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# Newt: A Sample Application for ChiSE
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Newt is a sample application for the web based library named [ChiSE](https://github.com/iVis-at-Bilkent/chise.js) developed to visualize and edit the pathway models represented by process description (PD) and activity flow (AF) languages of [SBGN](http://sbgn.org) or in [simple interaction format (SIF)](https://www.pathwaycommons.org/pc/sif_interaction_rules.do).
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## Software
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Newt is a sample application for the web based library named [ChiSE](https://github.com/iVis-at-Bilkent/chise.js) developed to visualize and edit the pathway models represented by process description (PD) and activity flow (AF) languages of [SBGN](http://sbgn.org), [SBML](https://sbml.org/) or [simple interaction format (SIF)](https://www.pathwaycommons.org/pc/sif_interaction_rules.do).
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ChiSE and this sample application are distributed under [GNU Lesser General Public License](http://www.gnu.org/licenses/lgpl.html).
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**A deployment of this sample application along with detailed documentation on its usage** can be found [here](http://newteditor.org/). ChiSE and Newt work on every platform that have JavaScript support including mobile devices.
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### How to Cite Usage
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Please cite the following when you use Newt:
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H. Balci, M.C. Siper, N. Saleh, I. Safarli, L. Roy, M. Kilicarslan, R. Ozaydin, A. Mazein, C. Auffray, O. Babur, E. Demir and U. Dogrusoz, [Newt: a comprehensive web-based tool for viewing,constructing, and analyzing biological maps](https://doi.org/10.1093/bioinformatics/btaa850), **Bioinformatics**, 37(10), pp.1475-1477, 2021.
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## Software
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**A deployment of this sample application along with detailed documentation on its usage** can be found [here](http://newteditor.org/). ChiSE and Newt work on every platform that have JavaScript support including mobile devices.
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#### Running a Local Instance
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In order to deploy and run a local instance of the tool, please follow the steps below (we recommend the use of LTS version 12.16.1 of node.js):
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In order to deploy and run a local instance of the tool, please follow the steps below (we recommend the use of version 14.19.3 of node.js):
[Request](https://github.com/request/request) licensed with [Apache-2.0](https://www.apache.org/licenses/LICENSE-2.0),
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[Intro.js](https://github.com/usablica/intro.js) licensed with [GNU AGPL](https://www.gnu.org/licenses/agpl-3.0.en.html), and
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[chroma-js](https://github.com/gka/chroma.js) licensed with [this](https://github.com/gka/chroma.js/blob/master/LICENSE).
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We refer the user to [GeneCards](https://www.genecards.org/) for detailed properties of genes. Similarly, we pull properties of simple chemicals from [ChEBI](https://www.ebi.ac.uk/chebi/). CellDesigner conversion is performed through [this library](https://github.com/royludo/cd2sbgnml) and [its associated service](https://github.com/iVis-at-Bilkent/cd2sbgnml-webservice). Finally, SBML conversion is due to [this Minerva service](https://minerva-dev.lcsb.uni.lu/minerva/api/convert/).
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We refer the user to [GeneCards](https://www.genecards.org/) for detailed properties of genes. Similarly, we pull properties of simple chemicals from [ChEBI](https://www.ebi.ac.uk/chebi/). CellDesigner conversion is performed through [this library](https://github.com/royludo/cd2sbgnml) and [its associated service](https://github.com/iVis-at-Bilkent/cd2sbgnml-webservice). Finally, SBML and GPML conversions are due to [this Minerva service](https://minerva-dev.lcsb.uni.lu/minerva/api/convert/).
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## Team
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*[Hasan Balci](https://github.com/hasanbalci), [Nasim Saleh](https://github.com/nasimsaleh), [Merve Kilicarslan](https://github.com/mervekilicarslan5), [Rumeysa Ozaydin](https://github.com/rumeysaozaydin), and [Ugur Dogrusoz](https://github.com/ugurdogrusoz) of [i-Vis at Bilkent University](http://www.cs.bilkent.edu.tr/~ivis), and [Metin Can Siper](https://github.com/metincansiper), [Ozgun Babur](https://github.com/ozgunbabur), and [Emek Demir](https://github.com/emekdemir) of the Demir Lab at [OHSU](http://www.ohsu.edu/)
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*[Hasan Balci](https://github.com/hasanbalci), [Selbi Ereshova](https://github.com/SelbiEreshova), [Umut Utku Ersahince](https://github.com/umut-er), [Noor Muhammad](https://github.com/NoorMuhammad1) and [Ugur Dogrusoz](https://github.com/ugurdogrusoz) of [i-Vis at Bilkent University](http://www.cs.bilkent.edu.tr/~ivis), [Ozgun Babur](https://github.com/ozgunbabur) of University of Massachusetts at Boston, and [Emek Demir](https://github.com/emekdemir) of the Demir Lab at [OHSU](http://www.ohsu.edu/)
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