Skip to content

Commit

Permalink
Fix some typos in tutorial
Browse files Browse the repository at this point in the history
  • Loading branch information
const-ae committed Apr 17, 2024
1 parent ed8179a commit 3e2f987
Showing 1 changed file with 2 additions and 2 deletions.
4 changes: 2 additions & 2 deletions docs/notebooks/Tutorial.myst
Original file line number Diff line number Diff line change
Expand Up @@ -9,11 +9,11 @@ kernelspec:
# pyLemur Walkthrough


The goal of `pyLemur` is to simplify analysis of multi-condition single-cell data. If you have collected a single-cell RNA-seq dataset with more than one condition, lemur predicts for each cell and gene how much the expression would change if the cell had been in the other condition.
The goal of `pyLemur` is to simplify analysis of multi-condition single-cell data. If you have collected a single-cell RNA-seq dataset with more than one condition, LEMUR predicts for each cell and gene how much the expression would change if the cell had been in the other condition.

`pyLemur` is a Python implementation of the LEMUR model; there is also an `R` package called [lemur](https://bioconductor.org/packages/lemur/) which provides additional functionality: identifying neighborhoods of cells that show consistent differential expression values and a pseudo-bulk test to validate the findings.

`pyLemur` implements a novel framework to disentangle the effects of known covariates, latent cell states, and their interactions. At the core, is a combination of matrix factorization and regression analysis implemented as geodesic regression on Grassmann manifolds. We call this latent embedding multivariate regression. For more details see our [preprint](https://www.biorxiv.org/content/10.1101/2023.03.06.531268) {cite:p}`Ahlmann-Eltze2024`.
`pyLemur` implements a novel framework to disentangle the effects of known covariates, latent cell states, and their interactions. At the core, is a combination of matrix factorization and regression analysis implemented as geodesic regression on Grassmann manifolds. We call this latent embedding multivariate regression (LEMUR). For more details see our [preprint](https://www.biorxiv.org/content/10.1101/2023.03.06.531268) {cite:p}`Ahlmann-Eltze2024`.

<img src="../_static/images/equation_schematic.png" alt="Schematic of the matrix decomposition atthe core of LEMUR" />

Expand Down

0 comments on commit 3e2f987

Please sign in to comment.