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<desc>Creator: Creator: Cytoscape via FreeHEP Graphics2D Driver Producer: org.freehep.graphicsio.svg.SVGGraphics2D Source: </desc>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 382.8867593565738, 85.40363335808557)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Liver Injury</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, FAS</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 369.41631122938566, 190.79602920543542)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Cytoplasmic </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vacuolization (kupffer cell) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -590.9965209960938 -139.51992797851562 L -530.9965209960938 -139.51992797851562 L -530.9965209960938 -79.5199203491211 L -590.9965209960938 -79.5199203491211 L -590.9965209960938 -139.51992797851562 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 264.2727844751889, 143.1751250817076)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, SREBF1</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 620.8154933148564, 7.054626499727215)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Oxidative Stress </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 217.1096173200389, 142.04606186345012)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, Mitochondrial fatty </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 222.08569071576406, 144.53546861725502)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">acid beta-oxidation </text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -369.61083984375 797.9292602539062 L -279.61083984375 797.9292602539062 L -279.61083984375 887.9292602539062 L -369.61083984375 887.9292602539062 L -369.61083984375 797.9292602539062 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 297.63150385166244, 286.9999630150336)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, hepatocellular </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 296.38680163680914, 289.4893697688385)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">adenomas and carcinomas </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -328.3797302246094 -159.0030975341797 L -278.3797302246094 -159.0030975341797 L -278.3797302246094 -109.00308990478516 L -328.3797302246094 -109.00308990478516 L -328.3797302246094 -159.0030975341797 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 303.4880920980561, 139.4460419756028)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, FA Influx</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 42.34017562866211 170.09555053710938 L 92.34017944335938 170.09555053710938 L 92.34017944335938 220.09555053710938 L 42.34017562866211 220.09555053710938 L 42.34017562866211 170.09555053710938 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.0077877690363, 188.32704662740824)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Cytoplasmic </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 355.84533539268705, 190.81645338121314)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vacuolization (Bile duct cell) </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -428.0633239746094 -220.6477813720703 L -378.0633239746094 -220.6477813720703 L -378.0633239746094 -170.6477813720703 L -428.0633239746094 -170.6477813720703 L -428.0633239746094 -220.6477813720703 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 285.0571455198371, 128.81210700601767)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Suppression, Constitutive </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 284.12681710845726, 131.30151375982257)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">androstane receptor, NR1l3 </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1747.064697265625 -933.8553466796875 L 1797.064697265625 -933.8553466796875 L 1797.064697265625 -883.8553466796875 L 1747.064697265625 -883.8553466796875 L 1747.064697265625 -933.8553466796875 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 618.7763410951828, 21.426664400882906)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation of Cyp2E1</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -491.885009765625 -186.47479248046875 L -411.885009765625 -186.47479248046875 L -411.885009765625 -106.47480010986328 L -491.885009765625 -106.47480010986328 L -491.885009765625 -186.47479248046875 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 279.909367742403, 137.54645185827917)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, CD36</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -609.3523559570312 1198.936279296875 L -559.3523559570312 1198.936279296875 L -559.3523559570312 1248.936279296875 L -609.3523559570312 1248.936279296875 L -609.3523559570312 1198.936279296875 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 258.9653260385523, 346.2766477001642)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Cholestasis, Pathology</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 434.053955078125 363.1843566894531 L 484.053955078125 363.1843566894531 L 484.053955078125 413.1843566894531 L 434.053955078125 413.1843566894531 L 434.053955078125 363.1843566894531 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 421.4382464051907, 218.9815126317997)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">IFN&#x03b3; signaling</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 77.0933837890625 199.41915893554688 L 127.0933837890625 199.41915893554688 L 127.0933837890625 249.41915893554688 L 77.0933837890625 249.41915893554688 L 77.0933837890625 199.41915893554688 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 362.8933168493935, 192.79338716554938)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Ballooning </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 361.5499148283354, 195.28279391935428)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">degeneration (hepatocyte) </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -398.81787109375 87.83203887939453 L -338.81787109375 87.83203887939453 L -338.81787109375 147.83203125 L -398.81787109375 147.83203125 L -398.81787109375 87.83203887939453 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 293.34743420810844, 177.8035806977715)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, ChREBP</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 412.88490581394785, 178.03801946463835)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Endocytotic lysosomal uptake</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 238.23747428179078, 152.7434342579261)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, CYP1A1</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 333.41552734375 303.7804260253906 L 383.41552734375 303.7804260253906 L 383.41552734375 353.7804260253906 L 333.41552734375 353.7804260253906 L 333.41552734375 303.7804260253906 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 402.4689027031207, 209.93357487309038)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Immune cell activation</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 88.53738403320312 158.19168090820312 L 138.53738403320312 158.19168090820312 L 138.53738403320312 208.19168090820312 L 88.53738403320312 208.19168090820312 L 88.53738403320312 158.19168090820312 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 364.0441812716659, 186.51394317977235)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Occurrence, Cytoplasmic </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 363.4711818104154, 189.00334993357725)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">vacuolization (hepatocyte) </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -554.0050659179688 -237.69715881347656 L -494.0050354003906 -237.69715881347656 L -494.0050354003906 -177.69715881347656 L -554.0050659179688 -177.69715881347656 L -554.0050659179688 -237.69715881347656 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 263.1616842126195, 126.97684095708271)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">peroxisome proliferator activated </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 263.0629855684638, 129.46624771088761)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">receptor promoter demethylation </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 296.82684326171875 53.854373931884766 L 346.82684326171875 53.854373931884766 L 346.82684326171875 103.85437774658203 L 296.82684326171875 103.85437774658203 L 296.82684326171875 53.854373931884766 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 397.3310069916182, 171.86681222240162)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Disruption, Lysosome</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 207.32026547950048, 160.57049500489583)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">N/A, Steatohepatisis</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 304.04412841796875 143.77783203125 L 354.04412841796875 143.77783203125 L 354.04412841796875 193.77783203125 L 304.04412841796875 193.77783203125 L 304.04412841796875 143.77783203125 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 399.2034283999248, 185.56324288482637)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Apoptotic cell death</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Disturbance, Lysosomal function</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, LXR</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Liver Cancer</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation of ER stress</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Damage, Lipid bilayer</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation of specific nuclear </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 265.54363744400797, 339.4820626800809)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">receptors, Transcriptional change </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 146.1461181640625 -162.05499267578125 L 226.1461181640625 -162.05499267578125 L 226.1461181640625 -82.05499267578125 L 146.1461181640625 -82.05499267578125 L 146.1461181640625 -162.05499267578125 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Cell injury/death</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">N/A, Liver fibrosis</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 247.99578857421875 188.74758911132812 L 297.99578857421875 188.74758911132812 L 297.99578857421875 238.74758911132812 L 247.99578857421875 238.74758911132812 L 247.99578857421875 188.74758911132812 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">benzoquinone imine and </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">acylglucuronide metabolites </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 179.97894287109375 162.35787963867188 L 229.97894287109375 162.35787963867188 L 229.97894287109375 212.35787963867188 L 179.97894287109375 212.35787963867188 L 179.97894287109375 162.35787963867188 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 377.09268703009883, 188.3932090575448)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Phospholipase A</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
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  <path d="M -633.579833984375 979.4598999023438 L -583.579833984375 979.4598999023438 L -583.579833984375 1029.4598388671875 L -633.579833984375 1029.4598388671875 L -633.579833984375 979.4598999023438 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 252.51070546822027, 311.6030255579209)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Production, Reactive oxygen </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 261.54531219913474, 314.09243231172576)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">species </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -17.719881057739258 -97.6856460571289 L 42.28011894226074 -97.6856460571289 L 42.28011894226074 -37.685646057128906 L -17.719881057739258 -37.685646057128906 L -17.719881057739258 -97.6856460571289 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 349.48143440131065, 149.54699264625572)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Stellate cells</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1207.5245361328125 -904.7327270507812 L 1257.5245361328125 -904.7327270507812 L 1257.5245361328125 -854.7327270507812 L 1207.5245361328125 -854.7327270507812 L 1207.5245361328125 -904.7327270507812 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 531.9992032789382, 24.617688539437943)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Tumorigenesis, Hepatocellular </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 540.6225677896274, 27.107095293242814)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">carcinoma </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 431.3968505859375 244.21121215820312 L 481.3968505859375 244.21121215820312 L 481.3968505859375 294.2112121582031 L 431.3968505859375 294.2112121582031 L 431.3968505859375 244.21121215820312 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 416.4184485862754, 200.86046248169737)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase in inflammation</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -725.7090454101562 1069.3720703125 L -675.7090454101562 1069.3720703125 L -675.7090454101562 1119.3720703125 L -725.7090454101562 1119.3720703125 L -725.7090454101562 1069.3720703125 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 237.3569815100561, 326.5424502229553)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Oxidative metabolism</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -653.8240356445312 1100.1365966796875 L -603.8240356445312 1100.1365966796875 L -603.8240356445312 1150.1365966796875 L -653.8240356445312 1150.1365966796875 L -653.8240356445312 1100.1365966796875 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 248.21089703104232, 329.9835659303643)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Bile accumulation, Pathological </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 257.5671891786524, 332.4729540913829)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">condition </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 108.36557006835938 19.4121150970459 L 208.36557006835938 19.4121150970459 L 208.36557006835938 119.4121150970459 L 108.36557006835938 119.4121150970459 L 108.36557006835938 19.4121150970459 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 370.47909000234625, 170.42864160739717)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Mitochondrial dysfunction</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 81.9302978515625 942.7108764648438 L 131.9302978515625 942.7108764648438 L 131.9302978515625 992.7108764648438 L 81.9302978515625 992.7108764648438 L 81.9302978515625 942.7108764648438 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 365.58117138393715, 307.2504170937282)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, SREBP1c</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1948.1356201171875 -845.3634643554688 L 1998.1356201171875 -845.3634643554688 L 1998.1356201171875 -795.3634643554688 L 1948.1356201171875 -795.3634643554688 L 1948.1356201171875 -845.3634643554688 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 643.8665067505987, 33.66034594683102)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Proliferation, Cell proliferation in </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 646.5176730695271, 36.14975270063591)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">the absence of cytotoxicity </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -468.1792297363281 936.2642211914062 L -418.1792297363281 936.2642211914062 L -418.1792297363281 986.2642211914062 L -468.1792297363281 986.2642211914062 L -468.1792297363281 936.2642211914062 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 280.9648534949278, 306.2685134551326)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Cytotoxicity</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -663.6089477539062 1304.5552978515625 L -613.6089477539062 1304.5552978515625 L -613.6089477539062 1354.5552978515625 L -663.6089477539062 1354.5552978515625 L -663.6089477539062 1304.5552978515625 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 250.3550334186986, 362.3637028046996)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Inflammation</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -47.14609146118164 -205.65769958496094 L 2.8539085388183594 -205.65769958496094 L 2.8539085388183594 -155.65769958496094 L -47.14609146118164 -155.65769958496094 L -47.14609146118164 -205.65769958496094 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 340.03771882714545, 132.3399813026145)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Leukocyte recruitment/activation</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -252.6231689453125 753.771240234375 L -202.6231689453125 753.771240234375 L -202.6231689453125 803.771240234375 L -252.6231689453125 803.771240234375 L -252.6231689453125 753.771240234375 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 310.1913981577763, 277.2279198965144)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Phenotypic enzyme </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Clonal Expansion of </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(ABCB11) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Tissue resident cell activation</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Altered gene expression specific to </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, LDL uptake</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Metabolism of AFB1, Production of </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased Ang II type 1 receptor </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, LDLR (low density </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">lipoprotein receptor) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Induced Mutations in </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Critical Genes </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase plasma Ang II</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Suppression, VLDL secretion</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Formation, Pro-mutagenic DNA </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Induced dysregulation of ACE2 </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Down Regulation, GSS and GSTs </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 483.6191103696549, 80.08686806984429)">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation of hepatic stellate cells</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Accumulation, Triglyceride</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, LXR alpha</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, extracellular matrix </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, Unsaturated fatty </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Accumulation of misfolded proteins</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, PCK1 expression </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(control point for </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">glycolysis/gluconeogenesis </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">pathway) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, DHB4/HSD17B4</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">mitochondrial complex V </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, SREBF2</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition of N-linked glycosylation</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, AhR</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, SHP</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 431.47941080936727, 103.71491560146939)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Binding of inhibitor to </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 429.92673070953623, 106.20432235527429)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">mitochondrial complex IV </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 568.6729874058831, 12.400071160874399)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">N/A, Hepatotoxicity, Hepatopathy, </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">including a constellation of </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 575.4704159602248, 17.37888466848417)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">observable effects </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 377.85128433263947, 42.76342990977948)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Unfolded Protein Response</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -727.8634033203125 178.36502075195312 L -677.8634033203125 178.36502075195312 L -677.8634033203125 228.36502075195312 L -727.8634033203125 228.36502075195312 L -727.8634033203125 178.36502075195312 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 235.99068131058988, 190.83129042470026)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, fatty acid beta oxidation</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -141.24266052246094 762.0046997070312 L -91.24266052246094 762.0046997070312 L -91.24266052246094 812.0046997070312 L -141.24266052246094 812.0046997070312 L -141.24266052246094 762.0046997070312 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 332.19787001984406, 279.7266788218406)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, NR1H4</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 390.45086669921875 -428.6988525390625 L 440.45086669921875 -428.6988525390625 L 440.45086669921875 -378.6988525390625 L 390.45086669921875 -378.6988525390625 L 390.45086669921875 -428.6988525390625 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 411.2191304431001, 97.12341029001806)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Binding of inhibitor to </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 409.59516908664745, 99.61281704382294)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">mitochondrial complex III </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1463.16357421875 -866.6215209960938 L 1513.16357421875 -866.6215209960938 L 1513.16357421875 -816.6215209960938 L 1463.16357421875 -816.6215209960938 L 1463.16357421875 -866.6215209960938 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 569.4510664623446, 30.422486579523984)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Alterations, Cellular proliferation / </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 579.0650790314476, 32.91189333332887)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">hyperplasia </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 191.7119140625 -660.201416015625 L 241.7119140625 -660.201416015625 L 241.7119140625 -610.201416015625 L 191.7119140625 -610.201416015625 L 191.7119140625 -660.201416015625 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 386.37265346574765, 63.107470778439584)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Apoptosis</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -873.4822998046875 281.87127685546875 L -823.4822998046875 281.87127685546875 L -823.4822998046875 331.87127685546875 L -873.4822998046875 331.87127685546875 L -873.4822998046875 281.87127685546875 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 216.91743763238986, 206.5965462317238)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, HSD17B4 activity</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -94.9727783203125 876.0198364257812 L -44.972782135009766 876.0198364257812 L -44.972782135009766 926.0198364257812 L -94.9727783203125 926.0198364257812 L -94.9727783203125 876.0198364257812 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 339.9709527124779, 297.09256436257755)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, NRF2</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 202.92132568359375 -33.316349029541016 L 252.92132568359375 -33.316349029541016 L 252.92132568359375 16.683650970458984 L 202.92132568359375 16.683650970458984 L 202.92132568359375 -33.316349029541016 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 377.47350215550375, 157.3449521964798)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased reactive oxygen species </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 383.0810667562079, 159.8343586597724)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(in the mitochondria) </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1362.28271484375 -1028.2144775390625 L 1412.28271484375 -1028.2144775390625 L 1412.28271484375 -978.2144165039062 L 1362.28271484375 -978.2144165039062 L 1362.28271484375 -1028.2144775390625 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 556.7130974211072, 5.809923122824751)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Changes/Inhibition, Cellular </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 556.7679263859297, 8.29932987662965)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Homeostasis and Apoptosis </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 19.731290817260742 31.75960350036621 L 69.73129081726074 31.75960350036621 L 69.73129081726074 81.75960350036621 L 19.731290817260742 81.75960350036621 L 19.731290817260742 31.75960350036621 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 356.92085952067333, 168.50151092533)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, PARP1</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -1007.68359375 369.04632568359375 L -957.68359375 369.04632568359375 L -957.68359375 419.04632568359375 L -1007.68359375 419.04632568359375 L -1007.68359375 369.04632568359375 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 199.08973400647687, 219.8743614720963)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, PPARalpha</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -510.5433654785156 169.13577270507812 L -450.5433654785156 169.13577270507812 L -450.5433654785156 229.13577270507812 L -510.5433654785156 229.13577270507812 L -510.5433654785156 169.13577270507812 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 270.5024788129575, 190.18712474969354)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, De Novo FA synthesis</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 352.8106689453125 -163.57127380371094 L 402.8106689453125 -163.57127380371094 L 402.8106689453125 -113.57128143310547 L 352.8106689453125 -113.57128143310547 L 352.8106689453125 -163.57127380371094 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 403.6537454424015, 137.50555005246304)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decrease in mitochondrial </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 403.72502902312135, 139.9949568062679)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">oxidative phosphorylation </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1368.1612548828125 -917.7646484375 L 1418.1612548828125 -917.7646484375 L 1418.1612548828125 -867.7646484375 L 1368.1612548828125 -867.7646484375 L 1368.1612548828125 -917.7646484375 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 554.3989241922654, 21.38806577647275)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Long term AHR receptor </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 556.3911819186808, 23.87747253027765)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">driven direct and indirect gene </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 561.0611041706845, 26.366879284082522)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">expression changes </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -1043.632568359375 -107.09984588623047 L -993.632568359375 -107.09984588623047 L -993.632568359375 -57.0998420715332 L -1043.632568359375 -57.0998420715332 L -1043.632568359375 -107.09984588623047 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 189.2559791060476, 146.10683214324413)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, 3-hydroxyacyl-CoA </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 189.3446260250965, 148.596238897049)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">dehydrogenase type-2 activity </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -1133.7161865234375 444.4053649902344 L -1083.7161865234375 444.4053649902344 L -1083.7161865234375 494.4053649902344 L -1133.7161865234375 494.4053649902344 L -1133.7161865234375 444.4053649902344 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 182.71093368147433, 231.35245542279014)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activated, LXR</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Mitochondrial fatty acid </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, PPAR-beta activation</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, PPAR&#x03b1;</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">NADH-ubiquinone oxidoreductase </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(complex I) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decrease, Acyl-CoA </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, PPAR-alpha activation</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Reduced, FXR activity</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, Ketogenesis</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, NADH-ubiquinone </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 423.9531101696216, 139.77383047440958)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">oxidoreductase  (complex I) </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 318.11987587236484, 91.43422684349578)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Glucocorticoid Receptor</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, HSD17B10 expression</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">NFE2/Nrf2 repression</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Down Regulation, HMGCS2</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Mitochondrial Complex V inhibition</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 389.24734342392117, 146.76622066205422)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Tissue resident cells </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(Kuppfer cells) </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Decreased, PPAR-gamma </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 157.46989802347562, 149.68386111868693)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">activation </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 264.50915805388274, 169.55143801576827)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Liver Steatosis</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Down Regulation, CPT1A</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 432.8170386082224, 209.17360867665664)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Immune mediated hepatitis</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 413.3513093450513, 120.20549459580711)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Mitochondrial Complex IV inhibition</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Necrotic Tissue</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Regenerative cell </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">proliferation (hepatocytes) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Oncotic Necrosis</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, FoxA2</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Promotion, Hepatocelluar </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">carcinoma </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Mitochondrial complex </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">III antagonism </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Nuclear factor kappa B </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 432.8028685809447, 156.53012536938436)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(NF-kB) </text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.9632454931832, 282.86950116184875)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Cytotoxicity (hepatocytes)</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, Fatty Acid Beta Oxidation</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 269.217897395536, 148.04521378513604)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, FA Influx</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Hepatotoxicity</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 223.9732768654168, 104.90116790636345)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">systemic inflammation leading to </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">hepatic steatosis </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 335.38427734375 -99.16700744628906 L 385.38427734375 -99.16700744628906 L 385.38427734375 -49.16701126098633 L 335.38427734375 -49.16701126098633 L 335.38427734375 -99.16700744628906 z"/>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Caspase 8 pathway</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -201.3596649169922 800.8592529296875 L -131.3596649169922 800.8592529296875 L -131.3596649169922 870.8592529296875 L -201.3596649169922 870.8592529296875 L -201.3596649169922 800.8592529296875 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 320.27834729827754, 285.92311531307087)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Preneoplastic foci </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 326.26974137986946, 288.41252206687574)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">(hepatocytes) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -624.453857421875 190.74215698242188 L -574.453857421875 190.74215698242188 L -574.453857421875 240.74215698242188 L -624.453857421875 240.74215698242188 L -624.453857421875 190.74215698242188 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 254.29549675048017, 192.71647810491712)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, cytosolic fatty acid</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -467.6413269042969 -133.65943908691406 L -397.6413269042969 -133.65943908691406 L -397.6413269042969 -63.65943908691406 L -467.6413269042969 -63.65943908691406 L -467.6413269042969 -133.65943908691406 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 282.56716355170533, 144.8293090123311)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, SCD-1</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 1371.8455810546875 -807.1575927734375 L 1421.8455810546875 -807.1575927734375 L 1421.8455810546875 -757.1575927734375 L 1371.8455810546875 -757.1575927734375 L 1371.8455810546875 -807.1575927734375 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 555.2388277494041, 39.4795626927119)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Formation, Hepatocellular and Bile </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 564.8884757175967, 41.96896944651679)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">duct tumors </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M -704.5849609375 -277.3490295410156 L -654.5849609375 -277.3490295410156 L -654.5849609375 -227.34902954101562 L -704.5849609375 -227.34902954101562 L -704.5849609375 -277.3490295410156 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 247.19914499810076, 121.42052388573528)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, AKT2</text>
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<g fill="#b6d7a8" fill-rule="nonzero" fill-opacity="1" stroke="none">
  <path d="M 614.3387451171875 -14.703897476196289 L 664.3387451171875 -14.703897476196289 L 664.3387451171875 35.29610252380371 L 614.3387451171875 35.29610252380371 L 614.3387451171875 -14.703897476196289 z"/>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 445.03849191101455, 161.42455682356461)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inhibition, IKK complex</text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 357.6198285954213, 159.1471657910628)">
<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 281.8211988854232, 175.7741408848542)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Up Regulation, Acetyl-CoA </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 283.7385183865566, 178.26354763865908)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">carboxylase-1 (ACC-1) </text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 236.37812708841784, 178.02519276617258)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Reactive oxygen species</text>
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<g fill="#ffe599" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, Triglyceride formation</text>
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<g fill="#ea9999" fill-rule="nonzero" fill-opacity="1" stroke="none">
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 408.7223760525495, 156.17249196237896)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, proinflammatory </text>
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<g transform="matrix(0.1523121055722164, 0, 0, 0.1523121055722164, 410.9513280832227, 158.66189857092772)">
<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">mediators (TNFalpha) </text>
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