaml#/intratubular_germ_cell_neoplasia_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + + largest_extrapelvic_peritoneal_focus: + $ref: + - "_terms.yaml#/largest_extrapelvic_peritoneal_focus/common" + enum: + - Macroscopic (2cm or less) + - Macroscopic (greater than 2cm) + - Microscopic + - Unknown + - Not Reported + enumDef: + Macroscopic (2cm or less): + $ref: + - "_terms_enum.yaml#/macroscopic_2cm_or_less/common" + Macroscopic (greater than 2cm): + $ref: + - "_terms_enum.yaml#/macroscopic_greater_than_2cm/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + lymph_node_dissection_method: + $ref: + - "_terms.yaml#/lymph_node_dissection_method/common" + enum: + - Functional (Limited) Neck Dissection + - Modified Radical Neck Dissection + - Radical Neck Dissection + + lymph_node_dissection_site: + $ref: + - "_terms.yaml#/lymph_node_dissection_site/common" + enum: + - Neck, Left + - Neck, NOS + - Neck, Right + - Retroperitoneal + - Unknown + - Not Reported + + lymph_node_involved_site: + $ref: + - "_terms.yaml#/lymph_node_involved_site/common" + enum: + - Aortic + - Axillary + - Cervical + - Cervical, Central + - Cervical, Lateral + - Cervical, NOS + - Epitrochlear + - Femoral + - Hilar + - Iliac, NOS + - Iliac-common + - Iliac-external + - Inguinal + - Intra-Abdominal, NOS + - Mediastinal + - Mesenteric + - None + - Occipital + - Paraaortic + - Parotid + - Pelvis, NOS + - Popliteal + - Retroperitoneal + - Splenic + - Submandibular + - Supraclavicular + - Unknown + - Not Reported + deprecated_enum: + - Cervical + enumDef: + Axillary: + $ref: + - "_terms_enum.yaml#/axillary/common" + Cervical: + $ref: + - "_terms_enum.yaml#/cervical/common" + Epitrochlear: + $ref: + - "_terms_enum.yaml#/epitrochlear/common" + Femoral: + $ref: + - "_terms_enum.yaml#/femoral/common" + Hilar: + $ref: + - "_terms_enum.yaml#/hilar/common" + Iliac, NOS: + $ref: + - "_terms_enum.yaml#/iliac_nos/common" + Iliac-common: + $ref: + - "_terms_enum.yaml#/iliaccommon/common" + Iliac-external: + $ref: + - "_terms_enum.yaml#/iliacexternal/common" + Inguinal: + $ref: + - "_terms_enum.yaml#/inguinal/common" + Mediastinal: + $ref: + - "_terms_enum.yaml#/mediastinal/common" + Mesenteric: + $ref: + - "_terms_enum.yaml#/mesenteric/common" + None: + $ref: + - "_terms_enum.yaml#/none/common" + Occipital: + $ref: + - "_terms_enum.yaml#/occipital/common" + Paraaortic: + $ref: + - "_terms_enum.yaml#/paraaortic/common" + Parotid: + $ref: + - "_terms_enum.yaml#/parotid/common" + Popliteal: + $ref: + - "_terms_enum.yaml#/popliteal/common" + Retroperitoneal: + $ref: + - "_terms_enum.yaml#/retroperitoneal/common" + Splenic: + $ref: + - "_terms_enum.yaml#/splenic/common" + Submandibular: + $ref: + - "_terms_enum.yaml#/submandibular/common" + Supraclavicular: + $ref: + - "_terms_enum.yaml#/supraclavicular/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + lymph_node_involvement: + $ref: + - "_terms.yaml#/lymph_node_involvement/common" + enum: + - Indeterminant + - Negative + - Positive + - Unknown + - Not Reported + enumDef: + Indeterminant: + $ref: + - "_terms_enum.yaml#/indeterminant/common" + Negative: + $ref: + - "_terms_enum.yaml#/negative/common" + Positive: + $ref: + - "_terms_enum.yaml#/positive/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + lymph_nodes_positive: + $ref: + - "_terms.yaml#/lymph_nodes_positive/common" + type: integer + minimum: 0 + + lymph_nodes_removed: + $ref: + - "_terms.yaml#/lymph_nodes_removed/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + + lymph_nodes_tested: + $ref: + - "_terms.yaml#/lymph_nodes_tested/common" + type: integer + minimum: 0 + + lymphatic_invasion_present: + $ref: + - "_terms.yaml#/lymphatic_invasion_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + margin_status: + $ref: + - "_terms.yaml#/margin_status/common" + enum: + - Indeterminant + - Involved + - Uninvolved + - Unknown + - Not Reported + enumDef: + Indeterminant: + $ref: + - "_terms_enum.yaml#/indeterminant/common" + Involved: + $ref: + - "_terms_enum.yaml#/involved/common" + Uninvolved: + $ref: + - "_terms_enum.yaml#/uninvolved/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + measurement_type: + $ref: + - "_terms.yaml#/measurement_type/common" + enum: + - Echographic + - Pathologic + - Radiologic + - Unknown + - Not Reported + enumDef: + Radiologic: + $ref: + - "_terms_enum.yaml#/radiologic/common" + + measurement_unit: + $ref: + - "_terms.yaml#/measurement_unit/common" + enum: + - Centimeters + - Millimeters + - Unknown + - Not Reported + enumDef: + Centimeters: + $ref: + - "_terms_enum.yaml#/centimeters/common" + Millimeters: + $ref: + - "_terms_enum.yaml#/millimeters/common" + + metaplasia_present: + $ref: + - "_terms.yaml#/metaplasia_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + micrometastasis_present: + description: >- + Indication of metastasis in the form of small clusters of malignant cells identifiable + only under the microscope. + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + morphologic_architectural_pattern: + $ref: + - "_terms.yaml#/morphologic_architectural_pattern/common" + enum: + - Cohesive + - Cribiform + - Micropapillary + - Non-cohesive + - Papillary Renal Cell + - Papillary, NOS + - Solid + - Tubular + - Unknown + - Not Reported + enumDef: + Cribiform: + $ref: + - "_terms_enum.yaml#/cribiform/common" + Micropapillary: + $ref: + - "_terms_enum.yaml#/micropapillary/common" + Papillary Renal Cell: + $ref: + - "_terms_enum.yaml#/papillary_renal_cell/common" + Papillary, NOS: + $ref: + - "_terms_enum.yaml#/papillary_nos/common" + Solid: + $ref: + - "_terms_enum.yaml#/solid/common" + Tubular: + $ref: + - "_terms_enum.yaml#/tubular/common" + + necrosis_percent: + $ref: + - "_terms.yaml#/necrosis_percent/common" + type: number + maximum: 100 + minimum: 0 + + necrosis_present: + $ref: + - "_terms.yaml#/necrosis_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + non_nodal_regional_disease: + $ref: + - "_terms.yaml#/non_nodal_regional_disease/common" + enum: + - Absent + - Indeterminate + - Present + - Unknown + - Not Reported + enumDef: + Present: + $ref: + - "_terms_enum.yaml#/present/pathology_detail/non_nodal_regional_disease" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + non_nodal_tumor_deposits: + $ref: + - "_terms.yaml#/non_nodal_tumor_deposits/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + number_proliferating_cells: + $ref: + - "_terms.yaml#/number_proliferating_cells/common" + type: integer + minimum: 0 + + percent_tumor_invasion: + $ref: + - "_terms.yaml#/percent_tumor_invasion/common" + type: number + maximum: 100 + minimum: 0 + + percent_tumor_nuclei: + $ref: + - "_terms.yaml#/percent_tumor_nuclei/common" + type: number + maximum: 100 + minimum: 0 + + perineural_invasion_present: + $ref: + - "_terms.yaml#/perineural_invasion_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + peripancreatic_lymph_nodes_positive: + $ref: + - "_terms.yaml#/peripancreatic_lymph_nodes_positive/common" + enum: + - "0" + - 1-3 + - 4 or More + - Unknown + - Not Reported + enumDef: + "0": + $ref: + - "_terms_enum.yaml#/0/common" + 1-3: + $ref: + - "_terms_enum.yaml#/13/common" + 4 or More: + $ref: + - "_terms_enum.yaml#/4_or_more/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + peripancreatic_lymph_nodes_tested: + $ref: + - "_terms.yaml#/peripancreatic_lymph_nodes_tested/common" + type: integer + minimum: 0 + + prcc_type: + $ref: + - "_terms.yaml#/prcc_type/common" + enum: + - Type 1 + - Type 2 + - Unknown + - Not Reported + + prostatic_chips_positive_count: + $ref: + - "_terms.yaml#/prostatic_chips_positive_count/common" + type: number + minimum: 0 + + prostatic_chips_total_count: + $ref: + - "_terms.yaml#/prostatic_chips_total_count/common" + type: number + minimum: 0 + + prostatic_involvement_percent: + $ref: + - "_terms.yaml#/prostatic_involvement_percent/common" + type: number + maximum: 100 + minimum: 0 + + residual_tumor: + $ref: + - "_terms.yaml#/residual_tumor/common" + enum: + - R0 + - R1 + - R2 + - RX + - Unknown + - Not Reported + + residual_tumor_measurement: + $ref: + - "_terms.yaml#/residual_tumor_measurement/common" + enum: + - 1-10 mm + - 11-20 mm + - '>20 mm' + - No macroscopic disease + - Unknown + - Not Reported + + rhabdoid_percent: + $ref: + - "_terms.yaml#/rhabdoid_percent/common" + type: number + maximum: 100 + minimum: 0 + + rhabdoid_present: + $ref: + - "_terms.yaml#/rhabdoid_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + sarcomatoid_percent: + $ref: + - "_terms.yaml#/sarcomatoid_percent/common" + type: number + maximum: 100 + minimum: 0 + + sarcomatoid_present: + $ref: + - "_terms.yaml#/sarcomatoid_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + size_extraocular_nodule: + $ref: + - "_terms.yaml#/size_extraocular_nodule/common" + type: number + minimum: 0 + + spindle_cell_percent: + $ref: + - "_terms.yaml#/spindle_cell_percent/common" + type: number + maximum: 100 + minimum: 0 + + spindle_cell_percent_range: + $ref: + - "_terms.yaml#/spindle_cell_percent/common" + enum: + - 0% + - 1-30% + - 31-60% + - 61-90% + - '>90%' + - Unknown + - Not Reported + + timepoint_category: + $ref: + - "_terms.yaml#/timepoint_category/common" + enum: + - Adjuvant Therapy + - Adolescence + - Adulthood + - After Chemotherapy + - After Study Enrollment + - Childhood + - End of Consolidation Therapy + - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 + - First Complete Response + - First Treatment + - Follow-up + - Initial Diagnosis + - Last Contact + - Post Adjuvant Therapy + - Post Hormone Therapy + - Post Initial Treatment + - Post Secondary Therapy + - Postoperative + - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy + - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration + - Prior to Treatment + - Progression + - Recurrence + - Recurrence/Progression + - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment + - Within 3 Months of Surgery + - Other + - Unknown + - Not Reported + + transglottic_extension: + $ref: + - "_terms.yaml#/transglottic_extension/common" + enum: + - Absent + - Present + - Unknown + - Not Reported + enumDef: + Present: + $ref: + - "_terms_enum.yaml#/present/pathology_detail/transglottic_extension" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + tumor_basal_diameter: + $ref: + - "_terms.yaml#/tumor_basal_diameter/common" + type: number + minimum: 0 + + tumor_burden: + $ref: + - "_terms.yaml#/tumor_burden/common" + type: number + minimum: 0 + + tumor_depth_descriptor: + $ref: + - "_terms.yaml#/tumor_depth_descriptor/common" + enum: + - Deep + - Superficial + - Unknown + - Not Reported + enumDef: + Deep: + $ref: + - "_terms_enum.yaml#/deep/common" + Superficial: + $ref: + - "_terms_enum.yaml#/superficial/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + tumor_depth_measurement: + $ref: + - "_terms.yaml#/tumor_depth_measurement/common" + type: number + minimum: 0 + + tumor_infiltrating_lymphocytes: + $ref: + - "_terms.yaml#/tumor_infiltrating_lymphocytes/common" + enum: + - Few + - Many + - Moderate + - Unknown + - Not Reported + enumDef: + Few: + $ref: + - "_terms_enum.yaml#/few/common" + Many: + $ref: + - "_terms_enum.yaml#/many/common" + Moderate: + $ref: + - "_terms_enum.yaml#/moderate/common" + + tumor_infiltrating_macrophages: + $ref: + - "_terms.yaml#/tumor_infiltrating_macrophages/common" + enum: + - Few + - Many + - Moderate + - Unknown + - Not Reported + enumDef: + Few: + $ref: + - "_terms_enum.yaml#/few/common" + Many: + $ref: + - "_terms_enum.yaml#/many/common" + Moderate: + $ref: + - "_terms_enum.yaml#/moderate/common" + + tumor_largest_dimension_diameter: + $ref: + - "_terms.yaml#/tumor_largest_dimension_diameter/common" + type: number + minimum: 0 + + tumor_length_measurement: + $ref: + - "_terms.yaml#/tumor_length_measurement/common" + type: number + minimum: 0 + + tumor_level_prostate: + $ref: + - "_terms.yaml#/tumor_level_prostate/common" + type: array + items: + enum: + - Apex + - Base + - Middle + + tumor_shape: + $ref: + - "_terms.yaml#/tumor_shape/common" + enum: + - Diffuse + - Dome + - Mushroom + - Unknown + - Not Reported + enumDef: + Diffuse: + $ref: + - "_terms_enum.yaml#/diffuse/common" + Dome: + $ref: + - "_terms_enum.yaml#/dome/common" + Mushroom: + $ref: + - "_terms_enum.yaml#/mushroom/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + tumor_thickness: + $ref: + - "_terms.yaml#/tumor_thickness/common" + type: number + minimum: 0 + + tumor_width_measurement: + $ref: + - "_terms.yaml#/tumor_width_measurement/common" + type: number + minimum: 0 + + vascular_invasion_present: + $ref: + - "_terms.yaml#/vascular_invasion_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + vascular_invasion_type: + $ref: + - "_terms.yaml#/vascular_invasion_type/common" + enum: + - Extramural + - Intramural + - Macro + - Micro + - No Vascular Invasion + - Unknown + - Not Reported + enumDef: + No Vascular Invasion: + $ref: + - "_terms_enum.yaml#/no_vascular_invasion/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + zone_of_origin_prostate: + $ref: + - "_terms.yaml#/zone_of_origin_prostate/common" + enum: + - Central zone + - Overlapping/multiple zones + - Peripheral zone + - Transition zone + - Unknown zone + - Not Reported + + diagnoses: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/pathology_report.yaml b/server/data_files/GDC/model-3.3.0/pathology_report.yaml new file mode 100644 index 0000000..b874305 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/pathology_report.yaml @@ -0,0 +1,72 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "pathology_report" +title: Pathology Report +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing the pathology report. +additionalProperties: false +submittable: true +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: samples + backref: pathology_reports + label: derived_from + target_type: sample + multiplicity: one_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Clinical + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Pathology Report + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - PDF + + samples: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/platform.yaml b/server/data_files/GDC/model-3.3.0/platform.yaml new file mode 100644 index 0000000..c3519c5 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/platform.yaml @@ -0,0 +1,43 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "platform" +title: Platform +type: object +namespace: https://gdc.cancer.gov +category: TBD +project: '*' +program: '*' +description: >- + Any distinct technology (laboratory or computational) from which data may be obtained + as files. (GDC) (deprecated). +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: [] + +required: + - name + +uniqueKeys: + - [id] + - [name] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + + name: + description: >- + name of this platform + type: string diff --git a/server/data_files/GDC/model-3.3.0/portion.yaml b/server/data_files/GDC/model-3.3.0/portion.yaml new file mode 100644 index 0000000..34a2602 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/portion.yaml @@ -0,0 +1,77 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "portion" +title: Portion +type: object +namespace: https://gdc.cancer.gov +category: biospecimen +project: '*' +program: '*' +description: >- + A physical sub-part of any sample. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: samples + backref: portions + label: derived_from + target_type: sample + multiplicity: many_to_one + required: true + - name: centers + backref: portions + label: shipped_to + target_type: center + multiplicity: many_to_one + required: false + +required: + - submitter_id + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + creation_datetime: + $ref: + - "_terms.yaml#/creation_datetime/common" + type: number + minimum: 0 + + is_ffpe: + $ref: + - "_terms.yaml#/is_ffpe/common" + type: boolean + + portion_number: + $ref: + - "_terms.yaml#/portion_number/common" + type: string + + weight: + $ref: + - "_terms.yaml#/portion_weight/common" + type: number + minimum: 0 + + samples: + $ref: "_definitions.yaml#/to_one" + + centers: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/program.yaml b/server/data_files/GDC/model-3.3.0/program.yaml new file mode 100644 index 0000000..cab6a32 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/program.yaml @@ -0,0 +1,48 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "program" +title: Program +type: object +namespace: https://gdc.cancer.gov +category: administrative +project: '*' +program: '*' +description: >- + A broad framework of goals to be achieved. (NCIt C52647) +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: [] + +required: + - name + - dbgap_accession_number + +uniqueKeys: + - [id] + - [name] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + + name: + description: >- + Full name/title of the program. + type: string + + dbgap_accession_number: + description: >- + The dbgap accession number provided for the program. + type: string diff --git a/server/data_files/GDC/model-3.3.0/project.yaml b/server/data_files/GDC/model-3.3.0/project.yaml new file mode 100644 index 0000000..7a5ce1f --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/project.yaml @@ -0,0 +1,153 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "project" +title: Project +type: object +namespace: https://gdc.cancer.gov +category: administrative +project: '*' +program: '*' +description: >- + Any specifically defined piece of work that is undertaken or attempted to meet a + single requirement. (NCIt C47885) +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - state + - released + - releasable + - intended_release_date + +links: + - name: programs + backref: projects + label: member_of + target_type: program + multiplicity: many_to_one + required: true + +required: + - code + - name + - state + - programs + - dbgap_accession_number + +uniqueKeys: + - [id] + - [code] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + description: >- + UUID for the project + + awg_review: + description: >- + Indicates that the project is an AWG project. + type: boolean + default: false + + code: + description: >- + Project code + type: string + + dbgap_accession_number: + description: >- + The dbgap accession number for the project. + type: string + + disease_type: + description: >- + Full name for the project + type: string + + intended_release_date: + $ref: + - "_definitions.yaml#/datetime" + description: >- + Tracks a Project's intended release date. + + in_review: + description: >- + Indicates that the project is under review by the submitter. Upload and data + modification is disabled. + type: boolean + default: false + + is_legacy: + description: >- + Indicates whether a project will appear in the Legacy Archive. + type: boolean + default: false + + name: + description: >- + Display name for the project + type: string + + primary_site: + description: >- + Primary site for the project + type: string + + state: + description: >- + The possible states a project can be in. All but `open` are equivalent to some + type of locked state. + default: open + enum: + - open + - review + - submitted + - processing + - processed + - closed + - legacy + + release_requested: + description: >- + User requests that the GDC release the project. Release can only be requested + if the project is releasable. + type: boolean + default: false + + released: + description: >- + To release a project is to tell the GDC to include all submitted entities in + the next GDC index. + type: boolean + default: false + + releasable: + description: >- + A project can only be released by the user when `releasable` is true. + type: boolean + default: false + + request_submission: + description: >- + Indicates that the user has requested submission to the GDC for harmonization. + type: boolean + default: false + + submission_enabled: + description: >- + Indicates if submission to a project is allowed. + type: boolean + default: true + + programs: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/protein_expression.yaml b/server/data_files/GDC/model-3.3.0/protein_expression.yaml new file mode 100644 index 0000000..7dab770 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/protein_expression.yaml @@ -0,0 +1,98 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "protein_expression" +title: Protein Expression +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing normalized Reverse Phase Protein Array data. +additionalProperties: false +submittable: true +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: portions + backref: protein_expressions + label: derived_from + target_type: portion + multiplicity: one_to_one + required: false + - name: samples + backref: protein_expressions + label: derived_from + target_type: sample + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Proteome Profiling + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Protein Expression Quantification + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TSV + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Reverse Phase Protein Array + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - RPPA + + portions: + $ref: "_definitions.yaml#/to_one" + + samples: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/publication.yaml b/server/data_files/GDC/model-3.3.0/publication.yaml new file mode 100644 index 0000000..779ada8 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/publication.yaml @@ -0,0 +1,71 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "publication" +title: Publication +type: object +namespace: https://gdc.cancer.gov +category: TBD +project: '*' +program: '*' +description: >- + Publication for a legacy file (deprecated). +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + +links: + - name: files + backref: publications + label: refers_to + target_type: file + multiplicity: many_to_many + required: true + +required: + - pmid + - doi + - files + +uniqueKeys: + - [id] + - [pmid] + - [doi] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + + pmid: + type: string + + doi: + type: string + + project_id: + $ref: + - "_terms.yaml#/project_id/common" + type: string + + created_datetime: + $ref: + - "_definitions.yaml#/datetime" + + updated_datetime: + $ref: + - "_definitions.yaml#/datetime" + + files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/raw_methylation_array.yaml b/server/data_files/GDC/model-3.3.0/raw_methylation_array.yaml new file mode 100644 index 0000000..1af3af3 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/raw_methylation_array.yaml @@ -0,0 +1,117 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "raw_methylation_array" +title: Raw Methylation Array +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing channel data from a methylation array. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: aliquots + backref: raw_methylation_arrays + label: data_from + target_type: aliquot + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + - channel + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + channel: + $ref: + - "_terms.yaml#/channel/common" + enum: + - Green + - Red + + chip_id: + $ref: + - "_terms.yaml#/chip_id/common" + type: string + + chip_position: + $ref: + - "_terms.yaml#/chip_position/common" + type: string + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - DNA Methylation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - IDAT + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Raw Intensities + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Methylation Array + + plate_name: + $ref: + - "_terms.yaml#/plate_name/common" + type: string + + plate_well: + $ref: + - "_terms.yaml#/plate_well/common" + type: string + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Illumina Human Methylation 27 + - Illumina Human Methylation 450 + - Illumina Methylation Epic + - Illumina Methylation Epic v2 + + aliquots: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/read_group.yaml b/server/data_files/GDC/model-3.3.0/read_group.yaml new file mode 100644 index 0000000..4831d46 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/read_group.yaml @@ -0,0 +1,476 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "read_group" +title: Read Group +type: object +namespace: https://gdc.cancer.gov +category: biospecimen +project: '*' +program: '*' +description: >- + Sequencing reads from one lane of an NGS experiment. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: aliquots + backref: read_groups + label: derived_from + target_type: aliquot + multiplicity: many_to_one + required: true + +required: + - submitter_id + - aliquots + - experiment_name + - sequencing_center + - platform + - library_selection + - library_strategy + - library_name + - is_paired_end + - read_length + - read_group_name + - target_capture_kit + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - RIN + - target_capture_kit_catalog_number + - target_capture_kit_name + - target_capture_kit_target_region + - target_capture_kit_vendor + - target_capture_kit_version + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + adapter_name: + $ref: + - "_terms.yaml#/adapter_name/common" + type: string + + adapter_sequence: + $ref: + - "_terms.yaml#/adapter_sequence/common" + type: string + + base_caller_name: + $ref: + - "_terms.yaml#/base_caller_name/common" + type: string + + base_caller_version: + $ref: + - "_terms.yaml#/base_caller_version/common" + type: string + + chipseq_antibody: + $ref: + - "_terms.yaml#/chipseq_antibody/common" + enum: + - abcam ab4729 anti-H3K27ac + - Unknown + - Not Applicable + enumDef: + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + chipseq_target: + $ref: + - "_terms.yaml#/chipseq_target/common" + enum: + - H3K4me1 + - H3K4me3 + - H3K9me3 + - H3K27me3 + - H3K36me3 + - H3K27ac + - Input Control + - Unknown + + days_to_sequencing: + $ref: + - "_terms.yaml#/days_to_sequencing/common" + type: integer + minimum: -32872 + + experiment_name: + $ref: + - "_terms.yaml#/experiment_name/common" + type: string + + flow_cell_barcode: + $ref: + - "_terms.yaml#/flow_cell_barcode/common" + type: string + + fragment_maximum_length: + $ref: + - "_terms.yaml#/fragment_maximum_length/common" + type: integer + minimum: 0 + + fragment_mean_length: + $ref: + - "_terms.yaml#/fragment_mean_length/common" + type: number + minimum: 0 + + fragment_minimum_length: + $ref: + - "_terms.yaml#/fragment_minimum_length/common" + type: integer + minimum: 0 + + fragment_standard_deviation_length: + $ref: + - "_terms.yaml#/fragment_standard_deviation_length/common" + type: number + minimum: 0 + + fragmentation_enzyme: + $ref: + - "_terms.yaml#/fragmentation_enzyme/common" + enum: + - MboI + - Unknown + - Not Applicable + enumDef: + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + includes_spike_ins: + $ref: + - "_terms.yaml#/includes_spike_ins/common" + type: boolean + + instrument_model: + $ref: + - "_terms.yaml#/instrument_model/common" + enum: + - 454 GS FLX Titanium + - AB SOLiD 2 + - AB SOLiD 3 + - AB SOLiD 4 + - Complete Genomics + - Illumina Genome Analyzer II + - Illumina Genome Analyzer IIx + - Illumina HiSeq 2000 + - Illumina HiSeq 2500 + - Illumina HiSeq 4000 + - Illumina HiSeq X Five + - Illumina HiSeq X Ten + - Illumina MiSeq + - Illumina NextSeq + - Illumina NovaSeq 6000 + - Illumina NovaSeq X + - Ion Torrent PGM + - Ion Torrent Proton + - Ion Torrent S5 + - Other + - PacBio RS + - Unknown + - Not Reported + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + is_paired_end: + $ref: + - "_terms.yaml#/is_paired_end/common" + oneOf: + - type: boolean + - type: "null" + + lane_number: + $ref: + - "_terms.yaml#/lane_number/common" + type: integer + minimum: 1 + + library_name: + $ref: + - "_terms.yaml#/library_name/common" + type: string + + library_preparation_kit_name: + $ref: + - "_terms.yaml#/library_preparation_kit_name/common" + type: string + + library_preparation_kit_vendor: + $ref: + - "_terms.yaml#/library_preparation_kit_vendor/common" + type: string + + library_preparation_kit_catalog_number: + $ref: + - "_terms.yaml#/library_preparation_kit_catalog_number/common" + type: string + + library_preparation_kit_version: + $ref: + - "_terms.yaml#/library_preparation_kit_version/common" + type: string + + library_selection: + $ref: + - "_terms.yaml#/library_selection/common" + enum: + - Affinity Enrichment + - Hybrid Selection + - miRNA Size Fractionation + - Other + - PCR + - Poly-T Enrichment + - Random + - rRNA Depletion + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + PCR: + $ref: + - "_terms_enum.yaml#/pcr/common" + + library_strand: + $ref: + - "_terms.yaml#/library_strand/common" + enum: + - Unstranded + - First_Stranded + - Second_Stranded + - Not Applicable + enumDef: + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + library_strategy: + $ref: + - "_terms.yaml#/library_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - HiChIP + - m6A MeRIP-Seq + - miRNA-Seq + - RNA-Seq + - scATAC-Seq + - scRNA-Seq + - Targeted Sequencing + - WGS + - WXS + enumDef: + Targeted Sequencing: + $ref: + - "_terms_enum.yaml#/targeted_sequencing/common" + WGS: + $ref: + - "_terms_enum.yaml#/wgs/common" + WXS: + $ref: + - "_terms_enum.yaml#/wxs/common" + + multiplex_barcode: + $ref: + - "_terms.yaml#/multiplex_barcode/common" + type: string + pattern: "^[0-9ACGTURYSWKMBDHVN]+([\\+\\-][0-9ACGTURYSWKMBDHVN]+){,2}$" + + number_expect_cells: + $ref: + - "_terms.yaml#/number_expect_cells/common" + type: integer + minimum: 0 + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Complete Genomics + - Illumina + - Ion Torrent + - LS454 + - Other + - PacBio + - SOLiD + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + + read_group_name: + description: >- + Read Group Name + type: string + + read_length: + $ref: + - "_terms.yaml#/read_length/common" + oneOf: + - type: integer + minimum: 0 + - type: "null" + + rin: + $ref: + - "_terms.yaml#/rin/common" + type: number + maximum: 10 + minimum: 1 + + sequencing_center: + $ref: + - "_terms.yaml#/sequencing_center/common" + type: string + + sequencing_date: + $ref: + - "_definitions.yaml#/datetime" + + size_selection_range: + $ref: + - "_terms.yaml#/size_selection_range/common" + type: string + + single_cell_library: + $ref: + - "_terms.yaml#/single_cell_library/common" + enum: + - Chromium 3' Gene Expression v2 Library + - Chromium 3' Gene Expression v3 Library + - Chromium scATAC v1 Library + - Smart-Seq2 + + spike_ins_concentration: + $ref: + - "_terms.yaml#/spike_ins_concentration/common" + type: string + + spike_ins_fasta: + $ref: + - "_terms.yaml#/spike_ins_fasta/common" + type: string + + target_capture_kit: + $ref: + - "_terms.yaml#/target_capture_kit/common" + enum: + - Custom AmpliSeq Cancer Hotspot GENIE-MDA Augmented Panel v1 - 46 Genes + - Custom GENIE-DFCI OncoPanel - 275 Genes + - Custom GENIE-DFCI Oncopanel - 300 Genes + - Custom GENIE-DFCI Oncopanel - 447 Genes + - Custom HaloPlex DLBCL Panel - 370 Genes + - Custom Ion AmpliSeq Hotspot GENIE-MOSC3 Augmented Panel - 74 Genes + - Custom Large Construct Capture TARGET-OS Panel - 8 Genes + - Custom MSK IMPACT Panel - 341 Genes + - Custom MSK IMPACT Panel - 410 Genes + - Custom MSK IMPACT Panel - 468 Genes + - Custom Myeloid GENIE-VICC Panel - 37 Genes + - Custom Personalis ACEcp VAREPOP-APOLLO Panel v2 + - Custom PGDX SureSelect CancerSelect VAREPOP-APOLLO Panel - 203 Genes + - Custom PGDX SureSelect CancerSelect VAREPOP-APOLLO Panel - 88 Genes + - Custom SeqCap EZ BeatAML Panel - 12.5 Mb + - Custom SeqCap EZ HGSC VCRome v2.1 ER Augmented v1 + - Custom SeqCap EZ HGSC VCRome v2.1 ER Augmented v2 + - Custom SeqCap EZ TARGET-OS Panel - 7.0 Mb + - Custom Solid Tumor GENIE-VICC Panel - 34 Genes + - Custom SureSelect CGCI-BLGSP Panel - 4.6 Mb + - Custom SureSelect CGCI-BLGSP Panel - 7.8 Mb + - Custom SureSelect CGCI-HTMCP-CC KMT2D And Hotspot Panel - 37.0 Kb + - Custom SureSelect CGCI-HTMCP-CC Panel - 19.7 Mb + - Custom SureSelect GENIE-UHN Panel - 555 Genes + - Custom SureSelect Human All Exon v1.1 Plus 3 Boosters + - Custom SureSelect TARGET-AML_NBL_WT Panel - 2.8 Mb + - Custom Twist Broad Exome v1.0 - 35.0 Mb + - Custom Twist Broad PanCancer Panel - 396 Genes + - Custom Twist MP2PRT-WT Panel - 52 Kb + - Foundation Medicine T5a Panel - 322 Genes + - Foundation Medicine T7 Panel - 429 Genes + - Ion AmpliSeq Cancer Hotspot Panel v2 + - Ion AmpliSeq Comprehensive Cancer Panel + - Nextera DNA Exome + - Nextera Rapid Capture Exome v1.2 + - Not Applicable + - SeqCap EZ HGSC VCRome v2.1 + - SeqCap EZ Human Exome v2.0 + - SeqCap EZ Human Exome v3.0 + - SureSelect Human All Exon v3 + - SureSelect Human All Exon v4 + - SureSelect Human All Exon v5 + - SureSelect Human All Exon v5 + UTR + - TruSeq Amplicon Cancer Panel + - TruSeq Exome Enrichment - 62 Mb + - TruSeq RNA Exome + - TruSight Myeloid Sequencing Panel + - Twist Human Comprehensive Exome + - xGen Exome Research Panel v1.0 + - Unknown + enumDef: + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + + target_capture_kit_catalog_number: + $ref: + - "_terms.yaml#/target_capture_kit_catalog_number/common" + type: string + + target_capture_kit_name: + $ref: + - "_terms.yaml#/target_capture_kit_name/common" + type: string + + target_capture_kit_target_region: + $ref: + - "_terms.yaml#/target_capture_kit_target_region/common" + type: string + + target_capture_kit_vendor: + $ref: + - "_terms.yaml#/target_capture_kit_vendor/common" + type: string + + target_capture_kit_version: + $ref: + - "_terms.yaml#/target_capture_kit_version/common" + type: string + + to_trim_adapter_sequence: + $ref: + - "_terms.yaml#/to_trim_adapter_sequence/common" + type: boolean + + aliquots: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/read_group_qc.yaml b/server/data_files/GDC/model-3.3.0/read_group_qc.yaml new file mode 100644 index 0000000..e81d308 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/read_group_qc.yaml @@ -0,0 +1,144 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "read_group_qc" +title: Read Group QC +type: object +namespace: https://gdc.cancer.gov +category: notation +project: '*' +program: '*' +description: >- + GDC QC run metadata. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: true + required: true + subgroup: + - name: submitted_aligned_reads_files + backref: read_group_qcs + label: data_from + target_type: submitted_aligned_reads + multiplicity: one_to_one + required: false + - name: submitted_unaligned_reads_files + backref: read_group_qcs + label: data_from + target_type: submitted_unaligned_reads + multiplicity: one_to_many + required: false + - name: read_groups + backref: read_group_qcs + label: generated_from + target_type: read_group + multiplicity: many_to_one + required: true + +required: + - submitter_id + - workflow_link + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + adapter_content: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + basic_statistics: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + encoding: + $ref: + - "_terms.yaml#/encoding/common" + type: string + + fastq_name: + $ref: + - "_terms.yaml#/file_name/common" + type: string + + kmer_content: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + overrepresented_sequences: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + per_base_sequence_quality: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + per_tile_sequence_quality: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + per_sequence_quality_score: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + per_base_sequence_content: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + per_sequence_gc_content: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + per_base_n_content: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + percent_gc_content: + $ref: + - "_terms.yaml#/percent_gc_content/common" + type: integer + maximum: 100 + minimum: 0 + + sequence_length_distribution: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + sequence_duplication_levels: + $ref: + - "_definitions.yaml#/qc_metrics_state" + + total_sequences: + $ref: + - "_terms.yaml#/total_sequences/common" + type: integer + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - Read Group Quality Control + + submitted_aligned_reads_files: + $ref: "_definitions.yaml#/to_one" + + submitted_unaligned_reads_files: + $ref: "_definitions.yaml#/to_many" + + read_groups: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/rna_expression_workflow.yaml b/server/data_files/GDC/model-3.3.0/rna_expression_workflow.yaml new file mode 100644 index 0000000..f4edea2 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/rna_expression_workflow.yaml @@ -0,0 +1,102 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "rna_expression_workflow" +title: RNA Expression Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the RNA expression pipeline used to quantify RNA gene and exon expression + from unharmonized or GDC harmonized data. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: true + required: true + subgroup: + - name: aligned_reads_files + backref: rna_expression_workflows + label: performed_on + target_type: aligned_reads + multiplicity: many_to_one + required: false + - name: submitted_aligned_reads_files + backref: rna_expression_workflows + label: performed_on + target_type: submitted_aligned_reads + multiplicity: many_to_one + required: false + - name: submitted_unaligned_reads_files + backref: rna_expression_workflows + label: performed_on + target_type: submitted_unaligned_reads + multiplicity: many_to_one + required: false + - name: submitted_expression_arrays + backref: rna_expression_workflows + label: performed_on + target_type: submitted_expression_array + multiplicity: many_to_many + required: false + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - CellRanger - 10x Filtered Counts + - CellRanger - 10x Raw Counts + - Cufflinks + - DEXSeq + - Expression Array Quantification + - HTSeq - Counts + - HTSeq - FPKM + - HTSeq - FPKM-UQ + - Kallisto - HDF5 + - Kallisto - Quantification + - RNA-SeQC - Counts + - RNA-SeQC - FPKM + - RSEM - Quantification + - STAR - Counts + - STAR - FPKM + - STAR - Smart-Seq2 Filtered Counts + - STAR - Smart-Seq2 Raw Counts + - zUMIs - Smart-Seq2 Counts + + aligned_reads_files: + $ref: "_definitions.yaml#/to_one" + + submitted_aligned_reads_files: + $ref: "_definitions.yaml#/to_one" + + submitted_unaligned_reads_files: + $ref: "_definitions.yaml#/to_one" + + submitted_expression_arrays: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/root.yaml b/server/data_files/GDC/model-3.3.0/root.yaml new file mode 100644 index 0000000..3b943e9 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/root.yaml @@ -0,0 +1,40 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "root" +title: Root +type: object +namespace: https://gdc.cancer.gov +category: data +project: '*' +program: '*' +description: >- + This is the GDC root node. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null +root: '*' + +systemProperties: + - id + +links: [] + +required: + - type + +uniqueKeys: + - [id] + +properties: + + type: + type: string + + id: + enum: + - "root" + + schema_version: + type: string diff --git a/server/data_files/GDC/model-3.3.0/run_metadata.yaml b/server/data_files/GDC/model-3.3.0/run_metadata.yaml new file mode 100644 index 0000000..436a103 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/run_metadata.yaml @@ -0,0 +1,85 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "run_metadata" +title: Run Metadata +type: object +namespace: https://gdc.cancer.gov +category: metadata_file +project: '*' +program: '*' +description: >- + Data file containing the run information from the SRA XML. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: read_groups + backref: run_metadata_files + label: derived_from + target_type: read_group + multiplicity: many_to_one + required: false + - name: files + backref: run_metadata_files + label: derived_from + target_type: file + multiplicity: one_to_many + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Sequencing Data + - Raw Sequencing Data + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Run Metadata + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - SRA XML + + read_groups: + $ref: "_definitions.yaml#/to_one" + + files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/sample.yaml b/server/data_files/GDC/model-3.3.0/sample.yaml new file mode 100644 index 0000000..10d9689 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/sample.yaml @@ -0,0 +1,1101 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "sample" +title: Sample +type: object +namespace: https://gdc.cancer.gov +category: biospecimen +project: '*' +program: '*' +description: >- + Any material sample taken from a biological entity for testing, diagnostic, propagation, + treatment or research purposes, including a sample obtained from a living organism + or taken from the biological object after halting of all its life functions. Biospecimen + can contain one or more components including but not limited to cellular molecules, + cells, tissues, organs, body fluids, embryos, and body excretory products. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: cases + backref: samples + label: derived_from + target_type: case + multiplicity: many_to_one + required: true + - name: tissue_source_sites + backref: samples + label: processed_at + target_type: tissue_source_site + multiplicity: one_to_one + required: false + - name: diagnoses + backref: samples + label: related_to + target_type: diagnosis + multiplicity: many_to_one + required: false + - name: parent_samples + backref: child_samples + label: derived_from + target_type: sample + multiplicity: many_to_one + required: false + +required: + - preservation_method + - specimen_type + - submitter_id + - tissue_type + - tumor_descriptor + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - composition + - is_ffpe + - oct_embedded + - sample_type + - sample_type_id + - tumor_code + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + biospecimen_anatomic_site: + $ref: + - "_terms.yaml#/biospecimen_anatomic_site/common" + enum: + - Abdomen + - Abdominal Wall + - Acetabulum + - Adenoid + - Adipose + - Adrenal + - Alveolar Ridge + - Amniotic Fluid + - Ampulla Of Vater + - Anal Sphincter + - Ankle + - Anorectum + - Antecubital Fossa + - Antrum + - Anus + - Aorta + - Aortic Body + - Appendix + - Aqueous Fluid + - Arm + - Artery + - Ascending Colon + - Ascending Colon Hepatic Flexure + - Auditory Canal + - Autonomic Nervous System + - Axilla + - Back + - Bile Duct + - Bladder + - Blood + - Blood Vessel + - Bone + - Bone Marrow + - Bowel + - Brain + - Brain Stem + - Brainstem + - Breast + - Broad Ligament + - Bronchiole + - Bronchus + - Brow + - Buccal Cavity + - Buccal Mucosa + - Buttock + - Calf + - Capillary + - Cardia + - Carina + - Carotid Artery + - Carotid Body + - Cartilage + - Cecum + - Cell-Line + - Central Nervous System + - Cerebellum + - Cerebral Cortex + - Cerebrospinal Fluid + - Cerebrum + - Cervical Spine + - Cervix + - Chest + - Chest Wall + - Chin + - Clavicle + - Clitoris + - Colon + - Colon - Mucosa Only + - Common Bile Duct + - Common Duct + - Conjunctiva + - Connective Tissue + - Dermal + - Descending Colon + - Diaphragm + - Duodenum + - Ear + - Ear Canal + - Ear, Pinna (External) + - Effusion + - Elbow + - Endocrine Gland + - Epididymis + - Epidural Space + - Esophageal; Distal + - Esophageal; Mid + - Esophageal; Proximal + - Esophagogastric Junction + - Esophagus + - Esophagus - Mucosa Only + - Eye + - Fallopian Tube + - Femoral Artery + - Femoral Vein + - Femur + - Fibroblasts + - Fibula + - Finger + - Floor Of Mouth + - Fluid + - Foot + - Forearm + - Forehead + - Foreskin + - Frontal Cortex + - Frontal Lobe + - Fundus Of Stomach + - Gallbladder + - Ganglia + - Gastroesophageal Junction + - Gastrointestinal Tract + - Glottis + - Groin + - Gum + - Hand + - Hard Palate + - Head & Neck + - Head - Face Or Neck, Nos + - Head, Face or Neck, NOS + - Heart + - Hepatic + - Hepatic Duct + - Hepatic Flexure + - Hepatic Vein + - Hip + - Hippocampus + - Humerus + - Hypopharynx + - Ileum + - Ilium + - Index Finger + - Ischium + - Islet Cells + - Jaw + - Jejunum + - Joint + - Kidney + - Knee + - Lacrimal Gland + - Large Bowel + - Laryngopharynx + - Larynx + - Leg + - Leptomeninges + - Ligament + - Lip + - Liver + - Lumbar Spine + - Lung + - Lymph Node + - Lymph Node(s) Axilla + - Lymph Node(s) Cervical + - Lymph Node(s) Distant + - Lymph Node(s) Epitrochlear + - Lymph Node(s) Femoral + - Lymph Node(s) Hilar + - Lymph Node(s) Iliac-Common + - Lymph Node(s) Iliac-External + - Lymph Node(s) Inguinal + - Lymph Node(s) Internal Mammary + - Lymph Node(s) Mammary + - Lymph Node(s) Mesenteric + - Lymph Node(s) Occipital + - Lymph Node(s) Paraaortic + - Lymph Node(s) Parotid + - Lymph Node(s) Pelvic + - Lymph Node(s) Popliteal + - Lymph Node(s) Regional + - Lymph Node(s) Retroperitoneal + - Lymph Node(s) Scalene + - Lymph Node(s) Splenic + - Lymph Node(s) Subclavicular + - Lymph Node(s) Submandibular + - Lymph Node(s) Supraclavicular + - Lymph Nodes(s) Mediastinal + - Mandible + - Maxilla + - Mediastinal Soft Tissue + - Mediastinum + - Mesentery + - Mesothelium + - Middle Finger + - Mitochondria + - Muscle + - Nails + - Nasal Cavity + - Nasal Soft Tissue + - Nasopharynx + - Neck + - Nerve + - Nerve(s) Cranial + - Occipital Cortex + - Ocular Orbits + - Omentum + - Oral Cavity + - Oral Cavity - Mucosa Only + - Oropharynx + - Ovary + - Palate + - Pancreas + - Paranasal Sinuses + - Paraspinal Ganglion + - Parathyroid + - Parotid Gland + - Patella + - Pelvis + - Penis + - Pericardium + - Periorbital Soft Tissue + - Peritoneal Cavity + - Peritoneum + - Pharynx + - Pineal + - Pineal Gland + - Pituitary Gland + - Placenta + - Pleura + - Popliteal Fossa + - Prostate + - Pylorus + - Rectosigmoid Junction + - Rectum + - Retina + - Retro-Orbital Region + - Retroperitoneum + - Rib + - Ring Finger + - Round Ligament + - Sacrum + - Salivary Gland + - Scalp + - Scapula + - Sciatic Nerve + - Scrotum + - Seminal Vesicle + - Shoulder + - Sigmoid Colon + - Sinus + - Sinus(es), Maxillary + - Skeletal Muscle + - Skin + - Skull + - Small Bowel + - Small Bowel - Mucosa Only + - Small Finger + - Soft Tissue + - Spinal Column + - Spinal Cord + - Spleen + - Splenic Flexure + - Sternum + - Stomach + - Stomach - Mucosa Only + - Subcutaneous Tissue + - Subglottis + - Sublingual Gland + - Submandibular Gland + - Supraglottis + - Synovium + - Temporal Cortex + - Tendon + - Testis + - Thigh + - Thoracic Spine + - Thorax + - Throat + - Thumb + - Thymus + - Thyroid + - Tibia + - Tongue + - Tonsil + - Tonsil (Pharyngeal) + - Trachea / Major Bronchi + - Transverse Colon + - Trunk + - Umbilical Cord + - Ureter + - Urethra + - Urinary Tract + - Uterus + - Uvula + - Vagina + - Vas Deferens + - Vein + - Venous + - Vertebra + - Vulva + - White Blood Cells + - Wrist + - Other + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Brain Stem + - Common Duct + - Head - Face Or Neck, Nos + enumDef: + Bone Marrow: + $ref: + - "_terms_enum.yaml#/bone_marrow/common" + Buccal Mucosa: + $ref: + - "_terms_enum.yaml#/buccal_mucosa/common" + Cerebrospinal Fluid: + $ref: + - "_terms_enum.yaml#/cerebrospinal_fluid/common" + Connective Tissue: + $ref: + - "_terms_enum.yaml#/connective_tissue/common" + Frontal Lobe: + $ref: + - "_terms_enum.yaml#/frontal_lobe/common" + Neck: + $ref: + - "_terms_enum.yaml#/neck/common" + Soft Tissue: + $ref: + - "_terms_enum.yaml#/soft_tissue/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + biospecimen_laterality: + $ref: + - "_terms.yaml#/biospecimen_laterality/common" + enum: + - Bilateral + - Left + - Right + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + catalog_reference: + $ref: + - "_terms.yaml#/catalog_reference/common" + type: string + + composition: + $ref: + - "_terms.yaml#/composition/common" + enum: + - 2D Classical Conditionally Reprogrammed Cells + - 2D Modified Conditionally Reprogrammed Cells + - 3D Air-Liquid Interface Organoid + - 3D Neurosphere + - 3D Organoid + - Adherent Cell Line + - Bone Marrow Components + - Bone Marrow Components NOS + - Buccal Cells + - Buffy Coat + - Cell + - Control Analyte + - Derived Cell Line + - EBV Immortalized + - Fibroblasts from Bone Marrow Normal + - Granulocytes + - Human Original Cells + - Liquid Suspension Cell Line + - Lymphocytes + - Mixed Adherent Suspension + - Mononuclear Cells from Bone Marrow Normal + - Peripheral Blood Components NOS + - Peripheral Whole Blood + - Plasma + - Pleural Effusion + - Saliva + - Serum + - Solid Tissue + - Sorted Cells + - Sputum + - Whole Bone Marrow + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + Buffy Coat: + $ref: + - "_terms_enum.yaml#/buffy_coat/common" + Lymphocytes: + $ref: + - "_terms_enum.yaml#/lymphocytes/common" + Plasma: + $ref: + - "_terms_enum.yaml#/plasma/common" + Saliva: + $ref: + - "_terms_enum.yaml#/saliva/common" + Serum: + $ref: + - "_terms_enum.yaml#/serum/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + current_weight: + $ref: + - "_terms.yaml#/current_weight/common" + type: number + minimum: 0 + + days_to_collection: + $ref: + - "_terms.yaml#/days_to_collection/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_sample_procurement: + $ref: + - "_terms.yaml#/days_to_sample_procurement/common" + type: integer + maximum: 32872 + minimum: -32872 + + diagnosis_pathologically_confirmed: + $ref: + - "_terms.yaml#/diagnosis_pathologically_confirmed/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + distance_normal_to_tumor: + $ref: + - "_terms.yaml#/distance_normal_to_tumor/common" + enum: + - Adjacent (< or = 2cm) + - Distal (>2cm) + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + distributor_reference: + $ref: + - "_terms.yaml#/distributor_reference/common" + type: string + + freezing_method: + $ref: + - "_terms.yaml#/freezing_method/common" + type: string + + growth_rate: + $ref: + - "_terms.yaml#/growth_rate/common" + type: integer + minimum: 0 + + initial_weight: + $ref: + - "_terms.yaml#/initial_weight/common" + type: number + minimum: 0 + + intermediate_dimension: + $ref: + - "_terms.yaml#/intermediate_dimension/common" + type: number + minimum: 0 + + is_ffpe: + $ref: + - "_terms.yaml#/is_ffpe/common" + type: boolean + + longest_dimension: + $ref: + - "_terms.yaml#/longest_dimension/common" + type: number + minimum: 0 + + method_of_sample_procurement: + $ref: + - "_terms.yaml#/method_of_sample_procurement/common" + enum: + - Abdomino-perineal Resection of Rectum + - Anterior Resection of Rectum + - Ascites Drainage + - Aspirate + - Autopsy + - Biopsy + - Blood Draw + - Bone Marrow Aspirate + - Buccal Mucosal Resection + - Core Biopsy + - Cystectomy + - Deep Parotidectomy + - Endo Rectal Tumor Resection + - Endolaryngeal Excision + - Endoscopic Biopsy + - Endoscopic Mucosal Resection (EMR) + - Enucleation + - Excisional Biopsy + - Fine Needle Aspiration + - Full Hysterectomy + - Glossectomy + - Gross Total Resection + - Hand Assisted Laparoscopic Radical Nephrectomy + - Hysterectomy NOS + - Incisional Biopsy + - Indeterminant + - Indeterminate + - Laparoscopic Biopsy + - Laparoscopic Partial Nephrectomy + - Laparoscopic Radical Nephrectomy + - Laparoscopic Radical Prostatectomy with Robotics + - Laparoscopic Radical Prostatectomy without Robotics + - Laryngopharyngectomy + - Left Hemicolectomy + - Liquid Biopsy + - Lobectomy + - Local Resection (Exoresection; wall resection) + - Lumpectomy + - Lymph Node Dissection + - Lymphadenectomy + - Mandibulectomy + - Maxillectomy + - Metastasectomy + - Modified Radical Mastectomy + - Needle Biopsy + - Omentectomy + - Oophorectomy + - Open Craniotomy + - Open Partial Nephrectomy + - Open Radical Nephrectomy + - Open Radical Prostatectomy + - Orchiectomy + - Other Surgical Resection + - Palatectomy + - Pan-Procto Colectomy + - Pancreatectomy + - Paracentesis + - Parotidectomy, NOS + - Partial Hepatectomy + - Partial Laryngectomy + - Partial Maxillectomy + - Partial Nephrectomy + - Peritoneal Lavage + - Pneumonectomy + - Punch Biopsy + - Radical Hysterectomy + - Radical Maxillectomy + - Radical Nephrectomy + - Radical Prostatectomy + - Right Hemicolectomy + - Salpingectomy + - Salpingo-oophorectomy + - Sigmoid Colectomy + - Simple Hysterectomy + - Simple Mastectomy + - Subtotal Prostatectomy + - Subtotal Resection + - Superficial Parotidectomy + - Supracervical Hysterectomy + - Supracricoid Laryngectomy + - Supraglottic Laryngectomy + - Surgical Resection + - Thoracentesis + - Thoracoscopic Biopsy + - Tonsillectomy + - Total Colectomy + - Total Hepatectomy + - Total Laryngectomy + - Total Mastectomy + - Total Nephrectomy + - Transoral Laser Excision + - Transplant + - Transurethral resection (TURBT) + - Transurethral Resection (TURP) + - Transverse Colectomy + - Tumor Debulking + - Tumor Resection + - Vertical Hemilaryngectomy + - Wedge Resection + - Whipple Procedure + - Other + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Indeterminant + enumDef: + Autopsy: + $ref: + - "_terms_enum.yaml#/autopsy/common" + Indeterminant: + $ref: + - "_terms_enum.yaml#/indeterminant/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + oct_embedded: + $ref: + - "_terms.yaml#/oct_embedded/common" + type: string + + passage_count: + $ref: + - "_terms.yaml#/passage_count/common" + type: integer + minimum: 0 + + pathology_report_uuid: + description: >- + UUID of the related pathology report. + type: string + + preservation_method: + $ref: + - "_terms.yaml#/preservation_method/common" + enum: + - Cryopreserved + - EDTA + - FFPE + - Fresh + - Frozen + - OCT + - Snap Frozen + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + sample_ordinal: + $ref: + - "_terms.yaml#/sample_ordinal/common" + type: integer + minimum: 1 + + sample_type: + $ref: + - "_terms.yaml#/sample_type/common" + enum: + - Additional - New Primary + - Additional Metastatic + - Benign Neoplasms + - Blood Derived Cancer - Bone Marrow + - Blood Derived Cancer - Bone Marrow, Post-treatment + - Blood Derived Cancer - Peripheral Blood + - Blood Derived Cancer - Peripheral Blood, Post-treatment + - Blood Derived Liquid Biopsy + - Blood Derived Normal + - Bone Marrow Normal + - Buccal Cell Normal + - Cell Line Derived Xenograft Tissue + - Cell Lines + - Control Analyte + - DNA + - EBV Immortalized Normal + - Expanded Next Generation Cancer Model + - FFPE Recurrent + - FFPE Scrolls + - Fibroblasts from Bone Marrow Normal + - GenomePlex (Rubicon) Amplified DNA + - Granulocytes + - Human Tumor Original Cells + - In Situ Neoplasms + - Lymphoid Normal + - Metastatic + - Mixed Adherent Suspension + - Mononuclear Cells from Bone Marrow Normal + - Neoplasms of Uncertain and Unknown Behavior + - Next Generation Cancer Model + - Next Generation Cancer Model Expanded Under Non-conforming Conditions + - Pleural Effusion + - Post neo-adjuvant therapy + - Primary Blood Derived Cancer - Bone Marrow + - Primary Blood Derived Cancer - Peripheral Blood + - Primary Tumor + - Primary Xenograft Tissue + - Recurrent Blood Derived Cancer - Bone Marrow + - Recurrent Blood Derived Cancer - Peripheral Blood + - Recurrent Tumor + - Repli-G (Qiagen) DNA + - Repli-G X (Qiagen) DNA + - RNA + - Saliva + - Slides + - Solid Tissue Normal + - Total RNA + - Tumor + - Tumor Adjacent Normal - Post Neo-adjuvant Therapy + - Xenograft Tissue + - Unknown + - Not Reported + - Not Allowed To Collect + enumDef: + DNA: + $ref: + - "_terms_enum.yaml#/dna/common" + Saliva: + $ref: + - "_terms_enum.yaml#/saliva/common" + Total RNA: + $ref: + - "_terms_enum.yaml#/total_rna/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + sample_type_id: + $ref: + - "_terms.yaml#/sample_type_id/common" + enum: + - "01" + - "02" + - "03" + - "04" + - "05" + - "06" + - "07" + - "08" + - "09" + - "10" + - "11" + - "12" + - "13" + - "14" + - "15" + - "16" + - "17" + - "18" + - "20" + - "30" + - "31" + - "32" + - "40" + - "41" + - "42" + - "50" + - "60" + - "61" + - "85" + - "86" + - "87" + - "99" + + shortest_dimension: + $ref: + - "_terms.yaml#/shortest_dimension/common" + type: number + minimum: 0 + + specimen_type: + $ref: + - "_terms.yaml#/specimen_type/common" + enum: + - 2D Classical Conditionally Reprogrammed Cells + - 2D Modified Conditionally Reprogrammed Cells + - 3D Air-Liquid Interface Organoid + - 3D Neurosphere + - 3D Organoid + - Adherent Cell Line + - Bone Marrow Components NOS + - Bone Marrow NOS + - Buccal Cells + - Buffy Coat + - Cell + - Control Analyte + - Derived Cell Line + - Derived Cell Lines and Sorted Cells + - EBV Immortalized + - Fibroblasts from Bone Marrow + - Granulocytes + - Human Original Cells + - Liquid Suspension Cell Line + - Lymphocytes + - Lymphoid + - Mixed Adherent Suspension + - Mononuclear Cells from Bone Marrow + - Peripheral Blood Components NOS + - Peripheral Blood NOS + - Peripheral Whole Blood + - Plasma + - Pleural Effusion + - Saliva + - Serum + - Solid Tissue + - Sorted Cells + - Sputum + - Whole Bone Marrow + - Unknown + - Not Reported + + time_between_clamping_and_freezing: + $ref: + - "_terms.yaml#/time_between_clamping_and_freezing/common" + type: number + minimum: 0 + + time_between_excision_and_freezing: + $ref: + - "_terms.yaml#/time_between_excision_and_freezing/common" + type: number + minimum: 0 + + tissue_collection_type: + $ref: + - "_terms.yaml#/tissue_collection_type/common" + enum: + - Prospective + - Retrospective + + tissue_type: + $ref: + - "_terms.yaml#/tissue_type/common" + enum: + - Abnormal + - Normal + - Peritumoral + - Tumor + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + Normal: + $ref: + - "_terms_enum.yaml#/normal/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + tumor_code: + $ref: + - "_terms.yaml#/tumor_code/common" + enum: + - Acute Leukemia of Ambiguous Lineage (ALAL) + - Acute lymphoblastic leukemia (ALL) + - Acute myeloid leukemia (AML) + - Anal Cancer (all types) + - Cervical Cancer (all types) + - Clear cell sarcoma of the kidney (CCSK) + - CNS, ependymoma + - CNS, glioblastoma (GBM) + - CNS, low grade glioma (LGG) + - CNS, medulloblastoma + - CNS, other + - CNS, rhabdoid tumor + - Diffuse Large B-Cell Lymphoma (DLBCL) + - Ewing sarcoma + - Induction Failure AML (AML-IF) + - Lung Cancer (all types) + - Neuroblastoma (NBL) + - NHL, anaplastic large cell lymphoma + - NHL, Burkitt lymphoma (BL) + - Non cancerous tissue + - Osteosarcoma (OS) + - Rhabdoid tumor (kidney) (RT) + - Rhabdomyosarcoma + - Soft tissue sarcoma, non-rhabdomyosarcoma + - Wilms tumor (WT) + enumDef: + Ewing sarcoma: + $ref: + - "_terms_enum.yaml#/ewing_sarcoma/common" + Rhabdomyosarcoma: + $ref: + - "_terms_enum.yaml#/rhabdomyosarcoma/common" + + tumor_code_id: + $ref: + - "_terms.yaml#/tumor_code_id/common" + enum: + - "00" + - "01" + - "02" + - "03" + - "04" + - "10" + - "15" + - "20" + - "21" + - "30" + - "40" + - "41" + - "50" + - "51" + - "52" + - "60" + - "61" + - "62" + - "63" + - "64" + - "65" + - "70" + - "71" + - "80" + - "81" + + tumor_descriptor: + $ref: + - "_terms.yaml#/tumor_descriptor/common" + enum: + - Metastatic + - New Primary + - NOS + - Premalignant + - Primary + - Recurrence + - Xenograft + - Unknown + - Not Reported + - Not Applicable + - Not Allowed To Collect + deprecated_enum: + - Not Allowed To Collect + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + cases: + $ref: "_definitions.yaml#/to_one" + + tissue_source_sites: + $ref: "_definitions.yaml#/to_one" + + diagnoses: + $ref: "_definitions.yaml#/to_one" + + parent_samples: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/secondary_expression_analysis.yaml b/server/data_files/GDC/model-3.3.0/secondary_expression_analysis.yaml new file mode 100644 index 0000000..9f5dded --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/secondary_expression_analysis.yaml @@ -0,0 +1,88 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "secondary_expression_analysis" +title: Secondary Expression Analysis +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing secondary analysis results from gene expression data. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: expression_analysis_workflows + backref: secondary_expression_analyses + label: data_from + target_type: expression_analysis_workflow + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Transcriptome Profiling + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - HDF5 + - TSV + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Differential Gene Expression + - Single Cell Analysis + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - scRNA-Seq + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Illumina + - Other + + expression_analysis_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/simple_germline_variation.yaml b/server/data_files/GDC/model-3.3.0/simple_germline_variation.yaml new file mode 100644 index 0000000..39eef9d --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/simple_germline_variation.yaml @@ -0,0 +1,96 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "simple_germline_variation" +title: Simple Germline Variation +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing simple germline variations called from aligned reads. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: germline_mutation_calling_workflows + backref: simple_germline_variations + label: data_from + target_type: germline_mutation_calling_workflow + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Simple Nucleotide Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - gVCF + - TSV + - VCF + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Simple Germline Variation + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - Genotyping Array + - miRNA-Seq + - RNA-Seq + - Targeted Sequencing + - WGS + - WXS + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Affymetrix SNP 6.0 + - Illumina + + germline_mutation_calling_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/simple_somatic_mutation.yaml b/server/data_files/GDC/model-3.3.0/simple_somatic_mutation.yaml new file mode 100644 index 0000000..88c4faa --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/simple_somatic_mutation.yaml @@ -0,0 +1,105 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "simple_somatic_mutation" +title: Simple Somatic Mutation +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing simple somatic mutations, which have not been annotated or + filtered, called from aligned reads. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: somatic_mutation_calling_workflows + backref: simple_somatic_mutations + label: data_from + target_type: somatic_mutation_calling_workflow + multiplicity: many_to_one + required: false + - name: genomic_profile_harmonization_workflows + backref: simple_somatic_mutations + label: data_from + target_type: genomic_profile_harmonization_workflow + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Combined Nucleotide Variation + - Simple Nucleotide Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - VCF + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Raw CGI Variant + - Raw Simple Somatic Mutation + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - miRNA-Seq + - RNA-Seq + - Targeted Sequencing + - WGS + - WXS + + platform: + $ref: + - "read_group.yaml#/properties/platform" + + somatic_mutation_calling_workflows: + $ref: "_definitions.yaml#/to_one" + + genomic_profile_harmonization_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/slide.yaml b/server/data_files/GDC/model-3.3.0/slide.yaml new file mode 100644 index 0000000..8736797 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/slide.yaml @@ -0,0 +1,216 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "slide" +title: Slide +type: object +namespace: https://gdc.cancer.gov +category: biospecimen +project: '*' +program: '*' +description: >- + A digital image, microscopic or otherwise, of any sample, portion, or sub-part thereof. + (GDC) +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: false + required: true + subgroup: + - name: portions + backref: slides + label: derived_from + target_type: portion + multiplicity: many_to_many + required: false + - name: samples + backref: slides + label: derived_from + target_type: sample + multiplicity: many_to_many + required: false + +required: + - submitter_id + - section_location + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + bone_marrow_malignant_cells: + $ref: + - "_terms.yaml#/bone_marrow_malignant_cells/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + number_proliferating_cells: + $ref: + - "_terms.yaml#/number_proliferating_cells/common" + type: integer + minimum: 0 + + percent_follicular_component: + $ref: + - "_terms.yaml#/percent_follicular_component/common" + type: number + maximum: 100 + minimum: 0 + + percent_rhabdoid_features: + $ref: + - "_terms.yaml#/percent_rhabdoid_features/common" + type: number + maximum: 100 + minimum: 0 + + percent_sarcomatoid_features: + $ref: + - "_terms.yaml#/percent_sarcomatoid_features/common" + type: number + maximum: 100 + minimum: 0 + + percent_tumor_cells: + $ref: + - "_terms.yaml#/percent_tumor_cells/common" + type: number + maximum: 100 + minimum: 0 + + percent_tumor_nuclei: + $ref: + - "_terms.yaml#/percent_tumor_nuclei/common" + type: number + maximum: 100 + minimum: 0 + + percent_normal_cells: + $ref: + - "_terms.yaml#/percent_normal_cells/common" + type: number + maximum: 100 + minimum: 0 + + percent_necrosis: + $ref: + - "_terms.yaml#/percent_necrosis/common" + type: number + maximum: 100 + minimum: 0 + + percent_stromal_cells: + $ref: + - "_terms.yaml#/percent_stromal_cells/common" + type: number + maximum: 100 + minimum: 0 + + percent_inflam_infiltration: + $ref: + - "_terms.yaml#/percent_inflam_infiltration/common" + type: number + maximum: 100 + minimum: 0 + + percent_lymphocyte_infiltration: + $ref: + - "_terms.yaml#/percent_lymphocyte_infiltration/common" + type: number + maximum: 100 + minimum: 0 + + percent_monocyte_infiltration: + $ref: + - "_terms.yaml#/percent_monocyte_infiltration/common" + type: number + maximum: 100 + minimum: 0 + + percent_granulocyte_infiltration: + $ref: + - "_terms.yaml#/percent_granulocyte_infiltration/common" + type: number + maximum: 100 + minimum: 0 + + percent_neutrophil_infiltration: + $ref: + - "_terms.yaml#/percent_neutrophil_infiltration/common" + type: number + maximum: 100 + minimum: 0 + + percent_eosinophil_infiltration: + $ref: + - "_terms.yaml#/percent_eosinophil_infiltration/common" + type: number + maximum: 100 + minimum: 0 + + prostatic_chips_positive_count: + $ref: + - "_terms.yaml#/prostatic_chips_positive_count/common" + type: number + minimum: 0 + + prostatic_chips_total_count: + $ref: + - "_terms.yaml#/prostatic_chips_total_count/common" + type: number + minimum: 0 + + prostatic_involvement_percent: + $ref: + - "_terms.yaml#/prostatic_involvement_percent/common" + type: number + maximum: 100 + minimum: 0 + + section_location: + $ref: + - "_terms.yaml#/section_location/common" + type: string + + tissue_microarray_coordinates: + $ref: + - "_terms.yaml#/tissue_microarray_coordinates/common" + type: string + pattern: "^[a-zA-Z]\\d{1,3}(,[a-zA-Z]\\d{1,3})*$" + + portions: + $ref: "_definitions.yaml#/to_many" + + samples: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/slide_image.yaml b/server/data_files/GDC/model-3.3.0/slide_image.yaml new file mode 100644 index 0000000..a4ccdf1 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/slide_image.yaml @@ -0,0 +1,102 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "slide_image" +title: Slide Image +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing image of a slide. +additionalProperties: false +submittable: true +downloadable: true +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: slides + backref: slide_images + label: data_from + target_type: slide + multiplicity: many_to_many + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Biospecimen + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Cell Culture Image + - Slide Image + - Tissue Microarray Image + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - JPEG + - JPEG 2000 + - SVS + - TIFF + + experimental_strategy: + description: >- + Classification of the image type with respect to its experimental use. + enum: + - Cell Culture + - Diagnostic Slide + - Tissue Slide + + imaging_date: + $ref: + - "_definitions.yaml#/datetime" + + magnification: + description: >- + Magnification used to capture the image. + type: number + + stain_type: + $ref: + - "_terms.yaml#/stain_type/common" + enum: + - Haemotoxylin and Eosin (H&E) + - Immunohistochemistry (IHC) + + slides: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/somatic_aggregation_workflow.yaml b/server/data_files/GDC/model-3.3.0/somatic_aggregation_workflow.yaml new file mode 100644 index 0000000..92d7f08 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/somatic_aggregation_workflow.yaml @@ -0,0 +1,76 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "somatic_aggregation_workflow" +title: Somatic Aggregation Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the somatic mutation aggregation workflow used to generate both the + public and protected MAFs in the GDC DNA-Seq pipelines. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: true + required: true + subgroup: + - name: annotated_somatic_mutations + backref: somatic_aggregation_workflows + label: performed_on + target_type: annotated_somatic_mutation + multiplicity: many_to_many + required: false + - name: simple_somatic_mutations + backref: somatic_aggregation_workflows + label: performed_on + target_type: simple_somatic_mutation + multiplicity: one_to_many + required: false + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - Aliquot Ensemble Somatic Variant Merging and Masking + - CaVEMan Variant Aggregation and Masking + - FoundationOne Variant Aggregation and Masking + - GENIE Variant Aggregation and Masking + - MuSE Variant Aggregation and Masking + - MuTect2 Variant Aggregation and Masking + - Pindel Variant Aggregation and Masking + - SomaticSniper Variant Aggregation and Masking + - Tumor-Only Somatic Variant Merging and Masking + - VarScan2 Variant Aggregation and Masking + + annotated_somatic_mutations: + $ref: "_definitions.yaml#/to_many" + + simple_somatic_mutations: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/somatic_annotation_workflow.yaml b/server/data_files/GDC/model-3.3.0/somatic_annotation_workflow.yaml new file mode 100644 index 0000000..cfa52f5 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/somatic_annotation_workflow.yaml @@ -0,0 +1,66 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "somatic_annotation_workflow" +title: Somatic Annotation Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the somatic mutation annotation pipeline used to annotate the mutations + called in the GDC DNA-Seq pipelines. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: simple_somatic_mutations + backref: somatic_annotation_workflows + label: performed_on + target_type: simple_somatic_mutation + multiplicity: one_to_many + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - CaVEMan Annotation + - FoundationOne Annotation + - GATK4 MuTect2 Annotation + - GATK4 MuTect2 Tumor-Only Annotation + - Manta Indel Annotation + - MuSE Annotation + - MuTect2 Annotation + - Pindel Annotation + - SomaticSniper Annotation + - Strelka2 Annotation + - SvABA Indel Annotation + - VarScan2 Annotation + + simple_somatic_mutations: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/somatic_copy_number_workflow.yaml b/server/data_files/GDC/model-3.3.0/somatic_copy_number_workflow.yaml new file mode 100644 index 0000000..17b0e25 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/somatic_copy_number_workflow.yaml @@ -0,0 +1,73 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "somatic_copy_number_workflow" +title: Somatic Copy Number Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the Somatic Copy Number pipeline used to estimate copy number changes + from different molecular data sources. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - exclusive: true + required: true + subgroup: + - name: submitted_genotyping_arrays + backref: somatic_copy_number_workflows + label: performed_on + target_type: submitted_genotyping_array + multiplicity: many_to_many + required: false + - name: aligned_reads_files + backref: somatic_copy_number_workflows + label: performed_on + target_type: aligned_reads + multiplicity: many_to_many + required: false + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - ABSOLUTE GATK4 CNV Auto + - ABSOLUTE GATK4 CNV Curated + - ABSOLUTE LiftOver + - ASCAT2 + - ASCAT3 + - AscatNGS + - GATK4 CNV + + submitted_genotyping_arrays: + $ref: "_definitions.yaml#/to_many" + + aligned_reads_files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/somatic_mutation_calling_workflow.yaml b/server/data_files/GDC/model-3.3.0/somatic_mutation_calling_workflow.yaml new file mode 100644 index 0000000..d4736a0 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/somatic_mutation_calling_workflow.yaml @@ -0,0 +1,66 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "somatic_mutation_calling_workflow" +title: Somatic Mutation Calling Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the somatic mutation calling pipeline used to call variants in the + GDC DNA-Seq pipelines. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: aligned_reads_files + backref: somatic_mutation_calling_workflows + label: performed_on + target_type: aligned_reads + multiplicity: many_to_many + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - CaVEMan + - GATK4 MuTect2 + - GATK4 MuTect2 Tumor-Only + - Manta Indel + - MuSE + - MuTect2 + - Pindel + - SomaticSniper + - Strelka2 + - Strelka2 RNA + - SvABA Indel + - VarScan2 + + aligned_reads_files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/somatic_mutation_index.yaml b/server/data_files/GDC/model-3.3.0/somatic_mutation_index.yaml new file mode 100644 index 0000000..563a853 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/somatic_mutation_index.yaml @@ -0,0 +1,94 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "somatic_mutation_index" +title: Somatic Mutation Index +type: object +namespace: https://gdc.cancer.gov +category: index_file +project: '*' +program: '*' +description: >- + Data file containing the index for somatic mutation calls. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: simple_somatic_mutations + backref: somatic_mutation_indexes + label: derived_from + target_type: simple_somatic_mutation + multiplicity: one_to_one + required: false + - name: annotated_somatic_mutations + backref: somatic_mutation_indexes + label: derived_from + target_type: annotated_somatic_mutation + multiplicity: one_to_one + required: false + - name: structural_variations + backref: somatic_mutation_indexes + label: derived_from + target_type: structural_variation + multiplicity: one_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Simple Nucleotide Variation + - Somatic Structural Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TBI + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Somatic Mutation Index + + simple_somatic_mutations: + $ref: "_definitions.yaml#/to_one" + + annotated_somatic_mutations: + $ref: "_definitions.yaml#/to_one" + + structural_variations: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/structural_variant_calling_workflow.yaml b/server/data_files/GDC/model-3.3.0/structural_variant_calling_workflow.yaml new file mode 100644 index 0000000..7e50394 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/structural_variant_calling_workflow.yaml @@ -0,0 +1,61 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "structural_variant_calling_workflow" +title: Structural Variant Calling Workflow +type: object +namespace: https://gdc.cancer.gov +category: analysis +project: '*' +program: '*' +description: >- + Metadata for the structural variant calling pipeline used to call structural variants + in the GDC DNA-Seq or RNA-Seq pipelines. +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: aligned_reads_files + backref: structural_variant_calling_workflows + label: performed_on + target_type: aligned_reads + multiplicity: many_to_many + required: true + +required: + - submitter_id + - workflow_link + - workflow_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/workflow_properties" + + workflow_type: + $ref: + - "_terms.yaml#/workflow_type/common" + enum: + - Arriba + - BRASS + - Fusion Catcher + - Manta + - Pizzly + - STAR-Fusion + - SvABA + + aligned_reads_files: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/structural_variation.yaml b/server/data_files/GDC/model-3.3.0/structural_variation.yaml new file mode 100644 index 0000000..63647dc --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/structural_variation.yaml @@ -0,0 +1,111 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "structural_variation" +title: Structural Variation +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing the structural variation data. +additionalProperties: false +submittable: false +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - exclusive: true + required: true + subgroup: + - name: genomic_profile_harmonization_workflows + backref: structural_variations + label: data_from + target_type: genomic_profile_harmonization_workflow + multiplicity: one_to_one + required: false + - name: structural_variant_calling_workflows + backref: structural_variations + label: data_from + target_type: structural_variant_calling_workflow + multiplicity: many_to_one + required: false + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Somatic Structural Variation + - Structural Variation + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - BEDPE + - CSV + - FASTA + - GVF + - JSON + - TSV + - TXT + - VCF + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Structural Alteration + - Structural Rearrangement + - Transcript Fusion + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - RNA-Seq + - Targeted Sequencing + - WGS + - WXS + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Affymetrix SNP 6.0 + - Illumina + - Other + + genomic_profile_harmonization_workflows: + $ref: "_definitions.yaml#/to_one" + + structural_variant_calling_workflows: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/submitted_aligned_reads.yaml b/server/data_files/GDC/model-3.3.0/submitted_aligned_reads.yaml new file mode 100644 index 0000000..54c7852 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/submitted_aligned_reads.yaml @@ -0,0 +1,111 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "submitted_aligned_reads" +title: Submitted Aligned Reads +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing aligned reads that are used as input to GDC workflows. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: read_groups + backref: submitted_aligned_reads_files + label: data_from + target_type: read_group + multiplicity: one_to_many + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - proc_internal + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Sequencing Reads + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Aligned Reads + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - BAM + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - HiChIP + - m6A MeRIP-Seq + - miRNA-Seq + - RNA-Seq + - scATAC-Seq + - scRNA-Seq + - Targeted Sequencing + - WGS + - WXS + deprecated_enum: + - scRNA-Seq + enumDef: + Targeted Sequencing: + $ref: + - "_terms_enum.yaml#/targeted_sequencing/common" + WGS: + $ref: + - "_terms_enum.yaml#/wgs/common" + WXS: + $ref: + - "_terms_enum.yaml#/wxs/common" + + proc_internal: + $ref: + - "_terms.yaml#/proc_internal/common" + enum: + - dna-seq skip + + read_groups: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/submitted_expression_array.yaml b/server/data_files/GDC/model-3.3.0/submitted_expression_array.yaml new file mode 100644 index 0000000..57ff596 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/submitted_expression_array.yaml @@ -0,0 +1,87 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "submitted_expression_array" +title: Submitted Expression Array +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing raw data from an expression array. +additionalProperties: false +submittable: true +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: aliquots + backref: submitted_expression_arrays + label: derived_from + target_type: aliquot + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Transcriptome Profiling + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - CEL + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Raw Intensities + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Expression Array + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - GeneChip U133 Plus 2.0 + - GeneChip U133A + + aliquots: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/submitted_genomic_profile.yaml b/server/data_files/GDC/model-3.3.0/submitted_genomic_profile.yaml new file mode 100644 index 0000000..0ea4a89 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/submitted_genomic_profile.yaml @@ -0,0 +1,97 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "submitted_genomic_profile" +title: Submitted Genomic Profile +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing genomic profile information. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: read_groups + backref: submitted_genomic_profiles + label: data_from + target_type: read_group + multiplicity: many_to_many + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - read_groups + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + type: + enum: + - submitted_genomic_profile + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Combined Nucleotide Variation + - Genomic Profiling + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - FoundationOne Report + - GENIE Report + - Raw CGI Variant + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - MAF + - TSV + - VCF + - XML + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - miRNA-Seq + - RNA-Seq + - Targeted Sequencing + - WGS + - WXS + + read_groups: + $ref: "_definitions.yaml#/to_many" diff --git a/server/data_files/GDC/model-3.3.0/submitted_genotyping_array.yaml b/server/data_files/GDC/model-3.3.0/submitted_genotyping_array.yaml new file mode 100644 index 0000000..071aa71 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/submitted_genotyping_array.yaml @@ -0,0 +1,86 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "submitted_genotyping_array" +title: Submitted Genotyping Array +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing raw data from a genotyping array. +additionalProperties: false +submittable: true +downloadable: true +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: aliquots + backref: submitted_genotyping_arrays + label: derived_from + target_type: aliquot + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - platform + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Copy Number Variation + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Raw Intensities + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - CEL + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Genotyping Array + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Affymetrix SNP 6.0 + + aliquots: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/submitted_methylation_beta_value.yaml b/server/data_files/GDC/model-3.3.0/submitted_methylation_beta_value.yaml new file mode 100644 index 0000000..1ca6be0 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/submitted_methylation_beta_value.yaml @@ -0,0 +1,86 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "submitted_methylation_beta_value" +title: Submitted Methylation Beta Value +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing submitted beta values from a nucleotide methylation array. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: aliquots + backref: submitted_methylation_beta_values + label: derived_from + target_type: aliquot + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - DNA Methylation + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Methylation Beta Value + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TXT + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Methylation Array + + platform: + $ref: + - "_terms.yaml#/platform/common" + enum: + - Illumina Human Methylation 27 + - Illumina Human Methylation 450 + + aliquots: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/submitted_tangent_copy_number.yaml b/server/data_files/GDC/model-3.3.0/submitted_tangent_copy_number.yaml new file mode 100644 index 0000000..7bac979 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/submitted_tangent_copy_number.yaml @@ -0,0 +1,79 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "submitted_tangent_copy_number" +title: Submitted Tangent Copy Number +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing tangent normalized copy number information from an aliquot. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: true +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: aliquots + backref: submitted_tangent_copy_number + label: derived_from + target_type: aliquot + multiplicity: one_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Copy Number Variation + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Copy Number Estimate + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - TXT + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - Genotyping Array + + aliquots: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/submitted_unaligned_reads.yaml b/server/data_files/GDC/model-3.3.0/submitted_unaligned_reads.yaml new file mode 100644 index 0000000..35fcc66 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/submitted_unaligned_reads.yaml @@ -0,0 +1,115 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "submitted_unaligned_reads" +title: Submitted Unaligned Reads +type: object +namespace: https://gdc.cancer.gov +category: data_file +project: '*' +program: '*' +description: >- + Data file containing unaligned reads that have not been GDC Harmonized. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - file_state + - state + - error_type + +links: + - name: read_groups + backref: submitted_unaligned_reads_files + label: data_from + target_type: read_group + multiplicity: many_to_one + required: true + +required: + - submitter_id + - file_name + - file_size + - md5sum + - data_category + - data_format + - data_type + - experimental_strategy + - read_pair_number + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +properties: + + $ref: + - "_definitions.yaml#/data_file_properties" + + data_category: + $ref: + - "_terms.yaml#/data_category/common" + enum: + - Sequencing Reads + + data_type: + $ref: + - "_terms.yaml#/data_type/common" + enum: + - Unaligned Reads + + data_format: + $ref: + - "_terms.yaml#/data_format/common" + enum: + - BAM + - FASTQ + + experimental_strategy: + $ref: + - "_terms.yaml#/experimental_strategy/common" + enum: + - ATAC-Seq + - Bisulfite-Seq + - ChIP-Seq + - HiChIP + - m6A MeRIP-Seq + - miRNA-Seq + - RNA-Seq + - scATAC-Seq + - scRNA-Seq + - Targeted Sequencing + - WGS + - WXS + enumDef: + Targeted Sequencing: + $ref: + - "_terms_enum.yaml#/targeted_sequencing/common" + WGS: + $ref: + - "_terms_enum.yaml#/wgs/common" + WXS: + $ref: + - "_terms_enum.yaml#/wxs/common" + + read_pair_number: + $ref: + - "_terms.yaml#/read_pair_number/common" + enum: + - Not Applicable + - R1 + - R2 + - R3 + enumDef: + Not Applicable: + $ref: + - "_terms_enum.yaml#/not_applicable/common" + + read_groups: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model-3.3.0/tag.yaml b/server/data_files/GDC/model-3.3.0/tag.yaml new file mode 100644 index 0000000..4f4c7e6 --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/tag.yaml @@ -0,0 +1,122 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "tag" +title: Tag +type: object +namespace: https://gdc.cancer.gov +category: TBD +project: '*' +program: '*' +description: >- + Any comment or other information about an entity (deprecated). +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: [] + +required: + - name + +uniqueKeys: + - [id] + - [name] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + + name: + description: >- + name of this tag + enum: + - aliquot + - allcnv + - alleleSpecificCN + - analyte + - auxiliary + - B_Allele_Freq + - batch_effect_removed + - BioSizing + - bisulfite + - byallele + - cgh + - cnv + - control + - cov + - coverage + - cqcf + - Delta_B_Allele_Freq + - DGE + - diagnostic_slides + - drug + - exon + - FIRMA + - follow_up + - gene + - Genotypes + - germline + - harmonized + - hg18 + - hg19 + - hpv + - image + - indel + - ismpolish + - isoform + - junction + - LOH + - lowess_normalized_smoothed + - meth + - miRNA + - MSI + - msi + - nocnv + - Normal_LogR + - normalized + - nte + - omf + - OptionAnalysisPipeline2 + - original + - Paired_LogR + - pairedcn + - patient + - PilotAnalysisPipeline2 + - portion + - protocol + - QA + - qc + - radiation + - raw + - sample + - seg + - segmented + - segmentation + - segnormal + - sif + - slide + - snv + - somatic + - sv + - summary + - Tag + - tangent + - tr + - unnormalized + - Unpaired_LogR + - v1 + - v2 + enumDef: + exon: + $ref: + - "_terms_enum.yaml#/exon/tag/name" diff --git a/server/data_files/GDC/model-3.3.0/tissue_source_site.yaml b/server/data_files/GDC/model-3.3.0/tissue_source_site.yaml new file mode 100644 index 0000000..3e44ecd --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/tissue_source_site.yaml @@ -0,0 +1,57 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "tissue_source_site" +title: Tissue Source Site +type: object +namespace: https://gdc.cancer.gov +category: administrative +project: '*' +program: '*' +description: >- + A clinical site that collects and provides patient samples and clinical metadata + for research use. (NCIt C103264) +additionalProperties: false +submittable: false +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + +links: [] + +uniqueKeys: + - [id] + - [code] + +properties: + + type: + type: string + + id: + $ref: + - "_definitions.yaml#/uuid" + description: >- + UUID for the Tissue Source Site + + name: + description: >- + Name of the source site. + type: string + + code: + description: >- + TCGA-provided TSS code. + type: string + + project: + description: >- + Study name of the project. + type: string + + bcr_id: + description: >- + TCGA-provided BCR id. + type: string diff --git a/server/data_files/GDC/model-3.3.0/treatment.yaml b/server/data_files/GDC/model-3.3.0/treatment.yaml new file mode 100644 index 0000000..322615b --- /dev/null +++ b/server/data_files/GDC/model-3.3.0/treatment.yaml @@ -0,0 +1,7959 @@ +$schema: "http://json-schema.org/draft-04/schema#" + +id: "treatment" +title: Treatment +type: object +namespace: https://gdc.cancer.gov +category: clinical +project: '*' +program: '*' +description: >- + Record of the administration and intention of therapeutic agents provided to a patient + to alter the course of a cancer-related pathologic process. +additionalProperties: false +submittable: true +downloadable: false +previous_version_downloadable: false +validators: null + +systemProperties: + - id + - project_id + - created_datetime + - updated_datetime + - state + +links: + - name: diagnoses + backref: treatments + label: describes + target_type: diagnosis + multiplicity: many_to_one + required: true + +required: + - submitter_id + +uniqueKeys: + - [id] + - [project_id, submitter_id] + +deprecated: + - days_to_treatment + - treatment_anatomic_site + - treatment_arm + - therapeutic_level_achieved + +properties: + + $ref: + - "_definitions.yaml#/ubiquitous_properties" + + chemo_concurrent_to_radiation: + $ref: + - "_terms.yaml#/chemo_concurrent_to_radiation/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + clinical_trial_indicator: + $ref: + - "_terms.yaml#/clinical_trial_indicator/common" + enum: + - "Yes" + - "No" + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + course_number: + $ref: + - "_terms.yaml#/course_number/common" + type: number + + days_to_treatment_end: + $ref: + - "_terms.yaml#/days_to_treatment_end/common" + type: integer + maximum: 32872 + minimum: -32872 + + days_to_treatment_start: + $ref: + - "_terms.yaml#/days_to_treatment_start/common" + type: integer + maximum: 32872 + minimum: -32872 + + drug_category: + $ref: + - "_terms.yaml#/drug_category/common" + enum: + - Glucocorticoid + - Growth factor + - PARP inhibitor + - Platinum + - Unknown + - Not Reported + + embolic_agent: + $ref: + - "_terms.yaml#/embolic_agent/common" + enum: + - Gelfoam + - Lipiodol + - Plastic Beads + - PVA Particles + - Spherical Particles + - Y-90 Sirsphere + - Y-90 Therasphere + - Other + - Unknown + - Not Reported + + initial_disease_status: + $ref: + - "_terms.yaml#/initial_disease_status/common" + enum: + - Initial Diagnosis + - Persistent Disease + - Progressive Disease + - Recurrent Disease + - Refractory Disease + - Residual Disease + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + lesions_treated_number: + $ref: + - "_terms.yaml#/lesions_treated_number/common" + type: number + minimum: 0 + + margin_distance: + $ref: + - "_terms.yaml#/margin_distance/common" + type: number + minimum: 0 + + margin_status: + $ref: + - "_terms.yaml#/margin_status/common" + enum: + - Indeterminate + - Involved + - Uninvolved + - Unknown + - Not Reported + + margins_involved_site: + $ref: + - "_terms.yaml#/margins_involved_site/common" + enum: + - Cervix Uteri + - Gerota Fascia + - Parenchyma + - Perinephric Fat + - Renal + - Renal Capsule + - Renal Sinus + - Renal Vein + - Ureter + - Other + - Unknown + - Not Reported + + number_of_cycles: + $ref: + - "_terms.yaml#/number_of_cycles/common" + type: integer + minimum: 0 + + number_of_fractions: + $ref: + - "_terms.yaml#/number_of_fractions/common" + type: number + minimum: 0 + + prescribed_dose: + $ref: + - "_terms.yaml#/prescribed_dose/common" + type: number + minimum: 0 + + prescribed_dose_units: + $ref: + - "_terms.yaml#/prescribed_dose_units/common" + enum: + - AUC + - cGy + - g/day + - g/m2 + - Gy + - IU/kg + - IU/mg + - mCi + - mEq + - mg + - mg/day + - mg/dL + - mg/kg + - mg/kg/day + - mg/m2 + - mg/m2/day + - mg/m2/wk + - mg/mL + - mg/wk + - mIU + - mL + - ug + - ug/m2 + - Wafer + - Unknown + - Not Reported + + pretreatment: + $ref: + - "_terms.yaml#/pretreatment/common" + enum: + - rhTSH + - Thyroxine Withdrawal + - Unknown + - Not Reported + + protocol_identifier: + $ref: + - "_terms.yaml#/protocol_identifier/common" + enum: + - 321P2 + - 321P3 + - 323P + - "901" + - "911" + - "914" + - "925" + - "935" + - "937" + - "3881" + - "3891" + - "4941" + - "8605" + - "9047" + - "9082" + - "9340" + - "9341" + - "9342" + - "9343" + - "9464" + - "9640" + - "9906" + - A3961 + - A3973 + - A081105 + - A081801 + - AADM01P1 + - AALL03B1 + - AALL07P4 + - AALL08P1 + - AALL0031 + - AALL0232 + - AALL0331 + - AALL0434 + - AALL1131 + - AAML00P2 + - AAML03P1 + - AAML0531 + - AAML0631 + - AAML1031 + - AB9804 + - ACCL05C1 + - ACCL0331 + - ACCL0431 + - ACCL0934 + - ACCL1031 + - ADVL06B1 + - ADVL0018 + - ADVL0212 + - ADVL0214 + - ADVL0215 + - ADVL0421 + - ADVL0524 + - ADVL0525 + - ADVL0714 + - ADVL0812 + - ADVL0813 + - ADVL0821 + - ADVL0911 + - ADVL0912 + - ADVL0918 + - ADVL0921 + - ADVL1011 + - ADVL1111 + - ADVL1112 + - ADVL1115 + - ADVL1213 + - ADVL1412 + - AEPI07N1 + - ALTE03N1 + - ALTE05N1 + - ANBL00B1 + - ANBL00P1 + - ANBL00P3 + - ANBL02P1 + - ANBL09P1 + - ANBL0032 + - ANBL0321 + - ANBL0322 + - ANBL0421 + - ANBL0531 + - ANBL0532 + - ANBL0621 + - ANBL0931 + - ANBL1021 + - ANBL1221 + - ANUR1131 + - AOST06B1 + - AOST06P1 + - AOST0121 + - AOST0331 + - AREN03B2 + - B003 + - B903 + - B947 + - B954 + - B973 + - BCM + - CCG2961 + - D9902 + - E04 + - E18 + - E4512 + - EA5142 + - GBCTTO/99 + - GLATO 2006 + - I03 + - IHRT + - INT-0133 + - N891 + - NWTS-4 + - NWTS-5 + - OSTEO 2006 + - P9407 + - P9462 + - P9641 + - P9754 + - P9851 + - P9906 + - P9963 + - R9702 + - S31 + - S921 + - STB + - Unknown + - Not Reported + + radiosensitizing_agent: + $ref: + - "_terms.yaml#/radiosensitizing_agent/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + reason_treatment_ended: + $ref: + - "_terms.yaml#/reason_treatment_ended/common" + enum: + - Adverse Event + - Course of Therapy Completed + - Death + - Disease Progression + - Withdrawal by Subject + - Other + - Unknown + - Not Reported + enumDef: + Other: + $ref: + - "_terms_enum.yaml#/other/common" + + reason_treatment_not_given: + $ref: + - "_terms.yaml#/reason_treatment_not_given/common" + enum: + - Adverse Event/Complications + - Not Done per Treating Physician's Discretion + - Participant Refusal + - Patient Ineligible + - Scheduling Problems + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + regimen_or_line_of_therapy: + $ref: + - "_terms.yaml#/regimen_or_line_of_therapy/common" + type: string + + residual_disease: + $ref: + - "_terms.yaml#/residual_disease/common" + enum: + - R0 + - R1 + - R2 + - RX + - Unknown + - Not Reported + + route_of_administration: + $ref: + - "_terms.yaml#/route_of_administration/common" + type: array + items: + enum: + - Intrahepatic + - Intramuscular + - Intraperitoneal + - Intrathecal + - Intratumoral + - Intravenous + - Intravesical + - Oral + - Subcutaneous + - Not Reported + + therapeutic_agents: + $ref: + - "_terms.yaml#/therapeutic_agents/common" + enum: + - 2'-F-ara-deoxyuridine + - 2,6-Diaminopurine + - 2,6-Dimethoxyquinone + - 2-Deoxy-D-glucose + - 2-Ethylhydrazide + - 2-Fluoroadenine + - 2-Fluorofucose-containing SGN-2FF + - 2-Hydroxyestradiol + - 2-Hydroxyestrone + - 2-Hydroxyflutamide Depot + - 2-Hydroxyoleic Acid + - 2-Methoxyestradiol + - 2-Methoxyestradiol Nanocrystal Colloidal Dispersion + - 2-Methoxyestrone + - 2-O, 3-O Desulfated Heparin + - 3'-C-ethynylcytidine + - 3'-dA Phosphoramidate NUC-7738 + - 4'-Iodo-4'-Deoxydoxorubicin + - 4-Nitroestrone 3-Methyl Ether + - 4-Thio-2-deoxycytidine + - 5-Aza-4'-thio-2'-deoxycytidine + - 5-Fluoro-2-Deoxycytidine + - 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatases Isoform 3 Inhibitor + ACT-PFK-158 + - 7-Cyanoquinocarcinol + - 7-Ethyl-10-Hydroxycamptothecin + - 7-Hydroxystaurosporine + - 8-Azaguanine + - 9-Ethyl 6-Mercaptopurine + - 9H-Purine-6Thio-98D + - 10-Deacetyltaxol + - 11C Topotecan + - 11D10 AluGel Anti-Idiotype Monoclonal Antibody + - 12-Allyldeoxoartemisinin + - 13-Deoxydoxorubicin + - 14C BMS-275183 + - 17beta-Hydroxysteroid Dehydrogenase Type 5 Inhibitor ASP9521 + - A2A Receptor Antagonist EOS100850 + - Abagovomab + - Abarelix + - Abemaciclib + - Abemaciclib Mesylate + - Abexinostat + - Abexinostat Tosylate + - Abiraterone + - Abiraterone Acetate + - Abituzumab + - Acai Berry Juice + - Acalabrutinib + - Acalisib + - Aceglatone + - Acetylcysteine + - Acitretin + - Acivicin + - Aclacinomycin B + - Aclarubicin + - Acodazole + - Acodazole Hydrochloride + - Acolbifene Hydrochloride + - Acridine + - Acridine Carboxamide + - Acronine + - Actinium Ac 225 Lintuzumab + - Actinium Ac 225-FPI-1434 + - Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591 + - Actinomycin C2 + - Actinomycin C3 + - Actinomycin F1 + - Activin Type 2B Receptor Fc Fusion Protein STM 434 + - Acyclic Nucleoside Phosphonate Prodrug ABI-1968 + - Ad-RTS-hIL-12 + - Adagloxad Simolenin + - Adavosertib + - Adecatumumab + - Adenosine A2A Receptor Antagonist AZD4635 + - Adenosine A2A Receptor Antagonist CS3005 + - Adenosine A2A Receptor Antagonist NIR178 + - Adenosine A2A Receptor Antagonist/Phosphodiesterase 10A PBF-999 + - Adenosine A2A/A2B Receptor Antagonist AB928 + - Adenosine A2B Receptor Antagonist PBF-1129 + - Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific + Prostate Cancer Vaccine BPX-201 + - Adenoviral Brachyury Vaccine ETBX-051 + - Adenoviral Cancer Vaccine PF-06936308 + - Adenoviral MUC1 Vaccine ETBX-061 + - Adenoviral PSA Vaccine ETBX-071 + - Adenoviral Transduced hIL-12-expressing Autologous Dendritic Cells INXN-3001 + Plus Activator Ligand INXN-1001 + - Adenoviral Tumor-specific Neoantigen Priming Vaccine GAd-209-FSP + - Adenoviral Tumor-specific Neoantigen Priming Vaccine GRT-C901 + - Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE + - Adenovirus Serotype 26-expressing HPV16 Vaccine JNJ-63682918 + - Adenovirus Serotype 26-expressing HPV18 Vaccine JNJ-63682931 + - Adenovirus-expressing TLR5/TLR5 Agonist Nanoformulation M-VM3 + - Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001 + - Aderbasib + - ADH-1 + - AE37 Peptide/GM-CSF Vaccine + - AEE788 + - Aerosol Gemcitabine + - Aerosolized Aldesleukin + - Aerosolized Liposomal Rubitecan + - Afatinib + - Afatinib Dimaleate + - Afimoxifene + - Afuresertib + - Agatolimod Sodium + - Agerafenib + - Aglatimagene Besadenovec + - Agonistic Anti-CD40 Monoclonal Antibody ADC-1013 + - Agonistic Anti-OX40 Monoclonal Antibody INCAGN01949 + - Agonistic Anti-OX40 Monoclonal Antibody MEDI6469 + - AKR1C3-activated Prodrug OBI-3424 + - AKT 1/2 Inhibitor BAY1125976 + - AKT Inhibitor ARQ 092 + - Akt Inhibitor LY2780301 + - Akt Inhibitor MK2206 + - Akt Inhibitor SR13668 + - Akt/ERK Inhibitor ONC201 + - Alacizumab Pegol + - Alanosine + - Albumin-binding Cisplatin Prodrug BTP-114 + - Aldesleukin + - Aldoxorubicin + - Alectinib + - Alefacept + - Alemtuzumab + - Alestramustine + - Alflutinib Mesylate + - Algenpantucel-L + - Alisertib + - Alitretinoin + - ALK Inhibitor + - ALK Inhibitor ASP3026 + - ALK Inhibitor PLB 1003 + - ALK Inhibitor RO5424802 + - ALK Inhibitor TAE684 + - ALK Inhibitor WX-0593 + - ALK-2 Inhibitor TP-0184 + - ALK-FAK Inhibitor CEP-37440 + - ALK/c-Met Inhibitor TQ-B3139 + - ALK/FAK/Pyk2 Inhibitor CT-707 + - ALK/ROS1/Met Inhibitor TQ-B3101 + - ALK/TRK Inhibitor TSR-011 + - Alkotinib + - Allodepleted T Cell Immunotherapeutic ATIR101 + - Allogeneic Anti-BCMA CAR-transduced T-cells ALLO-715 + - Allogeneic Anti-BCMA-CAR T-cells PBCAR269A + - Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells + - Allogeneic Anti-CD19 CAR T-cells ALLO-501A + - Allogeneic Anti-CD19 Universal CAR-T Cells CTA101 + - Allogeneic Anti-CD19-CAR T-cells PBCAR0191 + - Allogeneic Anti-CD20 CAR T-cells LUCAR-20S + - Allogeneic Anti-CD20-CAR T-cells PBCAR20A + - Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100 + - Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001 + - Allogeneic CD22-specific Universal CAR-expressing T-lymphocytes UCART22 + - Allogeneic CD56-positive CD3-negative Natural Killer Cells CYNK-001 + - Allogeneic Cellular Vaccine 1650-G + - Allogeneic CRISPR-Cas9 Engineered Anti-BCMA T Cells CTX120 + - Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130 + - Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A + - Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM + - Allogeneic GM-CSF-secreting Lethally Irradiated Prostate Cancer Vaccine + - Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine + - Allogeneic GM-CSF-secreting Tumor Vaccine PANC 6.03 pcDNA-1/GM-Neo + - Allogeneic GM-CSF-secreting Tumor Vaccine PANC 10.05 pcDNA-1/GM-Neo + - Allogeneic IL13-Zetakine/HyTK-Expressing-Glucocorticoid Resistant Cytotoxic + T Lymphocytes GRm13Z40-2 + - Allogeneic Irradiated Melanoma Cell Vaccine CSF470 + - Allogeneic Large Multivalent Immunogen Melanoma Vaccine LP2307 + - Allogeneic Melanoma Vaccine AGI-101H + - Allogeneic Natural Killer Cell Line MG4101 + - Allogeneic Natural Killer Cell Line NK-92 + - Allogeneic Plasmacytoid Dendritic Cells Expressing Lung Tumor Antigens PDC*lung01 + - Allogeneic Renal Cell Carcinoma Vaccine MGN1601 + - Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T-cells + CTL 19 + - Allosteric ErbB Inhibitor BDTX-189 + - Allovectin-7 + - Almurtide + - Alobresib + - Alofanib + - Alpelisib + - Alpha Galactosylceramide + - Alpha V Beta 1 Inhibitor ATN-161 + - Alpha V Beta 8 Antagonist PF-06940434 + - alpha-Folate Receptor-targeting Thymidylate Synthase Inhibitor ONX-0801 + - Alpha-Gal AGI-134 + - Alpha-lactalbumin-derived Synthetic Peptide-lipid Complex Alpha1H + - Alpha-Thioguanine Deoxyriboside + - Alpha-tocopheryloxyacetic Acid + - Alsevalimab + - Altiratinib + - Altretamine + - Alvespimycin + - Alvespimycin Hydrochloride + - Alvocidib + - Alvocidib Hydrochloride + - Alvocidib Prodrug TP-1287 + - Amatuximab + - Ambamustine + - Ambazone + - Amblyomin-X + - Amcasertib + - Ametantrone + - Amifostine + - Amino Acid Injection + - Aminocamptothecin + - Aminocamptothecin Colloidal Dispersion + - Aminoflavone Prodrug AFP464 + - Aminopterin + - Aminopterin Sodium + - Amivantamab + - Amolimogene Bepiplasmid + - Amonafide L-Malate + - Amrubicin + - Amrubicin Hydrochloride + - Amsacrine + - Amsacrine Lactate + - Amsilarotene + - Amustaline + - Amustaline Dihydrochloride + - Amuvatinib + - Amuvatinib Hydrochloride + - Anakinra + - Anastrozole + - Anaxirone + - Ancitabine + - Ancitabine Hydrochloride + - Andecaliximab + - Androgen Antagonist APC-100 + - Androgen Receptor Antagonist BAY 1161116 + - Androgen Receptor Antagonist SHR3680 + - Androgen Receptor Antagonist TAS3681 + - Androgen Receptor Antagonist TRC253 + - Androgen Receptor Antisense Oligonucleotide AZD5312 + - Androgen Receptor Antisense Oligonucleotide EZN-4176 + - Androgen Receptor Degrader ARV-110 + - Androgen Receptor Degrader CC-94676 + - Androgen Receptor Downregulator AZD3514 + - Androgen Receptor Inhibitor EPI-7386 + - Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118 + - Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10 + - Andrographolide + - Androstane Steroid HE3235 + - Anetumab Ravtansine + - Ang2/VEGF-Binding Peptides-Antibody Fusion Protein CVX-241 + - Angiogenesis Inhibitor GT-111 + - Angiogenesis Inhibitor JI-101 + - Angiogenesis/Heparanase Inhibitor PG545 + - Angiopoietin-2-specific Fusion Protein PF-04856884 + - Anhydrous Enol-oxaloacetate + - Anhydrovinblastine + - Aniline Mustard + - Anlotinib Hydrochloride + - Annamycin + - Annamycin Liposomal + - Annonaceous Acetogenins + - Ansamitomicin P-3 + - Anthramycin + - Anthrapyrazole + - Anti c-KIT Antibody-drug Conjugate LOP628 + - Anti-5T4 Antibody-drug Conjugate ASN004 + - Anti-5T4 Antibody-Drug Conjugate PF-06263507 + - Anti-5T4 Antibody-drug Conjugate SYD1875 + - Anti-A5B1 Integrin Monoclonal Antibody PF-04605412 + - Anti-A33 Monoclonal Antibody KRN330 + - Anti-ACTR/4-1BB/CD3zeta-Viral Vector-transduced Autologous T-Lymphocytes ACTR087 + - Anti-AG7 Antibody Drug Conjugate AbGn-107 + - Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME + - Anti-AGS-8 Monoclonal Antibody AGS-8M4 + - Anti-AGS-16 Monoclonal Antibody AGS-16M18 + - Anti-alpha5beta1 Integrin Antibody MINT1526A + - Anti-alpha BCMA/Anti-alpha CD3 T-cell Engaging Bispecific Antibody TNB-383B + - Anti-ANG2 Monoclonal Antibody MEDI-3617 + - Anti-angiopoietin Monoclonal Antibody AMG 780 + - Anti-APRIL Monoclonal Antibody BION-1301 + - Anti-AXL Fusion Protein AVB-S6-500 + - Anti-AXL/PBD Antibody-drug Conjugate ADCT-601 + - Anti-B7-H3 Antibody DS-5573a + - Anti-B7-H3/DXd Antibody-drug Conjugate DS-7300a + - Anti-B7-H4 Monoclonal Antibody FPA150 + - Anti-B7H3 Antibody-drug Conjugate MGC018 + - Anti-BCMA Antibody SEA-BCMA + - Anti-BCMA Antibody-drug Conjugate AMG 224 + - Anti-BCMA Antibody-drug Conjugate CC-99712 + - Anti-BCMA Antibody-drug Conjugate GSK2857916 + - Anti-BCMA SparX Protein Plus BCMA-directed Anti-TAAG ARC T-cells CART-ddBCMA + - Anti-BCMA/Anti-CD3 Bispecific Antibody REGN5459 + - Anti-BCMA/CD3 BiTE Antibody AMG 420 + - Anti-BCMA/CD3 BiTE Antibody AMG 701 + - Anti-BCMA/CD3 BiTE Antibody REGN5458 + - Anti-BCMA/PBD ADC MEDI2228 + - Anti-BTLA Monoclonal Antibody TAB004 + - Anti-BTN3A Agonistic Monoclonal Antibody ICT01 + - Anti-C4.4a Antibody-Drug Conjugate BAY1129980 + - Anti-C5aR Monoclonal Antibody IPH5401 + - Anti-c-fms Monoclonal Antibody AMG 820 + - Anti-c-KIT Monoclonal Antibody CDX 0158 + - Anti-c-Met Antibody-drug Conjugate HTI-1066 + - Anti-c-Met Antibody-drug Conjugate TR1801 + - Anti-c-Met Monoclonal Antibody ABT-700 + - Anti-c-Met Monoclonal Antibody ARGX-111 + - Anti-c-Met Monoclonal Antibody HLX55 + - Anti-c-MET Monoclonal Antibody LY2875358 + - Anti-C-met Monoclonal Antibody SAIT301 + - Anti-CA6-DM4 Immunoconjugate SAR566658 + - Anti-CA19-9 Monoclonal Antibody 5B1 + - Anti-CCR7 Antibody-drug Conjugate JBH492 + - Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1) + - Anti-CD3/Anti-5T4 Bispecific Antibody GEN1044 + - Anti-CD3/Anti-BCMA Bispecific Monoclonal Antibody JNJ-64007957 + - Anti-CD3/Anti-BCMA Bispecific Monoclonal Antibody PF-06863135 + - Anti-CD3/Anti-CD20 Trifunctional Bispecific Monoclonal Antibody FBTA05 + - Anti-CD3/Anti-GPRC5D Bispecific Monoclonal Antibody JNJ-64407564 + - Anti-CD3/Anti-GUCY2C Bispecific Antibody PF-07062119 + - Anti-CD3/CD7-Ricin Toxin A Immunotoxin + - Anti-CD3/CD20 Bispecific Antibody GEN3013 + - Anti-CD3/CD38 Bispecific Monoclonal Antibody AMG 424 + - Anti-CD19 Antibody-drug Conjugate SGN-CD19B + - Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003 + - Anti-CD19 iCAR NK Cells + - Anti-CD19 Monoclonal Antibody DI-B4 + - Anti-CD19 Monoclonal Antibody MDX-1342 + - Anti-CD19 Monoclonal Antibody MEDI-551 + - Anti-CD19 Monoclonal Antibody XmAb5574 + - Anti-CD19-DM4 Immunoconjugate SAR3419 + - Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL + - Anti-CD19/CD3 BiTE Antibody AMG 562 + - Anti-CD19/CD3 Tetravalent Antibody AFM11 + - Anti-CD19/CD22 CAR NK Cells + - Anti-CD20 Monoclonal Antibody B001 + - Anti-CD20 Monoclonal Antibody BAT4306F + - Anti-CD20 Monoclonal Antibody MIL62 + - Anti-CD20 Monoclonal Antibody PRO131921 + - Anti-CD20 Monoclonal Antibody SCT400 + - Anti-CD20 Monoclonal Antibody TL011 + - Anti-CD20 Monoclonal Antibody-Interferon-alpha Fusion Protein IGN002 + - Anti-CD20-engineered Toxin Body MT-3724 + - Anti-CD20/Anti-CD3 Bispecific IgM Antibody IGM2323 + - Anti-CD20/CD3 Monoclonal Antibody REGN1979 + - Anti-CD20/CD3 Monoclonal Antibody XmAb13676 + - Anti-CD22 ADC TRPH-222 + - Anti-CD22 Monoclonal Antibody-MMAE Conjugate DCDT2980S + - Anti-CD25 Monoclonal Antibody RO7296682 + - Anti-CD25-PBD Antibody-drug Conjugate ADCT-301 + - Anti-CD26 Monoclonal Antibody YS110 + - Anti-CD27 Agonistic Monoclonal Antibody MK-5890 + - Anti-CD27L Antibody-Drug Conjugate AMG 172 + - Anti-CD30 Monoclonal Antibody MDX-1401 + - Anti-CD30 Monoclonal Antibody XmAb2513 + - Anti-CD30/CD16A Monoclonal Antibody AFM13 + - Anti-CD30/DM1 Antibody-drug Conjugate F0002 + - Anti-CD32B Monoclonal Antibody BI-1206 + - Anti-CD33 Antibody-drug Conjugate IMGN779 + - Anti-CD33 Antigen/CD3 Receptor Bispecific Monoclonal Antibody AMV564 + - Anti-CD33 Monoclonal Antibody BI 836858 + - Anti-CD33 Monoclonal Antibody-DM4 Conjugate AVE9633 + - Anti-CD33/CD3 Bispecific Antibody GEM 333 + - Anti-CD33/CD3 Bispecific Antibody JNJ-67571244 + - Anti-CD33/CD3 BiTE Antibody AMG 330 + - Anti-CD33/CD3 BiTE Antibody AMG 673 + - Anti-CD37 Antibody-Drug Conjugate IMGN529 + - Anti-CD37 Bispecific Monoclonal Antibody GEN3009 + - Anti-CD37 MMAE Antibody-drug Conjugate AGS67E + - Anti-CD37 Monoclonal Antibody BI 836826 + - Anti-CD38 Antibody-drug Conjugate STI-6129 + - Anti-CD38 Monoclonal Antibody MOR03087 + - Anti-CD38 Monoclonal Antibody SAR442085 + - Anti-CD38 Monoclonal Antibody TAK-079 + - Anti-CD38-targeted IgG4-attenuated IFNa TAK-573 + - Anti-CD38/CD3 Bispecific Monoclonal Antibody GBR 1342 + - Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257 + - Anti-CD39 Monoclonal Antibody SRF617 + - Anti-CD39 Monoclonal Antibody TTX-030 + - Anti-CD40 Agonist Monoclonal Antibody ABBV-927 + - Anti-CD40 Agonist Monoclonal Antibody CDX-1140 + - Anti-CD40 Monoclonal Antibody Chi Lob 7/4 + - Anti-CD40 Monoclonal Antibody SEA-CD40 + - Anti-CD40/Anti-4-1BB Bispecific Agonist Monoclonal Antibody GEN1042 + - Anti-CD40/Anti-TAA Bispecific Monoclonal Antibody ABBV-428 + - Anti-CD40L Fc-Fusion Protein BMS-986004 + - Anti-CD44 Monoclonal Antibody RO5429083 + - Anti-CD45 Monoclonal Antibody AHN-12 + - Anti-CD46 Antibody-drug Conjugate FOR46 + - Anti-CD47 ADC SGN-CD47M + - Anti-CD47 Monoclonal Antibody AO-176 + - Anti-CD47 Monoclonal Antibody CC-90002 + - Anti-CD47 Monoclonal Antibody Hu5F9-G4 + - Anti-CD47 Monoclonal Antibody IBI188 + - Anti-CD47 Monoclonal Antibody IMC-002 + - Anti-CD47 Monoclonal Antibody SHR-1603 + - Anti-CD47 Monoclonal Antibody SRF231 + - Anti-CD47 Monoclonal Antibody TJC4 + - Anti-CD47/CD19 Bispecific Monoclonal Antibody TG-1801 + - Anti-CD48/MMAE Antibody-drug Conjugate SGN-CD48A + - Anti-CD52 Monoclonal Antibody ALLO-647 + - Anti-CD70 Antibody-Drug Conjugate MDX-1203 + - Anti-CD70 Antibody-drug Conjugate SGN-CD70A + - Anti-CD70 CAR-expressing T Lymphocytes + - Anti-CD70 Monoclonal Antibody MDX-1411 + - Anti-CD71/vcMMAE Probody-drug Conjugate CX-2029 + - Anti-CD73 Monoclonal Antibody BMS-986179 + - Anti-CD73 Monoclonal Antibody CPI-006 + - Anti-CD73 Monoclonal Antibody NZV930 + - Anti-CD73 Monoclonal Antibody TJ4309 + - Anti-CD74 Antibody-drug Conjugate STRO-001 + - Anti-CD98 Monoclonal Antibody IGN523 + - Anti-CD117 Monoclonal Antibody JSP191 + - Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1 + - Anti-CD123 ADC IMGN632 + - Anti-CD123 Monoclonal Antibody CSL360 + - Anti-CD123 Monoclonal Antibody KHK2823 + - Anti-CD123 x Anti-CD3 Bispecific Antibody XmAb1404 + - Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A + - Anti-CD123/CD3 Bispecific Antibody APVO436 + - Anti-CD123/CD3 Bispecific Antibody JNJ-63709178 + - Anti-CD123/CD3 BiTE Antibody SAR440234 + - Anti-CD137 Agonistic Monoclonal Antibody ADG106 + - Anti-CD137 Agonistic Monoclonal Antibody AGEN2373 + - Anti-CD137 Agonistic Monoclonal Antibody ATOR-1017 + - Anti-CD137 Agonistic Monoclonal Antibody CTX-471 + - Anti-CD137 Agonistic Monoclonal Antibody LVGN6051 + - Anti-CD157 Monoclonal Antibody MEN1112 + - Anti-CD166 Probody-drug Conjugate CX-2009 + - Anti-CD205 Antibody-drug Conjugate OBT076 + - Anti-CD228/MMAE Antibody-drug Conjugate SGN-CD228A + - Anti-CD352 Antibody-drug Conjugate SGN-CD352A + - Anti-CDH6 Antibody-drug Conjugate HKT288 + - Anti-CEA BiTE Monoclonal Antibody AMG211 + - Anti-CEA/Anti-DTPA-In (F6-734) Bispecific Antibody + - Anti-CEA/Anti-HSG Bispecific Monoclonal Antibody TF2 + - Anti-CEACAM1 Monoclonal Antibody CM-24 + - Anti-CEACAM5 Antibody-Drug Conjugate SAR408701 + - Anti-CEACAM6 AFAIKL2 Antibody Fragment/Jack Bean Urease Immunoconjugate L-DOS47 + - Anti-CEACAM6 Antibody BAY1834942 + - Anti-claudin18.2 Monoclonal Antibody AB011 + - Anti-Claudin18.2 Monoclonal Antibody TST001 + - Anti-CLDN6 Monoclonal Antibody ASP1650 + - Anti-CLEC12A/CD3 Bispecific Antibody MCLA117 + - Anti-CLEVER-1 Monoclonal Antibody FP-1305 + - Anti-CSF1 Monoclonal Antibody PD-0360324 + - Anti-CSF1R Monoclonal Antibody IMC-CS4 + - Anti-CSF1R Monoclonal Antibody SNDX-6352 + - Anti-CTGF Monoclonal Antibody FG-3019 + - Anti-CTLA4 Antibody Fc Fusion Protein KN044 + - Anti-CTLA4 Monoclonal Antibody BMS-986218 + - Anti-CTLA-4 Monoclonal Antibody ADG116 + - Anti-CTLA-4 Monoclonal Antibody ADU-1604 + - Anti-CTLA-4 Monoclonal Antibody AGEN1181 + - Anti-CTLA-4 Monoclonal Antibody BCD-145 + - Anti-CTLA-4 Monoclonal Antibody HBM4003 + - Anti-CTLA-4 Monoclonal Antibody MK-1308 + - Anti-CTLA-4 Monoclonal Antibody ONC-392 + - Anti-CTLA-4 Monoclonal Antibody REGN4659 + - Anti-CTLA-4 Probody BMS-986288 + - Anti-CTLA-4/Anti-PD-1 Monoclonal Antibody Combination BCD-217 + - Anti-CTLA-4/LAG-3 Bispecific Antibody XmAb22841 + - Anti-CTLA-4/OX40 Bispecific Antibody ATOR-1015 + - Anti-CXCR4 Monoclonal Antibody PF-06747143 + - Anti-Denatured Collagen Monoclonal Antibody TRC093 + - Anti-DKK1 Monoclonal Antibody BHQ880 + - Anti-DKK-1 Monoclonal Antibody LY2812176 + - Anti-DLL3/CD3 BiTE Antibody AMG 757 + - Anti-DLL4 Monoclonal Antibody MEDI0639 + - Anti-DLL4/VEGF Bispecific Monoclonal Antibody OMP-305B83 + - Anti-DR5 Agonist Monoclonal Antibody TRA-8 + - Anti-DR5 Agonistic Antibody DS-8273a + - Anti-DR5 Agonistic Monoclonal Antibody INBRX-109 + - Anti-EGFR Monoclonal Antibody CPGJ 602 + - Anti-EGFR Monoclonal Antibody EMD 55900 + - Anti-EGFR Monoclonal Antibody GC1118 + - Anti-EGFR Monoclonal Antibody GT-MAB 5.2-GEX + - Anti-EGFR Monoclonal Antibody HLX-07 + - Anti-EGFR Monoclonal Antibody Mixture MM-151 + - Anti-EGFR Monoclonal Antibody RO5083945 + - Anti-EGFR Monoclonal Antibody SCT200 + - Anti-EGFR Monoclonal Antibody SYN004 + - Anti-EGFR TAP Antibody-drug Conjugate IMGN289 + - Anti-EGFR/c-Met Bispecific Antibody EMB-01 + - Anti-EGFR/c-Met Bispecific Antibody JNJ-61186372 + - Anti-EGFR/CD16A Bispecific Antibody AFM24 + - Anti-EGFR/DM1 Antibody-drug Conjugate AVID100 + - Anti-EGFR/HER2/HER3 Monoclonal Antibody Mixture Sym013 + - Anti-EGFR/PBD Antibody-drug Conjugate ABBV-321 + - Anti-EGFRvIII Antibody Drug Conjugate AMG 595 + - Anti-EGFRvIII Immunotoxin MR1-1 + - Anti-EGFRvIII/CD3 BiTE Antibody AMG 596 + - Anti-EGP-2 Immunotoxin MOC31-PE + - Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F + - Anti-ENPP3/MMAF Antibody-Drug Conjugate AGS-16M8F + - Anti-Ep-CAM Monoclonal Antibody ING-1 + - Anti-EphA2 Antibody-directed Liposomal Docetaxel Prodrug MM-310 + - Anti-EphA2 Monoclonal Antibody DS-8895a + - Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547 + - Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111 + - Anti-ErbB3 Antibody ISU104 + - Anti-ErbB3 Monoclonal Antibody AV-203 + - Anti-ErbB3 Monoclonal Antibody CDX-3379 + - Anti-ErbB3 Monoclonal Antibody REGN1400 + - Anti-ErbB3/Anti-IGF-1R Bispecific Monoclonal Antibody MM-141 + - Anti-ETBR/MMAE Antibody-Drug Conjugate DEDN6526A + - Anti-FAP/Interleukin-2 Fusion Protein RO6874281 + - Anti-FCRH5/CD3 BiTE Antibody BFCR4350A + - Anti-FGFR2 Antibody BAY1179470 + - Anti-FGFR3 Antibody-drug Conjugate LY3076226 + - Anti-FGFR4 Monoclonal Antibody U3-1784 + - Anti-FLT3 Antibody-drug Conjugate AGS62P1 + - Anti-FLT3 Monoclonal Antibody 4G8-SDIEM + - Anti-FLT3 Monoclonal Antibody IMC-EB10 + - Anti-FLT3/CD3 BiTE Antibody AMG 427 + - Anti-Folate Receptor-alpha Antibody Drug Conjugate STRO-002 + - Anti-FRA/Eribulin Antibody-drug Conjugate MORAb-202 + - Anti-fucosyl-GM1 Monoclonal Antibody BMS-986012 + - Anti-Ganglioside GM2 Monoclonal Antibody BIW-8962 + - Anti-GARP Monoclonal Antibody ABBV-151 + - Anti-GCC Antibody-Drug Conjugate MLN0264 + - Anti-GCC Antibody-Drug Conjugate TAK-164 + - Anti-GD2 hu3F8/Anti-CD3 huOKT3 Bispecific Antibody + - Anti-GD2 Monoclonal Antibody hu14.18K322A + - Anti-GD2 Monoclonal Antibody MORAb-028 + - Anti-GD3 Antibody-drug Conjugate PF-06688992 + - Anti-GITR Agonistic Monoclonal Antibody ASP1951 + - Anti-GITR Agonistic Monoclonal Antibody BMS-986156 + - Anti-GITR Agonistic Monoclonal Antibody INCAGN01876 + - Anti-GITR Monoclonal Antibody GWN 323 + - Anti-GITR Monoclonal Antibody MK-4166 + - Anti-Globo H Monoclonal Antibody OBI-888 + - Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999 + - Anti-Glypican 3/CD3 Bispecific Antibody ERY974 + - Anti-GnRH Vaccine PEP223 + - Anti-gpA33/CD3 Monoclonal Antibody MGD007 + - Anti-GPR20/DXd Antibody-drug Conjugate DS-6157a + - Anti-gremlin-1 Monoclonal Antibody UCB6114 + - Anti-GRP78 Monoclonal Antibody PAT-SM6 + - Anti-HA Epitope Monoclonal Antibody MEDI8852 + - Anti-HB-EGF Monoclonal Antibody KHK2866 + - Anti-HBEGF Monoclonal Antibody U3-1565 + - Anti-hepcidin Monoclonal Antibody LY2787106 + - Anti-HER2 ADC DS-8201a + - Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702 + - Anti-HER2 Antibody-drug Conjugate A166 + - Anti-HER2 Antibody-drug Conjugate ARX788 + - Anti-HER2 Antibody-drug Conjugate BAT8001 + - Anti-HER2 Antibody-drug Conjugate DP303c + - Anti-HER2 Antibody-drug Conjugate MEDI4276 + - Anti-HER2 Antibody-drug Conjugate RC48 + - Anti-HER2 Bi-specific Monoclonal Antibody ZW25 + - Anti-HER2 Bispecific Antibody-drug Conjugate ZW49 + - Anti-HER2 Immune Stimulator-antibody Conjugate NJH395 + - Anti-HER2 Monoclonal Antibody B002 + - Anti-HER2 Monoclonal Antibody CT-P6 + - Anti-HER2 Monoclonal Antibody HLX22 + - Anti-HER2 Monoclonal Antibody/Anti-CD137Anticalin Bispecific Fusion Protein + PRS-343 + - Anti-HER2-DM1 ADC B003 + - Anti-HER2-DM1 Antibody-drug Conjugate GQ1001 + - Anti-HER2-vc0101 ADC PF-06804103 + - Anti-HER2/Anti-CD3 Bispecific Monoclonal Antibody BTRC 4017A + - Anti-HER2/Anti-CD3 Bispecific Monoclonal Antibody GBR 1302 + - Anti-HER2/Anti-HER3 Bispecific Monoclonal Antibody MCLA-128 + - Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522 + - Anti-HER2/MMAE Antibody-drug Conjugate MRG002 + - Anti-HER2/PBD-MA Antibody-drug Conjugate DHES0815A + - Anti-HER3 Antibody-drug Conjugate U3 1402 + - Anti-HER3 Monoclonal Antibody GSK2849330 + - Anti-HER-2 Bispecific Antibody KN026 + - Anti-HGF Monoclonal Antibody TAK-701 + - Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968 + - Anti-HIV-1 Lentiviral Vector-expressing sh5/C46 Cal-1 + - Anti-HLA-DR Monoclonal Antibody IMMU-114 + - Anti-HLA-G Antibody TTX-080 + - Anti-human GITR Monoclonal Antibody AMG 228 + - Anti-human GITR Monoclonal Antibody TRX518 + - Anti-ICAM-1 Monoclonal Antibody BI-505 + - Anti-ICOS Agonist Antibody GSK3359609 + - Anti-ICOS Agonist Monoclonal Antibody BMS-986226 + - Anti-ICOS Monoclonal Antibody KY1044 + - Anti-ICOS Monoclonal Antibody MEDI-570 + - Anti-IGF-1R Monoclonal Antibody AVE1642 + - Anti-IGF-1R Recombinant Monoclonal Antibody BIIB022 + - Anti-IL-1 alpha Monoclonal Antibody MABp1 + - Anti-IL-8 Monoclonal Antibody BMS-986253 + - Anti-IL-8 Monoclonal Antibody HuMax-IL8 + - Anti-IL-13 Humanized Monoclonal Antibody TNX-650 + - Anti-IL-15 Monoclonal Antibody AMG 714 + - Anti-ILDR2 Monoclonal Antibody BAY 1905254 + - Anti-ILT4 Monoclonal Antibody MK-4830 + - Anti-integrin Beta-6/MMAE Antibody-drug Conjugate SGN-B6A + - Anti-Integrin Monoclonal Antibody-DM4 Immunoconjugate IMGN388 + - Anti-IRF4 Antisense Oligonucleotide ION251 + - Anti-KIR Monoclonal Antibody IPH 2101 + - Anti-KSP/Anti-VEGF siRNAs ALN-VSP02 + - Anti-LAG3 Monoclonal Antibody BI 754111 + - Anti-LAG3 Monoclonal Antibody MK-4280 + - Anti-LAG3 Monoclonal Antibody TSR-033 + - Anti-LAG-3 Monoclonal Antibody IBI-110 + - Anti-LAG-3 Monoclonal Antibody INCAGN02385 + - Anti-LAG-3 Monoclonal Antibody LAG525 + - Anti-LAG-3 Monoclonal Antibody REGN3767 + - Anti-LAG-3/PD-L1 Bispecific Antibody FS118 + - Anti-LAMP1 Antibody-drug Conjugate SAR428926 + - Anti-latent TGF-beta 1 Monoclonal Antibody SRK-181 + - Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102 + - Anti-LGR5 Monoclonal Antibody BNC101 + - Anti-LIF Monoclonal Antibody MSC-1 + - Anti-LILRB4 Monoclonal Antibody IO-202 + - Anti-LIV-1 Monoclonal Antibody-MMAE Conjugate SGN-LIV1A + - Anti-Ly6E Antibody-Drug Conjugate RG 7841 + - Anti-MAGE-A4 T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-C103C + - Anti-Melanin Monoclonal Antibody PTI-6D2 + - Anti-mesothelin Antibody-drug Conjugate BMS-986148 + - Anti-mesothelin-Pseudomonas Exotoxin 24 Cytolytic Fusion Protein LMB-100 + - Anti-mesothelin/MMAE Antibody-Drug Conjugate DMOT4039A + - Anti-mesothelin/MMAE Antibody-drug Conjugate RC88 + - Anti-Met Monoclonal Antibody Mixture Sym015 + - Anti-Met/EGFR Monoclonal Antibody LY3164530 + - Anti-MMP-9 Monoclonal Antibody GS-5745 + - Anti-MUC1 Monoclonal Antibody BTH1704 + - Anti-MUC16/CD3 Bispecific Antibody REGN4018 + - Anti-MUC16/CD3 BiTE Antibody REGN4018 + - Anti-MUC16/MMAE Antibody-Drug Conjugate DMUC4064A + - Anti-MUC17/CD3 BiTE Antibody AMG 199 + - Anti-Myeloma Monoclonal Antibody-DM4 Immunoconjugate BT-062 + - Anti-myostatin Monoclonal Antibody LY2495655 + - Anti-NaPi2b Antibody-drug Conjugate XMT-1592 + - Anti-NaPi2b Monoclonal Antibody XMT-1535 + - Anti-nectin-4 Monoclonal Antibody-Drug Conjugate AGS-22M6E + - Anti-Neuropilin-1 Monoclonal Antibody MNRP1685A + - Anti-nf-P2X7 Antibody Ointment BIL-010t + - Anti-NRP1 Antibody ASP1948 + - Anti-Nucleolin Aptamer AS1411 + - Anti-NY-ESO1/LAGE-1A TCR/scFv Anti-CD3 IMCnyeso + - Anti-NY-ESO-1 Immunotherapeutic GSK-2241658A + - Anti-OFA Immunotherapeutic BB-MPI-03 + - Anti-OX40 Agonist Monoclonal Antibody ABBV-368 + - Anti-OX40 Agonist Monoclonal Antibody BGB-A445 + - Anti-OX40 Agonist Monoclonal Antibody PF-04518600 + - Anti-OX40 Antibody BMS 986178 + - Anti-OX40 Hexavalent Agonist Antibody INBRX-106 + - Anti-OX40 Monoclonal Antibody GSK3174998 + - Anti-OX40 Monoclonal Antibody IBI101 + - Anti-PD1 Monoclonal Antibody AGEN2034 + - Anti-PD1/CTLA4 Bispecific Antibody XmAb20717 + - Anti-PD-1 Antibody-interleukin-21 Mutein Fusion Protein AMG 256 + - Anti-PD-1 Checkpoint Inhibitor PF-06801591 + - Anti-PD-1 Fusion Protein AMP-224 + - Anti-PD-1 Monoclonal Antibody 609A + - Anti-PD-1 Monoclonal Antibody AK105 + - Anti-PD-1 Monoclonal Antibody AMG 404 + - Anti-PD-1 Monoclonal Antibody BAT1306 + - Anti-PD-1 Monoclonal Antibody BCD-100 + - Anti-PD-1 Monoclonal Antibody BI 754091 + - Anti-PD-1 Monoclonal Antibody CS1003 + - Anti-PD-1 Monoclonal Antibody F520 + - Anti-PD-1 Monoclonal Antibody GLS-010 + - Anti-PD-1 Monoclonal Antibody HLX10 + - Anti-PD-1 Monoclonal Antibody HX008 + - Anti-PD-1 Monoclonal Antibody JTX-4014 + - Anti-PD-1 Monoclonal Antibody LZM009 + - Anti-PD-1 Monoclonal Antibody MEDI0680 + - Anti-PD-1 Monoclonal Antibody MGA012 + - Anti-PD-1 Monoclonal Antibody SCT-I10A + - Anti-PD-1 Monoclonal Antibody Sym021 + - Anti-PD-1 Monoclonal Antibody TSR-042 + - Anti-PD-1/Anti-CTLA4 DART Protein MGD019 + - Anti-PD-1/Anti-HER2 Bispecific Antibody IBI315 + - Anti-PD-1/Anti-LAG-3 Bispecific Antibody RO7247669 + - Anti-PD-1/Anti-LAG-3 DART Protein MGD013 + - Anti-PD-1/Anti-PD-L1 Bispecific Antibody IBI318 + - Anti-PD-1/Anti-PD-L1 Bispecific Antibody LY3434172 + - Anti-PD-1/CD47 Infusion Protein HX009 + - Anti-PD-1/CTLA-4 Bispecific Antibody AK104 + - Anti-PD-1/CTLA-4 Bispecific Antibody MEDI5752 + - Anti-PD-1/TIM-3 Bispecific Antibody RO7121661 + - Anti-PD-1/VEGF Bispecific Antibody AK112 + - Anti-PD-L1 Monoclonal Antibody A167 + - Anti-PD-L1 Monoclonal Antibody BCD-135 + - Anti-PD-L1 Monoclonal Antibody BGB-A333 + - Anti-PD-L1 Monoclonal Antibody CBT-502 + - Anti-PD-L1 Monoclonal Antibody CK-301 + - Anti-PD-L1 Monoclonal Antibody CS1001 + - Anti-PD-L1 Monoclonal Antibody FAZ053 + - Anti-PD-L1 Monoclonal Antibody GR1405 + - Anti-PD-L1 Monoclonal Antibody HLX20 + - Anti-PD-L1 Monoclonal Antibody IMC-001 + - Anti-PD-L1 Monoclonal Antibody LY3300054 + - Anti-PD-L1 Monoclonal Antibody MDX-1105 + - Anti-PD-L1 Monoclonal Antibody MSB2311 + - Anti-PD-L1 Monoclonal Antibody RC98 + - Anti-PD-L1 Monoclonal Antibody SHR-1316 + - Anti-PD-L1 Monoclonal Antibody TG-1501 + - Anti-PD-L1 Monoclonal Antibody ZKAB001 + - Anti-PD-L1/4-1BB Bispecific Antibody INBRX-105 + - Anti-PD-L1/Anti-4-1BB Bispecific Monoclonal Antibody GEN1046 + - Anti-PD-L1/CD137 Bispecific Antibody MCLA-145 + - Anti-PD-L1/IL-15 Fusion Protein KD033 + - Anti-PD-L1/TIM-3 Bispecific Antibody LY3415244 + - Anti-PGF Monoclonal Antibody RO5323441 + - Anti-PKN3 siRNA Atu027 + - Anti-PLGF Monoclonal Antibody TB-403 + - Anti-PR1/HLA-A2 Monoclonal Antibody Hu8F4 + - Anti-PRAME Immunotherapeutic GSK2302032A + - Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C + - Anti-PRL-3 Monoclonal Antibody PRL3-zumab + - Anti-prolactin Receptor Antibody LFA102 + - Anti-PSCA Monoclonal Antibody AGS-1C4D4 + - Anti-PSMA Monoclonal Antibody MDX1201-A488 + - Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704 + - Anti-PSMA Monoclonal Antibody-MMAE Conjugate + - Anti-PSMA/CD3 Bispecific Antibody CCW702 + - Anti-PSMA/CD3 Bispecific Antibody JNJ-63898081 + - Anti-PSMA/CD3 Monoclonal Antibody MOR209/ES414 + - Anti-PSMA/CD28 Bispecific Antibody REGN5678 + - Anti-PSMA/PBD ADC MEDI3726 + - Anti-PTK7/Auristatin-0101 Antibody-drug Conjugate PF-06647020 + - Anti-PVRIG Monoclonal Antibody COM701 + - Anti-RANKL Monoclonal Antibody GB-223 + - Anti-RANKL Monoclonal Antibody JMT103 + - Anti-Ribonucleoprotein Antibody ATRC-101 + - Anti-ROR1 ADC VLS-101 + - Anti-ROR1/PNU-159682 Derivative Antibody-drug Conjugate NBE-002 + - Anti-S15 Monoclonal Antibody NC318 + - Anti-sCLU Monoclonal Antibody AB-16B5 + - Anti-SIRPa Monoclonal Antibody CC-95251 + - Anti-SLITRK6 Monoclonal Antibody-MMAE Conjugate AGS15E + - Anti-TAG-72 Monoclonal Antibody scFV CC-49/218 + - Anti-TF Monoclonal Antibody ALT-836 + - Anti-TGF-beta Monoclonal Antibody NIS793 + - Anti-TGF-beta Monoclonal Antibody SAR-439459 + - Anti-TGF-beta RII Monoclonal Antibody IMC-TR1 + - Anti-TIGIT Monoclonal Antibody AB154 + - Anti-TIGIT Monoclonal Antibody BGB-A1217 + - Anti-TIGIT Monoclonal Antibody BMS-986207 + - Anti-TIGIT Monoclonal Antibody COM902 + - Anti-TIGIT Monoclonal Antibody OMP-313M32 + - Anti-TIGIT Monoclonal Antibody SGN-TGT + - Anti-TIM3 Monoclonal Antibody LY3321367 + - Anti-TIM3 Monoclonal Antibody SHR-1702 + - Anti-TIM-3 Antibody BMS-986258 + - Anti-TIM-3 Monoclonal Antibody BGB-A425 + - Anti-TIM-3 Monoclonal Antibody INCAGN02390 + - Anti-TIM-3 Monoclonal Antibody MBG453 + - Anti-TIM-3 Monoclonal Antibody Sym023 + - Anti-TIM-3 Monoclonal Antibody TSR-022 + - Anti-Tissue Factor Monoclonal Antibody MORAb-066 + - Anti-TRAILR2/CDH17 Tetravalent Bispecific Antibody BI 905711 + - Anti-TROP2 Antibody-drug Conjugate BAT8003 + - Anti-TROP2 Antibody-drug Conjugate SKB264 + - Anti-TROP2/DXd Antibody-drug Conjugate DS-1062a + - Anti-TWEAK Monoclonal Antibody RG7212 + - Anti-VEGF Anticalin PRS-050-PEG40 + - Anti-VEGF Monoclonal Antibody hPV19 + - Anti-VEGF/ANG2 Nanobody BI 836880 + - Anti-VEGF/TGF-beta 1 Fusion Protein HB-002T + - Anti-VEGFC Monoclonal Antibody VGX-100 + - Anti-VEGFR2 Monoclonal Antibody HLX06 + - Anti-VEGFR2 Monoclonal Antibody MSB0254 + - Anti-VEGFR3 Monoclonal Antibody IMC-3C5 + - Anti-VISTA Monoclonal Antibody JNJ 61610588 + - Antiangiogenic Drug Combination TL-118 + - Antibody-drug Conjugate ABBV-011 + - Antibody-drug Conjugate ABBV-085 + - Antibody-drug Conjugate ABBV-155 + - Antibody-drug Conjugate ABBV-176 + - Antibody-drug Conjugate ABBV-838 + - Antibody-drug Conjugate ADC XMT-1536 + - Antibody-drug Conjugate Anti-TIM-1-vcMMAE CDX-014 + - Antibody-Drug Conjugate DFRF4539A + - Antibody-drug Conjugate MEDI7247 + - Antibody-drug Conjugate PF-06647263 + - Antibody-drug Conjugate PF-06664178 + - Antibody-drug Conjugate SC-002 + - Antibody-drug Conjugate SC-003 + - Antibody-drug Conjugate SC-004 + - Antibody-drug Conjugate SC-005 + - Antibody-drug Conjugate SC-006 + - Antibody-drug Conjugate SC-007 + - Antibody-like CD95 Receptor/Fc-fusion Protein CAN-008 + - Antigen-presenting Cells-expressing HPV16 E6/E7 SQZ-PBMC-HPV + - Antimetabolite FF-10502 + - Antineoplastic Agent Combination SM-88 + - Antineoplastic Vaccine + - Antineoplastic Vaccine GV-1301 + - Antineoplaston A10 + - Antineoplaston AS2-1 + - Antisense Oligonucleotide GTI-2040 + - Antisense Oligonucleotide QR-313 + - Antitumor B Key Active Component-alpha + - Antrodia cinnamomea Supplement + - Antroquinonol Capsule + - Apalutamide + - Apatorsen + - Apaziquone + - APC8015F + - APE1/Ref-1 Redox Inhibitor APX3330 + - Aphidicoline Glycinate + - Apilimod Dimesylate Capsule + - Apitolisib + - Apolizumab + - Apomab + - Apomine + - Apoptosis Inducer BZL101 + - Apoptosis Inducer GCS-100 + - Apoptosis Inducer MPC-2130 + - Apricoxib + - Aprinocarsen + - Aprutumab + - Aprutumab Ixadotin + - AR Antagonist BMS-641988 + - Arabinoxylan Compound MGN3 + - Aranose + - ARC Fusion Protein SL-279252 + - Archexin + - Arcitumomab + - Arfolitixorin + - Arginase Inhibitor INCB001158 + - Arginine Butyrate + - Arnebia Indigo Jade Pearl Topical Cream + - Arsenic Trioxide + - Arsenic Trioxide Capsule Formulation ORH 2014 + - Artemether Sublingual Spray + - Artemisinin Dimer + - Artesunate + - Arugula Seed Powder + - Aryl Hydrocarbon Receptor Antagonist BAY2416964 + - Aryl Hydrocarbon Receptor Inhibitor IK-175 + - Asaley + - Asciminib + - Ascrinvacumab + - Ashwagandha Root Powder Extract + - ASP4132 + - Aspacytarabine + - Asparaginase + - Asparaginase Erwinia chrysanthemi + - Astatine At 211 Anti-CD38 Monoclonal Antibody OKT10-B10 + - Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10 + - Astuprotimut-R + - Asulacrine + - Asulacrine Isethionate + - Asunercept + - At 211 Monoclonal Antibody 81C6 + - Atamestane + - Atezolizumab + - Atiprimod + - Atiprimod Dihydrochloride + - Atiprimod Dimaleate + - ATM Inhibitor M 3541 + - ATM Kinase Inhibitor AZD0156 + - ATM Kinase Inhibitor AZD1390 + - Atorvastatin Calcium + - Atorvastatin Sodium + - ATR Inhibitor RP-3500 + - ATR Kinase Inhibitor BAY1895344 + - ATR Kinase Inhibitor M1774 + - ATR Kinase Inhibitor M6620 + - ATR Kinase Inhibitor VX-803 + - Atrasentan Hydrochloride + - Attenuated Listeria monocytogenes CRS-100 + - Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001 + - Attenuated Measles Virus Encoding SCD Transgene TMV-018 + - Atuveciclib + - Audencel + - Auranofin + - Aurora A Kinase Inhibitor LY3295668 + - Aurora A Kinase Inhibitor LY3295668 Erbumine + - Aurora A Kinase Inhibitor MK5108 + - Aurora A Kinase Inhibitor TAS-119 + - Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076 + - Aurora B Serine/Threonine Kinase Inhibitor TAK-901 + - Aurora B/C Kinase Inhibitor GSK1070916A + - Aurora kinase A/B inhibitor TT-00420 + - Aurora Kinase Inhibitor AMG 900 + - Aurora Kinase Inhibitor BI 811283 + - Aurora Kinase Inhibitor MLN8054 + - Aurora Kinase Inhibitor PF-03814735 + - Aurora Kinase Inhibitor SNS-314 + - Aurora Kinase Inhibitor TTP607 + - Aurora Kinase/VEGFR2 Inhibitor CYC116 + - Autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707 + - Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055 + - Autologous Anti-BCMA CAR T-cells PHE885 + - Autologous Anti-BCMA CAR-transduced T-cells KITE-585 + - Autologous Anti-BCMA CD8+ CAR T-cells Descartes-11 + - Autologous Anti-BCMA-CAR Expressing Stem Memory T-cells P-BCMA-101 + - Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing CD4+/CD8+ T-lymphocytes + JCARH125 + - Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing Memory T-lymphocytes bb21217 + - Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088 + - Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells CT053 + - Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143 + - Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx + - Autologous Anti-CD19 CAR T-cells IM19 + - Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes huCART19 + - Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19 + - Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01 + - Autologous Anti-CD19 CAR-CD28 T-cells ET019002 + - Autologous Anti-CD19 CAR-expressing T-lymphocytes CLIC-1901 + - Autologous Anti-CD19 Chimeric Antigen Receptor T-cells AUTO1 + - Autologous Anti-CD19 Chimeric Antigen Receptor T-cells SJCAR19 + - Autologous Anti-CD19 T-cell Receptor T cells ET190L1 + - Autologous Anti-CD19 TAC-T cells TAC01-CD19 + - Autologous Anti-CD19/CD20 Bispecific Nanobody-based CAR-T cells + - Autologous Anti-CD19/CD22 CAR T-cells AUTO3 + - Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ Central Memory + T-lymphocytes JCAR014 + - Autologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells + - Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1 + - Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s + - Autologous Anti-CD123 CAR-T Cells + - Autologous Anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes + - Autologous Anti-FLT3 CAR T Cells AMG 553 + - Autologous Anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202 + - Autologous Anti-HLA-A*0201/AFP CAR T-cells ET1402L1 + - Autologous Anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T-cells AIC100 + - Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes + - Autologous Anti-NY-ESO-1/LAGE-1 TCR-transduced c259 T Lymphocytes GSK3377794 + - Autologous Anti-PD-1 Antibody-activated Tumor-infiltrating Lymphocytes + - Autologous Anti-PSMA CAR-T Cells P-PSMA-101 + - Autologous AXL-targeted CAR T-cells CCT301-38 + - Autologous B-cell/Monocyte-presenting HER2/neu Antigen Vaccine BVAC-B + - Autologous BCMA-targeted CAR T Cells CC-98633 + - Autologous BCMA-targeted CAR T Cells LCAR-B4822M + - Autologous Bi-epitope BCMA-targeted CAR T-cells JNJ-68284528 + - Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F + - Autologous Bispecific CD19/CD22-targeted CAR-T Cells GC022 + - Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001 + - Autologous CAR-mbIL15-Safety Switch T-cells PRGN-3005 + - Autologous CAR-mbIL15-Safety Switch T-cells PRGN-3006 + - Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1 + - Autologous CD19-targeted CAR T Cells CC-97540 + - Autologous CD19-targeted CAR T Cells JWCAR029 + - Autologous CD19-targeted CAR-T Cells GC007F + - Autologous CD19/PD-1 Bispecific CAR-T Cells + - Autologous CD20-4SCAR-expressing T-cells 4SCAR20 + - Autologous CD22-4SCAR-expressing T-cells 4SCAR22 + - Autologous CD38-4SCAR-expressing T-cells 4SCAR38 + - Autologous CD123-4SCAR-expressing T-cells 4SCAR123 + - Autologous Clonal Neoantigen T Cells ATL001 + - Autologous CRISPR-edited Anti-CD19 CAR T Cells XYF19 + - Autologous Deep IL-15 Primed T-cells TRQ15-01 + - Autologous Dendritic Cell Vaccine ACT2001 + - Autologous Dendritic Cell-based Immunotherapeutic AV0113 + - Autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa + - Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Cells + - Autologous Genetically-modified MAGE-A4 C1032 T Cells + - Autologous Heat-Shock Protein 70 Peptide Vaccine AG-858 + - Autologous HPV16 E7-specific HLA-A*02:01-restricted TCR Gene Engineered Lymphocytes + KITE-439 + - Autologous LMP1/LMP2/EBNA1-specific HLA-A02:01/24:02/11:01-restricted TCR-expressing + T-lymphocytes YT-E001 + - Autologous MAGE-A3/A6-specific TCR Gene-engineered Lymphocytes KITE-718 + - Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ + T-cells FH-MCVA2TCR + - Autologous Mesenchymal Stem Cells Apceth_101 + - Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11 + - Autologous Monocyte-derived Lysate-pulsed Dendritic Cell Vaccine PV-001-DC + - Autologous Multi-lineage Potential Cells + - Autologous Nectin-4/FAP-targeted CAR-T Cells + - Autologous NKG2D CAR T-cells CYAD-02 + - Autologous NKG2D CAR-CD3zeta-DAP10-expressing T-Lymphocytes CYAD-01 + - Autologous Pancreatic Adenocarcinoma Lysate and mRNA-loaded Dendritic Cell + Vaccine + - Autologous Peripheral Blood Lymphocytes from Ibrutinib-treated Chronic Lymphocytic + Leukemia Patients IOV-2001 + - Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101 + - Autologous Prostate Stem Cell Antigen-specific CAR T Cells BPX-601 + - Autologous Rapamycin-resistant Th1/Tc1 Cells RAPA-201 + - Autologous ROR2-targeted CAR T-cells CCT301-59 + - Autologous TAAs-loaded Autologous Dendritic Cells AV-GBM-1 + - Autologous TCR-engineered T-cells IMA201 + - Autologous TCR-engineered T-cells IMA202 + - Autologous TCR-engineered T-cells IMA203 + - Autologous TCRm-expressing T-cells ET140203 + - Autologous Tetravalent Dendritic Cell Vaccine MIDRIX4-LUNG + - Autologous Tumor Infiltrating Lymphocytes LN-144 + - Autologous Tumor Infiltrating Lymphocytes LN-145 + - Autologous Tumor Infiltrating Lymphocytes LN-145-S1 + - Autologous Tumor Infiltrating Lymphocytes MDA-TIL + - Autologous Universal CAR-expressing T-lymphocytes UniCAR02-T + - Avadomide + - Avadomide Hydrochloride + - Avapritinib + - Avdoralimab + - Avelumab + - Aviscumine + - Avitinib Maleate + - Axalimogene Filolisbac + - Axatilimab + - Axicabtagene Ciloleucel + - Axitinib + - AXL Inhibitor DS-1205c + - AXL Inhibitor SLC-391 + - AXL Receptor Tyrosine Kinase/cMET Inhibitor BPI-9016M + - AXL/ FLT3/VEGFR2 Inhibitor KC1036 + - Axl/Mer Inhibitor INCB081776 + - Axl/Mer Inhibitor PF-07265807 + - Azacitidine + - Azapicyl + - Azaribine + - Azaserine + - Azathioprine + - Azimexon + - Azintuxizumab Vedotin + - Aziridinylbenzoquinone RH1 + - Azotomycin + - Azurin:50-77 Cell Penetrating Peptide p28 + - B-Raf/VEGFR-2 Inhibitor RAF265 + - Babaodan Capsule + - Bacillus Calmette-Guerin Substrain Connaught Live Antigen + - Bactobolin + - Bafetinib + - Balixafortide + - Balstilimab + - Baltaleucel-T + - Banoxantrone + - Barasertib + - Bardoxolone + - Bardoxolone Methyl + - Baricitinib + - Batabulin + - Batabulin Sodium + - Batimastat + - Bavituximab + - Bazedoxifene + - Bazlitoran + - BC-819 Plasmid/Polyethylenimine Complex + - BCG Solution + - BCG Tokyo-172 Strain Solution + - BCG Vaccine + - Bcl-2 Inhibitor APG 2575 + - Bcl-2 Inhibitor BCL201 + - Bcl-2 Inhibitor BGB-11417 + - Bcl-2 Inhibitor LP-108 + - Bcl-2 Inhibitor S65487 + - Bcl-Xs Adenovirus Vaccine + - BCMA x CD3 T-cell Engaging Antibody CC-93269 + - BCMA-CD19 Compound CAR T Cells + - BCMA/CD3e Tri-specific T-cell Activating Construct HPN217 + - Bcr-Abl Kinase Inhibitor K0706 + - Bcr-Abl Kinase Inhibitor PF-114 + - BCR-ABL/KIT/AKT/ERK Inhibitor HQP1351 + - Beauvericin + - Becatecarin + - Belagenpumatucel-L + - Belantamab Mafodotin + - Belapectin + - Belimumab + - Belinostat + - Belotecan Hydrochloride + - Belvarafenib + - Belzutifan + - Bemarituzumab + - Bemcentinib + - Bempegaldesleukin + - Benaxibine + - Bendamustine + - Bendamustine Hydrochloride + - Bendamustine-containing Nanoparticle-based Formulation RXDX-107 + - Benzaldehyde Dimethane Sulfonate + - Benzoylphenylurea + - Berberine Chloride + - Bermekimab + - Bersanlimab + - Berubicin Hydrochloride + - Berzosertib + - BET Bromodomain Inhibitor ZEN-3694 + - BET Inhibitor ABBV-744 + - BET Inhibitor BAY1238097 + - BET inhibitor BI 894999 + - BET Inhibitor BMS-986158 + - BET Inhibitor CC-90010 + - BET Inhibitor CPI-0610 + - BET Inhibitor FT-1101 + - BET Inhibitor GS-5829 + - BET Inhibitor GSK2820151 + - BET Inhibitor INCB054329 + - BET Inhibitor INCB057643 + - BET Inhibitor RO6870810 + - BET-bromodomain Inhibitor ODM-207 + - Beta Alethine + - Beta-Carotene + - Beta-elemene + - Beta-Glucan + - Beta-Glucan MM-10-001 + - Beta-lapachone Prodrug ARQ 761 + - Beta-Thioguanine Deoxyriboside + - Betaglucin Gel + - Betulinic Acid + - Bevacizumab + - Bexarotene + - Bexmarilimab + - BF-200 Gel Formulation + - BH3 Mimetic ABT-737 + - Bi-functional Alkylating Agent VAL-083 + - Bicalutamide + - Bimiralisib + - Binetrakin + - Binimetinib + - Bintrafusp Alfa + - Birabresib + - Birinapant + - Bis(choline)tetrathiomolybdate + - Bisantrene + - Bisantrene Hydrochloride + - Bisnafide + - Bisnafide Dimesylate + - Bispecific Antibody 2B1 + - Bispecific Antibody AGEN1223 + - Bispecific Antibody AMG 509 + - Bispecific Antibody GS-1423 + - Bispecific Antibody MDX447 + - Bispecific Antibody MDX-H210 + - Bisthianostat + - BiTE Antibody AMG 910 + - Bivalent BRD4 Inhibitor AZD5153 + - Bizalimogene Ralaplasmid + - Bizelesin + - BL22 Immunotoxin + - Black Cohosh + - Black Raspberry Nectar + - Bleomycin + - Bleomycin A2 + - Bleomycin B2 + - Bleomycin Sulfate + - Blinatumomab + - Blueberry Powder Supplement + - BMI1 Inhibitor PTC596 + - BMS-184476 + - BMS-188797 + - BMS-214662 + - BMS-275183 + - Boanmycin Hydrochloride + - Bomedemstat + - Boronophenylalanine-Fructose Complex + - Bortezomib + - Bosutinib + - Bosutinib Monohydrate + - Botanical Agent BEL-X-HG + - Botanical Agent LEAC-102 + - Bovine Cartilage + - Bozitinib + - BP-Cx1-Platinum Complex BP-C1 + - BR96-Doxorubicin Immunoconjugate + - Brachyury-expressing Yeast Vaccine GI-6301 + - BRAF Inhibitor + - BRAF Inhibitor ARQ 736 + - BRAF Inhibitor BGB-3245 + - BRAF Inhibitor PLX8394 + - BRAF(V600E) Kinase Inhibitor ABM-1310 + - BRAF(V600E) Kinase Inhibitor RO5212054 + - BRAF/EGFR Inhibitor BGB-283 + - BRAFV600/PI3K Inhibitor ASN003 + - BRD4 Inhibitor PLX2853 + - BRD4 Inhibitor PLX51107 + - Breflate + - Brentuximab + - Brentuximab Vedotin + - Brequinar + - Brequinar Sodium + - Briciclib Sodium + - Brigatinib + - Brilanestrant + - Brimonidine Tartrate Nanoemulsion OCU-300 + - Brivanib + - Brivanib Alaninate + - Brivudine + - Brivudine Phosphoramidate + - Broad-Spectrum Human Papillomavirus Vaccine V505 + - Broccoli Sprout/Broccoli Seed Extract Supplement + - Bromacrylide + - Bromebric Acid + - Bromocriptine Mesylate + - Brontictuzumab + - Brostacillin Hydrochloride + - Brostallicin + - Broxuridine + - Bruceanol A + - Bruceanol B + - Bruceanol C + - Bruceanol D + - Bruceanol E + - Bruceanol F + - Bruceanol G + - Bruceanol H + - Bruceantin + - Bryostatin 1 + - BTK Inhibitor ARQ 531 + - BTK Inhibitor CT-1530 + - BTK Inhibitor DTRMWXHS-12 + - BTK Inhibitor HZ-A-018 + - BTK Inhibitor ICP-022 + - BTK Inhibitor LOXO-305 + - BTK Inhibitor M7583 + - BTK inhibitor TG-1701 + - Budigalimab + - Budotitane + - Bufalin + - Buparlisib + - Burixafor + - Burixafor Hydrobromide + - Burosumab + - Buserelin + - Bushen Culuan Decoction + - Bushen-Jianpi Decoction + - Busulfan + - Buthionine Sulfoximine + - BXQ-350 Nanovesicle Formulation + - c-Kit Inhibitor PLX9486 + - c-Met Inhibitor ABN401 + - c-Met Inhibitor AL2846 + - c-Met Inhibitor AMG 208 + - c-Met Inhibitor AMG 337 + - c-Met Inhibitor GST-HG161 + - c-Met Inhibitor HS-10241 + - c-Met Inhibitor JNJ-38877605 + - c-Met Inhibitor MK2461 + - c-Met Inhibitor MK8033 + - c-Met Inhibitor MSC2156119J + - C-myb Antisense Oligonucleotide G4460 + - c-raf Antisense Oligonucleotide ISIS 5132 + - C-VISA BikDD:Liposome + - C/EBP Beta Antagonist ST101 + - CAB-ROR2-ADC BA3021 + - Cabazitaxel + - Cabiralizumab + - Cabozantinib + - Cabozantinib S-malate + - Cactinomycin + - Caffeic Acid Phenethyl Ester + - CAIX Inhibitor DTP348 + - CAIX Inhibitor SLC-0111 + - Calaspargase Pegol-mknl + - Calcitriol + - Calcium Release-activated Channel Inhibitor CM4620 + - Calcium Release-activated Channels Inhibitor RP4010 + - Calcium Saccharate + - Calculus bovis/Moschus/Olibanum/Myrrha Capsule + - Calicheamicin Gamma 1I + - Camidanlumab Tesirine + - Camptothecin + - Camptothecin Analogue TLC388 + - Camptothecin Glycoconjugate BAY 38-3441 + - Camptothecin Sodium + - Camptothecin-20(S)-O-Propionate Hydrate + - Camrelizumab + - Camsirubicin + - Canakinumab + - Cancell + - Cancer Peptide Vaccine S-588410 + - Canerpaturev + - Canertinib Dihydrochloride + - Canfosfamide + - Canfosfamide Hydrochloride + - Cannabidiol + - Cantrixil + - Cantuzumab Ravtansine + - Capecitabine + - Capecitabine Rapidly Disintegrating Tablet + - Capivasertib + - Capmatinib + - Captopril + - CAR T-Cells AMG 119 + - Caracemide + - Carbendazim + - Carbetimer + - Carbogen + - Carbon C 14-pamiparib + - Carboplatin + - Carboquone + - Carboxyamidotriazole + - Carboxyamidotriazole Orotate + - Carboxyphenyl Retinamide + - Carfilzomib + - Caricotamide/Tretazicar + - Carlumab + - Carmofur + - Carmustine + - Carmustine Implant + - Carmustine in Ethanol + - Carmustine Sustained-Release Implant Wafer + - Carotuximab + - Carubicin + - Carubicin Hydrochloride + - Carzelesin + - Carzinophilin + - Cathelicidin LL-37 + - Cationic Liposome-Encapsulated Paclitaxel + - Cationic Peptide Cream Cypep-1 + - Catumaxomab + - CBP/beta-catenin Antagonist PRI-724 + - CBP/beta-catenin Modulator E7386 + - CCR2 Antagonist CCX872-B + - CCR2 Antagonist PF-04136309 + - CCR2/CCR5 Antagonist BMS-813160 + - CCR4 Inhibitor FLX475 + - CD4-specific Telomerase Peptide Vaccine UCPVax + - CD11b Agonist GB1275 + - CD20-CD19 Compound CAR T Cells + - CD28/ICOS Antagonist ALPN-101 + - CD40 Agonist Monoclonal Antibody CP-870,893 + - CD40 Agonistic Monoclonal Antibody APX005M + - CD44 Targeted Agent SPL-108 + - CD44v6-specific CAR T-cells + - CD47 Antagonist ALX148 + - CD73 Inhibitor AB680 + - CD73 Inhibitor LY3475070 + - CD80-Fc Fusion Protein ALPN-202 + - CD80-Fc Fusion Protein FPT155 + - CD123-CD33 Compound CAR T Cells + - CD123-specific Targeting Module TM123 + - CDC7 Inhibitor TAK-931 + - CDC7 Kinase Inhibitor BMS-863233 + - CDC7 Kinase Inhibitor LY3143921 Hydrate + - CDC7 Kinase Inhibitor NMS-1116354 + - CDK1 Inhibitor BEY1107 + - CDK1/2/4 Inhibitor AG-024322 + - CDK2 Inhibitor PF-07104091 + - CDK2/4/6/FLT3 Inhibitor FN-1501 + - CDK2/5/9 Inhibitor CYC065 + - CDK4 Inhibitor P1446A-05 + - CDK4/6 Inhibitor + - CDK4/6 Inhibitor BPI-16350 + - CDK4/6 Inhibitor CS3002 + - CDK4/6 Inhibitor FCN-437 + - CDK4/6 Inhibitor G1T38 + - CDK4/6 Inhibitor HS-10342 + - CDK4/6 Inhibitor SHR6390 + - CDK4/6 Inhibitor TQB3616 + - CDK7 Inhibitor CT7001 + - CDK7 Inhibitor SY-1365 + - CDK7 Inhibitor SY-5609 + - CDK8/19 Inhibitor SEL 120 + - CDK9 Inhibitor AZD4573 + - CDK Inhibitor AT7519 + - CDK Inhibitor R547 + - CDK Inhibitor SNS-032 + - CDK/JAK2/FLT3 Inhibitor TG02 Citrate + - CEA-MUC-1-TRICOM Vaccine CV301 + - CEA-targeting Agent RG6123 + - CEBPA-targeting saRNA MTL-CEBPA Liposome + - Cedazuridine + - Cedazuridine/Azacitidine Combination Agent ASTX030 + - Cedazuridine/Decitabine Combination Agent ASTX727 + - Cedefingol + - Cediranib + - Cediranib Maleate + - Celecoxib + - Cell Cycle Checkpoint/DNA Repair Antagonist IC83 + - Cemadotin + - Cemadotin Hydrochloride + - Cemiplimab + - Cenersen + - Cenisertib + - CENP-E Inhibitor GSK-923295 + - Ceralasertib + - Ceramide Nanoliposome + - Cerdulatinib + - Cereblon E3 Ubiquitin Ligase Modulating Agent CC-92480 + - Cereblon E3 Ubiquitin Ligase Modulating Agent CC-99282 + - Cereblon Modulator CC-90009 + - Cergutuzumab Amunaleukin + - Ceritinib + - Cesalin + - cEt KRAS Antisense Oligonucleotide AZD4785 + - Cetrelimab + - Cetuximab + - Cetuximab Sarotalocan + - Cetuximab-IR700 Conjugate RM-1929 + - Cetuximab-loaded Ethylcellulose Polymeric Nanoparticles Decorated with Octreotide + (SY) + - Cevipabulin + - Cevipabulin Fumarate + - Cevipabulin Succinate + - Cevostamab + - cFMS Tyrosine Kinase Inhibitor ARRY-382 + - Chaparrin + - Chaparrinone + - Checkpoint Kinase Inhibitor AZD7762 + - Checkpoint Kinase Inhibitor XL844 + - Chemotherapy + - Chiauranib + - Chimeric Monoclonal Antibody 81C6 + - ChiNing Decoction + - Chk1 Inhibitor CCT245737 + - Chk1 Inhibitor GDC-0425 + - Chk1 Inhibitor GDC-0575 + - CHK1 Inhibitor MK-8776 + - CHK1 Inhibitor PF-477736 + - Chlorambucil + - Chlorodihydropyrimidine + - Chloroquine + - Chloroquinoxaline Sulfonamide + - Chlorotoxin + - Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes + - Chlorozotocin + - Choline Kinase Alpha Inhibitor TCD-717 + - CHP-NY-ESO-1 Peptide Vaccine IMF-001 + - Chromomycin A3 + - Chrysanthemum morifolium/Ganoderma lucidum/Glycyrrhiza glabra/Isatis indigotica/Panax + pseudoginseng/Rabdosia rubescens/Scutellaria baicalensis/Serona repens Supplement + - Cibisatamab + - Ciclopirox Prodrug CPX-POM + - Cidan Herbal Capsule + - Cidofovir + - Ciforadenant + - Cilengitide + - Ciltacabtagene Autoleucel + - Cimetidine + - Cinacalcet Hydrochloride + - Cinobufagin + - Cinobufotalin + - Cinrebafusp Alfa + - Cintirorgon + - Cintredekin Besudotox + - Cirmtuzumab + - cis-Urocanic Acid + - Cisplatin + - Cisplatin Liposomal + - Cisplatin-E Therapeutic Implant + - Cisplatin/Vinblastine/Cell Penetration Enhancer Formulation INT230-6 + - Citarinostat + - Citatuzumab Bogatox + - Cixutumumab + - CK1alpha/CDK7/CDK9 Inhibitor BTX-A51 + - CK2-targeting Synthetic Peptide CIGB-300 + - CL 246738 + - Cladribine + - Clanfenur + - Clarithromycin + - Class 1/4 Histone Deacetylase Inhibitor OKI-179 + - Clinical Trial + - Clinical Trial Agent + - Clioquinol + - Clivatuzumab + - Clodronate Disodium + - Clodronic Acid + - Clofarabine + - Clomesone + - Clomiphene + - Clomiphene Citrate + - Clostridium Novyi-NT Spores + - Cobimetinib + - Cobolimab + - Cobomarsen + - Codrituzumab + - Coenzyme Q10 + - Cofetuzumab Pelidotin + - Colchicine-Site Binding Agent ABT-751 + - Cold Contaminant-free Iobenguane I-131 + - Colloidal Gold-Bound Tumor Necrosis Factor + - Colorectal Cancer Peptide Vaccine PolyPEPI1018 + - Colorectal Tumor-Associated Peptides Vaccine IMA910 + - Coltuximab Ravtansine + - Combretastatin + - Combretastatin A1 Diphosphate + - Combretastatin A-1 + - Commensal Bacterial Strain Formulation VE800 + - Compound Kushen Injection + - Conatumumab + - Conbercept + - Concentrated Lingzhi Mushroom Extract + - Conditionally Active Biologic Anti-AXL Antibody-drug Conjugate BA3011 + - Copanlisib + - Copanlisib Hydrochloride + - Copper Cu 64-ATSM + - Copper Cu 67 Tyr3-octreotate + - Copper Gluconate + - Cord Blood Derived CAR T-Cells + - Cord Blood-derived Expanded Natural Killer Cells PNK-007 + - Cordycepin + - Cordycepin Triphosphate + - Coriolus Versicolor Extract + - Corticorelin Acetate + - Cortisone Acetate + - Cosibelimab + - Cositecan + - Coxsackievirus A21 + - Coxsackievirus V937 + - CpG Oligodeoxynucleotide GNKG168 + - Crenolanib + - Crenolanib Besylate + - Crizotinib + - Crolibulin + - Cryptophycin + - Cryptophycin 52 + - Crystalline Genistein Formulation AXP107-11 + - CSF1R Inhibitor ABSK021 + - CSF1R Inhibitor DCC-3014 + - CSF1R Inhibitor PLX73086 + - CSF-1R Inhibitor BLZ945 + - CT2584 HMS + - CTLA-4-directed Probody BMS-986249 + - Curcumin + - Curcumin/Doxorubicin-encapsulating Nanoparticle IMX-110 + - Cusatuzumab + - Custirsen Sodium + - CXC Chemokine Receptor 2 Antagonist AZD5069 + - CXCR1/2 Inhibitor SX-682 + - CXCR2 Antagonist QBM076 + - CXCR4 Antagonist BL-8040 + - CXCR4 Antagonist USL311 + - CXCR4 Inhibitor Q-122 + - CXCR4 Peptide Antagonist LY2510924 + - CXCR4/E-selectin Antagonist GMI-1359 + - Cyanocobalamin + - Cyclin-dependent Kinase 8/19 Inhibitor BCD 115 + - Cyclin-dependent Kinase Inhibitor PF-06873600 + - Cyclodextrin-Based Polymer-Camptothecin CRLX101 + - Cyclodisone + - Cycloleucine + - Cyclopentenyl Cytosine + - Cyclophosphamide + - Cyclophosphamide Anhydrous + - Cyclosporine + - CYL-02 Plasmid DNA + - CYP11A1 inhibitor ODM-208 + - CYP11A1 Inhibitor ODM-209 + - CYP17 Inhibitor CFG920 + - CYP17 Lyase Inhibitor ASN001 + - CYP17/Androgen Receptor Inhibitor ODM 204 + - CYP17/CYP11B2 Inhibitor LAE001 + - Cyproterone + - Cyproterone Acetate + - Cytarabine + - Cytarabine Monophosphate Prodrug MB07133 + - Cytarabine-asparagine Prodrug BST-236 + - Cytidine Analog RX-3117 + - Cytochlor + - Cytokine-based Biologic Agent IRX-2 + - D-methionine Formulation MRX-1024 + - DAB389 Epidermal Growth Factor + - Dabrafenib + - Dabrafenib Mesylate + - Dacarbazine + - Dacetuzumab + - DACH Polymer Platinate AP5346 + - DACH-Platin Micelle NC-4016 + - Daclizumab + - Dacomitinib + - Dacplatinum + - Dactinomycin + - Dactolisib + - Dactolisib Tosylate + - Dalantercept + - Dalotuzumab + - Daniquidone + - Danusertib + - Danvatirsen + - Daporinad + - Daratumumab + - Daratumumab and Hyaluronidase-fihj + - Daratumumab/rHuPH20 + - Darinaparsin + - Darleukin + - Darolutamide + - Daromun + - Dasatinib + - Daunorubicin + - Daunorubicin Citrate + - Daunorubicin Hydrochloride + - DEC-205/NY-ESO-1 Fusion Protein CDX-1401 + - Decitabine + - Decitabine and Cedazuridine + - Defactinib + - Defactinib Hydrochloride + - Deferoxamine + - Deferoxamine Mesylate + - Degarelix + - Degarelix Acetate + - Delanzomib + - Delolimogene Mupadenorepvec + - Demcizumab + - Demecolcine + - Demplatin Pegraglumer + - Dendrimer-conjugated Bcl-2/Bcl-XL Inhibitor AZD0466 + - Dendritic Cell Vaccine + - Dendritic Cell-Autologous Lung Tumor Vaccine + - Dendritic Cell-targeting Lentiviral Vector ID-LV305 + - Denenicokin + - Dengue Virus Adjuvant PV-001-DV + - Denibulin + - Denibulin Hydrochloride + - Denileukin Diftitox + - Denintuzumab Mafodotin + - Denosumab + - Deoxycytidine Analogue TAS-109 + - Deoxycytidine Analogue TAS-109 Hydrochloride + - Depatuxizumab + - Depatuxizumab Mafodotin + - Derazantinib + - Deslorelin + - Deslorelin Acetate + - Detirelix + - Detorubicin + - Deuteporfin + - Deuterated Enzalutamide + - Devimistat + - Dexamethason + - Dexamethasone + - Dexamethasone Phosphate + - Dexamethasone Sodium Phosphate + - Dexanabinol + - Dexrazoxane + - Dexrazoxane Hydrochloride + - Dezaguanine + - Dezaguanine Mesylate + - Dezapelisib + - DHA-Paclitaxel + - DHEA Mustard + - DI-Leu16-IL2 Immunocytokine + - Dianhydrogalactitol + - Diarylsulfonylurea Compound ILX-295501 + - Diazepinomicin + - Diaziquone + - Diazooxonorleucine + - Dibrospidium Chloride + - Dichloroallyl Lawsone + - Dicycloplatin + - Didox + - Dienogest + - Diethylnorspermine + - Digitoxin + - Digoxin + - Dihydro-5-Azacytidine + - Dihydrolenperone + - Dihydroorotate Dehydrogenase Inhibitor AG-636 + - Dihydroorotate Dehydrogenase Inhibitor BAY2402234 + - Diindolylmethane + - Dilpacimab + - Dimethylmyleran + - Dinaciclib + - Dinutuximab + - Dioscorea nipponica Makino Extract DNE3 + - Diphencyprone + - Diphtheria Toxin Fragment-Interleukin-2 Fusion Protein E7777 + - Ditiocarb + - DKK1-Neutralizing Monoclonal Antibody DKN-01 + - DM4-Conjugated Anti-Cripto Monoclonal Antibody BIIB015 + - DM-CHOC-PEN + - DNA Interference Oligonucleotide PNT2258 + - DNA Minor Groove Binding Agent SG2000 + - DNA Plasmid Encoding Interleukin-12 INO-9012 + - DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 + Formulation INO-5151 + - DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457 + - DNA Vaccine VB10.16 + - DNA-dependent Protein Kinase Inhibitor VX-984 + - DNA-PK inhibitor AZD7648 + - DNA-PK/PI3K-delta Inhibitor BR101801 + - DNA-PK/TOR Kinase Inhibitor CC-115 + - DNMT1 Inhibitor NTX-301 + - DNMT1 Mixed-Backbone Antisense Oligonucleotide MG 98 + - Docetaxel + - Docetaxel Anhydrous + - Docetaxel Emulsion ANX-514 + - Docetaxel Formulation CKD-810 + - Docetaxel Lipid Microspheres + - Docetaxel Nanoparticle CPC634 + - Docetaxel Polymeric Micelles + - Docetaxel-loaded Nanopharmaceutical CRLX301 + - Docetaxel-PNP + - Docetaxel/Ritonavir + - Dociparstat sodium + - Dolastatin 10 + - Dolastatin 15 + - Domatinostat + - Donafenib + - Dopamine-Somatostatin Chimeric Molecule BIM-23A760 + - Dostarlimab + - Double-armed TMZ-CD40L/4-1BBL Oncolytic Ad5/35 Adenovirus LOAd703 + - Dovitinib + - Dovitinib Lactate + - Doxazosin + - Doxercalciferol + - Doxifluridine + - Doxorubicin + - Doxorubicin Hydrochloride + - Doxorubicin Prodrug L-377,202 + - Doxorubicin Prodrug/Prodrug-activating Biomaterial SQ3370 + - Doxorubicin-Eluting Beads + - Doxorubicin-HPMA Conjugate + - Doxorubicin-loaded EGFR-targeting Nanocells + - Doxorubicin-Magnetic Targeted Carrier Complex + - DPT/BCG/Measles/Serratia/Pneumococcus Vaccine + - DPT/Typhoid/Staphylococcus aureus/Paratyphoid A/Paratyphoid B Vaccine + - DPX-E7 HPV Vaccine + - DR5 HexaBody Agonist GEN1029 + - DR5-targeting Tetrameric Nanobody Agonist TAS266 + - Dromostanolone Propionate + - Drozitumab + - DTRMWXHS-12/Everolimus/Pomalidomide Combination Agent DTRM-555 + - Dual IGF-1R/InsR Inhibitor BMS-754807 + - Dual Variable Domain Immunoglobulin ABT-165 + - Dual-affinity B7-H3/CD3-targeted Protein MGD009 + - Dubermatinib + - Duborimycin + - Dulanermin + - Duligotuzumab + - Dupilumab + - Durvalumab + - Dusigitumab + - dUTPase/DPD Inhibitor TAS-114 + - Duvelisib + - Duvortuxizumab + - Dynemicin + - Dynemicin A + - E2F1 Pathway Activator ARQ 171 + - EBNA-1 inhibitor VK-2019 + - Echinomycin + - Ecromeximab + - Edatrexate + - Edelfosine + - Edicotinib + - Edodekin alfa + - Edotecarin + - Edrecolomab + - EED Inhibitor MAK683 + - Efatutazone + - Efatutazone Dihydrochloride + - Efizonerimod + - Eflornithine + - Eflornithine Hydrochloride + - Eftilagimod Alpha + - Eftozanermin Alfa + - Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205 + - Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621 + - EGb761 + - EGFR Antagonist Hemay022 + - EGFR Antisense DNA BB-401 + - EGFR Inhibitor AZD3759 + - EGFR Inhibitor BIBX 1382 + - EGFR Inhibitor DBPR112 + - EGFR Inhibitor PD-168393 + - EGFR Inhibitor TY-9591 + - EGFR Mutant-selective Inhibitor TQB3804 + - EGFR Mutant-specific Inhibitor BPI-7711 + - EGFR Mutant-specific Inhibitor CK-101 + - EGFR Mutant-specific Inhibitor D-0316 + - EGFR Mutant-specific Inhibitor ZN-e4 + - EGFR T790M Antagonist BPI-15086 + - EGFR T790M Inhibitor HS-10296 + - EGFR/EGFRvIII Inhibitor WSD0922-FU + - EGFR/FLT3/Abl Inhibitor SKLB1028 + - EGFR/HER1/HER2 Inhibitor PKI166 + - EGFR/HER2 Inhibitor AP32788 + - EGFR/HER2 Inhibitor AV-412 + - EGFR/HER2 Inhibitor DZD9008 + - EGFR/HER2 Kinase Inhibitor TAK-285 + - EGFR/TGFb Fusion Monoclonal Antibody BCA101 + - EGFR/VEGFR/RET Inhibitor HA121-28 + - Eicosapentaenoic Acid + - eIF4E Antisense Oligonucleotide ISIS 183750 + - Elacestrant + - Elacytarabine + - Elagolix + - Elbasvir/Grazoprevir + - Elesclomol + - Elesclomol Sodium + - Elgemtumab + - Elinafide + - Elisidepsin + - Elliptinium + - Elliptinium Acetate + - Elmustine + - Elotuzumab + - Elpamotide + - Elsamitrucin + - Eltanexor + - Emactuzumab + - Emapalumab + - Emepepimut-S + - Emibetuzumab + - Emitefur + - Emofolin Sodium + - Empesertib + - Enadenotucirev + - Enadenotucirev-expressing Anti-CD40 Agonistic Monoclonal Antibody NG-350A + - Enadenotucirev-expressing FAP/CD3 Bispecific FAP-TAc NG-641 + - Enasidenib + - Enasidenib Mesylate + - Enavatuzumab + - Encapsulated Rapamycin + - Encelimab + - Enclomiphene + - Enclomiphene Citrate + - Encorafenib + - Endothelin B Receptor Blocker ENB 003 + - Endothelin Receptor Type A Antagonist YM598 + - Enfortumab Vedotin + - Engineered Human Umbilical Vein Endothelial Cells AB-205 + - Engineered Red Blood Cells Co-expressing 4-1BBL and IL-15TP RTX-240 + - Engineered Toxin Body Targeting CD38 TAK-169 + - Engineered Toxin Body Targeting HER2 MT-5111 + - Eniluracil/5-FU Combination Tablet + - Enloplatin + - Enoblituzumab + - Enobosarm + - Enoticumab + - Enpromate + - Ensartinib + - Ensituximab + - Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride + - Enterococcus gallinarum Strain MRx0518 + - Entinostat + - Entolimod + - Entospletinib + - Entrectinib + - Envafolimab + - Enzalutamide + - Enzastaurin + - Enzastaurin Hydrochloride + - EP2/EP4 Antagonist TPST-1495 + - EP4 Antagonist INV-1120 + - EP4 Antagonist ONO-4578 + - Epacadostat + - Epcoritamab + - EphA2-targeting Bicycle Toxin Conjugate BT5528 + - Epipodophyllotoxin Analog GL331 + - Epipropidine + - Epirubicin + - Epirubicin Hydrochloride + - Epitinib Succinate + - Epitiostanol + - Epothilone Analog UTD1 + - Epothilone KOS-1584 + - Epratuzumab + - Epratuzumab-cys-tesirine + - ER alpha Proteolysis-targeting Chimera Protein Degrader ARV-471 + - ERa36 Modulator Icaritin + - Erastin Analogue PRLX 93936 + - Erbulozole + - Erdafitinib + - Eribulin + - Eribulin Mesylate + - ERK1/2 Inhibitor ASN007 + - ERK1/2 Inhibitor HH2710 + - ERK1/2 Inhibitor JSI-1187 + - ERK1/2 Inhibitor KO-947 + - ERK1/2 Inhibitor LY3214996 + - ERK 1/2 Inhibitor ASTX029 + - ERK Inhibitor CC-90003 + - ERK Inhibitor GDC-0994 + - ERK Inhibitor LTT462 + - ERK Inhibitor MK-8353 + - Erlotinib + - Erlotinib Hydrochloride + - Ertumaxomab + - Erythrocyte-encapsulated L-asparaginase Suspension + - Esorubicin + - Esorubicin Hydrochloride + - Esperamicin A1 + - Essiac + - Esterified Estrogens + - Estradiol Valerate + - Estramustine + - Estramustine Phosphate Sodium + - Estrogen Receptor Agonist GTx-758 + - Estrogens, Conjugated + - Etalocib + - Etanercept + - Etanidazole + - Etaracizumab + - Etarotene + - Ethaselen + - Ethinyl Estradiol + - Ethyleneimine + - Ethylnitrosourea + - Etidronate-Cytarabine Conjugate MBC-11 + - Etigilimab + - Etirinotecan Pegol + - Etoglucid + - Etoposide + - Etoposide Phosphate + - Etoposide Toniribate + - Etoprine + - Etoricoxib + - Ets-family Transcription Factor Inhibitor TK216 + - Everolimus + - Everolimus Tablets for Oral Suspension + - Evofosfamide + - Ex Vivo-expanded Autologous T Cells IMA101 + - Exatecan Mesylate + - Exatecan Mesylate Anhydrous + - Exemestane + - Exicorilant + - Exisulind + - Extended Release Flucytosine + - Extended Release Metformin Hydrochloride + - Extended-release Onapristone + - Ezabenlimab + - EZH1/2 Inhibitor DS-3201 + - EZH1/2 Inhibitor HH2853 + - EZH2 inhibitor CPI-0209 + - EZH2 Inhibitor CPI-1205 + - EZH2 Inhibitor PF-06821497 + - EZH2 Inhibitor SHR2554 + - F16-IL2 Fusion Protein + - FACT Complex-targeting Curaxin CBL0137 + - Factor VII-targeting Immunoconjugate Protein ICON-1 + - Factor VIIa Inhibitor PCI-27483 + - Fadraciclib + - Fadrozole Hydrochloride + - FAK Inhibitor GSK2256098 + - FAK Inhibitor PF-00562271 + - FAK Inhibitor VS-4718 + - FAK/ALK/ROS1 Inhibitor APG-2449 + - Falimarev + - Famitinib + - FAP/4-1BB-targeting DARPin MP0310 + - FAP/4-1BB-targeting Fusion Protein RO7122290 + - Farletuzumab + - Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123 + - Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells + - Fas Receptor Agonist APO010 + - Fascin Inhibitor NP-G2-044 + - FASN Inhibitor TVB-2640 + - Favezelimab + - Fazarabine + - Fc-engineered Anti-CD40 Agonist Antibody 2141-V11 + - Febuxostat + - Fedratinib + - Fedratinib Hydrochloride + - Feladilimab + - Felzartamab + - Fenebrutinib + - Fenretinide + - Fenretinide Lipid Matrix + - Fenretinide Phospholipid Suspension ST-001 + - FGF Receptor Antagonist HGS1036 + - FGF/FGFR Pathway Inhibitor E7090 + - FGFR1/2/3 Inhibitor HMPL-453 + - FGFR2 Inhibitor RLY-4008 + - FGFR4 Antagonist INCB062079 + - FGFR4 Inhibitor BLU 9931 + - FGFR4 Inhibitor FGF401 + - FGFR4 Inhibitor H3B-6527 + - FGFR4 Inhibitor ICP-105 + - FGFR Inhibitor ASP5878 + - FGFR Inhibitor AZD4547 + - FGFR Inhibitor CPL304110 + - FGFR Inhibitor Debio 1347 + - FGFR Inhibitor TAS-120 + - FGFR/CSF-1R Inhibitor 3D185 + - FGFR/VEGFR/PDGFR/FLT3/SRC Inhibitor XL999 + - Fianlimab + - Fibromun + - Ficlatuzumab + - Figitumumab + - Filanesib + - Filgotinib + - Filgrastim + - Fimaporfin A + - Fimepinostat + - Firtecan Pegol + - Fisogatinib + - Flanvotumab + - Flotetuzumab + - Floxuridine + - FLT3 Inhibitor FF-10101 Succinate + - FLT3 Inhibitor HM43239 + - FLT3 Inhibitor SKI-G-801 + - Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic Vaccinia Virus + RIVAL-01 + - FLT3 Tyrosine Kinase Inhibitor TTT-3002 + - FLT3/ABL/Aurora Kinase Inhibitor KW-2449 + - FLT3/CDK4/6 Inhibitor FLX925 + - FLT3/FGFR Dual Kinase Inhibitor MAX-40279 + - FLT3/KIT Kinase Inhibitor AKN-028 + - FLT3/KIT/CSF1R Inhibitor NMS-03592088 + - Flt3/MerTK Inhibitor MRX-2843 + - Fludarabine + - Fludarabine Phosphate + - Flumatinib + - Flumatinib Mesylate + - Fluorine F 18 Ara-G + - Fluorodopan + - Fluorouracil + - Fluorouracil Implant + - Fluorouracil-E Therapeutic Implant + - Fluoxymesterone + - Flutamide + - Fluvastatin + - Fluvastatin Sodium + - Fluzoparib + - FMS Inhibitor JNJ-40346527 + - Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate + - Folate Receptor Targeted Epothilone BMS753493 + - Folate Receptor-Targeted Tubulysin Conjugate EC1456 + - Folate Receptor-Targeted Vinca Alkaloid EC0489 + - Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225 + - Folate-FITC + - Folic Acid + - Folitixorin + - Foretinib + - Foritinib Succinate + - Formestane + - Forodesine Hydrochloride + - Fosaprepitant + - Fosbretabulin + - Fosbretabulin Disodium + - Fosbretabulin Tromethamine + - Fosgemcitabine Palabenamide + - Fosifloxuridine Nafalbenamide + - Foslinanib + - Foslinanib Disodium + - Fosquidone + - Fostriecin + - Fotemustine + - Fotretamine + - FPV Vaccine CV301 + - FPV-Brachyury-TRICOM Vaccine + - Fresolimumab + - Fruquintinib + - Fulvestrant + - Fumagillin-Derived Polymer Conjugate XMT-1107 + - Fursultiamine + - Futibatinib + - Futuximab + - Futuximab/Modotuximab Mixture + - G Protein-coupled Estrogen Receptor Agonist LNS8801 + - G-Quadruplex Stabilizer BMVC + - Galamustine + - Galarubicin + - Galectin Inhibitor GR-MD-02 + - Galectin-1 Inhibitor OTX008 + - Galeterone + - Galiximab + - Gallium-based Bone Resorption Inhibitor AP-002 + - Galocitabine + - Galunisertib + - Gamboge Resin Extract TSB-9-W1 + - Gamma-delta Tocotrienol + - Gamma-Secretase Inhibitor LY3039478 + - Gamma-Secretase Inhibitor RO4929097 + - Gandotinib + - Ganetespib + - Ganglioside GD2 + - Ganglioside GM2 + - Ganitumab + - Ganoderma lucidum Spores Powder Capsule + - Garlic + - Gastrin Immunotoxin + - Gastrin/cholecystokinin Type B Receptor Inhibitor Z-360 + - Gataparsen Sodium + - Gatipotuzumab + - GBM Antigens and Alloantigens Immunotherapeutic Vaccine + - Gedatolisib + - Gefitinib + - Geldanamycin + - Gelonin + - Gemcitabine + - Gemcitabine Elaidate + - Gemcitabine Hydrochloride + - Gemcitabine Hydrochloride Emulsion + - Gemcitabine Prodrug LY2334737 + - Gemcitabine-Phosphoramidate Hydrochloride NUC-1031 + - Gemcitabine-Releasing Intravesical System + - Gemtuzumab Ozogamicin + - Genetically Modified Interleukin-12 Transgene-encoding Bifidobacterium longum + - Genistein + - Gentuximab + - Geranylgeranyltransferase I Inhibitor + - GI-4000 Vaccine + - Giloralimab + - Gilteritinib + - Gilteritinib Fumarate + - Gimatecan + - Gimeracil + - Ginsenoside Rg3 Capsule + - Giredestrant + - Girentuximab + - Girodazole + - GITR Agonist MEDI1873 + - Givinostat + - Glasdegib + - Glasdegib Maleate + - Glaucarubolone + - Glecaprevir/Pibrentasvir + - Glembatumumab Vedotin + - Glesatinib + - Glioblastoma Cancer Vaccine ERC1671 + - Glioblastoma Multiforme Multipeptide Vaccine IMA950 + - Glioma Lysate Vaccine GBM6-AD + - Glioma-associated Peptide-loaded Dendritic Cell Vaccine SL-701 + - Globo H-DT Vaccine OBI-833 + - Glofitamab + - Glucarpidase + - Glucocorticoid Receptor Antagonist ORIC-101 + - Glufosfamide + - Glumetinib + - Glutaminase Inhibitor CB-839 + - Glutaminase Inhibitor CB-839 Hydrochloride + - Glutaminase Inhibitor IPN60090 + - Glutamine Antagonist DRP-104 + - Glutathione Pegylated Liposomal Doxorubicin Hydrochloride Formulation 2B3-101 + - Glyco-engineered Anti-CD20 Monoclonal Antibody CHO H01 + - Glycooptimized Trastuzumab-GEX + - GM-CSF-encoding Oncolytic Adenovirus CGTG-102 + - Gold Sodium Thiomalate + - Golnerminogene Pradenovec + - Golotimod + - Golvatinib + - Gonadotropin-releasing Hormone Analog + - Goserelin + - Goserelin Acetate + - Goserelin Acetate Extended-release Microspheres LY01005 + - Gossypol + - Gossypol Acetic Acid + - Grapiprant + - Green Tea Extract-based Antioxidant Supplement + - GS/pan-Notch Inhibitor AL101 + - GS/pan-Notch Inhibitor BMS-986115 + - GSK-3 Inhibitor 9-ING-41 + - GSK-3 Inhibitor LY2090314 + - Guadecitabine + - Guanabenz Acetate + - Guselkumab + - Gusperimus Trihydrochloride + - Gutolactone + - H1299 Tumor Cell Lysate Vaccine + - H-ras Antisense Oligodeoxynucleotide ISIS 2503 + - HAAH Lambda phage Vaccine SNS-301 + - Hafnium Oxide-containing Nanoparticles NBTXR3 + - Halichondrin Analogue E7130 + - Halichondrin B + - Halofuginone + - Halofuginone Hydrobromide + - HCV DNA Vaccine INO-8000 + - HDAC6 Inhibitor KA2507 + - HDAC8 Inhibitor NBM-BMX + - HDAC Class I/IIb Inhibitor HG146 + - HDAC Inhibitor AR-42 + - HDAC inhibitor CG200745 + - HDAC Inhibitor CHR-2845 + - HDAC Inhibitor CKD-581 + - HDAC Inhibitor CXD101 + - HDAC Inhibitor MPT0E028 + - HDAC Inhibitor OBP-801 + - HDAC/EGFR/HER2 Inhibitor CUDC-101 + - HDM2 Inhibitor HDM201 + - HDM2 Inhibitor MK-8242 + - Hedgehog Inhibitor IPI-609 + - Hematoporphyrin Derivative + - Hemiasterlin Analog E7974 + - Henatinib Maleate + - Heparan Sulfate Glycosaminoglycan Mimetic M402 + - Heparin Derivative SST0001 + - HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901 + - HER2 Inhibitor CP-724,714 + - HER2 Inhibitor DZD1516 + - HER2 Inhibitor TAS0728 + - HER2 Tri-specific Natural Killer Cell Engager DF1001 + - HER2-directed TLR8 Agonist SBT6050 + - HER2-targeted DARPin MP0274 + - HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302 + - HER2-targeting Antibody Fc Fragment FS102 + - HER-2-positive B-cell Peptide Antigen P467-DT-CRM197/Montanide Vaccine IMU-131 + - Herba Scutellaria Barbata + - Herbimycin + - Heterodimeric Interleukin-15 + - Hexamethylene Bisacetamide + - Hexaminolevulinate + - Hexylresorcinol + - HIF2a RNAi ARO-HIF2 + - HIF-1alpha Inhibitor PX-478 + - HIF-2alpha Inhibitor PT2385 + - HIF-2alpha Inhibitor PT2977 + - Histone-Lysine N-Methyltransferase EZH2 Inhibitor GSK2816126 + - Histrelin Acetate + - HLA-A2-restricted Melanoma-specific Peptides Vaccine GRN-1201 + - HLA-A*0201 Restricted TERT(572Y)/TERT(572) Peptides Vaccine Vx-001 + - HLA-A*2402-Restricted Multipeptide Vaccine S-488410 + - HM2/MMAE Antibody-Drug Conjugate ALT-P7 + - Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine + - Holmium Ho 166 Poly(L-Lactic Acid) Microspheres + - Hormone Therapy + - HPPH + - HPV6/11-targeted DNA Plasmid Vaccine INO-3107 + - HPV16 E7-specific HLA-A*02:01-restricted IgG1-Fc Fusion Protein CUE-101 + - HPV16 L2/E6/E7 Fusion Protein Vaccine TA-CIN + - HPV 16 E6/E7-encoding Arenavirus Vaccine HB-202 + - HPV 16 E7 Antigen-expressing Lactobacillis casei Vaccine BLS-ILB-E710c + - HPV DNA Plasmids Therapeutic Vaccine VGX-3100 + - HPV E6/E7 DNA Vaccine GX-188E + - HPV E6/E7-encoding Arenavirus Vaccine HB-201 + - HPV Types 16/18 E6/E7-Adenoviral Transduced Autologous Lymphocytes/alpha-Galactosylceramide + Vaccine BVAC-C + - HPV-6-targeting Immunotherapeutic Vaccine INO-3106 + - HPV-16 E6 Peptides Vaccine/Candida albicans Extract + - Hsp90 Antagonist KW-2478 + - Hsp90 Inhibitor AB-010 + - Hsp90 Inhibitor BIIB021 + - Hsp90 Inhibitor BIIB028 + - Hsp90 Inhibitor Debio 0932 + - Hsp90 Inhibitor DS-2248 + - Hsp90 Inhibitor HSP990 + - Hsp90 Inhibitor MPC-3100 + - Hsp90 Inhibitor PU-H71 + - Hsp90 Inhibitor SNX-5422 Mesylate + - Hsp90 Inhibitor SNX-5542 Mesylate + - Hsp90 Inhibitor TQB3474 + - Hsp90 Inhibitor XL888 + - Hsp90-targeted Photosensitizer HS-201 + - HSP90-targeted SN-38 Conjugate PEN-866 + - HSP90alpha/beta Inhibitor TAS-116 + - hTERT Multipeptide/Montanide ISA-51 VG/Imiquimod Vaccine GX 301 + - hTERT Vaccine V934/V935 + - hTERT-encoding DNA Vaccine INVAC-1 + - Hu14.18-IL2 Fusion Protein EMD 273063 + - HuaChanSu + - Huaier Extract Granule + - Huang Lian + - huBC1-huIL12 Fusion Protein AS1409 + - Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736 + - Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104 + - Human MOAB LICO 28a32 + - Human Monoclonal Antibody 216 + - Human Monoclonal Antibody B11-hCG Beta Fusion Protein CDX-1307 + - Human Papillomavirus 16 E7 Peptide/Padre 965.10 + - Hyaluronidase-zzxf/Pertuzumab/Trastuzumab + - Hycanthone + - Hydralazine Hydrochloride + - Hydrocortisone Sodium Succinate + - Hydroxychloroquine + - Hydroxyprogesterone Caproate + - Hydroxytyrosol + - Hydroxyurea + - Hypericin + - Hypoxia-activated Prodrug TH-4000 + - I 131 Antiferritin Immunoglobulin + - I 131 Monoclonal Antibody A33 + - I 131 Monoclonal Antibody CC49 + - I 131 Monoclonal Antibody F19 + - I 131 Monoclonal Antibody Lym-1 + - Iadademstat + - Ianalumab + - IAP Inhibitor APG-1387 + - IAP Inhibitor AT-406 + - IAP Inhibitor HGS1029 + - Ibandronate Sodium + - Iberdomide + - Iboctadekin + - Ibritumomab Tiuxetan + - Ibrutinib + - Icotinib Hydrochloride + - Icrucumab + - ICT-121 Dendritic Cell Vaccine + - Idarubicin + - Idarubicin Hydrochloride + - Idarubicin-Eluting Beads + - Idasanutlin + - Idecabtagene Vicleucel + - Idelalisib + - Idetrexed + - IDH1 Mutant Inhibitor LY3410738 + - IDH1(R132) Inhibitor IDH305 + - IDH1R132H-Specific Peptide Vaccine PEPIDH1M + - Idiotype-Pulsed Autologous Dendritic Cell Vaccine APC8020 + - IDO1 Inhibitor KHK2455 + - IDO1 Inhibitor MK-7162 + - IDO1 Inhibitor PF-06840003 + - IDO1/TDO2 Inhibitor DN1406131 + - IDO1/TDO2 Inhibitor M4112 + - IDO Peptide Vaccine IO102 + - IDO-1 Inhibitor LY3381916 + - IDO/TDO Inhibitor HTI-1090 + - IDO/TDO Inhibitor LY-01013 + - Idronoxil + - Idronoxil Suppository NOX66 + - Ieramilimab + - Ifabotuzumab + - Ifetroban + - Ifosfamide + - IGF-1R Inhibitor + - IGF-1R Inhibitor PL225B + - IGF-1R/IR Inhibitor KW-2450 + - IGF-methotrexate Conjugate + - IL4-Pseudomonas Exotoxin Fusion Protein MDNA55 + - IL-2 Recombinant Fusion Protein ALT-801 + - IL-2/9/15 Gamma Chain Receptor Inhibitor BNZ-1 + - IL-10 Immunomodulator MK-1966 + - IL-12-expressing HSV-1 NSC 733972 + - IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051 + - IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000 + - Ilginatinib + - Ilixadencel + - Iloprost + - Ilorasertib + - Imalumab + - Imaradenant + - Imatinib + - Imatinib Mesylate + - Imetelstat + - Imetelstat Sodium + - Imexon + - Imgatuzumab + - Imidazole Mustard + - Imidazole-Pyrazole + - Imifoplatin + - Imipramine Blue + - Imiquimod + - Immediate-release Onapristone + - Immediate-release Tablet Afuresertib + - Immune Checkpoint Inhibitor ASP8374 + - Immunoconjugate RO5479599 + - Immunocytokine NHS-IL2-LT + - Immunocytokine NHS-IL12 + - Immunomodulator LAM-003 + - Immunomodulator OHR/AVR118 + - Immunomodulatory Agent CC-11006 + - Immunomodulatory Oligonucleotide HYB2055 + - Immunotherapeutic Combination Product CMB305 + - Immunotherapeutic GSK1572932A + - Immunotherapy Regimen MKC-1106-MT + - Immunotoxin CMD-193 + - IMT-1012 Immunotherapeutic Vaccine + - Inactivated Oncolytic Virus Particle GEN0101 + - Inalimarev + - Incyclinide + - Indatuximab Ravtansine + - Indibulin + - Indicine-N-Oxide + - Indisulam + - Individualized MVA-based Vaccine TG4050 + - Indocyanine Green-labeled Polymeric Micelles ONM-100 + - Indole-3-Carbinol + - Indomethacin + - Indoximod + - Indoximod Prodrug NLG802 + - Indusatumab Vedotin + - Inebilizumab + - Inecalcitol + - Infigratinib + - Infigratinib Mesylate + - Infliximab + - Ingenol Mebutate + - Ingenol Mebutate Gel + - Iniparib + - iNKT Cell Agonist ABX196 + - Innate Immunostimulator rBBX-01 + - INO-1001 + - Inodiftagene Vixteplasmid + - iNOS Dimerization Inhibitor ASP9853 + - Inosine 5'-monophosphate Dehydrogenase Inhibitor FF-10501-01 + - Inosine Monophosphate Dehydrogenase Inhibitor AVN944 + - Inositol + - Inotuzumab Ozogamicin + - Inproquone + - Integrin alpha-2 Inhibitor E7820 + - Integrin Receptor Antagonist GLPG0187 + - Interferon + - Interferon Alfa-2B + - Interferon Alfa-N1 + - Interferon Alfa-N3 + - Interferon Alfacon-1 + - Interferon Beta-1A + - Interferon Gamma-1b + - Interferon-gamma-expressing Adenovirus Vaccine ASN-002 + - Interleukin Therapy + - Interleukin-2 Liposome + - Interleukin-12-Fc Fusion Protein DF6002 + - Interleukin-15 Agonist Fusion Protein SHR1501 + - Interleukin-15 Fusion Protein BJ-001 + - Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306 + - Interleukin-15/Interleukin-15 Receptor Alpha Sushi+ Domain Fusion Protein + SO-C101 + - Intermediate-affinity Interleukin-2 Receptor Agonist ALKS 4230 + - Intetumumab + - Intiquinatine + - Intoplicine + - Inulin + - Iobenguane I-131 + - Iodine I 124 Monoclonal Antibody A33 + - Iodine I 124 Monoclonal Antibody M5A + - Iodine I 125-Anti-EGFR-425 Monoclonal Antibody + - Iodine I 131 Anti-Fibronectin Antibody Fragment L19-SIP + - Iodine I 131 Apamistamab + - Iodine I 131 Derlotuximab Biotin + - Iodine I 131 Ethiodized Oil + - Iodine I 131 IPA + - Iodine I 131 MIP-1095 + - Iodine I 131 Monoclonal Antibody 81C6 + - Iodine I 131 Monoclonal Antibody BC8 + - Iodine I 131 Monoclonal Antibody CC49-deltaCH2 + - Iodine I 131 Monoclonal Antibody F16SIP + - Iodine I 131 Monoclonal Antibody G-250 + - Iodine I 131 Monoclonal Antibody muJ591 + - Iodine I 131 Omburtamab + - Iodine I 131 Rituximab + - Iodine I 131 Tenatumomab + - Iodine I 131 TM-601 + - Iodine I 131 Tositumomab + - Iodine I-131 + - Ioflubenzamide I-131 + - Ionomycin + - Ipafricept + - Ipatasertib + - Ipilimumab + - Ipomeanol + - Iproplatin + - iPSC-derived CD16-expressing Natural Killer Cells FT516 + - iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596 + - iPSC-derived Natural Killer Cells FT500 + - IRAK4 Inhibitor CA-4948 + - Iratumumab + - Iridium Ir 192 + - Irinotecan + - Irinotecan Hydrochloride + - Irinotecan Sucrosofate + - Irinotecan-Eluting Beads + - Irinotecan/P-glycoprotein Inhibitor HM30181AK Combination Tablet + - Irofulven + - Iroplact + - Irosustat + - Irradiated Allogeneic Human Lung Cancer Cells Expressing OX40L-Ig Vaccine + HS-130 + - Isatuximab + - Iso-fludelone + - Isobrucein B + - Isocoumarin NM-3 + - Isotretinoin + - Ispinesib + - Ispinesib Mesylate + - ISS 1018 CpG Oligodeoxynucleotide + - Istiratumab + - Itacitinib + - Itacitinib Adipate + - ITK Inhibitor CPI-818 + - Itraconazole + - Itraconazole Dispersion In Polymer Matrix + - Ivaltinostat + - Ivosidenib + - Ivuxolimab + - Ixabepilone + - Ixazomib + - Ixazomib Citrate + - JAK1 Inhibitor AZD4205 + - JAK1 Inhibitor INCB052793 + - JAK2 Inhibitor AZD1480 + - JAK2 Inhibitor BMS-911543 + - JAK2 Inhibitor XL019 + - JAK2/Src Inhibitor NS-018 + - JAK Inhibitor + - JAK Inhibitor INCB047986 + - Jin Fu Kang + - JNK Inhibitor CC-401 + - Kanglaite + - Kanitinib + - Ketoconazole + - Ketotrexate + - KRAS G12C Inhibitor GDC-6036 + - KRAS G12C Inhibitor LY3499446 + - KRAS G12C Inhibitor MRTX849 + - KRAS Mutant-targeting AMG 510 + - KRAS-MAPK Signaling Pathway Inhibitor JAB-3312 + - KRASG12C Inhibitor JNJ-74699157 + - KRN5500 + - KSP Inhibitor AZD4877 + - KSP Inhibitor SB-743921 + - Kunecatechins Ointment + - L-Gossypol + - L-methylfolate + - Labetuzumab Govitecan + - Lactoferrin-derived Lytic Peptide LTX-315 + - Lacutamab + - Ladiratuzumab Vedotin + - Ladirubicin + - Laetrile + - LAIR-2 Fusion Protein NC410 + - Landogrozumab + - Laniquidar + - Lanreotide Acetate + - Lapachone + - Lapatinib + - Lapatinib Ditosylate + - Laprituximab Emtansine + - Lapuleucel-T + - Laromustine + - Larotaxel + - Larotinib Mesylate + - Larotrectinib + - Larotrectinib Sulfate + - Lavendustin A + - Lazertinib + - Lead Pb 212 TCMC-trastuzumab + - Lefitolimod + - Leflunomide + - Lenalidomide + - Lenalidomide Analog KPG-121 + - Lentinan + - Lenvatinib + - Lenvatinib Mesylate + - Lenzilumab + - Lerociclib + - Lestaurtinib + - Letetresgene Autoleucel + - Letolizumab + - Letrozole + - Leucovorin + - Leucovorin Calcium + - Leuprolide + - Leuprolide Acetate + - Leuprolide Mesylate Injectable Suspension + - Leurubicin + - Levetiracetam + - Levoleucovorin Calcium + - Levothyroxine + - Levothyroxine Sodium + - Lexatumumab + - Lexibulin + - Liarozole + - Liarozole Fumarate + - Liarozole Hydrochloride + - Licartin + - Licorice + - Lifastuzumab Vedotin + - Lifileucel + - Lifirafenib + - Light-activated AU-011 + - Light-Emitting Oncolytic Vaccinia Virus GL-ONC1 + - Lilotomab + - Limonene, (+)- + - Limonene, (+/-)- + - Linifanib + - Linoleyl Carbonate-Paclitaxel + - Linperlisib + - Linrodostat + - Linsitinib + - Lintuzumab + - Liothyronine I-131 + - Liothyronine Sodium + - Lipid Encapsulated Anti-PLK1 siRNA TKM-PLK1 + - Lipid Nanoparticle Encapsulated mRNAs Encoding Human IL-12A/IL-12B MEDI-1191 + - Lipid Nanoparticle Encapsulated OX40L mRNA-2416 + - Lipid Nanoparticle Encapsulating Glutathione S-transferase P siRNA NBF-006 + - Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L/IL-23/IL-36gamma + mRNA-2752 + - Liposomal Bcl-2 Antisense Oligonucleotide BP1002 + - Liposomal c-raf Antisense Oligonucleotide + - Liposomal Curcumin + - Liposomal Cytarabine + - Liposomal Daunorubicin Citrate + - Liposomal Docetaxel + - Liposomal Eribulin Mesylate + - Liposomal HPV-16 E6/E7 Multipeptide Vaccine PDS0101 + - Liposomal Irinotecan + - Liposomal Mitoxantrone Hydrochloride + - Liposomal MUC1/PET-lipid A Vaccine ONT-10 + - Liposomal NDDP + - Liposomal Rhenium Re 186 + - Liposomal SN-38 + - Liposomal Topotecan FF-10850 + - Liposomal Vinorelbine + - Liposomal Vinorelbine Tartrate + - Liposome + - Liposome-encapsulated Daunorubicin-Cytarabine + - Liposome-Encapsulated Doxorubicin Citrate + - Liposome-encapsulated miR-34 Mimic MRX34 + - Liposome-encapsulated OSI-7904 + - Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94 + - Liposome-encapsulated TAAs mRNA Vaccine W_ova1 + - Lirilumab + - Lisavanbulin + - Lisocabtagene Maraleucel + - Listeria monocytogenes-LLO-PSA Vaccine ADXS31-142 + - Litronesib + - Live-attenuated Double-deleted Listeria monocytogenes Bacteria JNJ-64041809 + - Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207 + - Live-attenuated Listeria monocytogenes-encoding EGFRvIII-NY-ESO-1 Vaccine + ADU-623 + - Liver X Receptor beta Agonist RGX-104 + - Lm-tLLO-neoantigens Vaccine ADXS-NEO + - LMB-1 Immunotoxin + - LMB-2 Immunotoxin + - LMB-7 Immunotoxin + - LMB-9 Immunotoxin + - LmddA-LLO-chHER2 Fusion Protein-secreting Live-attenuated Listeria Cancer + Vaccine ADXS31-164 + - LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes + - LMP7 Inhibitor M3258 + - LMP-2:340-349 Peptide Vaccine + - LMP-2:419-427 Peptide Vaccine + - Lobaplatin + - Lodapolimab + - Lometrexol + - Lometrexol Sodium + - Lomustine + - Lonafarnib + - Loncastuximab Tesirine + - Long Peptide Vaccine 7 + - Long-acting Release Pasireotide + - Lontucirev + - Lorlatinib + - Lorukafusp alfa + - Lorvotuzumab Mertansine + - Losatuxizumab Vedotin + - Losoxantrone + - Losoxantrone Hydrochloride + - Lovastatin + - LOXL2 Inhibitor PAT-1251 + - LRP5 Antagonist BI 905681 + - LRP5/6 Antagonist BI 905677 + - LSD1 Inhibitor CC-90011 + - LSD1 Inhibitor GSK2879552 + - LSD1 Inhibitor IMG-7289 + - LSD1 Inhibitor RO7051790 + - LSD1 Inhibitor SYHA1807 + - Lucanthone + - Lucatumumab + - Lucitanib + - Luminespib + - Luminespib Mesylate + - Lumretuzumab + - Lung-targeted Immunomodulator QBKPN + - Lupartumab Amadotin + - Lurbinectedin + - Lurtotecan + - Lurtotecan Liposome + - Lutetium Lu 177 Anti-CA19-9 Monoclonal Antibody 5B1 + - Lutetium Lu 177 DOTA-biotin + - Lutetium Lu 177 DOTA-N3-CTT1403 + - Lutetium Lu 177 DOTA-Tetulomab + - Lutetium Lu 177 Dotatate + - Lutetium Lu 177 Lilotomab-satetraxetan + - Lutetium Lu 177 Monoclonal Antibody CC49 + - Lutetium Lu 177 Monoclonal Antibody J591 + - Lutetium Lu 177 PP-F11N + - Lutetium Lu 177 Satoreotide Tetraxetan + - Lutetium Lu 177-DOTA-EB-TATE + - Lutetium Lu 177-DTPA-omburtamab + - Lutetium Lu 177-Edotreotide + - Lutetium Lu 177-NeoB + - Lutetium Lu 177-PSMA-617 + - Lutetium Lu-177 Capromab + - Lutetium Lu-177 Girentuximab + - Lutetium Lu-177 PSMA-R2 + - Lutetium Lu-177 Rituximab + - LV.IL-2/B7.1-Transduced AML Blast Vaccine RFUSIN2-AML1 + - Lyophilized Black Raspberry Lozenge + - Lyophilized Black Raspberry Saliva Substitute + - Lysine-specific Demethylase 1 Inhibitor INCB059872 + - Lyso-Thermosensitive Liposome Doxorubicin + - Maackia amurensis Seed Lectin + - Macimorelin + - Macitentan + - Macrocycle-bridged STING Agonist E7766 + - Maekmoondong-tang + - Mafosfamide + - MAGE-10.A2 + - MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells + - MAGE-A3 Multipeptide Vaccine GL-0817 + - MAGE-A3 Peptide Vaccine + - MAGE-A3-specific Immunotherapeutic GSK 2132231A + - MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201 + - Magnesium Valproate + - Magrolimab + - MALT1 Inhibitor JNJ-67856633 + - Manelimab + - Mannosulfan + - Mannosylerythritol Lipid + - Mapatumumab + - Maraba Oncolytic Virus Expressing Mutant HPV E6/E7 + - Marcellomycin + - MARCKS Protein Inhibitor BIO-11006 + - Margetuximab + - Marimastat + - Marizomib + - Masitinib Mesylate + - Masoprocol + - MAT2A Inhibitor AG-270 + - Matrix Metalloproteinase Inhibitor MMI270 + - Matuzumab + - Mavelertinib + - Mavorixafor + - Maytansine + - MCL-1 Inhibitor ABBV-467 + - MCL-1 Inhibitor AMG 176 + - MCL-1 inhibitor AMG 397 + - Mcl-1 Inhibitor AZD5991 + - Mcl-1 Inhibitor MIK665 + - MDM2 Antagonist ASTX295 + - MDM2 Antagonist RO5045337 + - MDM2 Antagonist RO6839921 + - MDM2 Inhibitor AMG-232 + - MDM2 Inhibitor AMGMDS3 + - MDM2 Inhibitor BI 907828 + - MDM2 Inhibitor KRT-232 + - MDM2/MDMX Inhibitor ALRN-6924 + - MDR Modulator CBT-1 + - Mechlorethamine + - Mechlorethamine Hydrochloride + - Mechlorethamine Hydrochloride Gel + - Medorubicin + - Medroxyprogesterone + - Medroxyprogesterone Acetate + - Megestrol Acetate + - MEK 1/2 Inhibitor AS703988/MSC2015103B + - MEK 1/2 Inhibitor FCN-159 + - MEK Inhibitor AZD8330 + - MEK Inhibitor CI-1040 + - MEK inhibitor CS3006 + - MEK Inhibitor GDC-0623 + - MEK Inhibitor HL-085 + - MEK Inhibitor PD0325901 + - MEK Inhibitor RO4987655 + - MEK Inhibitor SHR 7390 + - MEK Inhibitor TAK-733 + - MEK Inhibitor WX-554 + - MEK-1/MEKK-1 Inhibitor E6201 + - MEK/Aurora Kinase Inhibitor BI 847325 + - Melanoma Monoclonal Antibody hIgG2A + - Melanoma TRP2 CTL Epitope Vaccine SCIB1 + - Melapuldencel-T + - MELK Inhibitor OTS167 + - Melphalan + - Melphalan Flufenamide + - Melphalan Hydrochloride + - Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex + - Membrane-Disrupting Peptide EP-100 + - Menatetrenone + - Menin-MLL Interaction Inhibitor SNDX-5613 + - Menogaril + - Merbarone + - Mercaptopurine + - Mercaptopurine Anhydrous + - Mercaptopurine Oral Suspension + - Merestinib + - Mesna + - Mesothelin/CD3e Tri-specific T-cell Activating Construct HPN536 + - MET Kinase Inhibitor OMO-1 + - MET Tyrosine Kinase Inhibitor BMS-777607 + - MET Tyrosine Kinase Inhibitor EMD 1204831 + - MET Tyrosine Kinase Inhibitor PF-04217903 + - MET Tyrosine Kinase Inhibitor SAR125844 + - MET Tyrosine Kinase Inhibitor SGX523 + - MET x MET Bispecific Antibody REGN5093 + - Metamelfalan + - MetAP2 Inhibitor APL-1202 + - MetAP2 Inhibitor SDX-7320 + - Metarrestin + - Metatinib Tromethamine + - Metformin + - Metformin Hydrochloride + - Methanol Extraction Residue of BCG + - Methazolamide + - Methionine Aminopeptidase 2 Inhibitor M8891 + - Methionine Aminopeptidase 2 Inhibitor PPI-2458 + - Methotrexate + - Methotrexate Sodium + - Methotrexate-E Therapeutic Implant + - Methotrexate-Encapsulating Autologous Tumor-Derived Microparticles + - Methoxsalen + - Methoxyamine + - Methoxyamine Hydrochloride + - Methyl-5-Aminolevulinate Hydrochloride Cream + - Methylcantharidimide + - Methylmercaptopurine Riboside + - Methylprednisolone + - Methylprednisolone Acetate + - Methylprednisolone Sodium Succinate + - Methylselenocysteine + - Methyltestosterone + - Metoprine + - Mevociclib + - Mezagitamab + - Mibefradil + - Mibefradil Dihydrochloride + - Micellar Nanoparticle-encapsulated Epirubicin + - Micro Needle Array-Doxorubicin + - Microbiome GEN-001 + - Microbiome-derived Peptide Vaccine EO2401 + - Microparticle-encapsulated CYP1B1-encoding DNA Vaccine ZYC300 + - Microtubule Inhibitor SCB01A + - Midostaurin + - Mifamurtide + - Mifepristone + - Milademetan Tosylate + - Milataxel + - Milatuzumab + - Milatuzumab-Doxorubicin Antibody-Drug Conjugate IMMU-110 + - Milciclib Maleate + - Milk Thistle + - Miltefosine + - Minretumomab + - Mipsagargin + - Miptenalimab + - Mirabegron + - Miransertib + - Mirdametinib + - Mirvetuximab Soravtansine + - Mirzotamab Clezutoclax + - Misonidazole + - Mistletoe Extract + - Mitazalimab + - Mitindomide + - Mitobronitol + - Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101 + - Mitoclomine + - Mitoflaxone + - Mitoguazone + - Mitoguazone Dihydrochloride + - Mitolactol + - Mitomycin + - Mitomycin A + - Mitomycin B + - Mitomycin C Analog KW-2149 + - Mitosis Inhibitor T 1101 Tosylate + - Mitotane + - Mitotenamine + - Mitoxantrone + - Mitoxantrone Hydrochloride + - Mitozolomide + - Mivavotinib + - Mivebresib + - Mivobulin + - Mivobulin Isethionate + - Mixed Bacteria Vaccine + - MK0731 + - MKC-1 + - MKNK1 Inhibitor BAY 1143269 + - MMP Inhibitor S-3304 + - MNK1/2 Inhibitor ETC-1907206 + - Mobocertinib + - Mocetinostat + - Modakafusp Alfa + - Modified Vaccinia Ankara-vectored HPV16/18 Vaccine JNJ-65195208 + - Modified Vitamin D Binding Protein Macrophage Activator EF-022 + - Modotuximab + - MOF Compound RiMO-301 + - Mofarotene + - Mogamulizumab + - Molibresib + - Molibresib Besylate + - Momelotinib + - Monalizumab + - Monocarboxylate Transporter 1 Inhibitor AZD3965 + - Monoclonal Antibody 1F5 + - Monoclonal Antibody 3F8 + - Monoclonal Antibody 3H1 Anti-Idiotype Vaccine + - Monoclonal Antibody 4B5 Anti-Idiotype Vaccine + - Monoclonal Antibody 7C11 + - Monoclonal Antibody 11D10 + - Monoclonal Antibody 11D10 Anti-Idiotype Vaccine + - Monoclonal Antibody 14G2A + - Monoclonal Antibody 81C6 + - Monoclonal Antibody 105AD7 Anti-idiotype Vaccine + - Monoclonal Antibody 3622W94 + - Monoclonal Antibody A1G4 Anti-Idiotype Vaccine + - Monoclonal Antibody A27.15 + - Monoclonal Antibody A33 + - Monoclonal Antibody AbGn-7 + - Monoclonal Antibody AK002 + - Monoclonal Antibody ASP1948 + - Monoclonal Antibody CAL + - Monoclonal Antibody CC49-delta CH2 + - Monoclonal Antibody CEP-37250/KHK2804 + - Monoclonal Antibody D6.12 + - Monoclonal Antibody E2.3 + - Monoclonal Antibody F19 + - Monoclonal Antibody GD2 Anti-Idiotype Vaccine + - Monoclonal Antibody HeFi-1 + - Monoclonal Antibody Hu3S193 + - Monoclonal Antibody HuAFP31 + - Monoclonal Antibody HuHMFG1 + - Monoclonal Antibody huJ591 + - Monoclonal Antibody HuPAM4 + - Monoclonal Antibody IMMU-14 + - Monoclonal Antibody L6 + - Monoclonal Antibody Lym-1 + - Monoclonal Antibody m170 + - Monoclonal Antibody Me1-14 F(ab')2 + - Monoclonal Antibody muJ591 + - Monoclonal Antibody MX35 F(ab')2 + - Monoclonal Antibody NEO-201 + - Monoclonal Antibody R24 + - Monoclonal Antibody RAV12 + - Monoclonal Antibody SGN-14 + - Monoclonal Antibody TRK-950 + - Monoclonal Microbial EDP1503 + - Monoclonal T-cell Receptor Anti-CD3 scFv Fusion Protein IMCgp100 + - Monomethyl Auristatin E + - Morinda Citrifolia Fruit Extract + - Morpholinodoxorubicin + - Mosedipimod + - Mosunetuzumab + - Motesanib + - Motesanib Diphosphate + - Motexafin Gadolinium + - Motexafin Lutetium + - Motixafortide + - Motolimod + - MOv-gamma Chimeric Receptor Gene + - Moxetumomab Pasudotox + - Mps1 Inhibitor BAY 1217389 + - Mps1 Inhibitor BOS172722 + - mRNA-based Personalized Cancer Vaccine mRNA-4157 + - mRNA-based Personalized Cancer Vaccine NCI-4650 + - mRNA-based TriMix Melanoma Vaccine ECI-006 + - mRNA-based Tumor-specific Neoantigen Boosting Vaccine GRT-R902 + - mRNA-derived KRAS-targeted Vaccine V941 + - mRNA-derived Lung Cancer Vaccine BI 1361849 + - mRNA-Derived Prostate Cancer Vaccine CV9103 + - mRNA-derived Prostate Cancer Vaccine CV9104 + - MTF-1 Inhibitor APTO-253 HCl + - mTOR1/2 Kinase Inhibitor ME-344 + - mTOR Inhibitor GDC-0349 + - mTOR Kinase Inhibitor AZD8055 + - mTOR Kinase Inhibitor CC-223 + - mTOR Kinase Inhibitor OSI-027 + - mTOR Kinase Inhibitor PP242 + - mTORC1/2 Kinase Inhibitor BI 860585 + - mTORC1/mTORC2/DHFR Inhibitor ABTL0812 + - mTORC 1/2 Inhibitor LXI-15029 + - MUC1-targeted Peptide GO-203-2C + - MUC-1/WT1 Peptide-primed Autologous Dendritic Cells + - Mucoadhesive Paclitaxel Formulation + - Multi-AGC Kinase Inhibitor AT13148 + - Multi-epitope Anti-folate Receptor Peptide Vaccine TPIV 200 + - Multi-epitope HER2 Peptide Vaccine H2NVAC + - Multi-epitope HER2 Peptide Vaccine TPIV100 + - Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107 + - Multi-kinase Inhibitor TPX-0022 + - Multi-kinase Inhibitor XL092 + - Multi-mode Kinase Inhibitor EOC317 + - Multi-neo-epitope Vaccine OSE 2101 + - Multifunctional/Multitargeted Anticancer Agent OMN54 + - Multikinase Inhibitor 4SC-203 + - Multikinase Inhibitor AEE788 + - Multikinase Inhibitor AT9283 + - Multikinase Inhibitor SAR103168 + - Multipeptide Vaccine S-588210 + - Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327 + - Muparfostat + - Mureletecan + - Murizatoclax + - Muscadine Grape Extract + - Mutant IDH1 Inhibitor DS-1001 + - Mutant p53 Activator COTI-2 + - Mutant-selective EGFR Inhibitor PF-06459988 + - MVA Tumor-specific Neoantigen Boosting Vaccine MVA-209-FSP + - MVA-BN Smallpox Vaccine + - MVA-FCU1 TG4023 + - MVX-1-loaded Macrocapsule/autologous Tumor Cell Vaccine MVX-ONCO-1 + - MYC-targeting siRNA DCR-MYC + - Mycobacterium tuberculosis Arabinomannan Z-100 + - Mycobacterium w + - Mycophenolic Acid + - N,N-Dibenzyl Daunomycin + - N-(5-tert-butyl-3-isoxazolyl)-N-(4-(4-pyridinyl)oxyphenyl) Urea + - N-dihydrogalactochitosan + - N-Methylformamide + - NA17-A Antigen + - NA17.A2 Peptide Vaccine + - Nab-paclitaxel + - Nab-paclitaxel/Rituximab-coated Nanoparticle AR160 + - Nadofaragene Firadenovec + - Nagrestipen + - Namirotene + - Namodenoson + - NAMPT Inhibitor OT-82 + - Nanafrocin + - Nanatinostat + - Nanocell-encapsulated miR-16-based microRNA Mimic + - Nanoparticle Albumin-Bound Docetaxel + - Nanoparticle Albumin-Bound Rapamycin + - Nanoparticle Albumin-bound Thiocolchicine Dimer nab-5404 + - Nanoparticle Paclitaxel Ointment SOR007 + - Nanoparticle-based Paclitaxel Suspension + - Nanoparticle-encapsulated Doxorubicin Hydrochloride + - Nanoscale Coordination Polymer Nanoparticles CPI-100 + - Nanosomal Docetaxel Lipid Suspension + - Napabucasin + - Naphthalimide Analogue UNBS5162 + - Naptumomab Estafenatox + - Naquotinib + - Naratuximab Emtansine + - Narnatumab + - Natalizumab + - Natural IFN-alpha OPC-18 + - Natural Killer Cells ZRx101 + - Navarixin + - Navicixizumab + - Navitoclax + - Navoximod + - Navy Bean Powder + - Naxitamab + - Nazartinib + - ncmtRNA Oligonucleotide Andes-1537 + - Necitumumab + - Nedaplatin + - NEDD8 Activating Enzyme E1 Inhibitor TAS4464 + - Nedisertib + - Nelarabine + - Nelipepimut-S + - Nelipepimut-S Plus GM-CSF Vaccine + - Nemorubicin + - Nemorubicin Hydrochloride + - Neoantigen Vaccine GEN-009 + - Neoantigen-based Glioblastoma Vaccine + - Neoantigen-based Melanoma-Poly-ICLC Vaccine + - Neoantigen-based Renal Cell Carcinoma-Poly-ICLC Vaccine + - Neoantigen-based Therapeutic Cancer Vaccine GRT-C903 + - Neoantigen-based Therapeutic Cancer Vaccine GRT-R904 + - Neoantigen-HSP70 Peptide Cancer Vaccine AGEN2017 + - Neratinib + - Neratinib Maleate + - Nesvacumab + - NG-nitro-L-arginine + - Niacinamide + - Niclosamide + - Nicotinamide Riboside + - Nidanilimab + - Nifurtimox + - Nilotinib + - Nilotinib Hydrochloride Anhydrous + - Nilotinib Hydrochloride Monohydrate + - Nilutamide + - Nimesulide-Hyaluronic Acid Conjugate CA102N + - Nimodipine + - Nimotuzumab + - Nimustine + - Nimustine Hydrochloride + - Ningetinib Tosylate + - Nintedanib + - Niraparib + - Niraparib Tosylate Monohydrate + - Nirogacestat + - Nitric Oxide-Releasing Acetylsalicylic Acid Derivative + - Nitrogen Mustard Prodrug PR-104 + - Nitroglycerin Transdermal Patch + - Nivolumab + - NLRP3 Agonist BMS-986299 + - Nocodazole + - Nogalamycin + - Nogapendekin Alfa + - Nolatrexed Dihydrochloride + - Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201 + - Norgestrel + - North American Ginseng Extract AFX-2 + - Nortopixantrone + - Noscapine + - Noscapine Hydrochloride + - Not Otherwise Specified + - Notch Signaling Inhibitor PF-06650808 + - Notch Signaling Pathway Inhibitor MK0752 + - NTRK/ROS1 Inhibitor DS-6051b + - Nucleolin Antagonist IPP-204106N + - Nucleoside Analog DFP-10917 + - Nucleotide Analog Prodrug NUC-3373 + - Nucleotide Analogue GS 9219 + - Numidargistat + - Nurulimab + - Nutlin-3a + - Nutraceutical TBL-12 + - NY-ESO-1 Plasmid DNA Cancer Vaccine pPJV7611 + - NY-ESO-1-specific TCR Gene-transduced T Lymphocytes TBI-1301 + - NY-ESO-1/GLA-SE Vaccine ID-G305 + - NY-ESO-B + - O6-Benzylguanine + - O-Chloroacetylcarbamoylfumagillol + - Obatoclax Mesylate + - Obinutuzumab + - Oblimersen Sodium + - Ocaratuzumab + - Ocrelizumab + - Octreotide + - Octreotide Acetate + - Octreotide Pamoate + - Odronextamab + - Ofatumumab + - Ofranergene Obadenovec + - Oglufanide Disodium + - Olaparib + - Olaptesed Pegol + - Olaratumab + - Oleandrin + - Oleclumab + - Oligo-fucoidan + - Oligonucleotide SPC2996 + - Olinvacimab + - Olivomycin + - Olmutinib + - Oltipraz + - Olutasidenib + - Olvimulogene Nanivacirepvec + - Omacetaxine Mepesuccinate + - Ombrabulin + - Omipalisib + - Onalespib + - Onalespib Lactate + - Onartuzumab + - Onatasertib + - Oncolytic Adenovirus Ad5-DNX-2401 + - Oncolytic Adenovirus ORCA-010 + - Oncolytic Herpes Simplex Virus-1 ONCR-177 + - Oncolytic HSV1716 + - Oncolytic HSV-1 C134 + - Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011 + - Oncolytic HSV-1 G207 + - Oncolytic HSV-1 NV1020 + - Oncolytic HSV-1 rQNestin34.5v.2 + - Oncolytic HSV-1 rRp450 + - Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating + Protein + - Oncolytic Newcastle Disease Virus MEDI5395 + - Oncolytic Newcastle Disease Virus MTH-68H + - Oncolytic Newcastle Disease Virus Strain PV701 + - Oncolytic Virus ASP9801 + - Oncolytic Virus RP1 + - Ondansetron Hydrochloride + - Ontorpacept + - Ontuxizumab + - Onvansertib + - Onvatilimab + - Opaganib + - OPCs/Green Tea/Spirullina/Curcumin/Antrodia Camphorate/Fermented Soymilk Extract + Capsule + - Opioid Growth Factor + - Opolimogene Capmilisbac + - Oportuzumab Monatox + - Oprozomib + - Opucolimab + - Oral Aminolevulinic Acid Hydrochloride + - Oral Azacitidine + - Oral Cancer Vaccine V3-OVA + - Oral Docetaxel + - Oral Fludarabine Phosphate + - Oral Hsp90 Inhibitor IPI-493 + - Oral Ixabepilone + - Oral Microencapsulated Diindolylmethane + - Oral Milataxel + - Oral Myoma Vaccine V3-myoma + - Oral Pancreatic Cancer Vaccine V3-P + - Oral Picoplatin + - Oral Sodium Phenylbutyrate + - Oral Topotecan Hydrochloride + - Orantinib + - Oraxol + - Oregovomab + - Orelabrutinib + - Ormaplatin + - Ortataxel + - Orteronel + - Orvacabtagene Autoleucel + - Osilodrostat + - Osimertinib + - Otlertuzumab + - Ovapuldencel-T + - Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic + Cell Vaccine DC-006 + - Ovine Submaxillary Mucin + - OX40L-expressing Oncolytic Adenovirus DNX-2440 + - Oxaliplatin + - Oxaliplatin Eluting Beads + - Oxaliplatin-Encapsulated Transferrin-Conjugated N-glutaryl Phosphatidylethanolamine + Liposome + - Oxcarbazepine + - Oxeclosporin + - Oxidative Phosphorylation Inhibitor IACS-010759 + - Oxidative Phosphorylation Inhibitor IM156 + - Oxidopamine + - OxPhos Inhibitor VLX600 + - Ozarelix + - p38 MAPK Inhibitor LY3007113 + - p53 Peptide Vaccine MPS-128 + - p53-HDM2 Interaction Inhibitor MI-773 + - p53-HDM2 Protein-protein Interaction Inhibitor APG-115 + - p53/HDM2 Interaction Inhibitor CGM097 + - p70S6K Inhibitor LY2584702 + - p70S6K/Akt Inhibitor MSC2363318A + - p97 Inhibitor CB-5083 + - p97 Inhibitor CB-5339 + - p97 Inhibitor CB-5339 Tosylate + - p300/CBP Bromodomain Inhibitor CCS1477 + - P-cadherin Antagonist PF-03732010 + - P-cadherin Inhibitor PCA062 + - P-cadherin-targeting Agent PF-06671008 + - P-p68 Inhibitor RX-5902 + - P-TEFb Inhibitor BAY1143572 + - Paclitaxel + - Paclitaxel Ceribate + - Paclitaxel Injection Concentrate for Nanodispersion + - Paclitaxel Liposome + - Paclitaxel Poliglumex + - Paclitaxel Polymeric Micelle Formulation NANT-008 + - Paclitaxel PPE Microspheres + - Paclitaxel Trevatide + - Paclitaxel Vitamin E-Based Emulsion + - Paclitaxel-Loaded Polymeric Micelle + - Pacmilimab + - Pacritinib + - Padeliporfin + - Padoporfin + - PAK4 Inhibitor PF-03758309 + - PAK4/NAMPT Inhibitor KPT-9274 + - Palbociclib + - Palbociclib Isethionate + - Palifosfamide + - Palifosfamide Tromethamine + - Palladium Pd-103 + - Palonosetron Hydrochloride + - Pamidronate Disodium + - Pamidronic Acid + - Pamiparib + - Pamrevlumab + - pan FGFR Inhibitor PRN1371 + - Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514 + - Pan-AKT Inhibitor ARQ751 + - Pan-AKT Kinase Inhibitor GSK690693 + - Pan-FGFR Inhibitor LY2874455 + - Pan-FLT3/Pan-BTK Multi-kinase Inhibitor CG-806 + - pan-HER Kinase Inhibitor AC480 + - Pan-IDH Mutant Inhibitor AG-881 + - Pan-KRAS Inhibitor BI 1701963 + - Pan-Mutant-IDH1 Inhibitor Bay-1436032 + - Pan-mutation-selective EGFR Inhibitor CLN-081 + - pan-PI3K Inhibitor CLR457 + - pan-PI3K/mTOR Inhibitor SF1126 + - Pan-PIM Inhibitor INCB053914 + - pan-PIM Kinase Inhibitor AZD1208 + - pan-PIM Kinase Inhibitor NVP-LGB-321 + - pan-RAF Inhibitor LXH254 + - Pan-RAF Inhibitor LY3009120 + - pan-RAF Kinase Inhibitor CCT3833 + - pan-RAF Kinase Inhibitor TAK-580 + - Pan-RAR Agonist/AP-1 Inhibitor LGD 1550 + - Pan-TRK Inhibitor NOV1601 + - Pan-TRK Inhibitor ONO-7579 + - Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981 + - Pancratistatin + - Panitumumab + - Panobinostat + - Panobinostat Nanoparticle Formulation MTX110 + - Panulisib + - Paricalcitol + - PARP7 Inhibitor RBN-2397 + - PARP 1/2 Inhibitor IMP4297 + - PARP 1/2 Inhibitor NOV1401 + - PARP Inhibitor AZD2461 + - PARP Inhibitor CEP-9722 + - PARP Inhibitor E7016 + - PARP Inhibitor NMS-03305293 + - PARP-1/2 Inhibitor ABT-767 + - PARP/Tankyrase Inhibitor 2X-121 + - Parsaclisib + - Parsaclisib Hydrochloride + - Parsatuzumab + - Partially Engineered T-regulatory Cell Donor Graft TRGFT-201 + - Parvovirus H-1 + - Pasireotide + - Pasotuxizumab + - Patidegib + - Patidegib Topical Gel + - Patritumab + - Patritumab Deruxtecan + - Patupilone + - Paxalisib + - Pazopanib + - Pazopanib Hydrochloride + - pbi-shRNA STMN1 Lipoplex + - PBN Derivative OKN-007 + - PCNU + - PD-1 Directed Probody CX-188 + - PD-1 Inhibitor + - PD-L1 Inhibitor GS-4224 + - PD-L1 Inhibitor INCB086550 + - PD-L1/4-1BB/HSA Trispecific Fusion Protein NM21-1480 + - PD-L1/PD-L2/VISTA Antagonist CA-170 + - PDK1 Inhibitor AR-12 + - pDNA-encoding Emm55 Autologous Cancer Cell Vaccine IFx-Hu2.0 + - PE/HPV16 E7/KDEL Fusion Protein/GPI-0100 TVGV-1 + - PEG-interleukin-2 + - PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1 + - PEG-Proline-Interferon Alfa-2b + - Pegargiminase + - Pegaspargase + - Pegdinetanib + - Pegfilgrastim + - Pegilodecakin + - Peginterferon Alfa-2a + - Peginterferon Alfa-2b + - Pegvisomant + - Pegvorhyaluronidase Alfa + - Pegylated Deoxycytidine Analogue DFP-14927 + - Pegylated Interferon Alfa + - Pegylated Liposomal Belotecan + - Pegylated Liposomal Doxorubicin Hydrochloride + - Pegylated Liposomal Irinotecan + - Pegylated Liposomal Mitomycin C Lipid-based Prodrug + - Pegylated Liposomal Mitoxantrone Hydrochloride + - Pegylated Liposomal Nanoparticle-based Docetaxel Prodrug MNK-010 + - Pegylated Paclitaxel + - Pegylated Recombinant Human Arginase I BCT-100 + - Pegylated Recombinant Human Hyaluronidase PH20 + - Pegylated Recombinant Interleukin-2 THOR-707 + - Pegylated Recombinant L-asparaginase Erwinia chrysanthemi + - Pegylated SN-38 Conjugate PLX038 + - Pegzilarginase + - Pelabresib + - Pelareorep + - Peldesine + - Pelitinib + - Pelitrexol + - Pembrolizumab + - Pemetrexed + - Pemetrexed Disodium + - Pemigatinib + - Pemlimogene Merolisbac + - Penberol + - Penclomedine + - Penicillamine + - Pentamethylmelamine + - Pentamustine + - Pentostatin + - Pentoxifylline + - PEOX-based Polymer Encapsulated Paclitaxel FID-007 + - PEP-3-KLH Conjugate Vaccine + - Pepinemab + - Peplomycin + - Peplomycin Sulfate + - Peposertib + - Peptichemio + - Peptide 946 Melanoma Vaccine + - Peptide 946-Tetanus Peptide Conjugate Melanoma Vaccine + - Peretinoin + - Perflenapent Emulsion + - Perfosfamide + - Perifosine + - Perillyl Alcohol + - Personalized ALL-specific Multi-HLA-binding Peptide Vaccine + - Personalized and Adjusted Neoantigen Peptide Vaccine PANDA-VAC + - Personalized Cancer Vaccine RO7198457 + - Personalized Neoantigen DNA Vaccine GNOS-PV01 + - Personalized Neoantigen DNA Vaccine GNOS-PVO2 + - Personalized Neoantigen Peptide Vaccine iNeo-Vac-P01 + - Personalized Neoepitope Yeast Vaccine YE-NEO-001 + - Personalized Peptide Cancer Vaccine NEO-PV-01 + - Pertuzumab + - Pevonedistat + - Pexastimogene Devacirepvec + - Pexidartinib + - Pexmetinib + - PGG Beta-Glucan + - PGLA/PEG Copolymer-Based Paclitaxel + - PH20 Hyaluronidase-expressing Adenovirus VCN-01 + - Phaleria macrocarpa Extract DLBS-1425 + - Pharmacological Ascorbate + - Phellodendron amurense Bark Extract + - Phenesterin + - Phenethyl Isothiocyanate + - Phenethyl Isothiocyanate-containing Watercress Juice + - Phenyl Acetate + - Phenytoin Sodium + - Phosphaplatin PT-112 + - Phosphatidylcholine-Bound Silybin + - Phospholipid Ether-drug Conjugate CLR 131 + - Phosphoramide Mustard + - Phosphorodiamidate Morpholino Oligomer AVI-4126 + - Phosphorus P-32 + - Photodynamic Compound TLD-1433 + - Photosensitizer LUZ 11 + - Phytochlorin Sodium-Polyvinylpyrrolidone Complex + - PI3K Alpha/Beta Inhibitor BAY1082439 + - PI3K Alpha/mTOR Inhibitor PWT33597 Mesylate + - PI3K Inhibitor ACP-319 + - PI3K Inhibitor BGT226 + - PI3K Inhibitor GDC0077 + - PI3K Inhibitor GDC-0084 + - PI3K Inhibitor GSK1059615 + - PI3K Inhibitor WX-037 + - PI3K Inhibitor ZSTK474 + - PI3K p110beta/delta Inhibitor KA2237 + - PI3K-alpha Inhibitor MEN1611 + - PI3K-beta Inhibitor GSK2636771 + - PI3K-beta Inhibitor SAR260301 + - PI3K-delta Inhibitor AMG 319 + - PI3K-delta Inhibitor HMPL 689 + - PI3K-delta Inhibitor INCB050465 + - PI3K-delta Inhibitor PWT143 + - PI3K-delta Inhibitor SHC014748M + - PI3K-delta Inhibitor YY-20394 + - PI3K-gamma Inhibitor IPI-549 + - PI3K/BET Inhibitor LY294002 + - PI3K/mTOR Kinase Inhibitor DS-7423 + - PI3K/mTOR Kinase Inhibitor PF-04691502 + - PI3K/mTOR Kinase Inhibitor VS-5584 + - PI3K/mTOR Kinase Inhibitor WXFL10030390 + - PI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170 + - PI3K/mTORC1/mTORC2 Inhibitor DCBCI0901 + - PI3Ka/mTOR Inhibitor PKI-179 + - PI3Kalpha Inhibitor AZD8835 + - PI3Kbeta Inhibitor AZD8186 + - PI3Kdelta Inhibitor GS-9901 + - Pibenzimol + - Pibrozelesin + - Pibrozelesin Hydrobromide + - Picibanil + - Picoplatin + - Picrasinoside H + - Picropodophyllin + - Pictilisib + - Pictilisib Bismesylate + - Pidilizumab + - Pilaralisib + - PIM Kinase Inhibitor LGH447 + - PIM Kinase Inhibitor SGI-1776 + - PIM Kinase Inhibitor TP-3654 + - PIM/FLT3 Kinase Inhibitor SEL24 + - Pimasertib + - Pimitespib + - Pimurutamab + - Pinatuzumab Vedotin + - Pingyangmycin + - Pinometostat + - Pioglitazone + - Pioglitazone Hydrochloride + - Pipendoxifene + - Piperazinedione + - Piperine Extract (Standardized) + - Pipobroman + - Piposulfan + - Pirarubicin + - Pirarubicin Hydrochloride + - Pirfenidone + - Piritrexim + - Piritrexim Isethionate + - Pirotinib + - Piroxantrone + - Piroxantrone Hydrochloride + - Pixantrone + - Pixantrone Dimaleate + - Pixatimod + - PKA Regulatory Subunit RIalpha Mixed-Backbone Antisense Oligonucleotide GEM + 231 + - PKC-alpha Antisense Oligodeoxynucleotide ISIS 3521 + - PKC-beta Inhibitor MS-553 + - Placebo + - Pladienolide Derivative E7107 + - Plamotamab + - Plasmid DNA Vaccine pING-hHER3FL + - Platinum + - Platinum Acetylacetonate-Titanium Dioxide Nanoparticles + - Platinum Compound + - Plevitrexed + - Plicamycin + - Plinabulin + - Plitidepsin + - Plk1 Inhibitor BI 2536 + - PLK1 Inhibitor CYC140 + - PLK1 Inhibitor TAK-960 + - Plocabulin + - Plozalizumab + - pNGVL4a-CRT-E6E7L2 DNA Vaccine + - pNGVL4a-Sig/E7(detox)/HSP70 DNA and HPV16 L2/E6/E7 Fusion Protein TA-CIN Vaccine + PVX-2 + - Pol I Inhibitor CX5461 + - Polatuzumab Vedotin + - Polidocanol + - Poliglusam + - Polo-like Kinase 1 Inhibitor GSK461364 + - Polo-like Kinase 1 Inhibitor MK1496 + - Polo-like Kinase 1 Inhibitor NMS-1286937 + - Polo-like Kinase 4 Inhibitor CFI-400945 Fumarate + - Poly ICLC + - Poly-alendronate Dextran-Guanidine Conjugate + - Poly-gamma Glutamic Acid + - Polyamine Analog SL11093 + - Polyamine Analogue PG11047 + - Polyamine Analogue SBP-101 + - Polyamine Transport Inhibitor AMXT-1501 Dicaprate + - Polyandrol + - Polyethylene Glycol Recombinant Endostatin + - Polyethyleneglycol-7-ethyl-10-hydroxycamptothecin DFP-13318 + - Polymer-conjugated IL-15 Receptor Agonist NKTR-255 + - Polymer-encapsulated Luteolin Nanoparticle + - Polymeric Camptothecin Prodrug XMT-1001 + - Polypodium leucotomos Extract + - Polysaccharide-K + - Polysialic Acid + - Polyunsaturated Fatty Acid + - Polyvalent Melanoma Vaccine + - Pomalidomide + - Pomegranate Juice + - Pomegranate Liquid Extract + - Ponatinib + - Ponatinib Hydrochloride + - Porcupine Inhibitor CGX1321 + - Porcupine Inhibitor ETC-1922159 + - Porcupine Inhibitor RXC004 + - Porcupine Inhibitor WNT974 + - Porcupine Inhibitor XNW7201 + - Porfimer Sodium + - Porfiromycin + - Poziotinib + - PPAR Alpha Antagonist TPST-1120 + - PR1 Leukemia Peptide Vaccine + - Pracinostat + - Pralatrexate + - Pralsetinib + - Praluzatamab Ravtansine + - PRAME-targeting T-cell Receptor/Inducible Caspase 9 BPX-701 + - Pravastatin Sodium + - Prednimustine + - Prednisolone + - Prednisolone Acetate + - Prednisolone Sodium Phosphate + - Prednisone + - Prexasertib + - Prexigebersen + - PRIMA-1 Analog APR-246 + - Prime Cancer Vaccine MVA-BN-CV301 + - Prinomastat + - PRMT1 Inhibitor GSK3368715 + - PRMT5 Inhibitor JNJ-64619178 + - PRMT5 Inhibitor PRT811 + - Proapoptotic Sulindac Analog CP-461 + - Procarbazine + - Procarbazine Hydrochloride + - Procaspase Activating Compound-1 VO-100 + - Progestational IUD + - Prohibitin-Targeting Peptide 1 + - Prolgolimab + - Prostaglandin E2 EP4 Receptor Inhibitor AN0025 + - Prostaglandin E2 EP4 Receptor Inhibitor E7046 + - Prostate Cancer Vaccine ONY-P1 + - Prostate Health Cocktail Dietary Supplement + - Prostatic Acid Phosphatase-Sargramostim Fusion Protein PA2024 + - Protease-activated Anti-PD-L1 Antibody Prodrug CX-072 + - Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 + - Protein Arginine Methyltransferase 5 Inhibitor PF-06939999 + - Protein Arginine Methyltransferase 5 Inhibitor PRT543 + - Protein Kinase C Inhibitor IDE196 + - Protein Phosphatase 2A Inhibitor LB-100 + - Protein Stabilized Liposomal Docetaxel Nanoparticles + - Protein Tyrosine Kinase 2 Inhibitor IN10018 + - Proxalutamide + - PSA/IL-2/GM-CSF Vaccine + - PSA/PSMA DNA Plasmid INO-5150 + - Pseudoisocytidine + - PSMA-targeted Docetaxel Nanoparticles BIND-014 + - PSMA-targeted Tubulysin B-containing Conjugate EC1169 + - PSMA/CD3 Tri-specific T-cell Activating Construct HPN424 + - PTEF-b/CDK9 Inhibitor BAY1251152 + - Pterostilbene + - Pumitepa + - Puquitinib + - Puquitinib Mesylate + - Puromycin + - Puromycin Hydrochloride + - PV-10 + - PVA Microporous Hydrospheres/Doxorubicin Hydrochloride + - Pyrazinamide + - Pyrazoloacridine + - Pyridyl Cyanoguanidine CHS 828 + - Pyrotinib + - Pyrotinib Dimaleate + - Pyroxamide + - Pyruvate Kinase Inhibitor TLN-232 + - Pyruvate Kinase M2 Isoform Activator TP-1454 + - Qilisheng Immunoregulatory Oral Solution + - Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine + - Quarfloxin + - Quinacrine Hydrochloride + - Quinine + - Quisinostat + - Quizartinib + - R-(-)-Gossypol Acetic Acid + - Rabusertib + - Racemetyrosine/Methoxsalen/Phenytoin/Sirolimus SM-88 + - Racotumomab + - RAD51 Inhibitor CYT-0851 + - Radgocitabine + - Radgocitabine Hydrochloride + - Radioactive Iodine + - Radiolabeled CC49 + - Radium Ra 223 Dichloride + - Radium Ra 224-labeled Calcium Carbonate Microparticles + - Radix Angelicae Sinensis/Radix Astragali Herbal Supplement + - Radotinib Hydrochloride + - Raf Kinase Inhibitor HM95573 + - RAF Kinase Inhibitor L-779450 + - RAF Kinase Inhibitor XL281 + - Ragifilimab + - Ralaniten Acetate + - Ralimetinib Mesylate + - Raloxifene + - Raloxifene Hydrochloride + - Raltitrexed + - Ramucirumab + - Ranibizumab + - Ranimustine + - Ranolazine + - Ranpirnase + - RARalpha Agonist IRX5183 + - Ras Inhibitor + - Ras Peptide ASP + - Ras Peptide CYS + - Ras Peptide VAL + - Razoxane + - Realgar-Indigo naturalis Formulation + - Rebastinib Tosylate + - Rebeccamycin + - Rebimastat + - Receptor Tyrosine Kinase Inhibitor R1530 + - Recombinant Adenovirus-p53 SCH-58500 + - Recombinant Anti-WT1 Immunotherapeutic GSK2302024A + - Recombinant Bacterial Minicells VAX014 + - Recombinant Bispecific Single-Chain Antibody rM28 + - Recombinant CD40-Ligand + - Recombinant Erwinia asparaginase JZP-458 + - Recombinant Erythropoietin + - Recombinant Fas Ligand + - Recombinant Fractalkine + - Recombinant Granulocyte-Macrophage Colony-Stimulating Factor + - Recombinant Human 6Ckine + - Recombinant Human Adenovirus Type 5 H101 + - Recombinant Human Angiotensin Converting Enzyme 2 APN01 + - Recombinant Human Apolipoprotein(a) Kringle V MG1102 + - Recombinant Human EGF-rP64K/Montanide ISA 51 Vaccine + - Recombinant Human Endostatin + - Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine + - Recombinant Human Papillomavirus 11-valent Vaccine + - Recombinant Human Papillomavirus Bivalent Vaccine + - Recombinant Human Papillomavirus Nonavalent Vaccine + - Recombinant Human Plasminogen Kringle 5 Domain ABT 828 + - Recombinant Human TRAIL-Trimer Fusion Protein SCB-313 + - Recombinant Humanized Anti-HER-2 Bispecific Monoclonal Antibody MBS301 + - Recombinant Interferon + - Recombinant Interferon Alfa + - Recombinant Interferon Alfa-1b + - Recombinant Interferon Alfa-2a + - Recombinant Interferon Alfa-2b + - Recombinant Interferon Alpha 2b-like Protein + - Recombinant Interferon Beta + - Recombinant Interferon Gamma + - Recombinant Interleukin-2 + - Recombinant Interleukin-6 + - Recombinant Interleukin-12 + - Recombinant Interleukin-13 + - Recombinant Interleukin-18 + - Recombinant KSA Glycoprotein CO17-1A + - Recombinant Leukocyte Interleukin + - Recombinant Leukoregulin + - Recombinant Luteinizing Hormone + - Recombinant Macrophage Colony-Stimulating Factor + - Recombinant MAGE-3.1 Antigen + - Recombinant MIP1-alpha Variant ECI301 + - Recombinant Modified Vaccinia Ankara-5T4 Vaccine + - Recombinant Oncolytic Poliovirus PVS-RIPO + - Recombinant Platelet Factor 4 + - Recombinant PRAME Protein Plus AS15 Adjuvant GSK2302025A + - Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207 + - Recombinant Super-compound Interferon + - Recombinant Thyroglobulin + - Recombinant Thyrotropin Alfa + - Recombinant Transforming Growth Factor-Beta + - Recombinant Transforming Growth Factor-Beta-2 + - Recombinant Tumor Necrosis Factor-Alpha + - Recombinant Tyrosinase-Related Protein-2 + - Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and + Sodium-Iodide Symporter + - Redaporfin + - Refametinib + - Regorafenib + - Relacorilant + - Relatlimab + - Relugolix + - Remetinostat + - Renal Cell Carcinoma Peptides Vaccine IMA901 + - Reparixin + - Repotrectinib + - Resiquimod + - Resiquimod Topical Gel + - Resistant Starch + - Resminostat + - Resveratrol + - Resveratrol Formulation SRT501 + - RET Inhibitor DS-5010 + - RET Mutation/Fusion Inhibitor BLU-667 + - RET/SRC Inhibitor TPX-0046 + - Retaspimycin + - Retaspimycin Hydrochloride + - Retelliptine + - Retifanlimab + - Retinoic Acid Agent Ro 16-9100 + - Retinoid 9cUAB30 + - Retinol + - Retinyl Acetate + - Retinyl Palmitate + - Retrovector Encoding Mutant Anti-Cyclin G1 + - Revdofilimab + - Rexinoid NRX 194204 + - Rezivertinib + - RFT5-dgA Immunotoxin IMTOX25 + - Rhenium Re 188 BMEDA-labeled Liposomes + - Rhenium Re-186 Hydroxyethylidene Diphosphonate + - Rhenium Re-188 Ethiodized Oil + - Rhenium Re-188 Etidronate + - Rhizoxin + - RhoC Peptide Vaccine RV001V + - Ribociclib + - Ribociclib/Letrozole + - Ribonuclease QBI-139 + - Ribosome-Inactivating Protein CY503 + - Ribozyme RPI.4610 + - Rice Bran + - Ricolinostat + - Ridaforolimus + - Rigosertib + - Rigosertib Sodium + - Rilimogene Galvacirepvec + - Rilimogene Galvacirepvec/Rilimogene Glafolivec + - Rilimogene Glafolivec + - Rilotumumab + - Rindopepimut + - Ripertamab + - RIPK1 Inhibitor GSK3145095 + - Ripretinib + - Risperidone Formulation in Rumenic Acid + - Ritrosulfan + - Rituximab + - Rituximab and Hyaluronidase Human + - Rituximab Conjugate CON-4619 + - Rivaroxaban + - Riviciclib + - Rivoceranib + - Rivoceranib Mesylate + - RNR Inhibitor COH29 + - Robatumumab + - Roblitinib + - ROBO1-targeted BiCAR-NKT Cells + - Rocakinogene Sifuplasmid + - Rocapuldencel-T + - Rociletinib + - Rodorubicin + - Roducitabine + - Rofecoxib + - Roflumilast + - Rogaratinib + - Rogletimide + - Rolinsatamab Talirine + - Romidepsin + - Roneparstat + - Roniciclib + - Ropeginterferon Alfa-2B + - Ropidoxuridine + - Ropocamptide + - Roquinimex + - RORgamma Agonist LYC-55716 + - Rosabulin + - Rose Bengal Solution PV-10 + - Rosiglitazone Maleate + - Rosmantuzumab + - Rosopatamab + - Rosuvastatin + - Rovalpituzumab Tesirine + - RSK1-4 Inhibitor PMD-026 + - Rubitecan + - Rucaparib + - Rucaparib Camsylate + - Rucaparib Phosphate + - Ruthenium Ru-106 + - Ruthenium-based Small Molecule Therapeutic BOLD-100 + - Ruthenium-based Transferrin Targeting Agent NKP-1339 + - Ruxolitinib + - Ruxolitinib Phosphate + - Ruxotemitide + - S1P Receptor Agonist KRP203 + - S-Adenosylmethionine + - S-equol + - Sabarubicin + - Sabatolimab + - Sacituzumab Govitecan + - Sacubitril/Valsartan + - Safingol + - Sagopilone + - Salirasib + - Salmonella VNP20009 + - Sam68 Modulator CWP232291 + - Samalizumab + - Samarium Sm 153-DOTMP + - Samotolisib + - Samrotamab Vedotin + - Samuraciclib + - Sapacitabine + - Sapanisertib + - Sapitinib + - Saracatinib + - Saracatinib Difumarate + - SarCNU + - Sardomozide + - Sargramostim + - Sasanlimab + - Satraplatin + - Savolitinib + - SBIL-2 + - Scopoletin + - SDF-1 Receptor Antagonist PTX-9908 + - Seclidemstat + - Sedoxantrone Trihydrochloride + - Selatinib Ditosilate + - Selective Androgen Receptor Modulator RAD140 + - Selective Cytokine Inhibitory Drug CC-1088 + - Selective Estrogen Receptor Degrader AZD9496 + - Selective Estrogen Receptor Degrader AZD9833 + - Selective Estrogen Receptor Degrader LSZ102 + - Selective Estrogen Receptor Degrader LX-039 + - Selective Estrogen Receptor Degrader LY3484356 + - Selective Estrogen Receptor Degrader SRN-927 + - Selective Estrogen Receptor Modulator CC-8490 + - Selective Estrogen Receptor Modulator TAS-108 + - Selective Glucocorticoid Receptor Antagonist CORT125281 + - Selective Human Estrogen-receptor Alpha Partial Agonist TTC-352 + - Seliciclib + - Selicrelumab + - Selinexor + - Selitrectinib + - Selonsertib + - Selpercatinib + - Selumetinib + - Selumetinib Sulfate + - Semaxanib + - Semuloparin + - Semustine + - Seneca Valley Virus-001 + - Seocalcitol + - Sepantronium Bromide + - Serabelisib + - Serclutamab Talirine + - SERD D-0502 + - SERD G1T48 + - SERD GDC-9545 + - SERD SAR439859 + - SERD SHR9549 + - SERD ZN-c5 + - Serdemetan + - Sergiolide + - Seribantumab + - Serine/Threonine Kinase Inhibitor CBP501 + - Serine/Threonine Kinase Inhibitor XL418 + - Serplulimab + - Sevacizumab + - Seviteronel + - Shared Anti-Idiotype-AB-S006 + - Shared Anti-Idiotype-AB-S024A + - Shark Cartilage + - Shark Cartilage Extract AE-941 + - Shenqi Fuzheng Injection SQ001 + - Sho-Saiko-To + - Short Chain Fatty Acid HQK-1004 + - SHP2 Inhibitor JAB-3068 + - SHP2 Inhibitor RLY-1971 + - SHP2 Inhibitor RMC-4630 + - SHP2 Inhibitor TNO155 + - SHP-1 Agonist SC-43 + - Shu Yu Wan Formula + - Sialyl Tn Antigen + - Sialyl Tn-KLH Vaccine + - Sibrotuzumab + - siG12D LODER + - Silatecan AR-67 + - Silibinin + - Silicon Phthalocyanine 4 + - Silmitasertib Sodium + - Siltuximab + - Simalikalactone D + - Simeprevir + - Simlukafusp Alfa + - Simmitinib + - Simotaxel + - Simtuzumab + - Simurosertib + - Sintilimab + - Siplizumab + - Sipuleucel-T + - Siremadlin + - siRNA-transfected Peripheral Blood Mononuclear Cells APN401 + - Sirolimus + - SIRPa-4-1BBL Fusion Protein DSP107 + - SIRPa-Fc Fusion Protein TTI-621 + - SIRPa-Fc-CD40L Fusion Protein SL-172154 + - SIRPa-IgG4-Fc Fusion Protein TTI-622 + - Sitimagene Ceradenovec + - Sitravatinib + - Sivifene + - Sizofiran + - SLC6A8 Inhibitor RGX-202 + - SLCT Inhibitor GNS561 + - SMAC Mimetic BI 891065 + - Smac Mimetic GDC-0152 + - Smac Mimetic GDC-0917 + - Smac Mimetic LCL161 + - SMO Protein Inhibitor ZSP1602 + - Smoothened Antagonist BMS-833923 + - Smoothened Antagonist LDE225 Topical + - Smoothened Antagonist LEQ506 + - Smoothened Antagonist TAK-441 + - SN-38-Loaded Polymeric Micelles NK012 + - SNS01-T Nanoparticles + - Sobuzoxane + - Sodium Borocaptate + - Sodium Butyrate + - Sodium Dichloroacetate + - Sodium Iodide I-131 + - Sodium Metaarsenite + - Sodium Phenylbutyrate + - Sodium Salicylate + - Sodium Selenite + - Sodium Stibogluconate + - Sodium-Potassium Adenosine Triphosphatase Inhibitor RX108 + - Sofituzumab Vedotin + - Solitomab + - Sonepcizumab + - Sonidegib + - Sonolisib + - Sorafenib + - Sorafenib Tosylate + - Sorghum bicolor Supplement + - Sotigalimab + - Sotorasib + - Sotrastaurin + - Sotrastaurin Acetate + - Soy Isoflavones + - Soy Protein Isolate + - Spanlecortemlocel + - Sparfosate Sodium + - Sparfosic Acid + - Spartalizumab + - Spebrutinib + - Spherical Nucleic Acid Nanoparticle NU-0129 + - Spirogermanium + - Spiromustine + - Spiroplatin + - Splicing Inhibitor H3B-8800 + - Spongistatin + - Squalamine Lactate + - SR-BP1/HSI Inhibitor SR31747A + - SR-T100 Gel + - Src Kinase Inhibitor AP 23846 + - Src Kinase Inhibitor KX2-391 + - Src Kinase Inhibitor KX2-391 Ointment + - Src Kinase Inhibitor M475271 + - Src/Abl Kinase Inhibitor AZD0424 + - Src/tubulin Inhibitor KX02 + - SRPK1/ABCG2 Inhibitor SCO-101 + - ssRNA-based Immunomodulator CV8102 + - SSTR2-targeting Protein/DM1 Conjugate PEN-221 + - St. John's Wort + - Stallimycin + - Staphylococcal Enterotoxin A + - Staphylococcal Enterotoxin B + - STAT3 Inhibitor DSP-0337 + - STAT3 Inhibitor OPB-31121 + - STAT3 Inhibitor OPB-51602 + - STAT3 Inhibitor TTI-101 + - STAT3 Inhibitor WP1066 + - STAT Inhibitor OPB-111077 + - Staurosporine + - STING Agonist BMS-986301 + - STING Agonist GSK3745417 + - STING Agonist IMSA101 + - STING Agonist MK-1454 + - STING Agonist SB 11285 + - STING Agonist TAK-676 + - STING-activating Cyclic Dinucleotide Agonist MIW815 + - STING-expressing E. coli SYNB1891 + - Streptonigrin + - Streptozocin + - Strontium Chloride Sr-89 + - Submicron Particle Paclitaxel Sterile Suspension + - Sugemalimab + - Sulfatinib + - Sulforaphane + - Sulindac + - Sulofenur + - Sumoylation Inhibitor TAK-981 + - Sunitinib + - Sunitinib Malate + - Super Enhancer Inhibitor GZ17-6.02 + - Superagonist Interleukin-15:Interleukin-15 Receptor alphaSu/Fc Fusion Complex + ALT-803 + - Superoxide Dismutase Mimetic GC4711 + - Suramin + - Suramin Sodium + - Survivin Antigen + - Survivin Antigen Vaccine DPX-Survivac + - Survivin mRNA Antagonist EZN-3042 + - Survivin-expressing CVD908ssb-TXSVN Vaccine + - Sustained-release Lipid Inhaled Cisplatin + - Sustained-release Mitomycin C Hydrogel Formulation UGN-101 + - Sustained-release Mitomycin C Hydrogel Formulation UGN-102 + - Syk Inhibitor HMPL-523 + - Synchrotope TA2M Plasmid DNA Vaccine + - Synchrovax SEM Plasmid DNA Vaccine + - Synthetic Alkaloid PM00104 + - Synthetic Glioblastoma Mutated Tumor-specific Peptides Vaccine Therapy APVAC2 + - Synthetic Glioblastoma Tumor-associated Peptides Vaccine Therapy APVAC1 + - Synthetic hTERT DNA Vaccine INO-1400 + - Synthetic hTERT DNA Vaccine INO-1401 + - Synthetic Hypericin + - Synthetic Long E6 Peptide-Toll-like Receptor Ligand Conjugate Vaccine ISA201 + - Synthetic Long E6/E7 Peptides Vaccine HPV-01 + - Synthetic Long HPV16 E6/E7 Peptides Vaccine ISA101b + - Synthetic Plumbagin PCUR-101 + - T900607 + - Tabalumab + - Tabelecleucel + - Tacedinaline + - Tafasitamab + - Tagraxofusp-erzs + - Talabostat + - Talabostat Mesylate + - Talacotuzumab + - Talactoferrin Alfa + - Taladegib + - Talampanel + - Talaporfin Sodium + - Talazoparib + - Taletrectinib + - Talimogene Laherparepvec + - Tallimustine + - Talmapimod + - Talotrexin + - Talotrexin Ammonium + - Taltobulin + - TAM/c-Met Inhibitor RXDX-106 + - Tamibarotene + - Taminadenant + - Tamoxifen + - Tamoxifen Citrate + - Tamrintamab Pamozirine + - Tandutinib + - Tanespimycin + - Tanibirumab + - Tankyrase Inhibitor STP1002 + - Tanomastat + - Tapotoclax + - Tarenflurbil + - Tarextumab + - Tariquidar + - Tasadenoturev + - Taselisib + - Tasidotin + - Tasisulam + - Tasisulam Sodium + - Tasquinimod + - Taurolidine + - Tauromustine + - Taurultam + - Taurultam Analogue GP-2250 + - Tavokinogene Telseplasmid + - Tavolimab + - Taxane Analogue TPI 287 + - Taxane Compound + - Taxol Analogue SID 530 + - Tazarotene + - Tazemetostat + - Tebentafusp + - Teclistamab + - Tecogalan Sodium + - Tefinostat + - Tegafur + - Tegafur-gimeracil-oteracil Potassium + - Tegafur-Gimeracil-Oteracil Potassium-Leucovorin Calcium Oral Formulation + - Tegafur-Uracil + - Tegavivint + - Teglarinad + - Teglarinad Chloride + - Telaglenastat + - Telaglenastat Hydrochloride + - Telapristone + - Telapristone Acetate + - Telatinib Mesylate + - Telisotuzumab + - Telisotuzumab Vedotin + - Telomerase Inhibitor FJ5002 + - Telomerase-specific Type 5 Adenovirus OBP-301 + - Teloxantrone + - Teloxantrone Hydrochloride + - Telratolimod + - Temarotene + - Temoporfin + - Temozolomide + - Temsirolimus + - Tenalisib + - Tenifatecan + - Teniposide + - Tepoditamab + - Tepotinib + - Teprotumumab + - Terameprocol + - Terfluranol + - Tergenpumatucel-L + - Teroxirone + - Tertomotide + - Tesetaxel + - Tesevatinib + - Tesidolumab + - Testolactone + - Testosterone Enanthate + - Tetanus Toxoid Vaccine + - Tetradecanoylphorbol Acetate + - Tetrahydrouridine + - Tetraphenyl Chlorin Disulfonate + - Tetrathiomolybdate + - Tezacitabine + - Tezacitabine Anhydrous + - TGF-beta Receptor 1 Inhibitor PF-06952229 + - TGF-beta Receptor 1 Kinase Inhibitor SH3051 + - TGF-beta Receptor 1 Kinase Inhibitor YL-13027 + - TGFa-PE38 Immunotoxin + - TGFbeta Inhibitor LY3200882 + - TGFbeta Receptor Ectodomain-IgG Fc Fusion Protein AVID200 + - Thalicarpine + - Thalidomide + - Theliatinib + - Theramide + - Therapeutic Angiotensin-(1-7) + - Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907 + - Therapeutic Cancer Vaccine ATP128 + - Therapeutic Estradiol + - Therapeutic Hydrocortisone + - Therapeutic Liver Cancer Peptide Vaccine IMA970A + - Thiarabine + - Thiodiglycol + - Thioguanine + - Thioguanine Anhydrous + - Thioinosine + - Thioredoxin-1 Inhibitor PX-12 + - Thiotepa + - Thioureidobutyronitrile + - THL-P + - Thorium Th 227 Anetumab + - Thorium Th 227 Anetumab Corixetan + - Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439 + - Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497 + - Threonine Tyrosine Kinase Inhibitor CFI-402257 + - Thymidylate Synthase Inhibitor CX1106 + - Thymidylate Synthase Inhibitor DFP-11207 + - Thymopentin + - Thyroid Extract + - Tiazofurin + - Tidutamab + - Tigapotide + - Tigatuzumab + - TIGIT Inhibitor M6223 + - TIGIT-targeting Agent MK-7684 + - Tilarginine + - Tilogotamab + - Tilsotolimod Sodium + - Timonacic + - Tin Ethyl Etiopurpurin + - Tinostamustine + - Tinzaparin Sodium + - Tiomolibdate Choline + - Tiomolibdate Diammonium + - Tipapkinogene Sovacivec + - Tipifarnib + - Tipiracil + - Tipiracil Hydrochloride + - Tirabrutinib + - Tiragolumab + - Tirapazamine + - Tirbanibulin + - Tisagenlecleucel + - Tislelizumab + - Tisotumab Vedotin + - Tivantinib + - Tivozanib + - TLC ELL-12 + - TLR7 Agonist 852A + - TLR7 agonist BNT411 + - TLR7 Agonist LHC165 + - TLR7/8/9 Antagonist IMO-8400 + - TLR8 Agonist DN1508052 + - TLR9 Agonist AST-008 + - TLR9 Agonist SD-101 + - TLR Agonist BDB001 + - TLR Agonist BSG-001 + - TLR Agonist CADI-05 + - TLR-Directed Cationic Lipid-DNA Complex JVRS-100 + - TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells + - Tocilizumab + - Tocladesine + - Tocotrienol + - Tocotrienol-rich Fraction + - Tolebrutinib + - Toll-like Receptor 7 Agonist DSP-0509 + - Tolnidamine + - Tomaralimab + - Tomato-Soy Juice + - Tomivosertib + - Topical Betulinic Acid + - Topical Celecoxib + - Topical Fluorouracil + - Topical Gemcitabine Hydrochloride + - Topical Potassium Dobesilate + - Topical Trichloroacetic Acid + - Topixantrone + - Topoisomerase I Inhibitor Genz-644282 + - Topoisomerase I Inhibitor LMP400 + - Topoisomerase I Inhibitor LMP776 + - Topoisomerase I/II Inhibitor NEV-801 + - Topoisomerase-1 Inhibitor LMP744 + - Topoisomerase-II Inhibitor Racemic XK469 + - Topoisomerase-II-beta Inhibitor Racemic XK469 + - Topotecan + - Topotecan Hydrochloride + - Topotecan Hydrochloride Liposomes + - Topotecan Sustained-release Episcleral Plaque + - Topsalysin + - TORC1/2 Kinase Inhibitor DS-3078a + - Toremifene + - Toremifene Citrate + - Toripalimab + - Tosedostat + - Tositumomab + - Total Androgen Blockade + - Tovetumab + - Tozasertib Lactate + - TP40 Immunotoxin + - Trabectedin + - Trabedersen + - TRAIL Receptor Agonist ABBV-621 + - Trametinib + - Trametinib Dimethyl Sulfoxide + - Trans Sodium Crocetinate + - Transdermal 4-Hydroxytestosterone + - Transdermal 17beta-Estradiol Gel BHR-200 + - Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01 + - Transferrin Receptor-Targeted Liposomal p53 cDNA + - Transferrin-CRM107 + - Tranylcypromine Sulfate + - Trapoxin + - Trastuzumab + - Trastuzumab Conjugate BI-CON-02 + - Trastuzumab Deruxtecan + - Trastuzumab Duocarmazine + - Trastuzumab Emtansine + - Trastuzumab Monomethyl Auristatin F + - Trastuzumab-TLR 7/8 Agonist BDC-1001 + - Trastuzumab/Hyaluronidase-oysk + - Trastuzumab/Tesirine Antibody-drug Conjugate ADCT-502 + - Trebananib + - Tremelimumab + - Treosulfan + - Tretazicar + - Tretinoin + - Tretinoin Liposome + - Triamcinolone Acetonide + - Triamcinolone Hexacetonide + - Triapine + - Triazene Derivative CB10-277 + - Triazene Derivative TriN2755 + - Triazinate + - Triaziquone + - Tributyrin + - Triciribine Phosphate + - Trientine Hydrochloride + - Triethylenemelamine + - Trifluridine + - Trifluridine and Tipiracil Hydrochloride + - Trigriluzole + - Trilaciclib + - Trimelamol + - Trimeric GITRL-Fc OMP-336B11 + - Trimethylcolchicinic Acid + - Trimetrexate + - Trimetrexate Glucuronate + - Trioxifene + - Triplatin Tetranitrate + - Triptolide Analog + - Triptorelin + - Triptorelin Pamoate + - Tris-acryl Gelatin Microspheres + - Tritylcysteine + - TRK Inhibitor AZD6918 + - TRK Inhibitor TQB3558 + - TrkA Inhibitor VMD-928 + - Trodusquemine + - Trofosfamide + - Troglitazone + - Tropomyosin Receptor Kinase Inhibitor AZD7451 + - Troriluzole + - Troxacitabine + - Troxacitabine Nucleotide Prodrug MIV-818 + - TRPM8 Agonist D-3263 + - TRPV6 Calcium Channel Inhibitor SOR-C13 + - TSP-1 Mimetic ABT-510 + - TSP-1 Mimetic Fusion Protein CVX-045 + - Tubercidin + - Tubulin Binding Agent TTI-237 + - Tubulin Inhibitor ALB 109564 Dihydrochloride + - Tubulin Inhibitor ALB-109564 + - Tubulin Polymerization Inhibitor AEZS 112 + - Tubulin Polymerization Inhibitor CKD-516 + - Tubulin Polymerization Inhibitor VERU-111 + - Tubulin-Binding Agent SSR97225 + - Tucatinib + - Tucidinostat + - Tucotuzumab Celmoleukin + - Tyroserleutide + - Tyrosinase Peptide + - Tyrosinase-KLH + - Tyrosinase:146-156 Peptide + - Tyrosine Kinase Inhibitor + - Tyrosine Kinase Inhibitor OSI-930 + - Tyrosine Kinase Inhibitor SU5402 + - Tyrosine Kinase Inhibitor TL-895 + - Tyrosine Kinase Inhibitor XL228 + - UAE Inhibitor TAK-243 + - Ubenimex + - Ubidecarenone Nanodispersion BPM31510n + - Ublituximab + - Ulinastatin + - Ulixertinib + - Ulocuplumab + - Umbralisib + - Uncaria tomentosa Extract + - Upamostat + - Upifitamab + - Uproleselan + - Uprosertib + - Urabrelimab + - Uracil Ointment + - Urelumab + - Uroacitides + - Urokinase-Derived Peptide A6 + - Ursolic Acid + - USP14/UCHL5 Inhibitor VLX1570 + - Utomilumab + - Uzansertib + - V930 Vaccine + - Vaccine-Sensitized Draining Lymph Node Cells + - Vaccinium myrtillus/Macleaya cordata/Echinacea angustifolia Extract Granules + - Vactosertib + - Vadacabtagene Leraleucel + - Vadastuximab Talirine + - Vadimezan + - Valecobulin + - Valemetostat + - Valproic Acid + - Valrubicin + - Valspodar + - Vandetanib + - Vandetanib-eluting Radiopaque Bead BTG-002814 + - Vandortuzumab Vedotin + - Vantictumab + - Vanucizumab + - Vapreotide + - Varlilumab + - Varlitinib + - Varlitinib Tosylate + - Vascular Disrupting Agent BNC105 + - Vascular Disrupting Agent BNC105P + - Vascular Disrupting Agent ZD6126 + - Vatalanib + - Vatalanib Succinate + - Vecabrutinib + - Vector-peptide Conjugated Paclitaxel + - Vedolizumab + - VEGF Inhibitor PTC299 + - VEGF/HGF-targeting DARPin MP0250 + - VEGFR2 Tyrosine Kinase Inhibitor PF-00337210 + - VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813 + - VEGFR Inhibitor KRN951 + - VEGFR-2 DNA Vaccine VXM01 + - VEGFR/FGFR Inhibitor ODM-203 + - VEGFR/PDGFR Tyrosine Kinase Inhibitor TAK-593 + - Veliparib + - Veltuzumab + - Vemurafenib + - Venetoclax + - Verapamil + - Verpasep Caltespen + - Verubulin + - Verubulin Hydrochloride + - Vesencumab + - Vesigenurtucel-L + - VGEF Mixed-Backbone Antisense Oligonucleotide GEM 220 + - VGEFR/c-kit/PDGFR Tyrosine Kinase Inhibitor XL820 + - Viagenpumatucel-L + - Vibecotamab + - Vibostolimab + - Vilaprisan + - Vinblastine + - Vinblastine Sulfate + - Vincristine + - Vincristine Liposomal + - Vincristine Sulfate + - Vincristine Sulfate Liposome + - Vindesine + - Vinepidine + - Vinflunine + - Vinflunine Ditartrate + - Vinfosiltine + - Vinorelbine + - Vinorelbine Tartrate + - Vinorelbine Tartrate Emulsion + - Vinorelbine Tartrate Oral + - Vintafolide + - Vinzolidine + - Vinzolidine Sulfate + - Virulizin + - Vismodegib + - Vistusertib + - Vitamin D3 Analogue ILX23-7553 + - Vitamin E Compound + - Vitespen + - VLP-encapsulated TLR9 Agonist CMP-001 + - Vocimagene Amiretrorepvec + - Vofatamab + - Volasertib + - Volociximab + - Vonlerolizumab + - Vopratelimab + - Vorasidenib + - Vorinostat + - Vorolanib + - Vorsetzumab Mafodotin + - Vosaroxin + - Vosilasarm + - Voxtalisib + - Vulinacimab + - Warfarin Sodium + - Wee1 Inhibitor ZN-c3 + - Wee1 Kinase Inhibitor Debio 0123 + - White Carrot + - Wnt Signaling Inhibitor SM04755 + - Wnt Signaling Pathway Inhibitor SM08502 + - Wnt-5a Mimic Hexapeptide Foxy-5 + - Wobe-Mugos E + - WT1 Peptide Vaccine OCV-501 + - WT1 Peptide Vaccine WT2725 + - WT1 Protein-derived Peptide Vaccine DSP-7888 + - WT1-A10/AS01B Immunotherapeutic GSK2130579A + - WT1/PSMA/hTERT-encoding Plasmid DNA INO-5401 + - Xanthohumol + - XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410 + - Xeloda + - Xentuzumab + - Xevinapant + - Xiaoai Jiedu Decoction + - XIAP Antisense Oligonucleotide AEG35156 + - XIAP/cIAP1 Antagonist ASTX660 + - Xiliertinib + - Xisomab 3G3 + - XPO1 Inhibitor SL-801 + - Y 90 Monoclonal Antibody CC49 + - Y 90 Monoclonal Antibody HMFG1 + - Y 90 Monoclonal Antibody Lym-1 + - Y 90 Monoclonal Antibody m170 + - Y 90 Monoclonal Antibody M195 + - Yang Yin Fu Zheng + - Yangzheng Xiaoji Extract + - Yiqi-yangyin-jiedu Herbal Decoction + - Yttrium Y 90 Anti-CD19 Monoclonal Antibody BU12 + - Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12 + - Yttrium Y 90 Anti-CD45 Monoclonal Antibody BC8 + - Yttrium Y 90 Anti-CDH3 Monoclonal Antibody FF-21101 + - Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66 + - Yttrium Y 90 Basiliximab + - Yttrium Y 90 Colloid + - Yttrium Y 90 Daclizumab + - Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody M5A + - Yttrium Y 90 Glass Microspheres + - Yttrium Y 90 Monoclonal Antibody B3 + - Yttrium Y 90 Monoclonal Antibody BrE-3 + - Yttrium Y 90 Monoclonal Antibody Hu3S193 + - Yttrium Y 90 Monoclonal Antibody MN-14 + - Yttrium Y 90 Resin Microspheres + - Yttrium Y 90 Tabituximab Barzuxetan + - Yttrium Y 90-DOTA-Biotin + - Yttrium Y 90-DOTA-di-HSG Peptide IMP-288 + - Yttrium Y 90-Edotreotide + - Yttrium Y 90-labeled Anti-FZD10 Monoclonal Antibody OTSA101 + - Yttrium Y-90 Clivatuzumab Tetraxetan + - Yttrium Y-90 Epratuzumab Tetraxetan + - Yttrium Y-90 Ibritumomab Tiuxetan + - Yttrium Y-90 Tacatuzumab Tetraxetan + - Yttrium-90 Polycarbonate Brachytherapy Plaque + - Z-Endoxifen Hydrochloride + - Zalcitabine + - Zalifrelimab + - Zalutumumab + - Zandelisib + - Zanidatamab + - Zanolimumab + - Zanubrutinib + - Zebularine + - Zelavespib + - Zibotentan + - Zinc Finger Nuclease ZFN-603 + - Zinc Finger Nuclease ZFN-758 + - Zinostatin + - Zinostatin Stimalamer + - Zirconium Zr 89 Panitumumab + - Ziv-Aflibercept + - Zolbetuximab + - Zoledronic Acid + - Zoptarelin Doxorubicin + - Zorifertinib + - Zorubicin + - Zorubicin Hydrochloride + - Zotatifin + - Zotiraciclib Citrate + - Zuclomiphene Citrate + - Other + - Unknown + - Not Reported + enumDef: + 3'-dA Phosphoramidate NUC-7738: + $ref: + - "_terms_enum.yaml#/3da_phosphoramidate_nuc7738/common" + A2A Receptor Antagonist EOS100850: + $ref: + - "_terms_enum.yaml#/a2a_receptor_antagonist_eos100850/common" + Adenosine A2A Receptor Antagonist CS3005: + $ref: + - "_terms_enum.yaml#/adenosine_a2a_receptor_antagonist_cs3005/common" + Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE: + $ref: + - "_terms_enum.yaml#/adenovirus_5f35human_guanylyl_cyclase_cpadre/common" + Adenovirus Serotype 26-expressing HPV16 Vaccine JNJ-63682918: + $ref: + - "_terms_enum.yaml#/adenovirus_serotype_26expressing_hpv16_vaccine_jnj63682918/common" + Adenovirus Serotype 26-expressing HPV18 Vaccine JNJ-63682931: + $ref: + - "_terms_enum.yaml#/adenovirus_serotype_26expressing_hpv18_vaccine_jnj63682931/common" + ALK Inhibitor TAE684: + $ref: + - "_terms_enum.yaml#/alk_inhibitor_tae684/common" + ALK/ROS1/Met Inhibitor TQ-B3101: + $ref: + - "_terms_enum.yaml#/alkros1met_inhibitor_tqb3101/common" + Allogeneic Anti-BCMA CAR-transduced T-cells ALLO-715: + $ref: + - "_terms_enum.yaml#/allogeneic_antibcma_cartransduced_tcells_allo715/common" + Allogeneic Anti-BCMA-CAR T-cells PBCAR269A: + $ref: + - "_terms_enum.yaml#/allogeneic_antibcmacar_tcells_pbcar269a/common" + Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells: + $ref: + - "_terms_enum.yaml#/allogeneic_antibcmacs1_bispecific_cart_cells/common" + Allogeneic Anti-CD19 CAR T-cells ALLO-501A: + $ref: + - "_terms_enum.yaml#/allogeneic_anticd19_car_tcells_allo501a/common" + Allogeneic Anti-CD19 Universal CAR-T Cells CTA101: + $ref: + - "_terms_enum.yaml#/allogeneic_anticd19_universal_cart_cells_cta101/common" + Allogeneic Anti-CD20 CAR T-cells LUCAR-20S: + $ref: + - "_terms_enum.yaml#/allogeneic_anticd20_car_tcells_lucar20s/common" + Allogeneic Anti-CD20-CAR T-cells PBCAR20A: + $ref: + - "_terms_enum.yaml#/allogeneic_anticd20car_tcells_pbcar20a/common" + Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001: + $ref: + - "_terms_enum.yaml#/allogeneic_cd8_leukemiaassociated_antigens_specific_t_cells_nexi001/common" + Allogeneic CD22-specific Universal CAR-expressing T-lymphocytes UCART22: + $ref: + - "_terms_enum.yaml#/allogeneic_cd22specific_universal_carexpressing_tlymphocytes_ucart22/common" + Allogeneic CD56-positive CD3-negative Natural Killer Cells CYNK-001: + $ref: + - "_terms_enum.yaml#/allogeneic_cd56positive_cd3negative_natural_killer_cells_cynk001/common" + Allogeneic CRISPR-Cas9 Engineered Anti-BCMA T Cells CTX120: + $ref: + - "_terms_enum.yaml#/allogeneic_crisprcas9_engineered_antibcma_t_cells_ctx120/common" + Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130: + $ref: + - "_terms_enum.yaml#/allogeneic_crisprcas9_engineered_anticd70_cart_cells_ctx130/common" + Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A: + $ref: + - "_terms_enum.yaml#/allogeneic_cs1specific_universal_carexpressing_tlymphocytes_ucartcs1a/common" + Allogeneic Plasmacytoid Dendritic Cells Expressing Lung Tumor Antigens PDC*lung01: + $ref: + - "_terms_enum.yaml#/allogeneic_plasmacytoid_dendritic_cells_expressing_lung_tumor_antigens_pdclung01/common" + Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T-cells CTL 19: + $ref: + - "_terms_enum.yaml#/allogeneic_thirdparty_suicide_genetransduced_antihladpb10401_cd4_tcells_ctl_19/common" + Allosteric ErbB Inhibitor BDTX-189: + $ref: + - "_terms_enum.yaml#/allosteric_erbb_inhibitor_bdtx189/common" + Alobresib: + $ref: + - "_terms_enum.yaml#/alobresib/common" + Alofanib: + $ref: + - "_terms_enum.yaml#/alofanib/common" + Alpha V Beta 8 Antagonist PF-06940434: + $ref: + - "_terms_enum.yaml#/alpha_v_beta_8_antagonist_pf06940434/common" + Alsevalimab: + $ref: + - "_terms_enum.yaml#/alsevalimab/common" + Amivantamab: + $ref: + - "_terms_enum.yaml#/amivantamab/common" + Andecaliximab: + $ref: + - "_terms_enum.yaml#/andecaliximab/common" + Androgen Receptor Degrader CC-94676: + $ref: + - "_terms_enum.yaml#/androgen_receptor_degrader_cc94676/common" + Androgen Receptor Inhibitor EPI-7386: + $ref: + - "_terms_enum.yaml#/androgen_receptor_inhibitor_epi7386/common" + Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10: + $ref: + - "_terms_enum.yaml#/androgen_receptorglucocorticoid_receptor__antagonist_cb0310/common" + Anhydrous Enol-oxaloacetate: + $ref: + - "_terms_enum.yaml#/anhydrous_enoloxaloacetate/common" + Anti-5T4 Antibody-drug Conjugate ASN004: + $ref: + - "_terms_enum.yaml#/anti5t4_antibodydrug_conjugate_asn004/common" + Anti-5T4 Antibody-drug Conjugate SYD1875: + $ref: + - "_terms_enum.yaml#/anti5t4_antibodydrug_conjugate_syd1875/common" + Anti-B7-H3/DXd Antibody-drug Conjugate DS-7300a: + $ref: + - "_terms_enum.yaml#/antib7h3dxd_antibodydrug_conjugate_ds7300a/common" + Anti-BCMA Antibody-drug Conjugate CC-99712: + $ref: + - "_terms_enum.yaml#/antibcma_antibodydrug_conjugate_cc99712/common" + Anti-BCMA SparX Protein Plus BCMA-directed Anti-TAAG ARC T-cells CART-ddBCMA: + $ref: + - "_terms_enum.yaml#/antibcma_sparx_protein_plus_bcmadirected_antitaag_arc_tcells_cartddbcma/common" + Anti-BCMA/Anti-CD3 Bispecific Antibody REGN5459: + $ref: + - "_terms_enum.yaml#/antibcmaanticd3_bispecific_antibody_regn5459/common" + Anti-BTLA Monoclonal Antibody TAB004: + $ref: + - "_terms_enum.yaml#/antibtla_monoclonal_antibody_tab004/common" + Anti-BTN3A Agonistic Monoclonal Antibody ICT01: + $ref: + - "_terms_enum.yaml#/antibtn3a_agonistic_monoclonal_antibody_ict01/common" + Anti-c-Met Monoclonal Antibody HLX55: + $ref: + - "_terms_enum.yaml#/anticmet_monoclonal_antibody_hlx55/common" + Anti-CCR7 Antibody-drug Conjugate JBH492: + $ref: + - "_terms_enum.yaml#/anticcr7_antibodydrug_conjugate_jbh492/common" + Anti-CD3/Anti-5T4 Bispecific Antibody GEN1044: + $ref: + - "_terms_enum.yaml#/anticd3anti5t4_bispecific_antibody_gen1044/common" + Anti-CD3/Anti-GUCY2C Bispecific Antibody PF-07062119: + $ref: + - "_terms_enum.yaml#/anticd3antigucy2c_bispecific_antibody_pf07062119/common" + Anti-CD3/CD7-Ricin Toxin A Immunotoxin: + $ref: + - "_terms_enum.yaml#/anticd3cd7ricin_toxin_a_immunotoxin/common" + Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003: + $ref: + - "_terms_enum.yaml#/anticd19_antibodytcell_receptorexpressing_tcells_et019003/common" + Anti-CD19 iCAR NK Cells: + $ref: + - "_terms_enum.yaml#/anticd19_icar_nk_cells/common" + Anti-CD19/CD22 CAR NK Cells: + $ref: + - "_terms_enum.yaml#/anticd19cd22_car_nk_cells/common" + Anti-CD20 Monoclonal Antibody BAT4306F: + $ref: + - "_terms_enum.yaml#/anticd20_monoclonal_antibody_bat4306f/common" + Anti-CD20 Monoclonal Antibody MIL62: + $ref: + - "_terms_enum.yaml#/anticd20_monoclonal_antibody_mil62/common" + Anti-CD25 Monoclonal Antibody RO7296682: + $ref: + - "_terms_enum.yaml#/anticd25_monoclonal_antibody_ro7296682/common" + Anti-CD27 Agonistic Monoclonal Antibody MK-5890: + $ref: + - "_terms_enum.yaml#/anticd27_agonistic_monoclonal_antibody_mk5890/common" + Anti-CD30/DM1 Antibody-drug Conjugate F0002: + $ref: + - "_terms_enum.yaml#/anticd30dm1_antibodydrug_conjugate_f0002/common" + Anti-CD37 Bispecific Monoclonal Antibody GEN3009: + $ref: + - "_terms_enum.yaml#/anticd37_bispecific_monoclonal_antibody_gen3009/common" + Anti-CD38 Antibody-drug Conjugate STI-6129: + $ref: + - "_terms_enum.yaml#/anticd38_antibodydrug_conjugate_sti6129/common" + Anti-CD38 Monoclonal Antibody SAR442085: + $ref: + - "_terms_enum.yaml#/anticd38_monoclonal_antibody_sar442085/common" + Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257: + $ref: + - "_terms_enum.yaml#/anticd38cd28xcd3_trispecific_monoclonal_antibody_sar442257/common" + Anti-CD39 Monoclonal Antibody SRF617: + $ref: + - "_terms_enum.yaml#/anticd39_monoclonal_antibody_srf617/common" + Anti-CD40/Anti-4-1BB Bispecific Agonist Monoclonal Antibody GEN1042: + $ref: + - "_terms_enum.yaml#/anticd40anti41bb_bispecific_agonist_monoclonal_antibody_gen1042/common" + Anti-CD47 ADC SGN-CD47M: + $ref: + - "_terms_enum.yaml#/anticd47_adc_sgncd47m/common" + Anti-CD47 Monoclonal Antibody IMC-002: + $ref: + - "_terms_enum.yaml#/anticd47_monoclonal_antibody_imc002/common" + Anti-CD47/CD19 Bispecific Monoclonal Antibody TG-1801: + $ref: + - "_terms_enum.yaml#/anticd47cd19_bispecific_monoclonal_antibody_tg1801/common" + Anti-CD117 Monoclonal Antibody JSP191: + $ref: + - "_terms_enum.yaml#/anticd117_monoclonal_antibody_jsp191/common" + Anti-CD137 Agonistic Monoclonal Antibody AGEN2373: + $ref: + - "_terms_enum.yaml#/anticd137_agonistic_monoclonal_antibody_agen2373/common" + Anti-CD137 Agonistic Monoclonal Antibody ATOR-1017: + $ref: + - "_terms_enum.yaml#/anticd137_agonistic_monoclonal_antibody_ator1017/common" + Anti-CD137 Agonistic Monoclonal Antibody LVGN6051: + $ref: + - "_terms_enum.yaml#/anticd137_agonistic_monoclonal_antibody_lvgn6051/common" + Anti-CD205 Antibody-drug Conjugate OBT076: + $ref: + - "_terms_enum.yaml#/anticd205_antibodydrug_conjugate_obt076/common" + Anti-CD228/MMAE Antibody-drug Conjugate SGN-CD228A: + $ref: + - "_terms_enum.yaml#/anticd228mmae_antibodydrug_conjugate_sgncd228a/common" + Anti-claudin18.2 Monoclonal Antibody AB011: + $ref: + - "_terms_enum.yaml#/anticlaudin182_monoclonal_antibody_ab011/common" + Anti-Claudin18.2 Monoclonal Antibody TST001: + $ref: + - "_terms_enum.yaml#/anticlaudin182_monoclonal_antibody_tst001/common" + Anti-CTLA4 Antibody Fc Fusion Protein KN044: + $ref: + - "_terms_enum.yaml#/antictla4_antibody_fc_fusion_protein_kn044/common" + Anti-CTLA-4 Monoclonal Antibody ADG116: + $ref: + - "_terms_enum.yaml#/antictla4_monoclonal_antibody_adg116/common" + Anti-CTLA-4 Monoclonal Antibody HBM4003: + $ref: + - "_terms_enum.yaml#/antictla4_monoclonal_antibody_hbm4003/common" + Anti-CTLA-4 Monoclonal Antibody ONC-392: + $ref: + - "_terms_enum.yaml#/antictla4_monoclonal_antibody_onc392/common" + Anti-CTLA-4 Probody BMS-986288: + $ref: + - "_terms_enum.yaml#/antictla4_probody_bms986288/common" + Anti-CTLA-4/Anti-PD-1 Monoclonal Antibody Combination BCD-217: + $ref: + - "_terms_enum.yaml#/antictla4antipd1_monoclonal_antibody_combination_bcd217/common" + Anti-EGFR/CD16A Bispecific Antibody AFM24: + $ref: + - "_terms_enum.yaml#/antiegfrcd16a_bispecific_antibody_afm24/common" + Anti-FRA/Eribulin Antibody-drug Conjugate MORAb-202: + $ref: + - "_terms_enum.yaml#/antifraeribulin_antibodydrug_conjugate_morab202/common" + Anti-GARP Monoclonal Antibody ABBV-151: + $ref: + - "_terms_enum.yaml#/antigarp_monoclonal_antibody_abbv151/common" + Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999: + $ref: + - "_terms_enum.yaml#/antiglobo_hmmae_antibodydrug_conjugate_obi_999/common" + Anti-GPR20/DXd Antibody-drug Conjugate DS-6157a: + $ref: + - "_terms_enum.yaml#/antigpr20dxd_antibodydrug_conjugate_ds6157a/common" + Anti-gremlin-1 Monoclonal Antibody UCB6114: + $ref: + - "_terms_enum.yaml#/antigremlin1_monoclonal_antibody_ucb6114/common" + Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702: + $ref: + - "_terms_enum.yaml#/antiher2_antibody_conjugated_natural_killer_cells_ace1702/common" + Anti-HER2 Antibody-drug Conjugate BAT8001: + $ref: + - "_terms_enum.yaml#/antiher2_antibodydrug_conjugate_bat8001/common" + Anti-HER2 Antibody-drug Conjugate DP303c: + $ref: + - "_terms_enum.yaml#/antiher2_antibodydrug_conjugate_dp303c/common" + Anti-HER2 Monoclonal Antibody B002: + $ref: + - "_terms_enum.yaml#/antiher2_monoclonal_antibody_b002/common" + Anti-HER2 Monoclonal Antibody HLX22: + $ref: + - "_terms_enum.yaml#/antiher2_monoclonal_antibody_hlx22/common" + Anti-HER2-DM1 ADC B003: + $ref: + - "_terms_enum.yaml#/antiher2dm1_adc_b003/common" + Anti-HER2-DM1 Antibody-drug Conjugate GQ1001: + $ref: + - "_terms_enum.yaml#/antiher2dm1_antibodydrug_conjugate_gq1001/common" + Anti-HER2/MMAE Antibody-drug Conjugate MRG002: + $ref: + - "_terms_enum.yaml#/antiher2mmae_antibodydrug_conjugate_mrg002/common" + Anti-HLA-G Antibody TTX-080: + $ref: + - "_terms_enum.yaml#/antihlag_antibody_ttx080/common" + Anti-IL-8 Monoclonal Antibody BMS-986253: + $ref: + - "_terms_enum.yaml#/antiil8_monoclonal_antibody_bms986253/common" + Anti-integrin Beta-6/MMAE Antibody-drug Conjugate SGN-B6A: + $ref: + - "_terms_enum.yaml#/antiintegrin_beta6mmae_antibodydrug_conjugate_sgnb6a/common" + Anti-IRF4 Antisense Oligonucleotide ION251: + $ref: + - "_terms_enum.yaml#/antiirf4_antisense_oligonucleotide_ion251/common" + Anti-LAG-3 Monoclonal Antibody IBI-110: + $ref: + - "_terms_enum.yaml#/antilag3_monoclonal_antibody_ibi110/common" + Anti-latent TGF-beta 1 Monoclonal Antibody SRK-181: + $ref: + - "_terms_enum.yaml#/antilatent_tgfbeta_1_monoclonal_antibody_srk181/common" + Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102: + $ref: + - "_terms_enum.yaml#/antilewis_blewis_y_monoclonal_antibody_gnx102/common" + Anti-LILRB4 Monoclonal Antibody IO-202: + $ref: + - "_terms_enum.yaml#/antililrb4_monoclonal_antibody_io202/common" + Anti-mesothelin/MMAE Antibody-drug Conjugate RC88: + $ref: + - "_terms_enum.yaml#/antimesothelinmmae_antibodydrug_conjugate_rc88/common" + Anti-MUC16/CD3 Bispecific Antibody REGN4018: + $ref: + - "_terms_enum.yaml#/antimuc16cd3_bispecific_antibody_regn4018/common" + Anti-MUC17/CD3 BiTE Antibody AMG 199: + $ref: + - "_terms_enum.yaml#/antimuc17cd3_bite_antibody_amg_199/common" + Anti-NaPi2b Antibody-drug Conjugate XMT-1592: + $ref: + - "_terms_enum.yaml#/antinapi2b_antibodydrug_conjugate_xmt1592/common" + Anti-NRP1 Antibody ASP1948: + $ref: + - "_terms_enum.yaml#/antinrp1_antibody_asp1948/common" + Anti-OX40 Agonist Monoclonal Antibody BGB-A445: + $ref: + - "_terms_enum.yaml#/antiox40_agonist_monoclonal_antibody_bgba445/common" + Anti-OX40 Hexavalent Agonist Antibody INBRX-106: + $ref: + - "_terms_enum.yaml#/antiox40_hexavalent_agonist_antibody_inbrx106/common" + Anti-PD-1 Antibody-interleukin-21 Mutein Fusion Protein AMG 256: + $ref: + - "_terms_enum.yaml#/antipd1_antibodyinterleukin21_mutein_fusion_protein_amg_256/common" + Anti-PD-1 Monoclonal Antibody 609A: + $ref: + - "_terms_enum.yaml#/antipd1_monoclonal_antibody_609a/common" + Anti-PD-1 Monoclonal Antibody SCT-I10A: + $ref: + - "_terms_enum.yaml#/antipd1_monoclonal_antibody_scti10a/common" + Anti-PD-1/Anti-HER2 Bispecific Antibody IBI315: + $ref: + - "_terms_enum.yaml#/antipd1antiher2_bispecific_antibody_ibi315/common" + Anti-PD-1/Anti-LAG-3 Bispecific Antibody RO7247669: + $ref: + - "_terms_enum.yaml#/antipd1antilag3_bispecific_antibody_ro7247669/common" + Anti-PD-1/Anti-PD-L1 Bispecific Antibody IBI318: + $ref: + - "_terms_enum.yaml#/antipd1antipdl1_bispecific_antibody_ibi318/common" + Anti-PD-1/CD47 Infusion Protein HX009: + $ref: + - "_terms_enum.yaml#/antipd1cd47_infusion_protein_hx009/common" + Anti-PD-1/CTLA-4 Bispecific Antibody MEDI5752: + $ref: + - "_terms_enum.yaml#/antipd1ctla4_bispecific_antibody_medi5752/common" + Anti-PD-1/VEGF Bispecific Antibody AK112: + $ref: + - "_terms_enum.yaml#/antipd1vegf_bispecific_antibody_ak112/common" + Anti-PD-L1 Monoclonal Antibody IMC-001: + $ref: + - "_terms_enum.yaml#/antipdl1_monoclonal_antibody_imc001/common" + Anti-PD-L1 Monoclonal Antibody RC98: + $ref: + - "_terms_enum.yaml#/antipdl1_monoclonal_antibody_rc98/common" + Anti-PD-L1/Anti-4-1BB Bispecific Monoclonal Antibody GEN1046: + $ref: + - "_terms_enum.yaml#/antipdl1anti41bb_bispecific_monoclonal_antibody_gen1046/common" + Anti-PD-L1/IL-15 Fusion Protein KD033: + $ref: + - "_terms_enum.yaml#/antipdl1il15_fusion_protein_kd033/common" + Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C: + $ref: + - "_terms_enum.yaml#/antiprame_tcell_receptoranticd3_scfv_fusion_protein_imcf106c/common" + Anti-PSMA/CD3 Bispecific Antibody CCW702: + $ref: + - "_terms_enum.yaml#/antipsmacd3_bispecific_antibody_ccw702/common" + Anti-RANKL Monoclonal Antibody GB-223: + $ref: + - "_terms_enum.yaml#/antirankl_monoclonal_antibody_gb223/common" + Anti-RANKL Monoclonal Antibody JMT103: + $ref: + - "_terms_enum.yaml#/antirankl_monoclonal_antibody_jmt103/common" + Anti-Ribonucleoprotein Antibody ATRC-101: + $ref: + - "_terms_enum.yaml#/antiribonucleoprotein_antibody_atrc101/common" + Anti-ROR1/PNU-159682 Derivative Antibody-drug Conjugate NBE-002: + $ref: + - "_terms_enum.yaml#/antiror1pnu159682_derivative_antibodydrug_conjugate_nbe002/common" + Anti-TIGIT Monoclonal Antibody BGB-A1217: + $ref: + - "_terms_enum.yaml#/antitigit_monoclonal_antibody_bgba1217/common" + Anti-TIGIT Monoclonal Antibody COM902: + $ref: + - "_terms_enum.yaml#/antitigit_monoclonal_antibody_com902/common" + Anti-TIGIT Monoclonal Antibody SGN-TGT: + $ref: + - "_terms_enum.yaml#/antitigit_monoclonal_antibody_sgntgt/common" + Anti-TIM3 Monoclonal Antibody SHR-1702: + $ref: + - "_terms_enum.yaml#/antitim3_monoclonal_antibody_shr1702/common" + Anti-TRAILR2/CDH17 Tetravalent Bispecific Antibody BI 905711: + $ref: + - "_terms_enum.yaml#/antitrailr2cdh17_tetravalent_bispecific_antibody_bi_905711/common" + Anti-TROP2 Antibody-drug Conjugate BAT8003: + $ref: + - "_terms_enum.yaml#/antitrop2_antibodydrug_conjugate_bat8003/common" + Anti-TROP2 Antibody-drug Conjugate SKB264: + $ref: + - "_terms_enum.yaml#/antitrop2_antibodydrug_conjugate_skb264/common" + Anti-VEGFR2 Monoclonal Antibody MSB0254: + $ref: + - "_terms_enum.yaml#/antivegfr2_monoclonal_antibody_msb0254/common" + Antisense Oligonucleotide QR-313: + $ref: + - "_terms_enum.yaml#/antisense_oligonucleotide_qr313/common" + Aprinocarsen: + $ref: + - "_terms_enum.yaml#/aprinocarsen/common" + Aprutumab: + $ref: + - "_terms_enum.yaml#/aprutumab/common" + Aryl Hydrocarbon Receptor Inhibitor IK-175: + $ref: + - "_terms_enum.yaml#/aryl_hydrocarbon_receptor_inhibitor_ik175/common" + Aspacytarabine: + $ref: + - "_terms_enum.yaml#/aspacytarabine/common" + Asunercept: + $ref: + - "_terms_enum.yaml#/asunercept/common" + ATR Inhibitor RP-3500: + $ref: + - "_terms_enum.yaml#/atr_inhibitor_rp3500/common" + ATR Kinase Inhibitor M1774: + $ref: + - "_terms_enum.yaml#/atr_kinase_inhibitor_m1774/common" + Attenuated Measles Virus Encoding SCD Transgene TMV-018: + $ref: + - "_terms_enum.yaml#/attenuated_measles_virus_encoding_scd_transgene_tmv018/common" + Atuveciclib: + $ref: + - "_terms_enum.yaml#/atuveciclib/common" + Audencel: + $ref: + - "_terms_enum.yaml#/audencel/common" + Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055: + $ref: + - "_terms_enum.yaml#/autologous_afp_specific_t_cell_receptor_transduced_t_cells_ctcr055/common" + Autologous Anti-BCMA CAR T-cells PHE885: + $ref: + - "_terms_enum.yaml#/autologous_antibcma_car_tcells_phe885/common" + Autologous Anti-BCMA CD8+ CAR T-cells Descartes-11: + $ref: + - "_terms_enum.yaml#/autologous_antibcma_cd8_car_tcells_descartes11/common" + Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088: + $ref: + - "_terms_enum.yaml#/autologous_antibcmacar41bbcd3zetaexpressing_tcells_ccar088/common" + Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx: + $ref: + - "_terms_enum.yaml#/autologous_anticd19_car_tcells_19t228z1xx/common" + Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19: + $ref: + - "_terms_enum.yaml#/autologous_anticd19_car41bbcd3zetaexpressing_tcells_cnct19/common" + Autologous Anti-CD19 Chimeric Antigen Receptor T-cells AUTO1: + $ref: + - "_terms_enum.yaml#/autologous_anticd19_chimeric_antigen_receptor_tcells_auto1/common" + Autologous Anti-CD19 TAC-T cells TAC01-CD19: + $ref: + - "_terms_enum.yaml#/autologous_anticd19_tact_cells_tac01cd19/common" + Autologous Anti-CD19/CD20 Bispecific Nanobody-based CAR-T cells: + $ref: + - "_terms_enum.yaml#/autologous_anticd19cd20_bispecific_nanobodybased_cart_cells/common" + Autologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells: + $ref: + - "_terms_enum.yaml#/autologous_anticd19carher2tcd22caregfrtexpressing_tcells/common" + Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1: + $ref: + - "_terms_enum.yaml#/autologous_anticd20_car_transduced_cd4cd8_enriched_tcells_mbcart201/common" + Autologous Anti-CD123 CAR-T Cells: + $ref: + - "_terms_enum.yaml#/autologous_anticd123_cart_cells/common" + Autologous Anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes: + $ref: + - "_terms_enum.yaml#/autologous_antiegfr_cartransduced_cxcr_5modified_tlymphocytes/common" + Autologous Anti-FLT3 CAR T Cells AMG 553: + $ref: + - "_terms_enum.yaml#/autologous_antiflt3_car_t_cells_amg_553/common" + Autologous Anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T-cells AIC100: + $ref: + - "_terms_enum.yaml#/autologous_antiicam1carcd2841bbcd3zetaexpressing_tcells_aic100/common" + Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes: + $ref: + - "_terms_enum.yaml#/autologous_antikappa_light_chain_carcd28expressing_tlymphocytes/common" + Autologous Anti-PD-1 Antibody-activated Tumor-infiltrating Lymphocytes: + $ref: + - "_terms_enum.yaml#/autologous_antipd1_antibodyactivated_tumorinfiltrating_lymphocytes/common" + Autologous Anti-PSMA CAR-T Cells P-PSMA-101: + $ref: + - "_terms_enum.yaml#/autologous_antipsma_cart_cells_ppsma101/common" + Autologous BCMA-targeted CAR T Cells CC-98633: + $ref: + - "_terms_enum.yaml#/autologous_bcmatargeted_car_t_cells_cc98633/common" + Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F: + $ref: + - "_terms_enum.yaml#/autologous_bispecific_bcmacd19targeted_cart_cells_gc012f/common" + Autologous Bispecific CD19/CD22-targeted CAR-T Cells GC022: + $ref: + - "_terms_enum.yaml#/autologous_bispecific_cd19cd22targeted_cart_cells_gc022/common" + Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1: + $ref: + - "_terms_enum.yaml#/autologous_cd19_carexpressing_cd4cd8_tcells_mbcart191/common" + Autologous CD19-targeted CAR T Cells CC-97540: + $ref: + - "_terms_enum.yaml#/autologous_cd19targeted_car_t_cells_cc97540/common" + Autologous CD19-targeted CAR-T Cells GC007F: + $ref: + - "_terms_enum.yaml#/autologous_cd19targeted_cart_cells_gc007f/common" + Autologous CD19/PD-1 Bispecific CAR-T Cells: + $ref: + - "_terms_enum.yaml#/autologous_cd19pd1_bispecific_cart_cells/common" + Autologous Clonal Neoantigen T Cells ATL001: + $ref: + - "_terms_enum.yaml#/autologous_clonal_neoantigen_t_cells_atl001/common" + Autologous CRISPR-edited Anti-CD19 CAR T Cells XYF19: + $ref: + - "_terms_enum.yaml#/autologous_crispredited_anticd19_car_t_cells_xyf19/common" + Autologous Monocyte-derived Lysate-pulsed Dendritic Cell Vaccine PV-001-DC: + $ref: + - "_terms_enum.yaml#/autologous_monocytederived_lysatepulsed_dendritic_cell_vaccine_pv001dc/common" + Autologous Multi-lineage Potential Cells: + $ref: + - "_terms_enum.yaml#/autologous_multilineage_potential_cells/common" + Autologous Nectin-4/FAP-targeted CAR-T Cells: + $ref: + - "_terms_enum.yaml#/autologous_nectin4faptargeted_cart_cells/common" + Autologous NKG2D CAR T-cells CYAD-02: + $ref: + - "_terms_enum.yaml#/autologous_nkg2d_car_tcells_cyad02/common" + Autologous Pancreatic Adenocarcinoma Lysate and mRNA-loaded Dendritic Cell Vaccine: + $ref: + - "_terms_enum.yaml#/autologous_pancreatic_adenocarcinoma_lysate_and_mrnaloaded_dendritic_cell_vaccine/common" + Autologous Peripheral Blood Lymphocytes from Ibrutinib-treated Chronic Lymphocytic Leukemia Patients IOV-2001: + $ref: + - "_terms_enum.yaml#/autologous_peripheral_blood_lymphocytes_from_ibrutinibtreated_chronic_lymphocytic_leukemia_patients_iov2001/common" + Autologous Rapamycin-resistant Th1/Tc1 Cells RAPA-201: + $ref: + - "_terms_enum.yaml#/autologous_rapamycinresistant_th1tc1_cells_rapa201/common" + Autologous TCRm-expressing T-cells ET140203: + $ref: + - "_terms_enum.yaml#/autologous_tcrmexpressing_tcells_et140203/common" + Autologous Tetravalent Dendritic Cell Vaccine MIDRIX4-LUNG: + $ref: + - "_terms_enum.yaml#/autologous_tetravalent_dendritic_cell_vaccine_midrix4lung/common" + Autologous Tumor Infiltrating Lymphocytes LN-145-S1: + $ref: + - "_terms_enum.yaml#/autologous_tumor_infiltrating_lymphocytes_ln145s1/common" + Autologous Universal CAR-expressing T-lymphocytes UniCAR02-T: + $ref: + - "_terms_enum.yaml#/autologous_universal_carexpressing_tlymphocytes_unicar02t/common" + Avdoralimab: + $ref: + - "_terms_enum.yaml#/avdoralimab/common" + Aviscumine: + $ref: + - "_terms_enum.yaml#/aviscumine/common" + Axalimogene Filolisbac: + $ref: + - "_terms_enum.yaml#/axalimogene_filolisbac/common" + Axatilimab: + $ref: + - "_terms_enum.yaml#/axatilimab/common" + AXL Inhibitor SLC-391: + $ref: + - "_terms_enum.yaml#/axl_inhibitor_slc391/common" + AXL/ FLT3/VEGFR2 Inhibitor KC1036: + $ref: + - "_terms_enum.yaml#/axl_flt3vegfr2_inhibitor_kc1036/common" + Axl/Mer Inhibitor PF-07265807: + $ref: + - "_terms_enum.yaml#/axlmer_inhibitor_pf07265807/common" + Azintuxizumab Vedotin: + $ref: + - "_terms_enum.yaml#/azintuxizumab_vedotin/common" + Balstilimab: + $ref: + - "_terms_enum.yaml#/balstilimab/common" + Bazlitoran: + $ref: + - "_terms_enum.yaml#/bazlitoran/common" + Bcl-2 Inhibitor BGB-11417: + $ref: + - "_terms_enum.yaml#/bcl2_inhibitor_bgb11417/common" + Bcl-2 Inhibitor LP-108: + $ref: + - "_terms_enum.yaml#/bcl2_inhibitor_lp108/common" + BCMA-CD19 Compound CAR T Cells: + $ref: + - "_terms_enum.yaml#/bcmacd19_compound_car_t_cells/common" + BCMA/CD3e Tri-specific T-cell Activating Construct HPN217: + $ref: + - "_terms_enum.yaml#/bcmacd3e_trispecific_tcell_activating_construct_hpn217/common" + Belantamab Mafodotin: + $ref: + - "_terms_enum.yaml#/belantamab_mafodotin/common" + Belapectin: + $ref: + - "_terms_enum.yaml#/belapectin/common" + Belvarafenib: + $ref: + - "_terms_enum.yaml#/belvarafenib/common" + Belzutifan: + $ref: + - "_terms_enum.yaml#/belzutifan/common" + Bersanlimab: + $ref: + - "_terms_enum.yaml#/bersanlimab/common" + Berzosertib: + $ref: + - "_terms_enum.yaml#/berzosertib/common" + Betaglucin Gel: + $ref: + - "_terms_enum.yaml#/betaglucin_gel/common" + Bexmarilimab: + $ref: + - "_terms_enum.yaml#/bexmarilimab/common" + Bispecific Antibody AGEN1223: + $ref: + - "_terms_enum.yaml#/bispecific_antibody_agen1223/common" + Bispecific Antibody AMG 509: + $ref: + - "_terms_enum.yaml#/bispecific_antibody_amg_509/common" + Bispecific Antibody GS-1423: + $ref: + - "_terms_enum.yaml#/bispecific_antibody_gs1423/common" + BiTE Antibody AMG 910: + $ref: + - "_terms_enum.yaml#/bite_antibody_amg_910/common" + Bizalimogene Ralaplasmid: + $ref: + - "_terms_enum.yaml#/bizalimogene_ralaplasmid/common" + Bomedemstat: + $ref: + - "_terms_enum.yaml#/bomedemstat/common" + BRAF Inhibitor BGB-3245: + $ref: + - "_terms_enum.yaml#/braf_inhibitor_bgb3245/common" + BRAF(V600E) Kinase Inhibitor ABM-1310: + $ref: + - "_terms_enum.yaml#/brafv600e_kinase_inhibitor_abm1310/common" + BTK Inhibitor HZ-A-018: + $ref: + - "_terms_enum.yaml#/btk_inhibitor_hza018/common" + c-Met Inhibitor ABN401: + $ref: + - "_terms_enum.yaml#/cmet_inhibitor_abn401/common" + c-Met Inhibitor GST-HG161: + $ref: + - "_terms_enum.yaml#/cmet_inhibitor_gsthg161/common" + C/EBP Beta Antagonist ST101: + $ref: + - "_terms_enum.yaml#/cebp_beta_antagonist_st101/common" + Calcium Release-activated Channel Inhibitor CM4620: + $ref: + - "_terms_enum.yaml#/calcium_releaseactivated_channel_inhibitor_cm4620/common" + Camidanlumab Tesirine: + $ref: + - "_terms_enum.yaml#/camidanlumab_tesirine/common" + Carbon C 14-pamiparib: + $ref: + - "_terms_enum.yaml#/carbon_c_14pamiparib/common" + Cationic Peptide Cream Cypep-1: + $ref: + - "_terms_enum.yaml#/cationic_peptide_cream_cypep1/common" + CD11b Agonist GB1275: + $ref: + - "_terms_enum.yaml#/cd11b_agonist_gb1275/common" + CD20-CD19 Compound CAR T Cells: + $ref: + - "_terms_enum.yaml#/cd20cd19_compound_car_t_cells/common" + CD28/ICOS Antagonist ALPN-101: + $ref: + - "_terms_enum.yaml#/cd28icos_antagonist_alpn101/common" + CD44v6-specific CAR T-cells: + $ref: + - "_terms_enum.yaml#/cd44v6specific_car_tcells/common" + CD73 Inhibitor AB680: + $ref: + - "_terms_enum.yaml#/cd73_inhibitor_ab680/common" + CD73 Inhibitor LY3475070: + $ref: + - "_terms_enum.yaml#/cd73_inhibitor_ly3475070/common" + CD80-Fc Fusion Protein ALPN-202: + $ref: + - "_terms_enum.yaml#/cd80fc_fusion_protein_alpn202/common" + CD80-Fc Fusion Protein FPT155: + $ref: + - "_terms_enum.yaml#/cd80fc_fusion_protein_fpt155/common" + CD123-CD33 Compound CAR T Cells: + $ref: + - "_terms_enum.yaml#/cd123cd33_compound_car_t_cells/common" + CD123-specific Targeting Module TM123: + $ref: + - "_terms_enum.yaml#/cd123specific_targeting_module_tm123/common" + CDK2 Inhibitor PF-07104091: + $ref: + - "_terms_enum.yaml#/cdk2_inhibitor_pf07104091/common" + CDK4/6 Inhibitor CS3002: + $ref: + - "_terms_enum.yaml#/cdk46_inhibitor_cs3002/common" + CDK4/6 Inhibitor HS-10342: + $ref: + - "_terms_enum.yaml#/cdk46_inhibitor_hs10342/common" + CDK4/6 Inhibitor TQB3616: + $ref: + - "_terms_enum.yaml#/cdk46_inhibitor_tqb3616/common" + CDK7 Inhibitor SY-5609: + $ref: + - "_terms_enum.yaml#/cdk7_inhibitor_sy5609/common" + CDK8/19 Inhibitor SEL 120: + $ref: + - "_terms_enum.yaml#/cdk819_inhibitor_sel_120/common" + Cedazuridine/Azacitidine Combination Agent ASTX030: + $ref: + - "_terms_enum.yaml#/cedazuridineazacitidine_combination_agent_astx030/common" + Cereblon E3 Ubiquitin Ligase Modulating Agent CC-99282: + $ref: + - "_terms_enum.yaml#/cereblon_e3_ubiquitin_ligase_modulating_agent_cc99282/common" + Cetuximab Sarotalocan: + $ref: + - "_terms_enum.yaml#/cetuximab_sarotalocan/common" + Cevostamab: + $ref: + - "_terms_enum.yaml#/cevostamab/common" + Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes: + $ref: + - "_terms_enum.yaml#/chlorotoxin_eqcd28cd3zetacd19texpressing_car_tlymphocytes/common" + Ciltacabtagene Autoleucel: + $ref: + - "_terms_enum.yaml#/ciltacabtagene_autoleucel/common" + Cinrebafusp Alfa: + $ref: + - "_terms_enum.yaml#/cinrebafusp_alfa/common" + Cintirorgon: + $ref: + - "_terms_enum.yaml#/cintirorgon/common" + CK1alpha/CDK7/CDK9 Inhibitor BTX-A51: + $ref: + - "_terms_enum.yaml#/ck1alphacdk7cdk9_inhibitor_btxa51/common" + Cobolimab: + $ref: + - "_terms_enum.yaml#/cobolimab/common" + Cofetuzumab Pelidotin: + $ref: + - "_terms_enum.yaml#/cofetuzumab_pelidotin/common" + Coltuximab Ravtansine: + $ref: + - "_terms_enum.yaml#/coltuximab_ravtansine/common" + Commensal Bacterial Strain Formulation VE800: + $ref: + - "_terms_enum.yaml#/commensal_bacterial_strain_formulation_ve800/common" + Copper Cu 67 Tyr3-octreotate: + $ref: + - "_terms_enum.yaml#/copper_cu_67_tyr3octreotate/common" + Cord Blood Derived CAR T-Cells: + $ref: + - "_terms_enum.yaml#/cord_blood_derived_car_tcells/common" + Cosibelimab: + $ref: + - "_terms_enum.yaml#/cosibelimab/common" + Coxsackievirus V937: + $ref: + - "_terms_enum.yaml#/coxsackievirus_v937/common" + CSF1R Inhibitor ABSK021: + $ref: + - "_terms_enum.yaml#/csf1r_inhibitor_absk021/common" + CXCR4/E-selectin Antagonist GMI-1359: + $ref: + - "_terms_enum.yaml#/cxcr4eselectin_antagonist_gmi1359/common" + CYP11A1 Inhibitor ODM-209: + $ref: + - "_terms_enum.yaml#/cyp11a1_inhibitor_odm209/common" + CYP17/CYP11B2 Inhibitor LAE001: + $ref: + - "_terms_enum.yaml#/cyp17cyp11b2_inhibitor_lae001/common" + Daratumumab and Hyaluronidase-fihj: + $ref: + - "_terms_enum.yaml#/daratumumab_and_hyaluronidasefihj/common" + Decitabine and Cedazuridine: + $ref: + - "_terms_enum.yaml#/decitabine_and_cedazuridine/common" + Delolimogene Mupadenorepvec: + $ref: + - "_terms_enum.yaml#/delolimogene_mupadenorepvec/common" + Dendrimer-conjugated Bcl-2/Bcl-XL Inhibitor AZD0466: + $ref: + - "_terms_enum.yaml#/dendrimerconjugated_bcl2bclxl_inhibitor_azd0466/common" + Dengue Virus Adjuvant PV-001-DV: + $ref: + - "_terms_enum.yaml#/dengue_virus_adjuvant_pv001dv/common" + Dilpacimab: + $ref: + - "_terms_enum.yaml#/dilpacimab/common" + DNA-PK inhibitor AZD7648: + $ref: + - "_terms_enum.yaml#/dnapk_inhibitor_azd7648/common" + DNA-PK/PI3K-delta Inhibitor BR101801: + $ref: + - "_terms_enum.yaml#/dnapkpi3kdelta_inhibitor_br101801/common" + DNMT1 Inhibitor NTX-301: + $ref: + - "_terms_enum.yaml#/dnmt1_inhibitor_ntx301/common" + Dociparstat sodium: + $ref: + - "_terms_enum.yaml#/dociparstat_sodium/common" + Dostarlimab: + $ref: + - "_terms_enum.yaml#/dostarlimab/common" + Doxorubicin Prodrug/Prodrug-activating Biomaterial SQ3370: + $ref: + - "_terms_enum.yaml#/doxorubicin_prodrugprodrugactivating_biomaterial_sq3370/common" + DTRMWXHS-12/Everolimus/Pomalidomide Combination Agent DTRM-555: + $ref: + - "_terms_enum.yaml#/dtrmwxhs12everolimuspomalidomide_combination_agent_dtrm555/common" + Edicotinib: + $ref: + - "_terms_enum.yaml#/edicotinib/common" + Edodekin alfa: + $ref: + - "_terms_enum.yaml#/edodekin_alfa/common" + Eftozanermin Alfa: + $ref: + - "_terms_enum.yaml#/eftozanermin_alfa/common" + EGFR Inhibitor TY-9591: + $ref: + - "_terms_enum.yaml#/egfr_inhibitor_ty9591/common" + EGFR Mutant-selective Inhibitor TQB3804: + $ref: + - "_terms_enum.yaml#/egfr_mutantselective__inhibitor_tqb3804/common" + EGFR/EGFRvIII Inhibitor WSD0922-FU: + $ref: + - "_terms_enum.yaml#/egfregfrviii_inhibitor_wsd0922fu/common" + EGFR/HER2 Inhibitor DZD9008: + $ref: + - "_terms_enum.yaml#/egfrher2_inhibitor_dzd9008/common" + EGFR/TGFb Fusion Monoclonal Antibody BCA101: + $ref: + - "_terms_enum.yaml#/egfrtgfb_fusion_monoclonal_antibody_bca101/common" + EGFR/VEGFR/RET Inhibitor HA121-28: + $ref: + - "_terms_enum.yaml#/egfrvegfrret_inhibitor_ha12128/common" + Emibetuzumab: + $ref: + - "_terms_enum.yaml#/emibetuzumab/common" + Enadenotucirev-expressing FAP/CD3 Bispecific FAP-TAc NG-641: + $ref: + - "_terms_enum.yaml#/enadenotucirevexpressing_fapcd3_bispecific_faptac_ng641/common" + Encapsulated Rapamycin: + $ref: + - "_terms_enum.yaml#/encapsulated_rapamycin/common" + Encelimab: + $ref: + - "_terms_enum.yaml#/encelimab/common" + Endothelin B Receptor Blocker ENB 003: + $ref: + - "_terms_enum.yaml#/endothelin_b_receptor_blocker_enb_003/common" + Engineered Red Blood Cells Co-expressing 4-1BBL and IL-15TP RTX-240: + $ref: + - "_terms_enum.yaml#/engineered_red_blood_cells_coexpressing_41bbl_and_il15tp_rtx240/common" + Engineered Toxin Body Targeting CD38 TAK-169: + $ref: + - "_terms_enum.yaml#/engineered_toxin_body_targeting_cd38_tak169/common" + EP2/EP4 Antagonist TPST-1495: + $ref: + - "_terms_enum.yaml#/ep2ep4_antagonist_tpst1495/common" + EP4 Antagonist INV-1120: + $ref: + - "_terms_enum.yaml#/ep4_antagonist_inv1120/common" + Epcoritamab: + $ref: + - "_terms_enum.yaml#/epcoritamab/common" + EphA2-targeting Bicycle Toxin Conjugate BT5528: + $ref: + - "_terms_enum.yaml#/epha2targeting_bicycle_toxin_conjugate_bt5528/common" + ERK1/2 Inhibitor HH2710: + $ref: + - "_terms_enum.yaml#/erk12_inhibitor_hh2710/common" + ERK1/2 Inhibitor JSI-1187: + $ref: + - "_terms_enum.yaml#/erk12_inhibitor_jsi1187/common" + Etigilimab: + $ref: + - "_terms_enum.yaml#/etigilimab/common" + Exicorilant: + $ref: + - "_terms_enum.yaml#/exicorilant/common" + Extended Release Metformin Hydrochloride: + $ref: + - "_terms_enum.yaml#/extended_release_metformin_hydrochloride/common" + Ezabenlimab: + $ref: + - "_terms_enum.yaml#/ezabenlimab/common" + EZH1/2 Inhibitor HH2853: + $ref: + - "_terms_enum.yaml#/ezh12_inhibitor_hh2853/common" + EZH2 inhibitor CPI-0209: + $ref: + - "_terms_enum.yaml#/ezh2_inhibitor_cpi0209/common" + Fadraciclib: + $ref: + - "_terms_enum.yaml#/fadraciclib/common" + FAK/ALK/ROS1 Inhibitor APG-2449: + $ref: + - "_terms_enum.yaml#/fakalkros1_inhibitor_apg2449/common" + FAP/4-1BB-targeting DARPin MP0310: + $ref: + - "_terms_enum.yaml#/fap41bbtargeting_darpin_mp0310/common" + FAP/4-1BB-targeting Fusion Protein RO7122290: + $ref: + - "_terms_enum.yaml#/fap41bbtargeting_fusion_protein_ro7122290/common" + Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells: + $ref: + - "_terms_enum.yaml#/fas_ligandtreated_allogeneic_mobilized_peripheral_blood_cells/common" + Favezelimab: + $ref: + - "_terms_enum.yaml#/favezelimab/common" + Fc-engineered Anti-CD40 Agonist Antibody 2141-V11: + $ref: + - "_terms_enum.yaml#/fcengineered_anticd40_agonist_antibody_2141v11/common" + Feladilimab: + $ref: + - "_terms_enum.yaml#/feladilimab/common" + Felzartamab: + $ref: + - "_terms_enum.yaml#/felzartamab/common" + Fenretinide Phospholipid Suspension ST-001: + $ref: + - "_terms_enum.yaml#/fenretinide_phospholipid_suspension_st001/common" + FGFR2 Inhibitor RLY-4008: + $ref: + - "_terms_enum.yaml#/fgfr2_inhibitor_rly4008/common" + FGFR Inhibitor CPL304110: + $ref: + - "_terms_enum.yaml#/fgfr_inhibitor_cpl304110/common" + FGFR/CSF-1R Inhibitor 3D185: + $ref: + - "_terms_enum.yaml#/fgfrcsf1r_inhibitor_3d185/common" + Fianlimab: + $ref: + - "_terms_enum.yaml#/fianlimab/common" + Fimaporfin A: + $ref: + - "_terms_enum.yaml#/fimaporfin_a/common" + Flt3 Ligand/Anti-CTLA-4 Antibody/IL-12 Engineered Oncolytic Vaccinia Virus RIVAL-01: + $ref: + - "_terms_enum.yaml#/flt3_ligandantictla4_antibodyil12_engineered_oncolytic_vaccinia_virus_rival01/common" + FLT3/FGFR Dual Kinase Inhibitor MAX-40279: + $ref: + - "_terms_enum.yaml#/flt3fgfr_dual_kinase_inhibitor_max40279/common" + FLT3/KIT/CSF1R Inhibitor NMS-03592088: + $ref: + - "_terms_enum.yaml#/flt3kitcsf1r_inhibitor_nms03592088/common" + Fluorine F 18 Ara-G: + $ref: + - "_terms_enum.yaml#/fluorine_f_18_arag/common" + Foritinib Succinate: + $ref: + - "_terms_enum.yaml#/foritinib_succinate/common" + Fosgemcitabine Palabenamide: + $ref: + - "_terms_enum.yaml#/fosgemcitabine_palabenamide/common" + Fosifloxuridine Nafalbenamide: + $ref: + - "_terms_enum.yaml#/fosifloxuridine_nafalbenamide/common" + Futibatinib: + $ref: + - "_terms_enum.yaml#/futibatinib/common" + G Protein-coupled Estrogen Receptor Agonist LNS8801: + $ref: + - "_terms_enum.yaml#/g_proteincoupled_estrogen_receptor_agonist_lns8801/common" + Gallium-based Bone Resorption Inhibitor AP-002: + $ref: + - "_terms_enum.yaml#/galliumbased_bone_resorption_inhibitor_ap002/common" + GBM Antigens and Alloantigens Immunotherapeutic Vaccine: + $ref: + - "_terms_enum.yaml#/gbm_antigens_and_alloantigens_immunotherapeutic_vaccine/common" + Genetically Modified Interleukin-12 Transgene-encoding Bifidobacterium longum: + $ref: + - "_terms_enum.yaml#/genetically_modified_interleukin12_transgeneencoding_bifidobacterium_longum/common" + Giloralimab: + $ref: + - "_terms_enum.yaml#/giloralimab/common" + Giredestrant: + $ref: + - "_terms_enum.yaml#/giredestrant/common" + Glofitamab: + $ref: + - "_terms_enum.yaml#/glofitamab/common" + Glutaminase Inhibitor IPN60090: + $ref: + - "_terms_enum.yaml#/glutaminase_inhibitor_ipn60090/common" + Glutamine Antagonist DRP-104: + $ref: + - "_terms_enum.yaml#/glutamine_antagonist_drp104/common" + HER2 Inhibitor DZD1516: + $ref: + - "_terms_enum.yaml#/her2_inhibitor_dzd1516/common" + HER2 Tri-specific Natural Killer Cell Engager DF1001: + $ref: + - "_terms_enum.yaml#/her2_trispecific_natural_killer_cell_engager_df1001/common" + HER2-directed TLR8 Agonist SBT6050: + $ref: + - "_terms_enum.yaml#/her2directed_tlr8_agonist_sbt6050/common" + HIF2a RNAi ARO-HIF2: + $ref: + - "_terms_enum.yaml#/hif2a_rnai_arohif2/common" + HPV6/11-targeted DNA Plasmid Vaccine INO-3107: + $ref: + - "_terms_enum.yaml#/hpv611targeted_dna_plasmid_vaccine_ino3107/common" + HPV 16 E6/E7-encoding Arenavirus Vaccine HB-202: + $ref: + - "_terms_enum.yaml#/hpv_16_e6e7encoding_arenavirus_vaccine_hb202/common" + HPV E6/E7-encoding Arenavirus Vaccine HB-201: + $ref: + - "_terms_enum.yaml#/hpv_e6e7encoding_arenavirus_vaccine_hb201/common" + Hsp90 Inhibitor TQB3474: + $ref: + - "_terms_enum.yaml#/hsp90_inhibitor_tqb3474/common" + Hsp90-targeted Photosensitizer HS-201: + $ref: + - "_terms_enum.yaml#/hsp90targeted_photosensitizer_hs201/common" + Hyaluronidase-zzxf/Pertuzumab/Trastuzumab: + $ref: + - "_terms_enum.yaml#/hyaluronidasezzxfpertuzumabtrastuzumab/common" + Iadademstat: + $ref: + - "_terms_enum.yaml#/iadademstat/common" + Ianalumab: + $ref: + - "_terms_enum.yaml#/ianalumab/common" + Idetrexed: + $ref: + - "_terms_enum.yaml#/idetrexed/common" + IDH1 Mutant Inhibitor LY3410738: + $ref: + - "_terms_enum.yaml#/idh1_mutant_inhibitor_ly3410738/common" + IDO1/TDO2 Inhibitor M4112: + $ref: + - "_terms_enum.yaml#/ido1tdo2_inhibitor_m4112/common" + IDO/TDO Inhibitor LY-01013: + $ref: + - "_terms_enum.yaml#/idotdo_inhibitor_ly01013/common" + Ieramilimab: + $ref: + - "_terms_enum.yaml#/ieramilimab/common" + IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000: + $ref: + - "_terms_enum.yaml#/il12sc_il15sushi_ifna_and_gmcsf_mrnabased_immunotherapeutic_agent_sar441000/common" + Ilginatinib: + $ref: + - "_terms_enum.yaml#/ilginatinib/common" + Imaradenant: + $ref: + - "_terms_enum.yaml#/imaradenant/common" + Imgatuzumab: + $ref: + - "_terms_enum.yaml#/imgatuzumab/common" + Imifoplatin: + $ref: + - "_terms_enum.yaml#/imifoplatin/common" + Inactivated Oncolytic Virus Particle GEN0101: + $ref: + - "_terms_enum.yaml#/inactivated_oncolytic_virus_particle_gen0101/common" + Indatuximab Ravtansine: + $ref: + - "_terms_enum.yaml#/indatuximab_ravtansine/common" + Individualized MVA-based Vaccine TG4050: + $ref: + - "_terms_enum.yaml#/individualized_mvabased_vaccine_tg4050/common" + Indusatumab Vedotin: + $ref: + - "_terms_enum.yaml#/indusatumab_vedotin/common" + Inebilizumab: + $ref: + - "_terms_enum.yaml#/inebilizumab/common" + iNKT Cell Agonist ABX196: + $ref: + - "_terms_enum.yaml#/inkt_cell_agonist_abx196/common" + Interleukin-12-Fc Fusion Protein DF6002: + $ref: + - "_terms_enum.yaml#/interleukin12fc_fusion_protein_df6002/common" + Interleukin-15 Agonist Fusion Protein SHR1501: + $ref: + - "_terms_enum.yaml#/interleukin15_agonist_fusion_protein_shr1501/common" + Interleukin-15 Fusion Protein BJ-001: + $ref: + - "_terms_enum.yaml#/interleukin15_fusion_protein_bj001/common" + Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306: + $ref: + - "_terms_enum.yaml#/interleukin15interleukin15_receptor_alpha_complexfc_fusion_protein_xmab24306/common" + Interleukin-15/Interleukin-15 Receptor Alpha Sushi+ Domain Fusion Protein SO-C101: + $ref: + - "_terms_enum.yaml#/interleukin15interleukin15_receptor_alpha_sushi_domain_fusion_protein_soc101/common" + Iodine I 131 Apamistamab: + $ref: + - "_terms_enum.yaml#/iodine_i_131_apamistamab/common" + Iodine I 131 IPA: + $ref: + - "_terms_enum.yaml#/iodine_i_131_ipa/common" + iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596: + $ref: + - "_terms_enum.yaml#/ipscderived_cd16il15rfexpressing_anticd19_carnk_cells_ft596/common" + Irinotecan Sucrosofate: + $ref: + - "_terms_enum.yaml#/irinotecan_sucrosofate/common" + Iroplact: + $ref: + - "_terms_enum.yaml#/iroplact/common" + Irradiated Allogeneic Human Lung Cancer Cells Expressing OX40L-Ig Vaccine HS-130: + $ref: + - "_terms_enum.yaml#/irradiated_allogeneic_human_lung_cancer_cells_expressing_ox40lig_vaccine_hs130/common" + Istiratumab: + $ref: + - "_terms_enum.yaml#/istiratumab/common" + Ivaltinostat: + $ref: + - "_terms_enum.yaml#/ivaltinostat/common" + Ivuxolimab: + $ref: + - "_terms_enum.yaml#/ivuxolimab/common" + JAK Inhibitor: + $ref: + - "_terms_enum.yaml#/jak_inhibitor/common" + Kanitinib: + $ref: + - "_terms_enum.yaml#/kanitinib/common" + KRAS G12C Inhibitor GDC-6036: + $ref: + - "_terms_enum.yaml#/kras_g12c_inhibitor_gdc6036/common" + KRAS G12C Inhibitor LY3499446: + $ref: + - "_terms_enum.yaml#/kras_g12c_inhibitor_ly3499446/common" + KRASG12C Inhibitor JNJ-74699157: + $ref: + - "_terms_enum.yaml#/krasg12c_inhibitor_jnj74699157/common" + Ladiratuzumab Vedotin: + $ref: + - "_terms_enum.yaml#/ladiratuzumab_vedotin/common" + LAIR-2 Fusion Protein NC410: + $ref: + - "_terms_enum.yaml#/lair2_fusion_protein_nc410/common" + Landogrozumab: + $ref: + - "_terms_enum.yaml#/landogrozumab/common" + Laprituximab Emtansine: + $ref: + - "_terms_enum.yaml#/laprituximab_emtansine/common" + Larotinib Mesylate: + $ref: + - "_terms_enum.yaml#/larotinib_mesylate/common" + Lerociclib: + $ref: + - "_terms_enum.yaml#/lerociclib/common" + Letetresgene Autoleucel: + $ref: + - "_terms_enum.yaml#/letetresgene_autoleucel/common" + Letolizumab: + $ref: + - "_terms_enum.yaml#/letolizumab/common" + Lifileucel: + $ref: + - "_terms_enum.yaml#/lifileucel/common" + Lifirafenib: + $ref: + - "_terms_enum.yaml#/lifirafenib/common" + Lilotomab: + $ref: + - "_terms_enum.yaml#/lilotomab/common" + Linperlisib: + $ref: + - "_terms_enum.yaml#/linperlisib/common" + Lipid Nanoparticle Encapsulating Glutathione S-transferase P siRNA NBF-006: + $ref: + - "_terms_enum.yaml#/lipid_nanoparticle_encapsulating_glutathione_stransferase_p_sirna_nbf006/common" + Liposomal Bcl-2 Antisense Oligonucleotide BP1002: + $ref: + - "_terms_enum.yaml#/liposomal_bcl2_antisense_oligonucleotide__bp1002/common" + Liposome-encapsulated TAAs mRNA Vaccine W_ova1: + $ref: + - "_terms_enum.yaml#/liposomeencapsulated_taas_mrna_vaccine_w_ova1/common" + LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes: + $ref: + - "_terms_enum.yaml#/lmp2specific_t_cell_receptortransduced_autologous_tlymphocytes/common" + LMP7 Inhibitor M3258: + $ref: + - "_terms_enum.yaml#/lmp7_inhibitor_m3258/common" + Lodapolimab: + $ref: + - "_terms_enum.yaml#/lodapolimab/common" + LRP5 Antagonist BI 905681: + $ref: + - "_terms_enum.yaml#/lrp5_antagonist_bi_905681/common" + LSD1 Inhibitor SYHA1807: + $ref: + - "_terms_enum.yaml#/lsd1_inhibitor_syha1807/common" + Lumretuzumab: + $ref: + - "_terms_enum.yaml#/lumretuzumab/common" + Lupartumab Amadotin: + $ref: + - "_terms_enum.yaml#/lupartumab_amadotin/common" + Lutetium Lu 177-DTPA-omburtamab: + $ref: + - "_terms_enum.yaml#/lutetium_lu_177dtpaomburtamab/common" + Maackia amurensis Seed Lectin: + $ref: + - "_terms_enum.yaml#/maackia_amurensis_seed_lectin/common" + Macrocycle-bridged STING Agonist E7766: + $ref: + - "_terms_enum.yaml#/macrocyclebridged_sting_agonist_e7766/common" + MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells: + $ref: + - "_terms_enum.yaml#/magea1specific_t_cell_receptortransduced_autologous_tcells/common" + Magrolimab: + $ref: + - "_terms_enum.yaml#/magrolimab/common" + Manelimab: + $ref: + - "_terms_enum.yaml#/manelimab/common" + MCL-1 Inhibitor ABBV-467: + $ref: + - "_terms_enum.yaml#/mcl1_inhibitor_abbv467/common" + MDM2 Inhibitor AMGMDS3: + $ref: + - "_terms_enum.yaml#/mdm2_inhibitor_amgmds3/common" + MEK 1/2 Inhibitor FCN-159: + $ref: + - "_terms_enum.yaml#/mek_12_inhibitor_fcn159/common" + MEK Inhibitor HL-085: + $ref: + - "_terms_enum.yaml#/mek_inhibitor_hl085/common" + Menin-MLL Interaction Inhibitor SNDX-5613: + $ref: + - "_terms_enum.yaml#/meninmll_interaction_inhibitor_sndx5613/common" + MET x MET Bispecific Antibody REGN5093: + $ref: + - "_terms_enum.yaml#/met_x_met_bispecific_antibody_regn5093/common" + Metarrestin: + $ref: + - "_terms_enum.yaml#/metarrestin/common" + Methylcantharidimide: + $ref: + - "_terms_enum.yaml#/methylcantharidimide/common" + Mevociclib: + $ref: + - "_terms_enum.yaml#/mevociclib/common" + Mezagitamab: + $ref: + - "_terms_enum.yaml#/mezagitamab/common" + Microbiome GEN-001: + $ref: + - "_terms_enum.yaml#/microbiome_gen001/common" + Microbiome-derived Peptide Vaccine EO2401: + $ref: + - "_terms_enum.yaml#/microbiomederived_peptide_vaccine_eo2401/common" + Milataxel: + $ref: + - "_terms_enum.yaml#/milataxel/common" + Miptenalimab: + $ref: + - "_terms_enum.yaml#/miptenalimab/common" + Miransertib: + $ref: + - "_terms_enum.yaml#/miransertib/common" + Mirdametinib: + $ref: + - "_terms_enum.yaml#/mirdametinib/common" + Mirzotamab Clezutoclax: + $ref: + - "_terms_enum.yaml#/mirzotamab_clezutoclax/common" + Mitazalimab: + $ref: + - "_terms_enum.yaml#/mitazalimab/common" + Mobocertinib: + $ref: + - "_terms_enum.yaml#/mobocertinib/common" + Modakafusp Alfa: + $ref: + - "_terms_enum.yaml#/modakafusp_alfa/common" + Modified Vaccinia Ankara-vectored HPV16/18 Vaccine JNJ-65195208: + $ref: + - "_terms_enum.yaml#/modified_vaccinia_ankaravectored_hpv1618_vaccine_jnj65195208/common" + Motixafortide: + $ref: + - "_terms_enum.yaml#/motixafortide/common" + MUC-1/WT1 Peptide-primed Autologous Dendritic Cells: + $ref: + - "_terms_enum.yaml#/muc1wt1_peptideprimed_autologous_dendritic_cells/common" + Multi-epitope HER2 Peptide Vaccine TPIV100: + $ref: + - "_terms_enum.yaml#/multiepitope_her2_peptide_vaccine_tpiv100/common" + Murizatoclax: + $ref: + - "_terms_enum.yaml#/murizatoclax/common" + Muscadine Grape Extract: + $ref: + - "_terms_enum.yaml#/muscadine_grape_extract/common" + MVA-BN Smallpox Vaccine: + $ref: + - "_terms_enum.yaml#/mvabn_smallpox_vaccine/common" + N-dihydrogalactochitosan: + $ref: + - "_terms_enum.yaml#/ndihydrogalactochitosan/common" + Nagrestipen: + $ref: + - "_terms_enum.yaml#/nagrestipen/common" + Naratuximab Emtansine: + $ref: + - "_terms_enum.yaml#/naratuximab_emtansine/common" + Navicixizumab: + $ref: + - "_terms_enum.yaml#/navicixizumab/common" + Nogapendekin Alfa: + $ref: + - "_terms_enum.yaml#/nogapendekin_alfa/common" + Numidargistat: + $ref: + - "_terms_enum.yaml#/numidargistat/common" + Nurulimab: + $ref: + - "_terms_enum.yaml#/nurulimab/common" + Odronextamab: + $ref: + - "_terms_enum.yaml#/odronextamab/common" + Ofranergene Obadenovec: + $ref: + - "_terms_enum.yaml#/ofranergene_obadenovec/common" + Oligo-fucoidan: + $ref: + - "_terms_enum.yaml#/oligofucoidan/common" + Olinvacimab: + $ref: + - "_terms_enum.yaml#/olinvacimab/common" + Olvimulogene Nanivacirepvec: + $ref: + - "_terms_enum.yaml#/olvimulogene_nanivacirepvec/common" + Onatasertib: + $ref: + - "_terms_enum.yaml#/onatasertib/common" + Oncolytic Adenovirus ORCA-010: + $ref: + - "_terms_enum.yaml#/oncolytic_adenovirus_orca010/common" + Oncolytic Herpes Simplex Virus-1 ONCR-177: + $ref: + - "_terms_enum.yaml#/oncolytic_herpes_simplex_virus1_oncr177/common" + Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011: + $ref: + - "_terms_enum.yaml#/oncolytic_hsv1_expressing_il12_and_antipd1_antibody_t3011/common" + Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein: + $ref: + - "_terms_enum.yaml#/oncolytic_measles_virus_encoding_helicobacter_pylori_neutrophilactivating_protein/common" + Ontorpacept: + $ref: + - "_terms_enum.yaml#/ontorpacept/common" + Onvatilimab: + $ref: + - "_terms_enum.yaml#/onvatilimab/common" + Opolimogene Capmilisbac: + $ref: + - "_terms_enum.yaml#/opolimogene_capmilisbac/common" + Opucolimab: + $ref: + - "_terms_enum.yaml#/opucolimab/common" + Orelabrutinib: + $ref: + - "_terms_enum.yaml#/orelabrutinib/common" + Orvacabtagene Autoleucel: + $ref: + - "_terms_enum.yaml#/orvacabtagene_autoleucel/common" + Oxaliplatin Eluting Beads: + $ref: + - "_terms_enum.yaml#/oxaliplatin_eluting_beads/common" + p97 Inhibitor CB-5339: + $ref: + - "_terms_enum.yaml#/p97_inhibitor_cb5339/common" + p97 Inhibitor CB-5339 Tosylate: + $ref: + - "_terms_enum.yaml#/p97_inhibitor_cb5339_tosylate/common" + Pacmilimab: + $ref: + - "_terms_enum.yaml#/pacmilimab/common" + Pamrevlumab: + $ref: + - "_terms_enum.yaml#/pamrevlumab/common" + Pan-KRAS Inhibitor BI 1701963: + $ref: + - "_terms_enum.yaml#/pankras_inhibitor_bi_1701963/common" + Pan-mutation-selective EGFR Inhibitor CLN-081: + $ref: + - "_terms_enum.yaml#/panmutationselective_egfr_inhibitor_cln081/common" + Pan-TRK Inhibitor NOV1601: + $ref: + - "_terms_enum.yaml#/pantrk_inhibitor_nov1601/common" + Panulisib: + $ref: + - "_terms_enum.yaml#/panulisib/common" + PARP7 Inhibitor RBN-2397: + $ref: + - "_terms_enum.yaml#/parp7_inhibitor_rbn2397/common" + PARP 1/2 Inhibitor IMP4297: + $ref: + - "_terms_enum.yaml#/parp_12_inhibitor_imp4297/common" + PARP Inhibitor NMS-03305293: + $ref: + - "_terms_enum.yaml#/parp_inhibitor_nms03305293/common" + PARP/Tankyrase Inhibitor 2X-121: + $ref: + - "_terms_enum.yaml#/parptankyrase_inhibitor_2x121/common" + Parsaclisib: + $ref: + - "_terms_enum.yaml#/parsaclisib/common" + Parsaclisib Hydrochloride: + $ref: + - "_terms_enum.yaml#/parsaclisib_hydrochloride/common" + Partially Engineered T-regulatory Cell Donor Graft TRGFT-201: + $ref: + - "_terms_enum.yaml#/partially_engineered_tregulatory_cell_donor_graft_trgft201/common" + Patritumab Deruxtecan: + $ref: + - "_terms_enum.yaml#/patritumab_deruxtecan/common" + Paxalisib: + $ref: + - "_terms_enum.yaml#/paxalisib/common" + PD-L1 Inhibitor GS-4224: + $ref: + - "_terms_enum.yaml#/pdl1_inhibitor_gs4224/common" + PD-L1/4-1BB/HSA Trispecific Fusion Protein NM21-1480: + $ref: + - "_terms_enum.yaml#/pdl141bbhsa_trispecific_fusion_protein_nm211480/common" + Pegvorhyaluronidase Alfa: + $ref: + - "_terms_enum.yaml#/pegvorhyaluronidase_alfa/common" + Pegylated SN-38 Conjugate PLX038: + $ref: + - "_terms_enum.yaml#/pegylated_sn38_conjugate_plx038/common" + Pelabresib: + $ref: + - "_terms_enum.yaml#/pelabresib/common" + Peposertib: + $ref: + - "_terms_enum.yaml#/peposertib/common" + Personalized and Adjusted Neoantigen Peptide Vaccine PANDA-VAC: + $ref: + - "_terms_enum.yaml#/personalized_and_adjusted_neoantigen_peptide_vaccine_pandavac/common" + Personalized Neoantigen DNA Vaccine GNOS-PV01: + $ref: + - "_terms_enum.yaml#/personalized_neoantigen_dna_vaccine_gnospv01/common" + Personalized Neoantigen DNA Vaccine GNOS-PVO2: + $ref: + - "_terms_enum.yaml#/personalized_neoantigen_dna_vaccine_gnospvo2/common" + Photodynamic Compound TLD-1433: + $ref: + - "_terms_enum.yaml#/photodynamic_compound_tld1433/common" + Pimitespib: + $ref: + - "_terms_enum.yaml#/pimitespib/common" + Pimurutamab: + $ref: + - "_terms_enum.yaml#/pimurutamab/common" + Pinatuzumab Vedotin: + $ref: + - "_terms_enum.yaml#/pinatuzumab_vedotin/common" + Pixatimod: + $ref: + - "_terms_enum.yaml#/pixatimod/common" + Plamotamab: + $ref: + - "_terms_enum.yaml#/plamotamab/common" + Plasmid DNA Vaccine pING-hHER3FL: + $ref: + - "_terms_enum.yaml#/plasmid_dna_vaccine_pinghher3fl/common" + pNGVL4a-CRT-E6E7L2 DNA Vaccine: + $ref: + - "_terms_enum.yaml#/pngvl4acrte6e7l2_dna_vaccine/common" + pNGVL4a-Sig/E7(detox)/HSP70 DNA and HPV16 L2/E6/E7 Fusion Protein TA-CIN Vaccine PVX-2: + $ref: + - "_terms_enum.yaml#/pngvl4asige7detoxhsp70_dna_and_hpv16_l2e6e7_fusion_protein_tacin_vaccine_pvx2/common" + Polymer-conjugated IL-15 Receptor Agonist NKTR-255: + $ref: + - "_terms_enum.yaml#/polymerconjugated_il15_receptor_agonist_nktr255/common" + Porcupine Inhibitor XNW7201: + $ref: + - "_terms_enum.yaml#/porcupine_inhibitor_xnw7201/common" + PPAR Alpha Antagonist TPST-1120: + $ref: + - "_terms_enum.yaml#/ppar_alpha_antagonist_tpst1120/common" + Pralsetinib: + $ref: + - "_terms_enum.yaml#/pralsetinib/common" + Praluzatamab Ravtansine: + $ref: + - "_terms_enum.yaml#/praluzatamab_ravtansine/common" + PRMT5 Inhibitor PRT811: + $ref: + - "_terms_enum.yaml#/prmt5_inhibitor_prt811/common" + Prolgolimab: + $ref: + - "_terms_enum.yaml#/prolgolimab/common" + Prostaglandin E2 EP4 Receptor Inhibitor AN0025: + $ref: + - "_terms_enum.yaml#/prostaglandin_e2_ep4_receptor_inhibitor_an0025/common" + Protein Tyrosine Kinase 2 Inhibitor IN10018: + $ref: + - "_terms_enum.yaml#/protein_tyrosine_kinase_2_inhibitor_in10018/common" + Pyruvate Kinase M2 Isoform Activator TP-1454: + $ref: + - "_terms_enum.yaml#/pyruvate_kinase_m2_isoform_activator_tp1454/common" + Racemetyrosine/Methoxsalen/Phenytoin/Sirolimus SM-88: + $ref: + - "_terms_enum.yaml#/racemetyrosinemethoxsalenphenytoinsirolimus_sm88/common" + Radgocitabine: + $ref: + - "_terms_enum.yaml#/radgocitabine/common" + Radgocitabine Hydrochloride: + $ref: + - "_terms_enum.yaml#/radgocitabine_hydrochloride/common" + Ragifilimab: + $ref: + - "_terms_enum.yaml#/ragifilimab/common" + Recombinant Bacterial Minicells VAX014: + $ref: + - "_terms_enum.yaml#/recombinant_bacterial_minicells_vax014/common" + Recombinant Erwinia asparaginase JZP-458: + $ref: + - "_terms_enum.yaml#/recombinant_erwinia_asparaginase_jzp458/common" + Recombinant Human Papillomavirus 11-valent Vaccine: + $ref: + - "_terms_enum.yaml#/recombinant_human_papillomavirus_11valent_vaccine/common" + Recombinant Human TRAIL-Trimer Fusion Protein SCB-313: + $ref: + - "_terms_enum.yaml#/recombinant_human_trailtrimer_fusion_protein_scb313/common" + Recombinant Humanized Anti-HER-2 Bispecific Monoclonal Antibody MBS301: + $ref: + - "_terms_enum.yaml#/recombinant_humanized_antiher2_bispecific_monoclonal_antibody_mbs301/common" + Redaporfin: + $ref: + - "_terms_enum.yaml#/redaporfin/common" + RET/SRC Inhibitor TPX-0046: + $ref: + - "_terms_enum.yaml#/retsrc_inhibitor_tpx0046/common" + Retifanlimab: + $ref: + - "_terms_enum.yaml#/retifanlimab/common" + Revdofilimab: + $ref: + - "_terms_enum.yaml#/revdofilimab/common" + Rezivertinib: + $ref: + - "_terms_enum.yaml#/rezivertinib/common" + Ripertamab: + $ref: + - "_terms_enum.yaml#/ripertamab/common" + Roblitinib: + $ref: + - "_terms_enum.yaml#/roblitinib/common" + ROBO1-targeted BiCAR-NKT Cells: + $ref: + - "_terms_enum.yaml#/robo1targeted_bicarnkt_cells/common" + Rocakinogene Sifuplasmid: + $ref: + - "_terms_enum.yaml#/rocakinogene_sifuplasmid/common" + Roducitabine: + $ref: + - "_terms_enum.yaml#/roducitabine/common" + Rolinsatamab Talirine: + $ref: + - "_terms_enum.yaml#/rolinsatamab_talirine/common" + Roneparstat: + $ref: + - "_terms_enum.yaml#/roneparstat/common" + Ropeginterferon Alfa-2B: + $ref: + - "_terms_enum.yaml#/ropeginterferon_alfa2b/common" + Ropocamptide: + $ref: + - "_terms_enum.yaml#/ropocamptide/common" + Rosopatamab: + $ref: + - "_terms_enum.yaml#/rosopatamab/common" + RSK1-4 Inhibitor PMD-026: + $ref: + - "_terms_enum.yaml#/rsk14_inhibitor_pmd026/common" + Ruthenium-based Small Molecule Therapeutic BOLD-100: + $ref: + - "_terms_enum.yaml#/rutheniumbased_small_molecule_therapeutic_bold100/common" + Ruxotemitide: + $ref: + - "_terms_enum.yaml#/ruxotemitide/common" + Sabatolimab: + $ref: + - "_terms_enum.yaml#/sabatolimab/common" + Samrotamab Vedotin: + $ref: + - "_terms_enum.yaml#/samrotamab_vedotin/common" + Samuraciclib: + $ref: + - "_terms_enum.yaml#/samuraciclib/common" + Sasanlimab: + $ref: + - "_terms_enum.yaml#/sasanlimab/common" + SDF-1 Receptor Antagonist PTX-9908: + $ref: + - "_terms_enum.yaml#/sdf1_receptor_antagonist_ptx9908/common" + Selective Estrogen Receptor Degrader LX-039: + $ref: + - "_terms_enum.yaml#/selective_estrogen_receptor_degrader_lx039/common" + Selective Estrogen Receptor Degrader LY3484356: + $ref: + - "_terms_enum.yaml#/selective_estrogen_receptor_degrader_ly3484356/common" + Serclutamab Talirine: + $ref: + - "_terms_enum.yaml#/serclutamab_talirine/common" + SERD ZN-c5: + $ref: + - "_terms_enum.yaml#/serd_znc5/common" + Serplulimab: + $ref: + - "_terms_enum.yaml#/serplulimab/common" + Shenqi Fuzheng Injection SQ001: + $ref: + - "_terms_enum.yaml#/shenqi_fuzheng_injection_sq001/common" + SHP2 Inhibitor RLY-1971: + $ref: + - "_terms_enum.yaml#/shp2_inhibitor_rly1971/common" + Simlukafusp Alfa: + $ref: + - "_terms_enum.yaml#/simlukafusp_alfa/common" + Simmitinib: + $ref: + - "_terms_enum.yaml#/simmitinib/common" + Simurosertib: + $ref: + - "_terms_enum.yaml#/simurosertib/common" + Siremadlin: + $ref: + - "_terms_enum.yaml#/siremadlin/common" + SIRPa-4-1BBL Fusion Protein DSP107: + $ref: + - "_terms_enum.yaml#/sirpa41bbl_fusion_protein_dsp107/common" + SIRPa-Fc-CD40L Fusion Protein SL-172154: + $ref: + - "_terms_enum.yaml#/sirpafccd40l_fusion_protein_sl172154/common" + Sotigalimab: + $ref: + - "_terms_enum.yaml#/sotigalimab/common" + Sotorasib: + $ref: + - "_terms_enum.yaml#/sotorasib/common" + Spanlecortemlocel: + $ref: + - "_terms_enum.yaml#/spanlecortemlocel/common" + SRPK1/ABCG2 Inhibitor SCO-101: + $ref: + - "_terms_enum.yaml#/srpk1abcg2_inhibitor_sco101/common" + STING Agonist BMS-986301: + $ref: + - "_terms_enum.yaml#/sting_agonist_bms986301/common" + STING Agonist GSK3745417: + $ref: + - "_terms_enum.yaml#/sting_agonist_gsk3745417/common" + STING Agonist IMSA101: + $ref: + - "_terms_enum.yaml#/sting_agonist_imsa101/common" + STING Agonist SB 11285: + $ref: + - "_terms_enum.yaml#/sting_agonist_sb_11285/common" + STING Agonist TAK-676: + $ref: + - "_terms_enum.yaml#/sting_agonist_tak676/common" + STING-expressing E. coli SYNB1891: + $ref: + - "_terms_enum.yaml#/stingexpressing_e_coli_synb1891/common" + Sugemalimab: + $ref: + - "_terms_enum.yaml#/sugemalimab/common" + Superoxide Dismutase Mimetic GC4711: + $ref: + - "_terms_enum.yaml#/superoxide_dismutase_mimetic_gc4711/common" + Synthetic Plumbagin PCUR-101: + $ref: + - "_terms_enum.yaml#/synthetic_plumbagin_pcur101/common" + Tafasitamab: + $ref: + - "_terms_enum.yaml#/tafasitamab/common" + Taletrectinib: + $ref: + - "_terms_enum.yaml#/taletrectinib/common" + Tamrintamab Pamozirine: + $ref: + - "_terms_enum.yaml#/tamrintamab_pamozirine/common" + Tankyrase Inhibitor STP1002: + $ref: + - "_terms_enum.yaml#/tankyrase_inhibitor_stp1002/common" + Tapotoclax: + $ref: + - "_terms_enum.yaml#/tapotoclax/common" + Tasadenoturev: + $ref: + - "_terms_enum.yaml#/tasadenoturev/common" + Tebentafusp: + $ref: + - "_terms_enum.yaml#/tebentafusp/common" + Teclistamab: + $ref: + - "_terms_enum.yaml#/teclistamab/common" + Tefinostat: + $ref: + - "_terms_enum.yaml#/tefinostat/common" + Telaglenastat: + $ref: + - "_terms_enum.yaml#/telaglenastat/common" + Telaglenastat Hydrochloride: + $ref: + - "_terms_enum.yaml#/telaglenastat_hydrochloride/common" + Telisotuzumab: + $ref: + - "_terms_enum.yaml#/telisotuzumab/common" + Tepoditamab: + $ref: + - "_terms_enum.yaml#/tepoditamab/common" + TGF-beta Receptor 1 Kinase Inhibitor SH3051: + $ref: + - "_terms_enum.yaml#/tgfbeta_receptor_1_kinase_inhibitor_sh3051/common" + TGF-beta Receptor 1 Kinase Inhibitor YL-13027: + $ref: + - "_terms_enum.yaml#/tgfbeta_receptor_1_kinase_inhibitor_yl13027/common" + TGFa-PE38 Immunotoxin: + $ref: + - "_terms_enum.yaml#/tgfape38_immunotoxin/common" + Therapeutic Cancer Vaccine ATP128: + $ref: + - "_terms_enum.yaml#/therapeutic_cancer_vaccine_atp128/common" + Thorium Th 227 Anetumab Corixetan: + $ref: + - "_terms_enum.yaml#/thorium_th_227_anetumab_corixetan/common" + Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439: + $ref: + - "_terms_enum.yaml#/thorium_th_227_antiher2_monoclonal_antibody_bay2701439/common" + Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497: + $ref: + - "_terms_enum.yaml#/thorium_th_227_antipsma_monoclonal_antibody_bay_2315497/common" + Thymidylate Synthase Inhibitor CX1106: + $ref: + - "_terms_enum.yaml#/thymidylate_synthase_inhibitor_cx1106/common" + TIGIT Inhibitor M6223: + $ref: + - "_terms_enum.yaml#/tigit_inhibitor_m6223/common" + Tilogotamab: + $ref: + - "_terms_enum.yaml#/tilogotamab/common" + Tiomolibdate Choline: + $ref: + - "_terms_enum.yaml#/tiomolibdate_choline/common" + Tirbanibulin: + $ref: + - "_terms_enum.yaml#/tirbanibulin/common" + TLR7 agonist BNT411: + $ref: + - "_terms_enum.yaml#/tlr7_agonist_bnt411/common" + TLR7 Agonist LHC165: + $ref: + - "_terms_enum.yaml#/tlr7_agonist_lhc165/common" + TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells: + $ref: + - "_terms_enum.yaml#/tm4sf1carepcamcarexpressing_autologous_t_cells/common" + Tolebrutinib: + $ref: + - "_terms_enum.yaml#/tolebrutinib/common" + Topotecan Sustained-release Episcleral Plaque: + $ref: + - "_terms_enum.yaml#/topotecan_sustainedrelease_episcleral_plaque/common" + Transferrin-CRM107: + $ref: + - "_terms_enum.yaml#/transferrincrm107/common" + Trastuzumab Deruxtecan: + $ref: + - "_terms_enum.yaml#/trastuzumab_deruxtecan/common" + Trastuzumab Monomethyl Auristatin F: + $ref: + - "_terms_enum.yaml#/trastuzumab_monomethyl_auristatin_f/common" + Trastuzumab-TLR 7/8 Agonist BDC-1001: + $ref: + - "_terms_enum.yaml#/trastuzumabtlr_78_agonist_bdc1001/common" + Tris-acryl Gelatin Microspheres: + $ref: + - "_terms_enum.yaml#/trisacryl_gelatin_microspheres/common" + TRK Inhibitor TQB3558: + $ref: + - "_terms_enum.yaml#/trk_inhibitor_tqb3558/common" + Troriluzole: + $ref: + - "_terms_enum.yaml#/troriluzole/common" + Tyrosine Kinase Inhibitor TL-895: + $ref: + - "_terms_enum.yaml#/tyrosine_kinase_inhibitor_tl895/common" + Upifitamab: + $ref: + - "_terms_enum.yaml#/upifitamab/common" + Urabrelimab: + $ref: + - "_terms_enum.yaml#/urabrelimab/common" + Ursolic Acid: + $ref: + - "_terms_enum.yaml#/ursolic_acid/common" + Uzansertib: + $ref: + - "_terms_enum.yaml#/uzansertib/common" + Valecobulin: + $ref: + - "_terms_enum.yaml#/valecobulin/common" + Valemetostat: + $ref: + - "_terms_enum.yaml#/valemetostat/common" + Vesencumab: + $ref: + - "_terms_enum.yaml#/vesencumab/common" + Vibecotamab: + $ref: + - "_terms_enum.yaml#/vibecotamab/common" + Vibostolimab: + $ref: + - "_terms_enum.yaml#/vibostolimab/common" + Vorasidenib: + $ref: + - "_terms_enum.yaml#/vorasidenib/common" + Vosilasarm: + $ref: + - "_terms_enum.yaml#/vosilasarm/common" + Vulinacimab: + $ref: + - "_terms_enum.yaml#/vulinacimab/common" + Wee1 Inhibitor ZN-c3: + $ref: + - "_terms_enum.yaml#/wee1_inhibitor_znc3/common" + Wee1 Kinase Inhibitor Debio 0123: + $ref: + - "_terms_enum.yaml#/wee1_kinase_inhibitor_debio_0123/common" + Xevinapant: + $ref: + - "_terms_enum.yaml#/xevinapant/common" + Xiliertinib: + $ref: + - "_terms_enum.yaml#/xiliertinib/common" + Xisomab 3G3: + $ref: + - "_terms_enum.yaml#/xisomab_3g3/common" + Yttrium Y 90 Tabituximab Barzuxetan: + $ref: + - "_terms_enum.yaml#/yttrium_y_90_tabituximab_barzuxetan/common" + Zandelisib: + $ref: + - "_terms_enum.yaml#/zandelisib/common" + Zanidatamab: + $ref: + - "_terms_enum.yaml#/zanidatamab/common" + Zelavespib: + $ref: + - "_terms_enum.yaml#/zelavespib/common" + Zorifertinib: + $ref: + - "_terms_enum.yaml#/zorifertinib/common" + Zotatifin: + $ref: + - "_terms_enum.yaml#/zotatifin/common" + Zotiraciclib Citrate: + $ref: + - "_terms_enum.yaml#/zotiraciclib_citrate/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + therapeutic_level_achieved: + $ref: + - "_terms.yaml#/therapeutic_level_achieved/common" + type: boolean + + therapeutic_levels_achieved: + $ref: + - "_terms.yaml#/therapeutic_levels_achieved/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + therapeutic_target_level: + $ref: + - "_terms.yaml#/therapeutic_target_level/common" + enum: + - '>14 mg/L' + - Unknown + - Not Reported + + timepoint_category: + $ref: + - "_terms.yaml#/timepoint_category/common" + enum: + - Adjuvant Therapy + - Adolescence + - Adulthood + - After Chemotherapy + - After Study Enrollment + - Childhood + - End of Consolidation Therapy + - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 + - First Complete Response + - First Treatment + - Follow-up + - Initial Diagnosis + - Last Contact + - Post Adjuvant Therapy + - Post Hormone Therapy + - Post Initial Treatment + - Post Secondary Therapy + - Postoperative + - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy + - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration + - Prior to Treatment + - Progression + - Recurrence + - Recurrence/Progression + - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment + - Within 3 Months of Surgery + - Other + - Unknown + - Not Reported + + treatment_anatomic_site: + $ref: + - "_terms.yaml#/treatment_anatomic_site/common" + enum: + - Abdomen, total + - Abdominal Wall + - Acetabulum + - Adenoid + - Adipose + - Adrenal + - Alveolar Ridge + - Amniotic Fluid + - Ampulla of Vater + - Anal Sphincter + - Ankle + - Anorectum + - Antecubital Fossa + - Antrum + - Anus + - Aorta + - Aortic Body + - Appendix + - Aqueous Fluid + - Arm + - Artery + - Ascending Colon + - Ascending Colon Hepatic Flexure + - Ascites + - Auditory Canal + - Autonomic Nervous System + - Axilla + - Back + - Bile Duct + - Bladder + - Blood + - Blood Vessel + - Body, total + - Bone + - Bone Marrow + - Bone, non-spine + - Bowel + - Brain + - Brain Stem + - Breast + - Broad Ligament + - Bronchiole + - Bronchus + - Brow + - Buccal Cavity + - Buccal Mucosa + - Buttock + - Calf + - Capillary + - Cardia + - Carina + - Carotid Artery + - Carotid Body + - Cartilage + - Cecum + - Cell-Line + - Central Nervous System + - Cerebellum + - Cerebral Cortex + - Cerebrospinal Fluid + - Cerebrum + - Cervical Spine + - Cervix + - Chest + - Chest Wall + - Chin + - Clavicle + - Clitoris + - Colon + - Colon - Mucosa Only + - Common Duct + - Conjunctiva + - Connective Tissue + - Dermal + - Descending Colon + - Diaphragm + - Distant Site + - Duodenum + - Ear + - Ear Canal + - Ear, Pinna (External) + - Elbow + - Endocrine Gland + - Epididymis + - Epidural Space + - Epitrochlear + - Esophagogastric Junction + - Esophagus + - Esophagus - Mucosa Only + - Eye + - Fallopian Tube + - Femoral Artery + - Femoral Vein + - Femur + - Fibroblasts + - Fibula + - Finger + - Floor of Mouth + - Fluid + - Foot + - Forearm + - Forehead + - Foreskin + - Frontal Cortex + - Frontal Lobe + - Fundus of Stomach + - Gallbladder + - Ganglia + - Gastroesophageal Junction + - Gastrointestinal Tract + - Gastrointestinal, Intestine + - Genitourinary, NOS + - Groin + - Gum + - Hand + - Hard Palate + - Head - Face Or Neck, Nos + - Head and Neck + - Heart + - Hepatic + - Hepatic Duct + - Hepatic Vein + - Hilar + - Hip + - Hippocampus + - Humerus + - Hypopharynx + - Ileocecal Valve + - Ileum + - Ilium + - Index Finger + - Ischium + - Islet Cells + - Jaw + - Jejunum + - Joint + - Kidney + - Knee + - Lacrimal Gland + - Large Bowel + - Laryngopharynx + - Larynx + - Leg + - Leptomeninges + - Ligament + - Lip + - Liver + - Locoregional Site + - Lumbar Spine + - Lung + - Lymph Node + - Lymph Node(s) Axilla + - Lymph Node(s) Cervical + - Lymph Node(s) Distant + - Lymph Node(s) Epitrochlear + - Lymph Node(s) Femoral + - Lymph Node(s) Hilar + - Lymph Node(s) Iliac-Common + - Lymph Node(s) Iliac-External + - Lymph Node(s) Inguinal + - Lymph Node(s) Internal Mammary + - Lymph Node(s) Mammary + - Lymph Node(s) Mediastinal + - Lymph Node(s) Mesenteric + - Lymph Node(s) Occipital + - Lymph Node(s) Paraaortic + - Lymph Node(s) Parotid + - Lymph Node(s) Pelvic + - Lymph Node(s) Popliteal + - Lymph Node(s) Regional + - Lymph Node(s) Retroperitoneal + - Lymph Node(s) Scalene + - Lymph Node(s) Splenic + - Lymph Node(s) Subclavicular + - Lymph Node(s) Submandibular + - Lymph Node(s) Supraclavicular + - Mandible + - Mantle + - Maxilla + - Mediastinal Soft Tissue + - Mediastinum + - Mesentery + - Mesothelium + - Middle Finger + - Mitochondria + - Muscle + - Nails + - Nasal Cavity + - Nasal Soft Tissue + - Nasopharynx + - Neck + - Nerve + - Nerve(s) Cranial + - Occipital Cortex + - Ocular Orbits + - Omentum + - Oral Cavity + - Oral Cavity - Mucosa Only + - Oropharynx + - Ovary + - Palate + - Pancreas + - Parametrium + - Paraspinal Ganglion + - Parathyroid + - Parotid Gland + - Patella + - Pelvis + - Penis + - Pericardium + - Periorbital Soft Tissue + - Peritoneal Cavity + - Peritoneum + - Pharynx + - Pineal + - Pineal Gland + - Pituitary Gland + - Placenta + - Pleura + - Popliteal Fossa + - Pouch + - Primary Tumor Field + - Primary tumor site + - Prostate + - Prostate Bed + - Prostate, Seminal Vesicles and Lymph Nodes + - Pylorus + - Rectosigmoid Junction + - Rectum + - Regional Site + - Retina + - Retro-Orbital Region + - Retroperitoneum + - Rib + - Ring Finger + - Round Ligament + - Sacrum + - Salivary Gland + - Scalp + - Scapula + - Sciatic Nerve + - Scrotum + - Seminal Vesicle + - Shoulder + - Sigmoid Colon + - Sinus + - Sinus(es), Maxillary + - Skeletal Muscle + - Skin + - Skin, lower extremity, local + - Skin, total + - Skin, trunk, local + - Skin, upper extremity, local + - Skull + - Small Bowel + - Small Bowel - Mucosa Only + - Small Finger + - Soft Tissue + - Spinal Column + - Spinal Cord + - Spine + - Spleen + - Splenic Flexure + - Sternum + - Stomach + - Stomach - Mucosa Only + - Subcutaneous Tissue + - Synovium + - Temporal Cortex + - Tendon + - Testis + - Thigh + - Thoracic Spine + - Thorax + - Throat + - Thumb + - Thymus + - Thyroid + - Tibia + - Tongue + - Tonsil + - Tonsil (Pharyngeal) + - Trachea / Major Bronchi + - Transverse Colon + - Trunk + - Umbilical Cord + - Ureter + - Urethra + - Urinary Tract + - Uterus + - Uvula + - Vagina + - Vas Deferens + - Vein + - Venous + - Vertebra + - Vulva + - White Blood Cells + - Wrist + - Other + - Unknown + - Not Reported + enumDef: + Bone Marrow: + $ref: + - "_terms_enum.yaml#/bone_marrow/common" + Buccal Mucosa: + $ref: + - "_terms_enum.yaml#/buccal_mucosa/common" + Cerebrospinal Fluid: + $ref: + - "_terms_enum.yaml#/cerebrospinal_fluid/common" + Connective Tissue: + $ref: + - "_terms_enum.yaml#/connective_tissue/common" + Epitrochlear: + $ref: + - "_terms_enum.yaml#/epitrochlear/common" + Frontal Lobe: + $ref: + - "_terms_enum.yaml#/frontal_lobe/common" + Hilar: + $ref: + - "_terms_enum.yaml#/hilar/common" + Neck: + $ref: + - "_terms_enum.yaml#/neck/common" + Soft Tissue: + $ref: + - "_terms_enum.yaml#/soft_tissue/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_anatomic_sites: + $ref: + - "_terms.yaml#/treatment_anatomic_site/common" + type: array + items: + enum: + - Abdomen, total + - Abdominal Wall + - Acetabulum + - Adenoid + - Adipose + - Adrenal + - Alveolar Ridge + - Amniotic Fluid + - Ampulla of Vater + - Anal Sphincter + - Ankle + - Anorectum + - Antecubital Fossa + - Antrum + - Anus + - Aorta + - Aortic Body + - Appendix + - Aqueous Fluid + - Arm + - Artery + - Ascending Colon + - Ascending Colon Hepatic Flexure + - Ascites + - Auditory Canal + - Autonomic Nervous System + - Axilla + - Back + - Bile Duct + - Bladder + - Blood + - Blood Vessel + - Body, total + - Bone + - Bone Marrow + - Bone, non-spine + - Bowel + - Brain + - Brain Stem + - Breast + - Broad Ligament + - Bronchiole + - Bronchus + - Brow + - Buccal Cavity + - Buccal Mucosa + - Buttock + - Calf + - Capillary + - Cardia + - Carina + - Carotid Artery + - Carotid Body + - Cartilage + - Cecum + - Cell-Line + - Central Nervous System + - Cerebellum + - Cerebral Cortex + - Cerebrospinal Fluid + - Cerebrum + - Cervical Spine + - Cervix + - Chest + - Chest Wall + - Chin + - Clavicle + - Clitoris + - Colon + - Colon - Mucosa Only + - Common Duct + - Conjunctiva + - Connective Tissue + - Dermal + - Descending Colon + - Diaphragm + - Distant Site + - Duodenum + - Ear + - Ear Canal + - Ear, Pinna (External) + - Elbow + - Endocrine Gland + - Epididymis + - Epidural Space + - Epiglottis + - Epitrochlear + - Esophagogastric Junction + - Esophagus + - Esophagus - Mucosa Only + - Eye + - Fallopian Tube + - Femoral Artery + - Femoral Vein + - Femur + - Fibroblasts + - Fibula + - Finger + - Floor of Mouth + - Fluid + - Foot + - Forearm + - Forehead + - Foreskin + - Frontal Cortex + - Frontal Lobe + - Fundus of Stomach + - Gallbladder + - Ganglia + - Gastroesophageal Junction + - Gastrointestinal Tract + - Gastrointestinal, Intestine + - Genitourinary, NOS + - Groin + - Gum + - Hand + - Hard Palate + - Head - Face Or Neck, Nos + - Head and Neck + - Head, Face or Neck, NOS + - Heart + - Hepatic + - Hepatic Duct + - Hepatic Vein + - Hilar + - Hip + - Hippocampus + - Humerus + - Hypopharynx + - Ileocecal Valve + - Ileum + - Ilium + - Index Finger + - Inferior Vena Cava + - Ischium + - Islet Cells + - Jaw + - Jejunum + - Joint + - Kidney + - Knee + - Lacrimal Gland + - Large Bowel + - Laryngopharynx + - Larynx + - Leg + - Leptomeninges + - Ligament + - Lip + - Liver + - Locoregional Site + - Lumbar Spine + - Lung + - Lymph Node + - Lymph Node(s) Axilla + - Lymph Node(s) Cervical + - Lymph Node(s) Distant + - Lymph Node(s) Epitrochlear + - Lymph Node(s) Femoral + - Lymph Node(s) Hilar + - Lymph Node(s) Iliac-Common + - Lymph Node(s) Iliac-External + - Lymph Node(s) Inguinal + - Lymph Node(s) Internal Mammary + - Lymph Node(s) Mammary + - Lymph Node(s) Mediastinal + - Lymph Node(s) Mesenteric + - Lymph Node(s) Occipital + - Lymph Node(s) Paraaortic + - Lymph Node(s) Parotid + - Lymph Node(s) Pelvic + - Lymph Node(s) Popliteal + - Lymph Node(s) Regional + - Lymph Node(s) Retroperitoneal + - Lymph Node(s) Scalene + - Lymph Node(s) Splenic + - Lymph Node(s) Subclavicular + - Lymph Node(s) Submandibular + - Lymph Node(s) Supraclavicular + - Mandible + - Mantle + - Maxilla + - Mediastinal Soft Tissue + - Mediastinum + - Mesentery + - Mesothelium + - Middle Finger + - Mitochondria + - Muscle + - Nails + - Nasal Cavity + - Nasal Soft Tissue + - Nasopharynx + - Neck + - Nerve + - Nerve(s) Cranial + - Occipital Cortex + - Ocular Orbits + - Omentum + - Oral Cavity + - Oral Cavity - Mucosa Only + - Oropharynx + - Ovary + - Palate + - Pancreas + - Parametrium + - Paraspinal Ganglion + - Parathyroid + - Parotid Gland + - Patella + - Pelvis + - Penis + - Pericardium + - Periorbital Soft Tissue + - Peritoneal Cavity + - Peritoneum + - Pharynx + - Pineal + - Pineal Gland + - Pituitary Gland + - Placenta + - Pleura + - Popliteal Fossa + - Pouch + - Primary Tumor Field + - Primary tumor site + - Prostate + - Prostate Bed + - Prostate, Seminal Vesicles and Lymph Nodes + - Pylorus + - Rectosigmoid Junction + - Rectum + - Regional Site + - Retina + - Retro-Orbital Region + - Retroperitoneum + - Rib + - Ring Finger + - Round Ligament + - Sacrum + - Salivary Gland + - Scalp + - Scapula + - Sciatic Nerve + - Scrotum + - Seminal Vesicle + - Shoulder + - Sigmoid Colon + - Sinus + - Sinus(es), Maxillary + - Skeletal Muscle + - Skin + - Skin, lower extremity, local + - Skin, total + - Skin, trunk, local + - Skin, upper extremity, local + - Skull + - Small Bowel + - Small Bowel - Mucosa Only + - Small Finger + - Soft Tissue + - Spinal Column + - Spinal Cord + - Spine + - Spleen + - Splenic Flexure + - Sternum + - Stomach + - Stomach - Mucosa Only + - Subcutaneous Tissue + - Synovium + - Temporal Cortex + - Tendon + - Testis + - Thigh + - Thoracic Spine + - Thorax + - Throat + - Thumb + - Thymus + - Thyroid + - Tibia + - Tongue + - Tonsil + - Tonsil (Pharyngeal) + - Trachea / Major Bronchi + - Transverse Colon + - Trunk + - Umbilical Cord + - Ureter + - Urethra + - Urinary Tract + - Uterus + - Uvula + - Vagina + - Vas Deferens + - Vein + - Venous + - Vertebra + - Vulva + - White Blood Cells + - Wrist + - Other + - Unknown + - Not Reported + deprecated_enum: + - Head - Face Or Neck, Nos + enumDef: + Bone Marrow: + $ref: + - "_terms_enum.yaml#/bone_marrow/common" + Buccal Mucosa: + $ref: + - "_terms_enum.yaml#/buccal_mucosa/common" + Cerebrospinal Fluid: + $ref: + - "_terms_enum.yaml#/cerebrospinal_fluid/common" + Connective Tissue: + $ref: + - "_terms_enum.yaml#/connective_tissue/common" + Epitrochlear: + $ref: + - "_terms_enum.yaml#/epitrochlear/common" + Frontal Lobe: + $ref: + - "_terms_enum.yaml#/frontal_lobe/common" + Hilar: + $ref: + - "_terms_enum.yaml#/hilar/common" + Inferior Vena Cava: + $ref: + - "_terms_enum.yaml#/inferior_vena_cava/common" + Neck: + $ref: + - "_terms_enum.yaml#/neck/common" + Soft Tissue: + $ref: + - "_terms_enum.yaml#/soft_tissue/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_arm: + $ref: + - "_terms.yaml#/treatment_arm/common" + enum: + - A081105 + - A081801 + - E4512 + - EA5142 + + treatment_dose: + $ref: + - "_terms.yaml#/treatment_dose/common" + type: integer + minimum: 0 + + treatment_dose_max: + $ref: + - "_terms.yaml#/treatment_dose_max/common" + type: number + minimum: 0 + + treatment_dose_units: + $ref: + - "_terms.yaml#/treatment_dose_units/common" + enum: + - AUC + - cGy + - g/day + - g/m2 + - Gy + - IU/kg + - IU/mg + - mCi + - mEq + - mg + - mg/day + - mg/dL + - mg/kg + - mg/kg/day + - mg/m2 + - mg/m2/day + - mg/m2/wk + - mg/mL + - mg/wk + - mIU + - mL + - ug + - ug/m2 + - Wafer + - Unknown + - Not Reported + enumDef: + mg: + $ref: + - "_terms_enum.yaml#/mg/common" + + treatment_duration: + $ref: + - "_terms.yaml#/treatment_duration/common" + type: integer + maximum: 32872 + minimum: -32872 + + treatment_effect: + $ref: + - "_terms.yaml#/treatment_effect/common" + enum: + - Complete Necrosis (No Viable Tumor) + - Incomplete Necrosis (Viable Tumor Present) + - No Known Treatment Effect + - No Necrosis + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_effect_indicator: + $ref: + - "_terms.yaml#/treatment_effect_indicator/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + enumDef: + "Yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "No": + $ref: + - "_terms_enum.yaml#/no/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_frequency: + $ref: + - "_terms.yaml#/treatment_frequency/common" + enum: + - Every Hour + - Five Times Daily + - Four Times Daily + - Three Times Daily + - Twice Daily + - Every 24 Hours + - Every Other Day + - Twice Weekly + - Once Weekly + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_intent_type: + $ref: + - "_terms.yaml#/treatment_intent_type/common" + enum: + - Adjuvant + - Androgen Deprivation Therapy (ADT) + - Cancer Control + - Consolidation Therapy + - Cure + - First-Line Therapy + - Induction + - Maintenance Therapy + - Neoadjuvant + - Palliative + - Prevention + - Radiation Boost + - Re-Excision + - Salvage + - Unknown + - Not Reported + enumDef: + Induction: + $ref: + - "_terms_enum.yaml#/induction/treatment/treatment_intent_type" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_or_therapy: + $ref: + - "_terms.yaml#/treatment_or_therapy/common" + enum: + - "yes" + - "no" + - unknown + - not reported + enumDef: + "yes": + $ref: + - "_terms_enum.yaml#/yes/common" + "no": + $ref: + - "_terms_enum.yaml#/no/common" + unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + not reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_outcome: + $ref: + - "_terms.yaml#/treatment_outcome/common" + enum: + - Complete Response + - Mixed Response + - No Measurable Disease + - No Response + - Normalization of Tumor Markers + - Partial Response + - Persistent Disease + - Progressive Disease + - Stable Disease + - Treatment Ongoing + - Treatment Stopped Due to Toxicity + - Very Good Partial Response + - Unknown + - Not Reported + enumDef: + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + + treatment_outcome_duration: + $ref: + - "_terms.yaml#/treatment_outcome_duration/common" + type: integer + maximum: 32872 + minimum: -32872 + + treatment_type: + $ref: + - "_terms.yaml#/treatment_type/common" + enum: + - Ablation or Embolization, NOS + - Ablation, Cryo + - Ablation, Ethanol Injection + - Ablation, Microwave + - Ablation, NOS + - Ablation, Radiofrequency + - Ablation, Radiosurgical + - Ancillary Treatment + - Antiseizure Treatment + - Biopsy, Excisional + - Biopsy, Incisional + - Bisphosphonate Therapy + - Blinded Study, Treatment Unknown + - Brachytherapy, High Dose + - Brachytherapy, Low Dose + - Brachytherapy, NOS + - Chemoembolization + - Chemoprotectant + - Chemotherapy + - Concurrent Chemoradiation + - Cryoablation + - Distal Pancreatectomy + - Embolization + - Ethanol Injection Ablation + - External Beam Radiation + - Hormone Therapy + - Hysterectomy, NOS + - I-131 Radiation Therapy + - Immunotherapy (Including Vaccines) + - Internal Radiation + - Isolated Limb Perfusion (ILP) + - Organ Transplantation + - Peptide Receptor Radionuclide Therapy (PRRT) + - Pharmaceutical Therapy, NOS + - Pleurodesis + - Pleurodesis, NOS + - Pleurodesis, Talc + - Radiation Therapy, NOS + - Radiation, 2D Conventional + - Radiation, 3D Conformal + - Radiation, Combination + - Radiation, Cyberknife + - Radiation, External Beam + - Radiation, Hypofractionated + - Radiation, Implants + - Radiation, Intensity-Modulated Radiotherapy + - Radiation, Internal + - Radiation, Mixed Photon Beam + - Radiation, Photon Beam + - Radiation, Proton Beam + - Radiation, Radioisotope + - Radiation, Stereotactic/Gamma Knife/SRS + - Radiation, Systemic + - Radioactive Iodine Therapy + - Radioembolization + - Radiosensitizing Agent + - Stem Cell Transplantation, Allogeneic + - Stem Cell Transplantation, Autologous + - Stem Cell Transplantation, Double Autologous + - Stem Cell Transplantation, Haploidentical + - Stem Cell Transplantation, Non-Myeloablative + - Stem Cell Transplantation, NOS + - Stem Cell Transplantation, Syngenic + - Stem Cell Treatment + - Stereotactic Radiosurgery + - Steroid Therapy + - Surgery + - Surgery, Minimally Invasive + - Surgery, NOS + - Surgery, Open + - Targeted Molecular Therapy + - Total Pancreatectomy + - Whipple + - Other + - Unknown + - Not Reported + - Not Allowed To Collect + deprecated_enum: + - Cryoablation + - Not Allowed To Collect + - Surgery + enumDef: + Radiation, Hypofractionated: + $ref: + - "_terms_enum.yaml#/radiation_hypofractionated/common" + Radiation, Photon Beam: + $ref: + - "_terms_enum.yaml#/radiation_photon_beam/common" + Other: + $ref: + - "_terms_enum.yaml#/other/common" + Unknown: + $ref: + - "_terms_enum.yaml#/unknown/common" + Not Reported: + $ref: + - "_terms_enum.yaml#/not_reported/common" + Not Allowed To Collect: + $ref: + - "_terms_enum.yaml#/not_allowed_to_collect/common" + + diagnoses: + $ref: "_definitions.yaml#/to_one" diff --git a/server/data_files/GDC/model/_terms.yaml b/server/data_files/GDC/model/_terms.yaml index 7c16ba3..0a42187 100644 --- a/server/data_files/GDC/model/_terms.yaml +++ b/server/data_files/GDC/model/_terms.yaml @@ -175,7 +175,7 @@ aids_risk_factors: common: description: >- The text term used to describe a risk factor of the acquired immunodeficiency - syndrome (AIDS) that the patient either had at time time of the study or experienced + syndrome (AIDS) that the patient either had at the time of the study or experienced in the past. termDef: term: >- @@ -783,7 +783,7 @@ bmi: body_surface_area: common: description: >- - Numeric value used to represent the 2-dimensional extent of the body surface + Numeric value used to represent the two-dimensional extent of the body surface relating height to weight. termDef: term: >- @@ -909,7 +909,7 @@ cdc_hiv_risk_factors: common: description: >- The text term used to describe a risk factor for human immunodeficiency virus, - as described by the Center for Disease Control. + as described by the Centers for Disease Control. termDef: term: >- CDC HIV Risk Factor Text Term @@ -1212,8 +1212,8 @@ columnar_mucosa_present: comorbidities: common: description: >- - The text term used to describe a comorbidity disease, which coexists with the - patient's malignant disease. + The text term used to describe a patient with one or more diseases or conditions, + which coexist with the patient's malignant disease at the same time. termDef: term: >- Index Date To Comorbidity Day Count @@ -1238,7 +1238,7 @@ comorbidity: comorbidity_method_of_diagnosis: common: description: >- - The text term used to describe the method used to diagnose the patient's comorbidity + The text term used to describe the method used to diagnose the patient's comorbid disease. termDef: term: >- @@ -2937,7 +2937,7 @@ imaging_type: immunosuppressive_treatment_type: common: description: >- - The text term used to describe the type of immunosuppresive treatment the patient + The text term used to describe the type of immunosuppressive treatment the patient received. termDef: term: >- @@ -5568,10 +5568,12 @@ size_extraocular_nodule: termDef: term: >- Extraocular Nodule Size - source: - cde_id: - cde_version: - term_url: + source: NCIt + cde_id: C185261 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C185261" + term_id: C185261 + term_version: 24.07e size_selection_range: common: @@ -5950,7 +5952,7 @@ timepoint_category: tissue_collection_type: common: description: >- - The text term used to describe the tyoe of collection used to obtain tissue. + The text term used to describe the type of collection used to obtain tissue. termDef: term: >- Tissue Collection Type @@ -6629,10 +6631,12 @@ undescended_testis_corrected_age: termDef: term: >- Undescended Testis Corrected Age - source: - cde_id: - cde_version: - term_url: + source: NCIt + cde_id: C181721 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C181721" + term_id: C181721 + term_version: 24.07e undescended_testis_corrected_laterality: common: @@ -7298,28 +7302,32 @@ melanoma_known_primary: spindle_cell_percent: common: description: >- - The percent of uveal melanoma arising from the choroid, ciliary body, or the - iris and characterized by the presence of spindle-shaped melanocytes. + A quantitative measurement of the percent of spindle-shaped melanocytes compared + to the number of total cells present in a sample. termDef: term: >- - Cell Morphology Percent Uveal Spindle Cell Melanoma Integer - source: caDSR - cde_id: 7292254 - cde_version: 1.0 - term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=7292254%20and%20ver_nr=1.0" + Percent of Spindle-Shaped Melanocytes + source: NCIt + cde_id: C200472 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C200472" + term_id: C200472 + term_version: 24.07e epithelioid_cell_percent: common: description: >- - The percent of uveal melanoma characterized by the presence of malignant large - epithelioid melanocytes. + A quantitative measurement of the percent of epithelioid melanocytes compared + to the number of total cells present in a sample. termDef: term: >- - Cell Morphology Percent Uveal Epithelioid Cell Melanoma Integer - source: caDSR - cde_id: 7292253 - cde_version: 1.0 - term_url: "https://cadsr.cancer.gov/onedata/dmdirect/NIH/NCI/CO/CDEDD?filter=CDEDD.ITEM_ID=7292253%20and%20ver_nr=1.0" + Percent of Epithelioid Melanocytes + source: NCIt + cde_id: C200471 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C200471" + term_id: C200471 + term_version: 24.07e tumor_shape: common: @@ -7424,8 +7432,8 @@ myasthenia_gravis_classification: description: >- A finding associated with a patient with myasthenia gravis that is based on the classification system developed by the Myasthenia Gravis Foundation of America - (MGFA) for grading myasthenia gravis that divides the disease into 5 main classes - and several subclasses. + (MGFA) for grading myasthenia gravis that divides the disease into five main + classes and several subclasses. termDef: term: >- Myasthenia Gravis Foundation of America Class @@ -7523,10 +7531,12 @@ genome_doubling: termDef: term: >- Genome Doubling Events - source: - cde_id: - cde_version: - term_url: + source: NCIt + cde_id: C206453 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206453" + term_id: C206453 + term_version: 24.07e cancer_dna_fraction: common: @@ -7535,10 +7545,12 @@ cancer_dna_fraction: termDef: term: >- Cancer DNA Fraction - source: - cde_id: - cde_version: - term_url: + source: NCIt + cde_id: C206454 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206454" + term_id: C206454 + term_version: 24.07e subclonal_genome_fraction: common: @@ -7547,10 +7559,12 @@ subclonal_genome_fraction: termDef: term: >- Subclonal DNA Fraction - source: - cde_id: - cde_version: - term_url: + source: NCIt + cde_id: C206455 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206455" + term_id: C206455 + term_version: 24.07e curated_model_index: common: @@ -7559,10 +7573,12 @@ curated_model_index: termDef: term: >- Curated Model Index - source: - cde_id: - cde_version: - term_url: + source: NCIt + cde_id: C206456 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206456" + term_id: C206456 + term_version: 24.07e workflow_link: common: @@ -7611,10 +7627,12 @@ prescribed_dose_units: termDef: term: >- Prescribed Dose Units - source: - cde_id: - cde_version: - term_url: + source: NCIt + cde_id: C206478 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206478" + term_id: C206478 + term_version: 24.07e number_of_pregnancies: common: @@ -7700,7 +7718,92 @@ hormonal_replacement_therapy_status: termDef: term: >- Hormone Replacement Therapy Status + source: NCIt + cde_id: C206479 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C206479" + term_id: C206479 + term_version: 24.07e + +population_group: + common: + description: >- + A group of individuals united by a common factor (e.g., geographic location, + ethnicity, disease, age, gender). + termDef: + term: >- + Population Group + source: NCIt + cde_id: C17005 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C17005" + term_id: C17005 + term_version: 24.07e + +ajcc_serum_tumor_markers: + common: + description: >- + A laboratory test result in which markers for testicular cancer are tested in + a blood sample for staging purposes. + termDef: + term: >- + Testicular Cancer Serum Markers Test Result + source: NCIt + cde_id: C111067 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C111067" + term_id: C111067 + term_version: 24.07e + +histologic_progression: + common: + description: >- + The evolution of a low-grade neoplastic pathologic process to a high grade malignancy. + termDef: + term: >- + Histologic Progression + source: NCIt + cde_id: C99318 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99318" + term_id: C99318 + term_version: 24.07e + +tumor_basal_diameter: + common: + description: >- + Numeric value in millimeters for the lowest layer of a tumor. + termDef: + term: >- + Tumor Basal Diameter source: cde_id: cde_version: term_url: + +intratubular_germ_cell_neoplasia_present: + common: + description: >- + Text term to indicate whether the intratubular germ cell neoplasm is present + or absent. + termDef: + term: >- + Testicular Intratubular Germ Cell Neoplasia Indicator + source: + cde_id: + cde_version: + term_url: + +pretreatment: + common: + description: >- + Any relevant actions that were performed or occurred prior to a specific treatment. + termDef: + term: >- + Pretreatment + source: NCIt + cde_id: C103339 + cde_version: 24.07e + term_url: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C103339" + term_id: C103339 + term_version: 24.07e diff --git a/server/data_files/GDC/model/demographic.yaml b/server/data_files/GDC/model/demographic.yaml index 950f787..4d82ad8 100644 --- a/server/data_files/GDC/model/demographic.yaml +++ b/server/data_files/GDC/model/demographic.yaml @@ -2153,6 +2153,12 @@ properties: maximum: 89 minimum: 0 + population_group: + $ref: + - "_terms.yaml#/population_group/common" + enum: + - Ashkenazi Jew + premature_at_birth: $ref: - "_terms.yaml#/premature_at_birth/common" diff --git a/server/data_files/GDC/model/diagnosis.yaml b/server/data_files/GDC/model/diagnosis.yaml index fd9591b..79c2cfc 100644 --- a/server/data_files/GDC/model/diagnosis.yaml +++ b/server/data_files/GDC/model/diagnosis.yaml @@ -1025,6 +1025,18 @@ properties: $ref: - "_terms_enum.yaml#/not_allowed_to_collect/common" + ajcc_serum_tumor_markers: + $ref: + - "_terms.yaml#/ajcc_serum_tumor_markers/common" + enum: + - S0 + - S1 + - S2 + - S3 + - SX + - Unknown + - Not Reported + ajcc_staging_system_edition: $ref: - "_terms.yaml#/ajcc_staging_system_edition/common" @@ -1335,8 +1347,8 @@ properties: enum: - Favorable - Intermediate/Normal - - Poor - N/A + - Poor - Unknown - Not Reported @@ -2995,6 +3007,7 @@ properties: - Incisional Biopsy - Laparoscopy - Laparotomy + - Orchiectomy - Pap Smear - Pathologic Review - Physical Exam @@ -7578,6 +7591,7 @@ properties: - Adenocarcinoma in situ, NOS - Adenocarcinoma in tubolovillous adenoma - Adenocarcinoma in tubular adenoma + - Adenocarcinoma in tubulovillous adenoma - Adenocarcinoma in villous adenoma - Adenocarcinoma of anal ducts - Adenocarcinoma of anal glands @@ -9232,6 +9246,7 @@ properties: - Myoma - Myosarcoma - Myxofibroma, NOS + - Myxofibrosarcoma - Myxoid chondrosarcoma - Myxoid fibroma - Myxoid leiomyosarcoma @@ -10109,6 +10124,8 @@ properties: - Yolk sac tumor - Unknown - Not Reported + deprecated_enum: + - Adenocarcinoma in tubolovillous adenoma enumDef: Abdominal desmoid: $ref: @@ -12807,9 +12824,6 @@ properties: Haemangiosarcoma: $ref: - "_terms_enum.yaml#/haemangiosarcoma/common" - Hairy cell leukaemia variant: - $ref: - - "_terms_enum.yaml#/hairy_cell_leukaemia_variant/common" Hairy cell leukemia: $ref: - "_terms_enum.yaml#/hairy_cell_leukemia/common" @@ -18248,7 +18262,15 @@ properties: - Brain, Parietal - Brain, Temporal lobe - Brain, Ventricle, NOS + - Breast, Left Lower Inner + - Breast, Left Lower Outer + - Breast, Left Upper Inner + - Breast, Left Upper Outer - Breast, NOS + - Breast, Right Lower Inner + - Breast, Right Lower Outer + - Breast, Right Upper Inner + - Breast, Right Upper Outer - Bronchus - Buccal mucosa - Central Lung @@ -18270,6 +18292,9 @@ properties: - Esophagus, NOS - Esophagus, Upper Third - Eye + - Eye, Choroid + - Eye, Ciliary Body + - Eye, Iris - Fallopian Tube, Left - Fallopian Tube, NOS - Fallopian Tube, Right @@ -18280,6 +18305,7 @@ properties: - Groin - Head, Face or Neck, NOS - Heart + - Hilar Fat - Inferior Vena Cava - Kidney, Lower Pole - Kidney, Middle @@ -18351,14 +18377,21 @@ properties: - Prostate - Rectum - Renal Vein + - Rete Testis - Retroperitoneum - Salivary gland - Scalp + - Scrotum - Sigmoid colon - Sinus - Skin + - Skin, Extremities + - Skin, Groin + - Skin, Head and Neck + - Skin, Trunk - Small intestine - Soft tissue + - Spermatic Cord - Spinal Cord - Spleen - Stomach @@ -18371,6 +18404,8 @@ properties: - Trachea - Transplanted kidney - Transverse colon + - Tunica Albuginea + - Tunica Vaginalis - Upper lobe, lung - Urethra - Uterus diff --git a/server/data_files/GDC/model/follow_up.yaml b/server/data_files/GDC/model/follow_up.yaml index 96a5bc6..86c8d58 100644 --- a/server/data_files/GDC/model/follow_up.yaml +++ b/server/data_files/GDC/model/follow_up.yaml @@ -1595,8 +1595,11 @@ properties: $ref: - "_terms.yaml#/evidence_of_progression_type/common" enum: + - Biopsy with Histologic Confirmation - Convincing Image Source - Histologic Confirmation + - Physical Examination + - Positive Biomarker(s) - Unknown - Not Reported @@ -1724,6 +1727,15 @@ properties: $ref: - "_terms_enum.yaml#/not_reported/common" + histologic_progression: + $ref: + - "_terms.yaml#/histologic_progression/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + history_of_tumor: $ref: - "_terms.yaml#/history_of_tumor/common" @@ -1894,6 +1906,7 @@ properties: items: enum: - Abdomen + - Cervix Uteri - Lymph Node - Pelvis - Pleura @@ -1908,9 +1921,11 @@ properties: $ref: - "_terms.yaml#/imaging_findings/common" enum: + - Bladder Involvement - Carcinomatosis - Distant Metastasis - Equivocal + - Extra-Pelvic Metastatic Disease - Extraprostatic Extension, Localized - Extraprostatic Extension, Regional Lymphadenopathy - Kidney Involvement @@ -1918,7 +1933,11 @@ properties: - Lung Involvement - No Evidence of Extraprostatic Extension - Normal + - Paraaortic Lymph Node Involvement + - Parametrium Involvement + - Pelvic Lymph Node Involvement - Retroperitoneal Lymph Node Involvement + - Supraclavicular Lymph Node Involvement - Vena Cava Involvement/Thrombus - Unknown - Not Reported @@ -2979,19 +2998,35 @@ properties: - Adjuvant Therapy - Adolescence - Adulthood + - After Chemotherapy + - After Study Enrollment - Childhood + - End of Consolidation Therapy + - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 + - First Complete Response + - First Treatment - Follow-up - Initial Diagnosis - Last Contact - Post Adjuvant Therapy - Post Hormone Therapy + - Post Initial Treatment - Post Secondary Therapy - Postoperative - Preoperative - Prior to Adjuvant Therapy + - Prior to Chemotherapy - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration - Prior to Treatment + - Progression + - Recurrence - Recurrence/Progression + - Sample Procurement - Within 2 Months After Completion of First-Course Treatment - Within 3 Months of Surgery - Other diff --git a/server/data_files/GDC/model/molecular_test.yaml b/server/data_files/GDC/model/molecular_test.yaml index 65b153f..63cf143 100644 --- a/server/data_files/GDC/model/molecular_test.yaml +++ b/server/data_files/GDC/model/molecular_test.yaml @@ -3596,8 +3596,10 @@ properties: - HPV56 - HPV58 - HPV59 + - HPV63 - HPV66 - HPV68 + - HPV70 - HPV73 - Unknown - Not Reported @@ -7313,6 +7315,8 @@ properties: - 26-50 - 51-75 - 76-100 + - 1-4% + - 5-9% - <10% - 10-19% - 20-29% @@ -7342,13 +7346,41 @@ properties: $ref: - "_terms.yaml#/timepoint_category/common" enum: + - Adjuvant Therapy + - Adolescence + - Adulthood + - After Chemotherapy + - After Study Enrollment + - Childhood - End of Consolidation Therapy + - End of Treatment Course - End of Treatment Course 1 - End of Treatment Course 2 + - First Complete Response + - First Treatment + - Follow-up - Initial Diagnosis + - Last Contact + - Post Adjuvant Therapy + - Post Hormone Therapy + - Post Initial Treatment + - Post Secondary Therapy + - Postoperative - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy + - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration - Prior to Treatment + - Progression + - Recurrence + - Recurrence/Progression - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment + - Within 3 Months of Surgery + - Other - Unknown - Not Reported enumDef: diff --git a/server/data_files/GDC/model/other_clinical_attribute.yaml b/server/data_files/GDC/model/other_clinical_attribute.yaml index a6196ee..c685d9f 100644 --- a/server/data_files/GDC/model/other_clinical_attribute.yaml +++ b/server/data_files/GDC/model/other_clinical_attribute.yaml @@ -50,6 +50,7 @@ uniqueKeys: deprecated: - pregnancy_count - viral_hepatitis_serologies + - undescended_testis_corrected_age properties: @@ -135,9 +136,30 @@ properties: - Acute Renal Failure - Adenocarcinoma - Adenomatous Polyposis Coli + - Adenomyosis + - Adenosis (Atypical Adenomatous Hyperplasia) - Adrenocortical Insufficiency + - Alcoholic Liver Disease - Allergies + - Allergy, Animal, NOS + - Allergy, Ant + - Allergy, Bee + - Allergy, Cat + - Allergy, Dairy or Lactose + - Allergy, Dog + - Allergy, Eggs + - Allergy, Food, NOS + - Allergy, Fruit + - Allergy, Meat + - Allergy, Mold or Dust + - Allergy, Nuts + - Allergy, Processed Foods + - Allergy, Seafood + - Allergy, Wasp - Alpha-1 Antitrypsin + - Alpha-1 Antitrypsin Deficiency + - Altered Mental Status + - Androgen Excess - Anemia - Anxiety - Arrhythmia @@ -145,15 +167,20 @@ properties: - Asthma - Ataxia-Telangiectasia - Atrial Fibrillation + - Autoimmune Atrophic Chronic Gastritis - Autoimmune Lymphoproliferative Syndrome (ALPS) - Avascular Necrosis - Bacteroides fragilis + - BAP1 Tumor Predisposition Syndrome - Barrett's Esophagus - Basal Cell Carcinoma - Beckwith-Wiedemann - Behcet's Disease + - Benign Prostatic Hyperplasia - Benign Thyroid Nodule - Biliary Disorder + - Birt-Hogg-Dube Syndrome + - BK Virus - Blood Clots - Bone Fracture(s) - Bronchitis @@ -166,6 +193,7 @@ properties: - Chloroma - Cholelithiasis - Chronic Fatigue Syndrome + - Chronic Kidney Disease - Chronic Pancreatitis - Chronic Renal Failure - Chronic Systemic Steroid Use @@ -174,41 +202,59 @@ properties: - Clonal Hematopoiesis - CNS Infection - Colon Polyps + - Colonization, Bacterial + - Colonization, Fungal + - Common Variable Immune Deficiency (CVID) - Common Variable Immunodeficiency - Congestive Heart Failure (CHF) - Connective Tissue Disorder - COPD - Coronary Artery Disease + - Cortisol Excess + - Cowden Syndrome - Crohn's Disease - Cryptococcal Meningitis - Cryptogenic Organizing Pneumonia + - Cyst(s) - Cytomegalovirus (CMV) - Deep Vein Thrombosis / Thromboembolism + - Dementia - Denys-Drash Syndrome - Depression - Dermatomyosis - Diabetes + - Diabetes, NOS + - Diabetes, Type I - Diabetes, Type II - Diabetic Neuropathy - Diet Controlled Diabetes - Diverticulitis + - Diverticulosis - Down Syndrome - DVT/PE - Dyslipidemia - EBV Lymphoproliferation - Eczema + - Endometriosis + - Endosalpingiosis - Epilepsy + - Epithelial Dysplasia + - Epithelial Hyperplasia - Epstein-Barr Virus - Escherichia coli + - Estrogen Excess - Familial Adenomatous Polyposis - Fanconi Anemia - Fibromyalgia - Fibrosis - Follicular Adenoma + - Gastric Polyp(s) - Gastritis - Gastroesophageal Reflux Disease - GERD + - Gilbert's Syndrome - Glaucoma + - Glomerular Disease - Glycogen Storage Disease - Goiter - Gonadal Dysfunction @@ -216,22 +262,40 @@ properties: - Gout - Graves' Disease - Hashimoto's Thyroiditis + - Hay Fever - Headache - Heart Disease - Helicobacter pylori Infection + - Helicobacter pylori-Associated Gastritis + - Hematologic Disorder, NOS - Hemihypertrophy + - Hemochromatosis - Hemorrhagic Cystitis + - Hepatic Encephalopathy - Hepatitis - Hepatitis A Infection - Hepatitis B Infection - Hepatitis C Infection - Hepatitis, Chronic + - Hepatitis, NOS + - Hereditary Breast Cancer + - Hereditary Hemorrhagic Telangiectasia + - Hereditary Kidney Oncocytoma + - Hereditary Leiomyomatosis and Renal Cell Carcinoma - Hereditary Non-Polyposis Colon Cancer + - Hereditary Ovarian Cancer + - Hereditary Papillary Renal Cell Carcinoma + - Hereditary Prostate Cancer + - Hereditary Renal Cell Carcinoma - Herpes - Herpes Zoster + - High Grade Dysplasia - High Grade Liver Dysplastic Nodule + - High-grade Prostatic Intraepithelial Neoplasia (PIN) - HIV/AIDS - Hodgkin Lymphoma + - Human Herpesvirus-6 (HHV-6) + - Human Herpesvirus-8 (HHV-8) - Human Papillomavirus Infection - HUS/TTP - Hypercalcemia @@ -243,9 +307,13 @@ properties: - Hyperthyroidism - Hypospadias - Hypothyroidism + - Inflammation + - Inflammation, Hyperkeratosis - Inflammatory Bowel Disease + - Inherited Genetic Syndrome, NOS - Insulin Controlled Diabetes - Interstitial Pneumonitis or ARDS + - Intestinal Metaplasia - Intraductal Papillary Mucinous Neoplasm - Iron Overload - Ischemic Heart Disease @@ -255,6 +323,7 @@ properties: - Li-Fraumeni Syndrome - Liver Cirrhosis (Liver Disease) - Liver Toxicity (Non-Infectious) + - Low Grade Dysplasia - Low Grade Liver Dysplastic Nodule - Lupus - Lymphamatoid Papulosis @@ -266,11 +335,18 @@ properties: - Malaria - Metabolic Syndrome - Methicillin-Resistant Staphylococcus aureus (MRSA) + - Mineralcorticoids Excess + - Motor / Movement Change - Myasthenia Gravis - Mycobacterium avium Complex + - Myelodysplastic Syndrome - Myocardial Infarction + - Neurocystericerosis - Neuroendocrine Tumor + - Nevus of Ota - Nodular Hyperplasia + - Nodular Prostatic Hyperplasia + - Nonalcoholic Fatty Liver Disease - Nonalcoholic Steatohepatitis - Obesity - Organ Transplant (Site) @@ -281,6 +357,8 @@ properties: - Other Pulmonary Complications - Pain (Various) - Pancreatitis + - Parasitic Disease of Biliary Tract + - Parkinson's Disease - Peptic Ulcer (Ulcer) - Peripheral Neuropathy - Peripheral Vascular Disease @@ -293,36 +371,63 @@ properties: - Psoriasis - Pulmonary Fibrosis - Pulmonary Hemorrhage + - Recurrent Pyogenic Cholangitis - Renal Dialysis - Renal Failure (Requiring Dialysis) - Renal Insufficiency - Rheumatoid Arthritis - Rheumatologic Disease + - Rubella - Rubinstein-Taybi Syndrome - Sarcoidosis + - Scarlet Fever - Seizure + - Sensory Changes + - Serous Tubal Intraepithelial Carcinoma (STIC) - Shingles + - Sialadenitis - Sjogren's Syndrome + - Skin Rash - Sleep Apnea - Smoking + - Squamous Metaplasia - Staph Osteomyelitis - Staphylococcus aureus - Steatosis - Stroke + - Succinate Dehydrogenase-Deficient Renal Cell Carcinoma - Syphilis - Thyroid Disease, Non-Cancer + - Thyroid Nodular Hyperplasia + - Tobacco, NOS + - Tobacco, Smokeless + - Tobacco, Smoking - Transient Ischemic Attack - Treponema pallidum - Tuberculosis + - Tuberous Sclerosis + - Tubulointerstitial Disease + - Tumor-Associated Lymphoid Proliferation - Turcot Syndrome - Tyrosinemia - Ulcerative Colitis + - Undescended Testis - Urinary Tract Infection - Varicella Zoster Virus + - Vascular Disease + - Vision Changes + - Von Hippel-Lindau Syndrome - Wagr Syndrome - Other - Unknown - Not Reported + deprecated_enum: + - Alpha-1 Antitrypsin + - Diabetes + - Gastroesophageal Reflux Disease + - Hepatitis + - Kidney Disease + - Smoking enumDef: Cancer: $ref: @@ -725,6 +830,7 @@ properties: $ref: - "_terms.yaml#/number_of_pregnancies/common" enum: + - "0" - "1" - "2" - "3" @@ -914,10 +1020,13 @@ properties: items: enum: - Abnormal Glucose Level + - Adenocarcinoma + - Adenomatous Polyposis Coli - Adenomyosis - Adenosis (Atypical Adenomatous Hyperplasia) - Alcohol Consumption - Alcoholic Liver Disease + - Allergies - Allergy, Animal, NOS - Allergy, Ant - Allergy, Bee @@ -937,37 +1046,56 @@ properties: - Altered Mental Status - Androgen Excess - Anemia + - Arthritis - Asthma - Ataxia-Telangiectasia + - Atrial Fibrillation - Autoimmune Atrophic Chronic Gastritis - Autoimmune Lymphoproliferative Syndrome (ALPS) - Bacteroides fragilis - BAP1 Tumor Predisposition Syndrome - Barrett's Esophagus + - Basal Cell Carcinoma - Beckwith-Wiedemann - Behcet's Disease - Benign Prostatic Hyperplasia - Benign Thyroid Nodule + - Biliary Disorder - Birt-Hogg-Dube Syndrome - BK Virus - BRCA Family History + - Bronchitis + - Calcium Channel Blockers - Cancer + - Cataracts + - Celiac Disease + - Cerebrovascular Disease - Chlamydia - Chloroma - Cholelithiasis + - Chronic Fatigue Syndrome - Chronic Hepatitis - Chronic Kidney Disease - Chronic Pancreatitis - Chronic Systemic Steroid Use - Chronic Thyroiditis - Cirrhosis + - Clonal Hematopoiesis + - CNS Infection - Colon Polyps - Colonization, Bacterial - Colonization, Fungal - Common Variable Immune Deficiency (CVID) + - Common Variable Immunodeficiency + - Congestive Heart Failure (CHF) + - Connective Tissue Disorder + - COPD + - Coronary Artery Disease - Cortisol Excess - Cowden Syndrome + - Crohn's Disease - Cryptococcal Meningitis + - Cryptogenic Organizing Pneumonia - Cyst(s) - Cytomegalovirus (CMV) - Denys-Drash Syndrome @@ -979,6 +1107,7 @@ properties: - Diverticulitis - Diverticulosis - Down Syndrome + - Dyslipidemia - EBV Lymphoproliferation - Eczema - Endometriosis @@ -994,14 +1123,19 @@ properties: - Follicular Adenoma - Gastric Polyp(s) - Gastritis + - GERD - Gilbert's Syndrome + - Glaucoma - Glomerular Disease + - Glycogen Storage Disease - Goiter - Gorlin Syndrome + - Gout - Graves' Disease - Hashimoto's Thyroiditis - Hay Fever - Headache + - Heart Disease - Helicobacter pylori Infection - Helicobacter pylori-Associated Gastritis - Hematologic Disorder, NOS @@ -1011,24 +1145,32 @@ properties: - Hepatitis A Infection - Hepatitis B Infection - Hepatitis C Infection + - Hepatitis, Chronic - Hepatitis, NOS - Hereditary Breast Cancer - Hereditary Hemorrhagic Telangiectasia - Hereditary Kidney Oncocytoma - Hereditary Leiomyomatosis and Renal Cell Carcinoma + - Hereditary Non-Polyposis Colon Cancer - Hereditary Ovarian Cancer - Hereditary Papillary Renal Cell Carcinoma - Hereditary Prostate Cancer - Hereditary Renal Cell Carcinoma + - Herpes + - Herpes Simplex Virus - Herpes Zoster - High Grade Dysplasia + - High Grade Liver Dysplastic Nodule - High-grade Prostatic Intraepithelial Neoplasia (PIN) - HIV + - HIV/AIDS - Hodgkin Lymphoma - Human Herpesvirus-6 (HHV-6) - Human Herpesvirus-8 (HHV-8) - Human Papillomavirus Infection - Hypercholesterolemia + - Hyperglycemia + - Hyperlipidemia - Hyperparathyroidism - Hypertension - Hyperthyroidism @@ -1036,11 +1178,19 @@ properties: - Hypothyroidism - Inflammation - Inflammation, Hyperkeratosis + - Inflammatory Bowel Disease - Inherited Genetic Syndrome, NOS + - Interstitial Pneumonitis or ARDS - Intestinal Metaplasia + - Intraductal Papillary Mucinous Neoplasm - Iron Overload + - Ischemic Heart Disease + - ITP - Li-Fraumeni Syndrome + - Liver Cirrhosis (Liver Disease) - Low Grade Dysplasia + - Low Grade Liver Dysplastic Nodule + - Lupus - Lymphamatoid Papulosis - Lymphocytic Meningitis - Lymphocytic Thyroiditis @@ -1053,7 +1203,10 @@ properties: - Myasthenia Gravis - Mycobacterium avium Complex - Myelodysplastic Syndrome + - Myocardial Infarction - Neurocystericerosis + - Neuroendocrine Tumor + - Nevus of Ota - Nodular Hyperplasia - Nodular Prostatic Hyperplasia - Nonalcoholic Fatty Liver Disease @@ -1061,15 +1214,26 @@ properties: - None - Obesity - Oral Contraceptives + - Organ Transplant (Site) + - Osteoarthritis - Pancreatitis - Parasitic Disease of Biliary Tract + - Peptic Ulcer (Ulcer) + - Peripheral Vascular Disease + - Peutz-Jeghers Disease - Pneumocystis Pneumonia - Pneumonia, NOS - Polycystic Ovarian Syndrome (PCOS) + - Pregnancy in Patient or Partner - Primary Sclerosing Cholangitis + - Psoriasis + - Pulmonary Fibrosis - Recurrent Pyogenic Cholangitis - Reflux Disease + - Renal Failure (Requiring Dialysis) + - Renal Insufficiency - Rheumatoid Arthritis + - Rheumatologic Disease - Rubella - Rubinstein-Taybi Syndrome - Sarcoidosis @@ -1081,12 +1245,15 @@ properties: - Sialadenitis - Sjogren's Syndrome - Skin Rash + - Sleep Apnea - Squamous Metaplasia + - Staph Osteomyelitis - Staphylococcus aureus - Steatosis - Succinate Dehydrogenase-Deficient Renal Cell Carcinoma - Syphilis - Tattoo + - Thyroid Disease, Non-Cancer - Thyroid Nodular Hyperplasia - Tobacco, NOS - Tobacco, Smokeless @@ -1097,8 +1264,10 @@ properties: - Tubulointerstitial Disease - Tumor-associated Lymphoid Proliferation - Turcot Syndrome + - Tyrosinemia - Ulcerative Colitis - Undescended Testis + - Urinary Tract Infection - Varicella Zoster Virus - Vascular Disease - Vision Changes @@ -1106,6 +1275,11 @@ properties: - Wagr Syndrome - Unknown - Not Reported + deprecated_enum: + - Chronic Hepatitis + - Cirrhosis + - HIV + - Reflux Disease enumDef: Cancer: $ref: @@ -1127,19 +1301,36 @@ properties: - Adjuvant Therapy - Adolescence - Adulthood + - After Chemotherapy + - After Study Enrollment - Childhood + - End of Consolidation Therapy + - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 + - First Complete Response + - First Treatment - Follow-up - Initial Diagnosis - Last Contact - Post Adjuvant Therapy - Post Hormone Therapy + - Post Initial Treatment - Post Secondary Therapy - Postoperative - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration - Prior to Treatment + - Progression + - Recurrence - Recurrence/Progression - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment - Within 3 Months of Surgery - Other - Unknown @@ -1204,6 +1395,17 @@ properties: maximum: 89 minimum: 0 + undescended_testis_corrected_age_range: + $ref: + - "_terms.yaml#/undescended_testis_corrected_age/common" + enum: + - 2-11 months + - 1-2 years + - 3-9 years + - 10-14 years + - Unknown + - Not Reported + undescended_testis_corrected_laterality: $ref: - "_terms.yaml#/undescended_testis_corrected_laterality/common" diff --git a/server/data_files/GDC/model/pathology_detail.yaml b/server/data_files/GDC/model/pathology_detail.yaml index fb3d2c5..877d9eb 100644 --- a/server/data_files/GDC/model/pathology_detail.yaml +++ b/server/data_files/GDC/model/pathology_detail.yaml @@ -38,6 +38,12 @@ uniqueKeys: - [id] - [project_id, submitter_id] +deprecated: + - epithelioid_cell_percent + - extrascleral_extension + - size_extraocular_nodule + - spindle_cell_percent + properties: $ref: @@ -326,6 +332,18 @@ properties: maximum: 100 minimum: 0 + epithelioid_cell_percent_range: + $ref: + - "_terms.yaml#/epithelioid_cell_percent/common" + enum: + - 0% + - 1-30% + - 31-60% + - 61-90% + - '>90%' + - Unknown + - Not Reported + extracapsular_extension: $ref: - "_terms.yaml#/extracapsular_extension/common" @@ -362,11 +380,29 @@ properties: - Unknown - Not Reported + extraocular_nodule_size: + $ref: + - "_terms.yaml#/size_extraocular_nodule/common" + enum: + - <=5mm + - '>5mm' + - Unknown + - Not Reported + extrascleral_extension: $ref: - "_terms.yaml#/extrascleral_extension/common" type: boolean + extrascleral_extension_present: + $ref: + - "_terms.yaml#/extrascleral_extension/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + extrathyroid_extension: $ref: - "_terms.yaml#/extrathyroid_extension/common" @@ -425,6 +461,15 @@ properties: $ref: - "_terms_enum.yaml#/not_reported/common" + intratubular_germ_cell_neoplasia_present: + $ref: + - "_terms.yaml#/intratubular_germ_cell_neoplasia_present/common" + enum: + - "Yes" + - "No" + - Unknown + - Not Reported + largest_extrapelvic_peritoneal_focus: $ref: - "_terms.yaml#/largest_extrapelvic_peritoneal_focus/common" @@ -463,6 +508,7 @@ properties: - Neck, Left - Neck, NOS - Neck, Right + - Retroperitoneal - Unknown - Not Reported @@ -483,6 +529,7 @@ properties: - Iliac-common - Iliac-external - Inguinal + - Intra-Abdominal, NOS - Mediastinal - Mesenteric - None @@ -1010,6 +1057,60 @@ properties: maximum: 100 minimum: 0 + spindle_cell_percent_range: + $ref: + - "_terms.yaml#/spindle_cell_percent/common" + enum: + - 0% + - 1-30% + - 31-60% + - 61-90% + - '>90%' + - Unknown + - Not Reported + + timepoint_category: + $ref: + - "_terms.yaml#/timepoint_category/common" + enum: + - Adjuvant Therapy + - Adolescence + - Adulthood + - After Chemotherapy + - After Study Enrollment + - Childhood + - End of Consolidation Therapy + - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 + - First Complete Response + - First Treatment + - Follow-up + - Initial Diagnosis + - Last Contact + - Post Adjuvant Therapy + - Post Hormone Therapy + - Post Initial Treatment + - Post Secondary Therapy + - Postoperative + - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy + - Prior to Diagnosis + - Prior to Procurement + - Prior to Study Enrollment + - Prior to Study Registration + - Prior to Treatment + - Progression + - Recurrence + - Recurrence/Progression + - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment + - Within 3 Months of Surgery + - Other + - Unknown + - Not Reported + transglottic_extension: $ref: - "_terms.yaml#/transglottic_extension/common" @@ -1029,6 +1130,12 @@ properties: $ref: - "_terms_enum.yaml#/not_reported/common" + tumor_basal_diameter: + $ref: + - "_terms.yaml#/tumor_basal_diameter/common" + type: number + minimum: 0 + tumor_burden: $ref: - "_terms.yaml#/tumor_burden/common" diff --git a/server/data_files/GDC/model/sample.yaml b/server/data_files/GDC/model/sample.yaml index ceae2a3..10d9689 100644 --- a/server/data_files/GDC/model/sample.yaml +++ b/server/data_files/GDC/model/sample.yaml @@ -116,6 +116,7 @@ properties: - Bowel - Brain - Brain Stem + - Brainstem - Breast - Broad Ligament - Bronchiole @@ -147,6 +148,7 @@ properties: - Clitoris - Colon - Colon - Mucosa Only + - Common Bile Duct - Common Duct - Conjunctiva - Connective Tissue @@ -373,6 +375,8 @@ properties: - Not Reported - Not Allowed To Collect deprecated_enum: + - Brain Stem + - Common Duct - Head - Face Or Neck, Nos enumDef: Bone Marrow: @@ -630,6 +634,7 @@ properties: - Hysterectomy NOS - Incisional Biopsy - Indeterminant + - Indeterminate - Laparoscopic Biopsy - Laparoscopic Partial Nephrectomy - Laparoscopic Radical Nephrectomy @@ -707,6 +712,8 @@ properties: - Unknown - Not Reported - Not Allowed To Collect + deprecated_enum: + - Indeterminant enumDef: Autopsy: $ref: diff --git a/server/data_files/GDC/model/submitted_expression_array.yaml b/server/data_files/GDC/model/submitted_expression_array.yaml index 6a2216b..57ff596 100644 --- a/server/data_files/GDC/model/submitted_expression_array.yaml +++ b/server/data_files/GDC/model/submitted_expression_array.yaml @@ -26,7 +26,7 @@ systemProperties: links: - name: aliquots - backref: submitted_genotyping_arrays + backref: submitted_expression_arrays label: derived_from target_type: aliquot multiplicity: many_to_one diff --git a/server/data_files/GDC/model/treatment.yaml b/server/data_files/GDC/model/treatment.yaml index 5ffe7f4..322615b 100644 --- a/server/data_files/GDC/model/treatment.yaml +++ b/server/data_files/GDC/model/treatment.yaml @@ -42,6 +42,7 @@ deprecated: - days_to_treatment - treatment_anatomic_site - treatment_arm + - therapeutic_level_achieved properties: @@ -114,6 +115,7 @@ properties: - Glucocorticoid - Growth factor - PARP inhibitor + - Platinum - Unknown - Not Reported @@ -158,6 +160,39 @@ properties: type: number minimum: 0 + margin_distance: + $ref: + - "_terms.yaml#/margin_distance/common" + type: number + minimum: 0 + + margin_status: + $ref: + - "_terms.yaml#/margin_status/common" + enum: + - Indeterminate + - Involved + - Uninvolved + - Unknown + - Not Reported + + margins_involved_site: + $ref: + - "_terms.yaml#/margins_involved_site/common" + enum: + - Cervix Uteri + - Gerota Fascia + - Parenchyma + - Perinephric Fat + - Renal + - Renal Capsule + - Renal Sinus + - Renal Vein + - Ureter + - Other + - Unknown + - Not Reported + number_of_cycles: $ref: - "_terms.yaml#/number_of_cycles/common" @@ -207,6 +242,15 @@ properties: - Unknown - Not Reported + pretreatment: + $ref: + - "_terms.yaml#/pretreatment/common" + enum: + - rhTSH + - Thyroxine Withdrawal + - Unknown + - Not Reported + protocol_identifier: $ref: - "_terms.yaml#/protocol_identifier/common" @@ -1838,6 +1882,7 @@ properties: - Cibisatamab - Ciclopirox Prodrug CPX-POM - Cidan Herbal Capsule + - Cidofovir - Ciforadenant - Cilengitide - Ciltacabtagene Autoleucel @@ -1938,6 +1983,7 @@ properties: - CXCR4 Inhibitor Q-122 - CXCR4 Peptide Antagonist LY2510924 - CXCR4/E-selectin Antagonist GMI-1359 + - Cyanocobalamin - Cyclin-dependent Kinase 8/19 Inhibitor BCD 115 - Cyclin-dependent Kinase Inhibitor PF-06873600 - Cyclodextrin-Based Polymer-Camptothecin CRLX101 @@ -3896,6 +3942,7 @@ properties: - Polo-like Kinase 1 Inhibitor MK1496 - Polo-like Kinase 1 Inhibitor NMS-1286937 - Polo-like Kinase 4 Inhibitor CFI-400945 Fumarate + - Poly ICLC - Poly-alendronate Dextran-Guanidine Conjugate - Poly-gamma Glutamic Acid - Polyamine Analog SL11093 @@ -6855,18 +6902,41 @@ properties: $ref: - "_terms.yaml#/timepoint_category/common" enum: + - Adjuvant Therapy + - Adolescence + - Adulthood + - After Chemotherapy + - After Study Enrollment + - Childhood - End of Consolidation Therapy - End of Treatment Course + - End of Treatment Course 1 + - End of Treatment Course 2 - First Complete Response - First Treatment + - Follow-up + - Initial Diagnosis + - Last Contact + - Post Adjuvant Therapy + - Post Hormone Therapy + - Post Initial Treatment + - Post Secondary Therapy - Postoperative - Preoperative + - Prior to Adjuvant Therapy + - Prior to Chemotherapy - Prior to Diagnosis - Prior to Procurement + - Prior to Study Enrollment - Prior to Study Registration - Prior to Treatment - Progression - Recurrence + - Recurrence/Progression + - Sample Procurement + - Within 2 Months After Completion of First-Course Treatment + - Within 3 Months of Surgery + - Other - Unknown - Not Reported @@ -7305,6 +7375,7 @@ properties: - Endocrine Gland - Epididymis - Epidural Space + - Epiglottis - Epitrochlear - Esophagogastric Junction - Esophagus @@ -7709,6 +7780,8 @@ properties: - Palliative - Prevention - Radiation Boost + - Re-Excision + - Salvage - Unknown - Not Reported enumDef: @@ -7807,6 +7880,7 @@ properties: - Ethanol Injection Ablation - External Beam Radiation - Hormone Therapy + - Hysterectomy, NOS - I-131 Radiation Therapy - Immunotherapy (Including Vaccines) - Internal Radiation diff --git a/server/service/search/controller.js b/server/service/search/controller.js index 9592b6b..7f17751 100644 --- a/server/service/search/controller.js +++ b/server/service/search/controller.js @@ -1712,8 +1712,8 @@ const generateCompareProperties = async function(req, res) { const dataset = []; // let output_file_path = path.join(__dirname, '..', '..', 'data_files', 'GDC', 'gdc_values_updated.js'); - let GDCDict = await shared.getGDCDictionaryByVersion("3.1.0"); - let GDCDictOld = await shared.getGDCDictionaryByVersion("3.0.0"); + let GDCDict = await shared.getGDCDictionaryByVersion("3.3.0"); + let GDCDictOld = await shared.getGDCDictionaryByVersion("3.1.0"); let prop_mapping = shared.readGDCProps(); for(let node in GDCDict){