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<desc>Creator: Creator: Cytoscape via FreeHEP Graphics2D Driver Producer: org.freehep.graphicsio.svg.SVGGraphics2D Source: </desc>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation of ER stress</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">necrosis </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Nuclear factor kappa B </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(NF-kB) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, blood uric acid </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">considered with MIE) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, organic anion </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">transporter 1 (OAT1) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Kidney Failure</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Necrosis</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Binding of substrate, endocytic </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">receptor </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -278.3943176269531 299.3665466308594 L -228.39431762695312 299.3665466308594 L -228.39431762695312 349.3665466308594 L -278.3943176269531 349.3665466308594 L -278.3943176269531 299.3665466308594 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Lipid peroxidation</text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 384.4434542656798, 114.9601614477037)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Disruption, Lysosome</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 127.03165715248744, 171.90136253802498)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, 5HT2c</text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 329.96256361421223, 114.24268728741806)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Cytotoxicity (renal </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 343.91694763551936, 119.36142404847763)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">tubular cell) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -490.7441101074219 24.916242599487305 L -440.7441101074219 24.916242599487305 L -440.7441101074219 74.9162425994873 L -490.7441101074219 74.9162425994873 L -490.7441101074219 24.916242599487305 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">N/A, Unknown</text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -64.99765014648438 -49.10636520385742 L 15.002349853515625 -49.10636520385742 L 15.002349853515625 30.893634796142578 L -64.99765014648438 30.893634796142578 L -64.99765014648438 -49.10636520385742 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 296.20703299744525, 151.22333560257502)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Mitochondrial dysfunction</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 985.5220336914062 -398.00775146484375 L 1035.5220947265625 -398.00775146484375 L 1035.5220947265625 -348.00775146484375 L 985.5220336914062 -348.00775146484375 L 985.5220336914062 -398.00775146484375 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 618.5528986450031, 34.69540635191896)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased proximal tubular </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 626.8473531619777, 39.81414311297853)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vectorial transport </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -171.607177734375 145.26405334472656 L -81.607177734375 145.26405334472656 L -81.607177734375 235.26405334472656 L -171.607177734375 235.26405334472656 L -171.607177734375 145.26405334472656 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 272.88370359691015, 213.66321777922846)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Oxidative Stress </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 898.321533203125 -327.0027160644531 L 948.321533203125 -327.0027160644531 L 948.321533203125 -277.0027160644531 L 898.321533203125 -277.0027160644531 L 898.321533203125 -327.0027160644531 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 588.6215823372702, 59.492507273844296)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased Na/K ATPase activity</text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 236.89539450202238, 178.3466709628644)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Mitochondrial Electron </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 242.04231440277053, 183.46540772392396)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Transport Chain Complexes </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 575.0072631835938 -274.6138000488281 L 625.0072631835938 -274.6138000488281 L 625.0072631835938 -224.6138153076172 L 575.0072631835938 -224.6138153076172 L 575.0072631835938 -274.6138000488281 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 497.0042237015536, 70.78120832222625)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Binding of inhibitor, </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 484.3520751610905, 75.89994508328581)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">NADH-ubiquinone oxidoreductase </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -318.8362731933594 -195.8920135498047 L -268.8362731933594 -195.8920135498047 L -268.8362731933594 -145.8920135498047 L -318.8362731933594 -145.8920135498047 L -318.8362731933594 -195.8920135498047 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 205.81149649936964, 97.9950821681036)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, Renal ability to dilute </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 230.03529812032846, 103.11381892916314)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">urine </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 684.2366333007812 -258.56573486328125 L 734.2366333007812 -258.56573486328125 L 734.2366333007812 -208.5657501220703 L 684.2366333007812 -208.5657501220703 L 684.2366333007812 -258.56573486328125 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 523.1668461270267, 78.36659463783208)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, NADH-ubiquinone </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 524.4502840868932, 83.48533139889165)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">oxidoreductase  (complex I) </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 223.23224900103932, 53.931767128965134)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Cytoplasmic </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 223.7151878277707, 59.0505038900247)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vacuolization (podocyte) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 566.0133472405453, 72.67100551699151)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decrease, Oxidative </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 568.9804858686234, 77.78974227805108)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">phosphorylation </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 203.32256326862702, 61.76476365225626)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Cystic dilatation (renal </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">tubule) </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 239.7149605238856, 298.5516803738327)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Unknown, MIE</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, Sodium reabsorption</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, renal ischemia</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, Renal plasma flow</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, Prostaglandin F2alpha </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">concentration, plasma </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 240.6463876043912, 75.36252761434164)">
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Cyclooxygenase 1 </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">activity </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 201.5428965606262, 70.08255318764535)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Cytoplasmic </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vacuolization (Renal tubule) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 280.987060546875 -368.0976867675781 L 330.987060546875 -368.0976867675781 L 330.987060546875 -318.0976867675781 L 280.987060546875 -318.0976867675781 L 280.987060546875 -368.0976867675781 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 395.9918225054578, 44.062798611961)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Hyperplasia (tubular </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">epithelial cells) </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -356.1044006347656 -415.9601135253906 L -306.1044006347656 -415.9601135253906 L -306.1044006347656 -365.9601135253906 L -356.1044006347656 -365.9601135253906 L -356.1044006347656 -415.9601135253906 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 198.7003061441857, 31.63235902999081)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Serum creatinine</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 306.4330139160156 -273.7278137207031 L 356.4330139160156 -273.7278137207031 L 356.4330139160156 -223.72781372070312 L 306.4330139160156 -223.72781372070312 L 306.4330139160156 -273.7278137207031 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 404.1584266404641, 73.61805458709307)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Cytotoxicity (tubular </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">epithelial cells) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -410.83428955078125 -375.2485656738281 L -360.83428955078125 -375.2485656738281 L -360.83428955078125 -325.2485656738281 L -410.83428955078125 -325.2485656738281 L -410.83428955078125 -375.2485656738281 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 184.08337581466256, 41.82324853418976)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">&#x00a0;Thyroxine (T4) in serum, </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 179.58668518066406 -283.3404541015625 L 239.58668518066406 -283.3404541015625 L 239.58668518066406 -223.3404541015625 L 179.58668518066406 -223.3404541015625 L 179.58668518066406 -283.3404541015625 z"/>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 368.7076449275706, 69.61407509524163)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Regenerative cell </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">proliferation (tubular epithelial </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 387.94800558387396, 79.85154861736078)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">cells) </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 168.58384369300987, 8.059574794060426)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Thyroid hormone synthesis, </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 183.83670225731703, 13.178311555120006)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased </text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 642.2514640302635, 8.059574794060426)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Chemical induced Fanconi </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 656.3712050671711, 13.178311555120006)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">syndrome </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 246.02638768548715, 318.94531087632606)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased Sodium-sensitive </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">hypertension </text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 399.32853420676815, 9.436919118734112)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Adenomas/carcinomas </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 415.50028737445786, 14.555655879793692)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(renal tubular) </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 361.21649949475045, 357.73809923224667)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Hyperactivation of </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 358.78115365474935, 362.8568359933063)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">ACE/Ang-II/AT1R axis </text>
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 327.19238678246035, 152.61711431764954)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 243.84685730130107, 359.3085751223929)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Chronic kidney disease</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.31318528912772314, 0, 0, 0.31318528912772314, 292.3997154304466, 303.252451257242)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased Ang II type 1 receptor </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(AT1R) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased Mortality</text>
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