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| 1 | +#! /usr/bin/env |
| 2 | + |
| 3 | + |
| 4 | +from dendropy import Tree, TaxonNamespace |
| 5 | +from sys import argv |
| 6 | +import argparse |
| 7 | +from scipy.stats import poisson |
| 8 | +from math import log |
| 9 | + |
| 10 | +parser = argparse.ArgumentParser() |
| 11 | + |
| 12 | +parser.add_argument("-b","--bTree", required=True,help="Input tree with branch length in substitution unit") |
| 13 | +parser.add_argument("-c","--cTree", required=True,help="Calibrated tree. Must have the same rooted topology as bTree") |
| 14 | +parser.add_argument("-r","--rate", required=False,help="Global mutation rate. Default: 1.0") |
| 15 | +parser.add_argument("-l","--length", required=False,help="Sequence length. Default: 1000") |
| 16 | +parser.add_argument("-o","--output", required=True,help="Output file") |
| 17 | + |
| 18 | +args = vars(parser.parse_args()) |
| 19 | + |
| 20 | +taxa = TaxonNamespace() |
| 21 | + |
| 22 | +b_tree = Tree.get_from_path(args["bTree"],schema="newick",taxon_namespace=taxa) |
| 23 | +c_tree = Tree.get_from_path(args["cTree"],schema="newick",taxon_namespace=taxa) |
| 24 | +r = float(args["rate"]) if args["rate"] else 1.0 |
| 25 | +l = float(args["length"]) if args["length"] else 1000 |
| 26 | + |
| 27 | +b_tree.is_rooted = True |
| 28 | +c_tree.is_rooted = True |
| 29 | + |
| 30 | +b_tree.encode_bipartitions() |
| 31 | +c_tree.encode_bipartitions() |
| 32 | + |
| 33 | +mapping = {} |
| 34 | +llh = 0 |
| 35 | + |
| 36 | +for node in b_tree.postorder_node_iter(): |
| 37 | + if node is not b_tree.seed_node: |
| 38 | + mapping[node.bipartition] = node.edge_length |
| 39 | + |
| 40 | + |
| 41 | +for node in c_tree.postorder_node_iter(): |
| 42 | + if node is not c_tree.seed_node: |
| 43 | + b = int(mapping[node.bipartition]*l) |
| 44 | + ld = int(node.edge_length*r*l) |
| 45 | + llh += log(poisson.pmf(b,ld)) |
| 46 | + |
| 47 | +with open(args["output"],'w') as fout: |
| 48 | + fout.write(str(llh) + "\n") |
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