diff --git a/src/paho/mqtt/client.py b/src/paho/mqtt/client.py
index 4ccc8696..2eb081b0 100644
--- a/src/paho/mqtt/client.py
+++ b/src/paho/mqtt/client.py
@@ -1704,7 +1704,11 @@ def _loop(self, timeout: float = 1.0) -> MQTTErrorCode:
             if rc or self._sock is None:
                 return rc
 
-        return self.loop_misc()
+        rc = self.loop_misc()
+        if rc == MQTT_ERR_SUCCESS:
+            # Make the main loop to update inflight packets
+            return self._update_inflight()
+        return rc
 
     def publish(
         self,