Repositories list

• CNP25-CHIKV-nsP3-Macrodomain

  Public
  This project aims to develop a chemical probe of CHIKV-nsP3-macrodomain starting from a fragment screen

  drug-discoveryhigh-throughput-screeningmedicinal-chemistry+ 3antiviralhigh-throughput-crystallographic-fragment-screenchikv-nsp3-macrodomain

  0•1•10•0•Updated Feb 27, 2025Feb 27, 2025

• CNP27-SARS-CoV-2-NSP14

  Public
  This project aims to develop a chemical probe of SARS-CoV2-NSP14 starting from a fragment screen

  drug-discoveryantivirushigh-throughput-screening+ 1medicinal-chemistry

  0•0•4•0•Updated Feb 12, 2025Feb 12, 2025

• CNP42-CHIKV-nsP3-MD-ASMS

  Public
  This CNP will showcase the progress of ASMS screens for CHIKV nsP3 Macrodomain

  0•0•0•0•Updated Jan 9, 2025Jan 9, 2025

• CNP41-DENVRdRp-ASMS-HTS

  Public
  An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on the results from an ASMS HTS screen. Use the link below to learn about other READDI-AViDD projects.

  drug-discoveryhigh-throughput-screeningmedicinal-chemistry

  0•0•0•0•Updated Dec 20, 2024Dec 20, 2024

• CNP18-DENVRdrp-VirtualScreen

  Public
  An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on the results from a virtual screening campaign of the Enamine REAL space to identify hits. Use the link below to learn about other READDI-AViDD projects.

  drug-discoveryvirtual-screeningmedicinal-chemistry

  0•1•5•0•Updated Dec 20, 2024Dec 20, 2024

• CNP21-CHIKVhelicase-Asinex

  Public
  An SGC Open Chemistry Networks Project (number 21) dedicated to finding hits vs CHIKV nsp2 helicase based on a HTS of a Asinex library.

  drug-discoveryhigh-throughput-screeningmedicinal-chemistry

  0•0•4•0•Updated Dec 20, 2024Dec 20, 2024

• CNP26_DENVRdrp_ReferenceCmpds

  Public
  An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on identifying a DENV reference compound. If you would like to learn about other repositories in the READDI-AViDD pipeline, please use the link below.

  drug-discoverymedicinal-chemistry

  0•0•0•0•Updated Dec 19, 2024Dec 19, 2024

• CNP11-DENVRdrp-LifeChem

  Public
  An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the LifeChemicals library. Use the link below to learn about our other READDI-AViDD projects.

  drug-discoveryhigh-throughput-screeningmedicinal-chemistry

  0•0•1•0•Updated Dec 19, 2024Dec 19, 2024

• CNP17-DENVRdrp-EnamineCovalent

  Public
  An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the Enamine covalent library. Use the link below to learn about other READDI-AViDD projects.

  drug-discoveryhigh-throughput-screeningmedicinal-chemistry+ 1covalent-drug

  0•0•2•0•Updated Dec 18, 2024Dec 18, 2024

• CNP13_RBBP4_Pf_ortho

  Public
  A descriptive page for biological characterisation and development of hits vs Pfal RBBP4 orthologue

  0•0•3•0•Updated Dec 11, 2024Dec 11, 2024

• CNP12-Nsp15-TAMU

  Public
  An SGC Open Chemistry Networks Project (number 12) devoted to the target SARS-CoV-2 Nsp15.

  0•0•7•0•Updated Sep 23, 2024Sep 23, 2024

• CNP19-CHIKVhelicase-Covalent

  Public
  An SGC Open Chemistry Networks Project (number 19) dedicated to finding hits vs CHIKV nsp2 helicase based on a HTS of a Enamine Covalent library.

  drug-discoveryhigh-throughput-screeningmedicinal-chemistry

  0•0•1•0•Updated Jul 12, 2024Jul 12, 2024

• CNP20-CHIKVhelicase-VirtualScreen

  Public
  An SGC Open Chemistry Networks Project (number 20) dedicated to finding hits vs CHIKV nsp2 helicase based on a Virtual Screen of Enamine REAL compounds.

  drug-discoveryvirtual-screeningmedicinal-chemistry

  0•0•0•0•Updated Jul 12, 2024Jul 12, 2024

• CNP10-CHIKV-Naphthoquinone

  Public
  An Open Chemistry Network dedicated to finding hits vs CHIKV based on a hit containing an naphthoquinone.

  drug-discoverymedicinal-chemistry

  0•0•1•0•Updated Jul 12, 2024Jul 12, 2024

• CNP16-iminoquinone-SarsRdRp-mechanstic-study

  Public
  0•0•7•0•Updated Jul 10, 2024Jul 10, 2024

• CNP24-NSP10_14-Frags

  Public
  This project aims to develop potent inhibitors of NSP14/NSP10 for the treatment of (CoV-19), Targeting the NSP14 and NSP10 interacting interface with small molecules or peptides could be a smart strategy to obstruct replication processes of coronaviruses (CoVs).

  0•1•2•0•Updated Jul 1, 2024Jul 1, 2024

• CNP9-DENVRdrp-ChEMBL

  Public
  An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the ChEMBL database. Please use the link below to view all projects in the READDI-AViDD pipeline.

  data-miningdrug-discoverychembl+ 2medicinal-chemistryphenotypic-data

  0•0•0•0•Updated May 31, 2024May 31, 2024

• CNP8-Nsp13-Indoles

  Public
  An Open Chemistry Network dedicated to finding hits vs SARS-CoV-2 Nsp13 based on a hit containing an indole.

  0•0•2•0•Updated May 13, 2024May 13, 2024

• CNP35-CHIKV-nsp2-helicase-spiro

  Public
  0•0•0•0•Updated May 6, 2024May 6, 2024

• CNP36-EBOV-RdRp-inhibitors

  Public
  0•0•0•0•Updated May 6, 2024May 6, 2024

• Pipeline

  Public
  https://docs.google.com/spreadsheets/d/1TanvenS56FovmyT8BoxloH2iHP4jjVcusho2F5nwDeU/edit?usp=sharing

  The Unlicense

  •0•1•0•0•Updated May 3, 2024May 3, 2024

• CNP7-RdRp-S1-Tetrazole

  Public
  An Open Chemistry Networks Project Targeting SARS-CoV-2 RdRp

  0•0•2•0•Updated May 1, 2024May 1, 2024

• CNP37-CHIKV-Protease-HTS-non-covalent

  Public
  0•0•0•0•Updated May 1, 2024May 1, 2024

• CNP39-SARS2-RdRp-HTS-TAMU

  Public
  0•0•0•0•Updated May 1, 2024May 1, 2024

• CNP40-SARS2-RdRp-HTS-UNC

  Public
  0•0•0•0•Updated May 1, 2024May 1, 2024

• CNP23-SARS-CoV2-RdRp

  Public
  0•0•1•0•Updated Apr 22, 2024Apr 22, 2024

• CNP22-CHIKV-Nsp2-Protease

  Public
  This project aims to develop new CHICKV NSP2 protease inhibitors with high potency and selectivity as well as with an improved physicochemical properties.

  0•0•0•0•Updated Apr 22, 2024Apr 22, 2024

• CNP38_VEEV-nsP2-Protease_Covalent

  Public
  0•0•0•0•Updated Mar 26, 2024Mar 26, 2024

• CNP29_CHIKVnsp2_DEL-ML

  Public
  An SGC Open Chemistry Networks Project (number 29) dedicated to finding hits vs CHIKV nsp2 helicase based on a DEL screen and subsequent machine learning by X-Chem.

  0•0•2•0•Updated Mar 18, 2024Mar 18, 2024

• CNP33_SARS-CoV-2_nsP12-RdRp_HTS

  Public
  SARS-CoV-2 nsP12 RdRp inhibitor development campaign by HTS

  0•0•0•0•Updated Mar 18, 2024Mar 18, 2024