diff --git a/CHANGELOG.asciidoc b/CHANGELOG.asciidoc
index c7d2cb9c32..3845bbb410 100644
--- a/CHANGELOG.asciidoc
+++ b/CHANGELOG.asciidoc
@@ -33,6 +33,25 @@ Notes:
 
 See the <<upgrade-to-v4>> guide.
 
+==== Unreleased
+
+[float]
+===== Breaking changes
+
+[float]
+===== Features
+
+[float]
+===== Bug fixes
+
+* Fix path resolution for requests that contain invalid characters in its
+  host header. ({pull}3923[#3923])
+* Fix span names for `getMore` command of mongodb. ({pull}3919[#3919])
+
+[float]
+===== Chores
+
+
 [[release-notes-4.5.0]]
 ==== 4.5.0 - 2024/03/13
 
@@ -46,7 +65,6 @@ See the <<upgrade-to-v4>> guide.
 [float]
 ===== Bug fixes
 
-* Fix span names for `getMore` command of mongodb. ({pull}3919[#3919])
 * Fix instrumentation of mongodb to not break mongodb@6.4.0. Mongodb v6.4.0
   included changes that resulted in the APM agent's instrumentation breaking it.
   ({pull}3897[#3897])
diff --git a/lib/instrumentation/express-utils.js b/lib/instrumentation/express-utils.js
index 0a2edb6520..fb82e47c35 100644
--- a/lib/instrumentation/express-utils.js
+++ b/lib/instrumentation/express-utils.js
@@ -63,10 +63,23 @@ function getPathFromRequest(req, useBase, usePathAsTransactionName) {
     //
     // Assuming 'http://' for the `base` URL is fine, because we don't use the
     // protocol.
-    const base = 'http://' + (req.headers && req.headers.host);
+    let base;
+    try {
+      // Host header may contain invalid characters therefore the URL
+      // parsing will fail and break the app. This try block is to avoid it
+      // Ref: https://github.com/elastic/apm-agent-nodejs/issues/3874
+      const url = new url.URL('http://' + (req.headers && req.headers.host));
+      base = 'http://' + url.hostname;
+    } catch (err) {
+      base = 'http://undefined';
+    }
+
+    // We may receive invalid chars in the path also but the URL
+    // constructor escapes them without throwing.
     const parsed = req.url.startsWith('/')
       ? new url.URL(base + req.url)
       : new url.URL(req.url, base);
+
     return parsed && parsed.pathname;
   }
 }
diff --git a/test/instrumentation/express-utils.test.js b/test/instrumentation/express-utils.test.js
index 3917d13284..50e563e6e8 100644
--- a/test/instrumentation/express-utils.test.js
+++ b/test/instrumentation/express-utils.test.js
@@ -26,6 +26,16 @@ test('#getPathFromRequest', function (t) {
     t.equals(path, '/foo/bar');
     t.end();
   });
+
+  t.test('should return path for an invalid host header', function (t) {
+    const req = createRequest(
+      'https://test.com/foo/bar?query=value#hash',
+      'invalid[hostname',
+    );
+    const path = getPathFromRequest(req, false, true);
+    t.equals(path, '/foo/bar');
+    t.end();
+  });
 });
 
 function createRequest(url, host = 'example.com') {