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<desc>Creator: Creator: Cytoscape via FreeHEP Graphics2D Driver Producer: org.freehep.graphicsio.svg.SVGGraphics2D Source: </desc>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased neurokinin A (NKA) by </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">persistent, cytotoxicity (pleura or </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">peritoneum) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Induced dysregulation of ACE2 </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, secretion of local </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">growth factors </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Chromosomal </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">aberrations </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Binding of agonist, Angiotensin II </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">receptor type 1 receptor (AT1R) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Oxidative Stress </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Deposition of Energy</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased activation, Nuclear </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">factor kappa B (NF-kB) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Activation, Transforming Growth </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Factor beta pathway </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, DNA strand breaks</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased inflammatory immune </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Inadequate DNA repair</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, the risk of acute </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">respiratory failure </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, activation of T (T) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, Cytotoxicity (club cells)</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, recruitment of </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">bronchiolar cells) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Non-coding RNA expression profile </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increased, secretion of </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">proinflammatory mediators </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">proliferation (terminal bronchiolar </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">epithelial cells) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">resident cell membrane </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">bronchiolar cells) </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Mucociliary Clearance, Decreased</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">FOXJ1 Protein, Decreased</text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Cystic Fibrosis Transmembrane </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Trigeminal and/or vagal nerve </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">excitation causes Airway </text>
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<text font-weight="normal" font-size="12" font-family="Helvetica" font-style="normal" fill="#000000" fill-opacity="1" stroke="none" x="0" y="0">Increase, goblet cell number</text>
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